SIMILAR PATTERNS OF AMINO ACIDS FOR 3ASO_W_CHDW1059

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 ILE A 148
PHE A 144
ARG A 229
LEU A 231
 None
 0.91A 3asoN-1brtA:
0.0
3asoW-1brtA:
0.0		 3asoN-1brtA:
20.34
3asoW-1brtA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1j PROFILIN II

(Homo sapiens) 		PF00235
(Profilin) 		4 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.89A 3asoN-1d1jA:
undetectable
3asoW-1d1jA:
undetectable		 3asoN-1d1jA:
15.87
3asoW-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		5 ILE A 350
ARG A 308
MET A 311
THR A 312
LEU A 315
 None
 1.07A 3asoN-1floA:
0.3
3asoW-1floA:
0.0		 3asoN-1floA:
21.78
3asoW-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.91A 3asoN-1gl6A:
0.2
3asoW-1gl6A:
undetectable		 3asoN-1gl6A:
21.30
3asoW-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.71A 3asoN-1harA:
undetectable
3asoW-1harA:
0.0		 3asoN-1harA:
18.00
3asoW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ILE A 129
LEU A 181
TYR A 190
LEU A 104
 None
None
None
MLZ  A 105 ( 4.3A)
 0.90A 3asoN-1iv8A:
0.0
3asoW-1iv8A:
0.0		 3asoN-1iv8A:
20.68
3asoW-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.94A 3asoN-1jedA:
0.0
3asoW-1jedA:
0.0		 3asoN-1jedA:
21.17
3asoW-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A  53
PHE A 104
ARG A 138
THR A 142
LEU A 144
 None
 1.34A 3asoN-1knrA:
2.3
3asoW-1knrA:
0.0		 3asoN-1knrA:
20.83
3asoW-1knrA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.82A 3asoN-1kt8A:
0.0
3asoW-1kt8A:
0.0		 3asoN-1kt8A:
22.71
3asoW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2m REP PROTEIN

(Tomato yellow
leaf curl
Sardinia virus) 		PF00799
(Gemini_AL1) 		4 ILE A   9
PHE A   7
THR A  17
LEU A  16
 None
 0.89A 3asoN-1l2mA:
undetectable
3asoW-1l2mA:
undetectable		 3asoN-1l2mA:
10.72
3asoW-1l2mA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw5 HYPOTHETICAL PROTEIN
HI1480

(Haemophilus
influenzae) 		no annotation 5 ILE A 135
LEU A  62
PHE A 131
THR A  32
LEU A  34
 None
 1.26A 3asoN-1mw5A:
0.0
3asoW-1mw5A:
undetectable		 3asoN-1mw5A:
15.69
3asoW-1mw5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no8 ALY

(Mus musculus) 		PF00076
(RRM_1) 		5 ILE A 121
LEU A 124
PHE A 125
MET A 175
LEU A 170
 None
 1.24A 3asoN-1no8A:
undetectable
3asoW-1no8A:
undetectable		 3asoN-1no8A:
11.24
3asoW-1no8A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 PHE A 106
MET A 210
THR A 211
LEU A 214
 HEM  A1407 (-4.5A)
None
None
None
 0.90A 3asoN-1odoA:
undetectable
3asoW-1odoA:
undetectable		 3asoN-1odoA:
23.13
3asoW-1odoA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		5 ILE A 335
LEU A 339
TYR A 310
ARG A 328
THR A 312
 None
None
None
HG  A 614 ( 4.9A)
None
 1.24A 3asoN-1pm2A:
undetectable
3asoW-1pm2A:
undetectable		 3asoN-1pm2A:
19.19
3asoW-1pm2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.95A 3asoN-1r6xA:
undetectable
3asoW-1r6xA:
undetectable		 3asoN-1r6xA:
21.48
3asoW-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxm DNA POLYMERASE
SLIDING CLAMP

