SIMILAR PATTERNS OF AMINO ACIDS FOR 3AX9_B_SALB1340

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		4 ARG B1712
PHE B1867
ALA B1863
ALA B1864
 None
 0.84A 3ax9B-1a9xB:
0.0		 3ax9B-1a9xB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE

(Human
alphaherpesvirus
2) 		PF00716
(Peptidase_S21) 		4 GLU A  92
LEU A 117
THR A 166
ALA A  18
 None
 0.91A 3ax9B-1at3A:
undetectable		 3ax9B-1at3A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b48 PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 198
SER A 189
ALA A  24
ALA A  25
 None
 0.92A 3ax9B-1b48A:
0.0		 3ax9B-1b48A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		4 GLU A 156
PHE A 296
ALA A 306
ALA A 305
 None
CYN  A   7 ( 4.2A)
None
None
 1.00A 3ax9B-1e08A:
0.0		 3ax9B-1e08A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 292
SER A 295
PHE A 196
ALA A 199
 None
 0.94A 3ax9B-1e1tA:
0.0		 3ax9B-1e1tA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eto FACTOR FOR INVERSION
STIMULATION

(Escherichia
coli) 		PF02954
(HTH_8) 		4 LEU A  63
THR A  87
ALA A  77
ALA A  78
 None
 1.02A 3ax9B-1etoA:
undetectable		 3ax9B-1etoA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		4 LEU A 382
THR A 357
ALA A 390
ALA A 388
 None
 0.92A 3ax9B-1gz5A:
0.0		 3ax9B-1gz5A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igo FAMILY 11 XYLANASE

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11) 		4 LEU A 180
PHE A  36
ALA A 191
ALA A  38
 None
 0.84A 3ax9B-1igoA:
undetectable		 3ax9B-1igoA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 LEU A  62
PHE A  60
ALA A 129
ALA A 130
 None
 0.80A 3ax9B-1inlA:
undetectable		 3ax9B-1inlA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k44 NUCLEOSIDE
DIPHOSPHATE KINASE

(Mycobacterium
tuberculosis) 		PF00334
(NDK) 		4 SER A 119
THR A   5
ALA A  73
ALA A  74
 None
 1.03A 3ax9B-1k44A:
undetectable		 3ax9B-1k44A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		4 LEU A 268
SER A 265
THR A 217
ALA A 239
 None
 0.98A 3ax9B-1kyhA:
undetectable		 3ax9B-1kyhA:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		8 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
ALA A1078
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
MOS  A3004 (-3.0A)
TEI  A3006 ( 3.8A)
 0.25A 3ax9B-1n5xA:
44.0		 3ax9B-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzy 4-CHLOROBENZOYL
COENZYME A
DEHALOGENASE

(Pseudomonas sp.
CBS3) 		PF00378
(ECH_1) 		4 ARG B 192
PHE B 191
THR B  54
ALA B 131
 PO4  B 902 (-4.2A)
None
None
None
 0.64A 3ax9B-1nzyB:
undetectable		 3ax9B-1nzyB:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 PHE A 106
THR A 137
ALA A 377
ALA A 105
 None
KPA  A 500 (-2.9A)
None
None
 0.84A 3ax9B-1vb3A:
undetectable		 3ax9B-1vb3A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		4 LEU A 219
PHE A 315
ALA A 311
ALA A 312
 None
 0.79A 3ax9B-1xszA:
undetectable		 3ax9B-1xszA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU I 298
SER I 300
THR I 303
ALA I 291
 None
 1.02A 3ax9B-1yveI:
undetectable		 3ax9B-1yveI:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		4 LEU A  97
SER A 100
ALA A 145
ALA A  71
 None
 1.02A 3ax9B-2a0uA:
undetectable		 3ax9B-2a0uA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9
SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana) 		PF00071
(Ras)
PF02204
(VPS9) 		4 SER B  49
PHE B  47
ALA A 224
ALA A 223
 None
 0.90A 3ax9B-2efeB:
undetectable		 3ax9B-2efeB:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		4 SER A 212
THR A 161
ALA A  77
ALA A 107
 None
 0.98A 3ax9B-2hp3A:
undetectable		 3ax9B-2hp3A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3e G-RICH

