SIMILAR PATTERNS OF AMINO ACIDS FOR 3B0W_A_DGXA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		5 GLN A  10
LEU A 315
CYH A  51
ALA A  48
ALA A 314
 None
None
ZN  A1001 (-2.3A)
None
None
 1.28A 3b0wA-1fn9A:
1.1		 3b0wA-1fn9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		5 LEU A 472
ALA A 433
ALA A 666
VAL A 667
HIS A 594
 None
None
None
None
FE  A 703 ( 3.4A)
 1.28A 3b0wA-1h76A:
0.0		 3b0wA-1h76A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 LEU A  41
CYH A  74
ALA A 138
ALA A  56
VAL A  58
 None
 1.03A 3b0wA-1k8gA:
0.0		 3b0wA-1k8gA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		7 GLN A 228
CYH A 262
ALA A 269
VAL A 318
PHE A 330
LEU A 338
HIS A 423
 ARL  A 800 (-4.7A)
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
None
ARL  A 800 (-3.6A)
ARL  A 800 ( 4.8A)
ARL  A 800 ( 4.3A)
 1.11A 3b0wA-1nq7A:
28.5		 3b0wA-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		9 GLN A 228
LEU A 234
CYH A 262
ALA A 269
MET A 307
ALA A 310
VAL A 318
PHE A 330
LEU A 338
 ARL  A 800 (-4.7A)
None
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
ARL  A 800 (-3.7A)
ARL  A 800 ( 4.1A)
None
ARL  A 800 (-3.6A)
ARL  A 800 ( 4.8A)
 0.87A 3b0wA-1nq7A:
28.5		 3b0wA-1nq7A:
49.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaz THIOREDOXIN 1

(Escherichia
coli) 		PF00085
(Thioredoxin) 		5 LEU A 113
LEU A  56
ALA A 107
MET A  51
ALA A  53
 None
 1.10A 3b0wA-1oazA:
undetectable		 3b0wA-1oazA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmn ALPHA-1-ANTICHYMOTRY
PSIN

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 306
LEU A 303
ALA A  34
PHE A  96
LEU A 103
 None
 1.23A 3b0wA-1qmnA:
0.0		 3b0wA-1qmnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		5 LEU A 485
LEU A 461
ALA A 502
PHE A 392
LEU A 379
 None
 1.23A 3b0wA-1un9A:
undetectable		 3b0wA-1un9A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vch PHOSPHORIBOSYLTRANSF
ERASE-RELATED
PROTEIN

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 LEU A 175
LEU A  17
VAL A  15
PHE A  37
LEU A  66
 None
 1.24A 3b0wA-1vchA:
undetectable		 3b0wA-1vchA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE

(Nostoc sp. PCC
7120) 		PF00266
(Aminotran_5) 		5 LEU A 188
ALA A 156
ALA A 203
VAL A 200
LEU A 139
 None
 1.29A 3b0wA-1vjoA:
undetectable		 3b0wA-1vjoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		5 MET A 423
ALA A 428
VAL A 351
PHE A 241
LEU A 378
 None
 1.27A 3b0wA-1ytmA:
0.0		 3b0wA-1ytmA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02306
(Phage_G) 		5 LEU 2  42
LEU 2  18
CYH 2  90
ALA 2  77
HIS 2 116
 None
 1.22A 3b0wA-2bpa2:
undetectable		 3b0wA-2bpa2:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 342
LEU A 345
ALA A 431
VAL A 432
LEU A 301
 OHT  A 500 ( 4.7A)
OHT  A 500 (-4.3A)
OHT  A 500 (-4.3A)
None
None
 1.27A 3b0wA-2gpvA:
18.5		 3b0wA-2gpvA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 LEU A 724
MET A 680
ALA A 681
VAL A 713
LEU A 795
 None
ACT  A 950 ( 4.5A)
None
None
None
 1.26A 3b0wA-2hg4A:
undetectable		 3b0wA-2hg4A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6v GENERAL SECRETION
PATHWAY PROTEIN C

