SIMILAR PATTERNS OF AMINO ACIDS FOR 3B2R_A_VDNA1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a2v | METHYLAMINE OXIDASE (Ogataea angusta) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3) | 5 | ILE A 468LEU A 643ALA A 418ILE A 419PHE A 293 | None | 1.06A | 3b2rA-1a2vA:undetectable | 3b2rA-1a2vA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b0b | HEMOGLOBIN (Phacoidespectinatus) |
PF00042(Globin) | 5 | ALA A 108VAL A 39PHE A 43MET A 30PHE A 28 | NoneHEM A 144 ( 3.6A)HEM A 144 ( 3.8A)NoneNone | 1.09A | 3b2rA-1b0bA:undetectable | 3b2rA-1b0bA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1by7 | PROTEIN (PLASMINOGENACTIVATORINHIBITOR-2) (Homo sapiens) |
PF00079(Serpin) | 5 | LEU A 314ALA A 358PHE A 16ILE A 406PHE A 396 | None | 1.05A | 3b2rA-1by7A:undetectable | 3b2rA-1by7A:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d5f | E6AP HECT CATALYTICDOMAIN, E3 LIGASE (Homo sapiens) |
PF00632(HECT) | 5 | ILE A 770LEU A 840ALA A 842ILE A 843ILE A 804 | None | 1.03A | 3b2rA-1d5fA:undetectable | 3b2rA-1d5fA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g6o | CAG-ALPHA (Helicobacterpylori) |
PF00437(T2SSE) | 5 | ILE A 164LEU A 269ILE A 188VAL A 314PHE A 325 | None | 1.11A | 3b2rA-1g6oA:undetectable | 3b2rA-1g6oA:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gaj | HIGH-AFFINITYBRANCHED CHAIN AMINOACID TRANSPORTATP-BINDING PROTEIN (Methanocaldococcusjannaschii) |
PF00005(ABC_tran) | 5 | ILE A 28LEU A 23ALA A 59VAL A 64ILE A 84 | None | 1.00A | 3b2rA-1gajA:undetectable | 3b2rA-1gajA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ij5 | PLASMODIAL SPECIFICLAV1-2 PROTEIN (Physarumpolycephalum) |
PF13202(EF-hand_5) | 5 | LEU A 311ALA A 314ILE A 316ILE A 187PHE A 352 | None | 0.91A | 3b2rA-1ij5A:2.5 | 3b2rA-1ij5A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jik | TYROSYL-TRNASYNTHETASE (Staphylococcusaureus) |
PF00579(tRNA-synt_1b) | 5 | LEU A 173ALA A 175ILE A 176VAL A 144PHE A 136 | None | 0.87A | 3b2rA-1jikA:undetectable | 3b2rA-1jikA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oy3 | TRANSCRIPTION FACTORINHIBITORI-KAPPA-B-BETA (Mus musculus) |
PF12796(Ank_2)PF13637(Ank_4) | 5 | ILE D 67LEU D 104ALA D 102ILE D 103GLN D 95 | None | 1.05A | 3b2rA-1oy3D:undetectable | 3b2rA-1oy3D:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ps9 | 2,4-DIENOYL-COAREDUCTASE (Escherichiacoli) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 5 | LEU A 139ILE A 140VAL A 160ILE A 237PHE A 193 | None | 0.86A | 3b2rA-1ps9A:undetectable | 3b2rA-1ps9A:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1soj | CGMP-INHIBITED3',5'-CYCLICPHOSPHODIESTERASE B (Homo sapiens) |
PF00233(PDEase_I) | 5 | TYR A 736HIS A 737PHE A 959GLN A 988PHE A 991 | IBM A2111 (-4.5A)IBM A2111 ( 4.8A)NoneIBM A2111 (-3.3A)IBM A2111 (-3.6A) | 0.50A | 3b2rA-1sojA:30.1 | 3b2rA-1sojA:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7g | PROBABLE AMMONIUMTRANSPORTER (Escherichiacoli) |
PF00909(Ammonium_transp) | 5 | ILE A 266LEU A 35ALA A 118ILE A 110MET A 23 | NH3 A 401 (-3.9A)NoneNoneNH3 A 402 ( 4.8A)NH3 A 402 (-4.4A) | 1.12A | 3b2rA-1u7gA:undetectable | 3b2rA-1u7gA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1us4 | PUTATIVE GLUR0LIGAND BINDING CORE (Thermusthermophilus) |
