SIMILAR PATTERNS OF AMINO ACIDS FOR 3B2R_B_VDNB1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2v METHYLAMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 ILE A 468
LEU A 643
ALA A 418
ILE A 419
PHE A 293
 None
 1.07A 3b2rB-1a2vA:
undetectable		 3b2rB-1a2vA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3n AGGLUTININ

(Helianthus
tuberosus) 		PF01419
(Jacalin) 		5 ILE A  30
ALA A  81
ILE A  82
ILE A  35
PHE A 130
 None
 1.14A 3b2rB-1c3nA:
undetectable		 3b2rB-1c3nA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		5 ILE A 770
LEU A 840
ALA A 842
ILE A 843
ILE A 804
 None
 1.07A 3b2rB-1d5fA:
undetectable		 3b2rB-1d5fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5f E6AP HECT CATALYTIC
DOMAIN, E3 LIGASE

(Homo sapiens) 		PF00632
(HECT) 		5 ILE A 770
LEU A 840
ALA A 842
ILE A 843
PHE A 774
 None
 1.14A 3b2rB-1d5fA:
undetectable		 3b2rB-1d5fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		5 LEU A 311
ALA A 314
ILE A 316
ILE A 187
PHE A 352
 None
 0.89A 3b2rB-1ij5A:
undetectable		 3b2rB-1ij5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jik TYROSYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00579
(tRNA-synt_1b) 		5 LEU A 173
ALA A 175
ILE A 176
VAL A 144
PHE A 136
 None
 0.88A 3b2rB-1jikA:
undetectable		 3b2rB-1jikA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jny ELONGATION FACTOR
1-ALPHA

(Sulfolobus
solfataricus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ILE A 148
LEU A   9
ALA A 108
ILE A  10
ILE A 136
 None
 1.16A 3b2rB-1jnyA:
undetectable		 3b2rB-1jnyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkh MEVALONATE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ILE A  49
LEU A  82
ALA A  84
VAL A 128
ILE A  94
 None
 1.12A 3b2rB-1kkhA:
undetectable		 3b2rB-1kkhA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 ILE A 660
LEU A 686
ALA A 684
VAL A 631
ILE A 643
 None
 1.15A 3b2rB-1nugA:
undetectable		 3b2rB-1nugA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 ILE D  67
LEU D 104
ALA D 102
ILE D 103
GLN D  95
 None
 1.05A 3b2rB-1oy3D:
undetectable		 3b2rB-1oy3D:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		5 ILE A 157
ALA A 152
VAL A 196
ILE A 212
MET A 210
 None
 1.09A 3b2rB-1pe9A:
undetectable		 3b2rB-1pe9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 LEU A 139
ILE A 140
VAL A 160
ILE A 237
PHE A 193
 None
 0.90A 3b2rB-1ps9A:
undetectable		 3b2rB-1ps9A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		5 ILE A 266
LEU A  35
ALA A 118
ILE A 110
MET A  23
 NH3  A 401 (-3.9A)
None
None
NH3  A 402 ( 4.8A)
NH3  A 402 (-4.4A)
 1.07A 3b2rB-1u7gA:
undetectable		 3b2rB-1u7gA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 ILE A 656
LEU A 223
ALA A 220
ILE A 621
MET A 677
 None
 1.11A 3b2rB-1x9sA:
undetectable		 3b2rB-1x9sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		5 ILE A 656
LEU A 223
ALA A 220
ILE A 627
MET A 677
 None
 1.11A 3b2rB-1x9sA:
undetectable		 3b2rB-1x9sA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 211
HIS A 212
VAL A 380
ILE A 409
GLN A 413
PHE A 416
 IBM  A 503 (-4.6A)
None
IBM  A 503 (-4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
 0.78A 3b2rB-1zklA:
30.6		 3b2rB-1zklA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		5 ILE A 259
LEU A 227
ILE A 206
ILE A 211
PHE A 207
 None
 1.14A 3b2rB-2b9bA:
undetectable		 3b2rB-2b9bA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfr HYPOTHETICAL PROTEIN
AF1521

