SIMILAR PATTERNS OF AMINO ACIDS FOR 3B0W_A_DGXA1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		5 GLN A  10
LEU A 315
CYH A  51
ALA A  48
ALA A 314
 None
None
ZN  A1001 (-2.3A)
None
None
 1.28A 3b0wA-1fn9A:
1.1		 3b0wA-1fn9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		5 LEU A 472
ALA A 433
ALA A 666
VAL A 667
HIS A 594
 None
None
None
None
FE  A 703 ( 3.4A)
 1.28A 3b0wA-1h76A:
0.0		 3b0wA-1h76A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8g TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		5 LEU A  41
CYH A  74
ALA A 138
ALA A  56
VAL A  58
 None
 1.03A 3b0wA-1k8gA:
0.0		 3b0wA-1k8gA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		7 GLN A 228
CYH A 262
ALA A 269
VAL A 318
PHE A 330
LEU A 338
HIS A 423
 ARL  A 800 (-4.7A)
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
None
ARL  A 800 (-3.6A)
ARL  A 800 ( 4.8A)
ARL  A 800 ( 4.3A)
 1.11A 3b0wA-1nq7A:
28.5		 3b0wA-1nq7A:
49.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		9 GLN A 228
LEU A 234
CYH A 262
ALA A 269
MET A 307
ALA A 310
VAL A 318
PHE A 330
LEU A 338
 ARL  A 800 (-4.7A)
None
ARL  A 800 (-3.5A)
ARL  A 800 ( 3.9A)
ARL  A 800 (-3.7A)
ARL  A 800 ( 4.1A)
None
ARL  A 800 (-3.6A)
ARL  A 800 ( 4.8A)
 0.87A 3b0wA-1nq7A:
28.5		 3b0wA-1nq7A:
49.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaz THIOREDOXIN 1

(Escherichia
coli) 		PF00085
(Thioredoxin) 		5 LEU A 113
LEU A  56
ALA A 107
MET A  51
ALA A  53
 None
 1.10A 3b0wA-1oazA:
undetectable		 3b0wA-1oazA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmn ALPHA-1-ANTICHYMOTRY
PSIN

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 306
LEU A 303
ALA A  34
PHE A  96
LEU A 103
 None
 1.23A 3b0wA-1qmnA:
0.0		 3b0wA-1qmnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		5 LEU A 485
LEU A 461
ALA A 502
PHE A 392
LEU A 379
 None
 1.23A 3b0wA-1un9A:
undetectable		 3b0wA-1un9A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vch PHOSPHORIBOSYLTRANSF
ERASE-RELATED
PROTEIN

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 LEU A 175
LEU A  17
VAL A  15
PHE A  37
LEU A  66
 None
 1.24A 3b0wA-1vchA:
undetectable		 3b0wA-1vchA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE

(Nostoc sp. PCC
7120) 		PF00266
(Aminotran_5) 		5 LEU A 188
ALA A 156
ALA A 203
VAL A 200
LEU A 139
 None
 1.29A 3b0wA-1vjoA:
undetectable		 3b0wA-1vjoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytm PHOSPHOENOLPYRUVATE
CARBOXYKINASE [ATP]

(Anaerobiospirillum
succiniciproducens) 		PF01293
(PEPCK_ATP) 		5 MET A 423
ALA A 428
VAL A 351
PHE A 241
LEU A 378
 None
 1.27A 3b0wA-1ytmA:
0.0		 3b0wA-1ytmA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02306
(Phage_G) 		5 LEU 2  42
LEU 2  18
CYH 2  90
ALA 2  77
HIS 2 116
 None
 1.22A 3b0wA-2bpa2:
undetectable		 3b0wA-2bpa2:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 342
LEU A 345
ALA A 431
VAL A 432
LEU A 301
 OHT  A 500 ( 4.7A)
OHT  A 500 (-4.3A)
OHT  A 500 (-4.3A)
None
None
 1.27A 3b0wA-2gpvA:
18.5		 3b0wA-2gpvA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 LEU A 724
MET A 680
ALA A 681
VAL A 713
LEU A 795
 None
ACT  A 950 ( 4.5A)
None
None
None
 1.26A 3b0wA-2hg4A:
undetectable		 3b0wA-2hg4A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6v GENERAL SECRETION
PATHWAY PROTEIN C

(Vibrio cholerae) 		no annotation 5 LEU A 264
LEU A 269
ALA A 261
VAL A 241
PHE A 250
 None
 1.09A 3b0wA-2i6vA:
undetectable		 3b0wA-2i6vA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ism PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF07995
(GSDH) 		5 LEU A 351
LEU A  21
ALA A 274
ALA A 310
PHE A 268
 None
 1.28A 3b0wA-2ismA:
undetectable		 3b0wA-2ismA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsw TALIN-1

(Mus musculus) 		PF01608
(I_LWEQ) 		5 LEU A2470
LEU A2424
ALA A2353
ALA A2411
VAL A2415
 None
 1.06A 3b0wA-2jswA:
undetectable		 3b0wA-2jswA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx9 OXALOACETATE
DECARBOXYLASE 2,
SUBUNIT ALPHA

(Vibrio cholerae) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 LEU A  91
LEU A 442
ALA A  98
ALA A 441
VAL A 437
 None
 1.04A 3b0wA-2nx9A:
undetectable		 3b0wA-2nx9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjd RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE C

(Escherichia
coli) 		PF05175
(MTS)
PF08468
(MTS_N) 		5 LEU A 188
LEU A 210
ALA A 303
VAL A 203
PHE A 255
 None
 1.22A 3b0wA-2pjdA:
undetectable		 3b0wA-2pjdA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7a BACTERIAL HEME
BINDING PROTEIN

