SIMILAR PATTERNS OF AMINO ACIDS FOR 3AX7_B_SALB1336_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b04 PROTEIN (DNA LIGASE)

(Geobacillus
stearothermophilus) 		PF01653
(DNA_ligase_aden) 		5 ARG A 204
THR A 134
VAL A 120
ALA A 199
ALA A 200
 None
 1.28A 3ax7B-1b04A:
0.0		 3ax7B-1b04A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctt CYTIDINE DEAMINASE

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2) 		5 ARG A  78
THR A 123
VAL A 124
LEU A 149
ALA A 154
 None
 1.43A 3ax7B-1cttA:
0.0		 3ax7B-1cttA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1u HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Arthrobacter
globiformis) 		PF00903
(Glyoxalase) 		5 GLU A 267
ARG A 152
THR A 198
VAL A 199
ALA A 216
 MN  A 500 (-2.8A)
None
None
None
MN  A 500 ( 4.5A)
 1.40A 3ax7B-1f1uA:
0.0		 3ax7B-1f1uA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.43A 3ax7B-1kcxA:
0.0		 3ax7B-1kcxA:
17.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		9 GLU A 802
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1078
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
MOS  A3004 (-3.0A)
TEI  A3006 ( 3.8A)
 0.28A 3ax7B-1n5xA:
44.6		 3ax7B-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ARG A 297
THR A 269
VAL A 268
LEU A 223
ALA A 272
 None
 1.33A 3ax7B-1v26A:
0.0		 3ax7B-1v26A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 ARG A 209
THR A 138
VAL A 124
ALA A 204
ALA A 205
 None
 1.16A 3ax7B-1v9pA:
0.0		 3ax7B-1v9pA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsv AMINOMETHYLTRANSFERA
SE

(Homo sapiens) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 GLU A  71
SER A  89
THR A  87
VAL A 104
ALA A  79
 GLU  A  71 ( 0.6A)
SER  A  89 ( 0.0A)
THR  A  87 ( 0.8A)
VAL  A 104 ( 0.6A)
ALA  A  79 ( 0.0A)
 1.23A 3ax7B-1wsvA:
0.0		 3ax7B-1wsvA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		5 ARG A 513
THR A 399
VAL A 400
LEU A 364
ALA A 394
 None
 1.12A 3ax7B-1x0uA:
0.0		 3ax7B-1x0uA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 ARG A 384
VAL A 574
LEU A 530
ALA A 606
ALA A 607
 None
 1.40A 3ax7B-1xpgA:
2.3		 3ax7B-1xpgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 SER A 120
ARG A 117
VAL A 137
LEU A 151
ALA A 170
 None
 1.42A 3ax7B-1yr2A:
undetectable		 3ax7B-1yr2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvs MHC CLASS I ANTIGEN

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		5 GLU A 254
THR A 190
VAL A 189
LEU A 201
ALA A 199
 None
 1.45A 3ax7B-1zvsA:
undetectable		 3ax7B-1zvsA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT,
MITOCHONDRIAL

(Homo sapiens) 		PF02817
(E3_binding)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLU A 443
VAL K 167
LEU K 164
ALA K 134
ALA K 135
 None
 1.23A 3ax7B-1zy8A:
undetectable		 3ax7B-1zy8A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		5 PHE A 302
VAL A 284
LEU A 285
ALA A 326
ALA A 327
 None
 1.37A 3ax7B-2i6bA:
0.7		 3ax7B-2i6bA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwg 52 KDA RO PROTEIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 ARG B 160
THR B  12
VAL B  48
LEU B   8
ALA B  51
 None
 1.45A 3ax7B-2iwgB:
undetectable		 3ax7B-2iwgB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jb1 L-AMINO ACID OXIDASE