(Archaeoglobus
fulgidus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ILE A  27
LEU A  34
PHE A  29
LEU A  11
 None
 0.92A 3asoN-1rxmA:
undetectable
3asoW-1rxmA:
undetectable		 3asoN-1rxmA:
19.33
3asoW-1rxmA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		4 LEU A 261
PHE A 262
THR A 230
LEU A 229
 None
 0.83A 3asoN-1skaA:
undetectable
3asoW-1skaA:
undetectable		 3asoN-1skaA:
19.89
3asoW-1skaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 LEU A 151
PHE A 154
MET A 225
LEU A 229
 None
 0.92A 3asoN-1su7A:
undetectable
3asoW-1su7A:
undetectable		 3asoN-1su7A:
22.01
3asoW-1su7A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdh NEI ENDONUCLEASE
VIII-LIKE 1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		4 ILE A  47
LEU A 112
PHE A 101
LEU A  56
 None
 0.92A 3asoN-1tdhA:
undetectable
3asoW-1tdhA:
undetectable		 3asoN-1tdhA:
20.00
3asoW-1tdhA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 ILE A 361
PHE A 287
ARG A 310
MET A 294
THR A 295
 None
 1.46A 3asoN-1v43A:
undetectable
3asoW-1v43A:
undetectable		 3asoN-1v43A:
21.39
3asoW-1v43A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00215
(OMPdecase) 		4 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.83A 3asoN-1vqtA:
undetectable
3asoW-1vqtA:
undetectable		 3asoN-1vqtA:
17.18
3asoW-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ILE A 250
LEU A 253
ARG A 211
LEU A 204
 None
 0.82A 3asoN-1w1kA:
undetectable
3asoW-1w1kA:
undetectable		 3asoN-1w1kA:
22.15
3asoW-1w1kA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn0 HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN

(Zea mays) 		PF01627
(Hpt) 		5 LEU A  30
PHE A  27
MET A 134
THR A 133
LEU A 135
 None
 1.36A 3asoN-1wn0A:
2.7
3asoW-1wn0A:
undetectable		 3asoN-1wn0A:
13.04
3asoW-1wn0A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 ILE A 192
LEU A 273
PHE A 274
LEU A 211
 None
 0.82A 3asoN-1xl8A:
2.2
3asoW-1xl8A:
undetectable		 3asoN-1xl8A:
19.90
3asoW-1xl8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE

(Moorella
thermoacetica) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ILE A 367
LEU A 340
ARG A 305
LEU A 277
 None
 0.83A 3asoN-1ycgA:
undetectable
3asoW-1ycgA:
undetectable		 3asoN-1ycgA:
22.05
3asoW-1ycgA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		4 ILE X 178
LEU X 181
ARG X  95
LEU X 102
 None
 0.88A 3asoN-1zv4X:
undetectable
3asoW-1zv4X:
undetectable		 3asoN-1zv4X:
13.67
3asoW-1zv4X:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		4 ILE A  67
LEU A  23
THR A  18
LEU A  17
 None
 0.89A 3asoN-1zypA:
undetectable
3asoW-1zypA:
undetectable		 3asoN-1zypA:
16.98
3asoW-1zypA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 LEU A 227
TYR A  72
THR A  77
LEU A  80
 None
 0.70A 3asoN-2b9bA:
1.5
3asoW-2b9bA:
2.5		 3asoN-2b9bA:
21.63
3asoW-2b9bA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhv COMB10

(Helicobacter
pylori) 		PF03743
(TrbI) 		4 ILE A 212
PHE A 362
ARG A 239
LEU A 282
 None
 0.91A 3asoN-2bhvA:
undetectable
3asoW-2bhvA:
undetectable		 3asoN-2bhvA:
19.84
3asoW-2bhvA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		4 LEU A  39
PHE A  37
ARG A  21
LEU A  15
 None
 0.85A 3asoN-2cfoA:
undetectable
3asoW-2cfoA:
undetectable		 3asoN-2cfoA:
21.24
3asoW-2cfoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		5 ILE A  36
LEU A  40
ARG A  17
THR A 198
LEU A 202
 None
 1.23A 3asoN-2d5wA:
1.5
3asoW-2d5wA:
undetectable		 3asoN-2d5wA:
20.31
3asoW-2d5wA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36

