SIMILAR PATTERNS OF AMINO ACIDS FOR 3APV_A_TP0A190_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dxj | CLASS II CHITINASE (Canavaliaensiformis) |
PF00182(Glyco_hydro_19) | 5 | VAL A 88PHE A 61LEU A 62ALA A 34SER A 149 | None | 1.32A | 3apvA-1dxjA:undetectable | 3apvA-1dxjA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g6o | CAG-ALPHA (Helicobacterpylori) |
PF00437(T2SSE) | 5 | TYR A 326PHE A 257LEU A 261ALA A 280SER A 277 | None | 1.36A | 3apvA-1g6oA:0.0 | 3apvA-1g6oA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4l | CELL DIVISIONPROTEIN KINASE 5 (Homo sapiens) |
PF00069(Pkinase) | 5 | PHE A 80LEU A 66ALA A 148SER A 47TYR A 15 | None | 1.44A | 3apvA-1h4lA:0.0 | 3apvA-1h4lA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hjv | CHITINASE-3 LIKEPROTEIN 1 (Homo sapiens) |
PF00704(Glyco_hydro_18) | 5 | TYR A 27VAL A 25ALA A 138SER A 95SER A 175 | NAG A -1 (-3.8A)NoneNAG A -1 ( 3.9A)NoneNone | 1.42A | 3apvA-1hjvA:0.0 | 3apvA-1hjvA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ixr | HOLLIDAY JUNCTIONDNA HELICASE RUVA (Thermusthermophilus) |
PF01330(RuvA_N)PF14520(HHH_5) | 5 | PHE A 71PHE A 62LEU A 68GLU A 72ARG A 3 | None | 1.43A | 3apvA-1ixrA:0.0 | 3apvA-1ixrA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j93 | UROPORPHYRINOGENDECARBOXYLASE (Nicotianatabacum) |
PF01208(URO-D) | 5 | TYR A 251PHE A 343LEU A 300HIS A 329SER A 271 | SO4 A 584 (-4.5A)NoneNoneSO4 A 584 (-4.0A)None | 1.23A | 3apvA-1j93A:undetectable | 3apvA-1j93A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j93 | UROPORPHYRINOGENDECARBOXYLASE (Nicotianatabacum) |
PF01208(URO-D) | 5 | TYR A 251PHE A 343LEU A 300HIS A 329SER A 271 | SO4 A 584 (-4.5A)NoneNoneSO4 A 584 (-4.0A)None | 1.31A | 3apvA-1j93A:undetectable | 3apvA-1j93A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1miv | TRNA CCA-ADDINGENZYME (Geobacillusstearothermophilus) |
PF01743(PolyA_pol)PF12627(PolyA_pol_RNAbd)PF13735(tRNA_NucTran2_2) | 5 | PHE A 164LEU A 168GLU A 167ARG A 36ALA A 28 | None | 1.37A | 3apvA-1mivA:0.0 | 3apvA-1mivA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ogk | DEOXYURIDINETRIPHOSPHATASE (Trypanosomacruzi) |
PF08761(dUTPase_2) | 5 | PHE A 114LEU A 105GLU A 141ARG A 171SER A 85 | None | 1.10A | 3apvA-1ogkA:undetectable | 3apvA-1ogkA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1skx | ORPHAN NUCLEARRECEPTOR PXR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | PHE A 369LEU A 342ALA A 157SER A 262TYR A 263 | None | 1.38A | 3apvA-1skxA:undetectable | 3apvA-1skxA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t1u | CHOLINEO-ACETYLTRANSFERASE (Rattusnorvegicus) |
PF00755(Carn_acyltransf) | 5 | VAL A 343PHE A 403LEU A 300HIS A 334SER A 550 | None | 1.24A | 3apvA-1t1uA:0.0 | 3apvA-1t1uA:13.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tqy | ACTINORHODINPOLYKETIDE PUTATIVEBETA-KETOACYLSYNTHASE 1 (Streptomycescoelicolor) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | PHE A 235PHE A 208LEU A 237ALA A 107SER A 171 | None | 1.47A | 3apvA-1tqyA:0.0 | 3apvA-1tqyA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tuf | DIAMINOPIMELATEDECARBOXYLASE (Methanocaldococcusjannaschii) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | PHE A 65PHE A 76LEU A 301SER A 308TYR A 61 | NoneNoneNoneLLP A 83 ( 4.7A)None | 1.43A | 3apvA-1tufA:undetectable | 3apvA-1tufA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufo | HYPOTHETICAL PROTEINTT1662 (Thermusthermophilus) |
