SIMILAR PATTERNS OF AMINO ACIDS FOR 3B0W_B_DGXB1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a05 3-ISOPROPYLMALATE
DEHYDROGENASE

(Acidithiobacillus
ferrooxidans) 		PF00180
(Iso_dh) 		5 GLN A  22
LEU A 354
ALA A  19
VAL A 320
HIS A 278
 None
 1.25A 3b0wB-1a05A:
0.0		 3b0wB-1a05A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 CYH A 344
ALA A 368
ALA A 417
LEU A 362
LEU A 302
 None
 1.36A 3b0wB-1cj0A:
0.6		 3b0wB-1cj0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		5 GLN A  10
LEU A 315
CYH A  51
ALA A  48
ALA A 314
 None
None
ZN  A1001 (-2.3A)
None
None
 1.31A 3b0wB-1fn9A:
0.0		 3b0wB-1fn9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ftg APOFLAVODOXIN

(Nostoc sp. PCC
7119) 		PF00258
(Flavodoxin_1) 		5 LEU A 163
CYH A  54
ALA A  19
LEU A  62
LEU A  69
 None
 1.32A 3b0wB-1ftgA:
undetectable		 3b0wB-1ftgA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		5 LEU L 134
MET L 105
ALA L 104
LEU L 242
LEU L 246
 None
 1.09A 3b0wB-1hfeL:
undetectable		 3b0wB-1hfeL:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igw ISOCITRATE LYASE

(Escherichia
coli) 		PF00463
(ICL) 		5 LEU A 229
ALA A 209
ALA A 283
VAL A 286
PHE A 301
 None
 1.21A 3b0wB-1igwA:
0.0		 3b0wB-1igwA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 LEU A  41
CYH A  74
ALA A 138
ALA A  56
VAL A  58
 None
 1.03A 3b0wB-1k8gA:
0.0		 3b0wB-1k8gA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 GLN A 230
LEU A 259
ALA A 255
VAL A 254
LEU A 185
 None
 1.09A 3b0wB-1krhA:
undetectable		 3b0wB-1krhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrt INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH) 		5 GLN A  84
LEU A 250
ALA A 236
VAL A 234
LEU A 443
 None
 1.29A 3b0wB-1lrtA:
0.0		 3b0wB-1lrtA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Tritrichomonas
suis) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 GLN A  84
LEU A 250
ALA A 236
VAL A 234
LEU A 443
 None
 1.33A 3b0wB-1mewA:
undetectable		 3b0wB-1mewA:
17.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		5 GLN A 228
CYH A 262
ALA A 269
LEU A 333
HIS A 423
 ARL  A 800 (-4.7A)
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
None
ARL  A 800 ( 4.3A)
 1.16A 3b0wB-1nq7A:
28.9		 3b0wB-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		10 GLN A 228
LEU A 234
CYH A 262
ALA A 269
MET A 307
ALA A 310
VAL A 318
PHE A 330
LEU A 333
LEU A 338
 ARL  A 800 (-4.7A)
None
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
ARL  A 800 (-3.7A)
ARL  A 800 ( 4.1A)
None
ARL  A 800 (-3.6A)
None
ARL  A 800 ( 4.8A)
 0.83A 3b0wB-1nq7A:
28.9		 3b0wB-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		6 GLN A 228
LEU A 237
CYH A 262
PHE A 330
LEU A 333
LEU A 338
 ARL  A 800 (-4.7A)
None
ARL  A 800 (-3.5A)
ARL  A 800 (-3.6A)
None
ARL  A 800 ( 4.8A)
 1.23A 3b0wB-1nq7A:
28.9		 3b0wB-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		8 LEU A 234
CYH A 262
ALA A 269
MET A 307
ALA A 310
VAL A 318
PHE A 330
LEU A 258
 None
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
ARL  A 800 (-3.7A)
ARL  A 800 ( 4.1A)
None
ARL  A 800 (-3.6A)
None
 1.50A 3b0wB-1nq7A:
28.9		 3b0wB-1nq7A:
49.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 GLN B   8
CYH C 144
VAL C  37
PHE C  51
LEU C 146
 None
 1.32A 3b0wB-1sxjB:
undetectable		 3b0wB-1sxjB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		5 LEU A 409
CYH A 356
ALA A 339
VAL A 383
LEU A 448
 None
 1.26A 3b0wB-1tdjA:
undetectable		 3b0wB-1tdjA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txz HYPOTHETICAL 32.1
KDA PROTEIN IN
ADH3-RCA1 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF14519
(Macro_2) 		5 LEU A 188
ALA A 120
MET A 179
PHE A 171
LEU A 235
 None
 1.32A 3b0wB-1txzA:
undetectable		 3b0wB-1txzA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		5 CYH A 194
MET A 300
ALA A 304
VAL A 308
LEU A 232
 None
 1.29A 3b0wB-1v02A:
undetectable		 3b0wB-1v02A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		5 LEU A 123
MET A 150
ALA A 153
VAL A 160
LEU A 180
 None
 1.31A 3b0wB-1v19A:
undetectable		 3b0wB-1v19A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		5 GLN A 110
LEU A 163
ALA A 167
PHE A  54
LEU A 191
 None
 1.30A 3b0wB-1v8dA:
undetectable		 3b0wB-1v8dA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		5 LEU A 346
ALA A 422
MET A 227
VAL A 427
LEU A 401
 None
 1.14A 3b0wB-1vl4A:
undetectable		 3b0wB-1vl4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vm7 RIBOKINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 ALA A 244
ALA A 238
VAL A 236
PHE A 295
LEU A 296
 None
 1.23A 3b0wB-1vm7A:
undetectable		 3b0wB-1vm7A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		5 MET A 423
ALA A 428
VAL A 351
PHE A 241
LEU A 378
 None
 1.29A 3b0wB-1ytmA:
undetectable		 3b0wB-1ytmA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		5 LEU A 415
VAL A 395
LEU A 487
LEU A 473
HIS A 468
 None
 1.35A 3b0wB-1z6tA:
undetectable		 3b0wB-1z6tA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 708
ALA A 630
ALA A 667
PHE A 511
LEU A 508
 None
 1.29A 3b0wB-1zcjA:
undetectable		 3b0wB-1zcjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 LEU A 199
MET A 182
ALA A 184
LEU A 273
LEU A 294
 None
 1.36A 3b0wB-2bb0A:
undetectable		 3b0wB-2bb0A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 GLN A 228
LEU A 222
ALA A 172
VAL A 174
LEU A 111
 None
 1.27A 3b0wB-2cb1A:
undetectable		 3b0wB-2cb1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 175
ALA A  62
ALA A 200
VAL A 202
LEU A 223
 None
 1.35A 3b0wB-2eq9A:
undetectable		 3b0wB-2eq9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb4 THIOPURINE
S-METHYLTRANSFERASE

