SIMILAR PATTERNS OF AMINO ACIDS FOR 3B6H_B_MXDB551_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aq0 1,3-1,4-BETA-GLUCANA
SE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		4 ALA A 187
LEU A 188
ALA A 242
THR A 241
 None
 0.73A 3b6hB-1aq0A:
0.0		 3b6hB-1aq0A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 TYR B 242
ALA B 243
LEU B 247
ALA B 437
 None
 0.71A 3b6hB-1e6vB:
undetectable		 3b6hB-1e6vB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		4 ALA A 215
LEU A 216
ALA A  36
THR A  37
 None
 0.92A 3b6hB-1eyyA:
0.0		 3b6hB-1eyyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		4 TYR A 119
ALA A 118
LEU A 117
ASN A 189
 None
 0.90A 3b6hB-1f0xA:
0.0		 3b6hB-1f0xA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		4 ALA A 136
LEU A 135
ALA A 474
THR A 475
 None
 0.86A 3b6hB-1gqrA:
0.0		 3b6hB-1gqrA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ALA A  99
LEU A 102
ALA A 125
THR A 124
 None
 0.90A 3b6hB-1hkwA:
undetectable		 3b6hB-1hkwA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		4 ALA A 188
LEU A 192
ALA A 346
THR A 345
 None
 0.91A 3b6hB-1hsjA:
undetectable		 3b6hB-1hsjA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1

(Saccharomyces
cerevisiae) 		PF00398
(RrnaAD) 		4 ALA A 206
LEU A 204
ALA A 177
THR A 176
 None
 0.91A 3b6hB-1i4wA:
0.0		 3b6hB-1i4wA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 ALA A 224
LEU A 221
ALA A 157
THR A 156
ASN A 108
 None
 1.43A 3b6hB-1k72A:
undetectable		 3b6hB-1k72A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kae HISTIDINOL
DEHYDROGENASE

(Escherichia
coli) 		PF00815
(Histidinol_dh) 		4 TYR A 171
ALA A 172
LEU A 175
ALA A  91
 None
 0.74A 3b6hB-1kaeA:
undetectable		 3b6hB-1kaeA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh0 PROTEIN L

(Finegoldia
magna) 		PF02246
(B1) 		4 TYR A  36
ALA A  37
LEU A  40
THR A  17
 None
 0.91A 3b6hB-1kh0A:
undetectable		 3b6hB-1kh0A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		4 TYR A 327
ALA A 324
LEU A 323
THR A 276
 None
 0.82A 3b6hB-1kt1A:
undetectable		 3b6hB-1kt1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 ALA A 189
LEU A 193
ALA A 347
THR A 346
 None
 0.92A 3b6hB-1mg1A:
undetectable		 3b6hB-1mg1A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Pseudomonas sp.
CF600) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		4 TYR A 128
ALA A 129
LEU A 132
ALA A 102
 None
 0.87A 3b6hB-1nvmA:
undetectable		 3b6hB-1nvmA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovy 50S RIBOSOMAL
PROTEIN L18

(Geobacillus
stearothermophilus) 		PF00861
(Ribosomal_L18p) 		4 ALA A 110
ALA A  74
THR A  68
ASN A  70
 None
 0.84A 3b6hB-1ovyA:
undetectable		 3b6hB-1ovyA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
subtilis) 		PF01238
(PMI_typeI) 		4 ALA A 179
LEU A 180
ALA A  21
THR A  20
 None
FMT  A 606 ( 4.4A)
FMT  A 606 ( 4.6A)
None
 0.88A 3b6hB-1qwrA:
undetectable		 3b6hB-1qwrA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 ALA A 119
LEU A 122
ALA A  20
ASN A  22
 None
 0.86A 3b6hB-1rtrA:
2.0		 3b6hB-1rtrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH) 		4 ALA A 166
LEU A 169
ALA A 120
THR A 119
 None
 0.86A 3b6hB-1wpnA:
undetectable		 3b6hB-1wpnA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y71 KINASE-ASSOCIATED
PROTEIN B