PF16868(NMT1_3) | 5 | ILE A 39LEU A 108ALA A 291PHE A 264PHE A 275 | None | 1.01A | 3b2rA-1us4A:undetectable | 3b2rA-1us4A:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5w | MEIOTICRECOMBINATIONPROTEIN DMC1/LIM15HOMOLOG (Homo sapiens) |
PF08423(Rad51) | 5 | ILE A 335ALA A 124ILE A 301ILE A 101PHE A 108 | None | 1.06A | 3b2rA-1v5wA:undetectable | 3b2rA-1v5wA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zkl | HIGH-AFFINITYCAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 7A (Homo sapiens) |
PF00233(PDEase_I) | 7 | TYR A 211HIS A 212VAL A 380PHE A 384ILE A 409GLN A 413PHE A 416 | IBM A 503 (-4.6A)NoneIBM A 503 (-4.7A)IBM A 503 (-4.5A)NoneIBM A 503 (-3.0A)IBM A 503 (-3.4A) | 0.86A | 3b2rA-1zklA:30.7 | 3b2rA-1zklA:28.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dhr | FTSH (Thermusthermophilus) |
PF00004(AAA)PF01434(Peptidase_M41) | 5 | LEU A 194ALA A 164ILE A 323VAL A 158ILE A 334 | NoneNoneNoneNoneADP A1001 (-3.7A) | 0.87A | 3b2rA-2dhrA:undetectable | 3b2rA-2dhrA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq3 | SERYL-TRNASYNTHETASE (Aquifexaeolicus) |
PF00587(tRNA-synt_2b)PF02403(Seryl_tRNA_N) | 5 | ILE A 167LEU A 397ALA A 395ILE A 396ILE A 179 | None | 1.03A | 3b2rA-2dq3A:2.8 | 3b2rA-2dq3A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw4 | LYSINE-SPECIFICHISTONE DEMETHYLASE1 (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 5 | LEU A 643ILE A 780VAL A 621ILE A 825PHE A 798 | None | 1.11A | 3b2rA-2dw4A:2.8 | 3b2rA-2dw4A:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gou | OXIDOREDUCTASE,FMN-BINDING (Shewanellaoneidensis) |
PF00724(Oxidored_FMN) | 5 | ILE A 61LEU A 221ALA A 224ILE A 225ILE A 80 | None | 1.06A | 3b2rA-2gouA:undetectable | 3b2rA-2gouA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ho4 | HALOACIDDEHALOGENASE-LIKEHYDROLASE DOMAINCONTAINING 2 (Mus musculus) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 5 | ALA A 250ILE A 254VAL A 12PHE A 44MET A 41 | None | 1.12A | 3b2rA-2ho4A:undetectable | 3b2rA-2ho4A:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nz4 | U1 SMALL NUCLEARRIBONUCLEOPROTEIN A (Homo sapiens) |
PF00076(RRM_1) | 5 | ILE A 21LEU A 30ALA A 32ILE A 33PHE A 77 | None | 0.97A | 3b2rA-2nz4A:undetectable | 3b2rA-2nz4A:14.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyk | CYCLIC AMP-SPECIFICPHOSPHODIESTERASEHSPDE4A10 (Homo sapiens) |
PF00233(PDEase_I) | 6 | TYR A 371HIS A 372LEU A 531PHE A 552GLN A 581PHE A 584 | NPV A 3 (-4.4A)NPV A 3 (-4.6A)NoneNPV A 3 (-4.8A)NPV A 3 (-3.1A)NPV A 3 (-3.3A) | 0.61A | 3b2rA-2qykA:31.5 | 3b2rA-2qykA:29.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r8q | CLASS IPHOSPHODIESTERASEPDEB1 (Leishmaniamajor) |
PF00233(PDEase_I) | 6 | TYR A 680HIS A 681VAL A 853PHE A 857GLN A 887PHE A 890 | IBM A 3 ( 4.7A)IBM A 3 ( 4.8A)IBM A 3 ( 4.8A)IBM A 3 (-4.9A)IBM A 3 (-3.3A)IBM A 3 (-3.6A) | 0.55A | 3b2rA-2r8qA:33.6 | 3b2rA-2r8qA:30.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rtx | PEPTIDYL-TRNAHYDROLASE YAEJ (Escherichiacoli) |
PF00472(RF-1) | 5 | ILE A 2LEU A 48ILE A 43ILE A 72PHE A 41 | None | 1.10A | 3b2rA-2rtxA:undetectable | 3b2rA-2rtxA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x06 | L-SULFOLACTATEDEHYDROGENASE (Methanocaldococcusjannaschii) |
