SIMILAR PATTERNS OF AMINO ACIDS FOR 3ARR_A_PNXA606

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)

(Amycolatopsis
mediterranei) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLY A 137
ASP A 282
TRP A 168
ARG A 284
 None
 1.05A 3arrA-1b9hA:
undetectable		 3arrA-1b9hA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 GLY A 532
ASP A 598
TRP A 603
ARG A 187
 None
 0.89A 3arrA-1bf2A:
5.9		 3arrA-1bf2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		4 GLY A1188
LYS A1307
ASP A1191
ARG A1288
 None
 1.11A 3arrA-1c0iA:
undetectable		 3arrA-1c0iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 GLY A 552
LYS A 553
ASP A 610
TYR A 604
 None
 1.27A 3arrA-1cygA:
9.8		 3arrA-1cygA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 GLY A 171
ASP A 110
TRP A 114
ARG A 113
 None
ZN  A 501 (-2.0A)
None
None
 1.27A 3arrA-1czfA:
undetectable		 3arrA-1czfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis) 		PF00704
(Glyco_hydro_18) 		4 GLY A 215
ASP A 240
TRP A 245
ARG A 295
 None
 0.60A 3arrA-1d2kA:
41.1		 3arrA-1d2kA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2k CHITINASE 1

(Coccidioides
immitis) 		PF00704
(Glyco_hydro_18) 		4 TRP A 131
ASP A 240
TRP A 245
ARG A 295
 None
 0.89A 3arrA-1d2kA:
41.1		 3arrA-1d2kA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 TRP A  97
GLY A 187
TRP A 220
ARG A 294
 NAG  A 503 ( 3.7A)
None
NAG  A 504 (-3.6A)
NAG  A 503 ( 4.9A)
 1.12A 3arrA-1e6zA:
33.5		 3arrA-1e6zA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 TRP A  97
GLY A 188
ASP A 215
TRP A 220
ARG A 294
 NAG  A 503 ( 3.7A)
NAG  A 504 ( 4.9A)
NGO  A 502 ( 3.1A)
NAG  A 504 (-3.6A)
NAG  A 503 ( 4.9A)
 0.82A 3arrA-1e6zA:
33.5		 3arrA-1e6zA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eif EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5A

(Methanocaldococcus
jannaschii) 		PF01287
(eIF-5a)
PF08207
(EFP_N) 		4 GLY A   6
LYS A   4
ASP A  75
ARG A  77
 None
 1.01A 3arrA-1eifA:
undetectable		 3arrA-1eifA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 TRP A  99
GLY A 181
ASP A 207
ARG A 263
 NAG  A   1 (-3.6A)
NAG  A   2 (-3.3A)
NAG  A  -1 (-3.7A)
NAG  A  -2 (-4.2A)
 0.77A 3arrA-1hjvA:
20.1		 3arrA-1hjvA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 TRP A  99
GLY A 187
ASP A 213
TRP A 218
ARG A 269
 NAA  A1390 ( 4.3A)
AMI  A1391 (-3.3A)
AMI  A1388 ( 2.9A)
NAA  A1390 (-3.2A)
NAA  A1389 (-3.2A)
 0.60A 3arrA-1hkkA:
42.2		 3arrA-1hkkA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		4 GLY A 253
ASP A 280
TRP A 285
ARG A 340
 GOL  A1008 (-3.5A)
None
None
None
 0.97A 3arrA-1itxA:
45.2		 3arrA-1itxA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		4 TRP A 164
ASP A 280
TRP A 285
ARG A 340
 None
 0.55A 3arrA-1itxA:
45.2		 3arrA-1itxA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		4 TRP A 136
ASP A 272
TRP A 277
ARG A 330
 None
GOL  A 530 (-3.7A)
None
None
 0.42A 3arrA-1kfwA:
39.8		 3arrA-1kfwA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 GLY A 385
LYS A 388
TYR A 350
ARG A 348
 None
 0.94A 3arrA-1kl7A:
undetectable		 3arrA-1kl7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhc POLYGALACTURONASE I

