SIMILAR PATTERNS OF AMINO ACIDS FOR 3BGD_B_PM6B302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4v TNF-RELATED
APOPTOSIS INDUCING
LIGAND

(Homo sapiens) 		PF00229
(TNF) 		4 PHE B 275
LEU B 174
LEU B 164
LEU B 169
 None
 0.78A 3bgdB-1d4vB:
undetectable		 3bgdB-1d4vB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dg6 APO2L/TNF-RELATED
APOPOTIS INDUCING
LIGAND (TRAIL)

(Homo sapiens) 		PF00229
(TNF) 		4 PHE A 275
LEU A 174
LEU A 164
LEU A 169
 None
 0.64A 3bgdB-1dg6A:
undetectable		 3bgdB-1dg6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gan GALECTIN-1

(Rhinella
arenarum) 		PF00337
(Gal-bind_lectin) 		4 PHE A  90
LEU A  35
LEU A  10
LEU A 121
 None
 0.94A 3bgdB-1ganA:
undetectable		 3bgdB-1ganA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 PHE A   4
LEU A  91
LEU A  66
LEU A  86
 None
 0.93A 3bgdB-1jjxA:
undetectable		 3bgdB-1jjxA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxi PHOSPHOMETHYLPYRIMID
INE KINASE

(Salmonella
enterica) 		PF08543
(Phos_pyr_kin) 		4 THR A 232
LEU A 189
LEU A 135
LEU A 174
 None
 0.83A 3bgdB-1jxiA:
0.8		 3bgdB-1jxiA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 HIS A 237
PHE A 241
LEU A 445
LEU A 407
 MGD  A1019 ( 4.5A)
None
None
None
 0.79A 3bgdB-1kqfA:
2.6		 3bgdB-1kqfA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqg FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF09163
(Form-deh_trans)
PF12800
(Fer4_4)
PF13247
(Fer4_11) 		4 HIS B 229
GLN B 233
LEU B  94
LEU B 236
 None
 0.87A 3bgdB-1kqgB:
undetectable		 3bgdB-1kqgB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 THR A 125
LEU A 135
LEU A 112
LEU A 110
 None
 0.80A 3bgdB-1oznA:
0.0		 3bgdB-1oznA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 THR A 173
LEU A 183
LEU A 161
LEU A 159
 None
 0.90A 3bgdB-1oznA:
0.0		 3bgdB-1oznA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 THR A 173
LEU A 185
LEU A 166
LEU A 161
 None
 0.89A 3bgdB-1oznA:
0.0		 3bgdB-1oznA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc6 PROTEIN NINB

(Escherichia
virus Lambda) 		PF05772
(NinB) 		4 THR A  77
PHE A  76
LEU A  49
LEU A  53
 BME  A 300 (-3.4A)
None
None
None
 0.85A 3bgdB-1pc6A:
undetectable		 3bgdB-1pc6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pca PROCARBOXYPEPTIDASE
A PCPA

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 PHE A  67
LEU A  29
LEU A  34
LEU A  32
 None
 0.65A 3bgdB-1pcaA:
undetectable		 3bgdB-1pcaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		4 PHE A   4
LEU A  91
LEU A  66
LEU A  86
 None
 0.66A 3bgdB-1pmpA:
undetectable		 3bgdB-1pmpA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt PROCARBOXYPEPTIDASE
A

(Bos taurus) 		PF02244
(Propep_M14) 		4 PHE A  67
LEU A  29
LEU A  34
LEU A  32
 None
 0.76A 3bgdB-1pytA:
undetectable		 3bgdB-1pytA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thx THIOREDOXIN

(Nostoc sp. PCC
7120) 		PF00085
(Thioredoxin) 		4 PHE A 102
LEU A  80
LEU A  53
LEU A  24
 None
 0.68A 3bgdB-1thxA:
undetectable		 3bgdB-1thxA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 PHE A   4
LEU A  91
LEU A  66
LEU A  86
 None
 0.65A 3bgdB-1towA:
undetectable		 3bgdB-1towA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut1 DR HEMAGGLUTININ
STRUCTURAL SUBUNIT