(Mus musculus) 		PF11605
(Vps36_ESCRT-II) 		5 ILE A  82
LEU A 108
PHE A 110
ARG A 120
LEU A  42
 None
 1.22A 3asoN-2dx5A:
undetectable
3asoW-2dx5A:
undetectable		 3asoN-2dx5A:
12.45
3asoW-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efj 3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A 373
LEU A 223
PHE A 225
THR A 201
 None
 0.90A 3asoN-2efjA:
undetectable
3asoW-2efjA:
undetectable		 3asoN-2efjA:
22.83
3asoW-2efjA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 3asoN-2eg5A:
undetectable
3asoW-2eg5A:
undetectable		 3asoN-2eg5A:
22.14
3asoW-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		5 ILE A 118
PHE A 126
MET A 167
THR A 165
LEU A 164
 None
 1.45A 3asoN-2g9bA:
undetectable
3asoW-2g9bA:
undetectable		 3asoN-2g9bA:
16.24
3asoW-2g9bA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghs AGR_C_1268P

(Agrobacterium
fabrum) 		PF08450
(SGL) 		5 ILE A 151
LEU A 162
PHE A 163
THR A 180
LEU A 196
 None
 1.24A 3asoN-2ghsA:
undetectable
3asoW-2ghsA:
undetectable		 3asoN-2ghsA:
21.64
3asoW-2ghsA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.75A 3asoN-2hnzA:
1.9
3asoW-2hnzA:
undetectable		 3asoN-2hnzA:
19.77
3asoW-2hnzA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE A   9
ARG A 108
THR A  43
LEU A  42
 None
 0.90A 3asoN-2idcA:
undetectable
3asoW-2idcA:
undetectable		 3asoN-2idcA:
13.97
3asoW-2idcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzn MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT

(Escherichia
coli) 		PF03610
(EIIA-man) 		4 ILE A   3
LEU A 114
PHE A 111
LEU A  65
 None
 0.87A 3asoN-2jznA:
undetectable
3asoW-2jznA:
undetectable		 3asoN-2jznA:
15.94
3asoW-2jznA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.78A 3asoN-2kbqA:
undetectable
3asoW-2kbqA:
undetectable		 3asoN-2kbqA:
8.84
3asoW-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knh PROTEIN CBFA2T1

(Homo sapiens) 		PF07531
(TAFH) 		4 LEU A 333
PHE A 332
THR A 279
LEU A 278
 None
 0.91A 3asoN-2knhA:
undetectable
3asoW-2knhA:
undetectable		 3asoN-2knhA:
11.32
3asoW-2knhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la7 UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF03724
(META) 		4 LEU A 112
ARG A 117
THR A 137
LEU A 138
 None
 0.80A 3asoN-2la7A:
undetectable
3asoW-2la7A:
undetectable		 3asoN-2la7A:
14.14
3asoW-2la7A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		4 ILE A  53
PHE A  79
THR A  97
LEU A  95
 None
 0.92A 3asoN-2o6qA:
undetectable
3asoW-2o6qA:
undetectable		 3asoN-2o6qA:
18.29
3asoW-2o6qA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.73A 3asoN-2p0dA:
undetectable
3asoW-2p0dA:
undetectable		 3asoN-2p0dA:
12.67
3asoW-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE X 252
MET X 356
THR X 357
LEU X 360
 None
 0.85A 3asoN-2p3gX:
undetectable
3asoW-2p3gX:
undetectable		 3asoN-2p3gX:
19.81
3asoW-2p3gX:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 LEU A 128
PHE A 137
TYR A  58
LEU A 163
 None
 0.77A 3asoN-2p3xA:
undetectable
3asoW-2p3xA:
undetectable		 3asoN-2p3xA:
19.17
3asoW-2p3xA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 ILE A 250
PHE A 192
ARG A 272
THR A 275
 None
 0.89A 3asoN-2q7sA:
undetectable
3asoW-2q7sA:
undetectable		 3asoN-2q7sA:
19.19
3asoW-2q7sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 ILE A 175
PHE A 177
ARG A 165
LEU A 130
 None
 0.85A 3asoN-2qbyA:
undetectable
3asoW-2qbyA:
undetectable		 3asoN-2qbyA:
20.30
3asoW-2qbyA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjw UNCHARACTERIZED
PROTEIN XCC1541