(Vibrio cholerae) 		no annotation 5 LEU A 264
LEU A 269
ALA A 261
VAL A 241
PHE A 250
 None
 1.09A 3b0wA-2i6vA:
undetectable		 3b0wA-2i6vA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ism PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF07995
(GSDH) 		5 LEU A 351
LEU A  21
ALA A 274
ALA A 310
PHE A 268
 None
 1.28A 3b0wA-2ismA:
undetectable		 3b0wA-2ismA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsw TALIN-1

(Mus musculus) 		PF01608
(I_LWEQ) 		5 LEU A2470
LEU A2424
ALA A2353
ALA A2411
VAL A2415
 None
 1.06A 3b0wA-2jswA:
undetectable		 3b0wA-2jswA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 LEU A  91
LEU A 442
ALA A  98
ALA A 441
VAL A 437
 None
 1.04A 3b0wA-2nx9A:
undetectable		 3b0wA-2nx9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjd RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE C

(Escherichia
coli) 		PF05175
(MTS)
PF08468
(MTS_N) 		5 LEU A 188
LEU A 210
ALA A 303
VAL A 203
PHE A 255
 None
 1.22A 3b0wA-2pjdA:
undetectable		 3b0wA-2pjdA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		5 LEU A 270
LEU A 274
ALA A 183
ALA A 192
HIS A 198
 None
None
HEM  A 600 (-3.9A)
None
None
 1.30A 3b0wA-2r7aA:
undetectable		 3b0wA-2r7aA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 LEU A 894
LEU A 765
ALA A 705
MET A 899
ALA A 898
 None
 1.29A 3b0wA-2vcaA:
undetectable		 3b0wA-2vcaA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A  20
CYH A 401
ALA A 381
VAL A 387
PHE A 337
 None
 1.19A 3b0wA-3aatA:
undetectable		 3b0wA-3aatA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 520
ALA A 626
VAL A 624
PHE A 568
LEU A 470
 None
 1.17A 3b0wA-3b9pA:
undetectable		 3b0wA-3b9pA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A2189
LEU A2182
ALA A2091
ALA A2133
PHE A3021
 None
 1.23A 3b0wA-3cmvA:
undetectable		 3b0wA-3cmvA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		5 GLN A 406
ALA A 403
ALA A 316
PHE A 289
HIS A 279
 None
 1.23A 3b0wA-3dc8A:
undetectable		 3b0wA-3dc8A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5b ISOCITRATE LYASE

(Brucella
abortus) 		PF00463
(ICL) 		5 LEU A 203
ALA A 221
VAL A 220
PHE A 341
LEU A 332
 None
 1.28A 3b0wA-3e5bA:
undetectable		 3b0wA-3e5bA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9n PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Corynebacterium
glutamicum) 		PF00106
(adh_short) 		5 LEU A  42
ALA A  80
ALA A  31
VAL A  29
LEU A 119
 None
 1.23A 3b0wA-3e9nA:
undetectable		 3b0wA-3e9nA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 LEU A 409
LEU A 398
ALA A 381
ALA A 185
VAL A 183
 None
 1.22A 3b0wA-3ie1A:
undetectable		 3b0wA-3ie1A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 LEU A  97
LEU A 103
ALA A 108
VAL A 112
LEU A  55
 None
 1.26A 3b0wA-3im8A:
undetectable		 3b0wA-3im8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		5 LEU A  96
LEU A 102
ALA A 107
VAL A 111
LEU A  56
 None
 1.31A 3b0wA-3im9A:
undetectable		 3b0wA-3im9A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		5 LEU A 199
LEU A 223
MET A 253
VAL A 250
LEU A 264
 None
 1.24A 3b0wA-3ivrA:
undetectable		 3b0wA-3ivrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 LEU A 252
LEU A 435
ALA A 394
ALA A 407
VAL A 429
 None
 1.28A 3b0wA-3ju8A:
undetectable		 3b0wA-3ju8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		5 GLN A  31
MET A  24
ALA A  25
VAL A  14
HIS A 143
 None
 1.29A 3b0wA-3l6dA:
undetectable		 3b0wA-3l6dA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		5 LEU X  34
LEU X  30
ALA X  94
ALA X  48
LEU X 133
 None
 1.17A 3b0wA-3m7mX:
undetectable		 3b0wA-3m7mX:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3men ACETYLPOLYAMINE
AMINOHYDROLASE

