SIMILAR PATTERNS OF AMINO ACIDS FOR 3BF6_H_SVRH301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		6 HIS H  91
PRO H  92
ARG H  93
ARG H 101
TRP H 237
VAL H 241
 None
 0.93A 3bf6H-1id5H:
42.5		 3bf6H-1id5H:
87.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mkx PRETHROMBIN-2

(Bos taurus) 		PF00089
(Trypsin)
PF09396
(Thrombin_light) 		6 HIS K  91
PRO K  92
ARG K  93
ARG K 101
TRP K 237
VAL K 241
 None
 0.77A 3bf6H-1mkxK:
35.7		 3bf6H-1mkxK:
87.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		5 ARG A  85
VAL A 150
GLN A 151
GLY A 308
GLU A 299
 None
 1.30A 3bf6H-1mnnA:
undetectable		 3bf6H-1mnnA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukm EMS16 A CHAIN
EMS16 B CHAIN

(Echis
multisquamatus) 		PF00059
(Lectin_C) 		5 PRO B  70
LYS A 102
GLN A 105
GLY A  71
GLU A  29
 None
GOL  B1303 (-3.0A)
None
None
None
 1.10A 3bf6H-1ukmB:
undetectable		 3bf6H-1ukmB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 HIS A 198
PRO A 195
TRP A 194
VAL A 278
GLY A 288
 None
 1.03A 3bf6H-2gt1A:
undetectable		 3bf6H-2gt1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 HIS A 198
PRO A 195
TRP A 194
VAL A 278
GLY A 289
 None
 0.91A 3bf6H-2gt1A:
undetectable		 3bf6H-2gt1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 ARG A 369
TRP A 362
LYS A 184
VAL A 183
GLU A 348
 None
None
6PG  A1471 (-2.6A)
None
None
 1.47A 3bf6H-2iyoA:
undetectable		 3bf6H-2iyoA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnp FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 PRO F  86
ARG F  87
VAL F 115
GLY F 155
GLU F 156
 None
 1.43A 3bf6H-2wnpF:
undetectable		 3bf6H-2wnpF:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgh GRANZYME M

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  74
PRO A  75
TRP A 223
LYS A 226
VAL A 227
 None
 0.64A 3bf6H-2zghA:
32.1		 3bf6H-2zghA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		5 ARG A 153
ARG A 156
GLN A  61
GLY A  49
GLU A  47
 None
 1.24A 3bf6H-3bjdA:
undetectable		 3bf6H-3bjdA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		5 HIS A 190
PRO A 100
VAL A 477
GLY A 341
GLU A 343
 FMN  A 700 (-4.1A)
FMN  A 700 (-4.1A)
None
None
None
 1.36A 3bf6H-3eo7A:
undetectable		 3bf6H-3eo7A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 TRP B 883
LYS B 790
VAL B 791
GLY A 232
GLU A 234
 None
 1.39A 3bf6H-3hs0B:
undetectable		 3bf6H-3hs0B:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lga SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
abyssi) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		5 HIS A 204
PRO A 217
VAL A 177
GLY A 157
GLU A 156
 None
 1.47A 3bf6H-3lgaA:
undetectable		 3bf6H-3lgaA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		7 HIS A 491
ARG A 493
ARG A 501
TRP A 637
LYS A 640
VAL A 641
GLN A 644
 None
None
None
GOL  A 704 (-4.4A)
None
GOL  A 704 ( 4.4A)
GOL  A 704 (-3.0A)
 1.01A 3bf6H-3nxpA:
29.8		 3bf6H-3nxpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nxp PRETHROMBIN-1

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		6 HIS A 491
ARG A 501
TRP A 637
VAL A 641
GLN A 644
GLU A 647
 None
None
GOL  A 704 (-4.4A)
GOL  A 704 ( 4.4A)
GOL  A 704 (-3.0A)
None
 1.09A 3bf6H-3nxpA:
29.8		 3bf6H-3nxpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS B  91
ARG B  93
ARG B 101
TRP B 237
LYS B 240
 None
 1.37A 3bf6H-3r3gB:
43.0		 3bf6H-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS B  91
PRO B  92
ARG B  93
ARG B 101
TRP B 237
VAL B 241
 None
 0.90A 3bf6H-3r3gB:
43.0		 3bf6H-3r3gB:
97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		6 HIS B  91
PRO B  92
ARG B 101
TRP B 237
VAL B 241
GLN B 244
 None
 0.85A 3bf6H-3r3gB:
43.0		 3bf6H-3r3gB:
97.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 PRO A 431
ARG A 430
GLN A 347
GLY A 345
GLU A 343
 None
None
None
CA  A 501 (-4.1A)
None
 1.37A 3bf6H-3tiaA:
undetectable		 3bf6H-3tiaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 PRO A 475
TRP A 324
VAL A 328
GLN A 331
GLU A 338
 None
 1.28A 3bf6H-3to3A:
undetectable		 3bf6H-3to3A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		5 PRO A 377
ARG A 378
VAL A 440
GLN A 496
GLY A 552
 None
 1.18A 3bf6H-4conA:
undetectable		 3bf6H-4conA:
17.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  91
PRO A  92
TRP A 237
VAL A 241
GLU A  49
 None
 1.24A 3bf6H-4d9rA:
18.1		 3bf6H-4d9rA:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 PRO A 431
ARG A 430
GLN A 347
GLY A 345
GLU A 343
 None
None
None
CA  A 501 (-4.0A)
None
 1.41A 3bf6H-4h53A:
undetectable		 3bf6H-4h53A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzh PROTHROMBIN