(Rhodococcus
opacus) 		PF01593
(Amino_oxidase) 		5 THR A 311
VAL A 309
LEU A 447
ALA A 316
ALA A 315
 None
 1.20A 3ax7B-2jb1A:
undetectable		 3ax7B-2jb1A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 528
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.41A 3ax7B-2w55B:
51.4		 3ax7B-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		5 THR C 159
VAL C 158
LEU C  55
ALA C 152
ALA C  59
 None
 1.39A 3ax7B-2wy0C:
undetectable		 3ax7B-2wy0C:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		5 SER A  47
ARG A  51
THR A  21
LEU A  41
ALA A  53
 None
 1.40A 3ax7B-2x4gA:
undetectable		 3ax7B-2x4gA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8x TLR1789 PROTEIN

(Thermosynechococcus
elongatus) 		PF07244
(POTRA)
PF08479
(POTRA_2) 		5 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.37A 3ax7B-2x8xX:
undetectable		 3ax7B-2x8xX:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Deinococcus
geothermalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 ARG A  31
THR A  29
VAL A  28
LEU A 106
ALA A  48
 None
 1.45A 3ax7B-3e97A:
undetectable		 3ax7B-3e97A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		5 GLU A 258
ARG A 313
VAL A 307
ALA A 362
ALA A 361
 None
 1.30A 3ax7B-3gseA:
undetectable		 3ax7B-3gseA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 ARG C 185
THR C 164
LEU C 152
ALA C 161
ALA C 162
 None
 1.02A 3ax7B-3gzdC:
undetectable		 3ax7B-3gzdC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg PERMEASE
MOLYBDATE-BINDING
PERIPLASMIC PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 ARG A 134
VAL A 142
LEU A 115
ALA A 129
ALA A 130
 SO4  A1403 (-2.8A)
None
None
None
SO4  A1403 ( 4.0A)
 1.25A 3ax7B-3gzgA:
undetectable		 3ax7B-3gzgA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj9 OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		PF00881
(Nitroreductase) 		5 SER A  86
ARG A  82
THR A  91
VAL A  92
ALA A  72
 None
 1.45A 3ax7B-3hj9A:
0.5		 3ax7B-3hj9A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix7 UNCHARACTERIZED
PROTEIN TTHA0540

(Thermus
thermophilus) 		no annotation 5 ARG A 202
VAL A 155
LEU A 164
ALA A 206
ALA A 160
 None
 1.38A 3ax7B-3ix7A:
undetectable		 3ax7B-3ix7A:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pn1 DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		5 ARG A 209
THR A 136
VAL A 122
ALA A 204
ALA A 205
 None
 1.27A 3ax7B-3pn1A:
undetectable		 3ax7B-3pn1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 THR A 189
VAL A 190
LEU A 191
ALA A  49
ALA A  53
 None
 1.26A 3ax7B-3qp9A:
undetectable		 3ax7B-3qp9A:
17.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		9 GLU C 802
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1078
ALA C1079
 RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
 0.24A 3ax7B-3sr6C:
63.0		 3ax7B-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10) 		5 ARG A 491
THR A 507
VAL A 520
LEU A 534
ALA A 553
 None
 1.46A 3ax7B-3wsyA:
undetectable		 3ax7B-3wsyA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE,
IRON-SULFUR PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD) 		5 THR B 276
VAL B 277
LEU B 213
ALA B 253
ALA B 250
 None
 1.07A 3ax7B-4c1nB:
0.6		 3ax7B-4c1nB:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.45A 3ax7B-4cnsA:
undetectable		 3ax7B-4cnsA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.41A 3ax7B-4cntA:
undetectable		 3ax7B-4cntA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 SER A 285
THR A 317
VAL A 318
LEU A 352
ALA A 314
 None
 1.01A 3ax7B-4dyjA:
undetectable		 3ax7B-4dyjA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqx KETOL-ACID
REDUCTOISOMERASE

(Slackia exigua) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 THR A 113
VAL A 133
LEU A 108
ALA A  81
ALA A  84
 None
 1.43A 3ax7B-4kqxA:
undetectable		 3ax7B-4kqxA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nle ADENYLOSUCCINATE
LYASE

