SIMILAR PATTERNS OF AMINO ACIDS FOR 3B0W_B_DGXB1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a05 3-ISOPROPYLMALATE
DEHYDROGENASE


(Acidithiobacillus
ferrooxidans)
PF00180
(Iso_dh)
5 GLN A  22
LEU A 354
ALA A  19
VAL A 320
HIS A 278
None
1.25A 3b0wB-1a05A:
0.0
3b0wB-1a05A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)


(Oryctolagus
cuniculus)
PF00464
(SHMT)
5 CYH A 344
ALA A 368
ALA A 417
LEU A 362
LEU A 302
None
1.36A 3b0wB-1cj0A:
0.6
3b0wB-1cj0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3


(Reovirus sp.)
PF00979
(Reovirus_cap)
5 GLN A  10
LEU A 315
CYH A  51
ALA A  48
ALA A 314
None
None
ZN  A1001 (-2.3A)
None
None
1.31A 3b0wB-1fn9A:
0.0
3b0wB-1fn9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ftg APOFLAVODOXIN

(Nostoc sp. PCC
7119)
PF00258
(Flavodoxin_1)
5 LEU A 163
CYH A  54
ALA A  19
LEU A  62
LEU A  69
None
1.32A 3b0wB-1ftgA:
undetectable
3b0wB-1ftgA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))


(Desulfovibrio
vulgaris)
PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10)
5 LEU L 134
MET L 105
ALA L 104
LEU L 242
LEU L 246
None
1.09A 3b0wB-1hfeL:
undetectable
3b0wB-1hfeL:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igw ISOCITRATE LYASE

(Escherichia
coli)
PF00463
(ICL)
5 LEU A 229
ALA A 209
ALA A 283
VAL A 286
PHE A 301
None
1.21A 3b0wB-1igwA:
0.0
3b0wB-1igwA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT


(Sterkiella nova)
PF02765
(POT1)
5 LEU A  41
CYH A  74
ALA A 138
ALA A  56
VAL A  58
None
1.03A 3b0wB-1k8gA:
0.0
3b0wB-1k8gA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE


(Acinetobacter
sp.)
PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
5 GLN A 230
LEU A 259
ALA A 255
VAL A 254
LEU A 185
None
1.09A 3b0wB-1krhA:
undetectable
3b0wB-1krhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Tritrichomonas
suis)
PF00478
(IMPDH)
5 GLN A  84
LEU A 250
ALA A 236
VAL A 234
LEU A 443
None
1.29A 3b0wB-1lrtA:
0.0
3b0wB-1lrtA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Tritrichomonas
suis)
PF00478
(IMPDH)
PF00571
(CBS)
5 GLN A  84
LEU A 250
ALA A 236
VAL A 234
LEU A 443
None
1.33A 3b0wB-1mewA:
undetectable
3b0wB-1mewA:
17.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA


(Rattus
norvegicus)
PF00104
(Hormone_recep)
5 GLN A 228
CYH A 262
ALA A 269
LEU A 333
HIS A 423
ARL  A 800 (-4.7A)
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
None
ARL  A 800 ( 4.3A)
1.16A 3b0wB-1nq7A:
28.9
3b0wB-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA


(Rattus
norvegicus)
PF00104
(Hormone_recep)
10 GLN A 228
LEU A 234
CYH A 262
ALA A 269
MET A 307
ALA A 310
VAL A 318
PHE A 330
LEU A 333
LEU A 338
ARL  A 800 (-4.7A)
None
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
ARL  A 800 (-3.7A)
ARL  A 800 ( 4.1A)
None
ARL  A 800 (-3.6A)
None
ARL  A 800 ( 4.8A)
0.83A 3b0wB-1nq7A:
28.9
3b0wB-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA


(Rattus
norvegicus)
PF00104
(Hormone_recep)
6 GLN A 228
LEU A 237
CYH A 262
PHE A 330
LEU A 333
LEU A 338
ARL  A 800 (-4.7A)
None
ARL  A 800 (-3.5A)
ARL  A 800 (-3.6A)
None
ARL  A 800 ( 4.8A)
1.23A 3b0wB-1nq7A:
28.9
3b0wB-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA


(Rattus
norvegicus)
PF00104
(Hormone_recep)
8 LEU A 234
CYH A 262
ALA A 269
MET A 307
ALA A 310
VAL A 318
PHE A 330
LEU A 258
None
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
ARL  A 800 (-3.7A)
ARL  A 800 ( 4.1A)
None
ARL  A 800 (-3.6A)
None
1.50A 3b0wB-1nq7A:
28.9
3b0wB-1nq7A:
49.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00004
(AAA)
PF08542
(Rep_fac_C)
5 GLN B   8
CYH C 144
VAL C  37
PHE C  51
LEU C 146
None
1.32A 3b0wB-1sxjB:
undetectable
3b0wB-1sxjB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE


(Escherichia
coli)
PF00291
(PALP)
PF00585
(Thr_dehydrat_C)
5 LEU A 409
CYH A 356
ALA A 339
VAL A 383
LEU A 448
None
1.26A 3b0wB-1tdjA:
undetectable
3b0wB-1tdjA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION


(Saccharomyces
cerevisiae)
PF14519
(Macro_2)
5 LEU A 188
ALA A 120
MET A 179
PHE A 171
LEU A 235
None
1.32A 3b0wB-1txzA:
undetectable
3b0wB-1txzA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor)
PF00232
(Glyco_hydro_1)
5 CYH A 194
MET A 300
ALA A 304
VAL A 308
LEU A 232
None
1.29A 3b0wB-1v02A:
undetectable
3b0wB-1v02A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE


(Thermus
thermophilus)
PF00294
(PfkB)
5 LEU A 123
MET A 150
ALA A 153
VAL A 160
LEU A 180
None
1.31A 3b0wB-1v19A:
undetectable
3b0wB-1v19A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)


(Thermus
thermophilus)
PF04260
(DUF436)
5 GLN A 110
LEU A 163
ALA A 167
PHE A  54
LEU A 191
None
1.30A 3b0wB-1v8dA:
undetectable
3b0wB-1v8dA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima)
PF01523
(PmbA_TldD)
5 LEU A 346
ALA A 422
MET A 227
VAL A 427
LEU A 401
None
1.14A 3b0wB-1vl4A:
undetectable
3b0wB-1vl4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima)
PF00294
(PfkB)
5 ALA A 244
ALA A 238
VAL A 236
PHE A 295
LEU A 296
None
1.23A 3b0wB-1vm7A:
undetectable
3b0wB-1vm7A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]


(Anaerobiospirillum
succiniciproducens)
PF01293
(PEPCK_ATP)
5 MET A 423
ALA A 428
VAL A 351
PHE A 241
LEU A 378
None
1.29A 3b0wB-1ytmA:
undetectable
3b0wB-1ytmA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1


(Homo sapiens)
PF00619
(CARD)
PF00931
(NB-ARC)
5 LEU A 415
VAL A 395
LEU A 487
LEU A 473
HIS A 468
None
1.35A 3b0wB-1z6tA:
undetectable
3b0wB-1z6tA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME


(Rattus
norvegicus)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 LEU A 708
ALA A 630
ALA A 667
PHE A 511
LEU A 508
None
1.29A 3b0wB-1zcjA:
undetectable
3b0wB-1zcjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E


(Bacillus
subtilis)
PF01979
(Amidohydro_1)
5 LEU A 199
MET A 182
ALA A 184
LEU A 273
LEU A 294
None
1.36A 3b0wB-2bb0A:
undetectable
3b0wB-2bb0A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE


(Thermus
thermophilus)
PF01053
(Cys_Met_Meta_PP)
5 GLN A 228
LEU A 222
ALA A 172
VAL A 174
LEU A 111
None
1.27A 3b0wB-2cb1A:
undetectable
3b0wB-2cb1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT


