SIMILAR PATTERNS OF AMINO ACIDS FOR 3BJW_A_SVRA508_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4i METHYLENETETRAHYDROF
OLATE DEHYDROGENASE
/
METHENYLTETRAHYDROFO
LATE CYCLOHYDROLASE

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 VAL A 271
GLY A 273
PRO A 277
THR A 279
GLY A 151
 None
None
None
NDP  A 302 ( 3.7A)
None
 1.08A 3bjwG-1a4iA:
0.0		 3bjwG-1a4iA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 VAL A 331
GLY A 327
LYS A 326
THR A 153
GLY A 156
 None
None
None
LLP  A 198 ( 3.5A)
None
 1.11A 3bjwG-1bjnA:
0.0		 3bjwG-1bjnA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF00266
(Aminotran_5) 		5 VAL A 331
GLY A 327
LYS A 326
THR A 153
GLY A 156
 None
None
None
PLP  A 363 (-3.3A)
None
 1.24A 3bjwG-1bt4A:
0.0		 3bjwG-1bt4A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 290
VAL A 291
GLY A 316
THR A 178
GLY A 181
 None
None
None
NAD  A1377 (-2.8A)
None
 1.40A 3bjwG-1d1tA:
0.0		 3bjwG-1d1tA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 VAL A  56
VAL A  77
GLY A  78
GLY A  48
LYS A  45
 None
None
None
A79  A 800 (-4.1A)
None
 1.40A 3bjwG-1hvcA:
undetectable		 3bjwG-1hvcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 VAL A  57
GLY A 135
PRO A 150
THR A 151
GLY A  50
 None
 1.13A 3bjwG-1kplA:
0.0		 3bjwG-1kplA:
10.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		5 GLY A1006
LYS A1007
PRO A1017
LYS A1069
ARG A1072
 IPA  A1136 (-3.6A)
None
IPA  A1136 (-4.4A)
None
None
 1.29A 3bjwG-1mc2A:
20.0		 3bjwG-1mc2A:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		5 GLY A 331
PRO A 315
THR A 336
GLY A 337
ARG A 290
 None
 1.33A 3bjwG-1ohfA:
0.0		 3bjwG-1ohfA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		5 VAL A 349
GLY A 365
THR A 328
GLY A 345
ARG A 233
 None
 1.46A 3bjwG-1q3sA:
2.3		 3bjwG-1q3sA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv9 HYDROLASE, HALOACID
DEHALOGENASE FAMILY

(Enterococcus
faecalis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 VAL A 120
VAL A 119
GLY A 146
PRO A 178
THR A 176
 None
 1.48A 3bjwG-1yv9A:
undetectable		 3bjwG-1yv9A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4g DIHYDROOROTATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF01180
(DHO_dh) 		5 VAL A 134
GLY A  71
THR A  47
GLY A 101
LYS A 137
 None
ORO  A1399 (-3.7A)
None
None
None
 1.44A 3bjwG-2b4gA:
undetectable		 3bjwG-2b4gA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5p GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Kluyveromyces
marxianus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL O 130
GLY O 131
PRO O 156
THR O 290
GLY O 272
 None
 1.36A 3bjwG-2i5pO:
0.5		 3bjwG-2i5pO:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		5 VAL A 278
VAL A 279
GLY A 294
PRO A 316
GLY A 275
 None
 1.27A 3bjwG-2iuyA:
undetectable		 3bjwG-2iuyA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbp LEUCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		5 VAL A   7
VAL A   8
GLY A  75
PRO A  99
GLY A  25
 None
 1.40A 3bjwG-2lbpA:
undetectable		 3bjwG-2lbpA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsg HYPOTHETICAL PROTEIN
CGL3021

(Corynebacterium
glutamicum) 		PF11716
(MDMPI_N) 		5 VAL A 207
VAL A 187
PRO A 235
GLY A 232
ARG A 196
 None
 1.26A 3bjwG-2nsgA:
1.5		 3bjwG-2nsgA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 VAL A  96
VAL A  95
GLY A  94
THR A 356
GLY A 376
 None
 1.49A 3bjwG-2o4cA:
undetectable		 3bjwG-2o4cA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN

(Archaeoglobus
fulgidus) 		PF10609
(ParA) 		5 VAL A 184
VAL A 157
GLY A 155
PRO A 153
THR A 180
 None
 1.25A 3bjwG-2ph1A:
undetectable		 3bjwG-2ph1A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgq PROTEIN TM_1862

(Thermotoga
maritima) 		PF04055
(Radical_SAM) 		5 VAL A 415
VAL A 416
GLY A 427
LYS A 418
GLY A 388
 None
 1.42A 3bjwG-2qgqA:
undetectable		 3bjwG-2qgqA:
15.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qhe PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		6 VAL A   2
VAL A   3
GLY A   6
PRO A  18
THR A  23
GLY A  30
 None
 0.76A 3bjwG-2qheA:
22.6		 3bjwG-2qheA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		5 VAL A  57
GLY A 135
PRO A 150
THR A 151
LYS A  55
 None
 1.40A 3bjwG-2r9hA:
undetectable		 3bjwG-2r9hA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxb COENZYME
B12-DEPENDENT MUTASE

(Aeropyrum
pernix) 		PF02310
(B12-binding) 		5 VAL A  40
VAL A  39
GLY A  36
GLY A  76
ARG A  42
 None
 1.28A 3bjwG-2yxbA:
undetectable		 3bjwG-2yxbA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 134
VAL A 163
PRO A  46
THR A  44
GLY A  43
 None
None
CA  A 401 ( 4.7A)
None
None
 1.40A 3bjwG-3gazA:
undetectable		 3bjwG-3gazA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN

(Desulfovibrio
vulgaris) 		PF13690
(CheX) 		5 VAL A  94
VAL A  91
GLY A  92
PRO A 118
GLY A 100
 None
 1.22A 3bjwG-3h4yA:
undetectable		 3bjwG-3h4yA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm4 CHEMOTAXIS PROTEIN
CHEX

(Desulfovibrio
alaskensis) 		PF13690
(CheX) 		5 VAL A  94
VAL A  91
GLY A  92
PRO A 118
GLY A 100
 None
 1.13A 3bjwG-3hm4A:
undetectable		 3bjwG-3hm4A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 VAL A 336
GLY A 101
LYS A 102
PRO A 326
GLY A 372
 None
 1.42A 3bjwG-3iwjA:
undetectable		 3bjwG-3iwjA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp5 PUTATIVE CELL
SURFACE HYDROLASE

(Lactobacillus
plantarum) 		PF06028
(DUF915) 		5 VAL A 187
GLY A 190
LYS A 191
THR A 132
GLY A 108
 None
 1.41A 3bjwG-3lp5A:
0.2		 3bjwG-3lp5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph2 CYTOCHROME C6

(Phormidium
laminosum) 		PF13442
(Cytochrome_CBB3) 		5 VAL B  52
VAL B  51
GLY B  55
LYS B  56
GLY B  64
 IMD  B1088 (-4.5A)
IMD  B1088 (-4.3A)
IMD  B1088 ( 4.4A)
HEM  B1087 (-2.8A)
None
 1.18A 3bjwG-3ph2B:
undetectable		 3bjwG-3ph2B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		5 VAL A 331
GLY A 327
LYS A 326
THR A 153
GLY A 156
 None
 1.12A 3bjwG-3qm2A:
undetectable		 3bjwG-3qm2A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 VAL A 580
GLY A 584
PRO A 603
THR A 604
GLY A 519
 None
 1.29A 3bjwG-3r75A:
undetectable		 3bjwG-3r75A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 5 VAL A  87
VAL A 226
GLY A 224
PRO A 498
GLY A 140
 None
 1.45A 3bjwG-3wevA:
undetectable		 3bjwG-3wevA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 VAL A 257
GLY A 259
PRO A 263
THR A 265
GLY A 144
 EDO  A1286 ( 4.9A)
EDO  A1286 (-3.7A)
EDO  A1286 (-4.3A)
None
None
 1.20A 3bjwG-4b4uA:
1.9		 3bjwG-4b4uA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		5 VAL A1804
VAL A1805
GLY A1808
PRO B  59
THR B  63
 None
 0.93A 3bjwG-4by6A:
undetectable		 3bjwG-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 VAL J 358
VAL J 361
GLY J 360
PRO K 331
GLY J 192
 None
 1.35A 3bjwG-4cr4J:
undetectable		 3bjwG-4cr4J:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG
26S PROTEASE
REGULATORY SUBUNIT 8
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 VAL J 358
VAL J 361
GLY J 360
PRO K 331
GLY J 194
 None
 1.27A 3bjwG-4cr4J:
undetectable		 3bjwG-4cr4J:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxh ELONGATION FACTOR 1A

