SIMILAR PATTERNS OF AMINO ACIDS FOR 3ARU_A_PNXA606_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)

(Amycolatopsis
mediterranei) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLY A 137
ASP A 282
TRP A 168
ARG A 284
 None
 1.08A 3aruA-1b9hA:
undetectable		 3aruA-1b9hA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		4 GLY A1188
LYS A1307
ASP A1191
ARG A1288
 None
 1.04A 3aruA-1c0iA:
undetectable		 3aruA-1c0iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 GLY A 552
LYS A 553
ASP A 610
TYR A 604
 None
 1.28A 3aruA-1cygA:
9.2		 3aruA-1cygA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis) 		PF00704
(Glyco_hydro_18) 		4 GLY A 215
ASP A 240
TRP A 245
ARG A 295
 None
 0.56A 3aruA-1d2kA:
40.7		 3aruA-1d2kA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1k ADRENODOXIN
REDUCTASE

(Bos taurus) 		PF07992
(Pyr_redox_2) 		4 GLY A 330
ASP A 106
TYR A 331
ARG A 334
 NAP  A 802 ( 3.8A)
None
NAP  A 802 (-4.8A)
None
 1.04A 3aruA-1e1kA:
undetectable		 3aruA-1e1kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 GLY A 188
ASP A 215
TRP A 220
ARG A 294
 NAG  A 504 ( 4.9A)
NGO  A 502 ( 3.1A)
NAG  A 504 (-3.6A)
NAG  A 503 ( 4.9A)
 0.64A 3aruA-1e6zA:
33.5		 3aruA-1e6zA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee2 ALCOHOL
DEHYDROGENASE

(Equus caballus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 PHE A  21
GLY A  66
ASP A  50
ARG A  47
 None
None
None
NAD  A1100 (-3.7A)
 1.23A 3aruA-1ee2A:
undetectable		 3aruA-1ee2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eif EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A

(Methanocaldococcus
jannaschii) 		PF01287
(eIF-5a)
PF08207
(EFP_N) 		4 GLY A   6
LYS A   4
ASP A  75
ARG A  77
 None
 0.96A 3aruA-1eifA:
undetectable		 3aruA-1eifA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 GLY A 187
ASP A 213
TRP A 218
ARG A 269
 AMI  A1391 (-3.3A)
AMI  A1388 ( 2.9A)
NAA  A1390 (-3.2A)
NAA  A1389 (-3.2A)
 0.34A 3aruA-1hkkA:
42.1		 3aruA-1hkkA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 GLY A 440
ASP A 437
TYR A 491
ARG A 492
 None
 1.14A 3aruA-1hp1A:
undetectable		 3aruA-1hp1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx6 MAJOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF09018
(Phage_Capsid_P3) 		4 GLY A 339
ASP A 335
TYR A 341
ARG A 329
 None
 1.01A 3aruA-1hx6A:
undetectable		 3aruA-1hx6A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx6 MAJOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF09018
(Phage_Capsid_P3) 		4 PHE A  90
GLY A 339
ASP A 292
ARG A 372
 None
 1.12A 3aruA-1hx6A:
undetectable		 3aruA-1hx6A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 PHE A 233
GLY A 237
ASP A 286
ARG A 263
 None
 0.99A 3aruA-1iirA:
undetectable		 3aruA-1iirA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		4 GLY A 253
ASP A 280
TRP A 285
ARG A 340
 GOL  A1008 (-3.5A)
None
None
None
 1.00A 3aruA-1itxA:
44.9		 3aruA-1itxA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 GLY A 385
LYS A 388
TYR A 350
ARG A 348
 None
 0.89A 3aruA-1kl7A:
undetectable		 3aruA-1kl7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1klx CYSTEINE RICH
PROTEIN B

(Helicobacter
pylori) 		PF08238
(Sel1) 		4 PHE A  62
GLY A  64
ASP A  92
TYR A  84
 None
 1.24A 3aruA-1klxA:
undetectable		 3aruA-1klxA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 GLY A 177
ASP A 115
TRP A 119
ARG A 118
 None
 1.27A 3aruA-1nhcA:
undetectable		 3aruA-1nhcA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01798
(Nop) 		4 GLY B  53
ASP B  60
TYR B  61
ARG B  63
 None
 1.15A 3aruA-1nt2B:
undetectable		 3aruA-1nt2B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn3 GLYCOSYLTRANSFERASE
GTFA

