SIMILAR PATTERNS OF AMINO ACIDS FOR 3AX9_A_SALA1341

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a59 CITRATE SYNTHASE

(Antarctic
bacterium
DS2-3R) 		PF00285
(Citrate_synt) 		4 LEU A 104
THR A 210
VAL A 209
ALA A  97
 None
 0.83A 3ax9A-1a59A:
0.0		 3ax9A-1a59A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bby RAP30

(Homo sapiens) 		PF02270
(TFIIF_beta) 		4 LEU A 217
THR A 206
VAL A 203
ALA A 190
 None
 0.95A 3ax9A-1bbyA:
2.0		 3ax9A-1bbyA:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cii COLICIN IA

(Escherichia
coli) 		PF01024
(Colicin)
PF11504
(Colicin_Ia) 		4 LEU A 596
SER A 594
VAL A 523
ALA A 518
 None
 1.00A 3ax9A-1ciiA:
3.7		 3ax9A-1ciiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans) 		PF00463
(ICL) 		4 SER A 101
THR A 122
VAL A 123
ALA A 116
 None
 0.97A 3ax9A-1dquA:
0.0		 3ax9A-1dquA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 292
SER A 295
PHE A 196
ALA A 199
 None
 1.00A 3ax9A-1e1tA:
0.0		 3ax9A-1e1tA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		4 LEU A 248
THR A 254
VAL A 255
ALA A  38
 None
 1.02A 3ax9A-1ekqA:
0.0		 3ax9A-1ekqA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 SER A 472
ARG A 476
VAL A 511
ALA A 502
 None
 0.81A 3ax9A-1gpeA:
1.5		 3ax9A-1gpeA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 LEU A 255
SER A 212
VAL A 164
ALA A 168
 None
 0.98A 3ax9A-1hkwA:
0.0		 3ax9A-1hkwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 LEU A 317
THR A 337
VAL A 338
ALA A 329
 None
 0.90A 3ax9A-1idmA:
2.9		 3ax9A-1idmA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Galdieria
partita) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 291
THR A 243
VAL A 242
ALA A 276
 None
 0.89A 3ax9A-1iwaA:
undetectable		 3ax9A-1iwaA:
17.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		8 GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-4.8A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
TEI  A3006 ( 3.8A)
 0.36A 3ax9A-1n5xA:
44.2		 3ax9A-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 SER A 876
PHE A 914
VAL A1011
ALA A1078
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
MOS  A3004 (-3.0A)
 0.99A 3ax9A-1n5xA:
44.2		 3ax9A-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 LEU A 319
PHE A 313
VAL A 307
ALA A 310
 None
None
None
FMN  A 702 (-3.5A)
 0.99A 3ax9A-1ps9A:
undetectable		 3ax9A-1ps9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 SER A  47
THR A  50
VAL A  51
ALA A  35
 None
 0.95A 3ax9A-1q5nA:
undetectable		 3ax9A-1q5nA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		4 LEU A 113
ARG A 107
VAL A 116
ALA A 103
 None
 1.00A 3ax9A-1qjcA:
undetectable		 3ax9A-1qjcA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 291
THR A 243
VAL A 242
ALA A 276
 None
 0.95A 3ax9A-1rblA:
undetectable		 3ax9A-1rblA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 284
THR A 236
VAL A 235
ALA A 269
 None
 0.96A 3ax9A-1svdA:
undetectable		 3ax9A-1svdA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 LEU A 102
SER A 104
THR A  81
ALA A 120
 None
 1.02A 3ax9A-1txgA:
undetectable		 3ax9A-1txgA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		4 LEU A 216
PHE A 227
THR A   3
VAL A  82
 None
None
None
CA  A 503 (-4.9A)
 0.94A 3ax9A-1v6cA:
undetectable		 3ax9A-1v6cA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ARG A 209
THR A 138
VAL A 124
ALA A 205
 None
 1.00A 3ax9A-1v9pA:
undetectable		 3ax9A-1v9pA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		4 LEU A 217
PHE A 157
THR A 210
ALA A 113
 None
 0.98A 3ax9A-1vhkA:
undetectable		 3ax9A-1vhkA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU I 298
SER I 300
THR I 303
ALA I 291
 None
 0.99A 3ax9A-1yveI:
undetectable		 3ax9A-1yveI:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 LEU A 104
THR A  94
VAL A  91
ALA A  48
 None
 0.85A 3ax9A-1yxmA:
undetectable		 3ax9A-1yxmA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 158
ARG A 212
THR A 258
VAL A 259
 None
 1.00A 3ax9A-1zpuA:
undetectable		 3ax9A-1zpuA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b24 NAPHTHALENE
DIOXYGENASE SMALL
SUBUNIT