(Escherichia
coli) 		PF04619
(Adhesin_Dr) 		4 THR A  16
GLN A  34
LEU A  35
LEU A  13
 EDO  A1141 (-4.4A)
EDO  A1143 (-4.7A)
None
None
 0.92A 3bgdB-1ut1A:
undetectable		 3bgdB-1ut1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wk2 HYPOTHETICAL PROTEIN

(Thermus
thermophilus) 		PF04266
(ASCH) 		4 HIS A  34
THR A  32
LEU A  38
LEU A   8
 None
 0.85A 3bgdB-1wk2A:
undetectable		 3bgdB-1wk2A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wox HEME OXYGENASE 2

(Synechocystis
sp. PCC 6803) 		PF01126
(Heme_oxygenase) 		4 HIS A 122
THR A 125
LEU A  52
LEU A  48
 None
HEM  A 300 (-4.7A)
None
None
 0.86A 3bgdB-1woxA:
undetectable		 3bgdB-1woxA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Chromobacterium
violaceum) 		PF04952
(AstE_AspA) 		4 HIS A 172
LEU A 330
LEU A 190
LEU A 257
 None
 0.88A 3bgdB-1yw4A:
undetectable		 3bgdB-1yw4A:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bzg THIOPURINE
S-METHYLTRANSFERASE

(Homo sapiens) 		PF05724
(TPMT) 		5 HIS A  52
THR A  55
GLN A 179
LEU A 217
LEU A 241
 None
 0.55A 3bgdB-2bzgA:
39.3		 3bgdB-2bzgA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bzg THIOPURINE
S-METHYLTRANSFERASE

(Homo sapiens) 		PF05724
(TPMT) 		4 THR A  55
GLN A 179
LEU A 181
LEU A 241
 None
 0.88A 3bgdB-2bzgA:
39.3		 3bgdB-2bzgA:
71.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 THR A 120
LEU A 200
LEU A 163
LEU A 140
 None
 0.91A 3bgdB-2d52A:
undetectable		 3bgdB-2d52A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00456
(Transketolase_N) 		4 THR A 587
GLN A 222
LEU A 211
LEU A 208
 None
 0.87A 3bgdB-2g28A:
0.8		 3bgdB-2g28A:
15.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gb4 THIOPURINE
S-METHYLTRANSFERASE

(Mus musculus) 		PF05724
(TPMT) 		7 HIS A  47
THR A  50
PHE A  51
GLN A 174
LEU A 176
LEU A 212
LEU A 236
 None
 0.31A 3bgdB-2gb4A:
42.0		 3bgdB-2gb4A:
95.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knh PROTEIN CBFA2T1

(Homo sapiens) 		PF07531
(TAFH) 		4 GLN A 341
LEU A 340
LEU A 333
LEU A 337
 None
 0.88A 3bgdB-2knhA:
undetectable		 3bgdB-2knhA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8v THIOREDOXIN 1

(Escherichia
coli) 		PF00085
(Thioredoxin) 		4 PHE B 102
LEU B  80
LEU B  53
LEU B  24
 None
 0.82A 3bgdB-2o8vB:
undetectable		 3bgdB-2o8vB:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 HIS A 299
GLN A 278
LEU A 294
LEU A 292
 None
 0.86A 3bgdB-2okxA:
undetectable		 3bgdB-2okxA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppq HOMOSERINE KINASE

(Agrobacterium
fabrum) 		PF01636
(APH) 		4 THR A  51
LEU A  91
LEU A  66
LEU A  62
 None
 0.86A 3bgdB-2ppqA:
undetectable		 3bgdB-2ppqA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3x REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00168
(C2) 		4 PHE A1533
LEU A1504
LEU A1566
LEU A1542
 None
 0.88A 3bgdB-2q3xA:
undetectable		 3bgdB-2q3xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 PHE A   4
LEU A  91
LEU A  66
LEU A  86
 None
 0.70A 3bgdB-2q9sA:
undetectable		 3bgdB-2q9sA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzq AXIN INTERACTOR,
DORSALIZATION
ASSOCIATED PROTEIN