(Xanthomonas
campestris) 		no annotation 4 ILE A 121
LEU A  99
THR A 106
LEU A 114
 None
 0.91A 3asoN-2qjwA:
undetectable
3asoW-2qjwA:
undetectable		 3asoN-2qjwA:
16.20
3asoW-2qjwA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ILE A 272
PHE A 203
THR A  16
LEU A  17
 None
 0.87A 3asoN-2qk4A:
undetectable
3asoW-2qk4A:
undetectable		 3asoN-2qk4A:
22.52
3asoW-2qk4A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 ILE A 566
PHE A 563
ARG A 572
LEU A 492
 None
 0.92A 3asoN-2qqoA:
undetectable
3asoW-2qqoA:
undetectable		 3asoN-2qqoA:
20.44
3asoW-2qqoA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 PHE A 347
MET A 334
THR A 335
LEU A 336
 None
 0.89A 3asoN-2uvfA:
undetectable
3asoW-2uvfA:
undetectable		 3asoN-2uvfA:
22.56
3asoW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqw INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 ILE A 179
LEU A 193
ARG A 184
THR A 186
LEU A 207
 None
 1.40A 3asoN-2wqwA:
undetectable
3asoW-2wqwA:
undetectable		 3asoN-2wqwA:
18.02
3asoW-2wqwA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 4 LEU 1  84
PHE 1 156
THR 1 198
LEU 1 197
 None
 0.89A 3asoN-2ws91:
undetectable
3asoW-2ws91:
undetectable		 3asoN-2ws91:
19.07
3asoW-2ws91:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		4 LEU C 309
ARG C 345
THR C 423
LEU C 424
 None
 0.72A 3asoN-2wy0C:
undetectable
3asoW-2wy0C:
undetectable		 3asoN-2wy0C:
21.21
3asoW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE

(Aeromonas
salmonicida) 		PF14521
(Aspzincin_M35) 		4 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.81A 3asoN-2x3cA:
undetectable
3asoW-2x3cA:
undetectable		 3asoN-2x3cA:
20.64
3asoW-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		4 ILE A 301
LEU A 304
PHE A 305
LEU A 373
 None
 0.91A 3asoN-2xutA:
1.4
3asoW-2xutA:
undetectable		 3asoN-2xutA:
23.16
3asoW-2xutA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		5 LEU A 244
PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.08A 3asoN-2xxlA:
undetectable
3asoW-2xxlA:
undetectable		 3asoN-2xxlA:
19.17
3asoW-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 ILE A  75
LEU A  77
THR A  60
LEU A  59
 None
 0.73A 3asoN-2y24A:
undetectable
3asoW-2y24A:
undetectable		 3asoN-2y24A:
22.63
3asoW-2y24A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		5 TYR J  32
ARG J  33
MET J  36
THR J  37
LEU J  40
 None
 0.51A 3asoN-2y69J:
undetectable
3asoW-2y69J:
7.9		 3asoN-2y69J:
10.31
3asoW-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ILE A 617
PHE A 646
THR A 606
LEU A 635
 None
 0.83A 3asoN-2yheA:
undetectable
3asoW-2yheA:
undetectable		 3asoN-2yheA:
20.41
3asoW-2yheA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A 193
LEU A  97
PHE A 196
MET A 184
 None
 0.77A 3asoN-2ze0A:
undetectable
3asoW-2ze0A:
undetectable		 3asoN-2ze0A:
19.59
3asoW-2ze0A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgk ANTI-TUMOR LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.92A 3asoN-2zgkA:
undetectable
3asoW-2zgkA:
undetectable		 3asoN-2zgkA:
15.56
3asoW-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		4 TYR A 471
MET A 475
THR A 476
LEU A 479
 None
 0.79A 3asoN-2ziuA:
undetectable
3asoW-2ziuA:
undetectable		 3asoN-2ziuA:
18.55
3asoW-2ziuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.69A 3asoN-2ztsA:
undetectable
3asoW-2ztsA:
undetectable		 3asoN-2ztsA:
17.81
3asoW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adc L-SERYL-TRNA(SEC)
KINASE

