SIMILAR PATTERNS OF AMINO ACIDS FOR 3ASN_P_CHDP1271_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3q PROTEIN (NUCLEAR
FACTOR KAPPA-B P52)

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 LYS A 310
LEU A 309
LEU A 248
PHE A 289
 None
 0.99A 3asnP-1a3qA:
undetectable
3asnW-1a3qA:
undetectable		 3asnP-1a3qA:
21.92
3asnW-1a3qA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  31
LEU A  41
PHE A  19
LEU A  24
 None
 0.99A 3asnP-1bucA:
3.5
3asnW-1bucA:
0.0		 3asnP-1bucA:
17.69
3asnW-1bucA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 LEU A  58
PHE A 324
LEU A 320
PHE A  86
 None
 1.05A 3asnP-1c4oA:
undetectable
3asnW-1c4oA:
0.0		 3asnP-1c4oA:
16.59
3asnW-1c4oA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 164
PHE A 175
LEU A 179
PHE A 183
 None
 0.65A 3asnP-1dj3A:
undetectable
3asnW-1dj3A:
undetectable		 3asnP-1dj3A:
19.00
3asnW-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Salmonella
enterica) 		PF00797
(Acetyltransf_2) 		4 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.04A 3asnP-1e2tA:
undetectable
3asnW-1e2tA:
0.0		 3asnP-1e2tA:
23.15
3asnW-1e2tA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fqt RIESKE-TYPE
FERREDOXIN OF
BIPHENYL DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00355
(Rieske) 		4 LYS A  87
LEU A  86
PHE A  70
LEU A  50
 None
 0.92A 3asnP-1fqtA:
undetectable
3asnW-1fqtA:
0.0		 3asnP-1fqtA:
15.48
3asnW-1fqtA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fym HEAT SHOCK
TRANSCRIPTION
PROTEIN

(Kluyveromyces
lactis) 		PF00447
(HSF_DNA-bind) 		4 LEU A 201
PHE A 197
LEU A 252
PHE A 278
 None
 1.00A 3asnP-1fymA:
undetectable
3asnW-1fymA:
undetectable		 3asnP-1fymA:
13.90
3asnW-1fymA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
 None
 0.88A 3asnP-1jkwA:
undetectable
3asnW-1jkwA:
0.0		 3asnP-1jkwA:
20.52
3asnW-1jkwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.94A 3asnP-1js6A:
undetectable
3asnW-1js6A:
0.0		 3asnP-1js6A:
19.84
3asnW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.84A 3asnP-1kl7A:
undetectable
3asnW-1kl7A:
undetectable		 3asnP-1kl7A:
21.24
3asnW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 1.00A 3asnP-1ny5A:
undetectable
3asnW-1ny5A:
undetectable		 3asnP-1ny5A:
19.75
3asnW-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p32 MITOCHONDRIAL MATRIX
PROTEIN, SF2P32

(Homo sapiens) 		PF02330
(MAM33) 		4 LEU A  86
PHE A  82
LEU A 275
PHE A 271
 None
 1.02A 3asnP-1p32A:
undetectable
3asnW-1p32A:
undetectable		 3asnP-1p32A:
20.22
3asnW-1p32A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A 130
PHE A 161
PHE A 115
LEU A  60
 None
 1.04A 3asnP-1rrhA:
0.4
3asnW-1rrhA:
undetectable		 3asnP-1rrhA:
15.87
3asnW-1rrhA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sk7 HYPOTHETICAL PROTEIN
PA-HO

(Pseudomonas
aeruginosa) 		PF01126
(Heme_oxygenase) 		4 LYS A  34
PHE A 197
LEU A 193
PHE A 189
 None
None
None
HEM  A 300 (-3.7A)
 0.98A 3asnP-1sk7A:
2.1
3asnW-1sk7A:
undetectable		 3asnP-1sk7A:
21.29
3asnW-1sk7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.85A 3asnP-1u8vA:
3.9
3asnW-1u8vA:
undetectable		 3asnP-1u8vA:
19.70
3asnW-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 152
LEU A 153
PHE A 156
LEU A 125
 None
 1.04A 3asnP-1ua2A:
2.6
3asnW-1ua2A:
undetectable		 3asnP-1ua2A:
20.17
3asnW-1ua2A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vku ACYL CARRIER PROTEIN