(Shigella
dysenteriae) 		PF01497
(Peripla_BP_2) 		5 LEU A 270
LEU A 274
ALA A 183
ALA A 192
HIS A 198
 None
None
HEM  A 600 (-3.9A)
None
None
 1.30A 3b0wA-2r7aA:
undetectable		 3b0wA-2r7aA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 LEU A 894
LEU A 765
ALA A 705
MET A 899
ALA A 898
 None
 1.29A 3b0wA-2vcaA:
undetectable		 3b0wA-2vcaA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A  20
CYH A 401
ALA A 381
VAL A 387
PHE A 337
 None
 1.19A 3b0wA-3aatA:
undetectable		 3b0wA-3aatA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9p CG5977-PA, ISOFORM A

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 520
ALA A 626
VAL A 624
PHE A 568
LEU A 470
 None
 1.17A 3b0wA-3b9pA:
undetectable		 3b0wA-3b9pA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 LEU A2189
LEU A2182
ALA A2091
ALA A2133
PHE A3021
 None
 1.23A 3b0wA-3cmvA:
undetectable		 3b0wA-3cmvA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		5 GLN A 406
ALA A 403
ALA A 316
PHE A 289
HIS A 279
 None
 1.23A 3b0wA-3dc8A:
undetectable		 3b0wA-3dc8A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5b ISOCITRATE LYASE

(Brucella
abortus) 		PF00463
(ICL) 		5 LEU A 203
ALA A 221
VAL A 220
PHE A 341
LEU A 332
 None
 1.28A 3b0wA-3e5bA:
undetectable		 3b0wA-3e5bA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9n PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Corynebacterium
glutamicum) 		PF00106
(adh_short) 		5 LEU A  42
ALA A  80
ALA A  31
VAL A  29
LEU A 119
 None
 1.23A 3b0wA-3e9nA:
undetectable		 3b0wA-3e9nA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 LEU A 409
LEU A 398
ALA A 381
ALA A 185
VAL A 183
 None
 1.22A 3b0wA-3ie1A:
undetectable		 3b0wA-3ie1A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 LEU A  97
LEU A 103
ALA A 108
VAL A 112
LEU A  55
 None
 1.26A 3b0wA-3im8A:
undetectable		 3b0wA-3im8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im9 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Staphylococcus
aureus) 		PF00698
(Acyl_transf_1) 		5 LEU A  96
LEU A 102
ALA A 107
VAL A 111
LEU A  56
 None
 1.31A 3b0wA-3im9A:
undetectable		 3b0wA-3im9A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		5 LEU A 199
LEU A 223
MET A 253
VAL A 250
LEU A 264
 None
 1.24A 3b0wA-3ivrA:
undetectable		 3b0wA-3ivrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 LEU A 252
LEU A 435
ALA A 394
ALA A 407
VAL A 429
 None
 1.28A 3b0wA-3ju8A:
undetectable		 3b0wA-3ju8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		5 GLN A  31
MET A  24
ALA A  25
VAL A  14
HIS A 143
 None
 1.29A 3b0wA-3l6dA:
undetectable		 3b0wA-3l6dA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		5 LEU X  34
LEU X  30
ALA X  94
ALA X  48
LEU X 133
 None
 1.17A 3b0wA-3m7mX:
undetectable		 3b0wA-3m7mX:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3men ACETYLPOLYAMINE
AMINOHYDROLASE

(Burkholderia
pseudomallei) 		PF00850
(Hist_deacetyl) 		5 GLN A   9
CYH A 167
ALA A 149
VAL A 315
HIS A  62
 None
SO4  A 401 ( 4.2A)
None
None
None
 1.12A 3b0wA-3menA:
undetectable		 3b0wA-3menA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pas TETR FAMILY
TRANSCRIPTION
REGULATOR

(Marinobacter
hydrocarbonoclasticus) 		PF00440
(TetR_N)
PF16295
(TetR_C_10) 		5 GLN A  87
LEU A  84
LEU A  80
ALA A  70
ALA A 132
 None
None
None
None
PGO  A 216 ( 4.6A)
 1.11A 3b0wA-3pasA:
2.2		 3b0wA-3pasA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgv HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Klebsiella
pneumoniae) 		PF08282
(Hydrolase_3) 		5 LEU A 206
ALA A 211
ALA A 199
VAL A 198
LEU A  56
 None
 1.09A 3b0wA-3pgvA:
undetectable		 3b0wA-3pgvA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13416
(SBP_bac_8) 		5 LEU A 100
LEU A 106
MET A 271
ALA A 272
VAL A  89
 LEU  A 100 ( 0.6A)
LEU  A 106 ( 0.6A)
ALA  A 289 ( 3.7A)
ALA  A 272 ( 0.0A)
VAL  A  89 ( 0.6A)
 1.20A 3b0wA-3pu5A:
undetectable		 3b0wA-3pu5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7b NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF17290
(Arena_ncap_C) 		5 LEU A 370
LEU A 365
ALA A 376
CYH A 534
LEU A 531
 None
 1.16A 3b0wA-3q7bA:
undetectable		 3b0wA-3q7bA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ros NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00171
(Aldedh) 		5 GLN A 317
LEU A 314
CYH A 263
ALA A 310
LEU A 205
 None
 1.27A 3b0wA-3rosA:
undetectable		 3b0wA-3rosA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Coxiella
burnetii) 		PF00698
(Acyl_transf_1) 		5 LEU A 100
LEU A 106
ALA A 111
VAL A 115
LEU A  57
 None
 1.27A 3b0wA-3tqeA:
undetectable		 3b0wA-3tqeA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3woy CLIP-ASSOCIATING
PROTEIN 2

(Homo sapiens) 		PF12348
(CLASP_N) 		5 LEU A  99
LEU A 113
ALA A 156
VAL A 160
LEU A 216
 None
 1.16A 3b0wA-3woyA:
undetectable		 3b0wA-3woyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1b LACCASE

(Lentinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 493
ALA A 490
VAL A 393
LEU A 481
HIS A 132
 None
None
None
None
CU  A 616 (-3.2A)
 1.22A 3b0wA-3x1bA:
undetectable		 3b0wA-3x1bA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		5 ALA A 117
ALA A  40
VAL A  42
PHE A  19
HIS A  94
 None
None
None
None
MN  A1132 (-3.6A)
 1.24A 3b0wA-4bifA:
undetectable		 3b0wA-4bifA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhg MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Thermobispora
bispora) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 375
ALA A 110
ALA A 327
CYH A 306
LEU A 286
 None
 1.04A 3b0wA-4dhgA:
undetectable		 3b0wA-4dhgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e44 CENTROMERE PROTEIN S
CENTROMERE PROTEIN X

(Homo sapiens) 		PF09415
(CENP-X)
PF15630
(CENP-S) 		5 LEU B  74
CYH A  58
ALA B  49
VAL B  46
PHE B  10
 None
 1.28A 3b0wA-4e44B:
undetectable		 3b0wA-4e44B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecl SERINE RACEMASE

(Enterococcus
faecalis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 LEU A 239
LEU A 241
ALA A 223
LEU A  82
HIS A 200
 None
 1.30A 3b0wA-4eclA:
undetectable		 3b0wA-4eclA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ess OR187

(synthetic
construct) 		PF01661
(Macro) 		5 LEU A 103
LEU A 105
CYH A  49
ALA A  60
ALA A  18
 None
 1.25A 3b0wA-4essA:
undetectable		 3b0wA-4essA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1)
PF16415
(CNOT1_CAF1_bind) 		5 LEU A1266
LEU A1286
ALA A1261
CYH B 148
LEU B 147
 None
 1.16A 3b0wA-4gmjA:
undetectable		 3b0wA-4gmjA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 LEU A 146
ALA A 398
ALA A 142
VAL A 139
LEU A 169
 None
 1.25A 3b0wA-4gniA:
undetectable		 3b0wA-4gniA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h79 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Thermobifida
fusca) 		PF09485
(CRISPR_Cse2) 		5 GLN A 171
LEU A 168
LEU A 163
ALA A 187
VAL A 116
 None
 1.21A 3b0wA-4h79A:
2.8		 3b0wA-4h79A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ina SACCHAROPINE
DEHYDROGENASE

(Wolinella
succinogenes) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 GLN A   6
LEU A 104
ALA A  17
MET A 352
ALA A 355
 None
 1.31A 3b0wA-4inaA:
undetectable		 3b0wA-4inaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		5 LEU A 234
LEU A   5
ALA A  27
VAL A  34
LEU A  43
 None
 1.17A 3b0wA-4ituA:
undetectable		 3b0wA-4ituA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjn HISTONE H2A.2
HISTONE H2B.2

(Saccharomyces
cerevisiae) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		5 LEU C  94
LEU C  98
ALA C  67
VAL D  69
PHE C  26
 None
 1.29A 3b0wA-4jjnC:
undetectable		 3b0wA-4jjnC:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnd CA(2+)/CALMODULIN-DE
PENDENT PROTEIN
KINASE PHOSPHATASE

(Caenorhabditis
elegans) 		PF00481
(PP2C) 		5 LEU A 238
ALA A 213
ALA A 279
LEU A 332
HIS A 204
 None
 1.05A 3b0wA-4jndA:
undetectable		 3b0wA-4jndA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2j AMINOTRANSFERASE

(Streptomyces
lavendulae) 		PF00155
(Aminotran_1_2) 		5 ALA A 246
ALA A 239
VAL A 218
CYH A 128
HIS A 104
 None
 0.98A 3b0wA-4m2jA:
undetectable		 3b0wA-4m2jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 CYH A  50
ALA A 303
ALA A 275
VAL A 269
LEU A  53
 None
 1.28A 3b0wA-4mggA:
undetectable		 3b0wA-4mggA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 776
LEU A 779
PHE A 859
CYH A 861
LEU A 869
 None
 1.21A 3b0wA-4n1aA:
undetectable		 3b0wA-4n1aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 LEU A 776
LEU A 779
PHE A 859
CYH A 861
LEU A 869
 None
 1.20A 3b0wA-4nh0A:
undetectable		 3b0wA-4nh0A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		5 ALA A  44
MET A 261
ALA A 262
VAL A 142
LEU A  85
 None
 1.18A 3b0wA-4pafA:
undetectable		 3b0wA-4pafA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvv ADENOSINE KINASE

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		5 LEU A  66
ALA A 151
ALA A  50
VAL A  49
LEU A 174
 None
None
None
HO4  A 401 (-4.5A)
None
 1.25A 3b0wA-4pvvA:
undetectable		 3b0wA-4pvvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A2862
MET A2830
ALA A2829
VAL A2971
CYH A2944
 None
 1.23A 3b0wA-4qyrA:
undetectable		 3b0wA-4qyrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A2825
ALA A2862
MET A2830
ALA A2829
VAL A2971
 None
 1.20A 3b0wA-4qyrA:
undetectable		 3b0wA-4qyrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roq MALYL-COA
LYASE/BETA-METHYLMAL
YL-COA LYASE

(Methylobacterium
extorquens) 		PF03328
(HpcH_HpaI) 		5 LEU A  41
MET A 101
VAL A  38
CYH A 217
LEU A 222
 None
 1.28A 3b0wA-4roqA:
undetectable		 3b0wA-4roqA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLN A 289
CYH A 323
ALA A 330
PHE A 391
HIS A 484
 4D8  A 601 ( 2.7A)
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 ( 4.5A)
None
 0.89A 3b0wA-4s15A:
30.1		 3b0wA-4s15A:
53.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4s15 NUCLEAR RECEPTOR
ROR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 GLN A 289
LEU A 295
CYH A 323
ALA A 330
MET A 368
ALA A 371
VAL A 379
PHE A 391
CYH A 396
 4D8  A 601 ( 2.7A)
None
4D8  A 601 ( 4.0A)
4D8  A 601 (-3.1A)
4D8  A 601 (-4.0A)
4D8  A 601 ( 4.0A)
None
4D8  A 601 ( 4.5A)
4D8  A 601 ( 4.7A)
 0.60A 3b0wA-4s15A:
30.1		 3b0wA-4s15A:
53.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		5 LEU A 757
LEU A 761
ALA A  45
VAL A  46
LEU A 131
 None
 0.94A 3b0wA-4u1rA:
undetectable		 3b0wA-4u1rA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1
HYDRATASE CHSH2