(Mus musculus) 		PF05724
(TPMT) 		5 LEU A 230
CYH A 211
ALA A 178
ALA A 217
HIS A  47
 None
 1.24A 3b0wB-2gb4A:
undetectable		 3b0wB-2gb4A:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnw NON-SYMBIOTIC
HEMOGLOBIN 1

(Oryza sativa) 		PF00042
(Globin) 		5 GLN A  87
LEU A 101
ALA A 156
VAL A 154
LEU A 126
 None
None
None
HEM  A 166 (-4.4A)
None
 1.29A 3b0wB-2gnwA:
undetectable		 3b0wB-2gnwA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		5 ALA A 786
ALA A 918
VAL A1015
PHE A 991
LEU A 930
 None
 1.33A 3b0wB-2j7nA:
undetectable		 3b0wB-2j7nA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvu ARTJ

(Geobacillus
stearothermophilus) 		PF00497
(SBP_bac_3) 		5 MET A  54
ALA A 222
VAL A 219
PHE A 209
LEU A  75
 None
 1.16A 3b0wB-2pvuA:
undetectable		 3b0wB-2pvuA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5v PCZA361.1

(Amycolatopsis
orientalis) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		5 LEU A  52
ALA A 243
VAL A  75
PHE A 119
LEU A 166
 None
CO  A4113 ( 4.4A)
None
None
None
 1.34A 3b0wB-2r5vA:
undetectable		 3b0wB-2r5vA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens) 		PF06418
(CTP_synth_N) 		5 LEU A 130
ALA A 129
VAL A 125
PHE A 163
LEU A 209
 None
 1.28A 3b0wB-2vo1A:
undetectable		 3b0wB-2vo1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  97
ALA A  67
ALA A  60
PHE A 114
LEU A 306
 None
 1.30A 3b0wB-2x3eA:
undetectable		 3b0wB-2x3eA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		5 LEU A 407
ALA A 490
ALA A 510
VAL A 451
PHE A 464
 None
 1.30A 3b0wB-2yjqA:
undetectable		 3b0wB-2yjqA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		5 LEU A 222
ALA A 244
ALA A 252
VAL A 229
LEU A  87
 None
 1.22A 3b0wB-2zieA:
undetectable		 3b0wB-2zieA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A  20
CYH A 401
ALA A 381
VAL A 387
PHE A 337
 None
 1.23A 3b0wB-3aatA:
undetectable		 3b0wB-3aatA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahr ERO1-LIKE PROTEIN
ALPHA

(Homo sapiens) 		PF04137
(ERO1) 		5 LEU A 415
ALA A 446
ALA A 314
VAL A 318
LEU A 329
 None
 1.28A 3b0wB-3ahrA:
undetectable		 3b0wB-3ahrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		5 LEU A 325
ALA A  14
ALA A 284
VAL A 286
LEU A 113
 None
 1.23A 3b0wB-3allA:
undetectable		 3b0wB-3allA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 TRP A 110
ALA A 168
ALA A 152
VAL A 154
LEU A  94
 None
 1.05A 3b0wB-3b4wA:
undetectable		 3b0wB-3b4wA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 520
ALA A 626
VAL A 624
PHE A 568
LEU A 470
 None
 1.17A 3b0wB-3b9pA:
undetectable		 3b0wB-3b9pA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crr TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF01715
(IPPT) 		5 GLN A 288
LEU A 216
ALA A  15
LEU A  33
LEU A  57
 TRS  A 327 ( 4.9A)
None
DPO  A 326 (-4.6A)
None
None
 1.30A 3b0wB-3crrA:
undetectable		 3b0wB-3crrA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		5 GLN A 406
ALA A 403
ALA A 316
PHE A 289
HIS A 279
 None
 1.19A 3b0wB-3dc8A:
undetectable		 3b0wB-3dc8A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5b ISOCITRATE LYASE

(Brucella
abortus) 		PF00463
(ICL) 		5 LEU A 203
ALA A 221
VAL A 220
PHE A 341
LEU A 332
 None
 1.33A 3b0wB-3e5bA:
undetectable		 3b0wB-3e5bA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9n PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Corynebacterium
glutamicum) 		PF00106
(adh_short) 		5 LEU A  42
ALA A  80
ALA A  31
VAL A  29
LEU A 119
 None
 1.21A 3b0wB-3e9nA:
undetectable		 3b0wB-3e9nA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02820
(MBT) 		5 CYH A 303
ALA A 243
VAL A 245
PHE A 285
LEU A 281
 None
 1.32A 3b0wB-3feoA:
undetectable		 3b0wB-3feoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gjb CYTC3

