SIMILAR PATTERNS OF AMINO ACIDS FOR 3B9L_A_AZZA1009_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5) 		4 GLU A 161
VAL A 209
CYH A 187
ARG A 189
 None
 1.19A 3b9lA-1b7eA:
3.6		 3b9lA-1b7eA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 TYR A 102
GLU A 103
SER A   2
VAL A  36
 None
 1.26A 3b9lA-1c4kA:
0.0		 3b9lA-1c4kA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN

(Thermococcus
litoralis) 		PF01547
(SBP_bac_1) 		4 TYR A 177
GLU A 178
SER A 374
GLN A 378
 TRE  A 563 (-4.7A)
None
None
None
 0.82A 3b9lA-1eu8A:
0.4		 3b9lA-1eu8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 TYR A 255
SER A 251
HIS A 214
ARG A 243
 None
FEL  A 500 ( 4.3A)
FEL  A 500 (-3.3A)
None
 1.04A 3b9lA-1f1xA:
0.0		 3b9lA-1f1xA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f20 NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 TYR A1347
SER A1258
VAL A1242
CYH A1244
 None
 1.17A 3b9lA-1f20A:
0.0		 3b9lA-1f20A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7u ARGINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 GLU A 132
GLN A 590
HIS A 493
ARG A 597
 None
 1.24A 3b9lA-1f7uA:
1.6		 3b9lA-1f7uA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 GLU A 249
SER A 374
VAL A 403
HIS A 406
 None
 1.15A 3b9lA-1gzkA:
0.9		 3b9lA-1gzkA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		4 SER A  87
GLN A 197
VAL A  23
CYH A 218
 None
TYE  A1434 ( 3.5A)
None
None
 1.20A 3b9lA-1h3eA:
0.0		 3b9lA-1h3eA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hc7 PROLYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 TYR A  42
GLU A  26
VAL A 291
HIS A 323
 None
 1.22A 3b9lA-1hc7A:
0.1		 3b9lA-1hc7A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcl CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 TYR A 388
SER A 380
GLN A 364
VAL A  71
 None
 1.19A 3b9lA-1kclA:
undetectable		 3b9lA-1kclA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 TYR B 394
SER B 391
VAL B  55
HIS B  59
 None
 1.22A 3b9lA-1mioB:
undetectable		 3b9lA-1mioB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		4 SER A 196
GLN A 176
VAL A 128
CYH A 171
 None
 1.01A 3b9lA-1nmoA:
undetectable		 3b9lA-1nmoA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmp P2 MYELIN PROTEIN

(Bos taurus) 		PF00061
(Lipocalin) 		4 GLU A  72
SER A  82
GLN A  93
CYH A 117
 None
None
None
OLA  A 200 ( 4.4A)
 1.17A 3b9lA-1pmpA:
undetectable		 3b9lA-1pmpA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		4 GLU A  29
GLN A 351
CYH A 348
ARG A  69
 GOL  A 503 ( 4.7A)
GOL  A 503 (-3.9A)
None
None
 0.96A 3b9lA-1pz3A:
undetectable		 3b9lA-1pz3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 GLU A 626
GLN A 665
VAL A 705
HIS A 706
 None
 1.18A 3b9lA-1qgrA:
2.6		 3b9lA-1qgrA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr7 PHENYLALANINE-REGULA
TED
3-DEOXY-D-ARABINO-HE
PTULOSONATE-7-PHOSPH
ATE SYNTHASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		4 SER A 271
GLN A 278
VAL A  57
ARG A  92
 None
None
None
PEP  A1352 (-3.2A)
 1.10A 3b9lA-1qr7A:
undetectable		 3b9lA-1qr7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5t CYTIDINE DEAMINASE

