SIMILAR PATTERNS OF AMINO ACIDS FOR 3BBT_D_FMMD91_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  86
ALA A  99
LYS A 101
GLY A 153
LEU A 201
ASP A 212
PHE A 213
 ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
MG  A 536 (-3.3A)
5EA  A1001 (-3.6A)
 0.41A 3bbtD-1s9iA:
17.1		 3bbtD-1s9iA:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 377
ALA A 389
LYS A 391
LEU A 433
GLY A 441
LEU A 489
ASP A 500
PHE A 501
 None
 0.75A 3bbtD-1snxA:
24.8		 3bbtD-1snxA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 352
ALA A 367
LEU A 412
GLY A 420
LEU A 468
ASP A 479
PHE A 480
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
None
 1.06A 3bbtD-1u59A:
29.7		 3bbtD-1u59A:
35.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  30
LYS A  32
LEU A  77
LEU A 132
ASP A 143
LEU A 146
 None
 0.69A 3bbtD-1v0bA:
24.4		 3bbtD-1v0bA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 281
ALA A 293
LYS A 295
MET A 314
THR A 338
GLY A 344
LEU A 393
ASP A 404
LEU A 407
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
None
 0.93A 3bbtD-2h8hA:
32.7		 3bbtD-2h8hA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 281
ALA A 293
LYS A 295
THR A 338
GLY A 344
LEU A 393
ASP A 404
PHE A 405
LEU A 407
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
None
None
 0.89A 3bbtD-2h8hA:
32.7		 3bbtD-2h8hA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
LEU A 393
ASP A 404
PHE A 405
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
 0.82A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
LYS A 295
MET A 314
THR A 338
GLY A 344
LEU A 393
ASP A 404
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
 0.70A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 281
LYS A 295
MET A 314
GLY A 344
LEU A 393
ASP A 404
PHE A 405
LEU A 407
 QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
None
 1.13A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 281
LYS A 295
MET A 314
THR A 338
GLY A 344
LEU A 393
ASP A 404
LEU A 407
 QUE  A   1 ( 4.8A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
None
None
 0.99A 3bbtD-2hckA:
32.2		 3bbtD-2hckA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 VAL A 352
ALA A 367
LYS A 369
MET A 390
GLY A 419
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
MG  A 614 ( 3.2A)
None
None
 0.97A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 VAL A 352
ALA A 367
LYS A 369
MET A 390
LEU A 412
GLY A 418
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 ( 4.0A)
MG  A 614 ( 3.2A)
None
None
 1.05A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 VAL A 352
ALA A 367
LYS A 369
MET A 390
LEU A 412
GLY A 420
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 ( 3.9A)
MG  A 614 ( 3.2A)
None
None
 1.04A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 VAL A 352
ALA A 367
MET A 390
GLY A 419
LEU A 468
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
None
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
None
None
 1.08A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 VAL A 352
ALA A 367
MET A 390
LEU A 412
GLY A 418
LEU A 468
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
None
ANP  A 615 ( 4.0A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
None
None
 1.28A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 VAL A 352
ALA A 367
MET A 390
LEU A 412
GLY A 420
LEU A 468
ASP A 479
PHE A 480
LEU A 482
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
None
None
 0.96A 3bbtD-2ozoA:
31.8		 3bbtD-2ozoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		7 VAL B  55
ALA B  67
LEU B 112
GLY B 120
LEU B 171
THR B 181
PHE B 183
 None
 0.70A 3bbtD-2qkwB:
22.7		 3bbtD-2qkwB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
LEU A 263
GLY A 271
LEU A 328
ASP A 339
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.93A 3bbtD-2qluA:
24.6		 3bbtD-2qluA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
LYS A 217
LEU A 263
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.82A 3bbtD-2qluA:
24.6		 3bbtD-2qluA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
LYS A 217
THR A 265
GLY A 271
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.75A 3bbtD-2qluA:
24.6		 3bbtD-2qluA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
THR A 265
GLY A 271
LEU A 328
ASP A 339
PHE A 340
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
None
 0.87A 3bbtD-2qluA:
24.6		 3bbtD-2qluA:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 MET A 772