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		4 GLY A 177
ASP A 115
TRP A 119
ARG A 118
 None
 1.23A 3arrA-1nhcA:
undetectable		 3arrA-1nhcA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01798
(Nop) 		4 GLY B  53
ASP B  60
TYR B  61
ARG B  63
 None
 1.16A 3arrA-1nt2B:
undetectable		 3arrA-1nt2B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o75 47 KDA MEMBRANE
ANTIGEN

(Treponema
pallidum) 		PF14888
(PBP-Tp47_c)
PF14889
(PBP-Tp47_a) 		4 GLY A 264
ASP A 261
TYR A 262
ARG A 259
 None
 1.29A 3arrA-1o75A:
undetectable		 3arrA-1o75A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qo8 FLAVOCYTOCHROME C3
FUMARATE REDUCTASE

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 TRP A 186
GLY A 179
ASP A 182
ARG A 238
 None
 1.34A 3arrA-1qo8A:
undetectable		 3arrA-1qo8A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		4 GLY A 178
ASP A 194
TRP A 229
ARG A 227
 None
 0.78A 3arrA-1ru4A:
undetectable		 3arrA-1ru4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 GLY A  75
ASP A  82
TYR A  29
ARG A  86
 None
 1.30A 3arrA-1ufaA:
3.5		 3arrA-1ufaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ver NEW ANTIGEN RECEPTOR
VARIABLE DOMAIN

(Orectolobus
maculatus) 		PF07686
(V-set) 		4 GLY A 105
ASP A   4
TRP A   2
ARG A  25
 None
 1.22A 3arrA-1verA:
3.5		 3arrA-1verA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ves NEW ANTIGEN RECEPTOR
VARIABLE DOMAIN

(Orectolobus
maculatus) 		PF07686
(V-set) 		4 GLY A 107
ASP A   4
TRP A   2
ARG A  25
 None
 1.15A 3arrA-1vesA:
5.2		 3arrA-1vesA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		4 TRP A 141
GLY A 167
ASP A 172
ARG A 175
 None
 0.95A 3arrA-1w6jA:
undetectable		 3arrA-1w6jA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 TRP A  99
GLY A 187
ASP A 213
ARG A 269
 None
 0.80A 3arrA-1wb0A:
41.9		 3arrA-1wb0A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 TRP A 454
GLY A 201
ASP A 168
ARG A 242
 None
 1.29A 3arrA-1wd3A:
undetectable		 3arrA-1wd3A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		5 TRP A  99
GLY A 183
LYS A 186
ASP A 208
ARG A 263
 None
 0.84A 3arrA-1wnoA:
41.1		 3arrA-1wnoA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxx HYPOTHETICAL PROTEIN
TTHA1280

(Thermus
thermophilus) 		PF10672
(Methyltrans_SAM) 		4 GLY A 115
ASP A 111
TYR A 112
ARG A  96
 None
 1.19A 3arrA-1wxxA:
undetectable		 3arrA-1wxxA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		4 GLY A 133
ASP A  74
TYR A  68
ARG A  15
 None
 1.34A 3arrA-1y5eA:
undetectable		 3arrA-1y5eA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 335
ASP A 329
TYR A 330
ARG A 310
 None
 1.07A 3arrA-2bucA:
undetectable		 3arrA-2bucA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE

(Thermus
thermophilus) 		PF00483
(NTP_transferase) 		4 TRP A 185
GLY A 113
ASP A 254
ARG A 264
 None
 1.31A 3arrA-2cu2A:
undetectable		 3arrA-2cu2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01409
(tRNA-synt_2d) 		4 GLY A 339
ASP A 342
TYR A 340
ARG A 344
 None
 1.27A 3arrA-2du3A:
undetectable		 3arrA-2du3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr5 CYTIDINE DEAMINASE

(Mus musculus) 		PF00383
(dCMP_cyt_deam_1) 		4 GLY A  78
ASP A  81
TYR A  79
ARG A  83
 None
 1.10A 3arrA-2fr5A:
undetectable		 3arrA-2fr5A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 335
ASP A 329
TYR A 330
ARG A 310
 None
 1.12A 3arrA-2g5tA:
undetectable		 3arrA-2g5tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 4 GLY A 253
LYS A 256
ASP A 243
TYR A 247
 None
None
ZN  A 601 (-2.2A)
None
 0.94A 3arrA-2hihA:
undetectable		 3arrA-2hihA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7v TLL2115 PROTEIN