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 ARG A 131
VAL A 455
LEU A 458
ALA A 465
ALA A 466
 None
 1.30A 3ax7B-4nleA:
undetectable		 3ax7B-4nleA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2h PROLINE RACEMASE
PROTEIN

(Agrobacterium
tumefaciens) 		PF05544
(Pro_racemase) 		5 SER A  97
PHE A  81
VAL A 128
ALA A  79
ALA A  80
 None
 1.49A 3ax7B-4q2hA:
undetectable		 3ax7B-4q2hA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlp CHYMOTRYPSIN
INHIBITOR 3

(Psophocarpus
tetragonolobus) 		PF00197
(Kunitz_legume) 		5 PHE A  82
THR A  36
VAL A  49
LEU A 163
ALA A  94
 None
 1.49A 3ax7B-4tlpA:
undetectable		 3ax7B-4tlpA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7l TYPE VI SECRETION
PROTEIN ICMF

(Escherichia
coli) 		PF06744
(IcmF_C) 		5 ARG A 880
THR A1104
VAL A1105
LEU A 875
ALA A 877
 None
 1.46A 3ax7B-4y7lA:
undetectable		 3ax7B-4y7lA:
10.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		8 GLU A 802
SER A 876
ARG A 880
PHE A 914
THR A1010
LEU A1014
ALA A1078
ALA A1079
 URC  A3007 (-3.0A)
None
URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
None
URC  A3007 (-3.5A)
URC  A3007 (-3.4A)
 0.32A 3ax7B-4yswA:
44.3		 3ax7B-4yswA:
86.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpr DNA LIGASE

(Staphylococcus
aureus) 		PF01653
(DNA_ligase_aden) 		5 ARG A 202
THR A 132
VAL A 118
ALA A 197
ALA A 198
 None
 1.25A 3ax7B-5fprA:
undetectable		 3ax7B-5fprA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 ARG B 377
THR B 379
VAL B 380
LEU B 402
ALA B 417
 None
 1.25A 3ax7B-5gztB:
undetectable		 3ax7B-5gztB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		5 THR A 346
VAL A 347
LEU A 348
ALA A 375
ALA A 357
 None
 1.10A 3ax7B-5j8qA:
undetectable		 3ax7B-5j8qA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans) 		PF04261
(Dyp_perox) 		5 SER A 122
ARG A 119
VAL A 438
ALA A 114
ALA A 115
 None
 1.33A 3ax7B-5mapA:
0.7		 3ax7B-5mapA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 ARG A 304
THR A 142
VAL A 141
LEU A 249
ALA A 272
 None
 1.45A 3ax7B-5mscA:
undetectable		 3ax7B-5mscA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbr DEOXYRIBOSYLTRANSFER
ASE

(Leishmania
mexicana) 		PF05014
(Nuc_deoxyrib_tr) 		5 PHE A  99
VAL A  27
LEU A  30
ALA A 143
ALA A 144
 None
 1.40A 3ax7B-5nbrA:
undetectable		 3ax7B-5nbrA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 5 PHE A  98
VAL A 497
LEU A 440
ALA A 442
ALA A  95
 None
 1.48A 3ax7B-5oasA:
undetectable		 3ax7B-5oasA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.47A 3ax7B-5uqcA:
undetectable		 3ax7B-5uqcA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyo THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Burkholderia
pseudomallei) 		no annotation 5 ARG A  68
PHE A  39
THR A  97
VAL A 100
ALA A  46
 None
 1.26A 3ax7B-5vyoA:
undetectable		 3ax7B-5vyoA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gu8 -

(-) 		no annotation 5 SER A 134
THR A 140
VAL A 141
LEU A 116
ALA A 150
 EDO  A 505 ( 4.8A)
None
None
None
EDO  A 506 (-3.1A)
 1.46A 3ax7B-6gu8A:
0.7		 3ax7B-6gu8A:
undetectable