SIMILAR PATTERNS OF AMINO ACIDS FOR 3AX7_A_SALA1336_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqu ISOCITRATE LYASE

(Aspergillus
nidulans) 		PF00463
(ICL) 		4 SER A 101
THR A 122
VAL A 123
ALA A 116
 None
 0.91A 3ax7A-1dquA:
0.0		 3ax7A-1dquA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta) 		PF02763
(Diphtheria_C) 		4 SER A  19
PHE A  17
VAL A  83
LEU A 159
 None
 0.99A 3ax7A-1dtpA:
0.0		 3ax7A-1dtpA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN

(Mus musculus) 		PF06482
(Endostatin) 		4 PHE A 106
THR A 117
LEU A 115
ALA A 109
 None
 0.95A 3ax7A-1dy2A:
0.0		 3ax7A-1dy2A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 SER A 472
ARG A 476
VAL A 511
ALA A 502
 None
 0.85A 3ax7A-1gpeA:
0.0		 3ax7A-1gpeA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsk UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Staphylococcus
aureus) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 SER A 255
THR A 296
VAL A 297
LEU A 305
 None
 1.01A 3ax7A-1hskA:
8.0		 3ax7A-1hskA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvm CATALYTIC DOMAIN OF
THE NUCLEAR
INCLUSION PROTEIN A
(NIA)

(Tobacco etch
virus) 		PF00863
(Peptidase_C4) 		4 SER A  59
PHE A 116
VAL A  57
LEU A  21
 None
 1.03A 3ax7A-1lvmA:
0.0		 3ax7A-1lvmA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 GLU B 266
THR B 273
VAL B 274
LEU B 271
 None
 1.02A 3ax7A-1mhyB:
0.0		 3ax7A-1mhyB:
14.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		8 GLU A 802
SER A 876
ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.30A 3ax7A-1n5xA:
44.4		 3ax7A-1n5xA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 SER A 876
PHE A 914
VAL A1011
LEU A1014
ALA A1078
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-4.8A)
None
MOS  A3004 (-3.0A)
 1.12A 3ax7A-1n5xA:
44.4		 3ax7A-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 ARG A 171
VAL A  62
LEU A  66
ALA A 162
 None
 1.00A 3ax7A-1oa1A:
0.0		 3ax7A-1oa1A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 THR A 411
VAL A 459
LEU A 476
ALA A 427
 None
 0.93A 3ax7A-1pbyA:
2.2		 3ax7A-1pbyA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 SER A  47
THR A  50
VAL A  51
ALA A  35
 None
 0.94A 3ax7A-1q5nA:
undetectable		 3ax7A-1q5nA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE

(Mus musculus) 		PF02348
(CTP_transf_3) 		4 PHE A  83
VAL A  73
LEU A 147
ALA A  80
 None
 0.93A 3ax7A-1qwjA:
undetectable		 3ax7A-1qwjA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M) 		4 PHE A 168
VAL A 253
LEU A 160
ALA A 165
 None
 0.93A 3ax7A-1t98A:
2.8		 3ax7A-1t98A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		4 PHE A 642
VAL A 683
LEU A 690
ALA A 694
 None
 0.98A 3ax7A-1u2lA:
undetectable		 3ax7A-1u2lA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 ARG A 118
VAL A 134
LEU A 129
ALA A 121
 None
 1.01A 3ax7A-1us4A:
undetectable		 3ax7A-1us4A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 THR A 123
VAL A 122
LEU A 146
ALA A 111
 None
 1.02A 3ax7A-1v0zA:
undetectable		 3ax7A-1v0zA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ARG A 209
THR A 138
VAL A 124
ALA A 205
 None
 1.01A 3ax7A-1v9pA:
undetectable		 3ax7A-1v9pA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 378
VAL A 366
LEU A 382
ALA A 379
 None
 1.01A 3ax7A-1wytA:
undetectable		 3ax7A-1wytA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfl THIOREDOXIN H1

(Arabidopsis
thaliana) 		PF00085
(Thioredoxin) 		4 PHE A  50
VAL A  31
LEU A  61
ALA A  54
 None
 1.02A 3ax7A-1xflA:
undetectable		 3ax7A-1xflA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 SER A 120
ARG A 117
VAL A 137
LEU A 151
ALA A 170
 None
 1.39A 3ax7A-1yr2A:
1.5		 3ax7A-1yr2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL
PYRUVATE
DEHYDROGENASE
PROTEIN X COMPONENT,
MITOCHONDRIAL