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N)
no annotation 		5 LEU B  78
LEU B  80
ALA A  67
VAL B  50
PHE B  19
 None
 1.17A 3b0wA-4w78B:
undetectable		 3b0wA-4w78B:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgh CITRATE SYNTHASE

(Burkholderia
thailandensis) 		PF00285
(Citrate_synt) 		5 LEU A 334
LEU A 336
ALA A 223
PHE A 385
HIS A 231
 None
None
None
None
EDO  A 509 ( 3.2A)
 1.19A 3b0wA-4xghA:
undetectable		 3b0wA-4xghA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkm XYLOSE ISOMERASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 211
ALA A 218
ALA A 156
VAL A 146
LEU A 121
 None
 1.30A 3b0wA-4xkmA:
undetectable		 3b0wA-4xkmA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 LEU A 299
LEU A 296
ALA A 244
CYH A 405
LEU A 383
 None
 1.29A 3b0wA-4xwhA:
undetectable		 3b0wA-4xwhA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zba PCURE2P8

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A  12
LEU A  10
ALA A  17
ALA A  23
HIS A 200
 CL  A 301 (-4.4A)
None
None
None
None
 1.04A 3b0wA-4zbaA:
undetectable		 3b0wA-4zbaA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmu DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF)
PF01590
(GAF) 		5 LEU A 246
LEU A 256
ALA A 305
ALA A 266
VAL A 268
 None
 1.20A 3b0wA-4zmuA:
undetectable		 3b0wA-4zmuA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a) 		5 LEU C 809
LEU C 811
ALA C 780
VAL C 856
LEU C 948
 None
 1.19A 3b0wA-5a6fC:
undetectable		 3b0wA-5a6fC:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 LEU A 242
ALA A 310
ALA A 345
VAL A 343
PHE A 290
 None
 1.27A 3b0wA-5c1bA:
undetectable		 3b0wA-5c1bA:
15.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 GLN A 286
LEU A 287
LEU A 292
CYH A 320
ALA A 327
ALA A 368
VAL A 376
PHE A 388
CYH A 393
LEU A 396
HIS A 479
 None
None
None
GOL  A 607 ( 4.0A)
None
None
None
GOL  A 607 ( 4.5A)
None
None
None
 0.68A 3b0wA-5c4tA:
33.4		 3b0wA-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 GLN A 286
LEU A 287
LEU A 292
CYH A 320
ALA A 327
MET A 365
ALA A 368
VAL A 376
PHE A 388
CYH A 393
LEU A 396
 None
None
None
GOL  A 607 ( 4.0A)
None
None
None
None
GOL  A 607 ( 4.5A)
None
None
 0.68A 3b0wA-5c4tA:
33.4		 3b0wA-5c4tA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 292
PHE A 388
CYH A 393
LEU A 396
HIS A 479
 None
GOL  A 607 ( 4.5A)
None
None
None
 1.11A 3b0wA-5c4tA:
33.4		 3b0wA-5c4tA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es2 UNCHARACTERIZED
PROTEIN LPG0634

(Legionella
pneumophila) 		PF16848
(SoDot-IcmSS) 		5 LEU A 133
LEU A 129
ALA A  78
VAL A  82
LEU A  38
 None
 1.27A 3b0wA-5es2A:
undetectable		 3b0wA-5es2A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLN C 287
LEU C 336
CYH C 696
ALA C 360
LEU C 401
 None
ACT  C1740 ( 4.5A)
None
None
None
 1.11A 3b0wA-5g5gC:
undetectable		 3b0wA-5g5gC:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5z ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01547
(SBP_bac_1) 		5 LEU A 241
MET A 182
ALA A 183
VAL A 328
LEU A 449
 None
 1.10A 3b0wA-5g5zA:
undetectable		 3b0wA-5g5zA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 6 LEU A 945
LEU A 998
ALA A 958
MET A 940
ALA A 941
VAL A 991
 None
 1.46A 3b0wA-5hdtA:
undetectable		 3b0wA-5hdtA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 LEU B 621
LEU B 603
VAL B 629
PHE B 657
LEU B 675
 None
 1.30A 3b0wA-5hz1B:
undetectable		 3b0wA-5hz1B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 LEU B1088
LEU B1022
ALA B1148
VAL B1306
LEU B1132
 None
 1.22A 3b0wA-5jtwB:
undetectable		 3b0wA-5jtwB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 CYH B 109
ALA B 104
ALA B  48
VAL B  78
LEU B 113
 None
 1.16A 3b0wA-5k1cB:
undetectable		 3b0wA-5k1cB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)

(Helicobacter
pylori) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 588
LEU A 549
MET A 578
VAL A 256
LEU A 158
 None
 1.24A 3b0wA-5lp4A:
undetectable		 3b0wA-5lp4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC

(Pseudomonas
protegens) 		no annotation 5 CYH C 112
ALA C  34
MET C  43
ALA C  41
VAL C   9
 None
 1.26A 3b0wA-5mg5C:
undetectable		 3b0wA-5mg5C:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 GLN B 184
LEU B 199
ALA B 189
CYH A 380
LEU A 377
 None
 1.26A 3b0wA-5nd1B:
undetectable		 3b0wA-5nd1B:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 GLN B 184
LEU B 199
PHE A 431
CYH A 380
LEU A 377
 None
 1.27A 3b0wA-5nd1B:
undetectable		 3b0wA-5nd1B:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0l N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 LEU A 255
LEU A 437
ALA A 396
ALA A 409
VAL A 431
 None
 1.29A 3b0wA-5u0lA:
undetectable		 3b0wA-5u0lA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsl RADICAL S-ADENOSYL
METHIONINE
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		5 LEU A 148
LEU A 150
ALA A 106
VAL A  76
PHE A 311
 None
 1.04A 3b0wA-5vslA:
undetectable		 3b0wA-5vslA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 5 LEU A 435
LEU A 439
ALA A 410
ALA A 477
VAL A 468
 None
 1.21A 3b0wA-5w1eA:
undetectable		 3b0wA-5w1eA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhi PROTEIN YIIM