(Rhodococcus sp.
NCIMB 12038) 		PF00866
(Ring_hydroxyl_B) 		4 LEU B 649
THR B 546
VAL B 545
ALA B 652
 None
 0.98A 3ax9A-2b24B:
undetectable		 3ax9A-2b24B:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU A 850
PHE A 828
VAL A 911
ALA A 914
 None
 0.96A 3ax9A-2b39A:
undetectable		 3ax9A-2b39A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 LEU A1045
SER A1044
THR A1020
ALA A1088
 None
 0.97A 3ax9A-2b39A:
undetectable		 3ax9A-2b39A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkn 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE

(Pseudomonas sp.
B-0831) 		PF13561
(adh_short_C2) 		4 LEU A 190
SER A 194
THR A 204
ALA A 185
 NAI  A4000 (-3.7A)
None
None
NAI  A4000 (-4.4A)
 1.00A 3ax9A-2dknA:
undetectable		 3ax9A-2dknA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 GLU A 177
SER A 205
ARG A 217
VAL A 214
 None
 1.01A 3ax9A-2eidA:
undetectable		 3ax9A-2eidA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Aquifex
aeolicus) 		PF00290
(Trp_syntA) 		4 LEU A  23
SER A  21
VAL A 253
ALA A 236
 None
 0.84A 3ax9A-2ekcA:
undetectable		 3ax9A-2ekcA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		4 LEU A 222
SER A 225
PHE A   6
ALA A  33
 None
 0.96A 3ax9A-2et6A:
undetectable		 3ax9A-2et6A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		4 SER A  52
PHE A  49
VAL A  54
ALA A 214
 None
 1.01A 3ax9A-2fbvA:
undetectable		 3ax9A-2fbvA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flh CYTOKININ-SPECIFIC
BINDING PROTEIN

(Vigna radiata) 		PF00407
(Bet_v_1) 		4 LEU A 146
ARG A 144
THR A   9
VAL A 114
 None
 0.97A 3ax9A-2flhA:
undetectable		 3ax9A-2flhA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh9 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		5 LEU A 296
ARG A 305
PHE A 111
THR A  61
VAL A 271
 None
MLR  A2913 (-3.0A)
None
None
None
 1.33A 3ax9A-2gh9A:
undetectable		 3ax9A-2gh9A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq0 CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90) 		4 LEU A 382
THR A 353
VAL A 356
ALA A 395
 None
 0.97A 3ax9A-2gq0A:
undetectable		 3ax9A-2gq0A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzm GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		4 GLU A  30
LEU A 220
VAL A  71
ALA A   6
 None
 1.01A 3ax9A-2gzmA:
1.0		 3ax9A-2gzmA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 865
PHE A 888
VAL A 878
ALA A 887
 None
 0.99A 3ax9A-2hnhA:
undetectable		 3ax9A-2hnhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrb CARBONYL REDUCTASE
[NADPH] 3

(Homo sapiens) 		PF00106
(adh_short) 		4 LEU A 208
SER A 205
ARG A 206
VAL A 201
 None
None
GOL  A2002 (-3.6A)
None
 1.00A 3ax9A-2hrbA:
undetectable		 3ax9A-2hrbA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A  36
SER A 148
VAL A 105
ALA A 141
 None
 0.92A 3ax9A-2hsmA:
undetectable		 3ax9A-2hsmA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 LEU A 409
PHE A 405
THR A 177
ALA A 191
 None
 1.00A 3ax9A-2i7tA:
undetectable		 3ax9A-2i7tA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5u MREC PROTEIN

(Listeria
monocytogenes) 		PF04085
(MreC) 		4 LEU A 173
THR A 152
VAL A 270
ALA A 262
 None
 1.01A 3ax9A-2j5uA:
undetectable		 3ax9A-2j5uA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jah CLAVULANIC ACID
DEHYDROGENASE

(Streptomyces
clavuligerus) 		PF00106
(adh_short) 		4 LEU A  88
THR A  78
VAL A  75
ALA A  37
 None
 0.93A 3ax9A-2jahA:
undetectable		 3ax9A-2jahA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		4 LEU A 693
SER A 689
THR A 684
VAL A 685
 None
 0.90A 3ax9A-2pggA:
undetectable		 3ax9A-2pggA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		4 SER A  31
PHE A  88
VAL A  81
ALA A  87
 None
 0.94A 3ax9A-2ps3A:
0.9		 3ax9A-2ps3A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhx PTERIDINE REDUCTASE
1

