SIMILAR PATTERNS OF AMINO ACIDS FOR 3B9L_A_AZZA1010

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ava BARLEY
ALPHA-AMYLASE/SUBTIL
ISIN INHIBITOR

(Hordeum vulgare) 		PF00197
(Kunitz_legume) 		5 LEU C 102
HIS C 108
PHE C 163
GLY C 159
LYS C 158
 None
 1.43A 3b9lA-1avaC:
undetectable		 3b9lA-1avaC:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 142
ILE A 185
HIS A 181
ARG A 149
 None
 0.92A 3b9lA-1bkhA:
0.0		 3b9lA-1bkhA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9k ADENOSYLCOBINAMIDE
KINASE

(Salmonella
enterica) 		PF02283
(CobU) 		4 LEU A 118
ILE A  82
ARG A 160
GLY A 155
 None
 0.78A 3b9lA-1c9kA:
1.4		 3b9lA-1c9kA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		4 LEU A  36
PHE A 228
ARG A  38
GLY A 168
 None
None
HEM  A 350 (-4.1A)
HEM  A 350 ( 4.3A)
 0.95A 3b9lA-1fhfA:
0.8		 3b9lA-1fhfA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 LEU A 305
ILE A  62
GLY A  89
LYS A  88
 None
 0.90A 3b9lA-1jftA:
0.0		 3b9lA-1jftA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 LEU A 305
ILE A  62
GLY A  89
LYS A  88
 None
 0.92A 3b9lA-1jhzA:
0.0		 3b9lA-1jhzA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcf HYPOTHETICAL 30.2 KD
PROTEIN C25G10.02 IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		PF09159
(Ydc2-catalyt) 		4 LEU A   9
ILE A  31
ARG A  20
GLY A  17
 None
 0.89A 3b9lA-1kcfA:
0.0		 3b9lA-1kcfA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 212
ILE A 143
PHE A 240
ARG A 220
 None
 0.75A 3b9lA-1m53A:
0.0		 3b9lA-1m53A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aeropyrum
pernix) 		PF01791
(DeoC) 		4 LEU A 141
ILE A 140
PHE A  81
GLY A 171
 None
 0.88A 3b9lA-1n7kA:
undetectable		 3b9lA-1n7kA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		4 LEU A 465
TYR A 365
ARG A 437
GLY A 420
 None
 0.93A 3b9lA-1qguA:
0.0		 3b9lA-1qguA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1n FERRIC-IRON BINDING
PROTEIN

(Neisseria
gonorrhoeae) 		PF01547
(SBP_bac_1) 		4 LEU A 283
ILE A 280
TYR A 227
GLY A  84
 None
 0.96A 3b9lA-1r1nA:
undetectable		 3b9lA-1r1nA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR

(Saccharomyces
cerevisiae) 		PF04137
(ERO1) 		4 ILE A 199
ARG A 356
GLY A 359
LYS A 360
 FAD  A 634 (-3.7A)
None
FAD  A 634 ( 4.6A)
None
 0.88A 3b9lA-1rq1A:
0.9		 3b9lA-1rq1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A 378
ILE A 280
TYR A 211
GLY A 134
 None
 0.90A 3b9lA-1t34A:
undetectable		 3b9lA-1t34A:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 115
HIS A 146
PHE A 149
GLY A 189
LYS A 190
 None
 0.80A 3b9lA-1tf0A:
37.7		 3b9lA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		4 LEU A  96
ILE A 196
ARG A  44
GLY A  42
 None
None
ZN  A1402 ( 4.7A)
None
 0.97A 3b9lA-1v8dA:
undetectable		 3b9lA-1v8dA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 LEU A 201
ILE A 231
ARG A 239
GLY A 236
 None
None
None
FMT  A 609 ( 4.7A)
 0.90A 3b9lA-1vp4A:
undetectable		 3b9lA-1vp4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 LEU A 131
ILE A 179
GLY A 189
LYS A 188
 None
 0.97A 3b9lA-1w8dA:
undetectable		 3b9lA-1w8dA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl7 ARABINANASE-TS

(Geobacillus
thermodenitrificans) 		PF04616
(Glyco_hydro_43) 		4 LEU A 171
ILE A 205
PHE A 215
GLY A 234
 None
 0.97A 3b9lA-1wl7A:
undetectable		 3b9lA-1wl7A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		4 LEU A1363
PHE A1321
ARG A1374
GLY A1313
 None
 0.82A 3b9lA-1xv5A:
undetectable		 3b9lA-1xv5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 ILE A 667
HIS A 631
PHE A 634
ARG A 624
 None
None
HEM  A 901 ( 4.7A)
PGR  A 805 (-4.2A)
 0.93A 3b9lA-1yiqA:
2.1		 3b9lA-1yiqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN

(Homo sapiens) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU A 192
ILE A 141
HIS A 139
ARG A 194
GLY A 148
 None
 1.16A 3b9lA-1z5vA:
undetectable		 3b9lA-1z5vA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ash QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Thermotoga
maritima) 		PF01702
(TGT) 		4 LEU A 212
ILE A 209
ARG A 255
GLY A 256
 None
 0.89A 3b9lA-2ashA:
undetectable		 3b9lA-2ashA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 221
ILE A 283
HIS A 140
ARG A 280
 None
 0.97A 3b9lA-2bujA:
undetectable		 3b9lA-2bujA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00218
(IGPS) 		4 LEU A 145
ILE A 119
ARG A 150
GLY A 153
 None
 0.91A 3b9lA-2c3zA:
undetectable		 3b9lA-2c3zA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh0 KINESIN-LIKE PROTEIN
KIF1B

(Homo sapiens) 		PF00498
(FHA)
PF16183
(Kinesin_assoc) 		4 LEU A  74
ILE A 101
ARG A  96
GLY A  98
 None
 0.94A 3b9lA-2eh0A:
undetectable		 3b9lA-2eh0A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 LEU A 110
ILE A 334
PHE A 337
GLY A 122
 None
 0.95A 3b9lA-2hzkA:
undetectable		 3b9lA-2hzkA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A  95
ILE A 136
HIS A 139
GLY A 102
 None
 0.95A 3b9lA-2ix5A:
2.0		 3b9lA-2ix5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A  95
ILE A 136
HIS A 139
GLY A 103
 None
 0.94A 3b9lA-2ix5A:
2.0		 3b9lA-2ix5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 LEU A  23
ILE A   3
HIS A  71
GLY A  99
 None
None
None
ONL  A1609 (-3.5A)
 0.95A 3b9lA-2j6hA:
2.2		 3b9lA-2j6hA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 LEU A 498
ILE A 123
ARG A 504
GLY A 506
 None
 0.88A 3b9lA-2jirA:
undetectable		 3b9lA-2jirA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jtc STREPTOPAIN

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10) 		4 LEU A   8
ILE A  55
HIS A  59
GLY A 250
 None
 0.98A 3b9lA-2jtcA:
undetectable		 3b9lA-2jtcA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpu KMATG10

(Kluyveromyces
marxianus) 		PF03987
(Autophagy_act_C) 		4 LEU A  17
ILE A 134
ARG A  15
GLY A  33
 None
 0.91A 3b9lA-2lpuA:
undetectable		 3b9lA-2lpuA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mcn CD2-ASSOCIATED
PROTEIN

(Mus musculus) 		PF14604
(SH3_9) 		4 LEU A  18
ILE A  26
ARG A  21
GLY A  23
 None
 0.84A 3b9lA-2mcnA:
undetectable		 3b9lA-2mcnA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 354
ILE A 322
ARG A 376
GLY A  65
 None
 0.83A 3b9lA-2nqlA:
undetectable		 3b9lA-2nqlA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ny0 ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 LEU A 483
ILE A 251
HIS A 249
GLY A 263
 None
 0.75A 3b9lA-2ny0A:
undetectable		 3b9lA-2ny0A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 LEU A 171
ILE A 102
PHE A 199
ARG A 179
 None
 0.82A 3b9lA-2pwhA:
undetectable		 3b9lA-2pwhA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		4 ILE A 442
TYR A 315
ARG A 227
GLY A 229
 None
 0.95A 3b9lA-2pyjA:
undetectable		 3b9lA-2pyjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rem DISULFIDE
OXIDOREDUCTASE

(Xylella
fastidiosa) 		PF13462
(Thioredoxin_4) 		4 ILE A  99
HIS A 100
PHE A  96
GLY A  35
 None
 0.81A 3b9lA-2remA:
undetectable		 3b9lA-2remA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rir DIPICOLINATE
SYNTHASE, A CHAIN