(Saccharomyces
cerevisiae) 		PF00383
(dCMP_cyt_deam_1) 		4 GLU A  52
SER A  30
VAL A  98
CYH A  96
 None
None
None
ZN  A 150 (-2.2A)
 1.20A 3b9lA-1r5tA:
undetectable		 3b9lA-1r5tA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 TYR A 613
SER A 607
VAL A 817
CYH A 616
 None
 1.18A 3b9lA-1vrqA:
undetectable		 3b9lA-1vrqA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we0 ALKYL HYDROPEROXIDE
REDUCTASE C

(Amphibacillus
xylanus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 TYR A  94
GLN A  16
VAL A  89
HIS A  83
 None
 1.17A 3b9lA-1we0A:
undetectable		 3b9lA-1we0A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		5 GLU A 401
SER A 428
GLN A 403
VAL A 236
HIS A 237
 None
 1.38A 3b9lA-1xdpA:
3.0		 3b9lA-1xdpA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdw NAD+-DEPENDENT
(R)-2-HYDROXYGLUTARA
TE DEHYDROGENASE

(Acidaminococcus
fermentans) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 SER A 313
HIS A  82
CYH A  55
ARG A  52
 None
 1.18A 3b9lA-1xdwA:
undetectable		 3b9lA-1xdwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		4 GLU A 101
SER A 146
GLN A 152
VAL A  94
 None
 1.19A 3b9lA-2a9vA:
undetectable		 3b9lA-2a9vA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		4 TYR A 747
GLU A 751
VAL A 744
ARG A 745
 None
 0.98A 3b9lA-2aqxA:
undetectable		 3b9lA-2aqxA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 GLU A 431
SER A 222
VAL A  63
CYH A  93
 None
 1.24A 3b9lA-2bf4A:
undetectable		 3b9lA-2bf4A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bop PROTEIN (E2)

(Deltapapillomavirus
4) 		PF00511
(PPV_E2_C) 		4 TYR A 353
GLU A 354
GLN A 385
ARG A 350
 None
 1.11A 3b9lA-2bopA:
undetectable		 3b9lA-2bopA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLU A 135
SER A 313
VAL A 201
CYH A 235
 None
 1.21A 3b9lA-2hjsA:
undetectable		 3b9lA-2hjsA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqj PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Leishmania
major) 		PF00160
(Pro_isomerase) 		4 TYR A  25
SER A  94
HIS A 102
CYH A 107
 None
 1.25A 3b9lA-2hqjA:
undetectable		 3b9lA-2hqjA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krn CD2-ASSOCIATED
PROTEIN

(Mus musculus) 		PF14604
(SH3_9) 		4 GLU A  33
SER A   2
VAL A  56
CYH A   7
 None
 0.93A 3b9lA-2krnA:
undetectable		 3b9lA-2krnA:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lzu LIM
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00412
(LIM) 		4 TYR A 105
GLU A 107
GLN A  96
CYH A  91
 None
None
None
ZN  A 202 (-2.3A)
 1.20A 3b9lA-2lzuA:
undetectable		 3b9lA-2lzuA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m0u NA(+)/H(+) EXCHANGE
REGULATORY COFACTOR
NHE-RF1

(Homo sapiens) 		PF00595
(PDZ) 		4 TYR A  38
GLN A  37
VAL A  91
ARG A  58
 None
 1.26A 3b9lA-2m0uA:
undetectable		 3b9lA-2m0uA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 GLU A  62
SER A  29
GLN A  30
VAL A 195
 None
 1.18A 3b9lA-2nlzA:
undetectable		 3b9lA-2nlzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2orz NEUROPILIN-1

(Rattus
norvegicus) 		PF00754
(F5_F8_type_C) 		4 TYR A 480
GLU A 483
SER A 450
VAL A 510
 None
 1.12A 3b9lA-2orzA:
undetectable		 3b9lA-2orzA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozk URIDYLATE-SPECIFIC
ENDORIBONUCLEASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		4 GLU A  68
SER A 197
GLN A 159
VAL A 172
 None
 0.74A 3b9lA-2ozkA:
undetectable		 3b9lA-2ozkA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9s FATTY ACID-BINDING
PROTEIN