(Streptomyces
sp.) 		PF05721
(PhyH) 		5 LEU A 226
ALA A 258
ALA A 231
VAL A  29
PHE A  12
 None
 1.36A 3b0wB-3gjbA:
undetectable		 3b0wB-3gjbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqj CELL INHIBITING
FACTOR (CIF)

(Photorhabdus
laumondii) 		PF16374
(CIF) 		5 LEU A 278
ALA A 172
VAL A 174
LEU A 208
LEU A 211
 None
 1.08A 3b0wB-3gqjA:
undetectable		 3b0wB-3gqjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1

(Mycobacterium
tuberculosis) 		PF00464
(SHMT) 		5 ALA A 218
VAL A 197
PHE A 202
LEU A 205
LEU A 229
 None
 1.36A 3b0wB-3h7fA:
undetectable		 3b0wB-3h7fA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 LEU A 165
MET A 132
ALA A 131
VAL A 365
LEU A 327
 None
 1.35A 3b0wB-3i45A:
undetectable		 3b0wB-3i45A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 324
TRP A 169
MET A 276
ALA A 275
LEU A  67
 None
 1.18A 3b0wB-3i8bA:
undetectable		 3b0wB-3i8bA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		5 LEU A 558
ALA A 557
VAL A 553
LEU A  88
LEU A  67
 None
 1.29A 3b0wB-3iukA:
undetectable		 3b0wB-3iukA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		5 GLN A  31
MET A  24
ALA A  25
VAL A  14
HIS A 143
 None
 1.31A 3b0wB-3l6dA:
undetectable		 3b0wB-3l6dA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg3 ISOCITRATE LYASE

(Yersinia pestis) 		PF00463
(ICL) 		5 LEU A 230
ALA A 210
ALA A 284
VAL A 287
PHE A 302
 None
 1.13A 3b0wB-3lg3A:
undetectable		 3b0wB-3lg3A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhq ACRAB OPERON
REPRESSOR (TETR/ACRR
FAMILY)

(Salmonella
enterica) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		5 ALA A 129
VAL A 126
PHE A  59
LEU A  21
LEU A  17
 None
 1.29A 3b0wB-3lhqA:
undetectable		 3b0wB-3lhqA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD

(Bacillus
subtilis) 		PF07451
(SpoVAD) 		5 LEU A  81
ALA A 185
VAL A 171
PHE A 291
LEU A 294
 None
 1.24A 3b0wB-3lm6A:
undetectable		 3b0wB-3lm6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3men ACETYLPOLYAMINE
AMINOHYDROLASE

(Burkholderia
pseudomallei) 		PF00850
(Hist_deacetyl) 		5 GLN A   9
CYH A 167
ALA A 149
VAL A 315
HIS A  62
 None
SO4  A 401 ( 4.2A)
None
None
None
 1.14A 3b0wB-3menA:
undetectable		 3b0wB-3menA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN

(Homo sapiens) 		PF01463
(LRRCT) 		5 TRP A  21
ALA A  52
VAL A  12
LEU A  42
LEU A  61
 None
 1.30A 3b0wB-3rfeA:
undetectable		 3b0wB-3rfeA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 LEU A 448
ALA A 463
VAL A 511
LEU A 560
LEU A 540
 None
 1.35A 3b0wB-3s1sA:
undetectable		 3b0wB-3s1sA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx7 CHITIN
OLIGOSACCHARIDE
DEACETYLASE

(Vibrio
parahaemolyticus) 		PF01522
(Polysacc_deac_1) 		5 ALA A 256
VAL A 253
PHE A 314
LEU A 311
LEU A 243
 None
 0.91A 3b0wB-3wx7A:
undetectable		 3b0wB-3wx7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx ACRH
AOPB

(Aeromonas
hydrophila) 		PF04888
(SseC)
no annotation 		5 ALA B 235
ALA B 178
VAL B 175
LEU A  74
LEU A  86
 None
 1.31A 3b0wB-3wxxB:
undetectable		 3b0wB-3wxxB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 LEU A 378
ALA A 255
ALA A 342
VAL A 341
PHE A 192
 None
 1.18A 3b0wB-4anjA:
undetectable		 3b0wB-4anjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		5 LEU D 171
ALA D 136
ALA D 168
LEU D 152
HIS D 145
 None
 1.33A 3b0wB-4b8cD:
undetectable		 3b0wB-4b8cD:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bev COPPER EFFLUX ATPASE

(Legionella
pneumophila) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 LEU A 511
MET A 539
VAL A 504
LEU A 481
LEU A 479
 None
 1.32A 3b0wB-4bevA:
undetectable		 3b0wB-4bevA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		5 ALA A 117
ALA A  40
VAL A  42
PHE A  19
HIS A  94
 None
None
None
None
MN  A1132 (-3.6A)
 1.24A 3b0wB-4bifA:
undetectable		 3b0wB-4bifA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efc ADENYLOSUCCINATE
LYASE

