SIMILAR PATTERNS OF AMINO ACIDS FOR 3BGR_A_T27A556_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ASN A 416
VAL A 153
PHE A 413
TYR A 612
GLU A 331
 None
 1.44A 3bgrA-1dmsA:
0.0
3bgrB-1dmsA:
0.4		 3bgrA-1dmsA:
21.80
3bgrB-1dmsA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 LEU A  98
VAL A  47
TYR A  67
TRP A  78
LEU A  69
 None
 1.28A 3bgrA-1h39A:
undetectable
3bgrB-1h39A:
0.0		 3bgrA-1h39A:
21.29
3bgrB-1h39A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9) 		5 LEU A 165
ASN A  74
CYH A  78
TYR A  80
LEU A 171
 None
 1.07A 3bgrA-1m4iA:
0.1
3bgrB-1m4iA:
0.0		 3bgrA-1m4iA:
13.82
3bgrB-1m4iA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU E 235
VAL E 203
TYR E 195
LEU E 232
GLU E 200
 None
 1.36A 3bgrA-1nfiE:
0.0
3bgrB-1nfiE:
undetectable		 3bgrA-1nfiE:
17.30
3bgrB-1nfiE:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox8 STRINGENT STARVATION
PROTEIN B

(Escherichia
coli) 		PF04386
(SspB) 		5 LEU A  65
VAL A  90
PHE A  72
LEU A  63
TYR A  18
 None
 1.49A 3bgrA-1ox8A:
undetectable
3bgrB-1ox8A:
undetectable		 3bgrA-1ox8A:
12.90
3bgrB-1ox8A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhv DIPHTHINE SYNTHASE

(Archaeoglobus
fulgidus) 		PF00590
(TP_methylase) 		5 LEU A 123
CYH A 203
TYR A 187
PHE A 233
LEU A 228
 None
 1.26A 3bgrA-1vhvA:
0.0
3bgrB-1vhvA:
0.0		 3bgrA-1vhvA:
17.83
3bgrB-1vhvA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 LEU A 119
VAL A 362
TYR A 368
LEU A 369
TYR A 123
 None
 1.43A 3bgrA-1w6jA:
0.0
3bgrB-1w6jA:
0.0		 3bgrA-1w6jA:
21.18
3bgrB-1w6jA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		5 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A 900 (-3.8A)
None
None
 1.12A 3bgrA-1z6tA:
1.1
3bgrB-1z6tA:
0.8		 3bgrA-1z6tA:
23.05
3bgrB-1z6tA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgj ISOFLAVANONE
4'-O-METHYLTRANSFERA
SE'

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 LEU A 279
VAL A 295
TYR A 348
TRP A 336
LEU A 339
 None
 1.48A 3bgrA-1zgjA:
1.6
3bgrB-1zgjA:
0.4		 3bgrA-1zgjA:
19.55
3bgrB-1zgjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 LEU A 243
TYR A 294
PHE A 272
LEU A 277
GLU A 285
 None
 1.10A 3bgrA-2bmaA:
undetectable
3bgrB-2bmaA:
undetectable		 3bgrA-2bmaA:
21.27
3bgrB-2bmaA:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
TYR A 188
PHE A 227
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 (-4.7A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 1.06A 3bgrA-2hnzA:
35.2
3bgrB-2hnzA:
14.1		 3bgrA-2hnzA:
98.13
3bgrB-2hnzA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
VAL A 179
TYR A 188
PHE A 227
TYR A 318
 PC0  A 999 ( 3.9A)
PC0  A 999 (-4.4A)
PC0  A 999 (-4.1A)
PC0  A 999 (-4.7A)
PC0  A 999 (-4.3A)
 1.08A 3bgrA-2hnzA:
35.2
3bgrB-2hnzA:
14.1		 3bgrA-2hnzA:
98.13
3bgrB-2hnzA:
98.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 LEU A 766
VAL A 549
TYR A 601
TYR A 545
GLU A 607
 None
 1.45A 3bgrA-2jgdA:
0.3
3bgrB-2jgdA:
undetectable		 3bgrA-2jgdA:
20.04
3bgrB-2jgdA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lm4 SUCCINATE
DEHYDROGENASE
ASSEMBLY FACTOR 2,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF03937
(Sdh5) 		5 LEU A  64
TYR A  73
LEU A  42
TYR A  61
GLU A  67
 None
 1.28A 3bgrA-2lm4A:
undetectable
3bgrB-2lm4A:
undetectable		 3bgrA-2lm4A:
12.32
3bgrB-2lm4A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF00620
(RhoGAP) 		5 LEU A 310
VAL A 265
TYR A 257
LEU A 253
TYR A 249
 LEU  A 310 ( 0.6A)
VAL  A 265 ( 0.6A)
TYR  A 257 ( 1.3A)
LEU  A 253 ( 0.6A)
TYR  A 249 ( 1.3A)
 1.49A 3bgrA-2qv2A:
undetectable
3bgrB-2qv2A:
undetectable		 3bgrA-2qv2A:
20.63
3bgrB-2qv2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv4 HYPOTHETICAL PROTEIN
PH0435