(Synechococcus
elongatus) 		PF13354
(Beta-lactamase2) 		4 GLY A 211
ASP A 234
TYR A 268
ARG A 240
 None
 1.22A 3arrA-2j7vA:
undetectable		 3arrA-2j7vA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcj N-ACETYLLACTOSAMINID
E
ALPHA-1,3-GALACTOSYL
TRANSFERASE

(Bos taurus) 		PF03414
(Glyco_transf_6) 		4 GLY A 275
ASP A 257
TRP A 250
TYR A 260
 None
 0.93A 3arrA-2jcjA:
undetectable		 3arrA-2jcjA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb7 E3 UBIQUITIN-PROTEIN
LIGASE UHRF1

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 GLY A 557
ASP A 583
TYR A 559
ARG A 528
 None
 1.30A 3arrA-2pb7A:
undetectable		 3arrA-2pb7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxx UNCHARACTERIZED
PROTEIN MGC2408

(Homo sapiens) 		PF08241
(Methyltransf_11) 		4 TRP A  41
GLY A 139
LYS A  17
ASP A 134
 SAH  A 301 (-3.9A)
None
None
None
 0.98A 3arrA-2pxxA:
undetectable		 3arrA-2pxxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 GLY A 183
ASP A 259
TRP A 254
ARG A 263
 None
 0.80A 3arrA-2q3zA:
3.2		 3arrA-2q3zA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8a LONG-CHAIN FATTY
ACID TRANSPORT
PROTEIN

(Escherichia
coli) 		PF03349
(Toluene_X) 		4 GLY A  12
LYS A   9
TYR A  17
ARG A 228
 None
 0.96A 3arrA-2r8aA:
undetectable		 3arrA-2r8aA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmj DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
xylosoxidans) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 GLY A 245
ASP A 263
TYR A 279
ARG A 262
 None
 1.23A 3arrA-2vmjA:
undetectable		 3arrA-2vmjA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wk2 CHITINASE A

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		6 TRP A 275
GLY A 366
LYS A 369
ASP A 391
TYR A 418
ARG A 446
 SN5  A1566 (-3.3A)
SN5  A1567 ( 4.5A)
SN5  A1567 (-3.2A)
NGT  A1565 (-2.9A)
SN5  A1567 (-2.9A)
SN5  A1566 ( 3.5A)
 0.63A 3arrA-2wk2A:
57.3		 3arrA-2wk2A:
51.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		4 TRP A  17
GLY A 277
ASP A 297
ARG A 535
 None
 1.18A 3arrA-2wokA:
undetectable		 3arrA-2wokA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2g TRIOSEPHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00121
(TIM) 		4 GLY A 230
ASP A 227
TYR A 223
ARG A 226
 None
 1.10A 3arrA-2x2gA:
9.7		 3arrA-2x2gA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xst LIPOCALIN 15

(Homo sapiens) 		PF00061
(Lipocalin) 		4 GLY A 105
ASP A 108
TYR A 106
ARG A 110
 None
 1.21A 3arrA-2xstA:
undetectable		 3arrA-2xstA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 GLY A 471
ASP A 437
TYR A 473
ARG A 435
 PO4  A1505 (-3.4A)
NAG  A1502 (-3.2A)
PO4  A1506 (-4.7A)
NAG  A1502 (-3.7A)
 1.26A 3arrA-2xycA:
7.5		 3arrA-2xycA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzw ABC TRANSPORTER,
SOLUTE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF03480
(DctP) 		4 GLY A 151
ASP A 136
TYR A 149
ARG A 140
 None
 1.06A 3arrA-2zzwA:
undetectable		 3arrA-2zzwA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		6 TRP A 275
GLY A 367
ASP A 392
TRP A 397
TYR A 435
ARG A 463
 None
 0.61A 3arrA-3b9eA:
64.6		 3arrA-3b9eA:
99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		6 TRP A 275
GLY A 367
LYS A 370
ASP A 392
TRP A 397
ARG A 463
 None
 0.62A 3arrA-3b9eA:
64.6		 3arrA-3b9eA:
99.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		4 TRP A 234
GLY A 204
ASP A 201
ARG A 209
 None
 1.27A 3arrA-3btzA:
undetectable		 3arrA-3btzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		4 GLY H 297
ASP H 292
TYR H 233
ARG H 278
 None
 1.34A 3arrA-3c75H:
undetectable		 3arrA-3c75H:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emj INORGANIC
PYROPHOSPHATASE