(Trypanosoma
brucei) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 ALA A 161
ALA A  36
LEU A 272
LEU A 336
HIS A 280
 None
 1.04A 3b0wB-4efcA:
undetectable		 3b0wB-4efcA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 LEU A 146
ALA A 395
ALA A 142
VAL A 139
LEU A 169
 None
 1.20A 3b0wB-4gniA:
undetectable		 3b0wB-4gniA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 LEU A 146
ALA A 398
ALA A 142
VAL A 139
LEU A 169
 None
 1.20A 3b0wB-4gniA:
undetectable		 3b0wB-4gniA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 GLN A   6
LEU A 104
ALA A  17
MET A 352
ALA A 355
 None
 1.33A 3b0wB-4inaA:
undetectable		 3b0wB-4inaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 CYH A  50
ALA A 303
ALA A 275
VAL A 269
LEU A  53
 None
 1.25A 3b0wB-4mggA:
undetectable		 3b0wB-4mggA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		5 ALA A 260
VAL A 257
PHE A 318
LEU A 315
LEU A 247
 None
 0.92A 3b0wB-4nz5A:
undetectable		 3b0wB-4nz5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		5 ALA A  44
MET A 261
ALA A 262
VAL A 142
LEU A  85
 None
 1.17A 3b0wB-4pafA:
undetectable		 3b0wB-4pafA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		5 MET A 261
ALA A 262
VAL A 142
LEU A  77
LEU A  85
 None
 1.31A 3b0wB-4pafA:
undetectable		 3b0wB-4pafA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 LEU A  66
ALA A 151
ALA A  50
VAL A  49
LEU A 174
 None
None
None
HO4  A 401 (-4.5A)
None
 1.28A 3b0wB-4pvvA:
undetectable		 3b0wB-4pvvA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLN A 289
CYH A 323
ALA A 330
LEU A 394
HIS A 484
 4D8  A 601 ( 2.7A)
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.5A)
None
 0.98A 3b0wB-4s15A:
30.7		 3b0wB-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLN A 289
LEU A 295
ALA A 330
ALA A 371
VAL A 379
LEU A 394
 4D8  A 601 ( 2.7A)
None
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
 1.36A 3b0wB-4s15A:
30.7		 3b0wB-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 GLN A 289
LEU A 295
CYH A 323
ALA A 330
MET A 368
ALA A 371
VAL A 379
PHE A 391
LEU A 394
 4D8  A 601 ( 2.7A)
None
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 (-4.0A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
4D8  A 601 ( 4.5A)
 0.46A 3b0wB-4s15A:
30.7		 3b0wB-4s15A:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubt ACETYL-COA
ACETYLTRANSFERASE
FADA5

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 268
CYH A 118
ALA A  41
VAL A  38
LEU A  30
 None
 1.34A 3b0wB-4ubtA:
undetectable		 3b0wB-4ubtA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		5 LEU A 120
ALA A 157
VAL A 160
LEU A 310
LEU A 255
 None
 1.22A 3b0wB-4yr1A:
undetectable		 3b0wB-4yr1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 LEU A 152
ALA A  59
ALA A  94
LEU A 166
LEU A 115
 None
 1.21A 3b0wB-5affA:
undetectable		 3b0wB-5affA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 LEU A 242
ALA A 310
ALA A 345
VAL A 343
PHE A 290
 None
 1.26A 3b0wB-5c1bA:
undetectable		 3b0wB-5c1bA:
15.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 GLN A 286
LEU A 292
CYH A 320
ALA A 327
MET A 365
ALA A 368
VAL A 376
PHE A 388
LEU A 391
LEU A 396
 None
None
GOL  A 607 ( 4.0A)
None
None
None
None
GOL  A 607 ( 4.5A)
None
None
 0.61A 3b0wB-5c4tA:
34.2		 3b0wB-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 GLN A 286
LEU A 292
TRP A 317
CYH A 320
ALA A 327
ALA A 368
VAL A 376
PHE A 388
LEU A 391
LEU A 396
HIS A 479
 None
None
None
GOL  A 607 ( 4.0A)
None
None
None
GOL  A 607 ( 4.5A)
None
None
None
 0.52A 3b0wB-5c4tA:
34.2		 3b0wB-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 287
TRP A 317
PHE A 388
LEU A 391
LEU A 396
HIS A 479
 None
None
GOL  A 607 ( 4.5A)
None
None
None
 1.17A 3b0wB-5c4tA:
34.2		 3b0wB-5c4tA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Escherichia
coli) 		no annotation 5 GLN D  90
ALA D  94
ALA D  50
VAL D  15
LEU D 272
 None
 1.07A 3b0wB-5dljD:
undetectable		 3b0wB-5dljD:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euf PROTEASE

(Helicobacter
pylori) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 330
VAL A 283
PHE A 432
LEU A 362
LEU A 424
 None
 1.26A 3b0wB-5eufA:
undetectable		 3b0wB-5eufA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLN C 287
LEU C 336
CYH C 696
ALA C 360
LEU C 401
 None
ACT  C1740 ( 4.5A)
None
None
None
 1.16A 3b0wB-5g5gC:
undetectable		 3b0wB-5g5gC:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 LEU A 998
ALA A 958
MET A 940
ALA A 941
VAL A 991
 None
 1.25A 3b0wB-5hdtA:
undetectable		 3b0wB-5hdtA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 LEU A 231
CYH A 175
ALA A 181
VAL A 219
LEU A  94
 None
 1.28A 3b0wB-5iuwA:
undetectable		 3b0wB-5iuwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 CYH B 109
ALA B 104
ALA B  48
VAL B  78
LEU B 113
 None
 1.15A 3b0wB-5k1cB:
undetectable		 3b0wB-5k1cB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 937
ALA A 587
VAL A 627
LEU A 596
LEU A 577
 None
 1.11A 3b0wB-5lstA:
undetectable		 3b0wB-5lstA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb9 PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 LEU A 146
ALA A 395
ALA A 142
VAL A 139
LEU A 169
 None
 1.24A 3b0wB-5mb9A:
undetectable		 3b0wB-5mb9A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 5 CYH C 112
ALA C  34
MET C  43
ALA C  41
VAL C   9
 None
 1.29A 3b0wB-5mg5C:
undetectable		 3b0wB-5mg5C:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 5 LEU A1264
ALA A1236
VAL A1219
LEU A1186
LEU A1197
 None
 1.15A 3b0wB-5wblA:
undetectable		 3b0wB-5wblA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		5 LEU A 382
ALA A 230
VAL A 324
PHE A 259
LEU A 116
 FAD  A 701 ( 4.7A)
FAD  A 701 (-3.6A)
None
None
None
 1.35A 3b0wB-5wgxA:
undetectable		 3b0wB-5wgxA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aliivibrio
fischeri) 		no annotation 5 LEU A 129
ALA A  98
VAL A  44
PHE A 312
LEU A 309
 None
 1.08A 3b0wB-5xi0A:
undetectable		 3b0wB-5xi0A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 LEU H 258
ALA H 326
ALA H 361
VAL H 359
PHE H 306
 None
 1.24A 3b0wB-6chsH:
undetectable		 3b0wB-6chsH:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 LEU A  73
ALA A 215
ALA A  71
PHE A  22
LEU A  17
 None
 1.15A 3b0wB-6et9A:
undetectable		 3b0wB-6et9A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 621
MET A 650
ALA A 649
VAL A 646
LEU A 676
 None
 1.26A 3b0wB-6f8zA:
undetectable		 3b0wB-6f8zA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atj PEROXIDASE C1A