(Bacillus cereus) 		PF08810
(KapB) 		4 TYR A  88
ALA A  38
ALA A  95
THR A  98
 None
 0.83A 3b6hB-1y71A:
undetectable		 3b6hB-1y71A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 192
LEU A 191
ALA A 266
THR A 267
 None
 0.93A 3b6hB-1zk7A:
undetectable		 3b6hB-1zk7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR B 472
ALA B 473
LEU B 476
THR B 451
 None
 0.82A 3b6hB-2a1aB:
undetectable		 3b6hB-2a1aB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		4 TYR A 166
LEU A 165
ALA A 117
THR A 118
 None
 0.87A 3b6hB-2b81A:
undetectable		 3b6hB-2b81A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsj PYRIMIDINE-NUCLEOSID
E (THYMIDINE)
PHOSPHORYLASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 TYR A 390
ALA A 325
LEU A 324
ALA A 249
 None
 0.89A 3b6hB-2dsjA:
undetectable		 3b6hB-2dsjA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Methanocaldococcus
jannaschii) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ALA A 164
LEU A 167
ALA A 110
THR A 109
 None
 0.91A 3b6hB-2eb0A:
undetectable		 3b6hB-2eb0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fna CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF01637
(ATPase_2) 		4 TYR A 268
ALA A 269
LEU A 272
THR A  40
 None
None
None
ADP  A 500 (-4.5A)
 0.85A 3b6hB-2fnaA:
undetectable		 3b6hB-2fnaA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haw MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 ALA A 166
LEU A 169
ALA A 120
THR A 119
 None
 0.87A 3b6hB-2hawA:
undetectable		 3b6hB-2hawA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2iag PROSTACYCLIN
SYNTHASE

(Homo sapiens) 		PF00067
(p450) 		4 ALA A 100
ALA A 283
THR A 284
ASN A 287
 None
HEM  A 600 (-4.4A)
HEM  A 600 (-3.9A)
HEM  A 600 (-4.2A)
 0.70A 3b6hB-2iagA:
59.7		 3b6hB-2iagA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Homo sapiens) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 ALA A 249
LEU A 223
ALA A 235
THR A 236
 None
 0.89A 3b6hB-2jbmA:
undetectable		 3b6hB-2jbmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjx URIDYLATE KINASE

(Bacillus
anthracis) 		PF00696
(AA_kinase) 		4 TYR A 143
ALA A 201
LEU A 204
ALA A 149
 None
 0.90A 3b6hB-2jjxA:
undetectable		 3b6hB-2jjxA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 ALA A  74
ALA A  55
THR A  56
ASN A  66
 None
 0.85A 3b6hB-2nlzA:
1.2		 3b6hB-2nlzA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyx PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN,
RV1404

(Mycobacterium
tuberculosis) 		PF01047
(MarR) 		4 ALA A 142
LEU A 143
ALA A  24
THR A  23
 None
 0.81A 3b6hB-2nyxA:
undetectable		 3b6hB-2nyxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		4 TYR A 107
ALA A 108
LEU A 111
ALA A 314
 None
 0.90A 3b6hB-2rfbA:
7.6		 3b6hB-2rfbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		4 TYR A 383
ALA A 384
ALA A 408
THR A 455
 None
 0.89A 3b6hB-2z5lA:
undetectable		 3b6hB-2z5lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 TYR A 196
ALA A 197
LEU A 200
ASN A 232
 None
 0.75A 3b6hB-2zq5A:
undetectable		 3b6hB-2zq5A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350

(Thermus
thermophilus) 		PF00582
(Usp) 		4 ALA A 147
LEU A 146
ALA A 133
THR A 132
 ALA  A 147 ( 0.0A)
LEU  A 146 ( 0.6A)
ALA  A 133 ( 0.0A)
THR  A 132 ( 0.8A)
 0.92A 3b6hB-3ab7A:
undetectable		 3b6hB-3ab7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjq PHAGE-RELATED
PROTEIN

(Bordetella
bronchiseptica) 		PF03864
(Phage_cap_E) 		4 ALA A 119
LEU A 120
ALA A 226
THR A 225
 PG4  A 316 ( 4.0A)
None
None
None
 0.83A 3b6hB-3bjqA:
undetectable		 3b6hB-3bjqA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		4 ALA A 255
LEU A 256
ALA A 273
THR A 274
 None
 0.90A 3b6hB-3ce9A:
undetectable		 3b6hB-3ce9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8a RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G

(Thermus
thermophilus) 		PF02527
(GidB) 		4 TYR A 152
ALA A 155
LEU A  85
ALA A 139
 None
None
None
SAH  A 303 (-3.8A)
 0.93A 3b6hB-3g8aA:
undetectable		 3b6hB-3g8aA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		4 ALA A 233
LEU A 232
ALA A 210
ASN A  59
 None
 0.82A 3b6hB-3gveA:
undetectable		 3b6hB-3gveA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1

(Streptomyces
antibioticus) 		PF16670
(PI-PLC-C1) 		4 TYR A 213
ALA A 214
LEU A 217
ALA A 170
 None
 0.93A 3b6hB-3h4xA:
undetectable		 3b6hB-3h4xA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jst PUTATIVE
PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE

(Brucella
melitensis) 		PF01329
(Pterin_4a) 		4 TYR A  52
ALA A  53
LEU A  56
THR A  82
 None
 0.92A 3b6hB-3jstA:
undetectable		 3b6hB-3jstA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7x LIN0763 PROTEIN

(Listeria
innocua) 		PF03663
(Glyco_hydro_76) 		4 ALA A  58
LEU A  60
ALA A 107
THR A 108
 None
 0.92A 3b6hB-3k7xA:
undetectable		 3b6hB-3k7xA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8u IMELYSIN PEPTIDASE

(Bacteroides
ovatus) 		PF09375
(Peptidase_M75) 		4 ALA A  55
LEU A  58
ALA A 301
THR A 300
 None
 0.75A 3b6hB-3n8uA:
1.5		 3b6hB-3n8uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ALA A 204
LEU A 207
ALA A 241
THR A 240
 None
 0.84A 3b6hB-3nv9A:
undetectable		 3b6hB-3nv9A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocr CLASS II
ALDOLASE/ADDUCIN
DOMAIN PROTEIN

(Pseudomonas
savastanoi) 		PF00596
(Aldolase_II) 		4 TYR A  40
ALA A  39
LEU A  36
ALA A 122
 None
 0.86A 3b6hB-3ocrA:
undetectable		 3b6hB-3ocrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE

(Helicobacter
pylori) 		PF08501
(Shikimate_dh_N) 		4 ALA A 134
LEU A 133
ALA A 179
THR A 180
 None
 0.72A 3b6hB-3phgA:
undetectable		 3b6hB-3phgA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcm ALANINE
AMINOTRANSFERASE 2

(Hordeum vulgare) 		PF00155
(Aminotran_1_2) 		4 TYR A 424
ALA A 425
LEU A 428
THR A 454
 None
 0.84A 3b6hB-3tcmA:
undetectable		 3b6hB-3tcmA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx8 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Corynebacterium
glutamicum) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A  42
LEU A  43
ALA A 116
THR A 117
 None
 0.87A 3b6hB-3tx8A:
undetectable		 3b6hB-3tx8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uor ABC TRANSPORTER
SUGAR BINDING
PROTEIN

(Xanthomonas
citri) 		PF13416
(SBP_bac_8) 		4 ALA A 295
LEU A 200
ALA A 368
ASN A  89
 None
 0.93A 3b6hB-3uorA:
undetectable		 3b6hB-3uorA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux4 ACID-ACTIVATED UREA
CHANNEL

(Helicobacter
pylori) 		PF02293
(AmiS_UreI) 		4 TYR A  90
ALA A  91
ALA A 156
THR A 155
 None
 0.88A 3b6hB-3ux4A:
undetectable		 3b6hB-3ux4A:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		4 ALA A 218
LEU A 219
ALA A 231
THR A 230
 None
 0.75A 3b6hB-3v8dA:
45.3		 3b6hB-3v8dA:
36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 ALA A 540
LEU A 542
ALA A 528
ASN A 506
 None
 0.77A 3b6hB-3w5nA:
undetectable		 3b6hB-3w5nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR A 520
ALA A 521
LEU A 524
THR A 410
 None
 0.78A 3b6hB-3wkyA:
undetectable		 3b6hB-3wkyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz3 TRAM PROTEIN

(Plasmid R64) 		PF11393
(T4BSS_DotI_IcmL) 		5 ALA A 137
LEU A 138
ALA A 107
THR A 106
ASN A 109
 None
 1.31A 3b6hB-3wz3A:
undetectable		 3b6hB-3wz3A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x27 CUCUMOPINE SYNTHASE

(Marinactinospora
thermotolerans) 		no annotation 4 TYR A 289
ALA A 290
LEU A 293
THR A 254
 None
 0.83A 3b6hB-3x27A:
undetectable		 3b6hB-3x27A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ch1 PROTEIN SUP-12,
ISOFORM B

(Caenorhabditis
elegans) 		PF00076
(RRM_1) 		4 TYR A 111
ALA A 110
LEU A 109
ALA A  89
 None
 0.87A 3b6hB-4ch1A:
undetectable		 3b6hB-4ch1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dth VGRG PROTEIN

(Vibrio cholerae) 		PF16671
(ACD) 		4 ALA A  20
LEU A  19
ALA A 103
THR A 104
 None
 0.93A 3b6hB-4dthA:
undetectable		 3b6hB-4dthA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		4 ALA A 188
LEU A 192
ALA A 346
THR A 345
 None
 0.90A 3b6hB-4egcA:
undetectable		 3b6hB-4egcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fq7 MALEATE CIS-TRANS
ISOMERASE