(Homo sapiens) 		PF02817
(E3_binding)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLU A 443
VAL K 167
LEU K 164
ALA K 135
 None
 0.95A 3ax7A-1zy8A:
undetectable		 3ax7A-1zy8A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 ARG A  94
THR A 150
VAL A 151
ALA A  57
 None
 0.99A 3ax7A-2d1gA:
undetectable		 3ax7A-2d1gA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		4 SER A  52
PHE A  49
VAL A  54
ALA A 214
 None
 1.01A 3ax7A-2fbvA:
1.3		 3ax7A-2fbvA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 SER A 206
VAL A 202
LEU A 191
ALA A 231
 None
 0.99A 3ax7A-2gkoA:
undetectable		 3ax7A-2gkoA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpy O-METHYLTRANSFERASE

(Bacillus
halodurans) 		PF01596
(Methyltransf_3) 		4 SER A  68
ARG A  71
LEU A  50
ALA A  75
 None
 0.91A 3ax7A-2gpyA:
undetectable		 3ax7A-2gpyA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsm GLUTAMYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Saccharomyces
cerevisiae) 		no annotation 4 GLU A  36
SER A 148
VAL A 105
ALA A 141
 None
 0.95A 3ax7A-2hsmA:
undetectable		 3ax7A-2hsmA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Thermus
thermophilus) 		PF05690
(ThiG) 		4 SER A  19
THR A  41
VAL A  42
LEU A  66
 None
 0.94A 3ax7A-2htmA:
undetectable		 3ax7A-2htmA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iod DIHYDROFLAVONOL
4-REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		4 SER A 205
VAL A 193
LEU A 231
ALA A 315
 NAP  A1340 ( 3.0A)
NAP  A1340 (-3.9A)
None
None
 0.88A 3ax7A-2iodA:
undetectable		 3ax7A-2iodA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwg 52 KDA RO PROTEIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 ARG B 160
THR B  12
VAL B  48
LEU B   8
ALA B  51
 None
 1.44A 3ax7A-2iwgB:
undetectable		 3ax7A-2iwgB:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 GLU A 379
ARG A 371
VAL A 342
LEU A 340
 None
 0.95A 3ax7A-2iyfA:
undetectable		 3ax7A-2iyfA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knq GENERAL SECRETION
PATHWAY PROTEIN H

(Escherichia
coli) 		PF12019
(GspH) 		4 SER A  34
VAL A  51
LEU A  64
ALA A  27
 None
 1.01A 3ax7A-2knqA:
undetectable		 3ax7A-2knqA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n57 ACYL CARRIER PROTEIN

(Brucella
melitensis) 		PF00550
(PP-binding) 		4 THR A  40
VAL A  41
LEU A  38
ALA A  35
 None
 0.97A 3ax7A-2n57A:
undetectable		 3ax7A-2n57A:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og2 PUTATIVE SIGNAL
RECOGNITION PARTICLE
RECEPTOR

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 THR A 196
VAL A 197
LEU A 198
ALA A 237
 None
 1.02A 3ax7A-2og2A:
undetectable		 3ax7A-2og2A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		4 SER A  31
PHE A  88
VAL A  81
ALA A  87
 None
 0.96A 3ax7A-2ps3A:
0.9		 3ax7A-2ps3A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 PHE A 132
THR A 310
VAL A 311
LEU A 304
 None
 0.97A 3ax7A-2q6uA:
undetectable		 3ax7A-2q6uA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql8 PUTATIVE REDOX
PROTEIN