(Armoracia
rusticana) 		PF00141
(peroxidase) 		3 LEU A  54
VAL A  95
ARG A 298
 None
 0.81A 3b0wB-1atjA:
0.0		 3b0wB-1atjA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		3 LEU A  61
VAL A 104
ARG A 298
 None
 0.89A 3b0wB-1bgpA:
0.2		 3b0wB-1bgpA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)

(Rattus
norvegicus) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 LEU A   8
VAL A 157
ARG A 164
 None
 0.60A 3b0wB-1bu8A:
0.0		 3b0wB-1bu8A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekz MATERNAL EFFECT
PROTEIN (STAUFEN)

(Drosophila
melanogaster) 		PF00035
(dsrm) 		3 LEU A  76
VAL A  13
ARG A  20
 None
 0.78A 3b0wB-1ekzA:
undetectable		 3b0wB-1ekzA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		3 LEU A 185
VAL A  42
ARG A 115
 None
 0.90A 3b0wB-1gk2A:
0.0		 3b0wB-1gk2A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		3 LEU A 167
VAL A 185
ARG A 191
 None
 0.81A 3b0wB-1i9gA:
0.0		 3b0wB-1i9gA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		3 LEU A 157
VAL A 202
ARG A 205
 None
None
CL  A 505 (-3.9A)
 0.38A 3b0wB-1icpA:
0.0		 3b0wB-1icpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcw CERULOPLASMIN

(Homo sapiens) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 LEU A 786
VAL A 777
ARG A 766
 None
 0.87A 3b0wB-1kcwA:
0.0		 3b0wB-1kcwA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mq7 DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Mycobacterium
tuberculosis) 		PF00692
(dUTPase) 		3 LEU A  10
VAL A  92
ARG A  46
 None
 0.90A 3b0wB-1mq7A:
0.0		 3b0wB-1mq7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzv ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leishmania
tarentolae) 		PF00156
(Pribosyltran) 		3 LEU A 209
VAL A  39
ARG A  41
 None
 0.83A 3b0wB-1mzvA:
undetectable		 3b0wB-1mzvA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 LEU A 436
VAL A 387
ARG A 391
 None
 0.86A 3b0wB-1p43A:
undetectable		 3b0wB-1p43A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leishmania
donovani) 		PF00156
(Pribosyltran) 		3 LEU A 209
VAL A  39
ARG A  41
 None
 0.87A 3b0wB-1qcdA:
undetectable		 3b0wB-1qcdA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		3 LEU 1 223
VAL 1 334
ARG 1 371
 None
 0.56A 3b0wB-1wao1:
undetectable		 3b0wB-1wao1:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		3 LEU B2100
VAL B2123
ARG B2126
 None
 0.78A 3b0wB-2assB:
undetectable		 3b0wB-2assB:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		3 LEU A  55
VAL A  77
ARG A  80
 None
 0.82A 3b0wB-2b3bA:
undetectable		 3b0wB-2b3bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		3 LEU A 102
VAL A  63
ARG A  12
 None
 0.73A 3b0wB-2bwsA:
undetectable		 3b0wB-2bwsA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		3 LEU A 691
VAL A 537
ARG A 740
 None
 0.90A 3b0wB-2c4mA:
undetectable		 3b0wB-2c4mA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef0 ORNITHINE
CARBAMOYLTRANSFERASE

(Thermus
thermophilus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LEU A 212
VAL A 160
ARG A 182
 None
 0.80A 3b0wB-2ef0A:
undetectable		 3b0wB-2ef0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd5 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		3 LEU A  63
VAL A 132
ARG A  67
 None
 0.90A 3b0wB-2fd5A:
undetectable		 3b0wB-2fd5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdq YITF

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 260
VAL A 237
ARG A 232
 None
 0.85A 3b0wB-2gdqA:
undetectable		 3b0wB-2gdqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		3 LEU A 120
VAL A  92
ARG A  90
 None
 0.84A 3b0wB-2go7A:
undetectable		 3b0wB-2go7A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoq PUTATIVE
HAD-HYDROLASE PH1655

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		3 LEU A 131
VAL A 102
ARG A 100
 None
 0.85A 3b0wB-2hoqA:
undetectable		 3b0wB-2hoqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jy6 UBIQUILIN-1

(Homo sapiens) 		PF00627
(UBA) 		3 LEU B 554
VAL B 545
ARG B 562
 None
 0.81A 3b0wB-2jy6B:
undetectable		 3b0wB-2jy6B:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		3 LEU A  41
VAL A  33
ARG A  38
 None
 0.68A 3b0wB-2ogaA:
undetectable		 3b0wB-2ogaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pag HYPOTHETICAL PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14567
(SUKH_5) 		3 LEU A  34
VAL A  83
ARG A  85
 None
 0.75A 3b0wB-2pagA:
undetectable		 3b0wB-2pagA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1