(Pseudomonas
putida) 		no annotation 4 ALA A 118
LEU A 121
ALA A 199
THR A 137
 None
 0.85A 3b6hB-4fq7A:
undetectable		 3b6hB-4fq7A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE

(Coffea
canephora) 		PF02458
(Transferase) 		4 TYR A 130
ALA A 131
ALA A 155
ASN A  24
 None
 0.92A 3b6hB-4g0bA:
undetectable		 3b6hB-4g0bA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		4 TYR A  94
ALA A  95
LEU A  98
ALA A  66
 None
 0.66A 3b6hB-4imdA:
undetectable		 3b6hB-4imdA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF08817
(YukD)
PF13416
(SBP_bac_8) 		4 ALA A 189
LEU A 193
ALA A 347
THR A 346
 None
 0.92A 3b6hB-4kv3A:
undetectable		 3b6hB-4kv3A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		4 ALA A 137
LEU A 140
ALA A  68
THR A  67
 None
 0.91A 3b6hB-4llsA:
2.5		 3b6hB-4llsA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9a ACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A  69
ALA A  70
LEU A  73
THR A 359
 None
 0.78A 3b6hB-4m9aA:
1.3		 3b6hB-4m9aA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 ALA A  84
LEU A  83
ALA A  13
THR A  12
 None
 0.80A 3b6hB-4m9xA:
undetectable		 3b6hB-4m9xA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Streptococcus
sanguinis) 		PF00268
(Ribonuc_red_sm) 		4 ALA A 181
LEU A 177
THR A 110
ASN A 112
 None
 0.90A 3b6hB-4n83A:
1.9		 3b6hB-4n83A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4neg TRYPTOPHAN SYNTHASE
BETA CHAIN

(Bacillus
anthracis) 		PF00291
(PALP) 		4 TYR A 361
ALA A 362
LEU A 365
ALA A 230
 None
 0.78A 3b6hB-4negA:
undetectable		 3b6hB-4negA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		4 TYR A 373
LEU A 332
THR A 368
ASN A   3
 None
 0.82A 3b6hB-4o5pA:
undetectable		 3b6hB-4o5pA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68

(Chaetomium
thermophilum) 		PF16969
(SRP68) 		4 ALA A 139
LEU A 142
ALA A  73
THR A  72
 None
 0.63A 3b6hB-4p3gA:
undetectable		 3b6hB-4p3gA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 ALA A 188
LEU A 192
ALA A 346
THR A 345
 None
 0.92A 3b6hB-4pe2A:
undetectable		 3b6hB-4pe2A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 TYR A 418
ALA A 419
LEU A 422
ASN A 276
 None
None
None
BMA  A 607 ( 4.9A)
 0.81A 3b6hB-4pfyA:
undetectable		 3b6hB-4pfyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 ALA A  66
LEU A  67
ALA A 155
THR A 154
 None
 0.92A 3b6hB-4q73A:
undetectable		 3b6hB-4q73A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 ALA A 190
LEU A 194
ALA A 348
THR A 347
 None
 0.91A 3b6hB-4rwfA:
undetectable		 3b6hB-4rwfA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		4 ALA A 194
LEU A 198
ALA A 352
THR A 351
 None
 0.93A 3b6hB-4wviA:
undetectable		 3b6hB-4wviA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 TYR A 271
ALA A 272
LEU A 275
THR A 185
 None
 0.87A 3b6hB-4wy5A:
undetectable		 3b6hB-4wy5A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 4 TYR A 254
ALA A 255
LEU A 258
ASN A  75
 None
None
None
ST9  A 403 (-3.4A)
 0.88A 3b6hB-4zyoA:
undetectable		 3b6hB-4zyoA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00043
(GST_C) 		4 ALA A  20
LEU A  19
ALA A 126
THR A 127
 None
 0.89A 3b6hB-5a1nA:
undetectable		 3b6hB-5a1nA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btb AFR263CP

(Eremothecium
gossypii) 		PF08652
(RAI1) 		4 ALA A 341
LEU A   9
ALA A 121
THR A 122
 None
 0.86A 3b6hB-5btbA:
undetectable		 3b6hB-5btbA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx8 LIPOPROTEIN RAGB

(Porphyromonas
gingivalis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 234
ALA A 235
LEU A 238
ALA A 157
 None
 0.45A 3b6hB-5cx8A:
undetectable		 3b6hB-5cx8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn5 PEPTIDOGLYCAN
HYDROLASE FLGJ

