SIMILAR PATTERNS OF AMINO ACIDS FOR 3AXZ_A_ADNA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 GLY A 203
GLY A 222
ILE A 119
LEU A 129
GLY A 128
 None
 0.82A 3axzA-1do5A:
undetectable		 3axzA-1do5A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dub 2-ENOYL-COA
HYDRATASE

(Rattus
norvegicus) 		PF00378
(ECH_1) 		5 GLY A 175
ILE A  66
LEU A 145
GLY A 142
GLY A 141
 None
None
None
None
CAA  A 300 (-3.6A)
 1.01A 3axzA-1dubA:
0.3		 3axzA-1dubA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  12
GLY A  16
ILE A  95
GLY A  40
GLY A  39
 FAD  A 451 ( 4.9A)
None
None
FAD  A 451 (-3.2A)
None
 1.01A 3axzA-1geuA:
0.0		 3axzA-1geuA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 LEU A 156
PRO A 165
GLY A 154
GLY A 169
ILE A 263
 None
 0.98A 3axzA-1gqrA:
0.0		 3axzA-1gqrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 235
ILE A 461
LEU A  65
GLY A  87
GLY A  86
 None
 1.01A 3axzA-1jcnA:
0.0		 3axzA-1jcnA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 SER A 276
GLY A 326
GLY A 340
SER A 275
GLY A 324
 MOA  A1332 (-2.6A)
MOA  A1332 ( 3.5A)
None
None
None
 0.94A 3axzA-1jr1A:
0.0		 3axzA-1jr1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		5 LEU A  72
GLY A 103
GLY A 107
SER A 121
LEU A 127
 None
 0.66A 3axzA-1ns5A:
9.4		 3axzA-1ns5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oj4 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Escherichia
coli) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A 105
GLY A 107
SER A 178
ILE A 179
GLY A 103
 ANP  A1285 (-2.6A)
ANP  A1285 (-3.2A)
None
None
ANP  A1285 (-3.0A)
 1.01A 3axzA-1oj4A:
0.0		 3axzA-1oj4A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oy5 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Aquifex
aeolicus) 		PF01746
(tRNA_m1G_MT) 		5 GLY A 115
GLY A 119
LEU A 139
GLY A 141
GLY A 142
 None
 0.55A 3axzA-1oy5A:
21.3		 3axzA-1oy5A:
36.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		6 LEU A  87
SER A  88
PRO A  89
SER A 132
GLY A 113
GLY A 141
 SAH  A 300 (-4.4A)
None
SAH  A 300 (-3.8A)
SAH  A 300 (-3.6A)
SAH  A 300 (-3.2A)
SAH  A 300 (-3.5A)
 1.45A 3axzA-1p9pA:
14.1		 3axzA-1p9pA:
78.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p9p TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF01746
(tRNA_m1G_MT) 		12 TYR A  86
LEU A  87
SER A  88
PRO A  89
GLY A 113
GLY A 117
SER A 132
ILE A 133
LEU A 138
GLY A 140
GLY A 141
PRO A 144
 SAH  A 300 (-4.4A)
SAH  A 300 (-4.4A)
None
SAH  A 300 (-3.8A)
SAH  A 300 (-3.2A)
SAH  A 300 (-3.6A)
SAH  A 300 (-3.6A)
SAH  A 300 (-4.4A)
SAH  A 300 (-4.1A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.5A)
SAH  A 300 (-4.5A)
 0.33A 3axzA-1p9pA:
14.1		 3axzA-1p9pA:
78.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz9 MANNONATE
DEHYDRATASE