(Escherichia
coli) 		no annotation 5 LEU A 191
LEU A 197
ALA A 175
VAL A 113
HIS A  64
 None
 1.29A 3b0wA-5yhiA:
undetectable		 3b0wA-5yhiA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar2 SARCOLEMMAL
MEMBRANE-ASSOCIATED
PROTEIN

(Homo sapiens) 		no annotation 5 ALA A   6
PHE A  17
CYH A  48
LEU A  51
HIS A  55
 None
 1.30A 3b0wA-6ar2A:
undetectable		 3b0wA-6ar2A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4c -

(-) 		no annotation 5 LEU A  93
LEU A  95
ALA A  53
VAL A  23
PHE A 254
 None
 0.98A 3b0wA-6b4cA:
undetectable		 3b0wA-6b4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5c KATANIN P60
ATPASE-CONTAINING
SUBUNIT A-LIKE 1

(Homo sapiens) 		no annotation 5 LEU A 245
ALA A 356
VAL A 354
PHE A 293
LEU A 194
 None
 1.18A 3b0wA-6b5cA:
undetectable		 3b0wA-6b5cA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 LEU H 258
ALA H 326
ALA H 361
VAL H 359
PHE H 306
 None
 1.25A 3b0wA-6chsH:
undetectable		 3b0wA-6chsH:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 5 ALA G 408
ALA G 401
VAL G 433
CYH G 479
LEU G 459
 None
 1.24A 3b0wA-6criG:
undetectable		 3b0wA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et9 ACETYL-COA
ACETYLTRANSFERASE
THIOLASE

(Methanothermococcus
thermolithotrophicus) 		no annotation 5 LEU A  73
ALA A 215
ALA A  71
PHE A  22
LEU A  17
 None
 1.14A 3b0wA-6et9A:
undetectable		 3b0wA-6et9A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 621
MET A 650
ALA A 649
VAL A 646
LEU A 676
 None
 1.25A 3b0wA-6f8zA:
undetectable		 3b0wA-6f8zA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		3 TRP A 299
VAL A 364
ARG A 370
 None
 0.92A 3b0wA-1b1yA:
0.0		 3b0wA-1b1yA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dle COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin) 		3 TRP A 237
VAL A  66
ARG A  81
 None
 0.87A 3b0wA-1dleA:
0.0		 3b0wA-1dleA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fo0 PROTEIN (BM3.3 T
CELL RECEPTOR
BETA-CHAIN)

(Mus musculus) 		PF07686
(V-set) 		3 TRP B  34
VAL B  13
ARG B  15
 None
 0.93A 3b0wA-1fo0B:
0.0		 3b0wA-1fo0B:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxm GAMMA-DELTA T-CELL
RECEPTOR

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TRP A  37
VAL A  13
ARG A 120
 None
 0.95A 3b0wA-1hxmA:
0.0		 3b0wA-1hxmA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jft PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		3 TRP A 215
VAL A 331
ARG A 328
 None
 0.73A 3b0wA-1jftA:
0.0		 3b0wA-1jftA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 TRP A 183
VAL A 367
ARG A 364
 None
 0.85A 3b0wA-1knrA:
0.0		 3b0wA-1knrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ni6 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		3 TRP A 101
VAL A 115
ARG A 113
 None
 0.98A 3b0wA-1ni6A:
0.0		 3b0wA-1ni6A:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nq7 NUCLEAR RECEPTOR
ROR-BETA

(Rattus
norvegicus) 		PF00104
(Hormone_recep) 		3 TRP A 259
VAL A 303
ARG A 309
 None
ARL  A 800 ( 4.7A)
ARL  A 800 ( 4.9A)
 0.71A 3b0wA-1nq7A:
28.5		 3b0wA-1nq7A:
49.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 TRP A  46
VAL A  96
ARG A 222
 None
 0.71A 3b0wA-1ovmA:
0.0		 3b0wA-1ovmA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		3 TRP A 271
VAL A 135
ARG A 142
 None
 0.67A 3b0wA-1sqhA:
undetectable		 3b0wA-1sqhA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09152
(DUF1937) 		3 TRP A  65
VAL A  39
ARG A   2
 None
 0.98A 3b0wA-1t1jA:
undetectable		 3b0wA-1t1jA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywq NITROREDUCTASE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		3 TRP A 170
VAL A 136
ARG A  15
 None
 0.69A 3b0wA-1ywqA:
undetectable		 3b0wA-1ywqA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1z UDP-GLUCOSE
FLAVONOID 3-O
GLYCOSYLTRANSFERASE

(Vitis vinifera) 		PF00201
(UDPGT) 		3 TRP A 264
VAL A 364
ARG A 426
 None
 0.96A 3b0wA-2c1zA:
undetectable		 3b0wA-2c1zA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		3 TRP A 120
VAL A  82
ARG A  90
 None
 0.75A 3b0wA-2cevA:
undetectable		 3b0wA-2cevA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csg PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07350
(DUF1479) 		3 TRP A 212
VAL A 279
ARG A  85
 None
 0.94A 3b0wA-2csgA:
undetectable		 3b0wA-2csgA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbn HYPOTHETICAL PROTEIN
YBIU