(Pyrococcus
horikoshii) 		PF03481
(SUA5) 		5 LEU A 285
VAL A 271
TYR A 335
LEU A 296
GLU A 314
 None
 1.15A 3bgrA-2yv4A:
undetectable
3bgrB-2yv4A:
undetectable		 3bgrA-2yv4A:
10.25
3bgrB-2yv4A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h35 UNCHARACTERIZED
PROTEIN ABO_0056

(Alcanivorax
borkumensis) 		no annotation 5 VAL A  85
TYR A  89
TYR A  87
LEU A 108
GLU A 158
 None
 1.24A 3bgrA-3h35A:
undetectable
3bgrB-3h35A:
undetectable		 3bgrA-3h35A:
15.82
3bgrB-3h35A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
EPSILON

(Saccharomyces
cerevisiae) 		PF04733
(Coatomer_E) 		5 ASN B 235
VAL B  16
CYH B  18
TYR B  36
TYR B 239
 None
 1.48A 3bgrA-3mv3B:
undetectable
3bgrB-3mv3B:
undetectable		 3bgrA-3mv3B:
21.42
3bgrB-3mv3B:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9x ASCH DOMAIN

(Vibrio cholerae) 		PF04266
(ASCH) 		5 LEU A  74
TYR A 153
PHE A   8
LEU A   9
GLU A  89
 None
 1.34A 3bgrA-3s9xA:
undetectable
3bgrB-3s9xA:
undetectable		 3bgrA-3s9xA:
13.39
3bgrB-3s9xA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		5 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A1250 (-3.4A)
None
None
 1.04A 3bgrA-3sfzA:
1.3
3bgrB-3sfzA:
undetectable		 3bgrA-3sfzA:
17.91
3bgrB-3sfzA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX

(Homo sapiens) 		PF03097
(BRO1) 		5 LEU A 274
TYR A 252
TYR A 281
PHE A 309
LEU A 312
 None
 1.41A 3bgrA-3um1A:
0.8
3bgrB-3um1A:
0.7		 3bgrA-3um1A:
21.31
3bgrB-3um1A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX

(Homo sapiens) 		PF03097
(BRO1) 		5 TYR A 252
TYR A 281
PHE A 309
LEU A 312
GLU A 276
 None
None
None
None
GOL  A   1 (-3.3A)
 1.36A 3bgrA-3um1A:
0.8
3bgrB-3um1A:
0.7		 3bgrA-3um1A:
21.31
3bgrB-3um1A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis) 		PF16754
(Pesticin) 		5 ASN A 149
VAL A 147
PHE A 159
LEU A 156
GLU A  97
 None
 1.32A 3bgrA-4arpA:
undetectable
3bgrB-4arpA:
undetectable		 3bgrA-4arpA:
23.20
3bgrB-4arpA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx HISTONE DEACETYLASE
1

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 LEU B  41
ASN B  44
PHE B 334
LEU B 328
TYR B  45
 None
 1.46A 3bgrA-4bkxB:
0.5
3bgrB-4bkxB:
undetectable		 3bgrA-4bkxB:
20.64
3bgrB-4bkxB:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		5 LEU A 660
VAL A 370
TYR A 603
LEU A 721
GLU A 597
 None
 1.44A 3bgrA-4c1oA:
undetectable
3bgrB-4c1oA:
0.6		 3bgrA-4c1oA:
21.61
3bgrB-4c1oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df3 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Aeropyrum
pernix) 		PF01269
(Fibrillarin) 		5 LEU A  66
VAL A 215
TYR A 177
TYR A 228
LEU A  73
 None
 1.36A 3bgrA-4df3A:
undetectable
3bgrB-4df3A:
undetectable		 3bgrA-4df3A:
16.10
3bgrB-4df3A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		5 LEU A 447
PHE A 422
LEU A 425
TYR A 443
GLU A 450
 None
 1.43A 3bgrA-4eppA:
0.1
3bgrB-4eppA:
undetectable		 3bgrA-4eppA:
22.86
3bgrB-4eppA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gft MYOSIN A TAIL DOMAIN
INTERACTING PROTEIN
NANOBODY

(Lama glama;
Plasmodium
falciparum) 		PF07686
(V-set)
PF13405
(EF-hand_6) 		5 LEU A 203
VAL B 105
TYR B 115
TYR B  34
LEU A 175
 None
None
PCA  B   2 ( 3.9A)
None
None
 1.08A 3bgrA-4gftA:
undetectable
3bgrB-4gftA:
undetectable		 3bgrA-4gftA:
7.99
3bgrB-4gftA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf8 NUP188