(Mus musculus) 		PF00061
(Lipocalin) 		4 GLU A  72
SER A  82
GLN A  93
CYH A 117
 None
None
None
EIC  A 601 (-3.3A)
 1.18A 3b9lA-2q9sA:
undetectable		 3b9lA-2q9sA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqm NEUROPILIN-1

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 TYR A 480
GLU A 483
SER A 450
VAL A 510
 None
 1.13A 3b9lA-2qqmA:
undetectable		 3b9lA-2qqmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 GLU A 513
SER A 649
VAL A 673
HIS A 676
 None
 1.26A 3b9lA-2qr7A:
undetectable		 3b9lA-2qr7A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v65 L-LACTATE
DEHYDROGENASE A
CHAIN

(Champsocephalus
gunnari) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLU A 194
SER A 318
VAL A 232
HIS A 229
 None
 1.24A 3b9lA-2v65A:
undetectable		 3b9lA-2v65A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		4 TYR A 410
SER A 393
GLN A 414
VAL A 503
 AS5  A1551 (-4.6A)
None
None
None
 1.25A 3b9lA-2vlcA:
undetectable		 3b9lA-2vlcA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 GLN A 261
VAL A 129
HIS A 137
ARG A 107
 None
 1.25A 3b9lA-2wk2A:
undetectable		 3b9lA-2wk2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		4 GLU A  21
SER A 320
GLN A 341
VAL A 375
 None
 1.23A 3b9lA-2wu0A:
undetectable		 3b9lA-2wu0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yf0 MYOTUBULARIN-RELATED
PROTEIN 6

(Homo sapiens) 		PF06602
(Myotub-related) 		4 GLU A  57
SER A  55
GLN A  71
VAL A  12
 None
 0.93A 3b9lA-2yf0A:
undetectable		 3b9lA-2yf0A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z23 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 TYR A 112
SER A 434
VAL A 152
HIS A 117
 None
 1.17A 3b9lA-2z23A:
2.0		 3b9lA-2z23A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5b UNCHARACTERIZED
PROTEIN YLR021W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		4 GLU B  26
GLN B   7
VAL B 169
CYH B 172
 None
 1.26A 3b9lA-2z5bB:
undetectable		 3b9lA-2z5bB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5e PROTEASOME
ASSEMBLING CHAPERONE
3

(Homo sapiens) 		PF10178
(PAC3) 		4 GLU A  89
GLN A 120
VAL A  23
CYH A  25
 None
 1.11A 3b9lA-2z5eA:
undetectable		 3b9lA-2z5eA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am3 ENOYL-ACP REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 GLU A 289
SER A 270
GLN A 271
ARG A 293
 None
 1.26A 3b9lA-3am3A:
undetectable		 3b9lA-3am3A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bmw CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Thermoanaerobacterium
thermosulfurigenes) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 TYR A 388
SER A 380
GLN A 364
VAL A  71
 None
 1.21A 3b9lA-3bmwA:
undetectable		 3b9lA-3bmwA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dev SH1221

