SIMILAR PATTERNS OF AMINO ACIDS FOR 3B7P_B_SPMB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii) 		PF00995
(Sec1) 		5 HIS A 500
ASP A 497
GLU A 489
TYR A 483
ILE A 487
 None
 1.37A 3b7pB-1fvfA:
undetectable		 3b7pB-1fvfA:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 TYR A  76
HIS A  77
ASP A 101
ASP A 170
TYR A 239
PRO A 240
 None
 0.38A 3b7pB-1inlA:
38.1		 3b7pB-1inlA:
37.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLN A 189
HIS A  63
TYR A 224
PRO A 225
ILE A 221
 None
 1.46A 3b7pB-1iy9A:
37.1		 3b7pB-1iy9A:
39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 HIS A  63
ASP A  87
TYR A 224
PRO A 225
ILE A 221
 None
 1.42A 3b7pB-1iy9A:
37.1		 3b7pB-1iy9A:
39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iy9 SPERMIDINE SYNTHASE

(Bacillus
subtilis) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 TYR A  62
HIS A  63
ASP A  87
TYR A 224
PRO A 225
 None
 0.42A 3b7pB-1iy9A:
37.1		 3b7pB-1iy9A:
39.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		8 GLN A  51
TYR A  60
HIS A  61
ASP A  85
ASP A 158
ASP A 161
GLN A 191
TYR A 226
 None
 0.47A 3b7pB-1mjfA:
36.6		 3b7pB-1mjfA:
35.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tye INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 TYR B 289
HIS B 255
ASP B 217
ASP B 158
ILE B 265
 None
None
CA  B1403 ( 2.8A)
CA  B1403 (-3.0A)
None
 1.37A 3b7pB-1tyeB:
undetectable		 3b7pB-1tyeB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wt5 ANTI EGFR ANTIBODY
FV REGION

(Homo sapiens) 		PF07686
(V-set) 		5 GLN C  50
TYR C  91
GLU C  84
PRO C  64
ILE C  80
 None
 1.44A 3b7pB-1wt5C:
undetectable		 3b7pB-1wt5C:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		5 HIS A  81
ASP A 531
GLU A  92
PRO A 122
ILE A  87
 A  C 988 ( 4.1A)
None
None
None
None
 1.46A 3b7pB-1wz2A:
undetectable		 3b7pB-1wz2A:
14.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		9 TRP A  55
GLN A  97
TYR A 106
ASP A 131
ASP A 204
GLN A 234
TYR A 270
PRO A 271
ILE A 275
 None
 0.80A 3b7pB-1xj5A:
43.0		 3b7pB-1xj5A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 TRP A  55
GLU A 236
TYR A 270
PRO A 271
ILE A 275
 None
 1.02A 3b7pB-1xj5A:
43.0		 3b7pB-1xj5A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xj5 SPERMIDINE SYNTHASE
1

(Arabidopsis
thaliana) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		9 TRP A  55
TYR A 106
ASP A 131
ASP A 201
ASP A 204
GLN A 234
TYR A 270
PRO A 271
ILE A 275
 None
 0.73A 3b7pB-1xj5A:
43.0		 3b7pB-1xj5A:
46.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a02 FERRIC-PSEUDOBACTIN
358 RECEPTOR

(Pseudomonas
putida) 		PF07660
(STN) 		5 TRP A   4
TYR A  64
ASP A  48
GLN A  50
ILE A  66
 None
 1.25A 3b7pB-2a02A:
undetectable		 3b7pB-2a02A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA

(Desulfovibrio
vulgaris) 		PF02335
(Cytochrom_C552) 		5 TYR A  64
ASP A  68
ASP A 182
GLU A  47
TYR A  61
 HEM  A1002 (-3.7A)
None
None
None
HEM  A1002 ( 4.4A)
 1.18A 3b7pB-2j7aA:
undetectable		 3b7pB-2j7aA:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		11 TRP A  51
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLN A 229
TYR A 264
PRO A 265
ILE A 269
 None
S4M  A 501 (-4.1A)
S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
None
None
None
None
 0.28A 3b7pB-2pt6A:
49.6		 3b7pB-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pt6 SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 TYR A 102
HIS A 103
ASP A 127
ASP A 196
ILE A 259
 S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
 1.35A 3b7pB-2pt6A:
49.6		 3b7pB-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		8 GLN A  53
TYR A  62
HIS A  63
ASP A  87
ASP A 161
ASP A 164
GLN A 194
TYR A 229
 AG3  A1001 (-3.2A)
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.0A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
 0.47A 3b7pB-2zsuA:
37.5		 3b7pB-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLN A  53
TYR A  62
HIS A  63
GLU A 204
TYR A 229
 AG3  A1001 (-3.2A)
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
None
AG3  A1001 (-3.7A)
 0.96A 3b7pB-2zsuA:
37.5		 3b7pB-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLN A  54
TYR A  63
HIS A  64
ASP A 158
GLN A 194
 MTA  A 315 (-2.4A)
None
None
MTA  A 315 (-4.9A)
None
 0.81A 3b7pB-3anxA:
35.1		 3b7pB-3anxA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 TYR A  63
HIS A  64
ASP A 158
ASP A 161
GLN A 194
 None
None
MTA  A 315 (-4.9A)
None
None
 0.97A 3b7pB-3anxA:
35.1		 3b7pB-3anxA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 TYR A 177
ASP A 201
ASP A 276
ASP A 167
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 (-3.1A)
SPM  A 501 (-3.5A)
 1.04A 3b7pB-3c6mA:
25.6		 3b7pB-3c6mA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 TYR A 177
ASP A 201
ASP A 276
GLN A 315
TYR A 351
 SPM  A 501 (-4.2A)
SPM  A 501 ( 3.8A)
SPM  A 501 ( 3.2A)
SPM  A 501 ( 4.0A)
SPM  A 501 (-3.5A)
 0.70A 3b7pB-3c6mA:
25.6		 3b7pB-3c6mA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o4f SPERMIDINE SYNTHASE

(Escherichia
coli) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLN A  54
ASP A  88
ASP A 158
GLN A 191
TYR A 226
 None
 1.20A 3b7pB-3o4fA:
33.7		 3b7pB-3o4fA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o4f SPERMIDINE SYNTHASE

(Escherichia
coli) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLN A  54
HIS A  64
ASP A  88
GLN A 191
GLU A 201
 None
 1.31A 3b7pB-3o4fA:
33.7		 3b7pB-3o4fA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o4f SPERMIDINE SYNTHASE

(Escherichia
coli) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		6 GLN A  54
TYR A  63
HIS A  64
ASP A  88
GLN A 191
TYR A 226
 None
 0.66A 3b7pB-3o4fA:
33.7		 3b7pB-3o4fA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		7 GLN A  70
TYR A  79
ASP A 104
ASP A 173
GLU A 208
TYR A 241
ILE A 246
 DSH  A 303 (-4.1A)
DSH  A 303 ( 4.9A)
DSH  A 303 (-3.3A)
DSH  A 303 (-3.0A)
None
None
None
 1.00A 3b7pB-3rw9A:
42.8		 3b7pB-3rw9A:
42.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3rw9 SPERMIDINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		9 TRP A  28
GLN A  70
TYR A  79
ASP A 104
ASP A 173
GLN A 206
TYR A 241
PRO A 242
ILE A 246
 None
DSH  A 303 (-4.1A)
DSH  A 303 ( 4.9A)
DSH  A 303 (-3.3A)
DSH  A 303 (-3.0A)
None
None
None
None
 0.65A 3b7pB-3rw9A:
42.8		 3b7pB-3rw9A:
42.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		5 ASP A 453
ASP A 430
GLN A 455
GLU A 196
ILE A 437
 None
 1.22A 3b7pB-3vgfA:
undetectable		 3b7pB-3vgfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1d HYDANTOIN TRANSPORT
PROTEIN

(Microbacterium
liquefaciens) 		PF02133
(Transp_cyt_pur) 		5 GLN A 245
TYR A 381
ASP A 249
GLU A 459
ILE A 389
 None
 1.42A 3b7pB-4d1dA:
undetectable		 3b7pB-4d1dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 TRP A 315
HIS A 277
ASP A 359
GLN A 354
ILE A 124
 None
EPE  A 602 (-3.7A)
EPE  A 602 ( 4.6A)
None
None
 1.22A 3b7pB-4je5A:
4.7		 3b7pB-4je5A:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 HIS A 103
ASP A 196
TYR A 264
PRO A 265
ILE A 261
 None
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-3.4A)
None
None
 1.40A 3b7pB-4uoeA:
49.4		 3b7pB-4uoeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uoe SPERMIDINE SYNTHASE

