SIMILAR PATTERNS OF AMINO ACIDS FOR 3ARR_A_PNXA607_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		4 VAL A 136
SER A 110
HIS A 263
THR A 242
 None
 1.22A 3arrA-1c4xA:
1.0		 3arrA-1c4xA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1djp GLUTAMINASE-ASPARAGI
NASE

(Pseudomonas sp.
7A) 		PF00710
(Asparaginase) 		4 VAL A1233
SER A1229
HIS A1251
LEU A1267
 None
 1.22A 3arrA-1djpA:
1.9		 3arrA-1djpA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ftp MUSCLE FATTY ACID
BINDING PROTEIN

(Schistocerca
gregaria) 		PF00061
(Lipocalin) 		4 VAL A  82
SER A  84
HIS A  96
THR A  76
 None
 0.81A 3arrA-1ftpA:
undetectable		 3arrA-1ftpA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm7 PENTALENENE SYNTHASE

(Streptomyces
exfoliatus) 		no annotation 4 VAL A  70
SER A  74
HIS A  45
LEU A  27
 None
 0.90A 3arrA-1hm7A:
1.0		 3arrA-1hm7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kke SIGMA 1 PROTEIN

(Mammalian
orthoreovirus) 		PF01664
(Reo_sigma1) 		4 VAL A 337
SER A 339
LEU A 368
TRP A 333
 None
 1.20A 3arrA-1kkeA:
undetectable		 3arrA-1kkeA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n26 IL-6 RECEPTOR ALPHA
CHAIN

(Homo sapiens) 		PF00047
(ig)
PF09240
(IL6Ra-bind) 		4 VAL A 179
SER A 177
THR A  17
LEU A  90
 None
 1.19A 3arrA-1n26A:
6.8		 3arrA-1n26A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE

(Pseudomonas sp.
P51) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 356
HIS A 310
LEU A 348
TRP A 328
 None
 1.19A 3arrA-1nu5A:
5.6		 3arrA-1nu5A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8v FATTY ACID BINDING
PROTEIN HOMOLOG

(Echinococcus
granulosus) 		PF00061
(Lipocalin) 		4 VAL A  81
SER A  83
HIS A  94
THR A  75
 None
None
CSO  A  63 ( 4.8A)
PLM  A1136 ( 4.9A)
 0.79A 3arrA-1o8vA:
undetectable		 3arrA-1o8vA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obf GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Achromobacter
xylosoxidans) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL O   4
HIS O  20
THR O 328
LEU O 325
 None
 1.23A 3arrA-1obfO:
undetectable		 3arrA-1obfO:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgi PROTEIN
(CHITOSANASE)

(Bacillus
circulans) 		PF01374
(Glyco_hydro_46) 		4 VAL A 153
THR A  19
LEU A  21
TRP A 141
 None
 1.20A 3arrA-1qgiA:
undetectable		 3arrA-1qgiA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqi 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Rattus
norvegicus) 		PF00903
(Glyoxalase) 		4 VAL A  70
SER A  21
HIS A  20
LEU A 157
 None
 1.01A 3arrA-1sqiA:
undetectable		 3arrA-1sqiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT
ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 VAL D  48
THR C 218
LEU C 219
TRP C  15
 None
 1.22A 3arrA-1sxjD:
undetectable		 3arrA-1sxjD:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 VAL A  80
SER A  82
HIS A  93
THR A  74
 None
 0.60A 3arrA-1towA:
undetectable		 3arrA-1towA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux4 BNI1 PROTEIN

(Saccharomyces
cerevisiae) 		PF02181
(FH2) 		4 VAL A1659
SER A1662
THR A1684
LEU A1681
 None
 1.07A 3arrA-1ux4A:
3.1		 3arrA-1ux4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v96 HYPOTHETICAL PROTEIN
PH0500

(Pyrococcus
horikoshii) 		no annotation 4 VAL A  35
HIS A  18
THR A  29
LEU A  26
 None
 1.13A 3arrA-1v96A:
undetectable		 3arrA-1v96A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		4 VAL A 368
SER A 410
HIS A 415
THR A 404
 None
 0.98A 3arrA-1x0uA:
undetectable		 3arrA-1x0uA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y11 HYPOTHETICAL PROTEIN
RV1264/MT1302