(Lactobacillus
paracasei) 		PF02566
(OsmC) 		4 SER A  54
VAL A 122
LEU A 126
ALA A  97
 None
 0.99A 3ax7A-2ql8A:
undetectable		 3ax7A-2ql8A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 ARG A 282
THR A 194
VAL A 193
LEU A 232
 None
 0.95A 3ax7A-2rgjA:
undetectable		 3ax7A-2rgjA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 280
SER A 168
PHE A 261
LEU A 162
 None
 0.99A 3ax7A-2uxtA:
undetectable		 3ax7A-2uxtA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.43A 3ax7A-2w55B:
49.9		 3ax7A-2w55B:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 GLU A 458
SER A 614
THR A 571
ALA A 431
 None
 0.98A 3ax7A-2xaxA:
undetectable		 3ax7A-2xaxA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		4 SER A 180
THR A 388
VAL A 389
ALA A 281
 None
 0.90A 3ax7A-3a2qA:
undetectable		 3ax7A-3a2qA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ARG A 178
VAL A  12
LEU A 232
ALA A 171
 None
 1.02A 3ax7A-3a5rA:
undetectable		 3ax7A-3a5rA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 103
THR A 101
VAL A 100
LEU A  91
 SO4  A 249 (-3.2A)
SO4  A 249 ( 4.1A)
None
None
 1.02A 3ax7A-3aizA:
undetectable		 3ax7A-3aizA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Geobacillus
kaustophilus) 		PF00551
(Formyl_trans_N) 		4 THR A 180
VAL A 181
LEU A 182
ALA A  21
 None
 0.86A 3ax7A-3av3A:
undetectable		 3ax7A-3av3A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		4 PHE A  81
THR A  63
VAL A  66
LEU A  71
 None
 1.01A 3ax7A-3bujA:
undetectable		 3ax7A-3bujA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		4 GLU A  79
ARG A 166
VAL A 126
LEU A 103
 None
MT2  A 501 (-3.1A)
None
None
 0.71A 3ax7A-3c8fA:
undetectable		 3ax7A-3c8fA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ARG A 140
THR A 138
VAL A 137
LEU A 150
 None
 0.96A 3ax7A-3ecqA:
undetectable		 3ax7A-3ecqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY

(Bacillus
anthracis) 		PF02567
(PhzC-PhzF) 		4 SER A 141
VAL A 188
LEU A 189
ALA A 219
 None
 0.80A 3ax7A-3ednA:
undetectable		 3ax7A-3ednA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		4 GLU A 288
THR A  47
VAL A  48
LEU A  49
 None
 0.96A 3ax7A-3ez1A:
undetectable		 3ax7A-3ez1A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		4 THR A  17
VAL A  18
LEU A  14
ALA A 343
 None
 1.02A 3ax7A-3ffrA:
undetectable		 3ax7A-3ffrA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxa SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 SER A 165
THR A  28
VAL A 142
ALA A  32
 None
 0.74A 3ax7A-3fxaA:
undetectable		 3ax7A-3fxaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Escherichia
coli) 		PF00936
(BMC) 		4 PHE A 189
VAL A 152
LEU A 125
ALA A 149
 None
None
None
HG  A 800 (-2.4A)
 0.97A 3ax7A-3gfhA:
undetectable		 3ax7A-3gfhA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grc SENSOR PROTEIN,
KINASE

(Polaromonas sp.
JS666) 		PF00072
(Response_reg) 		4 GLU A 633
VAL A 626
LEU A 599
ALA A 629
 None
 1.02A 3ax7A-3grcA:
undetectable		 3ax7A-3grcA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 ARG C 185
THR C 164
LEU C 152
ALA C 162
 None
 1.00A 3ax7A-3gzdC:
undetectable		 3ax7A-3gzdC:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0z PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Streptococcus
pneumoniae) 		PF01380
(SIS) 		4 SER A 114
THR A 127
VAL A 128
LEU A 125
 None
 0.88A 3ax7A-3i0zA:
undetectable		 3ax7A-3i0zA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
furiosus) 		PF07969
(Amidohydro_3) 		4 SER A  98
THR A 476
VAL A 475
ALA A 344
 None
None
None
KCX  A 294 ( 4.1A)
 0.86A 3ax7A-3icjA:
undetectable		 3ax7A-3icjA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF1A

(Saccharomyces
cerevisiae) 		PF01201
(Ribosomal_S8e) 		4 GLU i  34
VAL i  92
LEU i  78
ALA i  36
 None
 0.85A 3ax7A-3japi:
undetectable		 3ax7A-3japi:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 472
SER A 350
PHE A 260
ALA A 424
 None
 0.84A 3ax7A-3jq0A:
undetectable		 3ax7A-3jq0A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 448
SER A 336
PHE A 251
ALA A 423
 None
 0.96A 3ax7A-3jq1A:
undetectable		 3ax7A-3jq1A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8o IMMUNOGLOBULIN A1
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG H 170
THR H 168
VAL H 167
LEU H 191
 None
 0.95A 3ax7A-3m8oH:
undetectable		 3ax7A-3m8oH:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		4 THR A 374
VAL A 373
LEU A 313
ALA A 360
 None
 0.89A 3ax7A-3memA:
undetectable		 3ax7A-3memA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mml ALLOPHANATE
HYDROLASE SUBUNIT 2