(Leishmania
major) 		PF00106
(adh_short)
PF13561
(adh_short_C2) 		4 LEU A  51
SER A  48
THR A  61
ALA A  14
 None
 1.00A 3ax9A-2qhxA:
undetectable		 3ax9A-2qhxA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uun C-PHYCOCYANIN

(Leptolyngbya
sp.) 		PF00502
(Phycobilisome) 		4 LEU A  51
THR A  96
VAL A  95
ALA A  40
 None
 1.00A 3ax9A-2uunA:
undetectable		 3ax9A-2uunA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjt ALLOPHYCOCYANIN BETA
SUBUNIT

(Gloeobacter
violaceus) 		PF00502
(Phycobilisome) 		4 LEU B  89
PHE B 153
VAL B 136
ALA B 149
 None
 1.00A 3ax9A-2vjtB:
undetectable		 3ax9A-2vjtB:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvt GLUTAMATE RACEMASE

(Enterococcus
faecalis) 		PF01177
(Asp_Glu_race) 		4 GLU A  30
LEU A 220
VAL A  71
ALA A   6
 None
 1.01A 3ax9A-2vvtA:
undetectable		 3ax9A-2vvtA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU B 303
ARG B 310
PHE B 344
THR B 460
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
HPA  B1780 ( 3.2A)
 0.40A 3ax9A-2w55B:
52.8		 3ax9A-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk1 NOVP

(Actinoalloteichus
cyanogriseus) 		PF05711
(TylF) 		4 LEU A  71
ARG A  52
THR A  29
ALA A  62
 None
 0.97A 3ax9A-2wk1A:
undetectable		 3ax9A-2wk1A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A 441
SER A 440
VAL A 170
ALA A 166
 None
None
None
FAD  A 601 (-3.2A)
 1.01A 3ax9A-2wu5A:
undetectable		 3ax9A-2wu5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		4 LEU A 297
PHE A 295
VAL A 461
ALA A  50
 None
 0.98A 3ax9A-2x98A:
undetectable		 3ax9A-2x98A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 GLU A 458
SER A 614
THR A 571
ALA A 431
 None
 0.96A 3ax9A-2xaxA:
undetectable		 3ax9A-2xaxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 272
SER A 279
PHE A 193
THR A 241
 None
 0.99A 3ax9A-2xd4A:
2.2		 3ax9A-2xd4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylf PROTEIN SPIRE
HOMOLOG 1

(Homo sapiens) 		PF16474
(KIND) 		4 LEU A  69
SER A  68
VAL A  96
ALA A  99
 None
 0.96A 3ax9A-2ylfA:
undetectable		 3ax9A-2ylfA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 178
ARG A 267
VAL A 338
ALA A 333
 None
 0.96A 3ax9A-2z01A:
undetectable		 3ax9A-2z01A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT

(Aquifex
aeolicus) 		PF02222
(ATP-grasp) 		4 LEU A 224
PHE A 234
VAL A  89
ALA A 252
 None
 0.88A 3ax9A-2z04A:
3.8		 3ax9A-2z04A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		4 SER A 180
THR A 388
VAL A 389
ALA A 281
 None
 0.87A 3ax9A-3a2qA:
undetectable		 3ax9A-3a2qA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A 377
PHE A 292
THR A 353
VAL A 380
 None
 1.00A 3ax9A-3a5rA:
undetectable		 3ax9A-3a5rA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		4 LEU A 193
THR A 150
VAL A 153
ALA A 226
 None
 0.90A 3ax9A-3a6pA:
undetectable		 3ax9A-3a6pA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aty PROSTAGLANDIN F2A
SYNTHASE

(Trypanosoma
cruzi) 		PF00724
(Oxidored_FMN) 		4 LEU A 271
ARG A 207
PHE A 206
ALA A 197
 None
 0.87A 3ax9A-3atyA:
undetectable		 3ax9A-3atyA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ceu THIAMINE PHOSPHATE
PYROPHOSPHORYLASE