PF02615(Ldh_2) | 5 | TYR A 342ILE A 12ILE A 331ILE A 320PHE A 49 | None | 1.05A | 3b2rA-2x06A:undetectable | 3b2rA-2x06A:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahm | OLIGOPEPTIDASE (Geobacillus sp.MO-1) |
no annotation | 5 | ILE A 495ALA A 248ILE A 247VAL A 240PHE A 236 | None | 1.06A | 3b2rA-3ahmA:3.6 | 3b2rA-3ahmA:20.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3bjc | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I) | 11 | TYR A 612HIS A 613LEU A 765ALA A 767ILE A 768VAL A 782PHE A 786ILE A 813MET A 816GLN A 817PHE A 820 | None MG A 877 (-4.4A)WAN A 901 ( 4.7A)WAN A 901 ( 3.9A)WAN A 901 ( 4.9A)WAN A 901 ( 4.9A)WAN A 901 (-4.8A)WAN A 901 ( 4.3A)WAN A 901 (-4.3A)WAN A 901 (-3.1A)WAN A 901 (-3.7A) | 0.58A | 3b2rA-3bjcA:46.0 | 3b2rA-3bjcA:38.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3bjc | CGMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I) | 6 | TYR A 612HIS A 617LEU A 765ILE A 768GLN A 817PHE A 820 | None ZN A 876 (-3.3A)WAN A 901 ( 4.7A)WAN A 901 ( 4.9A)WAN A 901 (-3.1A)WAN A 901 (-3.7A) | 1.40A | 3b2rA-3bjcA:46.0 | 3b2rA-3bjcA:38.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e1k | GALACTOSE/LACTOSEMETABOLISMREGULATORY PROTEINGAL80 (Kluyveromyceslactis) |
PF01408(GFO_IDH_MocA) | 5 | ILE A 40ILE A 388VAL A 91PHE A 22ILE A 87 | None | 1.06A | 3b2rA-3e1kA:undetectable | 3b2rA-3e1kA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ecn | HIGH AFFINITYCAMP-SPECIFIC ANDIBMX-INSENSITIVE3',5'-CYCLICPHOSPHODIESTERASE 8A (Homo sapiens) |
PF00233(PDEase_I) | 5 | TYR A 555HIS A 556ILE A 774GLN A 778PHE A 781 | NoneNoneNoneIBM A 3 (-3.4A)IBM A 3 (-3.5A) | 0.58A | 3b2rA-3ecnA:30.5 | 3b2rA-3ecnA:25.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ef1 | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 5 | LEU A 453ILE A 233VAL A 169ILE A 257PHE A 229 | NoneNoneBFD A 170 ( 3.0A)NoneNone | 1.13A | 3b2rA-3ef1A:undetectable | 3b2rA-3ef1A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g4g | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D (Homo sapiens) |
PF00233(PDEase_I) | 6 | TYR A 325HIS A 326LEU A 485PHE A 506GLN A 535PHE A 538 | NoneD71 A 901 (-4.5A)NoneD71 A 901 (-4.8A)D71 A 901 (-3.1A)D71 A 901 (-3.9A) | 0.71A | 3b2rA-3g4gA:31.2 | 3b2rA-3g4gA:26.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gmi | UPF0348 PROTEINMJ0951 (Methanocaldococcusjannaschii) |
PF05636(HIGH_NTase1)PF16581(HIGH_NTase1_ass) | 5 | ILE A 162LEU A 184ILE A 175PHE A 218MET A 198 | None | 1.00A | 3b2rA-3gmiA:undetectable | 3b2rA-3gmiA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hbj | FLAVONOID3-O-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 5 | ILE A 231LEU A 383ILE A 382ILE A 161PHE A 182 | None | 1.02A | 3b2rA-3hbjA:undetectable | 3b2rA-3hbjA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpf | MUCONATECYCLOISOMERASE (Oceanobacillusiheyensis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 278ILE A 272ILE A 257GLN A 253PHE A 250 | None | 1.04A | 3b2rA-3hpfA:undetectable | 3b2rA-3hpfA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibj | CGMP-DEPENDENT3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I)PF01590(GAF)PF13185(GAF_2) | 6 | TYR A 655HIS A 656LEU A 809ILE A 855GLN A 859PHE A 862 | None | 0.85A | 3b2rA-3ibjA:36.7 | 3b2rA-3ibjA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j31 | C381 TURRET PROTEIN (Sulfolobusturretedicosahedralvirus 1) |