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 PHE A 216
GLY A 220
ASP A 271
ARG A 248
 None
 1.14A 3aruA-1pn3A:
undetectable		 3aruA-1pn3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		4 PHE A1432
GLY A1173
ASP A1330
TRP A1333
 None
 1.26A 3aruA-1qhmA:
undetectable		 3aruA-1qhmA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 PHE A 273
GLY A 271
ASP A 299
ARG A 301
 None
 1.20A 3aruA-1r47A:
4.5		 3aruA-1r47A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrv GLYCOSYLTRANSFERASE
GTFD

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 PHE A 232
GLY A 236
ASP A 287
ARG A 264
 PHE  A 232 ( 1.3A)
GLY  A 236 ( 0.0A)
ASP  A 287 ( 0.5A)
ARG  A 264 ( 0.6A)
 1.02A 3aruA-1rrvA:
undetectable		 3aruA-1rrvA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		4 GLY A 178
ASP A 194
TRP A 229
ARG A 227
 None
 0.81A 3aruA-1ru4A:
undetectable		 3aruA-1ru4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 GLY A  75
ASP A  82
TYR A  29
ARG A  86
 None
 1.26A 3aruA-1ufaA:
undetectable		 3aruA-1ufaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ves NEW ANTIGEN RECEPTOR
VARIABLE DOMAIN

(Orectolobus
maculatus) 		PF07686
(V-set) 		4 GLY A 107
ASP A   4
TRP A   2
ARG A  25
 None
 1.23A 3aruA-1vesA:
6.2		 3aruA-1vesA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 GLY A 187
ASP A 213
TRP A 218
ARG A 269
 None
 0.55A 3aruA-1wb0A:
41.7		 3aruA-1wb0A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 GLY A 183
LYS A 186
ASP A 208
ARG A 263
 None
 0.64A 3aruA-1wnoA:
40.8		 3aruA-1wnoA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		4 GLY A 115
ASP A 111
TYR A 112
ARG A  96
 None
 1.22A 3aruA-1wxxA:
undetectable		 3aruA-1wxxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 335
ASP A 329
TYR A 330
ARG A 310
 None
 1.09A 3aruA-2bucA:
undetectable		 3aruA-2bucA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		4 PHE A 106
GLY A 117
ASP A  62
ARG A  66
 None
 1.07A 3aruA-2e6mA:
undetectable		 3aruA-2e6mA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr5 CYTIDINE DEAMINASE

(Mus musculus) 		PF00383
(dCMP_cyt_deam_1) 		4 GLY A  78
ASP A  81
TYR A  79
ARG A  83
 None
 1.06A 3aruA-2fr5A:
undetectable		 3aruA-2fr5A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 4 GLY A 253
LYS A 256
ASP A 243
TYR A 247
 None
None
ZN  A 601 (-2.2A)
None
 0.93A 3aruA-2hihA:
undetectable		 3aruA-2hihA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijy THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Vibrio cholerae) 		PF01323
(DSBA) 		4 PHE A   3
GLY A 161
ASP A 168
TYR A 170
 None
 1.20A 3aruA-2ijyA:
undetectable		 3aruA-2ijyA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE

(Bos taurus) 		PF03414
(Glyco_transf_6) 		4 GLY A 275
ASP A 257
TRP A 250
TYR A 260
 None
 0.96A 3aruA-2jcjA:
undetectable		 3aruA-2jcjA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		4 GLY A 157
ASP A 265
TRP A 142
ARG A 312
 None
 1.16A 3aruA-2jjfA:
2.8		 3aruA-2jjfA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Aspergillus
oryzae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 339
GLY A 355
ASP A 336
ARG A 359
 None
 1.23A 3aruA-2ps2A:
3.8		 3aruA-2ps2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 GLY A 183
ASP A 259
TRP A 254
ARG A 263
 None
 0.87A 3aruA-2q3zA:
4.5		 3aruA-2q3zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN

(Escherichia
coli) 		PF03349
(Toluene_X) 		4 GLY A  12
LYS A   9
TYR A  17
ARG A 228
 None
 0.99A 3aruA-2r8aA:
undetectable		 3aruA-2r8aA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 PHE A 205
GLY A 141
ASP A  39
TYR A 139
 None
None
None
ACT  A1558 (-4.7A)
 1.15A 3aruA-2v7gA:
2.1		 3aruA-2v7gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 GLY A 245
ASP A 263
TYR A 279
ARG A 262
 None
 1.20A 3aruA-2vmjA:
undetectable		 3aruA-2vmjA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		6 PHE A 316
GLY A 366
LYS A 369
ASP A 391
TYR A 418
ARG A 446
 None
SN5  A1567 ( 4.5A)
SN5  A1567 (-3.2A)
NGT  A1565 (-2.9A)
SN5  A1567 (-2.9A)
SN5  A1566 ( 3.5A)
 0.55A 3aruA-2wk2A:
33.2		 3aruA-2wk2A:
51.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00121
(TIM) 		4 GLY A 230
ASP A 227
TYR A 223
ARG A 226
 None
 1.15A 3aruA-2x2gA:
4.2		 3aruA-2x2gA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xst LIPOCALIN 15