(Carassius
auratus) 		PF05881
(CNPase) 		4 LEU A 175
THR A 195
ALA A 104
ALA A 205
 None
 0.92A 3ax9B-2i3eA:
undetectable		 3ax9B-2i3eA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A  88
THR A  54
ALA A  64
ALA A  63
 None
 0.85A 3ax9B-2ihtA:
undetectable		 3ax9B-2ihtA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		4 SER A  64
ARG A 354
PHE A 351
ALA A 347
 FAD  A1466 (-4.4A)
None
None
None
 1.00A 3ax9B-2ivdA:
undetectable		 3ax9B-2ivdA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 LEU A 324
THR A  98
ALA A 282
ALA A 283
 None
 1.02A 3ax9B-2livA:
undetectable		 3ax9B-2livA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 328
SER A 331
PHE A 153
ALA A 155
 None
 0.67A 3ax9B-2nqlA:
undetectable		 3ax9B-2nqlA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		4 SER A  36
ARG A  32
ALA A 243
ALA A 244
 None
 1.01A 3ax9B-2ogaA:
undetectable		 3ax9B-2ogaA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 GLU A 329
SER A 365
PHE A 392
ALA A 395
 None
 1.01A 3ax9B-2q3zA:
undetectable		 3ax9B-2q3zA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 LEU A  51
SER A  48
THR A  61
ALA A  14
 None
 0.99A 3ax9B-2qhxA:
undetectable		 3ax9B-2qhxA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLU A 156
ARG A 148
ALA A 132
ALA A 133
 GLU  A 156 ( 0.6A)
ARG  A 148 ( 0.6A)
ALA  A 132 ( 0.0A)
ALA  A 133 ( 0.0A)
 1.03A 3ax9B-2vbfA:
undetectable		 3ax9B-2vbfA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vob TRYPANOTHIONE
SYNTHETASE

(Leishmania
major) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 LEU A 220
SER A 268
ALA A 627
ALA A 628
 None
 1.02A 3ax9B-2vobA:
undetectable		 3ax9B-2vobA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 LEU B 303
ARG B 310
PHE B 344
THR B 460
ALA B 528
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.29A 3ax9B-2w55B:
56.5		 3ax9B-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		4 LEU A 813
PHE A 766
THR A 786
ALA A 848
 None
 0.89A 3ax9B-2x6kA:
3.4		 3ax9B-2x6kA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 SER A 310
THR A 401
ALA A 431
ALA A 419
 AIX  A 501 (-2.8A)
AIX  A 501 ( 4.0A)
None
None
 1.00A 3ax9B-3a3iA:
1.8		 3ax9B-3a3iA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3att PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01636
(APH) 		4 GLU A 277
THR A 198
ALA A 238
ALA A 239
 None
 1.00A 3ax9B-3attA:
undetectable		 3ax9B-3attA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		4 PHE X  39
THR X 227
ALA X  35
ALA X  36
 None
 0.92A 3ax9B-3dwoX:
undetectable		 3ax9B-3dwoX:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU A 298
SER A 300
THR A 303
ALA A 291
 None
 1.01A 3ax9B-3fr8A:
undetectable		 3ax9B-3fr8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		4 SER A 207
THR A 155
ALA A 133
ALA A 134
 None
 0.95A 3ax9B-3hxkA:
undetectable		 3ax9B-3hxkA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieg DNAJ HOMOLOG
SUBFAMILY C MEMBER 3

(Mus musculus) 		PF09976
(TPR_21)
PF13181
(TPR_8) 		4 LEU A  57
THR A  79
ALA A  89
ALA A  90
 None
 0.92A 3ax9B-3iegA:
undetectable		 3ax9B-3iegA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		4 LEU A 233
SER A 236
ALA A 160
ALA A 159
 None
 0.88A 3ax9B-3iehA:
undetectable		 3ax9B-3iehA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 280
LEU A 267
ARG A 342
ALA A 420
 None
 0.99A 3ax9B-3ihvA:
undetectable		 3ax9B-3ihvA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 472
SER A 350
PHE A 260
ALA A 424
 None
 0.90A 3ax9B-3jq0A:
undetectable		 3ax9B-3jq0A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
sp. ADP1) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 LEU A 193
SER A 241
ALA A 236
ALA A 235
 None
 1.03A 3ax9B-3k1nA:
undetectable		 3ax9B-3k1nA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		4 GLU A  83
THR A 209
ALA A 299
ALA A 298
 None
 0.82A 3ax9B-3mc2A:
undetectable		 3ax9B-3mc2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkh NITROALKANE OXIDASE