(Staphylococcus
haemolyticus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 GLU A 302
GLN A 220
VAL A 293
CYH A 266
 None
 0.84A 3b9lA-3devA:
undetectable		 3b9lA-3devA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		4 TYR A 255
SER A 251
HIS A 214
ARG A 243
 None
None
FE2  A 500 (-3.4A)
CL  A 501 (-3.0A)
 1.13A 3b9lA-3eckA:
undetectable		 3b9lA-3eckA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11)
PF14710
(Nitr_red_alph_N)
PF14711
(Nitr_red_bet_C) 		4 TYR A  77
VAL B 264
HIS A 265
ARG A  90
 None
F3S  B 802 (-4.9A)
None
None
 1.17A 3b9lA-3egwA:
undetectable		 3b9lA-3egwA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 GLU A 155
SER A 360
GLN A 364
VAL A 388
 ADN  A 438 (-3.8A)
ADN  A 438 ( 4.6A)
None
None
 1.12A 3b9lA-3g1uA:
undetectable		 3b9lA-3g1uA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 200
GLU A 192
SER A 293
HIS A 142
 None
 1.13A 3b9lA-3gp0A:
undetectable		 3b9lA-3gp0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7n PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF00117
(GATase) 		4 GLU A 112
SER A 159
GLN A 165
CYH A  91
 None
 1.13A 3b9lA-3l7nA:
undetectable		 3b9lA-3l7nA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 GLU A 109
SER A 237
VAL A 146
CYH A 157
 None
 1.14A 3b9lA-3l7zA:
undetectable		 3b9lA-3l7zA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 TYR A 237
GLU A 231
SER A 303
HIS A 176
 None
 1.10A 3b9lA-3lijA:
undetectable		 3b9lA-3lijA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 GLU A 820
SER A 776
GLN A 780
HIS A 725
 None
 1.09A 3b9lA-3lj0A:
undetectable		 3b9lA-3lj0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		4 GLU A 110
SER A 156
GLN A 162
CYH A  89
 None
 1.16A 3b9lA-3m3pA:
undetectable		 3b9lA-3m3pA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		4 GLU A 110
SER A 156
GLN A 162
VAL A 103
 None
 1.07A 3b9lA-3m3pA:
undetectable		 3b9lA-3m3pA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt0 UNCHARACTERIZED
PROTEIN PA1789

(Pseudomonas
aeruginosa) 		PF00582
(Usp) 		4 GLU A 281
SER A 285
GLN A  83
VAL A 120
 None
 1.27A 3b9lA-3mt0A:
undetectable		 3b9lA-3mt0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 GLU A  55
SER A  45
VAL A 314
HIS A 415
 None
None
None
FAD  A 479 ( 4.9A)
 1.01A 3b9lA-3nksA:
undetectable		 3b9lA-3nksA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntu DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Methanococcus
voltae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 GLU A 151
SER A 215
GLN A 257
VAL A 288
 ANP  A 401 (-4.0A)
None
None
None
 1.05A 3b9lA-3ntuA:
undetectable		 3b9lA-3ntuA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 GLN A   6
VAL A  52
CYH A  54
ARG A 185
 None
 1.00A 3b9lA-3qkaA:
undetectable		 3b9lA-3qkaA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE

(Bacteroides
fragilis) 		PF10282
(Lactonase) 		4 TYR A 140
GLU A  92
SER A  76
HIS A 238
 UNL  A 385 ( 3.7A)
UNL  A 385 ( 2.8A)
None
None
 1.26A 3b9lA-3scyA:
undetectable		 3b9lA-3scyA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 GLU A 402
VAL A 431
HIS A 435
ARG A 426
 None
 1.17A 3b9lA-3slkA:
undetectable		 3b9lA-3slkA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Francisella
tularensis) 		PF00793
(DAHP_synth_1) 		4 SER A 277
GLN A 284
VAL A  62
ARG A  97
 None
None
None
ACT  A1002 (-4.2A)
 1.18A 3b9lA-3tqkA:
undetectable		 3b9lA-3tqkA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tz6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLU A 110
SER A 109
GLN A 336
VAL A 297
 GOL  A 404 ( 4.1A)
GOL  A 404 (-2.7A)
GOL  A 404 (-3.7A)
None
 1.26A 3b9lA-3tz6A:
undetectable		 3b9lA-3tz6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnw FERRITIN HEAVY CHAIN

(Mus musculus) 		PF00210
(Ferritin) 		4 TYR A 137
GLU A 140
SER A 144
GLN A 141
 None
None
None
MG  A 201 (-4.1A)
 1.22A 3b9lA-3wnwA:
undetectable		 3b9lA-3wnwA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp9 ICE-BINDING PROTEIN