(Homo sapiens) 		PF00061
(Lipocalin) 		4 GLY A 105
ASP A 108
TYR A 106
ARG A 110
 None
 1.24A 3aruA-2xstA:
undetectable		 3aruA-2xstA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 GLY A 413
ASP A 410
TYR A 474
ARG A 475
 None
 1.16A 3aruA-2z1aA:
2.2		 3aruA-2z1aA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF03480
(DctP) 		4 GLY A 151
ASP A 136
TYR A 149
ARG A 140
 None
 1.05A 3aruA-2zzwA:
undetectable		 3aruA-2zzwA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		6 PHE A 316
GLY A 367
ASP A 392
TRP A 397
TYR A 435
ARG A 463
 None
 0.49A 3aruA-3b9eA:
64.6		 3aruA-3b9eA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		6 PHE A 316
GLY A 367
LYS A 370
ASP A 392
TRP A 397
ARG A 463
 None
 0.48A 3aruA-3b9eA:
64.6		 3aruA-3b9eA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6l CHITINASE

(Clonostachys
rosea) 		PF00704
(Glyco_hydro_18) 		4 GLY A 218
ASP A 243
TRP A 248
ARG A 298
 None
 0.80A 3aruA-3g6lA:
41.4		 3aruA-3g6lA:
26.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 PHE A 216
GLY A 220
ASP A 269
ARG A 246
 None
 1.04A 3aruA-3h4iA:
undetectable		 3aruA-3h4iA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc7 GENE 12 PROTEIN

(Mycobacterium
virus D29) 		PF01083
(Cutinase) 		4 GLY A  11
ASP A  25
TYR A  81
ARG A 244
 None
 1.10A 3aruA-3hc7A:
undetectable		 3aruA-3hc7A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie4 GRAM-NEGATIVE
BINDING PROTEIN 3

(Drosophila
melanogaster) 		PF15886
(CBM39) 		4 PHE A  94
GLY A  98
ASP A   9
TYR A  99
 None
 1.26A 3aruA-3ie4A:
5.5		 3aruA-3ie4A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n7z ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 PHE A 280
GLY A  80
ASP A 388
ARG A 185
 None
 1.24A 3aruA-3n7zA:
undetectable		 3aruA-3n7zA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		4 GLY A 277
ASP A 258
TYR A 279
ARG A 256
 None
 1.18A 3aruA-3pgbA:
undetectable		 3aruA-3pgbA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcz DNA REPAIR PROTEIN
RAD60
SUMO-CONJUGATING
ENZYME UBC9

(Schizosaccharomyces
pombe) 		PF00179
(UQ_con)
PF11976
(Rad60-SLD) 		4 GLY B  44
LYS B  59
TRP A 383
TYR B  25
 None
 0.87A 3aruA-3rczB:
undetectable		 3aruA-3rczB:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjl 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Bacillus
licheniformis) 		PF00171
(Aldedh) 		4 PHE A 485
GLY A 477
ASP A 292
TYR A 470
 None
 1.08A 3aruA-3rjlA:
undetectable		 3aruA-3rjlA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		4 PHE A 250
GLY A 252
ASP A 221
ARG A 229
 None
MN  A 555 (-4.2A)
None
CL  A 800 (-3.4A)
 1.24A 3aruA-3rl3A:
undetectable		 3aruA-3rl3A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tis PROTEIN YRDA

(Escherichia
coli) 		PF00132
(Hexapep) 		4 GLY A 160
ASP A  86
TYR A 163
ARG A  57
 None
 1.20A 3aruA-3tisA:
undetectable		 3aruA-3tisA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A1349
GLY A1635
TRP A1549
ARG A1544
 BTI  A1901 (-4.6A)
URE  A1902 (-3.0A)
None
None
 1.26A 3aruA-3va7A:
undetectable		 3aruA-3va7A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		4 PHE A 476
GLY A 429
ASP A 398
TYR A 438
 None
 0.94A 3aruA-3welA:
10.5		 3aruA-3welA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		4 GLY A 445
LYS A 446
ASP A 466
ARG A 349
 None
 1.27A 3aruA-4e2iA:
undetectable		 3aruA-4e2iA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evz HISF-LUCA