GLY A 802
LEU A 850
THR A 860
ASP A 861
PHE A 862
LEU A 864
 GW7  A   1 ( 3.8A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.8A)
GW7  A   1 ( 4.7A)
 1.12A 3bbtD-2r4bA:
38.2		 3bbtD-2r4bA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 732
ALA A 749
LYS A 751
LEU A 794
THR A 796
GLY A 802
LEU A 850
THR A 860
ASP A 861
PHE A 862
LEU A 864
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.8A)
GW7  A   1 ( 4.7A)
 0.68A 3bbtD-2r4bA:
38.2		 3bbtD-2r4bA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  38
ALA A  51
LYS A  53
GLY A 113
LEU A 160
ASP A 171
PHE A 172
 None
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
None
 1.08A 3bbtD-2y7jA:
22.5		 3bbtD-2y7jA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  76
ALA A  92
LEU A 139
GLY A 147
LEU A 194
THR A 204
PHE A 206
 None
STU  A   1 (-3.3A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
None
 0.77A 3bbtD-2z7rA:
23.0		 3bbtD-2z7rA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  76
ALA A  92
LYS A  94
LEU A 139
GLY A 147
LEU A 194
THR A 204
 None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
 0.84A 3bbtD-2z7rA:
23.0		 3bbtD-2z7rA:
24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
PHE A 642
LEU A 644
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
C4F  A   1 ( 4.5A)
None
 1.19A 3bbtD-3c4fA:
29.9		 3bbtD-3c4fA:
33.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 158
ALA A 169
LEU A 218
GLY A 226
LEU A 275
THR A 293
PHE A 295
 VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-3.4A)
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
None
 0.39A 3bbtD-3dtcA:
29.4		 3bbtD-3dtcA:
31.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		8 VAL A  37
ALA A  50
LEU A  98
GLY A 106
LEU A 153
ASP A 167
PHE A 168
LEU A 170
 None
 0.86A 3bbtD-3dxnA:
25.3		 3bbtD-3dxnA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 VAL A 234
ALA A 247
GLY A 307
LEU A 354
THR A 367
ASP A 368
PHE A 369
 None
 0.72A 3bbtD-3i6uA:
22.8		 3bbtD-3i6uA:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 704
LYS A 723
LEU A 766
THR A 768
GLY A 774
LEU A 822
ASP A 833
PHE A 834
 ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.8A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
MG  A1001 ( 3.1A)
None
 0.61A 3bbtD-3kexA:
36.0		 3bbtD-3kexA:
58.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
THR A 713
GLY A 719
LEU A 767
ASP A 778
PHE A 779
 None
None
None
GOL  A 403 (-3.4A)
None
None
None
 0.96A 3bbtD-3kulA:
30.8		 3bbtD-3kulA:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  47
ALA A  60
LYS A  62
LEU A 108
GLY A 116
LEU A 165
ASP A 179
PHE A 180
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
None
QUE  A   1 (-2.9A)
None
 0.97A 3bbtD-3lm5A:
12.6		 3bbtD-3lm5A:
24.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 719
LEU A 764
GLY A 772
LEU A 820
THR A 830
ASP A 831
PHE A 832
LEU A 834
 ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
 0.88A 3bbtD-3lzbA:
37.8		 3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 719
LEU A 764
THR A 766
GLY A 772
LEU A 820
THR A 830
ASP A 831
PHE A 832
 ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
 0.91A 3bbtD-3lzbA:
37.8		 3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 719
MET A 742
GLY A 772
LEU A 820
THR A 830
ASP A 831
PHE A 832
LEU A 834
 ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
 1.07A 3bbtD-3lzbA:
37.8		 3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 719
MET A 742
THR A 766
GLY A 772
LEU A 820
THR A 830
ASP A 831
PHE A 832
 ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
 1.03A 3bbtD-3lzbA:
37.8		 3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 702
ALA A 719
LEU A 764
LEU A 820
THR A 830
ASP A 831
PHE A 832
LEU A 834
 ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
 0.84A 3bbtD-3lzbA:
37.8		 3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 702
ALA A 719
LEU A 764
THR A 766
LEU A 820
THR A 830
ASP A 831
PHE A 832
 ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
 0.87A 3bbtD-3lzbA:
37.8		 3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 702
ALA A 719
LYS A 721
LEU A 764
ASP A 831
PHE A 832
LEU A 834
 ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 ( 4.2A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
 1.03A 3bbtD-3lzbA:
37.8		 3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 702
ALA A 719
LYS A 721
LEU A 764
THR A 766
ASP A 831
PHE A 832
 ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
 1.04A 3bbtD-3lzbA:
37.8		 3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 702
ALA A 719
MET A 742
LEU A 820
THR A 830
ASP A 831
PHE A 832
LEU A 834
 ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
None
 1.04A 3bbtD-3lzbA:
37.8		 3bbtD-3lzbA:
69.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 702
ALA A 719
MET A 742
THR A 766
LEU A 820
THR A 830
ASP A 831
PHE A 832
 ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
ITI  A   1 (-3.6A)
 1.00A 3bbtD-3lzbA:
37.8		 3bbtD-3lzbA:
69.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 VAL A 218
ALA A 229
LEU A 277
THR A 279
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.88A 3bbtD-3mdyA:
24.7		 3bbtD-3mdyA:
25.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A1096
ALA A1112
LYS A1114
MET A1135
GLY A1167
ASP A1226
PHE A1227
LEU A1229
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
None
MG  A   1 ( 3.2A)
None
None
 0.80A 3bbtD-3plsA:
15.6		 3bbtD-3plsA:
35.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 734
ALA A 751
LYS A 753
LEU A 796
GLY A 804
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.87A 3bbtD-3pp0A:
35.8		 3bbtD-3pp0A:
73.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 734
ALA A 751
LYS A 753
LEU A 796
THR A 798
GLY A 804
LEU A 852
THR A 862
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.64A 3bbtD-3pp0A:
35.8		 3bbtD-3pp0A:
73.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 206
ALA A 217
LEU A 265
THR A 267
GLY A 273
LEU A 329
ASP A 340
PHE A 341
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
None
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
None
None
 1.00A 3bbtD-3q4tA:
24.0		 3bbtD-3q4tA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 VAL A  65
ALA A  78
LYS A  80
LEU A 126
LEU A 181
ASP A 195
LEU A 198
 BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 (-4.0A)
BK5  A 701 ( 4.9A)
 0.89A 3bbtD-3sxfA:
23.9		 3bbtD-3sxfA:
23.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
LYS A 514
GLY A 567
LEU A 630
ASP A 641
PHE A 642
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.6A)
 1.01A 3bbtD-3tt0A:
29.7		 3bbtD-3tt0A:
31.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  83
ALA A  96
LYS A  98
GLY A 150
LEU A 198
ASP A 209
PHE A 210
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
CHU  A 403 (-3.8A)
 0.56A 3bbtD-3wigA:
24.5		 3bbtD-3wigA:
25.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLY A 922
LEU A1035
ASP A1046
PHE A1047
LEU A1049
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
LEV  A1201 (-3.3A)
LEV  A1201 ( 4.5A)
 0.85A 3bbtD-3wzdA:
29.5		 3bbtD-3wzdA:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 222
ALA A 233
LYS A 235
LEU A 281
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.84A 3bbtD-4c02A:
19.5		 3bbtD-4c02A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 222
ALA A 233
LYS A 235
THR A 283
GLY A 289
LEU A 343
ASP A 354
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.71A 3bbtD-4c02A:
19.5		 3bbtD-4c02A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 VAL A 254
ALA A 267
GLY A 324
LEU A 371
THR A 381
ASP A 382
PHE A 383
 None
 1.03A 3bbtD-4c0tA:
20.3		 3bbtD-4c0tA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 VAL A 385
ALA A 400
LYS A 402
LEU A 446
GLY A 454
LEU A 501
ASP A 512
PHE A 513
LEU A 515
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
None
None
 0.82A 3bbtD-4fl3A:
24.6		 3bbtD-4fl3A:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 863
ALA A 880
LYS A 882
LEU A 927
GLY A 935
LEU A 983
PHE A 995
 None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
None
 1.11A 3bbtD-4gl9A:
23.0		 3bbtD-4gl9A:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 863
LYS A 882
LEU A 927
GLY A 935
LEU A 983
ASP A 994
PHE A 995
 None
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
None
 1.29A 3bbtD-4gl9A:
23.0		 3bbtD-4gl9A:
32.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 VAL A 140
ALA A 156
LYS A 158
GLY A 211
LEU A 259
ASP A 270
PHE A 271
LEU A 273
 None
 0.65A 3bbtD-4hzsA:
23.2		 3bbtD-4hzsA:
36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		9 VAL A 140
ALA A 156
MET A 181
THR A 205
GLY A 211
LEU A 259
ASP A 270
PHE A 271
LEU A 273
 None
 0.85A 3bbtD-4hzsA:
23.2		 3bbtD-4hzsA:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  26
ALA A  39
LYS A  41
LEU A  87
GLY A  95
LEU A 143
PHE A 155