no annotation | 5 | VAL A 118LEU A 13GLU A 91ARG A 65HIS A 62 | None | 1.39A | 3apvA-1ufoA:undetectable | 3apvA-1ufoA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wou | THIOREDOXIN -RELATEDPROTEIN, 14 KDA (Homo sapiens) |
PF06110(DUF953) | 5 | PHE A 120LEU A 57GLU A 6ARG A 54ALA A 49 | None | 1.13A | 3apvA-1wouA:undetectable | 3apvA-1wouA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zel | HYPOTHETICAL PROTEINRV2827C (Mycobacteriumtuberculosis) |
PF09407(AbiEi_1)PF13338(AbiEi_4) | 5 | VAL A 1PHE A 99LEU A 175ARG A 88ALA A 92 | None | 1.38A | 3apvA-1zelA:undetectable | 3apvA-1zelA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zun | SULFATEADENYLYLTRANSFERASESUBUNIT 2 (Pseudomonassyringae) |
PF01507(PAPS_reduct) | 5 | TYR A 196PHE A 131PHE A 57HIS A 44SER A 15 | None | 1.45A | 3apvA-1zunA:undetectable | 3apvA-1zunA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aex | COPROPORPHYRINOGENIII OXIDASE,MITOCHONDRIAL (Homo sapiens) |
PF01218(Coprogen_oxidas) | 5 | PHE A 339PHE A 353HIS A 297SER A 364TYR A 261 | None | 0.94A | 3apvA-2aexA:undetectable | 3apvA-2aexA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j04 | HYPOTHETICAL PROTEINYPL007C (Saccharomycescerevisiae) |
PF12660(zf-TFIIIC) | 5 | VAL A 552PHE A 454LEU A 455SER A 548SER A 578 | None | 1.47A | 3apvA-2j04A:undetectable | 3apvA-2j04A:14.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x63 | ALPHA-2,3-/2,8-SIALYLTRANSFERASE (Campylobacterjejuni) |
PF06002(CST-I) | 5 | PHE A 178LEU A 171ALA A 51SER A 79SER A 132 | NoneNoneNoneNone C A1261 (-2.8A) | 1.43A | 3apvA-2x63A:undetectable | 3apvA-2x63A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yfn | ALPHA-GALACTOSIDASE-SUCROSE KINASE AGASK ([Ruminococcus]gnavus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 5 | PHE A 556PHE A 195LEU A 193ARG A 207TYR A 552 | None | 1.50A | 3apvA-2yfnA:undetectable | 3apvA-2yfnA:13.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zqp | PREPROTEINTRANSLOCASE SECYSUBUNIT (Thermusthermophilus) |
PF00344(SecY) | 5 | VAL Y 157PHE Y 67PHE Y 56LEU Y 48ALA Y 133 | None | 1.25A | 3apvA-2zqpY:undetectable | 3apvA-2zqpY:15.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3apu | ALPHA-1-ACIDGLYCOPROTEIN 2 (Homo sapiens) |
PF00061(Lipocalin) | 6 | TYR A 37GLU A 64ARG A 90HIS A 97SER A 30TYR A 27 | NonePG4 A 190 (-4.1A)PG4 A 190 (-4.3A)NoneNonePG4 A 190 ( 3.8A) | 1.37A | 3apvA-3apuA:32.7 | 3apvA-3apuA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3apu | ALPHA-1-ACIDGLYCOPROTEIN 2 (Homo sapiens) |
PF00061(Lipocalin) | 6 | TYR A 37PHE A 49LEU A 62HIS A 97ALA A 99SER A 114 | NonePG4 A 190 ( 4.1A)NoneNonePG4 A 190 ( 4.2A)None | 1.48A | 3apvA-3apuA:32.7 | 3apvA-3apuA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3apu | ALPHA-1-ACIDGLYCOPROTEIN 2 (Homo sapiens) |