(synthetic
construct) 		PF00977
(His_biosynth) 		4 PHE A 230
GLY A  20
ASP A  28
ARG A  16
 None
 0.97A 3aruA-4evzA:
9.9		 3aruA-4evzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft2 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Zea mays) 		PF00145
(DNA_methylase)
PF00385
(Chromo)
PF01426
(BAH) 		4 PHE A 703
ASP A 710
TYR A 835
ARG A 837
 None
 1.20A 3aruA-4ft2A:
undetectable		 3aruA-4ft2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLY A 194
ASP A 113
TYR A 115
ARG A 205
 None
 1.13A 3aruA-4kxbA:
undetectable		 3aruA-4kxbA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8b YHR177W

(Saccharomyces
cerevisiae) 		PF09729
(Gti1_Pac2) 		4 PHE R  78
LYS R 119
ASP R  13
TYR R  10
 None
 1.26A 3aruA-4m8bR:
undetectable		 3aruA-4m8bR:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlk CT584 PROTEIN

(Chlamydia
trachomatis) 		PF17435
(DUF5414) 		4 GLY A  31
ASP A  93
TYR A  32
ARG A  97
 None
 1.19A 3aruA-4mlkA:
undetectable		 3aruA-4mlkA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc1 A20.1 VHH

(Lama glama) 		PF07686
(V-set) 		4 GLY C 109
ASP C 115
TRP C 120
ARG C  52
 None
 1.24A 3aruA-4nc1C:
6.4		 3aruA-4nc1C:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 PHE A 908
GLY A 930
TYR A 928
ARG A 921
 None
 0.87A 3aruA-4nh0A:
undetectable		 3aruA-4nh0A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 PHE A  92
GLY A 247
ASP A  89
ARG A  86
 None
 1.27A 3aruA-4pdxA:
undetectable		 3aruA-4pdxA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 GLY A 586
ASP A 613
TYR A 588
ARG A 557
 None
 1.24A 3aruA-4pw5A:
undetectable		 3aruA-4pw5A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6g PYRROLYSINE--TRNA
LIGASE

(Methanosarcina
mazei) 		PF01409
(tRNA-synt_2d) 		4 PHE A 374
GLY A 371
ASP A 365
ARG A 257
 None
 1.23A 3aruA-4q6gA:
undetectable		 3aruA-4q6gA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 GLY A 323
ASP A 287
TYR A 285
ARG A 299
 None
 1.12A 3aruA-4qfuA:
10.7		 3aruA-4qfuA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 GLY A  20
ASP A  89
TYR A  26
ARG A  75
 None
 1.03A 3aruA-4rapA:
4.1		 3aruA-4rapA:
21.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 4 LYS B 229
ASP B 251
TRP B 256
ARG B 307
 None
MLI  B 501 ( 4.7A)
MLI  B 501 ( 4.2A)
None
 0.76A 3aruA-4w5uB:
42.9		 3aruA-4w5uB:
30.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLY A 127
ASP A 178
TYR A 125
ARG A 123
 None
 1.21A 3aruA-4wkyA:
undetectable		 3aruA-4wkyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxu MYOCILIN

(Homo sapiens) 		PF02191
(OLF) 		4 GLY A 292
ASP A 289
TRP A 489
ARG A 287
 None
 1.18A 3aruA-4wxuA:
undetectable		 3aruA-4wxuA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrn ALGINATE
BIOSYNTHESIS PROTEIN
ALG44

(Pseudomonas
aeruginosa) 		PF07238
(PilZ) 		4 GLY A  21
ASP A  28
TYR A  19
ARG A  16
 None
ZN  A 205 ( 1.9A)
None
None
 0.98A 3aruA-4xrnA:
undetectable		 3aruA-4xrnA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yly PEPTIDYL-TRNA
HYDROLASE

(Staphylococcus
aureus) 		PF01195
(Pept_tRNA_hydro) 		4 PHE A  42
LYS A  41
ASP A  77
TYR A  79
 None
 1.27A 3aruA-4ylyA:
undetectable		 3aruA-4ylyA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Yersinia pestis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 PHE A 303
GLY A 305
ASP A 182
ARG A 184
 None
SCY  A 112 ( 3.9A)
None
None
 0.95A 3aruA-4z19A:
undetectable		 3aruA-4z19A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 PHE A 790
GLY A 691
ASP A 688
TYR A 847
 None
 1.10A 3aruA-4zm6A:
2.2		 3aruA-4zm6A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 PHE A 804
GLY A 623
ASP A 799
ARG A 769
 None
 1.19A 3aruA-5bp1A:
undetectable		 3aruA-5bp1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda) 		PF00232
(Glyco_hydro_1) 		4 PHE A 182
GLY A 240
ASP A 177
ARG A 178
 None
 1.17A 3aruA-5cg0A:
11.0		 3aruA-5cg0A:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		7 PHE A 306
GLY A 357
LYS A 360
ASP A 382
TRP A 387
TYR A 409
ARG A 437
 None
None
None
58Y  A 605 ( 3.0A)
NAG  A 603 (-4.5A)
None
58Y  A 605 ( 3.3A)
 0.75A 3aruA-5df0A:
54.6		 3aruA-5df0A:
44.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e76 SUSD-LIKE PROTEIN
BACOVA_02651