(Thermotoga
maritima) 		PF00550
(PP-binding) 		4 LEU A  70
PHE A  48
LEU A  44
PHE A  36
 None
 0.83A 3asnP-1vkuA:
undetectable
3asnW-1vkuA:
undetectable		 3asnP-1vkuA:
13.64
3asnW-1vkuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrj METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01035
(DNA_binding_1) 		4 LEU A  60
PHE A  45
LEU A  49
PHE A  53
 None
 1.01A 3asnP-1wrjA:
undetectable
3asnW-1wrjA:
undetectable		 3asnP-1wrjA:
16.60
3asnW-1wrjA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haj DNA PRIMASE

(Escherichia
coli) 		PF08278
(DnaG_DnaB_bind) 		4 LEU A 454
PHE A 535
LEU A 539
PHE A 543
 None
 0.78A 3asnP-2hajA:
undetectable
3asnW-2hajA:
undetectable		 3asnP-2hajA:
19.01
3asnW-2hajA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 131
PHE A 135
PHE A  74
LEU A  70
 None
 0.88A 3asnP-2ibdA:
undetectable
3asnW-2ibdA:
undetectable		 3asnP-2ibdA:
24.73
3asnW-2ibdA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A  78
PHE A  15
PHE A  18
LEU A 262
 None
 1.03A 3asnP-2nmpA:
undetectable
3asnW-2nmpA:
undetectable		 3asnP-2nmpA:
20.25
3asnW-2nmpA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.83A 3asnP-2nt8A:
2.7
3asnW-2nt8A:
undetectable		 3asnP-2nt8A:
21.30
3asnW-2nt8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
 None
 0.66A 3asnP-2optA:
3.1
3asnW-2optA:
undetectable		 3asnP-2optA:
23.19
3asnW-2optA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otn DIAMINOPIMELATE
EPIMERASE

(Bacillus
anthracis) 		PF01678
(DAP_epimerase) 		4 ARG A  81
LYS A 271
LEU A 258
LEU A  12
 None
 0.72A 3asnP-2otnA:
undetectable
3asnW-2otnA:
undetectable		 3asnP-2otnA:
21.78
3asnW-2otnA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oum 50S RIBOSOMAL
PROTEIN L1

(Thermus
thermophilus) 		PF00687
(Ribosomal_L1) 		4 LEU A  47
PHE A 208
LEU A 196
PHE A 163
 None
 1.04A 3asnP-2oumA:
undetectable
3asnW-2oumA:
undetectable		 3asnP-2oumA:
16.73
3asnW-2oumA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A
TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		4 PHE A  99
PHE B   9
LEU B  14
PHE B  18
 None
 0.90A 3asnP-2p1nA:
undetectable
3asnW-2p1nA:
undetectable		 3asnP-2p1nA:
18.58
3asnW-2p1nA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhp FRUCTOKINASE

(Bacteroides
thetaiotaomicron) 		PF00294
(PfkB) 		4 LYS A 175
LEU A 174
PHE A 168
LEU A 202
 None
None
EDO  A 298 ( 4.9A)
EDO  A 298 (-4.9A)
 1.03A 3asnP-2qhpA:
undetectable
3asnW-2qhpA:
undetectable		 3asnP-2qhpA:
21.57
3asnW-2qhpA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		5 LYS A 335
LEU A 338
PHE A 342
PHE A 195
LEU A 194
 None
 1.29A 3asnP-2qp2A:
undetectable
3asnW-2qp2A:
undetectable		 3asnP-2qp2A:
18.59
3asnW-2qp2A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		4 LEU A 113
PHE A  93
PHE A 123
LEU A  70
 None
 0.95A 3asnP-2riuA:
undetectable
3asnW-2riuA:
undetectable		 3asnP-2riuA:
21.66
3asnW-2riuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrd HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LYS A 106
LEU A 109
PHE A 115
LEU A 176
 None
 0.94A 3asnP-2wrdA:
undetectable
3asnW-2wrdA:
undetectable		 3asnP-2wrdA:
18.97
3asnW-2wrdA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 LEU C  35
PHE C  60
PHE C  33
LEU C  87
 None
 1.03A 3asnP-2ynmC:
undetectable
3asnW-2ynmC:
undetectable		 3asnP-2ynmC:
21.92
3asnW-2ynmC:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 LEU A  44
PHE A  69
PHE A  42
LEU A  96
 None
 1.01A 3asnP-3aeuA:
undetectable
3asnW-3aeuA:
undetectable		 3asnP-3aeuA:
22.02
3asnW-3aeuA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 4 LEU A 123
PHE A 121
PHE A  45
LEU A  18
 None
 0.89A 3asnP-3ba3A:
undetectable
3asnW-3ba3A:
undetectable		 3asnP-3ba3A:
21.19
3asnW-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 LYS A  59
LEU A  62
PHE A  68
PHE A 107
 None
 0.99A 3asnP-3c9bA:
undetectable
3asnW-3c9bA:
undetectable		 3asnP-3c9bA:
17.54
3asnW-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU C  73
PHE C  75
PHE C   7
LEU C 176
 None
 1.03A 3asnP-3degC:
undetectable
3asnW-3degC:
undetectable		 3asnP-3degC:
17.43
3asnW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
LEU A 192
PHE A 196
PHE A 153
 None
 0.86A 3asnP-3g1zA:
undetectable
3asnW-3g1zA:
undetectable		 3asnP-3g1zA:
20.94
3asnW-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.82A 3asnP-3gajA:
2.8
3asnW-3gajA:
undetectable		 3asnP-3gajA:
21.16
3asnW-3gajA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrt METALLOREGULATOR
SCAR