PF00061(Lipocalin) | 12 | TYR A 37VAL A 41PHE A 49PHE A 51LEU A 62GLU A 64ARG A 90HIS A 97ALA A 99SER A 114SER A 125TYR A 127 | NonePG4 A 190 (-4.9A)PG4 A 190 ( 4.1A)NoneNonePG4 A 190 (-4.1A)PG4 A 190 (-4.3A)NonePG4 A 190 ( 4.2A)NonePG4 A 190 ( 3.7A)None | 0.61A | 3apvA-3apuA:32.7 | 3apvA-3apuA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3att | PUTATIVEUNCHARACTERIZEDPROTEIN (Mycobacteriumtuberculosis) |
PF01636(APH) | 5 | VAL A 244LEU A 326GLU A 277ALA A 250TYR A 315 | None | 1.24A | 3apvA-3attA:undetectable | 3apvA-3attA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fa5 | PROTEIN OF UNKNOWNFUNCTION (DUF849) (Paracoccusdenitrificans) |
PF05853(BKACE) | 5 | VAL A 175LEU A 19SER A 110SER A 112TYR A 123 | None | 1.48A | 3apvA-3fa5A:undetectable | 3apvA-3fa5A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gnr | OS03G0212800 PROTEIN (Oryza sativa) |
PF00232(Glyco_hydro_1) | 5 | PHE A 301LEU A 223GLU A 305ARG A 149TYR A 286 | PHE A 301 ( 1.3A)LEU A 223 ( 0.5A)GLU A 305 ( 0.6A)ARG A 149 ( 0.6A)TYR A 286 ( 1.3A) | 1.44A | 3apvA-3gnrA:undetectable | 3apvA-3gnrA:16.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ho8 | PYRUVATE CARBOXYLASE (Staphylococcusaureus) |
PF00289(Biotin_carb_N)PF00682(HMGL-like)PF02436(PYC_OADA)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | PHE A 598LEU A 604HIS A 771ALA A 573SER A 806 | NoneNone MN A2002 (-3.5A)NoneNone | 1.40A | 3apvA-3ho8A:undetectable | 3apvA-3ho8A:10.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kao | TAGATOSE1,6-DIPHOSPHATEALDOLASE (Staphylococcusaureus) |
PF01791(DeoC) | 5 | VAL A 203PHE A 257LEU A 261ALA A 23SER A 66 | None | 1.46A | 3apvA-3kaoA:undetectable | 3apvA-3kaoA:17.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kq0 | ALPHA-1-ACIDGLYCOPROTEIN 1 (Homo sapiens) |
PF00061(Lipocalin) | 8 | PHE A 49PHE A 51LEU A 62GLU A 64ARG A 90ALA A 99SER A 125TYR A 127 | JIM A 193 (-3.8A)NoneNoneNoneJIM A 193 (-4.3A)JIM A 193 ( 4.0A)NoneNone | 0.80A | 3apvA-3kq0A:27.8 | 3apvA-3kq0A:86.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kq0 | ALPHA-1-ACIDGLYCOPROTEIN 1 (Homo sapiens) |
PF00061(Lipocalin) | 5 | PHE A 51HIS A 97ALA A 99SER A 125TYR A 127 | NoneNoneJIM A 193 ( 4.0A)NoneNone | 0.76A | 3apvA-3kq0A:27.8 | 3apvA-3kq0A:86.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kq0 | ALPHA-1-ACIDGLYCOPROTEIN 1 (Homo sapiens) |
PF00061(Lipocalin) | 5 | PHE A 51LEU A 62ARG A 90ALA A 99TYR A 110 | NoneNoneJIM A 193 (-4.3A)JIM A 193 ( 4.0A)None | 1.46A | 3apvA-3kq0A:27.8 | 3apvA-3kq0A:86.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kq0 | ALPHA-1-ACIDGLYCOPROTEIN 1 (Homo sapiens) |
PF00061(Lipocalin) | 5 | PHE A 51LEU A 79HIS A 97SER A 125TYR A 127 | None | 1.34A | 3apvA-3kq0A:27.8 | 3apvA-3kq0A:86.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kq0 | ALPHA-1-ACIDGLYCOPROTEIN 1 (Homo sapiens) |
PF00061(Lipocalin) | 8 | VAL A 41PHE A 49PHE A 51LEU A 62ARG A 90ALA A 99SER A 125TYR A 127 | NoneJIM A 193 (-3.8A)NoneNoneJIM A 193 (-4.3A)JIM A 193 ( 4.0A)NoneNone | 0.70A | 3apvA-3kq0A:27.8 | 3apvA-3kq0A:86.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mq3 | PYRUVATEDEHYDROGENASEPHOSPHATASE 1 (Bos taurus) |