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 VAL A 169
VAL A 170
LYS A 174
THR A 132
GLY A 125
 None
 0.86A 3bjwG-4cxhA:
undetectable		 3bjwG-4cxhA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d01 NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-9

(Homo sapiens) 		PF02931
(Neur_chan_LBD) 		5 VAL A  30
VAL A 158
GLY A 155
PRO A 198
LYS A  29
 None
 1.49A 3bjwG-4d01A:
undetectable		 3bjwG-4d01A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 VAL A 338
GLY A 103
LYS A 104
PRO A 328
GLY A 374
 None
 1.49A 3bjwG-4i8pA:
undetectable		 3bjwG-4i8pA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		5 VAL A  30
VAL A  31
GLY A   6
THR A  10
GLY A  14
 None
 1.10A 3bjwG-4mioA:
undetectable		 3bjwG-4mioA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwv HIGH-AFFINITY
LEUCINE-SPECIFIC
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN, CHEMOTAXIS
PROTEIN CHEY

(Escherichia
coli;
Thermotoga
maritima) 		PF00072
(Response_reg)
PF13458
(Peripla_BP_6) 		5 VAL A   7
VAL A   8
GLY A  75
PRO A  99
GLY A  25
 None
 1.43A 3bjwG-4qwvA:
undetectable		 3bjwG-4qwvA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		5 VAL A  35
GLY A 108
PRO A  85
THR A  87
GLY A  88
 None
 1.15A 3bjwG-4yeuA:
1.2		 3bjwG-4yeuA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF00955
(HCO3_cotransp) 		5 VAL A 709
VAL A 710
GLY A 713
THR A 444
GLY A 448
 None
 0.95A 3bjwG-4yzfA:
undetectable		 3bjwG-4yzfA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5z GLUTAMYL-TRNA
AMIDOTRANSFERASE

(Escherichia
coli) 		no annotation 5 VAL A  63
VAL A   8
GLY A  10
PRO A  49
GLY A 117
 None
 1.00A 3bjwG-5c5zA:
undetectable		 3bjwG-5c5zA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8v AMINOTRANSFERASE,
CLASS V FAMILY
PROTEIN

(Trichomonas
vaginalis) 		PF00266
(Aminotran_5) 		5 VAL A 342
GLY A 338
LYS A 337
THR A 158
GLY A 161
 None
None
None
LLP  A 202 ( 3.0A)
None
 1.13A 3bjwG-5f8vA:
undetectable		 3bjwG-5f8vA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 VAL A 265
GLY A 263
PRO A 257
THR A 255
GLY A 253
 None
 1.26A 3bjwG-5hp5A:
undetectable		 3bjwG-5hp5A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 VAL A 308
GLY A 310
PRO A 314
THR A 316
GLY A 179
 None
L34  A 402 (-3.6A)
L34  A 402 (-4.5A)
NAD  A 401 (-3.2A)
None
 1.21A 3bjwG-5tc4A:
undetectable		 3bjwG-5tc4A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		5 VAL A 262
GLY A 265
PRO A 268
THR A 270
GLY A 148
 None
None
None
GOL  A 305 (-4.7A)
None
 1.40A 3bjwG-6apeA:
undetectable		 3bjwG-6apeA:
17.35