(Mycobacterium
tuberculosis) 		PF00211
(Guanylate_cyc)
PF16701
(Ad_Cy_reg) 		4 VAL A 171
THR A  56
LEU A  53
TRP A  34
 1PE  A 409 ( 4.7A)
1PE  A 409 ( 4.7A)
1PE  A 409 ( 4.1A)
None
 1.22A 3arrA-1y11A:
undetectable		 3arrA-1y11A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y82 HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF01850
(PIN) 		4 VAL A  35
HIS A  18
THR A  29
LEU A  26
 None
 1.13A 3arrA-1y82A:
undetectable		 3arrA-1y82A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 VAL A 418
SER A 470
HIS A 464
THR A 422
 None
4EB  A1000 ( 4.4A)
4EB  A1000 (-2.7A)
4EB  A1000 (-3.9A)
 1.17A 3arrA-1ysxA:
undetectable		 3arrA-1ysxA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chr CHLOROMUCONATE
CYCLOISOMERASE

(Cupriavidus
necator) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A  26
THR A  15
LEU A 330
TRP A 136
 None
 1.19A 3arrA-2chrA:
5.6		 3arrA-2chrA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 VAL A 713
SER A 705
HIS A 641
LEU A 825
 None
 1.10A 3arrA-2hg4A:
undetectable		 3arrA-2hg4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		4 VAL A 679
HIS A 696
THR A 704
LEU A 700
 None
 1.19A 3arrA-2hwkA:
undetectable		 3arrA-2hwkA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 VAL A 561
SER A 423
THR A 586
LEU A 588
 None
 1.22A 3arrA-2iu3A:
undetectable		 3arrA-2iu3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nql ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A  19
SER A 345
HIS A 344
LEU A 171
 None
 1.12A 3arrA-2nqlA:
1.3		 3arrA-2nqlA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 TRP A 477
VAL A 623
THR A 613
LEU A 492
 None
 1.16A 3arrA-2o2qA:
undetectable		 3arrA-2o2qA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		4 VAL B 529
HIS B 102
THR B 252
LEU B 255
 None
 1.22A 3arrA-2pffB:
2.5		 3arrA-2pffB:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF01728
(FtsJ) 		4 VAL A 152
SER A 112
THR A 133
LEU A 132
 None
None
None
SAM  A 203 (-4.9A)
 1.22A 3arrA-2plwA:
undetectable		 3arrA-2plwA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		4 SER A 248
HIS A 250
LEU A 290
TRP A 226
 None
 1.21A 3arrA-2q01A:
4.8		 3arrA-2q01A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq2 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE

(Homo sapiens) 		PF03061
(4HBT) 		4 VAL A 235
HIS A 222
THR A 240
LEU A 243
 None
 0.77A 3arrA-2qq2A:
undetectable		 3arrA-2qq2A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		4 VAL A 380
SER A 532
THR A 384
LEU A 387
 None
 1.21A 3arrA-2qykA:
undetectable		 3arrA-2qykA:
18.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		6 TRP A 167
SER A 210
HIS A 229
THR A 276
LEU A 277
TRP A 539
 SN5  A1563 ( 4.0A)
SN5  A1563 (-3.6A)
SN5  A1563 ( 4.7A)
SN5  A1563 ( 3.3A)
None
NGT  A1565 ( 3.5A)
 0.69A 3arrA-2wk2A:
57.3		 3arrA-2wk2A:
51.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		4 VAL A  18
HIS A 249
LEU A   8
TRP A 365
 None
 1.22A 3arrA-2xkaA:
undetectable		 3arrA-2xkaA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 VAL A 247
HIS A  78
THR A 166
LEU A 169
 None
 1.08A 3arrA-2zzgA:
undetectable		 3arrA-2zzgA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		7 TRP A 168
VAL A 205
SER A 209
HIS A 228
THR A 276
LEU A 277
TRP A 570
 None
 0.57A 3arrA-3b9eA:
64.6		 3arrA-3b9eA:
99.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE, ADP-BINDING
SUBUNIT DHAL

(Lactococcus
lactis) 		PF02734
(Dak2) 		4 TRP A  10
VAL A 191
THR A 100
LEU A 103
 None
 1.07A 3arrA-3cr3A:
undetectable		 3arrA-3cr3A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr3 PTS-DEPENDENT
DIHYDROXYACETONE
KINASE, ADP-BINDING
SUBUNIT DHAL