(Escherichia
coli) 		PF07350
(DUF1479) 		3 TRP A 212
VAL A 279
ARG A  85
 None
 0.88A 3b0wA-2dbnA:
undetectable		 3b0wA-2dbnA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 TRP B 648
VAL B 564
ARG B 456
 None
 0.98A 3b0wA-2fffB:
undetectable		 3b0wA-2fffB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 TRP B 712
VAL B 422
ARG B 419
 None
 0.80A 3b0wA-2fffB:
undetectable		 3b0wA-2fffB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmc DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		3 TRP A 308
VAL A 201
ARG A 173
 None
 0.95A 3b0wA-2hmcA:
undetectable		 3b0wA-2hmcA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3e T7I23.11 PROTEIN

(Arabidopsis
thaliana) 		PF04548
(AIG1) 		3 TRP A 229
VAL A 119
ARG A 245
 None
 0.93A 3b0wA-2j3eA:
undetectable		 3b0wA-2j3eA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkq MYOTILIN

(Homo sapiens) 		PF07679
(I-set) 		3 TRP A  49
VAL A  27
ARG A 110
 None
 0.66A 3b0wA-2kkqA:
undetectable		 3b0wA-2kkqA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5f PUTATIVE NUDIX
HYDROLASE DR_0079

(Deinococcus
radiodurans) 		PF00293
(NUDIX) 		3 TRP A  99
VAL A  72
ARG A  24
 None
 0.92A 3b0wA-2o5fA:
undetectable		 3b0wA-2o5fA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvk YJHT

(Escherichia
coli) 		PF01344
(Kelch_1) 		3 TRP A  98
VAL A 311
ARG A 307
 None
 0.84A 3b0wA-2uvkA:
undetectable		 3b0wA-2uvkA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 TRP A  45
VAL A  95
ARG A 224
 None
 0.86A 3b0wA-2vk4A:
undetectable		 3b0wA-2vk4A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vyc BIODEGRADATIVE
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		3 TRP A 350
VAL A 586
ARG A 588
 PLP  A1386 (-4.0A)
None
None
 0.88A 3b0wA-2vycA:
undetectable		 3b0wA-2vycA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		3 TRP A1592
VAL A1547
ARG A1523
 None
 0.95A 3b0wA-2vz9A:
undetectable		 3b0wA-2vz9A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 TRP A 277
VAL A 111
ARG A 148
 None
 0.88A 3b0wA-2wd9A:
undetectable		 3b0wA-2wd9A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF07679
(I-set) 		3 TRP A 168
VAL A 146
ARG A 228
 None
 0.92A 3b0wA-2yd3A:
undetectable		 3b0wA-2yd3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yl2 ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 TRP A 246
VAL A 542
ARG A 604
 None
 0.94A 3b0wA-2yl2A:
undetectable		 3b0wA-2yl2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		3 TRP A 401
VAL A 433
ARG A 480
 None
 0.86A 3b0wA-2yn9A:
undetectable		 3b0wA-2yn9A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp. JT-ISH-224) 		PF11477
(PM0188) 		3 TRP A 282
VAL A 222
ARG A 193
 None
 0.91A 3b0wA-2z4tA:
undetectable		 3b0wA-2z4tA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		3 TRP A 501
VAL A 437
ARG A 433
 None
 0.80A 3b0wA-2zpaA:
undetectable		 3b0wA-2zpaA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 TRP A 179
VAL A  49
ARG A  47
 None
 0.97A 3b0wA-3a5kA:
undetectable		 3b0wA-3a5kA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 3 TRP E  97
VAL E  31
ARG E 413
 None
 0.92A 3b0wA-3aoeE:
undetectable		 3b0wA-3aoeE:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da0 CLEAVED CHIMERIC
RECEPTOR BINDING
PROTEIN FROM
BACTERIOPHAGES
TP901-1 AND P2

(Lactococcus
phage TP901-1;
Lactococcus
virus P2) 		PF08931
(Caudo_bapla_RBP) 		3 TRP A 144
VAL A 109
ARG A 111
 None
 0.89A 3b0wA-3da0A:
undetectable		 3b0wA-3da0A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhu ALPHA-AMYLASE

(Lactobacillus
plantarum) 		PF00128
(Alpha-amylase) 		3 TRP A 243
VAL A 335
ARG A  37
 None
 0.97A 3b0wA-3dhuA:
undetectable		 3b0wA-3dhuA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A  53
VAL A 150
ARG A 148
 None
 0.91A 3b0wA-3eezA:
undetectable		 3b0wA-3eezA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9c METHIONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF09334
(tRNA-synt_1g) 		3 TRP A 512
VAL A 389
ARG A 395
 None
 0.92A 3b0wA-3h9cA:
undetectable		 3b0wA-3h9cA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4y CATECHOL
1,2-DIOXYGENASE

(Rhodococcus
opacus) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		3 TRP A 154
VAL A 138
ARG A 185
 None
 0.91A 3b0wA-3i4yA:
undetectable		 3b0wA-3i4yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j23 CAPSID PROTEIN VP1

(Enterovirus A) 		PF00073
(Rhv) 		3 TRP A 109
VAL A 123
ARG A 264
 None
 0.76A 3b0wA-3j23A:
undetectable		 3b0wA-3j23A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 TRP A 362
VAL A 383
ARG A 381
 None
 0.96A 3b0wA-3k92A:
undetectable		 3b0wA-3k92A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwj ATSK2

(Arabidopsis
thaliana) 		PF01202
(SKI) 		3 TRP A 240
VAL A 268
ARG A 266
 None
 0.91A 3b0wA-3nwjA:
undetectable		 3b0wA-3nwjA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2i DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TRP A 179
VAL A 194
ARG A 134
 None
 0.74A 3b0wA-3q2iA:
undetectable		 3b0wA-3q2iA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TRP A 178
VAL A 193
ARG A 133
 None
 0.82A 3b0wA-3q2kA:
undetectable		 3b0wA-3q2kA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5e TRANSALDOLASE