(Archaeoglobus
fulgidus) 		PF01661
(Macro) 		5 LEU A 124
ALA A 127
ILE A 135
VAL A  80
PHE A 137
 None
 1.15A 3b2rB-2bfrA:
undetectable		 3b2rB-2bfrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhr FTSH

(Thermus
thermophilus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 LEU A 194
ALA A 164
ILE A 323
VAL A 158
ILE A 334
 None
None
None
None
ADP  A1001 (-3.7A)
 0.89A 3b2rB-2dhrA:
undetectable		 3b2rB-2dhrA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 ILE A 167
LEU A 397
ALA A 395
ILE A 396
ILE A 179
 None
 1.07A 3b2rB-2dq3A:
undetectable		 3b2rB-2dq3A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 LEU A 643
ILE A 780
VAL A 621
ILE A 825
PHE A 798
 None
 1.10A 3b2rB-2dw4A:
undetectable		 3b2rB-2dw4A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gax HYPOTHETICAL PROTEIN
ATU0240

(Agrobacterium
fabrum) 		PF09391
(DUF2000) 		5 ILE A  80
ILE A   6
VAL A 124
ILE A   9
MET A 115
 None
 1.12A 3b2rB-2gaxA:
undetectable		 3b2rB-2gaxA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 ILE A  61
LEU A 221
ALA A 224
ILE A 225
ILE A  80
 None
 1.06A 3b2rB-2gouA:
undetectable		 3b2rB-2gouA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lt3 TRANSCRIPTIONAL
REGULATOR, CARD
FAMILY

(Myxococcus
xanthus) 		no annotation 5 ILE A 102
LEU A  60
ILE A  56
VAL A  21
ILE A  13
 None
 1.02A 3b2rB-2lt3A:
undetectable		 3b2rB-2lt3A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz4 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Homo sapiens) 		PF00076
(RRM_1) 		5 ILE A  21
LEU A  30
ALA A  32
ILE A  33
PHE A  77
 None
 0.94A 3b2rB-2nz4A:
undetectable		 3b2rB-2nz4A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 371
HIS A 372
LEU A 531
GLN A 581
PHE A 584
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
 0.49A 3b2rB-2qykA:
31.5		 3b2rB-2qykA:
29.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		5 TYR A 680
HIS A 681
VAL A 853
GLN A 887
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
IBM  A   3 ( 4.8A)
IBM  A   3 (-3.3A)
IBM  A   3 (-3.6A)
 0.41A 3b2rB-2r8qA:
33.4		 3b2rB-2r8qA:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rtx PEPTIDYL-TRNA
HYDROLASE YAEJ

(Escherichia
coli) 		PF00472
(RF-1) 		5 ILE A   2
LEU A  48
ILE A  43
ILE A  72
PHE A  41
 None
 1.10A 3b2rB-2rtxA:
undetectable		 3b2rB-2rtxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x06 L-SULFOLACTATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF02615
(Ldh_2) 		5 TYR A 342
ILE A  12
ILE A 331
ILE A 320
PHE A  49
 None
 1.08A 3b2rB-2x06A:
undetectable		 3b2rB-2x06A:
23.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 612
HIS A 613
LEU A 765
ALA A 767
ILE A 768
VAL A 782
ILE A 813
MET A 816
GLN A 817
PHE A 820
 None
MG  A 877 (-4.4A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
 0.41A 3b2rB-3bjcA:
45.7		 3b2rB-3bjcA:
38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 555
HIS A 556
ILE A 774
GLN A 778
PHE A 781
 None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.55A 3b2rB-3ecnA:
30.7		 3b2rB-3ecnA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		5 LEU A 453
ILE A 233
VAL A 169
ILE A 257
PHE A 229
 None
None
BFD  A 170 ( 3.0A)
None
None
 1.10A 3b2rB-3ef1A:
undetectable		 3b2rB-3ef1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE

(Bacillus
subtilis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 HIS A 161
LEU A  45
ALA A  54
ILE A  43
ILE A   3
 None
 1.16A 3b2rB-3egoA:
undetectable		 3b2rB-3egoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 325
HIS A 326
LEU A 485
GLN A 535
PHE A 538
 None
D71  A 901 (-4.5A)
None
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
 0.73A 3b2rB-3g4gA:
31.1		 3b2rB-3g4gA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		5 TYR A 141
ILE A  73
VAL A 137
MET A  99
PHE A 101
 None
 1.14A 3b2rB-3g7uA:
undetectable		 3b2rB-3g7uA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 278
ILE A 272
ILE A 257
GLN A 253
PHE A 250
 None
 1.07A 3b2rB-3hpfA:
undetectable		 3b2rB-3hpfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 TYR A 655
HIS A 656
LEU A 809
GLN A 859
PHE A 862
 None
 0.68A 3b2rB-3ibjA:
36.7		 3b2rB-3ibjA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 TYR A 655
HIS A 656
LEU A 809
ILE A 855
PHE A 862
 None
 0.60A 3b2rB-3ibjA:
36.7		 3b2rB-3ibjA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipw HYDROLASE TATD
FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01026
(TatD_DNase) 		5 ILE A 214
ALA A 271
ILE A 270
VAL A 289
ILE A   8
 None
 0.97A 3b2rB-3ipwA:
undetectable		 3b2rB-3ipwA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg4 UNCHARACTERIZED
PROTEIN

([Mannheimia]
succiniciproducens) 		PF09704
(Cas_Cas5d) 		5 LEU A   7
ALA A 118
ILE A   5
MET A 138
PHE A 139
 None
 1.06A 3b2rB-3kg4A:
undetectable		 3b2rB-3kg4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 308
LEU A 295
ALA A 298
ILE A 300
ILE A 364
 None
 1.10A 3b2rB-3kzuA:
undetectable		 3b2rB-3kzuA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		5 ILE A 160
ALA A 167
ILE A 166
VAL A  12
ILE A  19
 None
 1.11A 3b2rB-3l6rA:
undetectable		 3b2rB-3l6rA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 635
LEU A 633
ALA A 613
ILE A 614
PHE A 653
 None
 1.03A 3b2rB-3m49A:
undetectable		 3b2rB-3m49A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3max HISTONE DEACETYLASE
2

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 HIS A  73
LEU A 166
ALA A 164
ILE A 165
PHE A 192
 None
 1.14A 3b2rB-3maxA:
undetectable		 3b2rB-3maxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt1 PUTATIVE
CARBOXYNORSPERMIDINE
DECARBOXYLASE
PROTEIN

(Sinorhizobium
meliloti) 		PF00278
(Orn_DAP_Arg_deC) 		5 ILE A 156
LEU A 187
ALA A 189
ILE A 188
PHE A 159
 None
 0.98A 3b2rB-3mt1A:
undetectable		 3b2rB-3mt1A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbu GLUCOSE-6-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF00342
(PGI) 		5 ILE A 335
LEU A 485
ALA A 487
ILE A 486
PHE A 345
 None
 1.14A 3b2rB-3nbuA:
undetectable		 3b2rB-3nbuA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 233
HIS A 234
LEU A 393
GLN A 443
PHE A 446
 None
None
None
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
 0.61A 3b2rB-3o57A:
31.3		 3b2rB-3o57A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt3 E3 UBIQUITIN-PROTEIN
LIGASE UBR5

(Homo sapiens) 		PF00632
(HECT) 		5 ILE A2717
LEU A2788
ALA A2790
ILE A2791
ILE A2752
 None
 1.14A 3b2rB-3pt3A:
undetectable		 3b2rB-3pt3A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 159
HIS A 160
LEU A 319
GLN A 369
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
LEU  A 319 ( 0.6A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.45A 3b2rB-3sl5A:
31.6		 3b2rB-3sl5A:
29.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 524
HIS A 525
LEU A 675
GLN A 726
PHE A 729
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
C1L  A   1 (-4.3A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
 0.54A 3b2rB-3ui7A:
36.2		 3b2rB-3ui7A:
40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwd PHOSPHOGLYCERATE
KINASE