 631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
None
 0.74A 3bbtD-4jxfA:
19.1		 3bbtD-4jxfA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
LYS A 295
GLY A 344
LEU A 393
ASP A 404
PHE A 405
LEU A 407
 0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
None
None
 0.67A 3bbtD-4k11A:
32.8		 3bbtD-4k11A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
MET A 314
GLY A 344
LEU A 393
ASP A 404
PHE A 405
 0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
None
 0.60A 3bbtD-4k11A:
32.8		 3bbtD-4k11A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l68 LEUCINE-RICH REPEAT
PROTEIN KINASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 333
LYS A 335
LEU A 377
GLY A 385
LEU A 436
ASP A 447
LEU A 450
 None
 1.02A 3bbtD-4l68A:
22.7		 3bbtD-4l68A:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		11 VAL A  36
ALA A  49
LYS A  51
MET A  65
LEU A  93
THR A  95
GLY A 101
LEU A 150
ASP A 161
PHE A 162
LEU A 164
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
ANP  A 401 (-3.8A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
None
None
 0.66A 3bbtD-4m69A:
19.1		 3bbtD-4m69A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  54
ALA A  67
LEU A 121
THR A 123
GLY A 128
LEU A 180
PHE A 192
 None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.77A 3bbtD-4o38A:
18.8		 3bbtD-4o38A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  54
ALA A  67
LYS A  69
LEU A 121
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.84A 3bbtD-4o38A:
18.8		 3bbtD-4o38A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		7 VAL A  27
ALA A  40
LYS A  42
LEU A 148
THR A 158
ASP A 159
PHE A 160
 None
 1.15A 3bbtD-4ow8A:
24.4		 3bbtD-4ow8A:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 158
ALA A 169
GLY A 226
LEU A 275
THR A 293
ASP A 294
PHE A 295
 None
 0.69A 3bbtD-4uy9A:
27.4		 3bbtD-4uy9A:
33.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 158
ALA A 169
LEU A 218
GLY A 226
LEU A 275
THR A 293
PHE A 295
 None
 0.84A 3bbtD-4uy9A:
27.4		 3bbtD-4uy9A:
33.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 158
ALA A 169
LYS A 171
LEU A 218
GLY A 226
LEU A 275
THR A 293
 None
 1.23A 3bbtD-4uy9A:
27.4		 3bbtD-4uy9A:
33.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 138
ALA A 149
LEU A 198
GLY A 206
LEU A 270
THR A 288
PHE A 290
 AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
None
AGS  A1438 (-4.7A)
AGS  A1438 ( 4.7A)
None
 0.61A 3bbtD-4uyaA:
20.7		 3bbtD-4uyaA:
34.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 VAL A 112
ALA A 125
LYS A 127
GLY A 181
LEU A 228
THR A 238
PHE A 240
 ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.5A)
ATP  A 501 (-3.1A)
None
 1.23A 3bbtD-4wb7A:
21.2		 3bbtD-4wb7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 416
ALA A 428
MET A 449
THR A 474
GLY A 480
LEU A 528
ASP A 539
PHE A 540
LEU A 542
 None
 0.90A 3bbtD-4xi2A:
27.0		 3bbtD-4xi2A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 VAL A 416
ALA A 428
MET A 449
THR A 474
GLY A 480
LEU A 528
ASP A 539
PHE A 540
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-3.7A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 (-3.7A)
None
 0.79A 3bbtD-4y93A:
31.5		 3bbtD-4y93A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
ALA A  31
LEU A  78
LEU A 135
ASP A 146
PHE A 147
LEU A 149
 None
 0.73A 3bbtD-4yc6A:
24.6		 3bbtD-4yc6A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 VAL A  42
ALA A  55
LEU A 103
THR A 105
GLY A 111
LEU A 158
PHE A 173
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
None
 0.98A 3bbtD-4ysjA:
23.7		 3bbtD-4ysjA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 VAL A  42
ALA A  55
LYS A  57
LEU A 103
THR A 105
GLY A 111
LEU A 158
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
 1.01A 3bbtD-4ysjA:
23.7		 3bbtD-4ysjA:
22.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLY A 567
LEU A 630
ASP A 641
PHE A 642
LEU A 644
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
EDO  A1766 (-3.7A)
None
 0.99A 3bbtD-5a46A:
28.1		 3bbtD-5a46A:
34.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
LYS A 514
GLY A 567
LEU A 630
ASP A 641
LEU A 644
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
None
 1.11A 3bbtD-5a46A:
28.1		 3bbtD-5a46A:
34.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  44
LEU A  90
GLY A  98
LEU A 145
ASP A 165
PHE A 166
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
None
 0.90A 3bbtD-5ci7A:
22.5		 3bbtD-5ci7A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  44
LYS A  46
LEU A  90
GLY A  98
LEU A 145
ASP A 165
 51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 (-3.7A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
 1.06A 3bbtD-5ci7A:
22.5		 3bbtD-5ci7A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  39
ALA A  52
LEU A 103
GLY A 111
LEU A 160
ASP A 171
PHE A 172
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LEU  A 103 ( 0.6A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
PHE  A 172 ( 1.3A)
 0.76A 3bbtD-5d7aA:
24.7		 3bbtD-5d7aA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 258
ALA A 275
LEU A 323
THR A 325
GLY A 331
LEU A 386
PHE A 398
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
None
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
None
 0.80A 3bbtD-5e8yA:
19.8		 3bbtD-5e8yA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 258
ALA A 275
LYS A 277
LEU A 323
THR A 325
GLY A 331
LEU A 386
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
None
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.71A 3bbtD-5e8yA:
19.8		 3bbtD-5e8yA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		7 VAL A  32
ALA A  45
LYS A  47
LEU A  92
GLY A 100
LEU A 147
THR A 160
 None
 1.11A 3bbtD-5ig1A:
23.0		 3bbtD-5ig1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  43
MET A  64
GLY A  96
LEU A 143
ASP A 154
PHE A 155
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
None
 1.13A 3bbtD-5j5tA:
21.8		 3bbtD-5j5tA:
25.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 726
ALA A 743
LYS A 745
GLY A 796
LEU A 844
THR A 854
PHE A 856
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
None
 1.00A 3bbtD-5j9zA:
33.8		 3bbtD-5j9zA:
77.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 726
ALA A 743
LYS A 745
LEU A 788
GLY A 796
LEU A 844
THR A 854
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.81A 3bbtD-5j9zA:
33.8		 3bbtD-5j9zA:
77.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 284
ALA A 297
LYS A 299
GLY A 350
LEU A 396
THR A 406
PHE A 408
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
None
 0.82A 3bbtD-5kbrA:
22.3		 3bbtD-5kbrA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  49
ALA A  60
LEU A 108
GLY A 116
LEU A 163
THR A 173
PHE A 175
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
None
 0.55A 3bbtD-5lohA:
18.4		 3bbtD-5lohA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 VAL A 897
ALA A 909
LYS A 911
LEU A 954
GLY A 962
LEU A1016
PHE A1028
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
None
 1.04A 3bbtD-5lpyA:
22.8		 3bbtD-5lpyA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 VAL A 897
LYS A 911
LEU A 954
GLY A 962
LEU A1016
ASP A1027
PHE A1028
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
None
 1.19A 3bbtD-5lpyA:
22.8		 3bbtD-5lpyA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 VAL A 897
ALA A 909
LYS A 911
LEU A 954
GLY A 962
LEU A1016
PHE A1028
 ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
None
 1.07A 3bbtD-5lpzA:
22.7		 3bbtD-5lpzA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 10 VAL A 899
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
THR A1027
ASP A1028
PHE A1029
LEU A1031
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
None
None
 0.70A 3bbtD-5wnoA:
35.1		 3bbtD-5wnoA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 7 ALA A 225
LYS A 227
GLY A 279
LEU A 326
THR A 338
ASP A 339
PHE A 340
 None
 1.25A 3bbtD-5xzwA:
19.0		 3bbtD-5xzwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 7 VAL A 212
ALA A 225
GLY A 279
LEU A 326
THR A 338
ASP A 339
PHE A 340
 None
 1.01A 3bbtD-5xzwA:
19.0		 3bbtD-5xzwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 VAL A  41
ALA A  54
LYS A  56
GLY A 105
LEU A 153
ASP A 164
PHE A 165
 ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
None
 0.55A 3bbtD-6ao5A:
24.0		 3bbtD-6ao5A:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 7 VAL A  27
ALA A  40
LYS A  42
GLY A 100
LEU A 148
THR A 158
PHE A 160
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
CJJ  A 301 (-4.2A)
CJJ  A 301 (-4.5A)
CJJ  A 301 (-3.1A)
None
 1.30A 3bbtD-6b2qA:
23.8		 3bbtD-6b2qA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 7 VAL A 226
ALA A 237
LEU A 286
GLY A 294
LEU A 347
ASP A 358
PHE A 359
 None
DL1  A 601 (-3.4A)
None
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
None
 0.86A 3bbtD-6bfnA:
23.4		 3bbtD-6bfnA:
17.75