(Enterococcus
faecalis) 		PF03786
(UxuA) 		5 GLY A 330
GLY A 319
ILE A  20
LEU A 333
GLY A 332
 None
 0.93A 3axzA-1tz9A:
undetectable		 3axzA-1tz9A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		5 PRO A 167
GLY A  81
GLY A  51
ILE A 114
GLY A  77
 None
None
CL  A1202 ( 3.7A)
SNN  A 112 ( 4.2A)
None
 1.04A 3axzA-1wl8A:
undetectable		 3axzA-1wl8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 156
GLY A 162
ILE A 218
LEU A 177
GLY A 178
 NAP  A 801 ( 3.1A)
CL  A 816 (-3.3A)
None
None
None
 0.90A 3axzA-1yb5A:
undetectable		 3axzA-1yb5A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  15
GLY A  42
ILE A 336
GLY A  18
GLY A  17
 FAD  A4750 (-3.7A)
None
None
None
FAD  A4750 (-3.6A)
 1.09A 3axzA-1zy8A:
undetectable		 3axzA-1zy8A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		5 PRO A 168
GLY A  82
GLY A  50
ILE A 115
GLY A  78
 None
 1.01A 3axzA-2a9vA:
undetectable		 3axzA-2a9vA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		5 SER A  52
ILE A  46
LEU A 102
GLY A 103
GLY A 106
 None
 1.10A 3axzA-2amgA:
undetectable		 3axzA-2amgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmo OXYGENASE-ALPHA NBDO

(Comamonas sp.
JS765) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 GLY A 204
SER A 292
ILE A 289
LEU A 238
GLY A 249
 None
 1.10A 3axzA-2bmoA:
undetectable		 3axzA-2bmoA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		5 LEU A 196
GLY A 326
GLY A 358
GLY A 198
GLY A 197
 None
 1.06A 3axzA-2cunA:
2.1		 3axzA-2cunA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1y HYPOTHETICAL PROTEIN
TT0321

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 LEU A  35
GLY A  13
ILE A  49
GLY A  19
GLY A  14
 None
NAD  A1001 (-3.5A)
None
None
None
 0.95A 3axzA-2d1yA:
undetectable		 3axzA-2d1yA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfj DIADENOSINETETRAPHOS
PHATASE

(Shigella
flexneri) 		PF00149
(Metallophos) 		5 LEU A 231
SER A 230
GLY A 246
SER A 199
GLY A 233
 None
 0.73A 3axzA-2dfjA:
undetectable		 3axzA-2dfjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 SER A 451
PRO A 452
GLY A 448
GLY A 446
GLY A 444
 None
 0.93A 3axzA-2dpnA:
undetectable		 3axzA-2dpnA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh6 ACETYLORNITHINE
AMINOTRANSFERASE

(Aquifex
aeolicus) 		PF00202
(Aminotran_3) 		5 LEU A  42
GLY A 242
GLY A  38
GLY A 246
GLY A 245
 None
 0.92A 3axzA-2eh6A:
undetectable		 3axzA-2eh6A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8s GLUCOSE/SORBOSONE
DEHYDROGENASES

(Escherichia
coli) 		PF07995
(GSDH) 		5 GLY A 145
GLY A 129
ILE A 188
LEU A 159
GLY A 161
 None
 0.95A 3axzA-2g8sA:
undetectable		 3axzA-2g8sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		5 PRO A 136
GLY A 216
SER A 157
GLY A 192
GLY A 191
 None
DFP  A1189 (-3.6A)
None
None
None
 0.71A 3axzA-2gzsA:
undetectable		 3axzA-2gzsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 SER A 470
GLY A 439
GLY A 465
ILE A 476
GLY A 441
 None
None
TPP  A 600 (-3.5A)
None
None
 0.93A 3axzA-2ihtA:
undetectable		 3axzA-2ihtA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2