(Burkholderia
pseudomallei) 		PF00850
(Hist_deacetyl) 		5 GLN A   9
CYH A 167
ALA A 149
VAL A 315
HIS A  62
 None
SO4  A 401 ( 4.2A)
None
None
None
 1.12A 3b0wA-3menA:
undetectable		 3b0wA-3menA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pas TETR FAMILY
TRANSCRIPTION
REGULATOR

(Marinobacter
hydrocarbonoclasticus) 		PF00440
(TetR_N)
PF16295
(TetR_C_10) 		5 GLN A  87
LEU A  84
LEU A  80
ALA A  70
ALA A 132
 None
None
None
None
PGO  A 216 ( 4.6A)
 1.11A 3b0wA-3pasA:
2.2		 3b0wA-3pasA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgv HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Klebsiella
pneumoniae) 		PF08282
(Hydrolase_3) 		5 LEU A 206
ALA A 211
ALA A 199
VAL A 198
LEU A  56
 None
 1.09A 3b0wA-3pgvA:
undetectable		 3b0wA-3pgvA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13416
(SBP_bac_8) 		5 LEU A 100
LEU A 106
MET A 271
ALA A 272
VAL A  89
 LEU  A 100 ( 0.6A)
LEU  A 106 ( 0.6A)
ALA  A 289 ( 3.7A)
ALA  A 272 ( 0.0A)
VAL  A  89 ( 0.6A)
 1.20A 3b0wA-3pu5A:
undetectable		 3b0wA-3pu5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7b NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF17290
(Arena_ncap_C) 		5 LEU A 370
LEU A 365
ALA A 376
CYH A 534
LEU A 531
 None
 1.16A 3b0wA-3q7bA:
undetectable		 3b0wA-3q7bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ros NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00171
(Aldedh) 		5 GLN A 317
LEU A 314
CYH A 263
ALA A 310
LEU A 205
 None
 1.27A 3b0wA-3rosA:
undetectable		 3b0wA-3rosA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Coxiella
burnetii) 		PF00698
(Acyl_transf_1) 		5 LEU A 100
LEU A 106
ALA A 111
VAL A 115
LEU A  57
 None
 1.27A 3b0wA-3tqeA:
undetectable		 3b0wA-3tqeA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woy CLIP-ASSOCIATING
PROTEIN 2

(Homo sapiens) 		PF12348
(CLASP_N) 		5 LEU A  99
LEU A 113
ALA A 156
VAL A 160
LEU A 216
 None
 1.16A 3b0wA-3woyA:
undetectable		 3b0wA-3woyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 493
ALA A 490
VAL A 393
LEU A 481
HIS A 132
 None
None
None
None
CU  A 616 (-3.2A)
 1.22A 3b0wA-3x1bA:
undetectable		 3b0wA-3x1bA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		5 ALA A 117
ALA A  40
VAL A  42
PHE A  19
HIS A  94
 None
None
None
None
MN  A1132 (-3.6A)
 1.24A 3b0wA-4bifA:
undetectable		 3b0wA-4bifA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 375
ALA A 110
ALA A 327
CYH A 306
LEU A 286
 None
 1.04A 3b0wA-4dhgA:
undetectable		 3b0wA-4dhgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e44 CENTROMERE PROTEIN S
CENTROMERE PROTEIN X

(Homo sapiens) 		PF09415
(CENP-X)
PF15630
(CENP-S) 		5 LEU B  74
CYH A  58
ALA B  49
VAL B  46
PHE B  10
 None
 1.28A 3b0wA-4e44B:
undetectable		 3b0wA-4e44B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 LEU A 239
LEU A 241
ALA A 223
LEU A  82
HIS A 200
 None
 1.30A 3b0wA-4eclA:
undetectable		 3b0wA-4eclA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ess OR187