no annotation | 5 | LEU P 211ILE P 209VAL P 239PHE P 171ILE P 232 | None | 1.12A | 3b2rA-3j31P:undetectable | 3b2rA-3j31P:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kg4 | UNCHARACTERIZEDPROTEIN ([Mannheimia]succiniciproducens) |
PF09704(Cas_Cas5d) | 5 | LEU A 7ALA A 118ILE A 5MET A 138PHE A 139 | None | 1.03A | 3b2rA-3kg4A:undetectable | 3b2rA-3kg4A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzu | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE II (Brucellamelitensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ILE A 308LEU A 295ALA A 298ILE A 300ILE A 364 | None | 1.09A | 3b2rA-3kzuA:undetectable | 3b2rA-3kzuA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m49 | TRANSKETOLASE (Bacillusanthracis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ILE A 635LEU A 633ALA A 613ILE A 614PHE A 653 | None | 1.05A | 3b2rA-3m49A:undetectable | 3b2rA-3m49A:17.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3max | HISTONE DEACETYLASE2 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS A 73LEU A 166ALA A 164ILE A 165PHE A 192 | None | 1.09A | 3b2rA-3maxA:undetectable | 3b2rA-3maxA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mc6 | SPHINGOSINE-1-PHOSPHATE LYASE (Saccharomycescerevisiae) |
PF00282(Pyridoxal_deC) | 5 | ILE C 529LEU C 491ILE C 488PHE C 457ILE C 470 | None | 1.07A | 3b2rA-3mc6C:undetectable | 3b2rA-3mc6C:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mt1 | PUTATIVECARBOXYNORSPERMIDINEDECARBOXYLASEPROTEIN (Sinorhizobiummeliloti) |
PF00278(Orn_DAP_Arg_deC) | 5 | ILE A 156LEU A 187ALA A 189ILE A 188PHE A 159 | None | 0.97A | 3b2rA-3mt1A:undetectable | 3b2rA-3mt1A:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nbu | GLUCOSE-6-PHOSPHATEISOMERASE (Escherichiacoli) |
PF00342(PGI) | 5 | ILE A 335LEU A 485ALA A 487ILE A 486PHE A 345 | None | 1.11A | 3b2rA-3nbuA:undetectable | 3b2rA-3nbuA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o57 | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B (Homo sapiens) |
PF00233(PDEase_I) | 6 | TYR A 233HIS A 234LEU A 393PHE A 414GLN A 443PHE A 446 | NoneNoneNoneZG2 A 506 (-4.4A)ZG2 A 506 (-3.3A)ZG2 A 506 (-3.6A) | 0.62A | 3b2rA-3o57A:31.3 | 3b2rA-3o57A:28.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oks | 4-AMINOBUTYRATETRANSAMINASE (Mycolicibacteriumsmegmatis) |
PF00202(Aminotran_3) | 5 | LEU A 187ALA A 185VAL A 227PHE A 260PHE A 245 | None | 1.12A | 3b2rA-3oksA:undetectable | 3b2rA-3oksA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oyo | HEMOPEXIN FOLDPROTEIN CP4 (Vignaunguiculata) |
PF00045(Hemopexin) | 5 | LEU A 98ILE A 97VAL A 77PHE A 10ILE A 47 | None | 1.11A | 3b2rA-3oyoA:undetectable | 3b2rA-3oyoA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pt3 | E3 UBIQUITIN-PROTEINLIGASE UBR5 (Homo sapiens) |