(Plasmodium
falciparum) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		11 TRP A  51
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLN A 229
TYR A 264
PRO A 265
ILE A 269
 None
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-4.3A)
None
MTA  A 401 (-4.3A)
4ZY  A 501 ( 3.6A)
4ZY  A 501 (-2.5A)
4ZY  A 501 (-4.2A)
4ZY  A 501 (-3.4A)
None
4ZY  A 501 ( 4.7A)
 0.31A 3b7pB-4uoeA:
49.4		 3b7pB-4uoeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		5 TRP A 361
GLN A 422
ASP A  39
ASP A 416
ILE A 419
 None
None
None
3GC  A 501 (-2.8A)
CL  A 512 ( 4.1A)
 1.24A 3b7pB-4x8dA:
undetectable		 3b7pB-4x8dA:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		8 GLN A  64
TYR A  73
HIS A  74
ASP A  98
ASP A 168
GLN A 201
TYR A 237
PRO A 238
 S4M  A 301 (-4.2A)
S4M  A 301 (-4.4A)
S4M  A 301 (-4.0A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
None
 0.76A 3b7pB-4yv2A:
38.4		 3b7pB-4yv2A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		8 GLN A  64
TYR A  73
HIS A  74
ASP A  98
ASP A 168
TYR A 237
PRO A 238
ILE A 242
 S4M  A 301 (-4.2A)
S4M  A 301 (-4.4A)
S4M  A 301 (-4.0A)
S4M  A 301 (-3.1A)
S4M  A 301 (-3.1A)
None
None
None
 0.59A 3b7pB-4yv2A:
38.4		 3b7pB-4yv2A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLN A 201
HIS A  74
ASP A 168
TYR A 237
PRO A 238
 None
S4M  A 301 (-4.0A)
S4M  A 301 (-3.1A)
None
None
 1.40A 3b7pB-4yv2A:
38.4		 3b7pB-4yv2A:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1p CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		5 GLN A 283
TYR A 260
ASP A 279
ASP A 247
ILE A 251
 None
 1.45A 3b7pB-4z1pA:
undetectable		 3b7pB-4z1pA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN BETA-2

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 TYR B 279
HIS B 246
ASP B 209
ASP B 151
ILE B 256
 None
None
CA  B2003 (-3.0A)
CA  B2003 (-3.4A)
None
 1.31A 3b7pB-5e6sB:
undetectable		 3b7pB-5e6sB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 5 TYR A  74
ASP A 416
GLN A 412
GLU A 406
ILE A 408
 None
 1.36A 3b7pB-5ta1A:
undetectable		 3b7pB-5ta1A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blb HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Pseudomonas
aeruginosa) 		no annotation 5 TYR A 311
HIS A 328
ASP A 258
GLN A 309
PRO A 304
 None
 1.23A 3b7pB-6blbA:
undetectable		 3b7pB-6blbA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 5 GLN A  75
TYR A  84
HIS A  85
ASP A 178
GLN A 214
 TER  A 402 ( 4.9A)
TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
TER  A 402 ( 3.7A)
 0.78A 3b7pB-6bq6A:
35.0		 3b7pB-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 5 GLN A  75
TYR A  84
HIS A  85
ASP A 178
TYR A 251
 TER  A 402 ( 4.9A)
TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
TER  A 402 (-3.4A)
 0.62A 3b7pB-6bq6A:
35.0		 3b7pB-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 5 GLN A 214
HIS A  85
ASP A 178
TYR A 251
ILE A 248
 TER  A 402 ( 3.7A)
None
TER  A 402 (-4.1A)
TER  A 402 (-3.4A)
None
 1.30A 3b7pB-6bq6A:
35.0		 3b7pB-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 5 TYR A  84
HIS A  85
ASP A 178
ASP A 181
GLN A 214
 TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
None
TER  A 402 ( 3.7A)
 0.85A 3b7pB-6bq6A:
35.0		 3b7pB-6bq6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 5 TYR A  84
HIS A  85
ASP A 178
ASP A 181
TYR A 251
 TER  A 402 (-4.6A)
None
TER  A 402 (-4.1A)
None
TER  A 402 (-3.4A)
 0.98A 3b7pB-6bq6A:
35.0		 3b7pB-6bq6A:
18.42