(Lactococcus
lactis) 		PF02734
(Dak2) 		4 TRP A  10
VAL A 191
THR A 100
TRP A 128
 None
 0.98A 3arrA-3cr3A:
undetectable		 3arrA-3cr3A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		4 VAL A 141
SER A 137
HIS A 148
TRP A 225
 None
 1.13A 3arrA-3cskA:
undetectable		 3arrA-3cskA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 SER A  35
HIS A 317
LEU A 207
TRP A 183
 None
 1.02A 3arrA-3g8mA:
undetectable		 3arrA-3g8mA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		4 SER A  15
HIS A  17
THR A  58
TRP A 389
 None
 1.19A 3arrA-3ie1A:
undetectable		 3arrA-3ie1A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		4 VAL A 123
SER A 126
THR A  89
LEU A  93
 None
 1.15A 3arrA-3l4eA:
undetectable		 3arrA-3l4eA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 VAL A 242
SER A 394
THR A 246
LEU A 249
 None
 1.20A 3arrA-3o57A:
undetectable		 3arrA-3o57A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obz PHYTANOYL-COA
DIOXYGENASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05721
(PhyH) 		4 HIS A 110
THR A 281
LEU A 284
TRP A 277
 None
 1.15A 3arrA-3obzA:
undetectable		 3arrA-3obzA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6d PROLINE DIPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 SER A 102
HIS A 106
THR A  22
LEU A  20
 None
 1.23A 3arrA-3q6dA:
undetectable		 3arrA-3q6dA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpl HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 VAL A 194
SER A 186
THR A 202
LEU A 203
 None
 1.22A 3arrA-3qplA:
undetectable		 3arrA-3qplA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 VAL A 318
SER A 419
THR A 370
LEU A 371
 None
 1.22A 3arrA-3rc0A:
undetectable		 3arrA-3rc0A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		4 VAL A 135
SER A 170
THR A 298
LEU A 307
 None
 1.05A 3arrA-3s99A:
undetectable		 3arrA-3s99A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		4 VAL A 395
SER A 404
LEU A 448
TRP A 551
 None
 1.12A 3arrA-3tlmA:
undetectable		 3arrA-3tlmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		4 VAL A  80
SER A  82
HIS A  93
THR A  74
 None
 0.50A 3arrA-3wbgA:
undetectable		 3arrA-3wbgA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmr PROLINE
IMINOPEPTIDASE

(Streptomyces
halstedii) 		PF00561
(Abhydrolase_1) 		4 TRP A 111
VAL A 210
LEU A  86
TRP A 229
 None
None
None
P4G  A 402 (-4.4A)
 1.10A 3arrA-3wmrA:
undetectable		 3arrA-3wmrA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbi TRAF PROTEIN
TRAO PROTEIN

(Escherichia
coli) 		PF03524
(CagX)
PF03743
(TrbI) 		4 SER A 886
THR B 974
LEU B 975
TRP B 997
 None
 1.15A 3arrA-3zbiA:
undetectable		 3arrA-3zbiA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP

(Homo sapiens) 		PF00061
(Lipocalin) 		4 VAL A  81
SER A  83
HIS A  94
THR A  75
 None
None
None
EDO  A1134 ( 4.9A)
 0.56A 3arrA-4a60A:
undetectable		 3arrA-4a60A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 VAL A 698
SER A 559
THR A 652
TRP A 659
 None
 1.20A 3arrA-4av6A:
undetectable		 3arrA-4av6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL PROTEIN
SKI8

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 VAL C 192
HIS C  67
THR C 144
TRP C 153
 None
 1.10A 3arrA-4bujC:
undetectable		 3arrA-4bujC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 VAL A 366
HIS A 376
THR A 516
LEU A 517
 None
 1.03A 3arrA-4e1jA:
undetectable		 3arrA-4e1jA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 VAL A 296
SER A 250
THR A 122
LEU A 319
 None
 1.03A 3arrA-4fnqA:
4.7		 3arrA-4fnqA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF01403
(Sema) 		4 SER A 134
HIS A 146
THR A  93
LEU A  91
 ACT  A 610 (-3.1A)
None
ACT  A 610 (-3.7A)
None
 1.21A 3arrA-4fwwA:
undetectable		 3arrA-4fwwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TRP A 119
VAL A 514
SER A 321
THR A 557
 None
None
None
FED  A 801 (-3.7A)
 1.09A 3arrA-4h7uA:
undetectable		 3arrA-4h7uA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdi IG HEAVY CHAIN V
REGION RF, IG
GAMMA-3 CHAIN C
REGION

(Mus musculus) 		no annotation 4 TRP H 195
VAL H 143
SER H 192
THR H 138
 None
 1.20A 3arrA-4hdiH:
6.4		 3arrA-4hdiH:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2n GP37