PF00481(PP2C) | 5 | VAL A 285LEU A 136GLU A 179ARG A 87ALA A 79 | None | 1.42A | 3apvA-3mq3A:undetectable | 3apvA-3mq3A:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oee | ATP SYNTHASE SUBUNITALPHA (Saccharomycescerevisiae) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 5 | VAL A 97LEU A 303ARG A 306ALA A 253SER A 254 | None | 1.04A | 3apvA-3oeeA:undetectable | 3apvA-3oeeA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pao | ADENOSINE DEAMINASE (Pseudomonasaeruginosa) |
PF00962(A_deaminase) | 5 | PHE A 59PHE A 282LEU A 251SER A 138TYR A 63 | NoneNoneNoneNoneADE A 328 (-4.0A) | 1.33A | 3apvA-3paoA:undetectable | 3apvA-3paoA:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ps9 | TRNA5-METHYLAMINOMETHYL-2-THIOURIDINEBIOSYNTHESISBIFUNCTIONAL PROTEINMNMC (Escherichiacoli) |
PF01266(DAO)PF05430(Methyltransf_30) | 5 | TYR A 521PHE A 326LEU A 322ALA A 569SER A 617 | None | 1.10A | 3apvA-3ps9A:undetectable | 3apvA-3ps9A:12.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psf | TRANSCRIPTIONELONGATION FACTORSPT6 (Saccharomycescerevisiae) |
PF14635(HHH_7)PF14639(YqgF)PF14641(HTH_44)PF14878(DLD) | 5 | GLU A 450HIS A 535ALA A 521SER A 520TYR A 472 | None | 1.37A | 3apvA-3psfA:undetectable | 3apvA-3psfA:10.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u7j | RIBOSE-5-PHOSPHATEISOMERASE A (Burkholderiathailandensis) |
PF06026(Rib_5-P_isom_A) | 5 | PHE A 121PHE A 211ALA A 107SER A 61TYR A 87 | NoneNone K A 238 (-4.2A)NoneNone | 1.43A | 3apvA-3u7jA:undetectable | 3apvA-3u7jA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uwq | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Vibrio cholerae) |
PF00215(OMPdecase) | 5 | LEU A 165GLU A 161HIS A 139ALA A 89SER A 90 | None | 1.49A | 3apvA-3uwqA:undetectable | 3apvA-3uwqA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w3e | COTYLEDONEOUSYIELDIN-LIKE PROTEIN (Vignaunguiculata) |
PF00182(Glyco_hydro_19) | 5 | VAL A 88PHE A 61LEU A 62ALA A 34SER A 149 | None | 1.34A | 3apvA-3w3eA:undetectable | 3apvA-3w3eA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eog | PUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF09455(Cas_DxTHG) | 5 | TYR A 459PHE A 341LEU A 351ALA A 258SER A 259 | None | 1.49A | 3apvA-4eogA:undetectable | 3apvA-4eogA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f7a | PUTATIVEUNCHARACTERIZEDPROTEIN (Bacteroidesvulgatus) |
PF12741(SusD-like) | 5 | TYR A 181LEU A 358GLU A 149ARG A 232ALA A 234 | None | 1.46A | 3apvA-4f7aA:undetectable | 3apvA-4f7aA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fk8 | FERREDOXIN--NADPREDUCTASE (Burkholderiathailandensis) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | PHE A 82LEU A 34GLU A 164ALA A 268SER A 129 | None | 1.34A | 3apvA-4fk8A:undetectable | 3apvA-4fk8A:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fs3 | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE[NADPH] FABI (Staphylococcusaureus) |
PF13561(adh_short_C2) | 5 | VAL A 154PHE A 204LEU A 208ALA A 190SER A 189 | NoneNoneNone0WD A 301 (-3.5A)None | 1.41A | 3apvA-4fs3A:undetectable | 3apvA-4fs3A:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4goj | PROTEIN UNC-119HOMOLOG A (Homo sapiens) |
PF05351(GMP_PDE_delta) | 5 | PHE C 159PHE C 149HIS C 192SER C 218TYR C 220 | None | 1.45A | 3apvA-4gojC:undetectable | 3apvA-4gojC:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9t | DESIGNED UNNATURALAMINO ACID DEPENDENTMETALLOPROTEIN (Micromonosporaviridifaciens) |