(Corynebacterium
glutamicum) 		PF00923
(TAL_FSA) 		3 TRP A  15
VAL A 174
ARG A 172
 None
 0.98A 3b0wA-3r5eA:
undetectable		 3b0wA-3r5eA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		3 TRP A 325
VAL A 372
ARG A 370
 None
 0.93A 3b0wA-3s6hA:
undetectable		 3b0wA-3s6hA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up1 INTERLEUKIN-7
RECEPTOR SUBUNIT
ALPHA

(Homo sapiens) 		PF00041
(fn3) 		3 TRP A 158
VAL A 117
ARG A 120
 None
None
GOL  A 906 ( 4.5A)
 0.78A 3b0wA-3up1A:
undetectable		 3b0wA-3up1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		3 TRP A 256
VAL A 295
ARG A 302
 None
 0.84A 3b0wA-3vilA:
undetectable		 3b0wA-3vilA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zys DYNAMIN-1

(Homo sapiens) 		PF00169
(PH) 		3 TRP C 108
VAL C  88
ARG C  86
 None
 0.69A 3b0wA-3zysC:
undetectable		 3b0wA-3zysC:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		3 TRP A 458
VAL A 305
ARG A 333
 None
 0.88A 3b0wA-4aahA:
undetectable		 3b0wA-4aahA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak2 BT_4661

(Bacteroides
thetaiotaomicron) 		PF16319
(DUF4958) 		3 TRP A 612
VAL A 554
ARG A 558
 None
 0.97A 3b0wA-4ak2A:
undetectable		 3b0wA-4ak2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn7 COPPER INDUCED
NITROREDUCTASE D

(Lactococcus
lactis) 		PF00881
(Nitroreductase) 		3 TRP A 171
VAL A 137
ARG A  10
 None
None
FMN  A 504 (-3.0A)
 0.83A 3b0wA-4bn7A:
undetectable		 3b0wA-4bn7A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE

(Escherichia
coli) 		PF00378
(ECH_1) 		3 TRP A 166
VAL A  53
ARG A  41
 None
 0.75A 3b0wA-4elxA:
undetectable		 3b0wA-4elxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		3 TRP A   3
VAL A 120
ARG A 183
 None
AZM  A 302 ( 4.8A)
None
 0.78A 3b0wA-4g7aA:
undetectable		 3b0wA-4g7aA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hq6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 TRP A 351
VAL A 648
ARG A 710
 None
 0.93A 3b0wA-4hq6A:
undetectable		 3b0wA-4hq6A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hv6 TRANSCRIPTIONAL
REGULATOR MNTR

(Bacillus
subtilis) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 TRP A 107
VAL A 117
ARG A 126
 None
 0.85A 3b0wA-4hv6A:
undetectable		 3b0wA-4hv6A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvt POST-PROLINE
CLEAVING ENZYME

(Rickettsia
typhi) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 TRP A 504
VAL A 572
ARG A 535
 None
 0.89A 3b0wA-4hvtA:
undetectable		 3b0wA-4hvtA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ibn RIBONUCLEASE H

(uncultured
organism) 		PF00075
(RNase_H) 		3 TRP A 111
VAL A 136
ARG A  88
 None
 0.98A 3b0wA-4ibnA:
undetectable		 3b0wA-4ibnA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana) 		PF00491
(Arginase) 		3 TRP A 135
VAL A  97
ARG A 105
 None
 0.75A 3b0wA-4iu4A:
undetectable		 3b0wA-4iu4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnt ENVELOPE
GLYCOPROTEIN E2

(Pestivirus A) 		PF16329
(Pestivirus_E2) 		3 TRP A 879
VAL A 830
ARG A 846
 NAG  A2401 (-3.6A)
None
None
 0.93A 3b0wA-4jntA:
undetectable		 3b0wA-4jntA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Mycobacterium
avium) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		3 TRP A 441
VAL A 230
ARG A 228
 None
 0.85A 3b0wA-4lgvA:
undetectable		 3b0wA-4lgvA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		3 TRP A 556
VAL A 224
ARG A 199
 None
 0.70A 3b0wA-4nj5A:
undetectable		 3b0wA-4nj5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofd KIN OF IRRE-LIKE
PROTEIN 1

(Mus musculus) 		PF07679
(I-set)
PF08205
(C2-set_2) 		3 TRP A  57
VAL A 120
ARG A 182
 None
 0.91A 3b0wA-4ofdA:
undetectable		 3b0wA-4ofdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q82 PHOSPHOLIPASE/CARBOX
YLESTERASE

(Haliangium
ochraceum) 		no annotation 3 TRP A 286
VAL A 140
ARG A  67
 None
 0.97A 3b0wA-4q82A:
undetectable		 3b0wA-4q82A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd4 HEME OXYGENASE 1

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		3 TRP A 101
VAL A 115
ARG A 113
 None
 0.85A 3b0wA-4wd4A:
undetectable		 3b0wA-4wd4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		3 TRP A 737
VAL A 962
ARG A 972
 None
 0.96A 3b0wA-4wd9A:
undetectable		 3b0wA-4wd9A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		3 TRP A 404
VAL A 348
ARG A 318
 None
 0.75A 3b0wA-4wk7A:
undetectable		 3b0wA-4wk7A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		3 TRP A 330
VAL A 398
ARG A 343
 None
 0.91A 3b0wA-4xprA:
undetectable		 3b0wA-4xprA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 TRP A 148
VAL A 216
ARG A 208
 None
 0.97A 3b0wA-4ywoA:
undetectable		 3b0wA-4ywoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 TRP A 312
VAL A 382
ARG A 410
 None
 0.89A 3b0wA-4zmhA:
undetectable		 3b0wA-4zmhA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 TRP A 245
VAL A 288
ARG A 286
 GOL  A 301 (-4.3A)
None
None
 0.87A 3b0wA-4zrsA:
undetectable		 3b0wA-4zrsA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxk SIALIDASE A