(Homo sapiens) 		PF00428
(Ribosomal_60s) 		5 LEU B 112
GLY A  36
ILE B 151
GLY B 114
GLY B 113
 None
 0.94A 3axzA-2lbfB:
undetectable		 3axzA-2lbfB:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbw H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF01248
(Ribosomal_L7Ae) 		5 LEU A 110
GLY A 114
SER A 121
ILE A  81
GLY A 111
 None
 0.99A 3axzA-2lbwA:
undetectable		 3axzA-2lbwA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 LEU A 343
GLY A 348
GLY A 383
SER A 315
GLY A 323
 None
 0.85A 3axzA-2odlA:
undetectable		 3axzA-2odlA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 GLY A 244
GLY A 206
LEU A 210
GLY A 246
PRO A 256
 None
 1.08A 3axzA-2p3eA:
undetectable		 3axzA-2p3eA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		5 GLY A 420
GLY A 467
SER A 324
ILE A 334
GLY A 373
 None
 1.03A 3axzA-2vpjA:
undetectable		 3axzA-2vpjA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhg CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF07632
(DUF1593) 		5 LEU A 745
GLY A 762
GLY A 765
GLY A 764
PRO A 742
 None
MG  A1939 (-3.9A)
MG  A1939 (-3.8A)
None
None
 1.06A 3axzA-2yhgA:
undetectable		 3axzA-2yhgA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  10
GLY A  37
ILE A 318
GLY A  13
GLY A  12
 FAD  A1601 (-3.5A)
None
None
None
FAD  A1601 (-3.6A)
 1.00A 3axzA-2yquA:
undetectable		 3axzA-2yquA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 5 PRO A 411
GLY A  65
GLY A  63
SER A 653
GLY A 118
 FAD  A 801 (-4.2A)
FAD  A 801 (-3.6A)
FAD  A 801 (-3.1A)
None
FAD  A 801 (-3.2A)
 1.07A 3axzA-2yr5A:
undetectable		 3axzA-2yr5A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 GLY A 524
GLY A 631
LEU A 651
GLY A 655
GLY A 654
 None
 1.07A 3axzA-3a24A:
undetectable		 3axzA-3a24A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab1 FERREDOXIN--NADP
REDUCTASE

(Chlorobaculum
tepidum) 		PF07992
(Pyr_redox_2) 		5 GLY A  22
GLY A  26
ILE A  74
GLY A  51
GLY A  50
 FAD  A 361 ( 4.7A)
None
None
FAD  A 361 (-3.0A)
None
 1.00A 3axzA-3ab1A:
undetectable		 3axzA-3ab1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai9 UPF0217 PROTEIN
MJ1640

(Methanocaldococcus
jannaschii) 		PF04013
(Methyltrn_RNA_2) 		5 TYR X 135
LEU X 136
GLY X 156
SER X 178
LEU X 184
 None
SAM  X 501 (-4.3A)
SAM  X 501 (-3.2A)
SAM  X 501 ( 3.7A)
SAM  X 501 (-4.3A)
 0.59A 3axzA-3ai9X:
8.4		 3axzA-3ai9X:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 3

(Schizosaccharomyces
pombe) 		PF00022
(Actin) 		5 GLY A 187
GLY A 213
LEU A 338
GLY A 335
GLY A 334
 ATP  A 428 (-3.2A)
ATP  A 428 (-3.7A)
ATP  A 428 ( 3.8A)
ATP  A 428 (-3.2A)
ATP  A 428 (-3.8A)
 1.08A 3axzA-3dwlA:
undetectable		 3axzA-3dwlA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehe UDP-GLUCOSE
4-EPIMERASE (GALE-1)

(Archaeoglobus
fulgidus) 		PF01370
(Epimerase) 		5 GLY A  11
GLY A  36
ILE A  27
GLY A   8
GLY A   9
 NAD  A 900 (-3.3A)
NAD  A 900 (-3.0A)
None
NAD  A 900 (-3.6A)
None
 1.08A 3axzA-3eheA:
undetectable		 3axzA-3eheA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezo MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Burkholderia
pseudomallei) 		PF00698
(Acyl_transf_1) 		5 PRO A 190
GLY A 168
GLY A 172
GLY A 127
GLY A 128
 None
 1.03A 3axzA-3ezoA:
undetectable		 3axzA-3ezoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ftb HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Clostridium
acetobutylicum) 		PF00155
(Aminotran_1_2) 		5 GLY A  86
ILE A  70
LEU A  83
GLY A  84
GLY A 225
 PO4  A 362 (-3.4A)
None
None
None
None
 0.87A 3axzA-3ftbA:
undetectable		 3axzA-3ftbA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fys PROTEIN DEGV

(Bacillus
subtilis) 		PF02645
(DegV) 		5 TYR A  49
GLY A 270
GLY A 266
LEU A 274
GLY A 272
 None
 0.77A 3axzA-3fysA:
undetectable		 3axzA-3fysA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzy RTX TOXIN RTXA