(synthetic
construct) 		PF01661
(Macro) 		5 LEU A 103
LEU A 105
CYH A  49
ALA A  60
ALA A  18
 None
 1.25A 3b0wA-4essA:
undetectable		 3b0wA-4essA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1)
PF16415
(CNOT1_CAF1_bind) 		5 LEU A1266
LEU A1286
ALA A1261
CYH B 148
LEU B 147
 None
 1.16A 3b0wA-4gmjA:
undetectable		 3b0wA-4gmjA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 LEU A 146
ALA A 398
ALA A 142
VAL A 139
LEU A 169
 None
 1.25A 3b0wA-4gniA:
undetectable		 3b0wA-4gniA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h79 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Thermobifida
fusca) 		PF09485
(CRISPR_Cse2) 		5 GLN A 171
LEU A 168
LEU A 163
ALA A 187
VAL A 116
 None
 1.21A 3b0wA-4h79A:
2.8		 3b0wA-4h79A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 GLN A   6
LEU A 104
ALA A  17
MET A 352
ALA A 355
 None
 1.31A 3b0wA-4inaA:
undetectable		 3b0wA-4inaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		5 LEU A 234
LEU A   5
ALA A  27
VAL A  34
LEU A  43
 None
 1.17A 3b0wA-4ituA:
undetectable		 3b0wA-4ituA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjn HISTONE H2A.2
HISTONE H2B.2

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		5 LEU C  94
LEU C  98
ALA C  67
VAL D  69
PHE C  26
 None
 1.29A 3b0wA-4jjnC:
undetectable		 3b0wA-4jjnC:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		5 LEU A 238
ALA A 213
ALA A 279
LEU A 332
HIS A 204
 None
 1.05A 3b0wA-4jndA:
undetectable		 3b0wA-4jndA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2j AMINOTRANSFERASE

(Streptomyces
lavendulae) 		PF00155
(Aminotran_1_2) 		5 ALA A 246
ALA A 239
VAL A 218
CYH A 128
HIS A 104
 None
 0.98A 3b0wA-4m2jA:
undetectable		 3b0wA-4m2jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 CYH A  50
ALA A 303
ALA A 275
VAL A 269
LEU A  53
 None
 1.28A 3b0wA-4mggA:
undetectable		 3b0wA-4mggA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 776
LEU A 779
PHE A 859
CYH A 861
LEU A 869
 None
 1.21A 3b0wA-4n1aA:
undetectable		 3b0wA-4n1aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 776
LEU A 779
PHE A 859
CYH A 861
LEU A 869
 None
 1.20A 3b0wA-4nh0A:
undetectable		 3b0wA-4nh0A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		5 ALA A  44
MET A 261
ALA A 262
VAL A 142
LEU A  85
 None
 1.18A 3b0wA-4pafA:
undetectable		 3b0wA-4pafA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 LEU A  66
ALA A 151
ALA A  50
VAL A  49
LEU A 174
 None
None
None
HO4  A 401 (-4.5A)
None
 1.25A 3b0wA-4pvvA:
undetectable		 3b0wA-4pvvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A2862
MET A2830
ALA A2829
VAL A2971
CYH A2944
 None
 1.23A 3b0wA-4qyrA:
undetectable		 3b0wA-4qyrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2825
ALA A2862
MET A2830
ALA A2829
VAL A2971
 None
 1.20A 3b0wA-4qyrA:
undetectable		 3b0wA-4qyrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roq MALYL-COA
LYASE/BETA-METHYLMAL
YL-COA LYASE

(Methylobacterium
extorquens) 		PF03328
(HpcH_HpaI) 		5 LEU A  41
MET A 101
VAL A  38
CYH A 217
LEU A 222
 None
 1.28A 3b0wA-4roqA:
undetectable		 3b0wA-4roqA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLN A 289
CYH A 323
ALA A 330
PHE A 391
HIS A 484
 4D8  A 601 ( 2.7A)
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.5A)
None
 0.89A 3b0wA-4s15A:
30.1		 3b0wA-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 GLN A 289
LEU A 295
CYH A 323
ALA A 330
MET A 368
ALA A 371
VAL A 379
PHE A 391
CYH A 396
 4D8  A 601 ( 2.7A)
None
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 (-4.0A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
4D8  A 601 ( 4.7A)
 0.60A 3b0wA-4s15A:
30.1		 3b0wA-4s15A:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 LEU A 757
LEU A 761
ALA A  45
VAL A  46
LEU A 131
 None
 0.94A 3b0wA-4u1rA:
undetectable		 3b0wA-4u1rA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1
HYDRATASE CHSH2