(Podospora
anserina) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A  21
THR A  50
ALA A  93
ALA A  92
 None
 1.01A 3ax9B-3mkhA:
undetectable		 3ax9B-3mkhA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		4 SER A 201
THR A  46
ALA A  18
ALA A  19
 None
 0.65A 3ax9B-3oc6A:
undetectable		 3ax9B-3oc6A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdx TYROSINE
AMINOTRANSFERASE

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 LEU A 278
THR A 334
ALA A 326
ALA A  96
 None
 0.84A 3ax9B-3pdxA:
undetectable		 3ax9B-3pdxA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 LEU A 189
PHE A  54
ALA A  75
ALA A  74
 None
 0.96A 3ax9B-3pkoA:
undetectable		 3ax9B-3pkoA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 LEU A 119
THR A  55
ALA A 125
ALA A 102
 None
 0.99A 3ax9B-3q0gA:
undetectable		 3ax9B-3q0gA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbg PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF12134
(PRP8_domainIV) 		4 LEU A1882
PHE A1965
THR A2009
ALA A1968
 None
 1.02A 3ax9B-3sbgA:
undetectable		 3ax9B-3sbgA:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		8 GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
ALA C1078
ALA C1079
 RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
 0.24A 3ax9B-3sr6C:
66.1		 3ax9B-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7c CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 LEU A 177
THR A 135
ALA A 105
ALA A 104
 None
None
NAD  A 279 (-3.3A)
NAD  A 279 (-3.6A)
 0.90A 3ax9B-3t7cA:
undetectable		 3ax9B-3t7cA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacteroides
abscessus) 		PF01182
(Glucosamine_iso) 		4 SER A 203
THR A  46
ALA A  18
ALA A  19
 None
 0.74A 3ax9B-3tx2A:
undetectable		 3ax9B-3tx2A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 PHE A 125
THR A 158
ALA A 430
ALA A 124
 None
MLA  A 484 ( 3.4A)
None
None
 1.01A 3ax9B-3v7nA:
undetectable		 3ax9B-3v7nA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhy 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Mycobacterium
tuberculosis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 131
SER A 130
ALA A 142
ALA A 141
 None
 0.88A 3ax9B-3zhyA:
undetectable		 3ax9B-3zhyA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		4 LEU A  58
ARG A 190
ALA A 206
ALA A 205
 None
 1.03A 3ax9B-3zouA:
undetectable		 3ax9B-3zouA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 LEU A 604
THR A 608
ALA A 588
ALA A 585
 None
 1.03A 3ax9B-4aioA:
undetectable		 3ax9B-4aioA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ate BETA-PORPHYRANASE A

(Zobellia
galactanivorans) 		no annotation 4 LEU A 254
THR A 261
ALA A 100
ALA A 101
 None
 0.96A 3ax9B-4ateA:
undetectable		 3ax9B-4ateA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 LEU A 157
PHE A 259
ALA A 275
ALA A 258
 None
 0.91A 3ax9B-4b52A:
undetectable		 3ax9B-4b52A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7r PROLINE/BETAINE
TRANSPORTER, RALF

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		4 LEU A 217
PHE A 313
ALA A 309
ALA A 310
 None
 0.79A 3ax9B-4d7rA:
undetectable		 3ax9B-4d7rA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkb DEOXYURIDINE
TRIPHOSPHATASE

(Trypanosoma
brucei) 		PF08761
(dUTPase_2) 		4 LEU A  52
THR A  78
ALA A 193
ALA A 194
 None
 1.02A 3ax9B-4dkbA:
undetectable		 3ax9B-4dkbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 251
THR A 282
ALA A 258
ALA A 257
 None
 0.79A 3ax9B-4dx3A:
undetectable		 3ax9B-4dx3A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ell RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 LEU A 486
PHE A 482
ALA A 602
ALA A 603
 None
 0.77A 3ax9B-4ellA:
undetectable		 3ax9B-4ellA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA

(Rhodococcus
rhodochrous) 		PF00067
(p450) 		4 LEU A 344
SER A 345
ALA A 321
ALA A 337
 None
 1.03A 3ax9B-4ep6A:
1.8		 3ax9B-4ep6A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fas HYDROXYLAMINE
OXIDOREDUCTASE

(Nitrosomonas
europaea) 		PF13447
(Multi-haem_cyto) 		4 GLU A 293
LEU A 114
ALA A 251
ALA A 250
 None
None
None
HEC  A 603 (-3.4A)
 0.93A 3ax9B-4fasA:
undetectable		 3ax9B-4fasA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 LEU B 916
SER B 919
ALA B 954
ALA B 957
 None
 1.03A 3ax9B-4fhnB:
undetectable		 3ax9B-4fhnB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		4 LEU B 920
SER B 919
ALA B 953
ALA B 954
 None
 1.02A 3ax9B-4fhnB:
undetectable		 3ax9B-4fhnB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 4 LEU A 380
SER A 383
ALA A 239
ALA A 240
 None
 0.86A 3ax9B-4iegA:
undetectable		 3ax9B-4iegA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		4 GLU A 422
LEU A 441
ALA A 429
ALA A 430
 None
 0.98A 3ax9B-4l22A:
undetectable		 3ax9B-4l22A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 463
SER A 343
PHE A 253
ALA A 417
 None
 0.87A 3ax9B-4l7tA:
undetectable		 3ax9B-4l7tA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvu OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Burkholderia
thailandensis) 		PF13561
(adh_short_C2) 		4 LEU A  27
SER A  26
ALA A 109
ALA A 108
 None
 0.90A 3ax9B-4lvuA:
undetectable		 3ax9B-4lvuA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN

(Sulfolobus
solfataricus) 		PF05138
(PaaA_PaaC) 		4 LEU A 153
SER A 149
THR A 109
ALA A 165
 None
 0.84A 3ax9B-4mudA:
undetectable		 3ax9B-4mudA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A 124
SER A 123
ALA A 187
ALA A 184
 None
 0.91A 3ax9B-4mz0A:
undetectable		 3ax9B-4mz0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 LEU B  22
SER B  25
PHE B 175
THR B 143
 None
 0.68A 3ax9B-4nfuB:
undetectable		 3ax9B-4nfuB:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmw DIS3-LIKE
EXONUCLEASE 2

(Mus musculus) 		PF00773
(RNB)
PF17216
(Rrp44_CSD1) 		4 LEU A 713
PHE A 697
ALA A 590
ALA A 587
 None
 0.95A 3ax9B-4pmwA:
2.8		 3ax9B-4pmwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 746
ARG A 743
ALA A 700
ALA A 701
 None
 0.83A 3ax9B-4rcnA:
3.9		 3ax9B-4rcnA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u13 PUTATIVE POLYKETIDE
CYCLASE SMA1630

(Sinorhizobium
meliloti) 		PF12680
(SnoaL_2) 		4 LEU A   3
SER A   0
PHE A  -2
ALA A  76
 None
 0.96A 3ax9B-4u13A:
undetectable		 3ax9B-4u13A:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0n BARDET-BIEDL
SYNDROME 1 PROTEIN