(Bacteroides
thetaiotaomicron) 		PF02581
(TMP-TENI) 		5 GLU A  15
LEU A  45
SER A  42
PHE A  11
THR A  37
 None
 1.44A 3ax9A-3ceuA:
undetectable		 3ax9A-3ceuA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cit SENSOR HISTIDINE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 4 GLU A  67
LEU A 159
VAL A  50
ALA A  78
 None
 0.93A 3ax9A-3citA:
undetectable		 3ax9A-3citA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
fragilis) 		PF13419
(HAD_2) 		4 LEU A  50
SER A  53
PHE A  25
THR A  45
 None
 0.94A 3ax9A-3d6jA:
undetectable		 3ax9A-3d6jA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 227
PHE A 310
VAL A 240
ALA A 308
 None
 0.92A 3ax9A-3dkhA:
undetectable		 3ax9A-3dkhA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drx BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD5

(Homo sapiens) 		PF02214
(BTB_2) 		4 LEU A  70
ARG A 107
THR A  57
VAL A  46
 None
 1.02A 3ax9A-3drxA:
undetectable		 3ax9A-3drxA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etn PUTATIVE
PHOSPHOSUGAR
ISOMERASE INVOLVED
IN CAPSULE FORMATION

(Bacteroides
fragilis) 		PF01380
(SIS) 		4 LEU A  43
THR A 171
VAL A 168
ALA A  28
 None
 0.96A 3ax9A-3etnA:
undetectable		 3ax9A-3etnA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 LEU A 298
SER A 300
THR A 303
ALA A 291
 None
 0.98A 3ax9A-3fr8A:
undetectable		 3ax9A-3fr8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxa SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 SER A 165
THR A  28
VAL A 142
ALA A  32
 None
 0.73A 3ax9A-3fxaA:
undetectable		 3ax9A-3fxaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ge9 THYMIDYLATE SYNTHASE
THYX

(Corynebacterium
glutamicum) 		PF02511
(Thy1) 		4 LEU A 235
SER A 239
VAL A 206
ALA A 200
 None
 1.01A 3ax9A-3ge9A:
2.6		 3ax9A-3ge9A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtd FUMARATE HYDRATASE
CLASS II

(Rickettsia
prowazekii) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LEU A 225
THR A 152
VAL A 153
ALA A  47
 None
 0.89A 3ax9A-3gtdA:
undetectable		 3ax9A-3gtdA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE

(Rauvolfia
serpentina) 		PF00561
(Abhydrolase_1) 		4 LEU A  93
PHE A 109
VAL A 206
ALA A 209
 None
 0.95A 3ax9A-3gzjA:
undetectable		 3ax9A-3gzjA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiq VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		4 LEU A 144
SER A 147
THR A 149
ALA A  58
 None
 0.95A 3ax9A-3hiqA:
undetectable		 3ax9A-3hiqA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiq VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		4 LEU A 144
THR A 149
VAL A 151
ALA A  58
 None
 0.80A 3ax9A-3hiqA:
undetectable		 3ax9A-3hiqA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A 144
SER A 147
THR A 149
VAL A 151
ALA A  58
 None
 1.03A 3ax9A-3hiwA:
undetectable		 3ax9A-3hiwA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU A 245
SER A 246
VAL A 205
ALA A 252
 None
 0.97A 3ax9A-3hrdA:
15.1		 3ax9A-3hrdA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		4 LEU A 209
PHE A 409
VAL A 252
ALA A 257
 None
 0.98A 3ax9A-3i3vA:
undetectable		 3ax9A-3i3vA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A  67
THR A  21
VAL A  20
ALA A 461
 None
 0.94A 3ax9A-3i8bA:
undetectable		 3ax9A-3i8bA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iau THREONINE DEAMINASE

(Solanum
lycopersicum) 		PF00291
(PALP) 		4 LEU A 253
SER A 252
VAL A 276
ALA A 282
 None
 1.00A 3ax9A-3iauA:
undetectable		 3ax9A-3iauA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
furiosus) 		PF07969
(Amidohydro_3) 		4 SER A  98
THR A 476
VAL A 475
ALA A 344
 None
None
None
KCX  A 294 ( 4.1A)
 0.91A 3ax9A-3icjA:
undetectable		 3ax9A-3icjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ist GLUTAMATE RACEMASE

(Listeria
monocytogenes) 		PF01177
(Asp_Glu_race) 		4 GLU A  28
LEU A 218
VAL A  69
ALA A   4
 None
 0.99A 3ax9A-3istA:
undetectable		 3ax9A-3istA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwr CHITINASE