(Vibrio cholerae) 		PF11713
(Peptidase_C80) 		5 SER A3569
GLY A3580
GLY A3578
SER A3568
LEU A3531
 None
 1.10A 3axzA-3fzyA:
undetectable		 3axzA-3fzyA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 LEU A 399
PRO A 401
GLY A 420
GLY A 376
GLY A 377
 None
 1.02A 3axzA-3g5sA:
undetectable		 3axzA-3g5sA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyq RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE

(Streptomyces
cyaneus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		5 LEU A 195
GLY A 218
GLY A 223
SER A 237
ILE A 238
 SAM  A 270 (-4.1A)
SAM  A 270 (-2.9A)
None
SAM  A 270 (-4.3A)
SAM  A 270 (-3.5A)
 0.69A 3axzA-3gyqA:
7.7		 3axzA-3gyqA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME

(Corynebacterium
glutamicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 305
SER A 304
GLY A 307
GLY A 310
GLY A 332
 LEU  A 305 ( 0.6A)
SER  A 304 ( 0.0A)
GLY  A 307 ( 0.0A)
GLY  A 310 ( 0.0A)
GLY  A 332 ( 0.0A)
 0.95A 3axzA-3i4kA:
undetectable		 3axzA-3i4kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		5 GLY 1 324
GLY 1  67
ILE 1 329
GLY 1 326
GLY 1 293
 None
 1.09A 3axzA-3i9v1:
undetectable		 3axzA-3i9v1:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ief TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Bartonella
henselae) 		PF01746
(tRNA_m1G_MT) 		6 GLY A 111
SER A 130
ILE A 131
LEU A 136
GLY A 138
GLY A 139
 None
 0.59A 3axzA-3iefA:
21.9		 3axzA-3iefA:
43.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ief TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Bartonella
henselae) 		PF01746
(tRNA_m1G_MT) 		7 SER A  86
PRO A  87
SER A 130
ILE A 131
LEU A 136
GLY A 138
GLY A 139
 None
 0.43A 3axzA-3iefA:
21.9		 3axzA-3iefA:
43.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		5 LEU A 229
GLY A 232
LEU A 261
GLY A 260
GLY A 259
 None
 1.00A 3axzA-3kjxA:
4.4		 3axzA-3kjxA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3knu TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Anaplasma
phagocytophilum) 		PF01746
(tRNA_m1G_MT) 		9 SER A  87
PRO A  88
GLY A 112
GLY A 116
SER A 131
ILE A 132
LEU A 137
GLY A 139
GLY A 140
 None
 0.43A 3axzA-3knuA:
24.8		 3axzA-3knuA:
40.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		6 GLY A 111
SER A 130
LEU A 136
GLY A 138
GLY A 139
PRO A 142
 None
OCS  A  86 ( 3.8A)
None
None
None
None
 0.63A 3axzA-3ky7A:
20.6		 3axzA-3ky7A:
44.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ky7 TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Staphylococcus
aureus) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  87
GLY A 111
SER A 130
LEU A 136
GLY A 138
GLY A 139
 OCS  A  86 ( 2.5A)
None
OCS  A  86 ( 3.8A)
None
None
None
 0.64A 3axzA-3ky7A:
20.6		 3axzA-3ky7A:
44.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 GLY A 176
GLY A 152
LEU A 181
GLY A 180
GLY A 178
 None
 0.93A 3axzA-3nd0A:
undetectable		 3axzA-3nd0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgv ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A  53
GLY A  61
SER A  22
GLY A  55
GLY A  56
 None
 1.03A 3axzA-3qgvA:
undetectable		 3axzA-3qgvA:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		6 GLY A 109
GLY A 113
ILE A 133
LEU A 138
GLY A 140
GLY A 141
 EDO  A 244 ( 4.1A)
EDO  A 244 (-3.4A)
None
EDO  A 243 (-4.0A)
EDO  A 243 (-4.1A)
EDO  A 243 (-3.6A)
 0.51A 3axzA-3quvA:
21.8		 3axzA-3quvA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  85
GLY A 109
GLY A 113
ILE A 133
LEU A 138
GLY A 141
 EDO  A 243 (-3.7A)
EDO  A 244 ( 4.1A)
EDO  A 244 (-3.4A)
None
EDO  A 243 (-4.0A)
EDO  A 243 (-3.6A)
 0.78A 3axzA-3quvA:
21.8		 3axzA-3quvA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quv TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Mycobacteroides
abscessus) 		PF01746
(tRNA_m1G_MT) 		6 PRO A  85
GLY A 109
GLY A 113
SER A 132
ILE A 133
GLY A 141
 EDO  A 243 (-3.7A)
EDO  A 244 ( 4.1A)
EDO  A 244 (-3.4A)
None
None
EDO  A 243 (-3.6A)
 0.96A 3axzA-3quvA:
21.8		 3axzA-3quvA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 GLY A  10
GLY A  37
ILE A 120
GLY A 101
GLY A 100
 None
 0.85A 3axzA-3s2uA:
undetectable		 3axzA-3s2uA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 LEU A  99
GLY A  10
GLY A  37
GLY A 101
GLY A 100
 None
 0.97A 3axzA-3s2uA:
undetectable		 3axzA-3s2uA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9j MEMBER OF DUF4221
FAMILY