(Chlamydomonas
reinhardtii) 		PF14779
(BBS1) 		4 LEU B 418
PHE B 394
THR B 354
ALA B 361
 None
 0.85A 3ax9B-4v0nB:
undetectable		 3ax9B-4v0nB:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF00155
(Aminotran_1_2) 		4 LEU A 326
ARG A  32
ALA A  36
ALA A  35
 None
 0.96A 3ax9B-4wbtA:
undetectable		 3ax9B-4wbtA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxw UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		4 LEU A 361
PHE A 405
THR A 329
ALA A 387
 None
 1.00A 3ax9B-4wxwA:
undetectable		 3ax9B-4wxwA:
9.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		8 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
ALA A1078
ALA A1079
 URC  A3007 (-3.0A)
None
None
URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
URC  A3007 (-3.5A)
URC  A3007 (-3.4A)
 0.32A 3ax9B-4yswA:
44.0		 3ax9B-4yswA:
86.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 LEU A 367
SER A 364
THR A  94
ALA A 117
 None
 1.03A 3ax9B-4zm6A:
undetectable		 3ax9B-4zm6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn6 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Acinetobacter
baumannii) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 137
SER A 140
ALA A 148
ALA A 147
 None
 0.91A 3ax9B-4zn6A:
undetectable		 3ax9B-4zn6A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		4 LEU A 120
SER A 124
ALA A 137
ALA A 138
 None
 1.03A 3ax9B-5cykA:
undetectable		 3ax9B-5cykA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 LEU A 270
SER A 271
ALA A 233
ALA A 232
 LEU  A 270 ( 0.5A)
SER  A 271 ( 0.0A)
ALA  A 233 ( 0.0A)
ALA  A 232 (-0.0A)
 0.82A 3ax9B-5d7wA:
undetectable		 3ax9B-5d7wA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk6 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Colwellia
psychrerythraea) 		PF01048
(PNP_UDP_1) 		4 LEU A 240
SER A 241
ALA A 128
ALA A 127
 None
 1.00A 3ax9B-5dk6A:
undetectable		 3ax9B-5dk6A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae) 		PF02265
(S1-P1_nuclease) 		4 GLU A 265
LEU A 195
ALA A 179
ALA A 180
 None
 1.01A 3ax9B-5fbbA:
undetectable		 3ax9B-5fbbA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 LEU B 688
PHE B 657
ALA B 661
ALA B 660
 None
 1.00A 3ax9B-5gztB:
undetectable		 3ax9B-5gztB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 LEU A 688
PHE A 657
ALA A 661
ALA A 660
 None
 1.01A 3ax9B-5gzuA:
undetectable		 3ax9B-5gzuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5has SEC7

(Thielavia
terrestris) 		PF12783
(Sec7_N)
PF16213
(DCB) 		4 LEU A  11
SER A  10
THR A  66
ALA A  55
 None
 0.82A 3ax9B-5hasA:
undetectable		 3ax9B-5hasA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc7 CEREBELLIN-1

(Homo sapiens) 		PF00386
(C1q) 		4 LEU A 133
ARG A 166
THR A 103
ALA A 106
 None
 0.97A 3ax9B-5kc7A:
undetectable		 3ax9B-5kc7A:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 LEU A 109
THR A 171
ALA A 116
ALA A 115
 None
 0.84A 3ax9B-5muxA:
undetectable		 3ax9B-5muxA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		4 LEU F 332
SER F 198
ALA F 112
ALA F 113
 None
 0.93A 3ax9B-5odrF:
undetectable		 3ax9B-5odrF:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5omt NUCB

(Bacillus
licheniformis) 		no annotation 4 GLU A  94
LEU A  81
ALA A  98
ALA A  73
 None
 0.74A 3ax9B-5omtA:
undetectable		 3ax9B-5omtA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN

(Norwalk virus) 		no annotation 4 GLU A 488
LEU A 474
PHE A 525
ALA A 528
 None
 1.01A 3ax9B-5or7A:
undetectable		 3ax9B-5or7A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A  36
ARG A 147
ALA A 149
ALA A 148
 None
 1.03A 3ax9B-5uj1A:
undetectable		 3ax9B-5uj1A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 LEU A 397
THR A 372
ALA A 405
ALA A 403
 None
 1.01A 3ax9B-5v0tA:
undetectable		 3ax9B-5v0tA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vye L-THREONINE ALDOLASE

(Pseudomonas
putida) 		no annotation 4 LEU A 217
PHE A 219
THR A  54
ALA A 190
 None
 1.03A 3ax9B-5vyeA:
undetectable		 3ax9B-5vyeA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 4 LEU B 214
ARG B 191
ALA B 168
ALA B 167
 None
 0.84A 3ax9B-6ckcB:
undetectable		 3ax9B-6ckcB:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 4 GLU A1165
LEU A 666
THR A 678
ALA A 608
 None
 0.87A 3ax9B-6co7A:
undetectable		 3ax9B-6co7A:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cyz HOMOSERINE KINASE

(Mycobacteroides
abscessus) 		no annotation 4 LEU A 279
THR A 276
ALA A 262
ALA A 261
 None
 1.01A 3ax9B-6cyzA:
2.6		 3ax9B-6cyzA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g96 ACETYLTRANSFERASE

(Salmonella
enterica) 		no annotation 4 LEU B 160
SER B 161
ALA B 168
ALA B 167
 None
 0.90A 3ax9B-6g96B:
undetectable		 3ax9B-6g96B:
4.93