PF00632(HECT) | 5 | ILE A2717LEU A2788ALA A2790ILE A2791ILE A2752 | None | 1.11A | 3b2rA-3pt3A:undetectable | 3b2rA-3pt3A:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r11 | ENZYME OF ENOLASESUPERFAMILY (Francisellaphilomiragia) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 286ILE A 291VAL A 248ILE A 228MET A 231 | None | 1.13A | 3b2rA-3r11A:undetectable | 3b2rA-3r11A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sl5 | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D (Homo sapiens) |
PF00233(PDEase_I) | 6 | TYR A 159HIS A 160LEU A 319PHE A 340GLN A 369PHE A 372 | TYR A 159 (-1.3A)HIS A 160 ( 1.0A)LEU A 319 ( 0.6A)PHE A 340 (-1.3A)GLN A 369 (-0.6A)PHE A 372 (-1.3A) | 0.55A | 3b2rA-3sl5A:31.7 | 3b2rA-3sl5A:29.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tos | CALS11 (Micromonosporaechinospora) |
PF05711(TylF) | 5 | LEU A 200ALA A 202ILE A 203VAL A 167PHE A 188 | NoneNoneNoneSAH A 258 (-3.6A)None | 0.98A | 3b2rA-3tosA:undetectable | 3b2rA-3tosA:21.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ui7 | CAMP ANDCAMP-INHIBITED CGMP3',5'-CYCLICPHOSPHODIESTERASE10A (Homo sapiens) |
PF00233(PDEase_I) | 6 | TYR A 524HIS A 525LEU A 675PHE A 696GLN A 726PHE A 729 | C1L A 1 ( 4.8A)C1L A 1 (-4.1A)C1L A 1 (-4.3A)C1L A 1 ( 4.7A)C1L A 1 (-2.9A)C1L A 1 (-3.5A) | 0.69A | 3b2rA-3ui7A:36.5 | 3b2rA-3ui7A:40.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ukf | UDP-GALACTOPYRANOSEMUTASE (Aspergillusfumigatus) |
PF13450(NAD_binding_8) | 5 | LEU A 157ALA A 155ILE A 154GLN A 107PHE A 106 | NoneNoneNoneGDU A 802 (-3.1A)None | 1.05A | 3b2rA-3ukfA:undetectable | 3b2rA-3ukfA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uwd | PHOSPHOGLYCERATEKINASE (Bacillusanthracis) |
PF00162(PGK) | 5 | HIS A 231ALA A 222ILE A 217ILE A 302PHE A 260 | None | 1.02A | 3b2rA-3uwdA:undetectable | 3b2rA-3uwdA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) |
PF00233(PDEase_I) | 6 | TYR A 367HIS A 368ALA A 524PHE A 542GLN A 570PHE A 573 | WYQ A 701 (-4.5A)NoneNoneWYQ A 701 (-4.7A)WYQ A 701 (-3.3A)WYQ A 701 (-3.4A) | 0.77A | 3b2rA-3v94A:30.3 | 3b2rA-3v94A:28.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bkx | HISTONE DEACETYLASE1 (Homo sapiens) |
PF00850(Hist_deacetyl) | 5 | HIS B 68LEU B 161ALA B 159ILE B 160PHE B 187 | None | 1.06A | 3b2rA-4bkxB:undetectable | 3b2rA-4bkxB:20.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4htz | CGMP-DEPENDENT3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I) | 7 | TYR A 655HIS A 656LEU A 809PHE A 830ILE A 855GLN A 859PHE A 862 | None | 0.61A | 3b2rA-4htzA:35.8 | 3b2rA-4htzA:35.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4i15 | CLASS 1PHOSPHODIESTERASEPDEB1 (Trypanosomabrucei) |
PF00233(PDEase_I) | 6 | TYR A 668HIS A 669VAL A 840PHE A 844GLN A 874PHE A 877 | None | 0.63A | 3b2rA-4i15A:32.7 | 3b2rA-4i15A:31.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ifq | NUCLEOPORIN NUP192 (Saccharomycescerevisiae) |
PF11894(Nup192) | 5 | ILE A 56LEU A 93ILE A 92ILE A 75PHE A 70 | None | 1.07A | 3b2rA-4ifqA:undetectable | 3b2rA-4ifqA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jis | RIBITOL-5-PHOSPHATECYTIDYLYLTRANSFERASE (Bacillussubtilis) |