(Colwellia sp.
SLW05) 		PF11999
(DUF3494) 		4 TYR A   4
GLU A   7
VAL A 113
ARG A  91
 None
 1.23A 3b9lA-3wp9A:
undetectable		 3b9lA-3wp9A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4beg PHOSPHATIDYLETHANOLA
MINE BINDING PROTEIN

(Mycobacterium
tuberculosis) 		PF01161
(PBP) 		4 TYR A 133
VAL A 129
HIS A 130
ARG A 131
 None
 1.24A 3b9lA-4begA:
undetectable		 3b9lA-4begA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 GLU A 225
SER A 177
HIS A 133
ARG A 115
 ZMR  A 700 (-3.5A)
ZMR  A 700 ( 4.6A)
None
ZMR  A 700 (-2.9A)
 1.18A 3b9lA-4cpnA:
undetectable		 3b9lA-4cpnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvh ISOPRENOID SYNTHASE
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF01128
(IspD) 		4 GLU A 239
SER A 211
GLN A 215
VAL A 221
 None
 1.06A 3b9lA-4cvhA:
undetectable		 3b9lA-4cvhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 TYR A 154
SER A 141
VAL A 162
HIS A 161
 None
 1.18A 3b9lA-4dxyA:
1.9		 3b9lA-4dxyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 TYR A 260
VAL A 272
CYH A 236
ARG A 264
 None
 1.00A 3b9lA-4fddA:
undetectable		 3b9lA-4fddA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs4 ALPHA-TUBULIN
N-ACETYLTRANSFERASE

(Homo sapiens) 		PF05301
(Acetyltransf_16) 		4 TYR A 101
GLU A 117
VAL A  76
HIS A  75
 None
 1.22A 3b9lA-4gs4A:
undetectable		 3b9lA-4gs4A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4if5 ALPHA-TUBULIN
N-ACETYLTRANSFERASE

(Homo sapiens) 		PF05301
(Acetyltransf_16) 		4 TYR A 101
GLU A 117
VAL A  76
HIS A  75
 None
None
None
CL  A 202 (-4.4A)
 1.26A 3b9lA-4if5A:
undetectable		 3b9lA-4if5A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 TYR A 389
SER A 381
GLN A 365
VAL A  71
 None
None
None
GOL  A 715 (-4.9A)
 1.20A 3b9lA-4jclA:
undetectable		 3b9lA-4jclA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 GLU A 704
SER A 605
HIS A 664
ARG A 811
 None
 0.93A 3b9lA-4k0eA:
3.3		 3b9lA-4k0eA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		4 TYR A 259
GLU A 260
SER A 234
VAL A 126
 None
 1.20A 3b9lA-4kv7A:
undetectable		 3b9lA-4kv7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		4 GLU A 181
SER A 514
GLN A 518
VAL A 525
 None
 1.25A 3b9lA-4mk0A:
2.7		 3b9lA-4mk0A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		4 GLU A 193
GLN A  67
VAL A 113
HIS A 115
 None
 1.26A 3b9lA-4muoA:
undetectable		 3b9lA-4muoA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 GLU A  82
SER A  99
HIS A 186
ARG A 179
 EAX  A 401 (-3.0A)
None
None
EAX  A 401 (-3.0A)
 1.26A 3b9lA-4pdhA:
undetectable		 3b9lA-4pdhA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 TYR A 250
GLU A 222
GLN A 248
HIS A  86
 None
None
None
ZN  A 601 (-3.1A)
 0.84A 3b9lA-4xwtA:
3.1		 3b9lA-4xwtA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxf FUCULOSE-1-PHOSPHATE
ALDOLASE

(Glaciozyma
antarctica) 		PF00596
(Aldolase_II) 		4 GLU A 259
SER A 217
HIS A 131
ARG A 134
 None
 0.99A 3b9lA-4xxfA:
undetectable		 3b9lA-4xxfA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ygt UNCHARACTERIZED
PROTEIN YJGB