(Danio rerio) 		PF14186
(Aida_C2) 		4 GLN A 166
LEU A 168
LEU A  95
LEU A  34
 None
 0.71A 3bgdB-2qzqA:
undetectable		 3bgdB-2qzqA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tnf PROTEIN (TUMOR
NECROSIS FACTOR
ALPHA)

(Mus musculus) 		PF00229
(TNF) 		4 PHE A 152
LEU A  48
LEU A  37
LEU A  43
 None
 0.87A 3bgdB-2tnfA:
undetectable		 3bgdB-2tnfA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfh SLIT HOMOLOG 2
PROTEIN C-PRODUCT

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 THR A 820
LEU A 830
LEU A 808
LEU A 806
 None
 0.91A 3bgdB-2wfhA:
undetectable		 3bgdB-2wfhA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn1 LGPCA THIOREDOXIN

(synthetic
construct) 		PF00085
(Thioredoxin) 		4 PHE A 101
LEU A  79
LEU A  52
LEU A  23
 None
 0.86A 3bgdB-2yn1A:
undetectable		 3bgdB-2yn1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0j PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1438

(Thermus
thermophilus) 		PF04029
(2-ph_phosp) 		4 HIS A 112
LEU A 114
LEU A 131
LEU A 127
 None
 0.93A 3bgdB-2z0jA:
undetectable		 3bgdB-2z0jA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 THR A 284
LEU A 188
LEU A 268
LEU A 270
 None
 0.76A 3bgdB-3a74A:
undetectable		 3bgdB-3a74A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 GLN A 146
LEU A 152
LEU A 130
LEU A 128
 None
 0.82A 3bgdB-3ciyA:
undetectable		 3bgdB-3ciyA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF01636
(APH) 		4 PHE A  11
LEU A  89
LEU A  37
LEU A  47
 None
 0.88A 3bgdB-3csvA:
undetectable		 3bgdB-3csvA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)

(Escherichia
coli;
Homo sapiens) 		PF00085
(Thioredoxin) 		4 PHE A 446
LEU A 424
LEU A 397
LEU A 368
 None
 0.80A 3bgdB-3dxbA:
undetectable		 3bgdB-3dxbA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		4 PHE A 161
LEU A 130
LEU A  11
LEU A 143
 None
 0.91A 3bgdB-3gseA:
3.2		 3bgdB-3gseA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3r ADAPTER PROTEIN MECA
1

(Bacillus
subtilis) 		PF05389
(MecA) 		4 THR 1 152
LEU 1 131
LEU 1 142
LEU 1 182
 None
 0.91A 3bgdB-3j3r1:
undetectable		 3bgdB-3j3r1:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksu 3-OXOACYL-ACYL
CARRIER PROTEIN
REDUCTASE

(Oenococcus oeni) 		PF13561
(adh_short_C2) 		4 THR A  25
LEU A  56
LEU A  38
LEU A  36
 None
 0.76A 3bgdB-3ksuA:
6.9		 3bgdB-3ksuA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1p POU DOMAIN, CLASS 5,
TRANSCRIPTION FACTOR
1

(Mus musculus) 		PF00046
(Homeobox)
PF00157
(Pou) 		4 THR A  46
PHE A  50
LEU A  67
LEU A  34
 None
 0.93A 3bgdB-3l1pA:
undetectable		 3bgdB-3l1pA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		4 THR A  53
LEU A  63
LEU A  41
LEU A  39
 None
 0.94A 3bgdB-3m19A:
undetectable		 3bgdB-3m19A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		4 THR A  53
LEU A  65
LEU A  46
LEU A  41
 None
 0.87A 3bgdB-3m19A:
undetectable		 3bgdB-3m19A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr3 PMP2 PROTEIN