PF01128(IspD) | 5 | ILE A 32LEU A 231ALA A 229ILE A 230PHE A 116 | None | 1.13A | 3b2rA-4jisA:undetectable | 3b2rA-4jisA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mna | LRR RECEPTOR-LIKESERINE/THREONINE-PROTEIN KINASE FLS2 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13516(LRR_6)PF13855(LRR_8) | 5 | LEU A 645ILE A 641VAL A 693ILE A 689PHE A 680 | None | 1.07A | 3b2rA-4mnaA:undetectable | 3b2rA-4mnaA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n3o | PUTATIVED-GLYCERO-D-MANNO-HEPTOSE 7-PHOSPHATEKINASE (Campylobacterjejuni) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | ILE A 84LEU A 143ALA A 141ILE A 140ILE A 41 | None | 1.13A | 3b2rA-4n3oA:undetectable | 3b2rA-4n3oA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pkd | U1 SMALL NUCLEARRIBONUCLEOPROTEINA,U1 SMALL NUCLEARRIBONUCLEOPROTEIN 70KDA (Homo sapiens;Sus scrofa) |
PF00076(RRM_1)PF12220(U1snRNP70_N) | 5 | ILE B 21LEU B 30ALA B 32ILE B 33PHE B 77 | None | 0.89A | 3b2rA-4pkdB:undetectable | 3b2rA-4pkdB:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pl2 | DUAL-SPECIFICITY RNAMETHYLTRANSFERASERLMN (Escherichiacoli) |
no annotation | 5 | ILE B 170ALA B 191ILE B 149VAL B 119ILE B 97 | None | 1.10A | 3b2rA-4pl2B:undetectable | 3b2rA-4pl2B:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q5r | GLUTATHIONES-TRANSFERASE (Blattellagermanica) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 189ALA A 191ILE A 192ILE A 19PHE A 155 | None | 1.07A | 3b2rA-4q5rA:undetectable | 3b2rA-4q5rA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qts | CRISPR TYPEIII-ASSOCIATED RAMPPROTEIN CSM3 (Methanocaldococcusjannaschii) |
PF03787(RAMPs) | 5 | ILE C 205ILE C 174VAL C 161PHE C 159ILE C 59 | None | 1.03A | 3b2rA-4qtsC:undetectable | 3b2rA-4qtsC:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qtu | PUTATIVEMETHYLTRANSFERASEBUD23 (Saccharomycescerevisiae) |
PF08241(Methyltransf_11) | 5 | ILE B 169LEU B 182PHE B 141ILE B 54PHE B 158 | None | 1.05A | 3b2rA-4qtuB:undetectable | 3b2rA-4qtuB:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7b | CHOLINE KINASE (Streptococcuspneumoniae) |
PF01633(Choline_kinase) | 5 | HIS A 117ILE A 112LEU A 210ALA A 209PHE A 182 | None | 0.97A | 3b2rA-4r7bA:undetectable | 3b2rA-4r7bA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s1a | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
PF13200(DUF4015) | 5 | ILE A 238LEU A 218ALA A 222ILE A 219PHE A 265 | None | 0.96A | 3b2rA-4s1aA:undetectable | 3b2rA-4s1aA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wzi | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B (Homo sapiens) |
PF00233(PDEase_I) | 6 | TYR A 405HIS A 406LEU A 565PHE A 586GLN A 615PHE A 618 | None MG A 804 ( 4.9A)NoneNoneNoneNone | 0.70A | 3b2rA-4wziA:31.5 | 3b2rA-4wziA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yji | ARYL ACYLAMIDASE (bacteriumCSBL00001) |
PF01425(Amidase) | 5 | LEU A 454ALA A 456ILE A 451ILE A 419GLN A 283 | None | 1.07A | 3b2rA-4yjiA:undetectable | 3b2rA-4yjiA:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ay7 | XYLANASE (Aegilopsspeltoides) |
PF00331(Glyco_hydro_10) | 5 | ILE A 206LEU A 195ILE A 192VAL A 235ILE A 239 | None | 1.13A | 3b2rA-5ay7A:undetectable | 3b2rA-5ay7A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b25 | CALCIUM/CALMODULIN-DEPENDENT3',5'-CYCLICNUCLEOTIDEPHOSPHODIESTERASE 1B (Homo sapiens) |