(Arabidopsis
thaliana) 		PF00724
(Oxidored_FMN) 		3 LEU A 153
VAL A 198
ARG A 201
 None
 0.60A 3b0wB-2q3rA:
undetectable		 3b0wB-2q3rA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		3 LEU A 120
VAL A 253
ARG A 251
 None
 0.84A 3b0wB-2q9gA:
undetectable		 3b0wB-2q9gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtv SMALL COPII COAT
GTPASE SAR1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		3 LEU B 122
VAL B 128
ARG B 164
 None
 0.89A 3b0wB-2qtvB:
undetectable		 3b0wB-2qtvB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vac TWINFILIN-2

(Homo sapiens) 		PF00241
(Cofilin_ADF) 		3 LEU A  73
VAL A  57
ARG A  26
 None
 0.83A 3b0wB-2vacA:
undetectable		 3b0wB-2vacA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6l COBE

(Pseudomonas
aeruginosa) 		PF01890
(CbiG_C) 		3 LEU A  39
VAL A  68
ARG A  66
 None
 0.81A 3b0wB-2w6lA:
undetectable		 3b0wB-2w6lA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		3 LEU A 659
VAL A 706
ARG A 656
 None
 0.87A 3b0wB-2x24A:
undetectable		 3b0wB-2x24A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa0 APOPTOSIS REGULATOR
BCL-2

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		3 LEU A 119
VAL A 162
ARG A 164
 None
 0.83A 3b0wB-2xa0A:
undetectable		 3b0wB-2xa0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4r 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Pseudomonas
aeruginosa) 		PF01063
(Aminotran_4) 		3 LEU A 183
VAL A 171
ARG A 219
 None
 0.90A 3b0wB-2y4rA:
undetectable		 3b0wB-2y4rA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		3 LEU A 100
VAL A 123
ARG A 129
 None
 0.73A 3b0wB-2yr0A:
undetectable		 3b0wB-2yr0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE

(Pseudomonas
putida) 		PF00202
(Aminotran_3) 		3 LEU X  56
VAL X 261
ARG X 267
 None
PLP  X 450 (-4.2A)
None
 0.85A 3b0wB-3a8uX:
undetectable		 3b0wB-3a8uX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 LEU A 690
VAL A 716
ARG A 723
 None
 0.70A 3b0wB-3ai7A:
undetectable		 3b0wB-3ai7A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF08241
(Methyltransf_11) 		3 LEU A 116
VAL A 193
ARG A 191
 None
None
EDO  A 243 ( 3.8A)
 0.74A 3b0wB-3bkwA:
undetectable		 3b0wB-3bkwA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8v PUTATIVE
ACETYLTRANSFERASE

(Desulfovibrio
alaskensis) 		no annotation 3 LEU A 204
VAL A 401
ARG A 409
 None
None
EDO  A 485 (-4.0A)
 0.81A 3b0wB-3c8vA:
undetectable		 3b0wB-3c8vA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ci0 PSEUDOPILIN GSPK

(Escherichia
coli) 		PF03934
(T2SSK) 		3 LEU K 211
VAL K  65
ARG K 239
 None
 0.67A 3b0wB-3ci0K:
undetectable		 3b0wB-3ci0K:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		3 LEU A 325
VAL A 332
ARG A 261
 None
 0.89A 3b0wB-3da1A:
undetectable		 3b0wB-3da1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LEU A 321
VAL A 354
ARG A 135
 None
 0.74A 3b0wB-3fj4A:
undetectable		 3b0wB-3fj4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		3 LEU A 113
VAL A   6
ARG A   3
 None
 0.72A 3b0wB-3g5sA:
undetectable		 3b0wB-3g5sA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		3 LEU A 223
VAL A 334
ARG A 371
 None
 0.73A 3b0wB-3h68A:
undetectable		 3b0wB-3h68A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib7 ICC PROTEIN

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		3 LEU A 109
VAL A  80
ARG A  77
 MPD  A 779 ( 4.7A)
None
None
 0.80A 3b0wB-3ib7A:
undetectable		 3b0wB-3ib7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri) 		PF00936
(BMC) 		3 LEU A 278
VAL A 188
ARG A 282
 None
 0.73A 3b0wB-3io0A:
undetectable		 3b0wB-3io0A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9f POLIOVIRUS RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		3 LEU 7 103
VAL 7  31
ARG 7 104
 None
 0.75A 3b0wB-3j9f7:
undetectable		 3b0wB-3j9f7:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvv TWITCHING MOBILITY
PROTEIN

(Pseudomonas
aeruginosa) 		PF00437
(T2SSE) 		3 LEU A 311
VAL A 121
ARG A 117
 None
 0.86A 3b0wB-3jvvA:
undetectable		 3b0wB-3jvvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		3 LEU A 188
VAL A 245
ARG A 247
 None
 0.78A 3b0wB-3kswA:
undetectable		 3b0wB-3kswA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m65 ATP-DEPENDENT
PROTEASE LA 1

(Bacillus
subtilis) 		PF02190
(LON_substr_bdg) 		3 LEU A  89
VAL A  29
ARG A  87
 None
 0.91A 3b0wB-3m65A:
undetectable		 3b0wB-3m65A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		3 LEU A 136
VAL A 191
ARG A 132
 None
 0.80A 3b0wB-3m99A:
undetectable		 3b0wB-3m99A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		3 LEU K 402
VAL K  88
ARG K  38
 None
 0.87A 3b0wB-3mvdK:
undetectable		 3b0wB-3mvdK:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbi RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1