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N)
no annotation 		5 LEU B  78
LEU B  80
ALA A  67
VAL B  50
PHE B  19
 None
 1.17A 3b0wA-4w78B:
undetectable		 3b0wA-4w78B:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgh CITRATE SYNTHASE

(Burkholderia
thailandensis) 		PF00285
(Citrate_synt) 		5 LEU A 334
LEU A 336
ALA A 223
PHE A 385
HIS A 231
 None
None
None
None
EDO  A 509 ( 3.2A)
 1.19A 3b0wA-4xghA:
undetectable		 3b0wA-4xghA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkm XYLOSE ISOMERASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 211
ALA A 218
ALA A 156
VAL A 146
LEU A 121
 None
 1.30A 3b0wA-4xkmA:
undetectable		 3b0wA-4xkmA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 LEU A 299
LEU A 296
ALA A 244
CYH A 405
LEU A 383
 None
 1.29A 3b0wA-4xwhA:
undetectable		 3b0wA-4xwhA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zba PCURE2P8

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A  12
LEU A  10
ALA A  17
ALA A  23
HIS A 200
 CL  A 301 (-4.4A)
None
None
None
None
 1.04A 3b0wA-4zbaA:
undetectable		 3b0wA-4zbaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmu DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF)
PF01590
(GAF) 		5 LEU A 246
LEU A 256
ALA A 305
ALA A 266
VAL A 268
 None
 1.20A 3b0wA-4zmuA:
undetectable		 3b0wA-4zmuA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a) 		5 LEU C 809
LEU C 811
ALA C 780
VAL C 856
LEU C 948
 None
 1.19A 3b0wA-5a6fC:
undetectable		 3b0wA-5a6fC:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 LEU A 242
ALA A 310
ALA A 345
VAL A 343
PHE A 290
 None
 1.27A 3b0wA-5c1bA:
undetectable		 3b0wA-5c1bA:
15.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 GLN A 286
LEU A 287
LEU A 292
CYH A 320
ALA A 327
ALA A 368
VAL A 376
PHE A 388
CYH A 393
LEU A 396
HIS A 479
 None
None
None
GOL  A 607 ( 4.0A)
None
None
None
GOL  A 607 ( 4.5A)
None
None
None
 0.68A 3b0wA-5c4tA:
33.4		 3b0wA-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 GLN A 286
LEU A 287
LEU A 292
CYH A 320
ALA A 327
MET A 365
ALA A 368
VAL A 376
PHE A 388
CYH A 393
LEU A 396
 None
None
None
GOL  A 607 ( 4.0A)
None
None
None
None
GOL  A 607 ( 4.5A)
None
None
 0.68A 3b0wA-5c4tA:
33.4		 3b0wA-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 292
PHE A 388
CYH A 393
LEU A 396
HIS A 479
 None
GOL  A 607 ( 4.5A)
None
None
None
 1.11A 3b0wA-5c4tA:
33.4		 3b0wA-5c4tA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es2 UNCHARACTERIZED
PROTEIN LPG0634