(Methanocaldococcus
jannaschii) 		PF08433
(KTI12) 		4 ILE A 159
LEU A  20
PHE A 156
LEU A 102
 None
 0.91A 3asoN-3adcA:
2.9
3asoW-3adcA:
undetectable		 3asoN-3adcA:
16.54
3asoW-3adcA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 352
LEU A 377
THR A 348
LEU A 372
 None
 0.81A 3asoN-3b2dA:
undetectable
3asoW-3b2dA:
undetectable		 3asoN-3b2dA:
20.65
3asoW-3b2dA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 ILE A 343
LEU A 347
PHE A 344
LEU A 396
 None
 0.84A 3asoN-3b46A:
undetectable
3asoW-3b46A:
undetectable		 3asoN-3b46A:
22.55
3asoW-3b46A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 ILE A  66
ARG A 100
THR A  42
LEU A  43
 None
 0.85A 3asoN-3b4uA:
undetectable
3asoW-3b4uA:
undetectable		 3asoN-3b4uA:
20.99
3asoW-3b4uA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b57 LIN1889 PROTEIN

(Listeria
innocua) 		PF01966
(HD) 		4 ILE A  30
PHE A  18
THR A  73
LEU A  76
 None
 0.92A 3asoN-3b57A:
undetectable
3asoW-3b57A:
undetectable		 3asoN-3b57A:
16.01
3asoW-3b57A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.35A 3asoN-3b7yA:
undetectable
3asoW-3b7yA:
undetectable		 3asoN-3b7yA:
13.39
3asoW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
LEU A  62
ARG A  73
LEU A 200
 None
 0.80A 3asoN-3c9bA:
undetectable
3asoW-3c9bA:
undetectable		 3asoN-3c9bA:
16.41
3asoW-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 LEU A  53
PHE A  50
ARG A  77
LEU A 115
 None
 0.80A 3asoN-3dbyA:
1.9
3asoW-3dbyA:
undetectable		 3asoN-3dbyA:
17.09
3asoW-3dbyA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 LEU A  30
PHE A  32
TYR A 255
THR A 271
 None
 0.78A 3asoN-3dcpA:
undetectable
3asoW-3dcpA:
undetectable		 3asoN-3dcpA:
19.37
3asoW-3dcpA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		4 ILE A 105
LEU A 120
THR A  97
LEU A  96
 None
 0.91A 3asoN-3dkaA:
undetectable
3asoW-3dkaA:
undetectable		 3asoN-3dkaA:
13.42
3asoW-3dkaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0s UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF05235
(CHAD) 		4 PHE A 255
TYR A 347
MET A 351
THR A 352
 None
 0.92A 3asoN-3e0sA:
undetectable
3asoW-3e0sA:
undetectable		 3asoN-3e0sA:
19.13
3asoW-3e0sA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 ILE A 230
LEU A 231
THR A 219
LEU A 255
 None
 0.83A 3asoN-3e7fA:
undetectable
3asoW-3e7fA:
undetectable		 3asoN-3e7fA:
19.65
3asoW-3e7fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 5 ILE A 784
PHE A 747
ARG A 721
MET A 720
LEU A 718
 None
 1.44A 3asoN-3f95A:
undetectable
3asoW-3f95A:
undetectable		 3asoN-3f95A:
17.88
3asoW-3f95A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		4 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.87A 3asoN-3fddA:
undetectable
3asoW-3fddA:
undetectable		 3asoN-3fddA:
21.01
3asoW-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.81A 3asoN-3fg4A:
undetectable
3asoW-3fg4A:
undetectable		 3asoN-3fg4A:
20.56
3asoW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ILE A 200
MET A 158
THR A 159
LEU A 160
 None
 0.91A 3asoN-3fssA:
undetectable
3asoW-3fssA:
undetectable		 3asoN-3fssA:
19.04
3asoW-3fssA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 ILE A 131
MET A 159
THR A 160
LEU A 163
 None
 0.88A 3asoN-3gjuA:
undetectable
3asoW-3gjuA:
undetectable		 3asoN-3gjuA:
22.26
3asoW-3gjuA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 165
LEU B  48
ARG B  31
LEU B  36
 None
 0.79A 3asoN-3gzyB:
undetectable
3asoW-3gzyB:
undetectable		 3asoN-3gzyB:
15.34
3asoW-3gzyB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 ILE A 147
LEU A 152
THR A 331
LEU A 332
 None
 0.75A 3asoN-3h5tA:
undetectable
3asoW-3h5tA:
undetectable		 3asoN-3h5tA:
21.02
3asoW-3h5tA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7a SHORT CHAIN
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00106
(adh_short) 		4 ILE A 135
PHE A 137
THR A  70
LEU A  73
 ILE  A 135 ( 0.6A)
PHE  A 137 ( 1.3A)
THR  A  70 ( 0.8A)
LEU  A  73 ( 0.5A)
 0.92A 3asoN-3h7aA:
1.0
3asoW-3h7aA:
undetectable		 3asoN-3h7aA:
18.89
3asoW-3h7aA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		4 ILE A  95
PHE A  81
THR A 109
LEU A 108
 None
 0.89A 3asoN-3h7nA:
2.7
3asoW-3h7nA:
undetectable		 3asoN-3h7nA:
21.45
3asoW-3h7nA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A  15
ARG A  37
THR A  50
LEU A  51
 None
 0.86A 3asoN-3hi8A:
undetectable
3asoW-3hi8A:
undetectable		 3asoN-3hi8A:
20.53
3asoW-3hi8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn5 PUTATIVE EXPORTED
PROTEIN BF0290