(Rickettsia
prowazekii) 		PF00719
(Pyrophosphatase) 		4 GLY A  56
ASP A  42
TYR A  55
ARG A  43
 None
 1.10A 3arrA-3emjA:
undetectable		 3arrA-3emjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 GLY A 680
ASP A 744
TYR A 682
ARG A 735
 None
 1.33A 3arrA-3eqnA:
undetectable		 3arrA-3eqnA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6l CHITINASE

(Clonostachys
rosea) 		PF00704
(Glyco_hydro_18) 		4 TRP A 134
ASP A 243
TRP A 248
ARG A 298
 None
 0.84A 3arrA-3g6lA:
41.6		 3arrA-3g6lA:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc7 GENE 12 PROTEIN

(Mycobacterium
virus D29) 		PF01083
(Cutinase) 		4 GLY A  11
ASP A  25
TYR A  81
ARG A 244
 None
 1.14A 3arrA-3hc7A:
2.2		 3arrA-3hc7A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2k BREVIANAMIDE F
PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 GLY A 196
ASP A 191
TYR A  61
ARG A 113
 None
DST  A 501 ( 4.1A)
None
DST  A 501 (-2.8A)
 1.33A 3arrA-3o2kA:
undetectable		 3arrA-3o2kA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aspergillus
nidulans) 		PF01179
(Cu_amine_oxid)
PF09248
(DUF1965) 		4 GLY A 277
ASP A 258
TYR A 279
ARG A 256
 None
 1.11A 3arrA-3pgbA:
undetectable		 3arrA-3pgbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcz DNA REPAIR PROTEIN
RAD60
SUMO-CONJUGATING
ENZYME UBC9

(Schizosaccharomyces
pombe) 		PF00179
(UQ_con)
PF11976
(Rad60-SLD) 		4 GLY B  44
LYS B  59
TRP A 383
TYR B  25
 None
 0.91A 3arrA-3rczB:
undetectable		 3arrA-3rczB:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tis PROTEIN YRDA

(Escherichia
coli) 		PF00132
(Hexapep) 		4 GLY A 160
ASP A  86
TYR A 163
ARG A  57
 None
 1.21A 3arrA-3tisA:
undetectable		 3arrA-3tisA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1z HEAT SHOCK PROTEIN
16

(Schizosaccharomyces
pombe) 		PF00011
(HSP20) 		4 GLY A  69
ASP A 111
TYR A  66
ARG A 114
 None
 1.33A 3arrA-3w1zA:
undetectable		 3arrA-3w1zA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 TRP A 107
ASP A 218
TRP A 223
ARG A 274
 None
 0.74A 3arrA-3w4rA:
41.1		 3arrA-3w4rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 TRP A 107
ASP A 218
TRP A 223
ARG A 274
 NAG  A 505 ( 3.4A)
NAG  A 501 ( 3.2A)
NAG  A 505 (-4.0A)
NAG  A 505 ( 3.6A)
 0.81A 3arrA-3wl1A:
41.1		 3arrA-3wl1A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 TRP A 215
ASP A 326
TYR A 352
ARG A 381
 None
 0.79A 3arrA-4a5qA:
34.7		 3arrA-4a5qA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 TRP A 308
GLY A 398
ASP A 425
ARG A 484
 None
 0.98A 3arrA-4dwsA:
35.4		 3arrA-4dwsA:
28.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		4 GLY A 445
LYS A 446
ASP A 466
ARG A 349
 None
 1.28A 3arrA-4e2iA:
undetectable		 3arrA-4e2iA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j35 PHOSPHOTRIESTERASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF02126
(PTE) 		4 GLY A 183
ASP A 206
TYR A 213
ARG A 243
 None
 1.17A 3arrA-4j35A:
4.6		 3arrA-4j35A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLY A 194
ASP A 113
TYR A 115
ARG A 205
 None
 1.17A 3arrA-4kxbA:
2.3		 3arrA-4kxbA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlk CT584 PROTEIN