(Mycolicibacterium
smegmatis) 		PF02626
(CT_A_B) 		4 SER A 206
THR A 203
VAL A 202
LEU A 213
 None
 1.02A 3ax7A-3mmlA:
undetectable		 3ax7A-3mmlA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		4 SER A 512
PHE A 508
VAL A 602
LEU A 599
 None
 0.94A 3ax7A-3odwA:
undetectable		 3ax7A-3odwA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		4 ARG A 156
VAL A 209
LEU A 149
ALA A 153
 None
 0.99A 3ax7A-3oqbA:
undetectable		 3ax7A-3oqbA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		4 SER A 258
ARG A 257
LEU A 251
ALA A 292
 None
 1.02A 3ax7A-3oyrA:
undetectable		 3ax7A-3oyrA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyz MALATE SYNTHASE

(Haloferax
volcanii) 		PF03328
(HpcH_HpaI) 		4 GLU A  80
VAL A 226
LEU A 185
ALA A 152
 None
CL  A 705 ( 4.0A)
None
None
 0.93A 3ax7A-3oyzA:
undetectable		 3ax7A-3oyzA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 0.94A 3ax7A-3pblA:
undetectable		 3ax7A-3pblA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.00A 3ax7A-3pdsA:
undetectable		 3ax7A-3pdsA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 THR A 189
VAL A 190
LEU A 191
ALA A  53
 None
 0.80A 3ax7A-3qp9A:
undetectable		 3ax7A-3qp9A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5t FERRIC VIBRIOBACTIN
ABC TRANSPORTER,
PERIPLASMIC FERRIC
VIBRIOBACTIN-BINDING
PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		4 SER A  56
THR A  62
VAL A  61
ALA A  70
 None
 0.92A 3ax7A-3r5tA:
undetectable		 3ax7A-3r5tA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		4 ARG A  66
VAL A  98
LEU A  93
ALA A  62
 None
 0.82A 3ax7A-3rg2A:
undetectable		 3ax7A-3rg2A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 SER A 299
ARG A 275
VAL A 172
LEU A 291
 None
 1.02A 3ax7A-3s8dA:
undetectable		 3ax7A-3s8dA:
15.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		8 GLU C 802
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
 RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
 0.17A 3ax7A-3sr6C:
61.6		 3ax7A-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 SER C 876
PHE C 914
VAL C1011
LEU C1014
ALA C1078
 None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
 1.11A 3ax7A-3sr6C:
61.6		 3ax7A-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ARG A 537
THR A 534
VAL A 535
LEU A 514
 None
 0.92A 3ax7A-3sucA:
undetectable		 3ax7A-3sucA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		4 SER A 118
THR A 370
LEU A 372
ALA A 374
 QPA  A 117 ( 2.9A)
None
EPZ  A 508 (-4.2A)
None
 0.96A 3ax7A-3sweA:
undetectable		 3ax7A-3sweA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		4 SER A 125
THR A 374
LEU A 376
ALA A 378
 QPA  A 124 ( 3.3A)
None
EPZ  A 518 (-4.4A)
None
 0.96A 3ax7A-3swgA:
undetectable		 3ax7A-3swgA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfw PUTATIVE
O-METHYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF01596
(Methyltransf_3) 		4 ARG A 118
THR A 116
VAL A 115
LEU A  89
 None
 0.99A 3ax7A-3tfwA:
undetectable		 3ax7A-3tfwA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 SER A 255
THR A 259
LEU A 115
ALA A 247
 None
 0.79A 3ax7A-3tktA:
undetectable		 3ax7A-3tktA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Listeria
monocytogenes) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 SER A 237
THR A 278
VAL A 279
LEU A 287
 None
 0.99A 3ax7A-3tx1A:
7.5		 3ax7A-3tx1A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 PHE A 699
VAL A 740
LEU A 747
ALA A 751
 None
 0.96A 3ax7A-3ut2A:
undetectable		 3ax7A-3ut2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 0.99A 3ax7A-3v2yA:
undetectable		 3ax7A-3v2yA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		4 SER A 144
PHE A  86
VAL A 142
ALA A  84
 None
 1.00A 3ax7A-3welA:
undetectable		 3ax7A-3welA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzi UNCHARACTERIZED
PROTEIN AF_1864