(Bacillus
subtilis) 		PF01262
(AlaDh_PNT_C)
PF16924
(DpaA_N) 		4 LEU A  85
ILE A  10
PHE A  35
GLY A  12
 None
 0.93A 3b9lA-2rirA:
undetectable		 3b9lA-2rirA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxy ALIPHATIC AMIDASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		5 LEU A 258
ILE A 235
TYR A 255
ARG A   2
GLY A   4
 None
 1.48A 3b9lA-2uxyA:
undetectable		 3b9lA-2uxyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uye REGULATORY PROTEIN

(Burkholderia
cepacia) 		PF03466
(LysR_substrate) 		4 LEU A 151
ILE A 273
HIS A 169
GLY A 205
 None
SCN  A1303 (-4.1A)
SCN  A1303 (-4.4A)
SCN  A1307 (-3.5A)
 0.96A 3b9lA-2uyeA:
undetectable		 3b9lA-2uyeA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 220
ILE A 304
ARG A 345
GLY A 347
 None
 0.80A 3b9lA-2v7bA:
undetectable		 3b9lA-2v7bA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		4 ILE A 123
HIS A 304
PHE A 301
TYR A  91
 None
 0.96A 3b9lA-2vatA:
undetectable		 3b9lA-2vatA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 183
HIS A 187
ARG A 324
GLY A 326
 None
 0.91A 3b9lA-2vd5A:
undetectable		 3b9lA-2vd5A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU C 182
ILE C 177
HIS C 174
GLY C 215
 None
 0.89A 3b9lA-2wtkC:
undetectable		 3b9lA-2wtkC:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		4 LEU A 182
ILE A 188
ARG A 213
GLY A 209
 None
 0.87A 3b9lA-2xsbA:
2.6		 3b9lA-2xsbA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz4 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN LF

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 LEU A 199
ILE A  85
HIS A  87
GLY A 142
 None
None
EDO  A 601 (-3.9A)
None
 0.82A 3b9lA-2xz4A:
undetectable		 3b9lA-2xz4A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 LEU A 298
ILE A  75
TYR A  68
GLY A  48
 None
 0.94A 3b9lA-2y24A:
undetectable		 3b9lA-2y24A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		4 LEU A 843
ILE A 840
ARG A 846
GLY A 774
 None
 0.94A 3b9lA-2yn9A:
2.6		 3b9lA-2yn9A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		4 ILE A 234
TYR A  47
ARG A 230
GLY A 225
 None
 0.82A 3b9lA-2z55A:
1.7		 3b9lA-2z55A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		4 LEU A 113
ILE A  28
ARG A 118
GLY A 121
 None
 0.90A 3b9lA-3allA:
undetectable		 3b9lA-3allA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bac DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		4 LEU A 169
ILE A 252
ARG A 172
GLY A 173
 None
None
3B9  A 501 ( 4.8A)
None
 0.95A 3b9lA-3bacA:
undetectable		 3b9lA-3bacA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbh RIBOSOME BIOGENESIS
PROTEIN NEP1-LIKE

(Methanocaldococcus
jannaschii) 		PF03587
(EMG1) 		4 LEU A  12
ILE A  33
TYR A 100
ARG A  54
 None
 0.96A 3b9lA-3bbhA:
undetectable		 3b9lA-3bbhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxp PUTATIVE
LIPASE/ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 ILE A 150
HIS A 147
TYR A 212
GLY A 127
 None
 0.85A 3b9lA-3bxpA:
undetectable		 3b9lA-3bxpA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0c ENDOPHILIN-A2

(Rattus
norvegicus) 		PF00018
(SH3_1) 		4 LEU A 325
ILE A 333
ARG A 328
GLY A 330
 None
 0.94A 3b9lA-3c0cA:
undetectable		 3b9lA-3c0cA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8w ACETOACETATE
DECARBOXYLASE ADC

(Legionella
pneumophila) 		PF06314
(ADC) 		4 LEU A 127
PHE A  81
ARG A 118
GLY A 116
 None
LCK  A 125 ( 4.4A)
LCK  A 125 (-3.9A)
None
 0.89A 3b9lA-3c8wA:
undetectable		 3b9lA-3c8wA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctk RRNA N-GLYCOSIDASE