(Homo sapiens) 		PF00061
(Lipocalin) 		4 PHE A   5
LEU A  92
LEU A  67
LEU A  87
 None
 0.73A 3bgdB-3nr3A:
undetectable		 3bgdB-3nr3A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
gammaherpesvirus
4) 		no annotation 4 PHE B  89
LEU A  25
LEU A  27
LEU B  50
 None
 0.83A 3bgdB-3phfB:
undetectable		 3bgdB-3phfB:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		4 THR A  96
GLN A 100
LEU A 106
LEU A  84
 None
 0.72A 3bgdB-3t6qA:
undetectable		 3bgdB-3t6qA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tj0 NUCLEOPROTEIN

(Influenza B
virus) 		PF00506
(Flu_NP) 		4 THR A 227
PHE A 228
LEU A 215
LEU A 220
 None
 0.79A 3bgdB-3tj0A:
undetectable		 3bgdB-3tj0A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		4 PHE A   4
LEU A  91
LEU A  66
LEU A  86
 None
 0.60A 3bgdB-3wbgA:
undetectable		 3bgdB-3wbgA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 THR A 117
LEU A 127
LEU A  93
LEU A  91
 None
 0.87A 3bgdB-3wpeA:
undetectable		 3bgdB-3wpeA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhc PHYTASE

(Citrobacter
braakii) 		PF00328
(His_Phos_2) 		4 THR A  33
PHE A 172
LEU A 189
LEU A 216
 None
 0.86A 3bgdB-3zhcA:
undetectable		 3bgdB-3zhcA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 PHE A 175
LEU A 342
LEU A 247
LEU A 280
 None
 0.61A 3bgdB-4a6eA:
13.3		 3bgdB-4a6eA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5c TETRACYCLINE
REPRESSOR PROTEIN
TETR

(Proteus
mirabilis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 HIS A  44
LEU A  41
LEU A   4
LEU A  34
 None
 0.92A 3bgdB-4d5cA:
undetectable		 3bgdB-4d5cA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz4 AGMATINASE

(Burkholderia
thailandensis) 		PF00491
(Arginase) 		4 PHE A 102
LEU A  52
LEU A 173
LEU A  54
 None
 0.85A 3bgdB-4dz4A:
1.7		 3bgdB-4dz4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5v PUTATIVE THUA-LIKE
PROTEIN

(Parabacteroides
merdae) 		PF06283
(ThuA) 		4 HIS A 194
LEU A 175
LEU A 247
LEU A 231
 None
 0.87A 3bgdB-4e5vA:
undetectable		 3bgdB-4e5vA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 THR B1081
LEU B1102
LEU B1073
LEU B1105
 None
 0.85A 3bgdB-4fhnB:
undetectable		 3bgdB-4fhnB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifs FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		PF08512
(Rtt106) 		4 HIS A 363
GLN A 252
LEU A 208
LEU A 276
 None
 0.77A 3bgdB-4ifsA:
undetectable		 3bgdB-4ifsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kca ENDO-1,5-ALPHA-L-ARA
BINANASE

(Bos taurus) 		PF00085
(Thioredoxin)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 PHE A 102
LEU A  80
LEU A  53
LEU A  24
 None
 0.81A 3bgdB-4kcaA:
undetectable		 3bgdB-4kcaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw4 CYSTEINE
DESULFURATION
PROTEIN CSDE

(Escherichia
coli) 		PF02657
(SufE) 		4 HIS C   9
LEU C  44
LEU C  96
LEU C  92
 None
 0.93A 3bgdB-4lw4C:
undetectable		 3bgdB-4lw4C:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0v EXONUCLEASE SUBUNIT
SBCD

(Escherichia
coli) 		PF00149
(Metallophos)
PF12320
(SbcD_C) 		4 THR A  37
LEU A   4
LEU A 271
LEU A 257
 None
 0.35A 3bgdB-4m0vA:
undetectable		 3bgdB-4m0vA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 PHE A   4
LEU A  91
LEU A  66
LEU A  86
 None
 0.72A 3bgdB-4nnsA:
undetectable		 3bgdB-4nnsA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 4 PHE A  36
LEU A  72
LEU A  87
LEU A  78
 None
 0.65A 3bgdB-4oj5A:
undetectable		 3bgdB-4oj5A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		4 THR A 126
LEU A 136
LEU A 113
LEU A 111
 None
 0.92A 3bgdB-4p8sA:
undetectable		 3bgdB-4p8sA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q16 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Deinococcus
radiodurans) 		PF02540
(NAD_synthase) 		4 THR A 174
PHE A 261
LEU A 244
LEU A  19
 None
 0.73A 3bgdB-4q16A:
undetectable		 3bgdB-4q16A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 4 PHE A  36
LEU A  72
LEU A  87
LEU A  78
 None
 0.66A 3bgdB-4qnlA:
3.2		 3bgdB-4qnlA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtu PUTATIVE
METHYLTRANSFERASE
BUD23