(Bacteroides
vulgatus) 		PF13970
(DUF4221) 		5 TYR A 217
GLY A 274
ILE A 176
GLY A 223
GLY A 222
 None
None
None
FMT  A 404 ( 3.2A)
GOL  A 416 ( 3.3A)
 1.07A 3axzA-3s9jA:
undetectable		 3axzA-3s9jA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 GLY A  95
SER A  14
ILE A  15
LEU A  90
GLY A  91
 None
 0.82A 3axzA-3tbhA:
undetectable		 3axzA-3tbhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 GLY A 274
GLY A 238
ILE A 355
LEU A 291
GLY A 293
 None
 0.86A 3axzA-3v4pA:
undetectable		 3axzA-3v4pA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		5 LEU A 297
GLY A 259
ILE A  25
LEU A 303
GLY A 302
 None
 1.02A 3axzA-3vglA:
undetectable		 3axzA-3vglA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 LEU A  66
SER A  65
SER A  67
GLY A 324
GLY A 325
 None
 1.01A 3axzA-3wrtA:
undetectable		 3axzA-3wrtA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxm PROTEIN PELOTA
HOMOLOG

(Aeropyrum
pernix) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		5 GLY B 227
GLY B 198
ILE B 151
GLY B 231
GLY B 228
 None
 1.09A 3axzA-3wxmB:
undetectable		 3axzA-3wxmB:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		5 PRO A 204
LEU A 118
GLY A 160
GLY A 161
PRO A 110
 None
 0.97A 3axzA-4ayjA:
undetectable		 3axzA-4ayjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dcm RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G

(Escherichia
coli) 		PF05175
(MTS) 		5 GLY A 240
GLY A 238
ILE A 232
LEU A 303
GLY A 243
 None
SAM  A 401 ( 3.7A)
None
None
None
 0.83A 3axzA-4dcmA:
undetectable		 3axzA-4dcmA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Paraburkholderia
phymatum) 		PF01746
(tRNA_m1G_MT) 		8 SER A  92
PRO A  93
GLY A 117
SER A 136
LEU A 142
GLY A 144
GLY A 145
PRO A 148
 None
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-3.4A)
SAH  A 301 (-4.3A)
SAH  A 301 (-3.1A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.4A)
 0.36A 3axzA-4h3zA:
24.1		 3axzA-4h3zA:
51.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A  24
GLY A  22
ILE A  72
GLY A  98
GLY A  99
 FED  A 801 (-3.3A)
FED  A 801 (-3.3A)
None
None
FED  A 801 (-3.1A)
 0.98A 3axzA-4h7uA:
undetectable		 3axzA-4h7uA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION

(synthetic
construct) 		PF01731
(Arylesterase) 		5 TYR A 207
SER A 209
PRO A 210
ILE A 159
GLY A 174
 None
 0.90A 3axzA-4hhqA:
undetectable		 3axzA-4hhqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhp X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR

(Homo sapiens) 		PF00415
(RCC1) 		5 GLY C 198
GLY C 148
SER C 301
GLY C 252
GLY C 251
 None
 1.05A 3axzA-4jhpC:
undetectable		 3axzA-4jhpC:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmh SUPPRESSOR OF FUSED
HOMOLOG

(Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		5 GLY A 263
GLY A 387
SER A 210
ILE A 219
GLY A 258
 None
 0.99A 3axzA-4kmhA:
undetectable		 3axzA-4kmhA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		5 TYR A 383
ILE A  27
LEU A 375
GLY A 376
GLY A 377
 None
 1.02A 3axzA-4mt1A:
undetectable		 3axzA-4mt1A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhx UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF11958
(DUF3472)
PF16871
(DUF5077) 		5 SER A 123
GLY A 128
GLY A 126
LEU A  94
GLY A 130
 None
CL  A 501 (-4.2A)
CL  A 501 ( 4.9A)
None
None
 1.06A 3axzA-4qhxA:
undetectable		 3axzA-4qhxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 5 GLY A 209
GLY A 186
SER A 224
GLY A 228
GLY A 227
 None
 0.84A 3axzA-4tz5A:
undetectable		 3axzA-4tz5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 154
PRO A 163
GLY A 152
GLY A 167
ILE A 261
 None
 0.91A 3axzA-4xiiA:
undetectable		 3axzA-4xiiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xp8 ETGA PROTEIN

(Escherichia
coli) 		PF01464
(SLT) 		5 LEU A  84
GLY A  62
GLY A  48
SER A  80
ILE A  79
 None
 1.02A 3axzA-4xp8A:
undetectable		 3axzA-4xp8A:
14.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ypw TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Haemophilus
influenzae) 		PF01746
(tRNA_m1G_MT) 		12 TYR A  86
LEU A  87
SER A  88
PRO A  89
GLY A 113
GLY A 117
SER A 132
ILE A 133
LEU A 138
GLY A 140
GLY A 141
PRO A 144
 None
None
None
4FD  A 301 ( 3.6A)
4FD  A 301 (-4.7A)
4FD  A 301 (-3.6A)
4FD  A 301 (-3.2A)
4FD  A 301 (-4.1A)
4FD  A 301 (-3.9A)
4FD  A 301 (-3.6A)
4FD  A 301 (-3.9A)
4FD  A 301 (-4.5A)
 0.31A 3axzA-4ypwA:
31.4		 3axzA-4ypwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  11
GLY A  19
ILE A 151
LEU A  67
GLY A  68
 None
 1.00A 3axzA-5ahkA:
undetectable		 3axzA-5ahkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE

(Escherichia
coli) 		PF01790
(LGT) 		5 GLY A  71
GLY A  75
LEU A 106
GLY A 105
GLY A 108
 PGT  A 309 ( 3.7A)
None
None
BOG  A 303 ( 4.1A)
PGT  A 309 (-3.6A)
 0.81A 3axzA-5azbA:
undetectable		 3axzA-5azbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 326
GLY A 328
ILE A 339
GLY A 332
GLY A 333
 None
 1.02A 3axzA-5c2cA:
undetectable		 3axzA-5c2cA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		5 SER A 391
ILE A 393
LEU A 385
GLY A 382
GLY A 381
 SO4  A 709 (-3.9A)
None
None
None
ZN  A 703 ( 4.8A)
 0.89A 3axzA-5cbmA:
3.3		 3axzA-5cbmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1

(Homo sapiens) 		PF03587
(EMG1) 		5 SER A 177
GLY A 201
SER A 218
ILE A 219
LEU A 224
 CIT  A 302 ( 2.7A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-4.0A)
 0.70A 3axzA-5faiA:
7.5		 3axzA-5faiA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		5 GLY A 179
GLY A 169
ILE A 221
GLY A 182
GLY A 183
 None
None
None
NA  A 403 (-4.6A)
NA  A 403 (-3.9A)
 0.80A 3axzA-5ffnA:
3.5		 3axzA-5ffnA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 LEU B 514
SER B 515
SER B 493
ILE B 494
LEU B 518
 None
 0.99A 3axzA-5hz1B:
undetectable		 3axzA-5hz1B:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 196
GLY A 199
ILE A 165
GLY A 171
GLY A 172
 None
OAS  A 169 ( 3.4A)
None
OAS  A 169 ( 3.8A)
OAS  A 169 ( 3.1A)
 1.09A 3axzA-5jd5A:
undetectable		 3axzA-5jd5A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkx TBPB