(Bacteroides
fragilis) 		PF12866
(DUF3823) 		4 ILE A 105
ARG A  36
THR A  34
LEU A  33
 None
 0.76A 3asoN-3hn5A:
undetectable
3asoW-3hn5A:
undetectable		 3asoN-3hn5A:
17.12
3asoW-3hn5A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2m ORF59

(Human
gammaherpesvirus
8) 		PF04929
(Herpes_DNAp_acc) 		5 LEU X  98
PHE X  99
ARG X  61
THR X  45
LEU X  66
 None
 1.42A 3asoN-3i2mX:
undetectable
3asoW-3i2mX:
undetectable		 3asoN-3i2mX:
20.62
3asoW-3i2mX:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		4 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.92A 3asoN-3iqdB:
undetectable
3asoW-3iqdB:
undetectable		 3asoN-3iqdB:
21.05
3asoW-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		5 ILE A  66
LEU A  37
PHE A  68
THR A 262
LEU A 260
 None
 1.02A 3asoN-3ix1A:
undetectable
3asoW-3ix1A:
undetectable		 3asoN-3ix1A:
19.80
3asoW-3ix1A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 ILE A 374
LEU A 249
ARG A 245
LEU A 317
 None
 0.82A 3asoN-3j4pA:
undetectable
3asoW-3j4pA:
undetectable		 3asoN-3j4pA:
22.36
3asoW-3j4pA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 ILE A  38
LEU A 130
PHE A 131
LEU A 183
 None
 0.92A 3asoN-3j4uA:
undetectable
3asoW-3j4uA:
undetectable		 3asoN-3j4uA:
21.07
3asoW-3j4uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		4 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.87A 3asoN-3jzdA:
undetectable
3asoW-3jzdA:
undetectable		 3asoN-3jzdA:
22.15
3asoW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ARG A 407
MET A 410
THR A 411
LEU A 414
 None
 0.66A 3asoN-3k13A:
undetectable
3asoW-3k13A:
undetectable		 3asoN-3k13A:
20.20
3asoW-3k13A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.84A 3asoN-3k1rA:
undetectable
3asoW-3k1rA:
undetectable		 3asoN-3k1rA:
14.45
3asoW-3k1rA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.84A 3asoN-3kuqA:
undetectable
3asoW-3kuqA:
undetectable		 3asoN-3kuqA:
17.51
3asoW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyj CHEY6 PROTEIN

(Rhodobacter
sphaeroides) 		PF00072
(Response_reg) 		4 ILE B   7
MET B 128
THR B 127
LEU B 124
 None
 0.89A 3asoN-3kyjB:
undetectable
3asoW-3kyjB:
undetectable		 3asoN-3kyjB:
15.09
3asoW-3kyjB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		5 ILE A 180
LEU A 192
PHE A 194
ARG A 201
LEU A 207
 None
 1.32A 3asoN-3kzxA:
undetectable
3asoW-3kzxA:
undetectable		 3asoN-3kzxA:
17.44
3asoW-3kzxA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2n PEPTIDASE M14,
CARBOXYPEPTIDASE A

(Shewanella
denitrificans) 		PF00246
(Peptidase_M14) 		4 ILE A 104
LEU A  99
ARG A  83
THR A  86
 None
 0.92A 3asoN-3l2nA:
undetectable
3asoW-3l2nA:
undetectable		 3asoN-3l2nA:
21.32
3asoW-3l2nA:
9.44