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		7 HIS A 407
ARG A 418
TRP A 569
LYS A 572
VAL A 573
GLN A 576
GLU A 579
 None
 1.47A 3bf6H-4hzhA:
29.5		 3bf6H-4hzhA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzh PROTHROMBIN

(Homo sapiens) 		PF00051
(Kringle)
PF00089
(Trypsin)
PF09396
(Thrombin_light) 		8 HIS A 407
PRO A 408
ARG A 409
ARG A 418
TRP A 569
LYS A 572
VAL A 573
GLU A 579
 None
 1.24A 3bf6H-4hzhA:
29.5		 3bf6H-4hzhA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 PRO A 423
ARG A 422
GLN A 428
GLY A 470
GLU A 471
 None
 1.40A 3bf6H-4l68A:
undetectable		 3bf6H-4l68A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqk LECTIN 2

(Agrocybe
aegerita) 		PF13517
(VCBS) 		5 HIS A 173
ARG A 169
ARG A 172
VAL A 196
GLY A 261
 NAG  A 503 (-3.9A)
None
None
None
None
 1.45A 3bf6H-4tqkA:
undetectable		 3bf6H-4tqkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN

(Homo sapiens) 		PF07522
(DRMBL)
PF12706
(Lactamase_B_2) 		5 ARG A1002
LYS A1008
VAL A 832
GLN A 830
GLY A 807
 None
None
EDO  A2042 ( 4.7A)
None
None
 1.32A 3bf6H-5ahrA:
undetectable		 3bf6H-5ahrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ARG A 725
ARG A 781
VAL A 767
GLY A 507
GLU A 509
 None
 1.23A 3bf6H-5h53A:
undetectable		 3bf6H-5h53A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iai SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF01547
(SBP_bac_1) 		5 PRO A 173
VAL A 176
GLN A 216
GLY A 219
GLU A 234
 None
 1.48A 3bf6H-5iaiA:
undetectable		 3bf6H-5iaiA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 HIS A 186
ARG A 181
ARG A 185
VAL A 151
GLY A 159
 None
 1.32A 3bf6H-5jd5A:
undetectable		 3bf6H-5jd5A:
22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lpe KALLIKREIN-10

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  91
PRO A  92
TRP A 237
LYS A 240
VAL A 241
 None
 0.69A 3bf6H-5lpeA:
11.7		 3bf6H-5lpeA:
31.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		5 PRO B 614
ARG B 562
VAL B 579
GLY B 634
GLU B 633
 None
None
EDO  B 710 (-4.3A)
None
None
 1.42A 3bf6H-5lxzB:
undetectable		 3bf6H-5lxzB:
17.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		7 HIS B 102
PRO B 103
ARG B 104
ARG B 113
TRP B 264
VAL B 268
GLY B 275
 None
 1.41A 3bf6H-5to3B:
45.1		 3bf6H-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		6 HIS B 102
PRO B 103
ARG B 104
TRP B 264
VAL B 268
GLY B 274
 None
 0.99A 3bf6H-5to3B:
45.1		 3bf6H-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		5 HIS B 102
PRO B 103
TRP B 264
LYS B 267
VAL B 268
 None
 1.00A 3bf6H-5to3B:
45.1		 3bf6H-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		6 HIS B 102
PRO B 103
TRP B 264
VAL B 268
GLN B 271
GLY B 274
 None
 1.38A 3bf6H-5to3B:
45.1		 3bf6H-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		5 PRO B 103
ARG B 104
TRP B 264
VAL B 268
GLY B 274
 None
 1.38A 3bf6H-5to3B:
45.1		 3bf6H-5to3B:
88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 5 HIS A 511
PRO A 512
TRP A 674
LYS A 677
GLU A 467
 None
 1.39A 3bf6H-5ubmA:
32.1		 3bf6H-5ubmA:
35.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 PRO 2 264
LYS 2 431
VAL 2 318
GLY 2 322
GLU 2 392
 None
 1.33A 3bf6H-5udb2:
undetectable		 3bf6H-5udb2:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2v L-METHIONINE
GAMMA-LYASE

(Pseudomonas
putida) 		PF01053
(Cys_Met_Meta_PP) 		5 HIS A 350
PRO A 351
ARG A 364
GLY A 293
GLU A 278
 None
 1.44A 3bf6H-5x2vA:
undetectable		 3bf6H-5x2vA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyf TERF1-INTERACTING
NUCLEAR FACTOR 2

(Homo sapiens) 		no annotation 5 HIS A  85
LYS A  62
VAL A  65
GLY A 140
GLU A 136
 None
 1.48A 3bf6H-5xyfA:
undetectable		 3bf6H-5xyfA:
11.55