(Mycobacterium
virus Pukovnik) 		PF12728
(HTH_17) 		4 VAL A  42
SER A  46
THR A  10
LEU A  14
 None
 0.82A 3arrA-4j2nA:
undetectable		 3arrA-4j2nA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 TRP A 118
VAL A 122
THR A 227
LEU A 228
 None
None
None
EDO  A1006 ( 4.2A)
 1.18A 3arrA-4knhA:
undetectable		 3arrA-4knhA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		4 VAL A 124
SER A 154
LEU A 169
TRP A 120
 SAH  A 401 (-4.6A)
SAH  A 401 (-3.0A)
None
None
 1.21A 3arrA-4m38A:
undetectable		 3arrA-4m38A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		4 SER A 159
THR A 108
LEU A 112
TRP A 201
 None
 1.14A 3arrA-4n2xA:
undetectable		 3arrA-4n2xA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE

(Homo sapiens) 		PF00061
(Lipocalin) 		4 VAL A  80
SER A  82
HIS A  93
THR A  74
 None
 0.57A 3arrA-4nnsA:
undetectable		 3arrA-4nnsA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 TRP A 369
VAL A 372
THR A 381
LEU A 382
 HIS  A 502 (-3.3A)
None
None
None
 1.23A 3arrA-4oflA:
undetectable		 3arrA-4oflA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER A 184
HIS A 185
THR A 178
LEU A 177
 None
 1.20A 3arrA-4qciA:
6.5		 3arrA-4qciA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH

(Homo sapiens) 		no annotation 4 SER A1053
HIS A1057
THR A1400
LEU A1403
 None
 1.14A 3arrA-4qn1A:
undetectable		 3arrA-4qn1A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7b CHOLINE KINASE

(Streptococcus
pneumoniae) 		PF01633
(Choline_kinase) 		4 VAL A 156
THR A 249
LEU A 253
TRP A 205
 None
 1.05A 3arrA-4r7bA:
undetectable		 3arrA-4r7bA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlq BENZOATE-COENZYME A
LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 352
SER A 337
THR A 209
LEU A 210
 None
 1.17A 3arrA-4rlqA:
undetectable		 3arrA-4rlqA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		4 VAL A 414
SER A 566
THR A 418
LEU A 421
 None
 1.20A 3arrA-4wziA:
undetectable		 3arrA-4wziA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN SEH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 VAL C  59
SER C  57
LEU C  11
TRP C 308
 None
 1.17A 3arrA-4xmmC:
undetectable		 3arrA-4xmmC:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 SER A 620
HIS A 615
THR A 700
LEU A 698
 None
 1.19A 3arrA-4zg7A:
undetectable		 3arrA-4zg7A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 TRP A 571
VAL A 527
SER A 521
HIS A 122
 None
 1.21A 3arrA-4ztxA:
9.3		 3arrA-4ztxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b29 FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		4 VAL A  80
SER A  82
HIS A  93
THR A  74
 None
 0.55A 3arrA-5b29A:
undetectable		 3arrA-5b29A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		4 TRP A 490
VAL A 470
THR A 505
LEU A 509
 None
 1.20A 3arrA-5b3hA:
undetectable		 3arrA-5b3hA:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 SER A 200
HIS A 219
THR A 266
LEU A 267
TRP A 528
 None
None
SN5  A 604 (-3.1A)
None
58Y  A 605 (-3.7A)
 0.79A 3arrA-5df0A:
55.0		 3arrA-5df0A:
44.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 TRP A 157
SER A 200
HIS A 219
THR A 266
LEU A 267
 None
None
None
SN5  A 604 (-3.1A)
None
 0.56A 3arrA-5df0A:
55.0		 3arrA-5df0A:
44.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Francisella
tularensis) 		PF00005
(ABC_tran) 		4 SER A 445
HIS A 446
THR A 439
LEU A 438
 None
 1.11A 3arrA-5dgxA:
undetectable		 3arrA-5dgxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 SER A 620
HIS A 499
THR A 648
LEU A 628
 None
 1.14A 3arrA-5djwA:
3.1		 3arrA-5djwA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Homo sapiens) 		PF00903
(Glyoxalase)
PF13669
(Glyoxalase_4) 		4 VAL A  70
SER A  21
HIS A  20
LEU A 157
 VAL  A  70 ( 0.6A)
SER  A  21 ( 0.0A)
HIS  A  20 ( 1.0A)
LEU  A 157 ( 0.6A)
 1.07A 3arrA-5ec3A:
undetectable		 3arrA-5ec3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		4 VAL A 255
SER A 139
THR A 303
LEU A 352
 None
 1.15A 3arrA-5ejjA:
undetectable		 3arrA-5ejjA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis) 		PF01425
(Amidase) 		4 VAL A 448
SER A 451
THR A 282
LEU A 283
 None
 1.09A 3arrA-5ewqA:
undetectable		 3arrA-5ewqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE

(Mycobacterium
marinum) 		PF03492
(Methyltransf_7) 		4 SER A  71
HIS A  96
THR A 110
LEU A 111
 SAH  A 400 ( 4.8A)
None
None
None
 1.08A 3arrA-5f2oA:
undetectable		 3arrA-5f2oA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		6 TRP A 160
SER A 203
HIS A 222
THR A 269
LEU A 270
TRP A 532
 TRP  A 160 ( 0.5A)
SER  A 203 ( 0.0A)
HIS  A 222 ( 1.0A)
THR  A 269 ( 0.8A)
LEU  A 270 ( 0.6A)
TRP  A 532 ( 0.5A)
 0.59A 3arrA-5gprA:
56.3		 3arrA-5gprA:
50.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo5 10E8 GLV

(Homo sapiens) 		no annotation 4 SER L 187
HIS L 188
THR L 181
LEU L 180
 None
 1.22A 3arrA-5jo5L:
6.5		 3arrA-5jo5L:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo8 CEP104

(Gallus gallus) 		no annotation 4 VAL A  91
SER A 106
THR A 135
LEU A 139
 None
 1.05A 3arrA-5jo8A:
undetectable		 3arrA-5jo8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 VAL A  57
SER A  50
THR A 108
TRP A 133
 None
 1.16A 3arrA-5jowA:
undetectable		 3arrA-5jowA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lph CENTROSOMAL PROTEIN
OF 104 KDA

(Homo sapiens) 		no annotation 4 VAL A 485
SER A 500
THR A 529
LEU A 533
 None
 1.09A 3arrA-5lphA:
undetectable		 3arrA-5lphA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A1111
THR A1081
LEU A1077
TRP A 980
 None
 1.23A 3arrA-5lpyA:
undetectable		 3arrA-5lpyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 VAL A1111
THR A1081
LEU A1077
TRP A 980
 None
 1.20A 3arrA-5lpzA:
undetectable		 3arrA-5lpzA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m76 LIGHT CHAIN DIMER

(Homo sapiens) 		no annotation 4 SER A 190
HIS A 191
THR A 184
LEU A 183
 None
 1.22A 3arrA-5m76A:
6.8		 3arrA-5m76A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhr VIRAL ATTACHMENT
PROTEIN SIGMA 1

(Reovirus sp.) 		PF01664
(Reo_sigma1) 		4 VAL A 337
SER A 339
LEU A 368
TRP A 333
 None
 1.19A 3arrA-5mhrA:
undetectable		 3arrA-5mhrA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5s RNASE ADAPTER
PROTEIN RAPZ

(Escherichia
coli) 		PF03668
(ATP_bind_2) 		4 SER A 166
HIS A 276
THR A 199
LEU A 201
 None
 1.20A 3arrA-5o5sA:
undetectable		 3arrA-5o5sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 4 VAL A 414
SER A 566
THR A 418
LEU A 421
 None
 1.21A 3arrA-5ohjA:
undetectable		 3arrA-5ohjA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t77 PUTATIVE LIPID II
FLIPPASE MURJ

(Thermosipho
africanus) 		PF03023
(MVIN) 		4 VAL A 266
SER A 348
THR A 270
LEU A 273
 None
 1.16A 3arrA-5t77A:
undetectable		 3arrA-5t77A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 VAL A 485
THR A 299
LEU A 298
TRP A 335
 None
None
EST  A 601 (-4.1A)
None
 1.03A 3arrA-5toaA:
undetectable		 3arrA-5toaA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		4 VAL A 415
SER A 417
THR A 502
LEU A 503
 None
 0.85A 3arrA-5txeA:
undetectable		 3arrA-5txeA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 4 VAL A  37
SER A  30
THR A  88
TRP A 113
 None
 1.16A 3arrA-5z5dA:
undetectable		 3arrA-5z5dA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zl9 CHITINASE AB

(Serratia
marcescens) 		no annotation 6 TRP A 167
SER A 210
HIS A 229
THR A 276
LEU A 277
TRP A 541
 GOL  A 707 (-4.0A)
GOL  A 707 (-3.2A)
GOL  A 707 (-3.7A)
None
None
GOL  A 706 ( 3.8A)
 0.71A 3arrA-5zl9A:
55.9		 3arrA-5zl9A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 4 TRP A 679
VAL A 337
THR A 458
LEU A 463
 None
 1.18A 3arrA-6azpA:
undetectable		 3arrA-6azpA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fos PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Cyanidioschyzon
merolae) 		no annotation 4 VAL B 604
SER B 598
THR B 509
LEU B 508
 None
 1.22A 3arrA-6fosB:
undetectable		 3arrA-6fosB:
9.71