(Salmonella
enterica) 		PF01832
(Glucosaminidase) 		5 TYR A 286
ALA A 287
LEU A 290
ALA A 268
THR A 267
 None
 1.30A 3b6hB-5dn5A:
undetectable		 3b6hB-5dn5A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 TYR A 217
LEU A 215
ALA A  70
THR A  71
 None
 0.73A 3b6hB-5f4lA:
undetectable		 3b6hB-5f4lA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		4 ALA A-184
LEU A-180
ALA A -26
THR A -27
 None
 0.80A 3b6hB-5fsgA:
undetectable		 3b6hB-5fsgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h68 CHROMOSOME PARTITION
PROTEIN SMC

(Geobacillus
stearothermophilus) 		PF02463
(SMC_N) 		4 TYR A1131
ALA A1132
LEU A1135
ALA A  28
 None
 0.83A 3b6hB-5h68A:
undetectable		 3b6hB-5h68A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 4 TYR C 313
ALA C 312
LEU C 311
THR C 339
 None
 0.80A 3b6hB-5h9uC:
undetectable		 3b6hB-5h9uC:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh3 OXYA PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		4 ALA A 348
LEU A 347
ALA A 148
THR A 147
 HEM  A 401 ( 4.0A)
HEM  A 401 (-4.3A)
None
None
 0.87A 3b6hB-5hh3A:
16.3		 3b6hB-5hh3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl4 RING-HYDROXYLATING
DIOXYGENASE

(Sinorhizobium
meliloti) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 TYR A  32
ALA A  33
LEU A  36
ALA A  66
 None
 0.92A 3b6hB-5hl4A:
undetectable		 3b6hB-5hl4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idu ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Paraburkholderia
phymatum) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ALA A  90
LEU A  89
ALA A  32
THR A  33
 None
 0.88A 3b6hB-5iduA:
undetectable		 3b6hB-5iduA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ALA C 188
LEU C 192
ALA C 346
THR C 345
 None
 0.90A 3b6hB-5jj4C:
undetectable		 3b6hB-5jj4C:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Escherichia
coli;
Mus musculus) 		PF00027
(cNMP_binding)
PF13416
(SBP_bac_8) 		4 ALA A-181
LEU A-177
ALA A -23
THR A -24
 None
 0.91A 3b6hB-5jonA:
undetectable		 3b6hB-5jonA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3

(Bos taurus) 		PF00146
(NADHdh)
PF00507
(Oxidored_q4) 		4 ALA H  82
LEU H  83
ALA A  14
THR A  15
 None
 0.79A 3b6hB-5lc5H:
undetectable		 3b6hB-5lc5H:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 ALA A 607
LEU A 605
ALA A 566
THR A 565
 None
 0.87A 3b6hB-5m1tA:
undetectable		 3b6hB-5m1tA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii) 		no annotation 4 TYR A  81
ALA A  80
LEU A  79
THR A 122
 None
 0.93A 3b6hB-5nxnA:
undetectable		 3b6hB-5nxnA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		4 ALA A 194
LEU A 198
ALA A 352
THR A 351
 None
 0.92A 3b6hB-5ttdA:
undetectable		 3b6hB-5ttdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 4 TYR A 384
ALA A 385
LEU A 388
ALA A 418
 None
 0.88A 3b6hB-5u2oA:
undetectable		 3b6hB-5u2oA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5waq OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMD

(Neisseria
gonorrhoeae) 		no annotation 4 TYR A 110
ALA A 111
LEU A 114
ALA A  79
 None
 0.78A 3b6hB-5waqA:
undetectable		 3b6hB-5waqA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		5 TYR A 493
ALA A 494
ALA A 162
THR A 161
ASN A 440
 None
 1.23A 3b6hB-5wzrA:
undetectable		 3b6hB-5wzrA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		4 ALA A 597
LEU A 598
THR A 548
ASN A 415
 None
 0.90A 3b6hB-5x7hA:
undetectable		 3b6hB-5x7hA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b1z GLUTAMATE--TRNA
LIGASE

(Elizabethkingia
anophelis) 		PF00749
(tRNA-synt_1c) 		4 ALA A  61
LEU A  62
ALA A  24
THR A  23
 None
None
None
FMT  A 608 ( 4.4A)
 0.90A 3b6hB-6b1zA:
undetectable		 3b6hB-6b1zA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila) 		no annotation 4 TYR A 232
ALA A 233
LEU A 236
ASN A 113
 None
 0.68A 3b6hB-6b7pA:
undetectable		 3b6hB-6b7pA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7p SDED

(Legionella
pneumophila) 		no annotation 4 TYR A 232
ALA A 233
LEU A 236
THR A  72
 None
 0.91A 3b6hB-6b7pA:
undetectable		 3b6hB-6b7pA:
9.75