(Thermus
thermophilus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 LEU A 175
ALA A  62
ALA A 200
VAL A 202
LEU A 223
None
1.35A 3b0wB-2eq9A:
undetectable
3b0wB-2eq9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb4 THIOPURINE
S-METHYLTRANSFERASE


(Mus musculus)
PF05724
(TPMT)
5 LEU A 230
CYH A 211
ALA A 178
ALA A 217
HIS A  47
None
1.24A 3b0wB-2gb4A:
undetectable
3b0wB-2gb4A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnw NON-SYMBIOTIC
HEMOGLOBIN 1


(Oryza sativa)
PF00042
(Globin)
5 GLN A  87
LEU A 101
ALA A 156
VAL A 154
LEU A 126
None
None
None
HEM  A 166 (-4.4A)
None
1.29A 3b0wB-2gnwA:
undetectable
3b0wB-2gnwA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE


(Neurospora
crassa)
PF05183
(RdRP)
5 ALA A 786
ALA A 918
VAL A1015
PHE A 991
LEU A 930
None
1.33A 3b0wB-2j7nA:
undetectable
3b0wB-2j7nA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvu ARTJ

(Geobacillus
stearothermophilus)
PF00497
(SBP_bac_3)
5 MET A  54
ALA A 222
VAL A 219
PHE A 209
LEU A  75
None
1.16A 3b0wB-2pvuA:
undetectable
3b0wB-2pvuA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5v PCZA361.1

(Amycolatopsis
orientalis)
PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5)
5 LEU A  52
ALA A 243
VAL A  75
PHE A 119
LEU A 166
None
CO  A4113 ( 4.4A)
None
None
None
1.34A 3b0wB-2r5vA:
undetectable
3b0wB-2r5vA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens)
PF06418
(CTP_synth_N)
5 LEU A 130
ALA A 129
VAL A 125
PHE A 163
LEU A 209
None
1.28A 3b0wB-2vo1A:
undetectable
3b0wB-2vo1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Pseudomonas
aeruginosa)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 LEU A  97
ALA A  67
ALA A  60
PHE A 114
LEU A 306
None
1.30A 3b0wB-2x3eA:
undetectable
3b0wB-2x3eA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa)
PF12891
(Glyco_hydro_44)
5 LEU A 407
ALA A 490
ALA A 510
VAL A 451
PHE A 464
None
1.30A 3b0wB-2yjqA:
undetectable
3b0wB-2yjqA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE


(Thermus
thermophilus)
PF01555
(N6_N4_Mtase)
5 LEU A 222
ALA A 244
ALA A 252
VAL A 229
LEU A  87
None
1.22A 3b0wB-2zieA:
undetectable
3b0wB-2zieA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE


(Escherichia
coli)
PF00155
(Aminotran_1_2)
5 LEU A  20
CYH A 401
ALA A 381
VAL A 387
PHE A 337
None
1.23A 3b0wB-3aatA:
undetectable
3b0wB-3aatA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahr ERO1-LIKE PROTEIN
ALPHA


(Homo sapiens)
PF04137
(ERO1)
5 LEU A 415
ALA A 446
ALA A 314
VAL A 318
LEU A 329
None
1.28A 3b0wB-3ahrA:
undetectable
3b0wB-3ahrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE


(Mesorhizobium
japonicum)
PF01494
(FAD_binding_3)
5 LEU A 325
ALA A  14
ALA A 284
VAL A 286
LEU A 113
None
1.23A 3b0wB-3allA:
undetectable
3b0wB-3allA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF00171
(Aldedh)
5 TRP A 110
ALA A 168
ALA A 152
VAL A 154
LEU A  94
None
1.05A 3b0wB-3b4wA:
undetectable
3b0wB-3b4wA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster)
PF00004
(AAA)
PF09336
(Vps4_C)
5 LEU A 520
ALA A 626
VAL A 624
PHE A 568
LEU A 470
None
1.17A 3b0wB-3b9pA:
undetectable
3b0wB-3b9pA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE


(Pseudomonas
aeruginosa)
PF01715
(IPPT)
5 GLN A 288
LEU A 216
ALA A  15
LEU A  33
LEU A  57
TRS  A 327 ( 4.9A)
None
DPO  A 326 (-4.6A)
None
None
1.30A 3b0wB-3crrA:
undetectable
3b0wB-3crrA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti)
PF01979
(Amidohydro_1)
5 GLN A 406
ALA A 403
ALA A 316
PHE A 289
HIS A 279
None
1.19A 3b0wB-3dc8A:
undetectable
3b0wB-3dc8A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5b ISOCITRATE LYASE

(Brucella
abortus)
PF00463
(ICL)
5 LEU A 203
ALA A 221
VAL A 220
PHE A 341
LEU A 332
None
1.33A 3b0wB-3e5bA:
undetectable
3b0wB-3e5bA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9n PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE


(Corynebacterium
glutamicum)
PF00106
(adh_short)
5 LEU A  42
ALA A  80
ALA A  31
VAL A  29
LEU A 119
None
1.21A 3b0wB-3e9nA:
undetectable
3b0wB-3e9nA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF02820
(MBT)
5 CYH A 303
ALA A 243
VAL A 245
PHE A 285
LEU A 281
None
1.32A 3b0wB-3feoA:
undetectable
3b0wB-3feoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjb CYTC3

(Streptomyces
sp.)
PF05721
(PhyH)
5 LEU A 226
ALA A 258
ALA A 231
VAL A  29
PHE A  12
None
1.36A 3b0wB-3gjbA:
undetectable
3b0wB-3gjbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqj CELL INHIBITING
FACTOR (CIF)


(Photorhabdus
laumondii)
PF16374
(CIF)
5 LEU A 278
ALA A 172
VAL A 174
LEU A 208
LEU A 211
None
1.08A 3b0wB-3gqjA:
undetectable
3b0wB-3gqjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1


(Mycobacterium
tuberculosis)
PF00464
(SHMT)
5 ALA A 218
VAL A 197
PHE A 202
LEU A 205
LEU A 229
None
1.36A 3b0wB-3h7fA:
undetectable
3b0wB-3h7fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN


(Rhodospirillum
rubrum)
PF13458
(Peripla_BP_6)
5 LEU A 165
MET A 132
ALA A 131
VAL A 365
LEU A 327
None
1.35A 3b0wB-3i45A:
undetectable
3b0wB-3i45A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 LEU A 324
TRP A 169
MET A 276
ALA A 275
LEU A  67
None
1.18A 3b0wB-3i8bA:
undetectable
3b0wB-3i8bA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN


(Paenarthrobacter
aurescens)
PF05960
(DUF885)
5 LEU A 558
ALA A 557
VAL A 553
LEU A  88
LEU A  67
None
1.29A 3b0wB-3iukA:
undetectable
3b0wB-3iukA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE


(Pseudomonas
putida)
PF03446
(NAD_binding_2)
5 GLN A  31
MET A  24
ALA A  25
VAL A  14
HIS A 143
None
1.31A 3b0wB-3l6dA:
undetectable
3b0wB-3l6dA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis)
PF00463
(ICL)
5 LEU A 230
ALA A 210
ALA A 284
VAL A 287
PHE A 302
None
1.13A 3b0wB-3lg3A:
undetectable
3b0wB-3lg3A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhq ACRAB OPERON
REPRESSOR (TETR/ACRR
FAMILY)


(Salmonella
enterica)
PF00440
(TetR_N)
PF08361
(TetR_C_2)
5 ALA A 129
VAL A 126
PHE A  59
LEU A  21
LEU A  17
None
1.29A 3b0wB-3lhqA:
undetectable
3b0wB-3lhqA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD


(Bacillus
subtilis)
PF07451
(SpoVAD)
5 LEU A  81
ALA A 185
VAL A 171
PHE A 291
LEU A 294
None
1.24A 3b0wB-3lm6A:
undetectable
3b0wB-3lm6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3men ACETYLPOLYAMINE
AMINOHYDROLASE


(Burkholderia
pseudomallei)
PF00850
(Hist_deacetyl)
5 GLN A   9
CYH A 167
ALA A 149
VAL A 315
HIS A  62
None
SO4  A 401 ( 4.2A)
None
None
None
1.14A 3b0wB-3menA:
undetectable
3b0wB-3menA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN


(Homo sapiens)
PF01463
(LRRCT)
5 TRP A  21
ALA A  52
VAL A  12
LEU A  42
LEU A  61
None
1.30A 3b0wB-3rfeA:
undetectable
3b0wB-3rfeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI


(Bacillus
pumilus)
PF02384
(N6_Mtase)
PF15516
(BpuSI_N)
5 LEU A 448
ALA A 463
VAL A 511
LEU A 560
LEU A 540
None
1.35A 3b0wB-3s1sA:
undetectable
3b0wB-3s1sA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE


(Vibrio
parahaemolyticus)
PF01522
(Polysacc_deac_1)
5 ALA A 256
VAL A 253
PHE A 314
LEU A 311
LEU A 243
None
0.91A 3b0wB-3wx7A:
undetectable
3b0wB-3wx7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx ACRH
AOPB


(Aeromonas
hydrophila)
PF04888
(SseC)
no annotation
5 ALA B 235
ALA B 178
VAL B 175
LEU A  74
LEU A  86
None
1.31A 3b0wB-3wxxB:
undetectable
3b0wB-3wxxB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN


(Aequorea
victoria;
Sus scrofa)
PF00063
(Myosin_head)
PF01353
(GFP)
5 LEU A 378
ALA A 255
ALA A 342
VAL A 341
PHE A 192
None
1.18A 3b0wB-4anjA:
undetectable
3b0wB-4anjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR


(Saccharomyces
cerevisiae)
PF03372
(Exo_endo_phos)
PF13855
(LRR_8)
5 LEU D 171
ALA D 136
ALA D 168
LEU D 152
HIS D 145
None
1.33A 3b0wB-4b8cD:
undetectable
3b0wB-4b8cD:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila)
PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase)
5 LEU A 511
MET A 539
VAL A 504
LEU A 481
LEU A 479
None
1.32A 3b0wB-4bevA:
undetectable
3b0wB-4bevA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN


(Granulicella
tundricola)
PF07883
(Cupin_2)
5 ALA A 117
ALA A  40
VAL A  42
PHE A  19
HIS A  94
None
None
None
None
MN  A1132 (-3.6A)
1.24A 3b0wB-4bifA:
undetectable
3b0wB-4bifA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE


(Trypanosoma
brucei)
PF00206
(Lyase_1)
PF08328
(ASL_C)
5 ALA A 161
ALA A  36
LEU A 272
LEU A 336
HIS A 280
None
1.04A 3b0wB-4efcA:
undetectable
3b0wB-4efcA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN


(Chaetomium
thermophilum)
PF00012
(HSP70)
5 LEU A 146
ALA A 395
ALA A 142
VAL A 139
LEU A 169
None
1.20A 3b0wB-4gniA:
undetectable
3b0wB-4gniA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN


(Chaetomium
thermophilum)
PF00012
(HSP70)
5 LEU A 146
ALA A 398
ALA A 142
VAL A 139
LEU A 169
None
1.20A 3b0wB-4gniA:
undetectable
3b0wB-4gniA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE


(Wolinella
succinogenes)
PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C)
5 GLN A   6
LEU A 104
ALA A  17
MET A 352
ALA A 355
None
1.33A 3b0wB-4inaA:
undetectable
3b0wB-4inaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME


(Labrenzia
aggregata)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 CYH A  50
ALA A 303
ALA A 275
VAL A 269
LEU A  53
None
1.25A 3b0wB-4mggA:
undetectable
3b0wB-4mggA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae)
PF01522
(Polysacc_deac_1)
5 ALA A 260
VAL A 257
PHE A 318
LEU A 315
LEU A 247
None
0.92A 3b0wB-4nz5A:
undetectable
3b0wB-4nz5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE


(Ruegeria
pomeroyi)
PF03480
(DctP)
5 ALA A  44
MET A 261
ALA A 262
VAL A 142
LEU A  85
None
1.17A 3b0wB-4pafA:
undetectable
3b0wB-4pafA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE


(Ruegeria
pomeroyi)
PF03480
(DctP)
5 MET A 261
ALA A 262
VAL A 142
LEU A  77
LEU A  85
None
1.31A 3b0wB-4pafA:
undetectable
3b0wB-4pafA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis)
PF00294
(PfkB)
5 LEU A  66
ALA A 151
ALA A  50
VAL A  49
LEU A 174
None
None
None
HO4  A 401 (-4.5A)
None
1.28A 3b0wB-4pvvA:
undetectable
3b0wB-4pvvA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
5 GLN A 289
CYH A 323
ALA A 330
LEU A 394
HIS A 484
4D8  A 601 ( 2.7A)
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.5A)
None
0.98A 3b0wB-4s15A:
30.7
3b0wB-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
6 GLN A 289
LEU A 295
ALA A 330
ALA A 371
VAL A 379
LEU A 394
4D8  A 601 ( 2.7A)
None
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
1.36A 3b0wB-4s15A:
30.7
3b0wB-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
9 GLN A 289
LEU A 295
CYH A 323
ALA A 330
MET A 368
ALA A 371
VAL A 379
PHE A 391
LEU A 394
4D8  A 601 ( 2.7A)
None
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 (-4.0A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
4D8  A 601 ( 4.5A)
0.46A 3b0wB-4s15A:
30.7
3b0wB-4s15A:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5


(Mycobacterium
tuberculosis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A 268
CYH A 118
ALA A  41
VAL A  38
LEU A  30
None
1.34A 3b0wB-4ubtA:
undetectable
3b0wB-4ubtA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli)
PF00245
(Alk_phosphatase)
5 LEU A 120
ALA A 157
VAL A 160
LEU A 310
LEU A 255
None
1.22A 3b0wB-4yr1A:
undetectable
3b0wB-4yr1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum)
no annotation 5 LEU A 152
ALA A  59
ALA A  94
LEU A 166
LEU A 115
None
1.21A 3b0wB-5affA:
undetectable
3b0wB-5affA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE


(Homo sapiens)
PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C)
5 LEU A 242
ALA A 310
ALA A 345
VAL A 343
PHE A 290
None
1.26A 3b0wB-5c1bA:
undetectable
3b0wB-5c1bA:
15.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
10 GLN A 286
LEU A 292
CYH A 320
ALA A 327
MET A 365
ALA A 368
VAL A 376
PHE A 388
LEU A 391
LEU A 396
None
None
GOL  A 607 ( 4.0A)
None
None
None
None
GOL  A 607 ( 4.5A)
None
None
0.61A 3b0wB-5c4tA:
34.2
3b0wB-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
11 GLN A 286
LEU A 292
TRP A 317
CYH A 320
ALA A 327
ALA A 368
VAL A 376
PHE A 388
LEU A 391
LEU A 396
HIS A 479
None
None
None
GOL  A 607 ( 4.0A)
None
None
None
GOL  A 607 ( 4.5A)
None
None
None
0.52A 3b0wB-5c4tA:
34.2
3b0wB-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
6 LEU A 287
TRP A 317
PHE A 388
LEU A 391
LEU A 396
HIS A 479
None
None
GOL  A 607 ( 4.5A)
None
None
None
1.17A 3b0wB-5c4tA:
34.2
3b0wB-5c4tA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1