(Chlamydia
trachomatis) 		PF17435
(DUF5414) 		4 GLY A  31
ASP A  93
TYR A  32
ARG A  97
 None
 1.21A 3arrA-4mlkA:
2.7		 3arrA-4mlkA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF02182
(SAD_SRA) 		4 GLY A 586
ASP A 613
TYR A 588
ARG A 557
 None
 1.24A 3arrA-4pw5A:
undetectable		 3arrA-4pw5A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		4 GLY A 323
ASP A 287
TYR A 285
ARG A 299
 None
 1.20A 3arrA-4qfuA:
5.4		 3arrA-4qfuA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 GLY A  20
ASP A  89
TYR A  26
ARG A  75
 None
 0.96A 3arrA-4rapA:
3.0		 3arrA-4rapA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxu PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Chloroflexus
aurantiacus) 		PF13407
(Peripla_BP_4) 		4 GLY A 117
ASP A 138
TRP A  65
ARG A  64
 None
BGC  A 402 (-3.0A)
BGC  A 402 (-4.3A)
BGC  A 402 (-3.9A)
 1.28A 3arrA-4rxuA:
undetectable		 3arrA-4rxuA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		4 TRP A 255
ASP A 398
TRP A 403
ARG A 466
 None
CS  A 812 (-4.0A)
None
None
 0.95A 3arrA-4txgA:
30.6		 3arrA-4txgA:
24.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 5 TRP B 142
LYS B 229
ASP B 251
TRP B 256
ARG B 307
 MLI  B 501 ( 3.8A)
None
MLI  B 501 ( 4.7A)
MLI  B 501 ( 4.2A)
None
 0.91A 3arrA-4w5uB:
43.4		 3arrA-4w5uB:
30.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxu MYOCILIN

(Homo sapiens) 		PF02191
(OLF) 		4 GLY A 292
ASP A 289
TRP A 489
ARG A 287
 None
 1.20A 3arrA-4wxuA:
undetectable		 3arrA-4wxuA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrn ALGINATE
BIOSYNTHESIS PROTEIN
ALG44

(Pseudomonas
aeruginosa) 		PF07238
(PilZ) 		4 GLY A  21
ASP A  28
TYR A  19
ARG A  16
 None
ZN  A 205 ( 1.9A)
None
None
 0.94A 3arrA-4xrnA:
2.2		 3arrA-4xrnA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		4 GLY A  92
ASP A 113
TRP A  40
ARG A  39
 None
XYP  A 401 (-3.3A)
None
XYP  A 401 (-3.9A)
 1.27A 3arrA-4ywhA:
undetectable		 3arrA-4ywhA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE

(Ruminococcus
albus) 		PF04041
(Glyco_hydro_130) 		4 TRP A 263
GLY A 173
LYS A 174
ASP A 260
 None
 1.29A 3arrA-5aydA:
undetectable		 3arrA-5aydA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8h TYPE III
PANTOTHENATE KINASE