(Bacteroides
ovatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PHE A 499
GLY A 502
ASP A 477
TYR A 506
 None
 1.22A 3aruA-5e76A:
undetectable		 3aruA-5e76A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 PHE A 116
GLY A  43
ASP A 601
ARG A 833
 None
FES  A3002 (-3.9A)
None
None
 1.26A 3aruA-5epgA:
undetectable		 3aruA-5epgA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A  82
ASP A  28
TYR A  32
ARG A  22
 None
 1.11A 3aruA-5gmsA:
undetectable		 3aruA-5gmsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 PHE A 203
GLY A  77
ASP A  28
TYR A  32
 None
 1.27A 3aruA-5gmsA:
undetectable		 3aruA-5gmsA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		7 PHE A 309
GLY A 359
LYS A 362
ASP A 384
TRP A 389
TYR A 411
ARG A 439
 PHE  A 309 ( 1.3A)
GLY  A 359 ( 0.0A)
LYS  A 362 ( 0.0A)
ASP  A 384 ( 0.5A)
TRP  A 389 (-0.5A)
TYR  A 411 ( 1.3A)
ARG  A 439 ( 0.6A)
 0.46A 3aruA-5gprA:
56.0		 3aruA-5gprA:
50.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 GLY B 740
ASP B 767
TRP B 772
ARG B 818
 None
 1.04A 3aruA-5gztB:
41.2		 3aruA-5gztB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 GLY A 740
ASP A 767
TRP A 772
ARG A 818
 None
 1.03A 3aruA-5gzuA:
40.6		 3aruA-5gzuA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
coronavirus
HKU1;
Human
immunodeficiency
virus 1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 GLY A 302
ASP A 305
TYR A 304
ARG A 676
 None
 1.19A 3aruA-5i08A:
undetectable		 3aruA-5i08A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A1349
GLY A1635
TRP A1549
ARG A1544
 None
 1.26A 3aruA-5i8iA:
undetectable		 3aruA-5i8iA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		4 GLY A 167
LYS A 129
TYR A 147
ARG A 144
 None
 1.24A 3aruA-5iryA:
3.0		 3aruA-5iryA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz7 MEDI578 SCFV, HEAVY
CHAIN
MEDI578 SCFV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 GLY C  33
ASP C 100
TRP D  96
TYR C 100
 None
 1.24A 3aruA-5jz7C:
6.7		 3aruA-5jz7C:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 182
ASP A 197
TRP A 242
ARG A 240
 None
 0.86A 3aruA-5olsA:
undetectable		 3aruA-5olsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 GLY A 260
ASP A 286
TRP A 291
ARG A 342
 NAG  A 502 ( 3.9A)
NAG  A 504 (-3.5A)
NAG  A 502 (-4.0A)
NAG  A 503 (-3.7A)
 0.67A 3aruA-5wvbA:
39.8		 3aruA-5wvbA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		4 PHE A 142
GLY A 139
LYS A 137
TYR A 555
 None
 1.26A 3aruA-5wx1A:
undetectable		 3aruA-5wx1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvi GLUTAMATE
DEHYDROGENASE

(Aspergillus
niger) 		no annotation 4 PHE A 166
GLY A 189
LYS A 183
ARG A 396
 None
GOL  A 501 ( 4.2A)
None
None
 1.04A 3aruA-5xviA:
undetectable		 3aruA-5xviA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 4 PHE A 137
GLY A 376
ASP A 174
ARG A 526
 None
 1.18A 3aruA-5yy3A:
2.8		 3aruA-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 GLY A 366
ASP A 393
TYR A 420
ARG A 448
 None
GOL  A 703 (-3.0A)
None
GOL  A 703 (-4.0A)
 0.81A 3aruA-5zl9A:
55.5		 3aruA-5zl9A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 4 PHE A 316
GLY A 366
ASP A 393
ARG A 448
 None
None
GOL  A 703 (-3.0A)
GOL  A 703 (-4.0A)
 0.63A 3aruA-5zl9A:
55.5		 3aruA-5zl9A:
9.57