(Saccharomyces
cerevisiae) 		PF08241
(Methyltransf_11) 		4 HIS B  71
LEU B  40
LEU B  45
LEU B  43
 EDO  B 309 ( 4.0A)
EDO  B 309 ( 4.3A)
EDO  B 309 (-4.6A)
None
 0.86A 3bgdB-4qtuB:
14.1		 3bgdB-4qtuB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v36 LYSYL-TRNA-DEPENDENT
L-YSYL-PHOSPHATIDYLG
YCEROL SYNTHASE

(Bacillus
licheniformis) 		PF09924
(DUF2156) 		4 GLN A 611
LEU A 579
LEU A 549
LEU A 546
 None
 0.81A 3bgdB-4v36A:
1.8		 3bgdB-4v36A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 PHE A  50
GLN A  40
LEU A 120
LEU A  94
 None
 0.83A 3bgdB-4yh7A:
undetectable		 3bgdB-4yh7A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		4 THR A  97
LEU A 107
LEU A  85
LEU A  83
 None
 0.93A 3bgdB-5a5cA:
undetectable		 3bgdB-5a5cA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b29 FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		4 PHE A   4
LEU A  91
LEU A  66
LEU A  86
 None
 0.71A 3bgdB-5b29A:
undetectable		 3bgdB-5b29A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II) 		4 THR A 340
GLN A 251
LEU A 392
LEU A 248
 None
 0.92A 3bgdB-5b47A:
undetectable		 3bgdB-5b47A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN

(Pygoscelis
papua) 		PF00061
(Lipocalin) 		4 PHE A   7
LEU A  95
LEU A  69
LEU A  89
 None
 0.77A 3bgdB-5bvtA:
undetectable		 3bgdB-5bvtA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 GLN A  58
LEU A  60
LEU A  99
LEU A  88
 None
 0.67A 3bgdB-5c2vA:
undetectable		 3bgdB-5c2vA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5h 2-SUCCINYLBENZOATE--
COA LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLN A 227
LEU A 231
LEU A 215
LEU A 211
 None
 0.87A 3bgdB-5c5hA:
undetectable		 3bgdB-5c5hA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		4 PHE A 264
GLN A 224
LEU A 226
LEU A 236
 None
 0.76A 3bgdB-5cvoA:
undetectable		 3bgdB-5cvoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE

(Bacteroides
fragilis) 		PF03415
(Peptidase_C11) 		4 PHE A 120
LEU A  36
LEU A  82
LEU A  71
 None
 0.84A 3bgdB-5dynA:
undetectable		 3bgdB-5dynA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fah KALLIKREIN-7

(Homo sapiens) 		PF00089
(Trypsin) 		4 HIS A  67
LEU A  34
LEU A  73
LEU A  40
 None
 0.82A 3bgdB-5fahA:
undetectable		 3bgdB-5fahA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl3 PILI RETRACTION
PROTEIN PILT

(Thermus
thermophilus) 		PF00437
(T2SSE) 		4 THR A 148
GLN A 276
LEU A 278
LEU A 289
 ADP  A 400 (-3.3A)
None
ADP  A 400 (-4.5A)
ADP  A 400 ( 3.8A)
 0.72A 3bgdB-5fl3A:
2.3		 3bgdB-5fl3A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		4 PHE A 188
GLN A 235
LEU A 237
LEU A 179
 None
 0.66A 3bgdB-5fx8A:
undetectable		 3bgdB-5fx8A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		4 PHE A 188
LEU A 237
LEU A 179
LEU A 214
 None
 0.51A 3bgdB-5fx8A:
undetectable		 3bgdB-5fx8A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 5 HIS A 321
THR A 302
LEU A  31
LEU A 341
LEU A 339
 None
 1.21A 3bgdB-5fzpA:
undetectable		 3bgdB-5fzpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikn THIOREDOXIN-1