(Legionella
pneumophila) 		PF16848
(SoDot-IcmSS) 		5 LEU A 133
LEU A 129
ALA A  78
VAL A  82
LEU A  38
 None
 1.27A 3b0wA-5es2A:
undetectable		 3b0wA-5es2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLN C 287
LEU C 336
CYH C 696
ALA C 360
LEU C 401
 None
ACT  C1740 ( 4.5A)
None
None
None
 1.11A 3b0wA-5g5gC:
undetectable		 3b0wA-5g5gC:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		5 LEU A 241
MET A 182
ALA A 183
VAL A 328
LEU A 449
 None
 1.10A 3b0wA-5g5zA:
undetectable		 3b0wA-5g5zA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 6 LEU A 945
LEU A 998
ALA A 958
MET A 940
ALA A 941
VAL A 991
 None
 1.46A 3b0wA-5hdtA:
undetectable		 3b0wA-5hdtA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 LEU B 621
LEU B 603
VAL B 629
PHE B 657
LEU B 675
 None
 1.30A 3b0wA-5hz1B:
undetectable		 3b0wA-5hz1B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 LEU B1088
LEU B1022
ALA B1148
VAL B1306
LEU B1132
 None
 1.22A 3b0wA-5jtwB:
undetectable		 3b0wA-5jtwB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 CYH B 109
ALA B 104
ALA B  48
VAL B  78
LEU B 113
 None
 1.16A 3b0wA-5k1cB:
undetectable		 3b0wA-5k1cB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 588
LEU A 549
MET A 578
VAL A 256
LEU A 158
 None
 1.24A 3b0wA-5lp4A:
undetectable		 3b0wA-5lp4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 5 CYH C 112
ALA C  34
MET C  43
ALA C  41
VAL C   9
 None
 1.26A 3b0wA-5mg5C:
undetectable		 3b0wA-5mg5C:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 GLN B 184
LEU B 199
ALA B 189
CYH A 380
LEU A 377
 None
 1.26A 3b0wA-5nd1B:
undetectable		 3b0wA-5nd1B:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 GLN B 184
LEU B 199
PHE A 431
CYH A 380
LEU A 377
 None
 1.27A 3b0wA-5nd1B:
undetectable		 3b0wA-5nd1B:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 LEU A 255
LEU A 437
ALA A 396
ALA A 409
VAL A 431
 None
 1.29A 3b0wA-5u0lA:
undetectable		 3b0wA-5u0lA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		5 LEU A 148
LEU A 150
ALA A 106
VAL A  76
PHE A 311
 None
 1.04A 3b0wA-5vslA:
undetectable		 3b0wA-5vslA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 5 LEU A 435
LEU A 439
ALA A 410
ALA A 477
VAL A 468
 None
 1.21A 3b0wA-5w1eA:
undetectable		 3b0wA-5w1eA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhi PROTEIN YIIM

(Escherichia
coli) 		no annotation 5 LEU A 191
LEU A 197
ALA A 175
VAL A 113
HIS A  64
 None
 1.29A 3b0wA-5yhiA:
undetectable		 3b0wA-5yhiA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar2 SARCOLEMMAL
MEMBRANE-ASSOCIATED
PROTEIN

(Homo sapiens) 		no annotation 5 ALA A   6
PHE A  17
CYH A  48
LEU A  51
HIS A  55
 None
 1.30A 3b0wA-6ar2A:
undetectable		 3b0wA-6ar2A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4c -

(-) 		no annotation 5 LEU A  93
LEU A  95
ALA A  53
VAL A  23
PHE A 254
 None
 0.98A 3b0wA-6b4cA:
undetectable		 3b0wA-6b4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5c KATANIN P60
ATPASE-CONTAINING
SUBUNIT A-LIKE 1

(Homo sapiens) 		no annotation 5 LEU A 245
ALA A 356
VAL A 354
PHE A 293
LEU A 194
 None
 1.18A 3b0wA-6b5cA:
undetectable		 3b0wA-6b5cA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 LEU H 258
ALA H 326
ALA H 361
VAL H 359
PHE H 306
 None
 1.25A 3b0wA-6chsH:
undetectable		 3b0wA-6chsH:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 5 ALA G 408
ALA G 401
VAL G 433
CYH G 479
LEU G 459
 None
 1.24A 3b0wA-6criG:
undetectable		 3b0wA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 LEU A  73
ALA A 215
ALA A  71
PHE A  22
LEU A  17
 None
 1.14A 3b0wA-6et9A:
undetectable		 3b0wA-6et9A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 621
MET A 650
ALA A 649
VAL A 646
LEU A 676
 None
 1.25A 3b0wA-6f8zA:
undetectable		 3b0wA-6f8zA:
15.00