(Thermothelomyces
thermophila) 		no annotation 5 LEU A1455
VAL A1558
CYH A1555
PHE A1485
LEU A1484
 None
 1.41A 3bgrA-4kf8A:
undetectable
3bgrB-4kf8A:
undetectable		 3bgrA-4kf8A:
20.77
3bgrB-4kf8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okh CALPAIN-3

(Homo sapiens) 		PF00036
(EF-hand_1)
PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		5 LEU A 758
ASN A 752
TYR A 770
PHE A 786
LEU A 789
 None
 1.05A 3bgrA-4okhA:
undetectable
3bgrB-4okhA:
0.9		 3bgrA-4okhA:
14.31
3bgrB-4okhA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ose PUTATIVE HYDROLASE

(Rickettsia
typhi) 		PF00561
(Abhydrolase_1) 		5 LEU A  59
TYR A 281
LEU A 286
TYR A  63
GLU A  58
 None
 1.40A 3bgrA-4oseA:
undetectable
3bgrB-4oseA:
undetectable		 3bgrA-4oseA:
20.29
3bgrB-4oseA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00571
(CBS) 		5 LEU G 249
ASN G 257
VAL G 260
TYR G 214
LEU G  95
 None
 1.21A 3bgrA-4rerG:
undetectable
3bgrB-4rerG:
undetectable		 3bgrA-4rerG:
19.26
3bgrB-4rerG:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		5 LEU A 638
VAL A 348
TYR A 581
LEU A 699
GLU A 575
 None
 1.47A 3bgrA-4rhhA:
undetectable
3bgrB-4rhhA:
0.7		 3bgrA-4rhhA:
22.25
3bgrB-4rhhA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 5 LEU C 587
TYR C 595
PHE C 566
LEU C 495
GLU C 470
 None
 1.48A 3bgrA-4wzsC:
0.7
3bgrB-4wzsC:
undetectable		 3bgrA-4wzsC:
21.35
3bgrB-4wzsC:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		5 LEU A 138
VAL A  57
TYR A  53
LEU A 136
GLU A  68
 None
 1.31A 3bgrA-4wzzA:
2.1
3bgrB-4wzzA:
undetectable		 3bgrA-4wzzA:
21.07
3bgrB-4wzzA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwu NUCLEOPORIN NUP188

(Chaetomium
thermophilum) 		no annotation 5 LEU A1457
VAL A1561
CYH A1558
PHE A1487
LEU A1486
 None
 1.40A 3bgrA-5cwuA:
undetectable
3bgrB-5cwuA:
undetectable		 3bgrA-5cwuA:
20.57
3bgrB-5cwuA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejs MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF09380
(FERM_C) 		5 LEU A2269
ASN A2291
PHE A2275
TRP A2287
LEU A2274
 None
 1.31A 3bgrA-5ejsA:
undetectable
3bgrB-5ejsA:
1.1		 3bgrA-5ejsA:
21.96
3bgrB-5ejsA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Bacillus cereus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 LEU A  81
VAL A  89
CYH A  58
PHE A  62
TYR A  75
 None
 0.90A 3bgrA-5je8A:
undetectable
3bgrB-5je8A:
undetectable		 3bgrA-5je8A:
22.30
3bgrB-5je8A:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 LEU B 278
ASN B 280
TRP B 294
LEU B 256
GLU B 301
 None
 1.45A 3bgrA-5ovnB:
10.3
3bgrB-5ovnB:
11.1		 3bgrA-5ovnB:
59.52
3bgrB-5ovnB:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugz PUTATIVE
THIOESTERASE

(Escherichia
coli) 		PF00975
(Thioesterase) 		5 LEU A 134
VAL A 117
TYR A 162
LEU A 188
GLU A 130
 None
 1.44A 3bgrA-5ugzA:
undetectable
3bgrB-5ugzA:
undetectable		 3bgrA-5ugzA:
18.09
3bgrB-5ugzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		5 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
 1.19A 3bgrA-5wveA:
undetectable
3bgrB-5wveA:
undetectable		 3bgrA-5wveA:
19.67
3bgrB-5wveA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4m YERSINOPINE
DEHYDROGENASE

(Yersinia pestis) 		no annotation 5 LEU C  33
ASN C  35
TYR C  55
TYR C 184
LEU C  48
 None
NAP  C 501 (-3.0A)
None
None
None
 1.36A 3bgrA-6c4mC:
undetectable
3bgrB-6c4mC:
undetectable		 3bgrA-6c4mC:
9.63
3bgrB-6c4mC:
9.88