(Homo sapiens) 		PF08585
(RMI1_N) 		3 LEU A 157
VAL A  95
ARG A 133
 None
 0.63A 3b0wB-3nbiA:
undetectable		 3b0wB-3nbiA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwa ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		no annotation 3 LEU B 330
VAL B 276
ARG B 245
 None
 0.70A 3b0wB-3nwaB:
undetectable		 3b0wB-3nwaB:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2r GLIOMA
PATHOGENESIS-RELATED
PROTEIN 1

(Homo sapiens) 		PF00188
(CAP) 		3 LEU A  56
VAL A  38
ARG A  45
 None
 0.91A 3b0wB-3q2rA:
undetectable		 3b0wB-3q2rA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy3 THIOESTERASE

(Pseudomonas
aeruginosa) 		PF13279
(4HBT_2) 		3 LEU A  34
VAL A  90
ARG A  38
 None
 0.71A 3b0wB-3qy3A:
undetectable		 3b0wB-3qy3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 LEU A 406
VAL A 314
ARG A 319
 None
 0.88A 3b0wB-3rr5A:
undetectable		 3b0wB-3rr5A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		3 LEU A 111
VAL A  72
ARG A  70
 None
 0.84A 3b0wB-3se7A:
undetectable		 3b0wB-3se7A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		3 LEU A 105
VAL A 122
ARG A 156
 None
 0.64A 3b0wB-3t57A:
undetectable		 3b0wB-3t57A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tat TYROSINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 LEU A 248
VAL A 272
ARG A  99
 None
 0.86A 3b0wB-3tatA:
undetectable		 3b0wB-3tatA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		3 LEU A 341
VAL A 371
ARG A 140
 None
 0.84A 3b0wB-3va8A:
undetectable		 3b0wB-3va8A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdg PROBABLE GLUCARATE
DEHYDRATASE

(Mycolicibacterium
smegmatis) 		PF13378
(MR_MLE_C) 		3 LEU A 343
VAL A 371
ARG A 142
 None
 0.81A 3b0wB-3vdgA:
undetectable		 3b0wB-3vdgA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8x POSSIBLE
MARR-TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF12802
(MarR_2) 		3 LEU A  66
VAL A 126
ARG A 124
 None
 0.84A 3b0wB-4b8xA:
undetectable		 3b0wB-4b8xA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		3 LEU A  57
VAL A 261
ARG A 267
 None
PXG  A 470 (-4.0A)
None
 0.88A 3b0wB-4b98A:
undetectable		 3b0wB-4b98A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SAR1P

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		3 LEU B 122
VAL B 128
ARG B 164
 None
 0.89A 3b0wB-4bziB:
undetectable		 3b0wB-4bziB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuo BANYAN PEROXIDASE

(Ficus
benghalensis) 		PF00141
(peroxidase) 		3 LEU A  54
VAL A  95
ARG A 296
 None
 0.88A 3b0wB-4cuoA:
undetectable		 3b0wB-4cuoA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exn INTERLEUKIN-34

(Mus musculus) 		PF15036
(IL34) 		3 LEU A 133
VAL A  85
ARG A  88
 None
 0.87A 3b0wB-4exnA:
undetectable		 3b0wB-4exnA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hly K9

(Human
gammaherpesvirus
8) 		PF00605
(IRF) 		3 LEU A  39
VAL A  54
ARG A  75
 None
 0.85A 3b0wB-4hlyA:
undetectable		 3b0wB-4hlyA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I

(Escherichia
coli) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		3 LEU A  91
VAL A  42
ARG A  35
 None
 0.79A 3b0wB-4js5A:
undetectable		 3b0wB-4js5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7c AMINOPEPTIDASE C

(Lactobacillus
rhamnosus) 		PF03051
(Peptidase_C1_2) 		3 LEU A 257
VAL A 285
ARG A 289
 None
 0.83A 3b0wB-4k7cA:
undetectable		 3b0wB-4k7cA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh4 OSMC-LIKE PROTEIN

(Burkholderia
cenocepacia) 		PF02566
(OsmC) 		3 LEU A  73
VAL A  80
ARG A  76
 None
 0.87A 3b0wB-4mh4A:
undetectable		 3b0wB-4mh4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7p MALTOKINASE

(Mycobacterium
tuberculosis) 		no annotation 3 LEU A  65
VAL A 162
ARG A 160
 None
 0.85A 3b0wB-4o7pA:
undetectable		 3b0wB-4o7pA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		3 LEU A 537
VAL A1002
ARG A1000
 None
 0.78A 3b0wB-4q8hA:
undetectable		 3b0wB-4q8hA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
DNA-DIRECTED RNA
POLYMERASE SUBUNIT H

(Thermococcus
kodakarensis) 		PF01191
(RNA_pol_Rpb5_C)
PF04998
(RNA_pol_Rpb1_5) 		3 LEU C 314
VAL H  80
ARG H  77
 None
 0.74A 3b0wB-4qiwC:
undetectable		 3b0wB-4qiwC:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		3 LEU A 315
VAL A  30
ARG A  33
 None
 0.91A 3b0wB-4qmkA:
undetectable		 3b0wB-4qmkA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LEU A 162
VAL A 137
ARG A 140
 None
 0.86A 3b0wB-4redA:
undetectable		 3b0wB-4redA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		3 LEU A  57
VAL A 261
ARG A 267
 None
PLP  A1458 (-4.1A)
None
 0.84A 3b0wB-4uhmA:
undetectable		 3b0wB-4uhmA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE

(Pectobacterium
atrosepticum) 		PF02275
(CBAH) 		3 LEU A 153
VAL A 281
ARG A   3
 None
 0.86A 3b0wB-4wl2A:
undetectable		 3b0wB-4wl2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aog CATIONIC PEROXIDASE
SPC4

(Sorghum bicolor) 		PF00141
(peroxidase) 		3 LEU A  93
VAL A 136
ARG A 330
 None
 0.90A 3b0wB-5aogA:
undetectable		 3b0wB-5aogA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LEU A 287
VAL A 361
ARG A 367
 None
 0.30A 3b0wB-5c4tA:
34.2		 3b0wB-5c4tA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18

(Mus musculus) 		PF00443
(UCH) 		3 LEU A 300
VAL A 338
ARG A 320
 None
 0.91A 3b0wB-5chvA:
undetectable		 3b0wB-5chvA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		3 LEU A  80
VAL A 255
ARG A 277
 None
 0.75A 3b0wB-5ejjA:
undetectable		 3b0wB-5ejjA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g23 TYPE-IV LIKE PILIN
TTHA1219

(Thermus
thermophilus) 		no annotation 3 LEU A  67
VAL A 173
ARG A 236
 None
 0.88A 3b0wB-5g23A:
undetectable		 3b0wB-5g23A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA

(Homo sapiens;
synthetic
construct) 		no annotation 3 LEU B1023
VAL B1087
ARG B1028
 None
 0.81A 3b0wB-5jcpB:
undetectable		 3b0wB-5jcpB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjt SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Arabidopsis
thaliana) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5)
PF13431
(TPR_17) 		3 LEU A 209
VAL A 320
ARG A 357
 None
 0.82A 3b0wB-5jjtA:
undetectable		 3b0wB-5jjtA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjx SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3

(Homo sapiens) 		no annotation 3 LEU A 337
VAL A 364
ARG A 370
 None
None
UNX  A 402 ( 4.0A)
 0.90A 3b0wB-5jjxA:
undetectable		 3b0wB-5jjxA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwy PHOSPHATIDYLGLYCEROP
HOSPHATASE B

(Escherichia
coli) 		PF01569
(PAP2) 		3 LEU A 237
VAL A 175
ARG A 181
 None
 0.87A 3b0wB-5jwyA:
3.7		 3b0wB-5jwyA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		3 LEU A 173
VAL A 221
ARG A 174
 None
 0.82A 3b0wB-5lfnA:
undetectable		 3b0wB-5lfnA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmx DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT
RPAC1,DNA-DIRECTED
RNA POLYMERASES I
AND III SUBUNIT
RPAC1

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		3 LEU C 192
VAL C  91
ARG C 100
 LEU  C 192 ( 0.6A)
VAL  C  91 ( 0.6A)
ARG  C 100 ( 0.6A)
 0.83A 3b0wB-5lmxC:
undetectable		 3b0wB-5lmxC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN

(Chaetomium
thermophilum) 		no annotation 3 LEU A1702
VAL A1768
ARG A1772
 None
 0.86A 3b0wB-5nnlA:
undetectable		 3b0wB-5nnlA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o98 ALCOHOL
DEHYDROGENASE 1

(Catharanthus
roseus) 		no annotation 3 LEU A 280
VAL A  92
ARG A 161
 None
 0.85A 3b0wB-5o98A:
undetectable		 3b0wB-5o98A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		3 LEU A 127
VAL A 442
ARG A 457
 None
 0.69A 3b0wB-5ohkA:
undetectable		 3b0wB-5ohkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN SMALL
SUBUNIT

(Clostridioides
difficile) 		no annotation 3 LEU B 142
VAL B 132
ARG A 107
 None
FAD  B 300 (-3.8A)
None
 0.89A 3b0wB-5ol2B:
undetectable		 3b0wB-5ol2B:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szu ACYL-COA HYDROLASE

(Neisseria
meningitidis) 		PF03061
(4HBT) 		3 LEU A   7
VAL A  41
ARG A  48
 None
 0.84A 3b0wB-5szuA:
undetectable		 3b0wB-5szuA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twt PEROXIDASE PVI9

(Panicum
virgatum) 		PF00141
(peroxidase) 		3 LEU A  54
VAL A  93
ARG A 284
 None
 0.88A 3b0wB-5twtA:
undetectable		 3b0wB-5twtA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4a GLYCOSYLTRANSFERASE
(DUF1792)

(Streptococcus
sanguinis) 		PF08759
(GT-D) 		3 LEU A 143
VAL A 187
ARG A 194
 None
 0.82A 3b0wB-5v4aA:
undetectable		 3b0wB-5v4aA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 3 LEU A 224
VAL A  67
ARG A 237
 None
 0.84A 3b0wB-5wt4A:
undetectable		 3b0wB-5wt4A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LEU A 180
VAL A 233
ARG A 258
 None
None
PEG  A 508 ( 4.1A)
 0.72A 3b0wB-5x8gA:
undetectable		 3b0wB-5x8gA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbc NSP1 PROTEIN

(Porcine
epidemic
diarrhea virus) 		no annotation 3 LEU A 110
VAL A  74
ARG A 107
 None
 0.85A 3b0wB-5xbcA:
undetectable		 3b0wB-5xbcA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon TRANSCRIPTION
ELONGATION FACTOR
SPT4

(Komagataella
phaffii) 		PF06093
(Spt4) 		3 LEU V  72
VAL V  18
ARG V 108
 None
 0.84A 3b0wB-5xonV:
undetectable		 3b0wB-5xonV:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c33 5'-3' EXONUCLEASE

(Mycolicibacterium
smegmatis) 		no annotation 3 LEU A 231
VAL A 266
ARG A 268
 None
 0.79A 3b0wB-6c33A:
undetectable		 3b0wB-6c33A:
14.98