(Bacillus
anthracis) 		PF00162
(PGK) 		5 HIS A 231
ALA A 222
ILE A 217
ILE A 302
PHE A 260
 None
 1.06A 3b2rB-3uwdA:
undetectable		 3b2rB-3uwdA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		5 TYR A 367
HIS A 368
ALA A 524
GLN A 570
PHE A 573
 WYQ  A 701 (-4.5A)
None
None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.66A 3b2rB-3v94A:
30.2		 3b2rB-3v94A:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx HISTONE DEACETYLASE
1

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 HIS B  68
LEU B 161
ALA B 159
ILE B 160
PHE B 187
 None
 1.10A 3b2rB-4bkxB:
undetectable		 3b2rB-4bkxB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5r A49

(Vaccinia virus) 		PF06489
(Orthopox_A49R) 		5 ILE A 113
LEU A 106
ILE A 150
VAL A  68
PHE A  61
 None
 1.15A 3b2rB-4d5rA:
undetectable		 3b2rB-4d5rA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		5 ILE A  82
LEU A  62
ALA A  60
ILE A  49
VAL A  90
 None
 1.16A 3b2rB-4glfA:
undetectable		 3b2rB-4glfA:
21.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 655
HIS A 656
LEU A 809
ILE A 855
GLN A 859
PHE A 862
 None
 0.61A 3b2rB-4htzA:
35.7		 3b2rB-4htzA:
35.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		5 TYR A 668
HIS A 669
VAL A 840
GLN A 874
PHE A 877
 None
 0.59A 3b2rB-4i15A:
32.5		 3b2rB-4i15A:
31.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		5 ILE A  56
LEU A  93
ILE A  92
ILE A  75
PHE A  70
 None
 1.05A 3b2rB-4ifqA:
undetectable		 3b2rB-4ifqA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jis RIBITOL-5-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		5 ILE A  32
LEU A 231
ALA A 229
ILE A 230
PHE A 116
 None
 1.12A 3b2rB-4jisA:
undetectable		 3b2rB-4jisA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxz GC1008 HEAVY CHAIN
TRANSFORMING GROWTH
FACTOR BETA-2

(Homo sapiens) 		PF00019
(TGF_beta)
PF07654
(C1-set)
PF07686
(V-set) 		5 ILE A  88
ALA A  41
ILE A  22
ILE H  54
PHE A  24
 None
 1.15A 3b2rB-4kxzA:
undetectable		 3b2rB-4kxzA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		5 LEU A 315
ALA A 311
ILE A 314
VAL A  87
ILE A 301
 None
 1.09A 3b2rB-4l5iA:
undetectable		 3b2rB-4l5iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mna LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 645
ILE A 641
VAL A 693
ILE A 689
PHE A 680
 None
 1.07A 3b2rB-4mnaA:
undetectable		 3b2rB-4mnaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 5 TYR A 223
ILE A 217
LEU A 264
VAL A 222
ILE A 180
 None
 1.14A 3b2rB-4nuzA:
undetectable		 3b2rB-4nuzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5p THIJ/PFPI FAMILY
PROTEIN

(Francisella
tularensis) 		PF01965
(DJ-1_PfpI) 		5 ILE A  44
LEU A   5
ALA A  95
ILE A  96
ILE A 131
 None
 1.10A 3b2rB-4p5pA:
undetectable		 3b2rB-4p5pA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkd U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
A,U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA

(Homo sapiens;
Sus scrofa) 		PF00076
(RRM_1)
PF12220
(U1snRNP70_N) 		5 ILE B  21
LEU B  30
ALA B  32
ILE B  33
PHE B  77
 None
 0.87A 3b2rB-4pkdB:
undetectable		 3b2rB-4pkdB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl2 DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN

(Escherichia
coli) 		no annotation 5 ILE B 170
ALA B 191
ILE B 149
VAL B 119
ILE B  97
 None
 1.09A 3b2rB-4pl2B:
undetectable		 3b2rB-4pl2B:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5r GLUTATHIONE
S-TRANSFERASE

(Blattella
germanica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 189
ALA A 191
ILE A 192
ILE A  19
PHE A 155
 None
 1.06A 3b2rB-4q5rA:
undetectable		 3b2rB-4q5rA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 HIS A 581
ILE A 584
ILE A 684
ILE A 721
PHE A 680
 None
 1.15A 3b2rB-4r04A:
undetectable		 3b2rB-4r04A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7b CHOLINE KINASE

(Streptococcus
pneumoniae) 		PF01633
(Choline_kinase) 		5 HIS A 117
ILE A 112
LEU A 210
ALA A 209
PHE A 182
 None
 0.98A 3b2rB-4r7bA:
undetectable		 3b2rB-4r7bA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF13200
(DUF4015) 		5 ILE A 238
LEU A 218
ALA A 222
ILE A 219
PHE A 265
 None
 0.95A 3b2rB-4s1aA:
undetectable		 3b2rB-4s1aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1j FIMBRIAL PROTEIN

(Neisseria
meningitidis) 		PF00114
(Pilin) 		5 LEU A  17
ALA A  19
ILE A  16
VAL A  56
ILE A  79
 None
 1.14A 3b2rB-4v1jA:
undetectable		 3b2rB-4v1jA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 405
HIS A 406
LEU A 565
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
 0.64A 3b2rB-4wziA:
31.4		 3b2rB-4wziA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		5 LEU A 454
ALA A 456
ILE A 451
ILE A 419
GLN A 283
 None
 1.05A 3b2rB-4yjiA:
undetectable		 3b2rB-4yjiA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ay7 XYLANASE

(Aegilops
speltoides) 		PF00331
(Glyco_hydro_10) 		5 ILE A 206
LEU A 195
ILE A 192
VAL A 235
ILE A 239
 None
 1.11A 3b2rB-5ay7A:
undetectable		 3b2rB-5ay7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 5 ILE A1212
LEU A1185
ILE A1183
ILE A1124
PHE A1170
 None
 1.00A 3b2rB-5b2oA:
undetectable		 3b2rB-5b2oA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP3

(Enterovirus D) 		PF00073
(Rhv) 		5 LEU C 200
ILE C  71
ILE C 213
MET C 118
PHE C 119
 None
 1.12A 3b2rB-5bnnC:
undetectable		 3b2rB-5bnnC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		5 ILE A 101
LEU A 342
ALA A 345
ILE A 346
VAL A 392
 None
 0.96A 3b2rB-5ddsA:
undetectable		 3b2rB-5ddsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		5 ILE A 469
LEU A 495
ALA A 497
ILE A 490
VAL A 518
 None
 1.01A 3b2rB-5dooA:
undetectable		 3b2rB-5dooA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5er3 SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13407
(Peripla_BP_4) 		5 ILE A 350
ALA A 324
ILE A 325
VAL A 114
ILE A  98
 None
 1.15A 3b2rB-5er3A:
undetectable		 3b2rB-5er3A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ILE B 552
ILE B 586
VAL B 591
ILE B 600
PHE B 580
 None
 1.15A 3b2rB-5gqrB:
undetectable		 3b2rB-5gqrB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		5 ILE A 249
LEU A 237
ILE A 292
ILE A 311
PHE A 306
 None
 1.15A 3b2rB-5gu6A:
undetectable		 3b2rB-5gu6A:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 5 TYR A 668
HIS A 669
VAL A 841
GLN A 875
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.6A)
LLN  A1003 (-3.0A)
LLN  A1003 (-3.8A)
 0.43A 3b2rB-5h2rA:
33.1		 3b2rB-5h2rA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 ILE A   7
LEU A 437
ALA A 409
ILE A 407
ILE A 162
 None
 1.09A 3b2rB-5habA:
undetectable		 3b2rB-5habA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 TYR A 478
ILE A 622
LEU A 650
ALA A 648
ILE A 613
 None
 1.08A 3b2rB-5hdtA:
undetectable		 3b2rB-5hdtA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(uncultured
marine
bacterium) 		PF03480
(DctP) 		5 HIS A 145
ILE A 175
LEU A 234
ILE A 150
ILE A 203
 PHB  A 401 ( 4.2A)
None
None
None
None
 1.05A 3b2rB-5i5pA:
undetectable		 3b2rB-5i5pA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icg (S)-NORCOCLAURINE
6-O-METHYLTRANSFERAS
E