(Streptococcus
gordonii) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		4 ARG A  74
LYS A  75
LEU A  78
PHE A  82
 None
 0.71A 3asnP-3hrtA:
undetectable
3asnW-3hrtA:
undetectable		 3asnP-3hrtA:
18.61
3asnW-3hrtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.95A 3asnP-3iv0A:
2.0
3asnW-3iv0A:
undetectable		 3asnP-3iv0A:
20.57
3asnW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 LEU A 530
PHE A 569
LEU A 566
PHE A 526
 None
 0.92A 3asnP-3j9dA:
undetectable
3asnW-3j9dA:
undetectable		 3asnP-3j9dA:
13.31
3asnW-3j9dA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		4 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.97A 3asnP-3k6xA:
undetectable
3asnW-3k6xA:
undetectable		 3asnP-3k6xA:
20.87
3asnW-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.87A 3asnP-3lcrA:
undetectable
3asnW-3lcrA:
undetectable		 3asnP-3lcrA:
20.45
3asnW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 LEU A 204
PHE A 208
LEU A 187
PHE A 195
 None
None
None
EDO  A 231 (-3.8A)
 1.00A 3asnP-3mvuA:
3.0
3asnW-3mvuA:
undetectable		 3asnP-3mvuA:
20.30
3asnW-3mvuA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 483
PHE A 465
LEU A 461
PHE A 456
 None
None
None
IBM  A   1 (-3.4A)
 1.00A 3asnP-3n3zA:
3.3
3asnW-3n3zA:
undetectable		 3asnP-3n3zA:
21.17
3asnW-3n3zA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PHE A 327
PHE A 299
LEU A 296
PHE A 294
 None
 0.96A 3asnP-3ogrA:
undetectable
3asnW-3ogrA:
undetectable		 3asnP-3ogrA:
14.48
3asnW-3ogrA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 LEU A 214
PHE A 152
PHE A 173
LEU A 201
 None
 0.93A 3asnP-3oqqA:
undetectable
3asnW-3oqqA:
undetectable		 3asnP-3oqqA:
20.13
3asnW-3oqqA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 ARG A 131
LEU A 191
PHE A 246
LEU A 241
 None
 1.01A 3asnP-3rd5A:
undetectable
3asnW-3rd5A:
undetectable		 3asnP-3rd5A:
21.79
3asnW-3rd5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4y PROTEIN MXIG

(Shigella
flexneri) 		PF09480
(PrgH) 		4 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.69A 3asnP-4a4yA:
undetectable
3asnW-4a4yA:
undetectable		 3asnP-4a4yA:
19.17
3asnW-4a4yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4abn TETRATRICOPEPTIDE
REPEAT PROTEIN 5

(Mus musculus) 		PF16669
(TTC5_OB) 		4 LYS A 281
PHE A 355
LEU A 274
PHE A 405
 None
 0.96A 3asnP-4abnA:
3.2
3asnW-4abnA:
undetectable		 3asnP-4abnA:
19.53
3asnW-4abnA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.71A 3asnP-4c8qH:
undetectable
3asnW-4c8qH:
undetectable		 3asnP-4c8qH:
19.40
3asnW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1