(Escherichia
coli)
no annotation 5 GLN D  90
ALA D  94
ALA D  50
VAL D  15
LEU D 272
None
1.07A 3b0wB-5dljD:
undetectable
3b0wB-5dljD:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euf PROTEASE

(Helicobacter
pylori)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
5 LEU A 330
VAL A 283
PHE A 432
LEU A 362
LEU A 424
None
1.26A 3b0wB-5eufA:
undetectable
3b0wB-5eufA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT


(Escherichia
coli)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 GLN C 287
LEU C 336
CYH C 696
ALA C 360
LEU C 401
None
ACT  C1740 ( 4.5A)
None
None
None
1.16A 3b0wB-5g5gC:
undetectable
3b0wB-5g5gC:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B


(Homo sapiens)
no annotation 5 LEU A 998
ALA A 958
MET A 940
ALA A 941
VAL A 991
None
1.25A 3b0wB-5hdtA:
undetectable
3b0wB-5hdtA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN


(Pseudomonas
syringae group
genomosp. 3)
no annotation 5 LEU A 231
CYH A 175
ALA A 181
VAL A 219
LEU A  94
None
1.28A 3b0wB-5iuwA:
undetectable
3b0wB-5iuwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48


(Homo sapiens)
PF00400
(WD40)
5 CYH B 109
ALA B 104
ALA B  48
VAL B  78
LEU B 113
None
1.15A 3b0wB-5k1cB:
undetectable
3b0wB-5k1cB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 LEU A 937
ALA A 587
VAL A 627
LEU A 596
LEU A 577
None
1.11A 3b0wB-5lstA:
undetectable
3b0wB-5lstA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb9 PUTATIVE HEAT SHOCK
PROTEIN


(Chaetomium
thermophilum)
PF00012
(HSP70)
5 LEU A 146
ALA A 395
ALA A 142
VAL A 139
LEU A 169
None
1.24A 3b0wB-5mb9A:
undetectable
3b0wB-5mb9A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC


(Pseudomonas
protegens)
no annotation 5 CYH C 112
ALA C  34
MET C  43
ALA C  41
VAL C   9
None
1.29A 3b0wB-5mg5C:
undetectable
3b0wB-5mg5C:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1


(Arabidopsis
thaliana)
no annotation 5 LEU A1264
ALA A1236
VAL A1219
LEU A1186
LEU A1197
None
1.15A 3b0wB-5wblA:
undetectable
3b0wB-5wblA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE


(Malbranchea
aurantiaca)
PF04820
(Trp_halogenase)
5 LEU A 382
ALA A 230
VAL A 324
PHE A 259
LEU A 116
FAD  A 701 ( 4.7A)
FAD  A 701 (-3.6A)
None
None
None
1.35A 3b0wB-5wgxA:
undetectable
3b0wB-5wgxA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]


(Aliivibrio
fischeri)
no annotation 5 LEU A 129
ALA A  98
VAL A  44
PHE A 312
LEU A 309
None
1.08A 3b0wB-5xi0A:
undetectable
3b0wB-5xi0A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN


(Chaetomium
thermophilum)
no annotation 5 LEU H 258
ALA H 326
ALA H 361
VAL H 359
PHE H 306
None
1.24A 3b0wB-6chsH:
undetectable
3b0wB-6chsH:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE


(Methanothermococcus
thermolithotrophicus)
no annotation 5 LEU A  73
ALA A 215
ALA A  71
PHE A  22
LEU A  17
None
1.15A 3b0wB-6et9A:
undetectable
3b0wB-6et9A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE


(Bacteroides
thetaiotaomicron)
no annotation 5 LEU A 621
MET A 650
ALA A 649
VAL A 646
LEU A 676
None
1.26A 3b0wB-6f8zA:
undetectable
3b0wB-6f8zA:
15.00