PF13088(BNR_2) | 5 | TYR A 370LEU A 170HIS A 69ALA A 205SER A 259 | None | 1.43A | 3apvA-4j9tA:undetectable | 3apvA-4j9tA:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0r | CRYPTOCHROME-1 (Mus musculus) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 5 | LEU A 385ARG A 358HIS A 354ALA A 246SER A 247 | None | 1.19A | 3apvA-4k0rA:undetectable | 3apvA-4k0rA:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rqo | L-SERINE DEHYDRATASE (Legionellapneumophila) |
PF03313(SDH_alpha)PF03315(SDH_beta) | 5 | TYR A 330VAL A 428LEU A 180ALA A 356SER A 352 | None | 1.44A | 3apvA-4rqoA:undetectable | 3apvA-4rqoA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tm3 | KTZI (Kutzneria sp.744) |
PF13434(K_oxygenase) | 5 | TYR A 346LEU A 56GLU A 212ARG A 104HIS A 51 | FAD A 501 ( 4.3A)NoneNoneFAD A 501 ( 4.2A)FAD A 501 (-3.7A) | 1.39A | 3apvA-4tm3A:undetectable | 3apvA-4tm3A:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tx7 | CLASS I CHITINASE (Vignaunguiculata) |
PF00182(Glyco_hydro_19) | 5 | VAL A 132PHE A 105LEU A 106ALA A 78SER A 194 | None | 1.34A | 3apvA-4tx7A:undetectable | 3apvA-4tx7A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4um8 | INTEGRIN ALPHA-VINTEGRIN BETA-6 (Homo sapiens) |
PF00362(Integrin_beta)PF01839(FG-GAP)PF08441(Integrin_alpha2)PF17205(PSI_integrin) | 5 | PHE A 427GLU B 291ARG A 339ALA A 343SER A 279 | NoneNoneSO4 A1597 ( 4.8A)NoneNone | 1.44A | 3apvA-4um8A:undetectable | 3apvA-4um8A:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4woy | MITOCHONDRIALDYNAMICS PROTEINMID49 (Mus musculus) |
PF03281(Mab-21) | 5 | PHE A 173LEU A 171GLU A 170ALA A 261SER A 265 | None | 1.47A | 3apvA-4woyA:undetectable | 3apvA-4woyA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y9v | PARTICLE-ASSOCIATEDLYASE (Acinetobactervirus AP22) |
no annotation | 5 | VAL A 176PHE A 216PHE A 208LEU A 318HIS A 180 | EDO A 808 ( 3.6A)NoneNoneNoneEDO A 805 (-4.6A) | 1.37A | 3apvA-4y9vA:undetectable | 3apvA-4y9vA:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ejj | UFM1-SPECIFICPROTEASE (Caenorhabditiselegans) |
PF07910(Peptidase_C78) | 5 | VAL A 133PHE A 128PHE A 104LEU A 106HIS A 59 | None | 1.27A | 3apvA-5ejjA:undetectable | 3apvA-5ejjA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eov | 16S/23S RRNA(CYTIDINE-2'-O)-METHYLTRANSFERASE TLYA (Mycobacteriumtuberculosis) |
PF01728(FtsJ) | 5 | PHE A 240LEU A 180GLU A 238ALA A 67SER A 64 | None | 1.42A | 3apvA-5eovA:undetectable | 3apvA-5eovA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5u | BETA-HEXOSAMINIDASE (Pseudomonasaeruginosa) |
PF00933(Glyco_hydro_3) | 5 | TYR A 212VAL A 215LEU A 235GLU A 234SER A 223 | None | 1.29A | 3apvA-5g5uA:undetectable | 3apvA-5g5uA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 5 | VAL A 308PHE A 14PHE A 18LEU A 13ALA A 314 | None | 1.42A | 3apvA-5gnmA:undetectable | 3apvA-5gnmA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hjr | NEUTRALALPHA-GLUCOSIDASE AB (Mus musculus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 5 | LEU A 304GLU A 575ARG A 300ALA A 341SER A 381 | EDO A1005 (-3.8A)EDO A1005 ( 4.9A)EDO A1005 (-4.1A)NoneNone | 1.22A | 3apvA-5hjrA:undetectable | 3apvA-5hjrA:12.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvf | SITE-DETERMININGPROTEIN (Pseudomonasaeruginosa) |