(Bacillus
subtilis) 		PF14172
(DUF4309) 		4 SER A 120
VAL A 176
HIS A 174
ARG A 123
 None
None
None
SO4  A 201 (-3.6A)
 1.15A 3b9lA-4ygtA:
undetectable		 3b9lA-4ygtA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 GLU A  70
SER A 450
HIS A 535
ARG A 530
 None
 1.12A 3b9lA-4zdkA:
2.2		 3b9lA-4zdkA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 GLU D 145
SER D 142
VAL D  90
CYH D  92
 None
 1.26A 3b9lA-5a6bD:
1.5		 3b9lA-5a6bD:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce7 CTD KINASE SUBUNIT
GAMMA

(Schizosaccharomyces
pombe) 		PF12243
(CTK3) 		4 TYR A  62
SER A  23
GLN A  24
VAL A  95
 EPE  A 202 (-3.9A)
None
None
None
 1.24A 3b9lA-5ce7A:
2.3		 3b9lA-5ce7A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		4 GLU A 187
SER A 377
GLN A 381
VAL A 181
 None
 1.24A 3b9lA-5ci5A:
1.8		 3b9lA-5ci5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		4 TYR A 441
SER A 535
HIS A 608
ARG A 613
 None
 1.21A 3b9lA-5gggA:
undetectable		 3b9lA-5gggA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 SER A 310
GLN A 349
VAL A 416
HIS A 413
 None
 1.15A 3b9lA-5gsmA:
undetectable		 3b9lA-5gsmA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 4 GLU A 672
SER A 658
HIS A 633
CYH A 632
 None
 1.20A 3b9lA-5id6A:
3.7		 3b9lA-5id6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 4 SER A 962
VAL A 908
HIS A 909
CYH A 912
 None
None
G  G  20 ( 4.1A)
None
 1.21A 3b9lA-5id6A:
3.7		 3b9lA-5id6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13407
(Peripla_BP_4) 		4 GLU A 291
SER A 270
VAL A  61
HIS A  63
 None
None
None
EDO  A 503 ( 4.7A)
 1.22A 3b9lA-5ix8A:
undetectable		 3b9lA-5ix8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 GLU A1072
SER A1046
VAL A 643
ARG A1139
 None
 1.21A 3b9lA-5m59A:
3.1		 3b9lA-5m59A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxb CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN

(Lupinus luteus) 		no annotation 4 TYR A  65
SER A  39
VAL A  85
HIS A  68
 None
None
None
ML1  A 220 ( 4.8A)
 0.90A 3b9lA-5mxbA:
undetectable		 3b9lA-5mxbA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 GLU A 587
GLN A 231
VAL A 717
ARG A 709
 None
 1.14A 3b9lA-5ot1A:
undetectable		 3b9lA-5ot1A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3
MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 GLU 5 637
SER 5 645
GLN 3 522
VAL 3 549
 None
 1.12A 3b9lA-5udb5:
2.4		 3b9lA-5udb5:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 GLU A 181
SER A 514
GLN A 518
VAL A 525
 None
 1.23A 3b9lA-5uuuA:
undetectable		 3b9lA-5uuuA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN

(Human
betaherpesvirus
5;
Lama glama) 		no annotation 4 TYR A 131
SER A  67
VAL A 203
CYH A 207
 None
 1.07A 3b9lA-5wb1A:
1.3		 3b9lA-5wb1A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xev XAA-PRO
DIPEPTIDASE,PEPTIDAS
E-RELATED PROTEIN

(Deinococcus
radiodurans) 		no annotation 4 GLU A  89
SER A  86
VAL A  59
ARG A  82
 None
 1.15A 3b9lA-5xevA:
undetectable		 3b9lA-5xevA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn0 -

(-) 		no annotation 4 TYR A 109
GLU A 107
VAL A  38
ARG A 113
 None
 1.26A 3b9lA-6fn0A:
undetectable		 3b9lA-6fn0A:
undetectable