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C) 		5 LEU A 587
GLY A 465
ILE A 519
GLY A 589
GLY A 588
 None
 1.08A 3axzA-5kkxA:
undetectable		 3axzA-5kkxA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III

(Rhizobium
freirei) 		PF00202
(Aminotran_3) 		5 LEU A  54
GLY A 268
GLY A  50
GLY A 272
GLY A 271
 None
 0.90A 3axzA-5m49A:
undetectable		 3axzA-5m49A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		5 LEU B  40
SER B  39
PRO B 373
GLY B  47
GLY B 384
 None
 1.09A 3axzA-5m99B:
undetectable		 3axzA-5m99B:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 GLY A  20
GLY A 145
ILE A  87
GLY A   6
GLY A   5
 None
 1.10A 3axzA-5mrrA:
undetectable		 3axzA-5mrrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndl CRH-LIKE PROTEIN

(Aspergillus
fumigatus) 		no annotation 5 LEU A 225
GLY A 105
GLY A 103
GLY A 223
GLY A 224
 None
 0.79A 3axzA-5ndlA:
undetectable		 3axzA-5ndlA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 583
SER A 584
PRO A 585
SER A 606
GLY A 635
 None
 1.02A 3axzA-5nprA:
undetectable		 3axzA-5nprA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		5 GLY A 151
GLY A 155
ILE A 196
GLY A 180
GLY A 179
 FAD  A 701 (-4.5A)
None
None
FAD  A 701 (-3.2A)
None
 0.93A 3axzA-5odrA:
undetectable		 3axzA-5odrA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr3 DIHYDROLIPOYL
DEHYDROGENASE

(Pseudomonas
putida) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  13
GLY A  46
ILE A 335
GLY A  16
GLY A  15
 FAD  A 501 (-3.4A)
None
None
None
FAD  A 501 (-3.8A)
 1.03A 3axzA-5tr3A:
undetectable		 3axzA-5tr3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1o GLUTATHIONE
REDUCTASE

(Vibrio
parahaemolyticus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  16
GLY A  20
ILE A  99
GLY A  44
GLY A  43
 None
None
None
FAD  A 501 (-3.2A)
None
 1.07A 3axzA-5u1oA:
undetectable		 3axzA-5u1oA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 12 TYR A  91
LEU A  92
SER A  93
PRO A  94
GLY A 118
GLY A 122
SER A 137
ILE A 138
LEU A 143
GLY A 145
GLY A 146
PRO A 149
 SFG  A 400 (-4.6A)
SFG  A 400 (-4.6A)
None
SFG  A 400 (-3.7A)
SFG  A 400 (-3.4A)
SFG  A 400 (-3.6A)
SFG  A 400 (-3.3A)
SFG  A 400 (-4.4A)
SFG  A 400 (-4.2A)
SFG  A 400 (-3.2A)
SFG  A 400 (-3.7A)
SFG  A 400 (-4.4A)
 0.35A 3axzA-5wyrA:
24.7		 3axzA-5wyrA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y81 ACTIN-RELATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		no annotation 5 PRO F  41
GLY F  63
SER F  42
ILE F  74
GLY F  45
 None
 1.07A 3axzA-5y81F:
undetectable		 3axzA-5y81F:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 5 GLY D 156
GLY D 206
LEU D 124
GLY D 125
GLY D 126
 None
 1.00A 3axzA-6f45D:
undetectable		 3axzA-6f45D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f45 -

(-) 		no annotation 5 GLY D 167
GLY D 186
SER D 216
GLY D 120
GLY D 158
 None
 1.11A 3axzA-6f45D:
undetectable		 3axzA-6f45D:
undetectable