(Archaeoglobus
fulgidus) 		PF09620
(Cas_csx3) 		4 SER A  44
ARG A  46
VAL A  93
LEU A  97
 A  C   3 ( 4.4A)
A  C   3 ( 4.5A)
None
None
 1.01A 3ax7A-3wziA:
undetectable		 3ax7A-3wziA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 THR A 793
VAL A 792
LEU A 752
ALA A 761
 None
 1.02A 3ax7A-4a4zA:
undetectable		 3ax7A-4a4zA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		4 PHE B  56
THR A1755
VAL A1754
LEU A1757
 None
 0.81A 3ax7A-4by6B:
undetectable		 3ax7A-4by6B:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE,
IRON-SULFUR PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD) 		4 THR B 276
VAL B 277
LEU B 213
ALA B 250
 None
 0.98A 3ax7A-4c1nB:
undetectable		 3ax7A-4c1nB:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 SER A 488
ARG A 487
LEU A 471
ALA A 475
 None
 0.88A 3ax7A-4c7gA:
undetectable		 3ax7A-4c7gA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2o PER-2 BETA-LACTAMASE

(Citrobacter
freundii) 		PF13354
(Beta-lactamase2) 		4 PHE A 264
VAL A 189
LEU A 190
ALA A  47
 None
 0.99A 3ax7A-4d2oA:
undetectable		 3ax7A-4d2oA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		4 PHE A 391
VAL A 412
LEU A 416
ALA A 387
 None
 0.84A 3ax7A-4d3yA:
undetectable		 3ax7A-4d3yA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 SER A 285
THR A 317
VAL A 318
LEU A 352
 None
 0.96A 3ax7A-4dyjA:
undetectable		 3ax7A-4dyjA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ea1 DEHYDROSQUALENE
SYNTHASE

(Staphylococcus
aureus) 		PF00494
(SQS_PSY) 		4 ARG A 158
VAL A 140
LEU A 141
ALA A 157
 None
 0.93A 3ax7A-4ea1A:
undetectable		 3ax7A-4ea1A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eca L-ASPARAGINE
AMIDOHYDROLASE

(Escherichia
coli) 		PF00710
(Asparaginase) 		4 SER A 271
ARG A 269
THR A 278
ALA A 282
 None
 1.00A 3ax7A-4ecaA:
undetectable		 3ax7A-4ecaA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 SER A 112
ARG A 229
THR A 232
LEU A 244
 None
 1.00A 3ax7A-4gpgA:
undetectable		 3ax7A-4gpgA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhq SERUM PARAOXONASE BY
DIRECTED EVOLUTION

(synthetic
construct) 		PF01731
(Arylesterase) 		4 GLU A  56
VAL A 131
LEU A 129
ALA A 172
 None
 0.91A 3ax7A-4hhqA:
undetectable		 3ax7A-4hhqA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7l LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 IPH  A 202 (-4.4A)
IPH  A 202 ( 4.4A)
None
None
 1.02A 3ax7A-4i7lA:
undetectable		 3ax7A-4i7lA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg9 LIPOPROTEIN

(Bacillus
anthracis) 		PF16167
(DUF4871) 		4 THR A 115
VAL A 114
LEU A  47
ALA A  41
 None
 1.00A 3ax7A-4jg9A:
undetectable		 3ax7A-4jg9A:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1

(Staphylococcus
aureus) 		PF13614
(AAA_31) 		4 GLU A1049
VAL A1208
LEU A1179
ALA A1053
 None
None
None
ADP  A1301 (-3.9A)
 1.01A 3ax7A-4jlvA:
undetectable		 3ax7A-4jlvA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 463
SER A 343
PHE A 253
ALA A 417
 None
 0.81A 3ax7A-4l7tA:
undetectable		 3ax7A-4l7tA:
17.53