(Oryza sativa) 		PF00182
(Glyco_hydro_19) 		4 LEU A 102
ARG A 100
VAL A  93
ALA A 312
 None
 0.88A 3ax9A-3iwrA:
undetectable		 3ax9A-3iwrA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 LEU W 774
SER W 866
THR W 408
ALA W 414
 None
 0.93A 3ax9A-3iylW:
undetectable		 3ax9A-3iylW:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0c E1 ENVELOPE
GLYCOPROTEIN

(Venezuelan
equine
encephalitis
virus) 		PF01589
(Alpha_E1_glycop) 		4 LEU A  27
PHE A 287
VAL A 159
ALA A 285
 None
 0.91A 3ax9A-3j0cA:
undetectable		 3ax9A-3j0cA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 472
SER A 350
PHE A 260
ALA A 424
 None
 0.90A 3ax9A-3jq0A:
undetectable		 3ax9A-3jq0A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 448
SER A 336
PHE A 251
ALA A 423
 None
 1.01A 3ax9A-3jq1A:
undetectable		 3ax9A-3jq1A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldf PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.776

(Streptococcus
mutans) 		PF10672
(Methyltrans_SAM) 		4 GLU A 178
LEU A 197
VAL A 185
ALA A 225
 None
None
None
SAH  A 401 ( 4.8A)
 1.00A 3ax9A-3ldfA:
2.5		 3ax9A-3ldfA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lim FRAGACEATOXIN C

(Actinia
fragacea) 		PF06369
(Anemone_cytotox) 		4 GLU A 173
LEU A  14
THR A  21
VAL A  22
 None
 0.90A 3ax9A-3limA:
undetectable		 3ax9A-3limA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ny7 SULFATE TRANSPORTER

(Escherichia
coli) 		PF01740
(STAS) 		4 LEU A 467
ARG A 438
VAL A 488
ALA A 440
 None
 0.90A 3ax9A-3ny7A:
undetectable		 3ax9A-3ny7A:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 LEU B 336
SER B 345
THR B 385
ALA B 342
 None
 0.95A 3ax9A-3ohmB:
undetectable		 3ax9A-3ohmB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 LEU A 322
SER A 444
ARG A 459
VAL A 446
 None
 0.93A 3ax9A-3okyA:
undetectable		 3ax9A-3okyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		4 LEU A 199
SER A 209
VAL A 249
ALA A 298
 None
 1.02A 3ax9A-3os6A:
undetectable		 3ax9A-3os6A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oxh RV0577 PROTEIN

(Mycobacterium
tuberculosis) 		PF00903
(Glyoxalase) 		4 LEU A 126
SER A 114
VAL A 100
ALA A 123
 None
 0.78A 3ax9A-3oxhA:
undetectable		 3ax9A-3oxhA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 228
PHE A 310
VAL A 241
ALA A 308
 None
 0.98A 3ax9A-3ppsA:
undetectable		 3ax9A-3ppsA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q33 HISTONE
ACETYLTRANSFERASE
RTT109

(Saccharomyces
cerevisiae) 		PF08214
(HAT_KAT11) 		4 LEU A  20
SER A  54
PHE A  56
ALA A 379
 None
 0.99A 3ax9A-3q33A:
undetectable		 3ax9A-3q33A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qld MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  79
ARG A  77
VAL A  72
ALA A  96
 None
 0.94A 3ax9A-3qldA:
undetectable		 3ax9A-3qldA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qta CHEMOTAXIS PROTEIN
CHEC

(Haloarcula
marismortui) 		PF13690
(CheX) 		4 LEU A 178
SER A 165
VAL A  38
ALA A 175
 None
 0.76A 3ax9A-3qtaA:
undetectable		 3ax9A-3qtaA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvq PHOSPHODIESTERASE
OLEI02445

(Oleispira
antarctica) 		PF03009
(GDPD) 		4 LEU A 135
SER A 131
VAL A  44
ALA A 102
 None
 0.99A 3ax9A-3qvqA:
undetectable		 3ax9A-3qvqA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 SER A  56
THR A  62
VAL A  61
ALA A  70
 None
 0.85A 3ax9A-3r5tA:
undetectable		 3ax9A-3r5tA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7g PROTEIN SPIRE
HOMOLOG 1

(Homo sapiens) 		PF16474
(KIND) 		4 LEU A  69
SER A  68
VAL A  96
ALA A  99
 None
 0.95A 3ax9A-3r7gA:
undetectable		 3ax9A-3r7gA:
9.76