(Bougainvillea
spectabilis) 		PF00161
(RIP) 		4 LEU A  34
ILE A 205
HIS A 206
GLY A 199
 None
 0.91A 3b9lA-3ctkA:
undetectable		 3b9lA-3ctkA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		4 LEU A 159
ILE A  49
HIS A 153
GLY A 194
 None
 0.96A 3b9lA-3czpA:
undetectable		 3b9lA-3czpA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddd PUTATIVE
ACETYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		4 LEU A  93
ILE A  70
PHE A  62
GLY A  45
 None
 0.92A 3b9lA-3dddA:
undetectable		 3b9lA-3dddA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1b TETR-LIKE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 187
ILE A 155
PHE A 152
ARG A 190
 None
 0.90A 3b9lA-3f1bA:
3.9		 3b9lA-3f1bA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A  20
ILE A 144
PHE A 148
GLY A 173
 None
 0.94A 3b9lA-3fd5A:
undetectable		 3b9lA-3fd5A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 332
ILE A 284
HIS A 214
GLY A 216
 None
 0.91A 3b9lA-3fs1A:
undetectable		 3b9lA-3fs1A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 LEU A 185
ILE A 116
PHE A 213
ARG A 193
 None
 0.76A 3b9lA-3gbdA:
undetectable		 3b9lA-3gbdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 450
ILE A   5
ARG A  22
GLY A  24
 None
 0.96A 3b9lA-3hz6A:
undetectable		 3b9lA-3hz6A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j70 ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 LEU D 483
ILE D 251
HIS D 249
GLY D 263
 None
 0.87A 3b9lA-3j70D:
undetectable		 3b9lA-3j70D:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq3 LOMBRICINE KINASE

(Urechis caupo) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 LEU A 213
ILE A 214
ARG A 239
GLY A 243
 None
 0.95A 3b9lA-3jq3A:
undetectable		 3b9lA-3jq3A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN

(Homo sapiens) 		PF00516
(GP120) 		4 LEU A 483
ILE A 251
HIS A 249
GLY A 263
 None
 0.62A 3b9lA-3jwoA:
undetectable		 3b9lA-3jwoA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3n PHD FINGER PROTEIN 8

(Homo sapiens) 		PF02373
(JmjC) 		4 LEU A 276
ILE A 318
PHE A 246
GLY A 294
 None
 0.88A 3b9lA-3k3nA:
2.2		 3b9lA-3k3nA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kre PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Ehrlichia
chaffeensis) 		PF01259
(SAICAR_synt) 		4 LEU A 148
ILE A 151
GLY A 181
LYS A 182
 None
 0.90A 3b9lA-3kreA:
undetectable		 3b9lA-3kreA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 LEU A 276
ILE A 318
PHE A 246
GLY A 294
 None
 0.91A 3b9lA-3kv4A:
3.1		 3b9lA-3kv4A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv6 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1D

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		5 LEU A 311
ILE A 353
PHE A 281
ARG A 313
GLY A 329
 None
 0.98A 3b9lA-3kv6A:
undetectable		 3b9lA-3kv6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqa ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 LEU G 485
ILE G 247
HIS G 245
GLY G 259
 None
 0.72A 3b9lA-3lqaG:
undetectable		 3b9lA-3lqaG:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 1

(Mycolicibacterium
smegmatis) 		PF02682
(CT_C_D) 		4 LEU B 161
PHE B 128
ARG B 147
GLY B 175
 None
 0.81A 3b9lA-3mmlB:
undetectable		 3b9lA-3mmlB:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 188
HIS A 192
ARG A 327
GLY A 329
 None
 0.90A 3b9lA-3qfvA:
undetectable		 3b9lA-3qfvA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		4 LEU A 390
ILE A 534
TYR A 475
GLY A 608
 None
 0.71A 3b9lA-3rdeA:
undetectable		 3b9lA-3rdeA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE

(Scaptodrosophila
lebanonensis) 		PF00106
(adh_short) 		4 LEU A  45
ILE A  35
PHE A  10
GLY A  18
 None
 0.83A 3b9lA-3rj9A:
undetectable		 3b9lA-3rj9A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 1
SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF)
PF12026
(DUF3513) 		4 LEU A 623
ILE B 786
ARG B 824
GLY B 825
 None
 0.94A 3b9lA-3t6gA:
undetectable		 3b9lA-3t6gA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		4 LEU A 119
ILE A 171
TYR A 327
GLY A 163
 None
 0.96A 3b9lA-3tc8A:
undetectable		 3b9lA-3tc8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgq HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 LEU A 483
ILE A 251
HIS A 249
GLY A 263
 None
 0.72A 3b9lA-3tgqA:
undetectable		 3b9lA-3tgqA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tih HIV-1 CLADE C
ZM109F.PB4 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 LEU A 483
ILE A 251
HIS A 249
GLY A 263
 None
 0.66A 3b9lA-3tihA:
undetectable		 3b9lA-3tihA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u78 LYSINE-SPECIFIC
DEMETHYLASE 7