(Thalictrum
flavum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 LEU A 172
ALA A 176
ILE A 173
ILE A 286
GLN A 342
 None
 1.12A 3b2rB-5icgA:
undetectable		 3b2rB-5icgA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		5 ILE A 450
ALA A 398
ILE A 396
VAL A 370
PHE A 360
 None
 1.14A 3b2rB-5jbgA:
undetectable		 3b2rB-5jbgA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng7 EPOXIDE HYDROLASE

(metagenome) 		no annotation 6 TYR A 148
ALA A 243
ILE A 244
VAL A 149
ILE A 218
MET A 133
 None
 1.32A 3b2rB-5ng7A:
undetectable		 3b2rB-5ng7A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 TYR A 405
HIS A 406
LEU A 565
GLN A 615
PHE A 618
 None
None
9VE  A 801 (-4.7A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
 0.69A 3b2rB-5ohjA:
31.5		 3b2rB-5ohjA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 5 LEU A 485
ALA A 489
ILE A 486
VAL A 502
PHE A 514
 None
 0.93A 3b2rB-5ot1A:
undetectable		 3b2rB-5ot1A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 ILE A  95
LEU A 130
ALA A 146
ILE A 137
VAL A 110
 None
 1.15A 3b2rB-5ujsA:
undetectable		 3b2rB-5ujsA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 5 ILE A 284
ALA A 122
VAL A 249
ILE A 240
PHE A 233
 None
 1.08A 3b2rB-5wc2A:
undetectable		 3b2rB-5wc2A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 5 TYR A 159
HIS A 160
LEU A 319
GLN A 369
PHE A 372
 AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
 0.66A 3b2rB-5wh6A:
31.7		 3b2rB-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhz PROBABLE
ENDONUCLEASE 4

(Mycobacterium
tuberculosis) 		no annotation 5 ILE A 157
LEU A 148
ALA A 146
ILE A 145
ILE A 187
 None
 1.13A 3b2rB-5zhzA:
undetectable		 3b2rB-5zhzA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4h NUCLEOPORIN GLE1

(Chaetomium
thermophilum) 		no annotation 5 ILE A 330
ALA A 426
VAL A 351
ILE A 368
PHE A 375
 None
 1.14A 3b2rB-6b4hA:
undetectable		 3b2rB-6b4hA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzc GLUCOSE-6-PHOSPHATE
ISOMERASE

(Elizabethkingia
anophelis) 		no annotation 5 ILE A 334
LEU A 484
ALA A 486
ILE A 485
PHE A 344
 None
 1.15A 3b2rB-6bzcA:
undetectable		 3b2rB-6bzcA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmn TAR-BINDING PROTEIN
6.7

(Oryctolagus
cuniculus) 		no annotation 5 ILE A  21
LEU A  30
ALA A  32
ILE A  33
PHE A  77
 None
 0.95A 3b2rB-6cmnA:
undetectable		 3b2rB-6cmnA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4j U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Drosophila
melanogaster) 		no annotation 5 ILE C  18
LEU C  27
ALA C  29
ILE C  30
PHE C  74
 None
 0.89A 3b2rB-6f4jC:
undetectable		 3b2rB-6f4jC:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gww PEROXIREDOXIN

(Sulfolobus
islandicus) 		no annotation 5 LEU A 154
ALA A 156
ILE A 157
VAL A 127
PHE A  63
 None
 1.10A 3b2rB-6gwwA:
undetectable		 3b2rB-6gwwA:
13.00