(Escherichia
coli) 		PF00085
(Thioredoxin) 		4 PHE K 102
LEU K  80
LEU K  53
LEU K  24
 None
 0.85A 3bgdB-5iknK:
undetectable		 3bgdB-5iknK:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 PHE B 209
LEU B 189
LEU B 244
LEU B 219
 None
 0.91A 3bgdB-5iz5B:
undetectable		 3bgdB-5iz5B:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		4 PHE B 264
GLN B 224
LEU B 226
LEU B 236
 None
 0.56A 3bgdB-5k1cB:
undetectable		 3bgdB-5k1cB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpo MOLYBDOPTERIN
SYNTHASE SULFUR
CARRIER SUBUNIT

(Homo sapiens) 		PF02597
(ThiS) 		4 PHE A  57
LEU A  37
LEU A  73
LEU A  71
 None
 0.88A 3bgdB-5mpoA:
undetectable		 3bgdB-5mpoA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 4 PHE A 451
LEU A 566
LEU A 528
LEU A 403
 None
 0.80A 3bgdB-5n4lA:
undetectable		 3bgdB-5n4lA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfi MINOR FIMBRIUM
ANCHORING SUBUNIT
MFA2

(Porphyromonas
gingivalis) 		no annotation 4 PHE B 239
LEU B 202
LEU B 268
LEU B 252
 None
 0.88A 3bgdB-5nfiB:
undetectable		 3bgdB-5nfiB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 4 THR A 125
LEU A 135
LEU A 112
LEU A 110
 None
 0.79A 3bgdB-5o0lA:
undetectable		 3bgdB-5o0lA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 4 THR A 173
LEU A 183
LEU A 161
LEU A 159
 None
 0.88A 3bgdB-5o0lA:
undetectable		 3bgdB-5o0lA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 4 THR A 173
LEU A 185
LEU A 166
LEU A 161
 None
 0.88A 3bgdB-5o0lA:
undetectable		 3bgdB-5o0lA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 THR A  34
PHE A  35
LEU A 371
LEU A 418
 None
 0.90A 3bgdB-5oasA:
undetectable		 3bgdB-5oasA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		no annotation 4 HIS A 363
GLN A 252
LEU A 208
LEU A 276
 None
 0.81A 3bgdB-5umsA:
undetectable		 3bgdB-5umsA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoc THIOREDOXIN
1,FORKHEAD BOX
PROTEIN H1

(Escherichia
coli;
Homo sapiens) 		no annotation 4 PHE B 313
LEU B 291
LEU B 264
LEU B 235
 None
 0.81A 3bgdB-5xocB:
undetectable		 3bgdB-5xocB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 4 THR A 118
LEU A 128
LEU A  94
LEU A  92
 None
 0.84A 3bgdB-5y3jA:
undetectable		 3bgdB-5y3jA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 4 THR A 647
LEU A 635
LEU A 640
LEU A 610
 None
 0.92A 3bgdB-5y3jA:
undetectable		 3bgdB-5y3jA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 THR A 118
LEU A 128
LEU A  94
LEU A  92
 None
 0.94A 3bgdB-5zlnA:
undetectable		 3bgdB-5zlnA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ank SYNAPTOTAGMIN-7

(Rattus
norvegicus) 		PF00168
(C2) 		4 PHE A 206
LEU A 179
LEU A 242
LEU A 219
 None
 0.76A 3bgdB-6ankA:
undetectable		 3bgdB-6ankA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 4 PHE A 118
LEU A 150
LEU A 155
LEU A 153
 None
 0.90A 3bgdB-6cr0A:
undetectable		 3bgdB-6cr0A:
15.88