(Burkholderia
cenocepacia) 		PF03309
(Pan_kinase) 		4 GLY A 196
ASP A 231
TYR A 199
ARG A 234
 None
 1.31A 3arrA-5b8hA:
undetectable		 3arrA-5b8hA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		7 TRP A 265
GLY A 357
LYS A 360
ASP A 382
TRP A 387
TYR A 409
ARG A 437
 NAG  A 603 ( 3.9A)
None
None
58Y  A 605 ( 3.0A)
NAG  A 603 (-4.5A)
None
58Y  A 605 ( 3.3A)
 0.71A 3arrA-5df0A:
55.0		 3arrA-5df0A:
44.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 GLY A 210
LYS A 213
ASP A 357
TYR A 209
 None
 1.34A 3arrA-5e84A:
undetectable		 3arrA-5e84A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A  82
ASP A  28
TYR A  32
ARG A  22
 None
 1.10A 3arrA-5gmsA:
undetectable		 3arrA-5gmsA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		7 TRP A 268
GLY A 359
LYS A 362
ASP A 384
TRP A 389
TYR A 411
ARG A 439
 TRP  A 268 ( 0.5A)
GLY  A 359 ( 0.0A)
LYS  A 362 ( 0.0A)
ASP  A 384 ( 0.5A)
TRP  A 389 (-0.5A)
TYR  A 411 ( 1.3A)
ARG  A 439 ( 0.6A)
 0.46A 3arrA-5gprA:
56.4		 3arrA-5gprA:
50.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 GLY A 578
ASP A 631
TRP A 638
ARG A 634
 None
 1.22A 3arrA-5gsmA:
9.8		 3arrA-5gsmA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 GLY B 740
ASP B 767
TRP B 772
ARG B 818
 None
 0.99A 3arrA-5gztB:
39.4		 3arrA-5gztB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 GLY A 740
ASP A 767
TRP A 772
ARG A 818
 None
 1.01A 3arrA-5gzuA:
40.1		 3arrA-5gzuA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
coronavirus
HKU1;
Human
immunodeficiency
virus 1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 GLY A 302
ASP A 305
TYR A 304
ARG A 676
 None
 1.20A 3arrA-5i08A:
undetectable		 3arrA-5i08A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		4 GLY A 167
LYS A 129
TYR A 147
ARG A 144
 None
 1.25A 3arrA-5iryA:
2.1		 3arrA-5iryA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TRP A 710
GLY A 627
ASP A 532
ARG A 538
 GAL  A1000 ( 3.8A)
None
GAL  A1000 (-3.1A)
GAL  A1000 (-4.4A)
 1.12A 3arrA-5k6oA:
undetectable		 3arrA-5k6oA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ols RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 182
ASP A 197
TRP A 242
ARG A 240
 None
 0.82A 3arrA-5olsA:
undetectable		 3arrA-5olsA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tkz MEC-8 PROTEIN

(Caenorhabditis
elegans) 		PF00076
(RRM_1) 		4 GLY A  59
ASP A  85
TYR A  57
ARG A  55
 None
 1.29A 3arrA-5tkzA:
undetectable		 3arrA-5tkzA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wa3 PYRIDINE SYNTHASE
TBTD

(Thermobispora
bispora) 		no annotation 4 TRP A 114
GLY A  17
ASP A  13
ARG A  11
 None
 1.16A 3arrA-5wa3A:
undetectable		 3arrA-5wa3A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 TRP A 176
ASP A 286
TRP A 291
ARG A 342
 NAG  A 503 (-3.3A)
NAG  A 504 (-3.5A)
NAG  A 502 (-4.0A)
NAG  A 503 (-3.7A)
 0.63A 3arrA-5wvbA:
40.0		 3arrA-5wvbA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 TRP A 176
GLY A 260
ASP A 286
ARG A 342
 NAG  A 503 (-3.3A)
NAG  A 502 ( 3.9A)
NAG  A 504 (-3.5A)
NAG  A 503 (-3.7A)
 0.53A 3arrA-5wvbA:
40.0		 3arrA-5wvbA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 TRP A 606
ASP A 716
TRP A 721
ARG A 772
 NAG  A1004 (-3.4A)
NAG  A1003 (-3.1A)
NAG  A1005 (-3.8A)
NAG  A1004 (-3.1A)
 0.56A 3arrA-5wvgA:
40.8		 3arrA-5wvgA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 282
LYS A 285
TRP A  90
TYR A  85
 None
 1.34A 3arrA-5xd7A:
6.7		 3arrA-5xd7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 4 TRP A 208
GLY A 171
ASP A 213
ARG A  41
 None
 1.09A 3arrA-5xmdA:
undetectable		 3arrA-5xmdA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 4 GLY A 261
LYS A 275
TRP A 117
TYR A 225
 None
 1.32A 3arrA-5y4gA:
undetectable		 3arrA-5y4gA:
undetectable