(Mytilus
galloprovincialis) 		PF00092
(VWA) 		4 LYS A 234
LEU A 233
PHE A  79
LEU A  83
 None
 0.98A 3asnP-4cn8A:
undetectable
3asnW-4cn8A:
undetectable		 3asnP-4cn8A:
20.00
3asnW-4cn8A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		4 LEU A 215
PHE A 210
LEU A 155
PHE A 222
 None
 1.04A 3asnP-4e1eA:
2.8
3asnW-4e1eA:
undetectable		 3asnP-4e1eA:
20.44
3asnW-4e1eA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 321
PHE A  23
PHE A  25
LEU A 376
 None
 0.96A 3asnP-4e5tA:
undetectable
3asnW-4e5tA:
undetectable		 3asnP-4e5tA:
21.58
3asnW-4e5tA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.91A 3asnP-4flxA:
2.4
3asnW-4flxA:
undetectable		 3asnP-4flxA:
13.49
3asnW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9b BETA-PHOSPHOGLUCOMUT
ASE

(Escherichia
coli) 		PF13419
(HAD_2) 		4 LEU A 114
PHE A   8
PHE A 134
LEU A 125
 None
 1.05A 3asnP-4g9bA:
undetectable
3asnW-4g9bA:
undetectable		 3asnP-4g9bA:
21.31
3asnW-4g9bA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP

(Plasmodium
falciparum) 		PF00092
(VWA) 		5 ARG A 176
LYS A 173
LEU A 172
PHE A 198
LEU A 202
 None
 1.14A 3asnP-4hqfA:
undetectable
3asnW-4hqfA:
undetectable		 3asnP-4hqfA:
20.74
3asnW-4hqfA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Sus scrofa) 		PF00271
(Helicase_C) 		4 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.57A 3asnP-4i1sA:
2.3
3asnW-4i1sA:
undetectable		 3asnP-4i1sA:
19.63
3asnW-4i1sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 228
PHE A 230
LEU A 203
PHE A 199
 None
 0.98A 3asnP-4j0mA:
undetectable
3asnW-4j0mA:
undetectable		 3asnP-4j0mA:
16.01
3asnW-4j0mA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		no annotation 4 LEU C 121
PHE C 261
LEU C 252
PHE C 248
 None
 1.02A 3asnP-4kd5C:
undetectable
3asnW-4kd5C:
undetectable		 3asnP-4kd5C:
19.08
3asnW-4kd5C:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4u TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.95A 3asnP-4l4uA:
undetectable
3asnW-4l4uA:
undetectable		 3asnP-4l4uA:
18.32
3asnW-4l4uA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 LYS A 376
LEU A 375
PHE A 291
PHE A 497
 None
 0.83A 3asnP-4lglA:
undetectable
3asnW-4lglA:
undetectable		 3asnP-4lglA:
13.79
3asnW-4lglA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 245
PHE A 269
LEU A 273
PHE A 277
 None
 1.06A 3asnP-4n5cA:
undetectable
3asnW-4n5cA:
undetectable		 3asnP-4n5cA:
14.04
3asnW-4n5cA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6q VOSA

(Aspergillus
nidulans) 		PF11754
(Velvet) 		4 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.87A 3asnP-4n6qA:
undetectable
3asnW-4n6qA:
undetectable		 3asnP-4n6qA:
22.18
3asnW-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN

(Legionella
pneumophila) 		PF13855
(LRR_8) 		5 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
 None
 1.44A 3asnP-4q62A:
undetectable
3asnW-4q62A:
undetectable		 3asnP-4q62A:
18.18
3asnW-4q62A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 4 LEU B  75
PHE B  83
LEU B  87
PHE B  91
 None
 0.72A 3asnP-4r0mB:
undetectable
3asnW-4r0mB:
undetectable		 3asnP-4r0mB:
17.42
3asnW-4r0mB:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans) 		PF09659
(Cas_Csm6) 		4 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 0.99A 3asnP-4rgpA:
undetectable
3asnW-4rgpA:
undetectable		 3asnP-4rgpA:
20.82
3asnW-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 213
PHE A 345
LEU A 353
PHE A 261
 None
 1.03A 3asnP-4rjkA:
undetectable
3asnW-4rjkA:
undetectable		 3asnP-4rjkA:
18.58
3asnW-4rjkA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		4 LEU A  31
PHE A  29
LEU A  42
PHE A  38
 None
None
None
INS  A 401 (-4.5A)
 0.92A 3asnP-4rxmA:
undetectable
3asnW-4rxmA:
undetectable		 3asnP-4rxmA:
20.81
3asnW-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud4 POLY(A) RNA
POLYMERASE PROTEIN
CID1