(Streptococcus
pneumoniae) 		PF02973
(Sialidase) 		3 TRP A 280
VAL A 154
ARG A 304
 None
 0.75A 3b0wA-4zxkA:
undetectable		 3b0wA-4zxkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 TRP A 612
VAL A 592
ARG A 590
 None
 0.83A 3b0wA-5a3fA:
undetectable		 3b0wA-5a3fA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN

(Coprinopsis
cinerea) 		PF03664
(Glyco_hydro_62) 		3 TRP A 340
VAL A 121
ARG A 118
 None
 0.97A 3b0wA-5b6tA:
undetectable		 3b0wA-5b6tA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp3 MYCOCEROSIC ACID
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF14765
(PS-DH) 		3 TRP A 930
VAL A 998
ARG A1006
 None
 0.86A 3b0wA-5bp3A:
undetectable		 3b0wA-5bp3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		3 TRP A 108
VAL A  31
ARG A 732
 None
 0.87A 3b0wA-5bptA:
undetectable		 3b0wA-5bptA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwd BENZYLSUCCINATE
SYNTHASE ALPHA CHAIN

(Thauera
aromatica) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 TRP A 488
VAL A 444
ARG A 442
 None
 0.86A 3b0wA-5bwdA:
undetectable		 3b0wA-5bwdA:
14.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 TRP A 317
VAL A 361
ARG A 367
 None
 0.40A 3b0wA-5c4tA:
33.4		 3b0wA-5c4tA:
99.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfe EXODEOXYRIBONUCLEASE

(Bacillus
subtilis) 		PF03372
(Exo_endo_phos) 		3 TRP A 201
VAL A  14
ARG A  12
 None
 0.95A 3b0wA-5cfeA:
undetectable		 3b0wA-5cfeA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1)
PF00603
(Flu_PA) 		3 TRP A 388
VAL A 399
ARG B 550
 None
 0.86A 3b0wA-5d9aA:
undetectable		 3b0wA-5d9aA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		3 TRP A 141
VAL A 614
ARG A 689
 None
 0.87A 3b0wA-5dkxA:
undetectable		 3b0wA-5dkxA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fll 6-CARBOXYHEXANOATE-C
OA LIGASE

(Bacillus
subtilis) 		PF03744
(BioW) 		3 TRP A 119
VAL A 204
ARG A 213
 None
None
WAQ  A 700 (-3.8A)
 0.97A 3b0wA-5fllA:
undetectable		 3b0wA-5fllA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		3 TRP A 244
VAL A  73
ARG A  80
 None
 0.94A 3b0wA-5gkvA:
undetectable		 3b0wA-5gkvA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 3 TRP B 178
VAL B 216
ARG B 218
 None
 0.93A 3b0wA-5hzgB:
undetectable		 3b0wA-5hzgB:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		3 TRP A 540
VAL A 603
ARG A 599
 None
 0.91A 3b0wA-5ijlA:
undetectable		 3b0wA-5ijlA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jri PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 3 TRP A 270
VAL A 108
ARG A 123
 SO4  A 407 (-3.4A)
None
None
 0.89A 3b0wA-5jriA:
undetectable		 3b0wA-5jriA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 3 TRP A 472
VAL A 399
ARG A 160
 None
None
GOL  A 654 (-4.0A)
 0.60A 3b0wA-5jvkA:
undetectable		 3b0wA-5jvkA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9n POLYAMINE N
ACETYLTRANSFERASE

(Drosophila
melanogaster) 		PF00583
(Acetyltransf_1) 		3 TRP A 100
VAL A 209
ARG A 187
 None
 0.93A 3b0wA-5k9nA:
undetectable		 3b0wA-5k9nA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		3 TRP A 263
VAL A 568
ARG A 478
 None
 0.96A 3b0wA-5lrbA:
undetectable		 3b0wA-5lrbA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 3 TRP A 544
VAL A 448
ARG A 456
 None
 0.92A 3b0wA-5ogsA:
undetectable		 3b0wA-5ogsA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		3 TRP A 362
VAL A  44
ARG A  70
 None
 0.81A 3b0wA-5ti8A:
undetectable		 3b0wA-5ti8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN J
TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa) 		no annotation 3 TRP X  48
VAL W 111
ARG W 123
 None
 0.96A 3b0wA-5vtmX:
undetectable		 3b0wA-5vtmX:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 3 TRP A 256
VAL A 134
ARG A 136
 None
 0.86A 3b0wA-5xj1A:
undetectable		 3b0wA-5xj1A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		3 TRP A 217
VAL A  85
ARG A 394
 None
 0.90A 3b0wA-5xjjA:
undetectable		 3b0wA-5xjjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6al5 B-LYMPHOCYTE ANTIGEN
CD19

(Homo sapiens) 		no annotation 3 TRP A  52
VAL A  28
ARG A 277
 None
 0.76A 3b0wA-6al5A:
undetectable		 3b0wA-6al5A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axf RAS GUANYL-RELEASING
PROTEIN 2

(Homo sapiens) 		no annotation 3 TRP A 206
VAL A 354
ARG A 351
 None
 0.82A 3b0wA-6axfA:
undetectable		 3b0wA-6axfA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 3 TRP A 364
VAL A 179
ARG A 169
 None
 0.91A 3b0wA-6bk1A:
undetectable		 3b0wA-6bk1A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum) 		no annotation 3 TRP A 346
VAL A 429
ARG A 459
 None
 0.88A 3b0wA-6cddA:
undetectable		 3b0wA-6cddA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE
ALPHA SUBUNIT

(Rhodococcus
jostii) 		no annotation 3 TRP A  29
VAL A 132
ARG A 134
 F8G  B 302 ( 4.6A)
None
None
 0.85A 3b0wA-6co9A:
undetectable		 3b0wA-6co9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN

(Streptococcus
pyogenes;
Vibrio cholerae) 		no annotation 3 TRP A 870
VAL A 787
ARG A 830
 None
 0.98A 3b0wA-6en3A:
undetectable		 3b0wA-6en3A:
17.99