PF00233(PDEase_I) | 5 | TYR A 222HIS A 223PHE A 392GLN A 421PHE A 424 | None4QJ A 603 ( 4.9A)GOL A 607 (-3.9A)4QJ A 603 (-3.0A)4QJ A 603 (-3.5A) | 0.57A | 3b2rA-5b25A:30.3 | 3b2rA-5b25A:28.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b2o | CRISPR-ASSOCIATEDENDONUCLEASE CAS9 (Francisellatularensis) |
no annotation | 5 | ILE A1212LEU A1185ILE A1183ILE A1124PHE A1170 | None | 0.99A | 3b2rA-5b2oA:undetectable | 3b2rA-5b2oA:12.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dds | CRMG (Actinoalloteichussp. WH1-2216-6) |
PF00202(Aminotran_3) | 5 | ILE A 101LEU A 342ALA A 345ILE A 346VAL A 392 | None | 0.98A | 3b2rA-5ddsA:undetectable | 3b2rA-5ddsA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dgk | ACTIVE HELICASE (Staphylococcusaureus) |
PF06048(DUF927) | 5 | ILE A 486ILE A 445VAL A 452PHE A 459ILE A 482 | None | 1.07A | 3b2rA-5dgkA:undetectable | 3b2rA-5dgkA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5doo | PROTEIN LYSINEMETHYLTRANSFERASE 2 (Rickettsiatyphi) |
PF10119(MethyTransf_Reg)PF13847(Methyltransf_31) | 5 | ILE A 469LEU A 495ALA A 497ILE A 490VAL A 518 | None | 1.05A | 3b2rA-5dooA:undetectable | 3b2rA-5dooA:21.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h2r | PHOSPHODIESTERASE (Trypanosomabrucei) |
no annotation | 6 | TYR A 668HIS A 669VAL A 841PHE A 845GLN A 875PHE A 878 | LLN A1003 ( 4.8A)NoneLLN A1003 (-4.6A)LLN A1003 (-4.6A)LLN A1003 (-3.0A)LLN A1003 (-3.8A) | 0.54A | 3b2rA-5h2rA:33.2 | 3b2rA-5h2rA:33.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hab | RIBONUCLEASE J (Methanolobuspsychrophilus) |
PF07521(RMMBL)PF12706(Lactamase_B_2) | 5 | ILE A 7LEU A 437ALA A 409ILE A 407ILE A 162 | None | 1.09A | 3b2rA-5habA:undetectable | 3b2rA-5habA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdl | CELL SURFACE PROTEINSPAA (Lactobacillusrhamnosus) |
no annotation | 5 | ILE A 200LEU A 210ILE A 225PHE A 284PHE A 245 | None | 1.08A | 3b2rA-5hdlA:undetectable | 3b2rA-5hdlA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdt | SISTER CHROMATIDCOHESION PROTEINPDS5 HOMOLOG B (Homo sapiens) |
no annotation | 5 | TYR A 478ILE A 622LEU A 650ALA A 648ILE A 613 | None | 1.06A | 3b2rA-5hdtA:undetectable | 3b2rA-5hdtA:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbg | LGP2 (Gallus gallus) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 5 | ILE A 450ALA A 398ILE A 396VAL A 370PHE A 360 | None | 1.12A | 3b2rA-5jbgA:undetectable | 3b2rA-5jbgA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kiq | PLATELET-BINDINGGLYCOPROTEIN (Streptococcussanguinis) |
no annotation | 5 | ILE A 366ILE A 349VAL A 326PHE A 273PHE A 364 | None | 1.08A | 3b2rA-5kiqA:undetectable | 3b2rA-5kiqA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l3d | LYSINE-SPECIFICHISTONE DEMETHYLASE1A (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM) | 5 | LEU A 643ILE A 780VAL A 621ILE A 825PHE A 798 | None | 1.12A | 3b2rA-5l3dA:2.7 | 3b2rA-5l3dA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqc | VP1VP2 (Black queencell virus) |
PF00073(Rhv)PF08762(CRPV_capsid) | 5 | LEU B 138ALA A 114VAL B 176PHE B 175ILE B 173 | None | 1.06A | 3b2rA-5mqcB:undetectable | 3b2rA-5mqcB:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n6u | BETA-MANNOSIDASE (Dictyoglomusthermophilum) |