(Schizosaccharomyces
pombe) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		4 LYS A 144
LEU A 145
LEU A 125
PHE A 121
 None
 0.93A 3asnP-4ud4A:
undetectable
3asnW-4ud4A:
undetectable		 3asnP-4ud4A:
19.95
3asnW-4ud4A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wn9 NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 LYS A 331
LEU A 334
LEU A 503
PHE A 499
 None
None
XE  A 604 ( 4.2A)
XE  A 604 (-3.8A)
 0.65A 3asnP-4wn9A:
undetectable
3asnW-4wn9A:
undetectable		 3asnP-4wn9A:
17.15
3asnW-4wn9A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 ARG A  27
PHE A  50
PHE A  35
LEU A  34
 None
 1.01A 3asnP-4wpxA:
undetectable
3asnW-4wpxA:
undetectable		 3asnP-4wpxA:
21.84
3asnW-4wpxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		4 LYS B 253
LEU B 254
PHE B 317
PHE B 309
 None
 0.90A 3asnP-5a7vB:
undetectable
3asnW-5a7vB:
undetectable		 3asnP-5a7vB:
20.78
3asnW-5a7vB:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aox SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN

(Homo sapiens) 		PF02290
(SRP14) 		4 LEU B  86
PHE B  17
LEU B  13
PHE B   9
 None
 0.83A 3asnP-5aoxB:
undetectable
3asnW-5aoxB:
undetectable		 3asnP-5aoxB:
17.86
3asnW-5aoxB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 ARG A  80
LEU A  70
PHE A 111
PHE A  42
 None
 0.98A 3asnP-5ckmA:
undetectable
3asnW-5ckmA:
undetectable		 3asnP-5ckmA:
22.33
3asnW-5ckmA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82
NUCLEOPORIN NUP159

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation 		4 ARG C1447
LYS C1448
LEU C1451
LEU B 425
 None
 0.86A 3asnP-5cwwC:
undetectable
3asnW-5cwwC:
undetectable		 3asnP-5cwwC:
8.89
3asnW-5cwwC:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 LYS A  57
LEU A  58
PHE A  60
LEU A 182
 LYS  A  57 ( 0.0A)
LEU  A  58 ( 0.6A)
PHE  A  60 ( 1.3A)
LEU  A 182 ( 0.6A)
 0.99A 3asnP-5d7wA:
undetectable
3asnW-5d7wA:
undetectable		 3asnP-5d7wA:
19.92
3asnW-5d7wA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		4 LEU A 551
PHE A 553
LEU A 414
PHE A 410
 None
 1.03A 3asnP-5ddbA:
1.9
3asnW-5ddbA:
undetectable		 3asnP-5ddbA:
17.43
3asnW-5ddbA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 LEU A 246
PHE A 270
LEU A 242
PHE A 107
 None
 1.01A 3asnP-5e5uA:
undetectable
3asnW-5e5uA:
undetectable		 3asnP-5e5uA:
19.59
3asnW-5e5uA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 0.99A 3asnP-5eytA:
4.6
3asnW-5eytA:
undetectable		 3asnP-5eytA:
18.88
3asnW-5eytA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		4 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.98A 3asnP-5fn3B:
2.1
3asnW-5fn3B:
undetectable		 3asnP-5fn3B:
20.04
3asnW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3y ADENYLATE KINSE

(synthetic
construct) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 LYS A  69
LEU A  72
PHE A  81
LEU A  83
 None
 0.85A 3asnP-5g3yA:
undetectable
3asnW-5g3yA:
undetectable		 3asnP-5g3yA:
19.19
3asnW-5g3yA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 ARG A 293
LEU A 295
PHE A 173
LEU A 177
 None
 1.04A 3asnP-5i2hA:
undetectable
3asnW-5i2hA:
undetectable		 3asnP-5i2hA:
22.46
3asnW-5i2hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		4 LEU A  87
PHE A 204
LEU A 208
PHE A 212
 None
 0.81A 3asnP-5ipxA:
undetectable
3asnW-5ipxA:
undetectable		 3asnP-5ipxA:
20.47
3asnW-5ipxA:
11.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		6 ARG C 156
LYS C 157
LEU C 160
PHE C 164
PHE C 219
LEU C 223
 CHD  C 307 (-4.0A)
None
CHD  C 307 ( 3.9A)
CHD  C 307 (-3.9A)
None
None
 0.34A 3asnP-5iy5C:
37.4
3asnW-5iy5C:
undetectable		 3asnP-5iy5C:
100.00
3asnW-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 385
PHE A 434
LEU A 432
PHE A 360
 None
 0.84A 3asnP-5jbgA:
2.0
3asnW-5jbgA:
undetectable		 3asnP-5jbgA:
15.81
3asnW-5jbgA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlt MIDDLE TRANSCRIPTION
REGULATORY PROTEIN
MOTA