(Homo sapiens) 		PF02373
(JmjC) 		5 LEU A 311
ILE A 353
PHE A 281
ARG A 313
GLY A 329
 None
None
None
SO4  A 704 (-4.0A)
None
 1.02A 3b9lA-3u78A:
2.8		 3b9lA-3u78A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 ILE A 737
HIS A 487
TYR A 465
GLY A 510
 None
FE  A 807 ( 3.4A)
None
AP2  A 806 ( 4.8A)
 0.93A 3b9lA-3vthA:
undetectable		 3b9lA-3vthA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfj 2-DEHYDROPANTOATE
2-REDUCTASE

(Enterococcus
faecium) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 LEU A 103
ILE A  75
ARG A  14
GLY A  16
 None
 0.94A 3b9lA-3wfjA:
2.3		 3b9lA-3wfjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x17 ENDOGLUCANASE

(uncultured
bacterium) 		no annotation 4 LEU B 147
ILE B 154
HIS B 163
GLY B 151
 None
 0.78A 3b9lA-3x17B:
undetectable		 3b9lA-3x17B:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		4 LEU A 764
ILE A 781
PHE A 742
ARG A 804
 None
 0.95A 3b9lA-4a0hA:
2.8		 3b9lA-4a0hA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a29 ENGINEERED
RETRO-ALDOL ENZYME
RA95.0

(synthetic
construct) 		PF00218
(IGPS) 		4 LEU A 145
ILE A 119
ARG A 150
GLY A 153
 None
 0.93A 3b9lA-4a29A:
undetectable		 3b9lA-4a29A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ILE A 189
HIS A 193
ARG A 328
GLY A 330
 None
 0.89A 3b9lA-4aw2A:
undetectable		 3b9lA-4aw2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		4 LEU A 338
ILE A 283
TYR A 302
GLY A 328
 None
 0.96A 3b9lA-4aweA:
undetectable		 3b9lA-4aweA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 LEU A1288
ILE A1250
ARG A1354
GLY A1363
 None
None
GOL  A2775 (-3.8A)
None
 0.94A 3b9lA-4aygA:
undetectable		 3b9lA-4aygA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 LEU A 292
ILE A 251
HIS A 252
GLY A 284
 None
 0.93A 3b9lA-4b8jA:
undetectable		 3b9lA-4b8jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		4 LEU A 292
ILE A 251
HIS A 252
GLY A 284
 None
 0.96A 3b9lA-4bplA:
undetectable		 3b9lA-4bplA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		4 LEU A 458
ILE A 524
ARG A 463
GLY A 466
 None
 0.94A 3b9lA-4c51A:
2.3		 3b9lA-4c51A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		4 LEU A 678
ILE A 675
HIS A 671
GLY A 692
 None
 0.92A 3b9lA-4ci8A:
undetectable		 3b9lA-4ci8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans) 		PF10275
(Peptidase_C65) 		4 ILE B 100
PHE B 111
ARG B 228
GLY B 226
 None
 0.95A 3b9lA-4dhiB:
2.3		 3b9lA-4dhiB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		4 LEU A 103
ILE A 162
HIS A 160
TYR A 195
 None
None
None
1PE  A 500 (-4.7A)
 0.95A 3b9lA-4dn7A:
2.9		 3b9lA-4dn7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 LEU A 328
ILE A 265
HIS A 219
GLY A 443
 None
 0.96A 3b9lA-4f0xA:
undetectable		 3b9lA-4f0xA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 LEU A 966
ILE A 995
ARG A 979
GLY A 988
 None
 0.86A 3b9lA-4hpfA:
undetectable		 3b9lA-4hpfA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 LEU A 332
ILE A 284
HIS A 214
GLY A 216
 None
 0.92A 3b9lA-4iqrA:
undetectable		 3b9lA-4iqrA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jm2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 LEU E 483
ILE E 251
HIS E 249
GLY E 263
 None
 0.81A 3b9lA-4jm2E:
undetectable		 3b9lA-4jm2E:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 LEU A 167
HIS A 608
TYR A 547
GLY A 553
 None
 0.97A 3b9lA-4jzaA:
3.3		 3b9lA-4jzaA:
22.42