PF00703(Glyco_hydro_2)PF02837(Glyco_hydro_2_N) | 5 | ILE A 225ILE A 249VAL A 194PHE A 291PHE A 223 | None | 1.08A | 3b2rA-5n6uA:undetectable | 3b2rA-5n6uA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ng7 | EPOXIDE HYDROLASE (metagenome) |
no annotation | 6 | TYR A 148ALA A 243ILE A 244VAL A 149ILE A 218MET A 133 | None | 1.28A | 3b2rA-5ng7A:undetectable | 3b2rA-5ng7A:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o8x | SOLUBLE LYTICTRANSGLYCOSYLASE B (Pseudomonasaeruginosa) |
no annotation | 5 | LEU A 145ALA A 147PHE A 35GLN A 30PHE A 26 | None | 1.10A | 3b2rA-5o8xA:undetectable | 3b2rA-5o8xA:11.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ohj | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4B (Homo sapiens) |
no annotation | 6 | TYR A 405HIS A 406LEU A 565PHE A 586GLN A 615PHE A 618 | NoneNone9VE A 801 (-4.7A)9VE A 801 (-3.6A)9VE A 801 (-3.2A)9VE A 801 (-3.9A) | 0.68A | 3b2rA-5ohjA:31.5 | 3b2rA-5ohjA:13.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ot1 | PULLULANASE TYPE II,GH13 FAMILY (Thermococcuskodakarensis) |
no annotation | 5 | LEU A 485ALA A 489ILE A 486VAL A 502PHE A 514 | None | 0.97A | 3b2rA-5ot1A:undetectable | 3b2rA-5ot1A:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wc2 | PACHYTENE CHECKPOINTPROTEIN 2 HOMOLOG (Homo sapiens) |
no annotation | 5 | ILE A 284ALA A 122VAL A 249ILE A 240PHE A 233 | None | 1.09A | 3b2rA-5wc2A:undetectable | 3b2rA-5wc2A:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wh6 | CAMP-SPECIFIC3',5'-CYCLICPHOSPHODIESTERASE 4D (Homo sapiens) |
no annotation | 6 | TYR A 159HIS A 160LEU A 319PHE A 340GLN A 369PHE A 372 | AKJ A 601 ( 4.7A)NoneAKJ A 601 ( 4.6A)AKJ A 601 (-4.5A)AKJ A 601 (-3.0A)AKJ A 601 (-4.1A) | 0.68A | 3b2rA-5wh6A:31.3 | 3b2rA-5wh6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x03 | HTH-TYPETRANSCRIPTIONALREGULATORY PROTEINGABR (Bacillussubtilis) |
PF00155(Aminotran_1_2) | 5 | LEU A 378ILE A 379VAL A 390PHE A 405PHE A 401 | None | 0.89A | 3b2rA-5x03A:undetectable | 3b2rA-5x03A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ysq | TM0415 (Thermotogamaritima) |
no annotation | 5 | ALA A 31ILE A 32VAL A 65PHE A 67PHE A 57 | None | 1.01A | 3b2rA-5ysqA:undetectable | 3b2rA-5ysqA:13.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bzc | GLUCOSE-6-PHOSPHATEISOMERASE (Elizabethkingiaanophelis) |
no annotation | 5 | ILE A 334LEU A 484ALA A 486ILE A 485PHE A 344 | None | 1.12A | 3b2rA-6bzcA:undetectable | 3b2rA-6bzcA:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cmn | TAR-BINDING PROTEIN6.7 (Oryctolaguscuniculus) |
no annotation | 5 | ILE A 21LEU A 30ALA A 32ILE A 33PHE A 77 | None | 0.97A | 3b2rA-6cmnA:undetectable | 3b2rA-6cmnA:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dk2 | - (-) |
no annotation | 5 | ILE A 127LEU A 105ALA A 108ILE A 109PHE A 182 | None | 1.12A | 3b2rA-6dk2A:undetectable | 3b2rA-6dk2A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f4j | U1 SMALL NUCLEARRIBONUCLEOPROTEIN A (Drosophilamelanogaster) |
no annotation | 5 | ILE C 18LEU C 27ALA C 29ILE C 30PHE C 74 | None | 0.90A | 3b2rA-6f4jC:undetectable | 3b2rA-6f4jC:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gww | PEROXIREDOXIN (Sulfolobusislandicus) |
no annotation | 5 | LEU A 154ALA A 156ILE A 157VAL A 127PHE A 63 | None | 1.07A | 3b2rA-6gwwA:undetectable | 3b2rA-6gwwA:13.00 |