(Escherichia
virus T4) 		PF09158
(MotCF) 		4 LYS A 130
LEU A 128
LEU A 121
PHE A 152
 None
 1.03A 3asnP-5jltA:
undetectable
3asnW-5jltA:
undetectable		 3asnP-5jltA:
16.67
3asnW-5jltA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A  82
LEU A  83
PHE A  50
LEU A  54
 None
 0.89A 3asnP-5ju6A:
undetectable
3asnW-5ju6A:
undetectable		 3asnP-5ju6A:
13.89
3asnW-5ju6A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llq METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF01035
(DNA_binding_1) 		4 LEU A  60
PHE A  45
LEU A  49
PHE A  53
 None
 0.95A 3asnP-5llqA:
undetectable
3asnW-5llqA:
undetectable		 3asnP-5llqA:
19.92
3asnW-5llqA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1

(Homo sapiens;
Homo sapiens) 		PF05859
(Mis12)
PF03980
(Nnf1) 		4 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.87A 3asnP-5lskA:
undetectable
3asnW-5lskA:
2.7		 3asnP-5lskA:
21.82
3asnW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 ARG A  78
LEU A  79
PHE A  46
LEU A  50
 None
 0.97A 3asnP-5nbsA:
undetectable
3asnW-5nbsA:
undetectable		 3asnP-5nbsA:
undetectable
3asnW-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvr TELOMERE LENGTH
REGULATOR PROTEIN
RIF1

(Saccharomyces
cerevisiae) 		PF12231
(Rif1_N) 		4 LYS A1159
LEU A1162
PHE A1166
LEU A1227
 None
 1.00A 3asnP-5nvrA:
undetectable
3asnW-5nvrA:
undetectable		 3asnP-5nvrA:
12.42
3asnW-5nvrA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 4 PHE A 339
PHE A 322
LEU A 326
PHE A 330
 None
 0.88A 3asnP-5oenA:
undetectable
3asnW-5oenA:
undetectable		 3asnP-5oenA:
undetectable
3asnW-5oenA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 LYS A 167
LEU A 170
LEU A 130
PHE A 155
 None
 0.85A 3asnP-5u47A:
undetectable
3asnW-5u47A:
undetectable		 3asnP-5u47A:
13.82
3asnW-5u47A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861

(Pseudomonas
aeruginosa) 		no annotation 4 LYS A 699
PHE A 665
LEU A 661
PHE A 657
 None
 0.81A 3asnP-5xgeA:
undetectable
3asnW-5xgeA:
undetectable		 3asnP-5xgeA:
undetectable
3asnW-5xgeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 LEU A 348
PHE A 344
PHE A 380
LEU A 376
 None
 0.80A 3asnP-5xjjA:
undetectable
3asnW-5xjjA:
undetectable		 3asnP-5xjjA:
22.22
3asnW-5xjjA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 LYS A 437
LEU A 440
PHE A 388
LEU A 392
 None
 0.67A 3asnP-6bpcA:
6.9
3asnW-6bpcA:
undetectable		 3asnP-6bpcA:
undetectable
3asnW-6bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1
DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT OST5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 LEU 5  73
PHE 5  28
PHE 5  77
PHE 1 447
 None
 0.95A 3asnP-6c265:
3.2
3asnW-6c265:
undetectable		 3asnP-6c265:
undetectable
3asnW-6c265:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 4 LEU A 271
PHE A 274
PHE A  22
LEU A 336
 None
 0.93A 3asnP-6cc4A:
6.5
3asnW-6cc4A:
undetectable		 3asnP-6cc4A:
undetectable
3asnW-6cc4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 LYS E 437
LEU E 440
PHE E 388
LEU E 392
 None
 0.76A 3asnP-6d04E:
5.2
3asnW-6d04E:
1.1		 3asnP-6d04E:
undetectable
3asnW-6d04E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Eremothecium
gossypii) 		no annotation 4 ARG B  36
LEU B  38
PHE B  39
PHE B 158
 None
 1.04A 3asnP-6dexB:
undetectable
3asnW-6dexB:
undetectable		 3asnP-6dexB:
undetectable
3asnW-6dexB:
undetectable