PF10609(ParA) | 5 | VAL A 79PHE A 114PHE A 266LEU A 124ALA A 47 | None | 1.28A | 3apvA-5jvfA:undetectable | 3apvA-5jvfA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jvf | SITE-DETERMININGPROTEIN (Pseudomonasaeruginosa) |
PF10609(ParA) | 5 | VAL A 146PHE A 266PHE A 114LEU A 270ALA A 47 | None | 1.47A | 3apvA-5jvfA:undetectable | 3apvA-5jvfA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l7v | GLYCOSIDE HYDROLASE (Bacteroidesvulgatus) |
PF13320(DUF4091) | 5 | VAL A 243PHE A 282PHE A 343LEU A 347SER A 385 | None | 1.42A | 3apvA-5l7vA:undetectable | 3apvA-5l7vA:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n1q | METHYL-COENZYME MREDUCTASE III FROMMETHANOTHERMOCOCCUSTHERMOLITHOTROPHICUSSUBUNIT BETA (Methanothermococcusthermolithotrophicus) |
PF02241(MCR_beta)PF02783(MCR_beta_N) | 5 | TYR B 127PHE B 425PHE B 214SER B 177TYR B 419 | None | 1.50A | 3apvA-5n1qB:undetectable | 3apvA-5n1qB:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnn | CTATC (Chaetomiumthermophilum) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | PHE A1950LEU A2247HIS A2081ALA A2085SER A2118 | None | 1.31A | 3apvA-5nnnA:undetectable | 3apvA-5nnnA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nnn | CTATC (Chaetomiumthermophilum) |
PF00185(OTCace)PF02729(OTCace_N) | 5 | PHE A1950LEU A2247HIS A2081ALA A2085SER A2118 | None | 1.45A | 3apvA-5nnnA:undetectable | 3apvA-5nnnA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nno | ALDEHYDEDEHYDROGENASE (Trypanosomabrucei) |
PF00171(Aldedh) | 5 | PHE A 291LEU A 292GLU A 339ARG A 283ALA A 255 | None | 1.19A | 3apvA-5nnoA:undetectable | 3apvA-5nnoA:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ocs | PUTATIVENADH-DEPENTDENTFLAVINOXIDOREDUCTASE (Cupriavidusmetallidurans) |
PF00724(Oxidored_FMN) | 5 | VAL A 89LEU A 13GLU A 173ALA A 50SER A 48 | None | 0.94A | 3apvA-5ocsA:undetectable | 3apvA-5ocsA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2l | HEAT SHOCK PROTEIN104 (Candidaalbicans) |
PF02861(Clp_N) | 5 | VAL A 93PHE A 128PHE A 63HIS A 31ALA A 35 | None | 1.14A | 3apvA-5u2lA:undetectable | 3apvA-5u2lA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xep | CHITINASE-3-LIKEPROTEIN 1 (Mus musculus) |
no annotation | 5 | TYR A 27VAL A 25ALA A 139SER A 96SER A 176 | None | 1.47A | 3apvA-5xepA:undetectable | 3apvA-5xepA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwb | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Colwelliapsychrerythraea) |
PF00275(EPSP_synthase) | 5 | PHE A 414LEU A 18ALA A 253SER A 393TYR A 417 | None | 1.42A | 3apvA-5xwbA:undetectable | 3apvA-5xwbA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yq7 | PRECURSOR FOR MSUBUNITS OFPHOTOSYNTHETICREACTION CENTER (Roseiflexuscastenholzii) |
no annotation | 5 | PHE M 481LEU M 485HIS M 500SER M 389SER M 448 | None | 1.49A | 3apvA-5yq7M:undetectable | 3apvA-5yq7M:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b2y | SOLUTE-BINDINGPERIPLASMIC PROTEINOF IRON/SIDEROPHOREABC TRANSPORTER (Yersinia pestis) |
no annotation | 5 | PHE A 28PHE A 50ALA A 257SER A 339TYR A 61 | NoneNoneNoneNone NA A 401 (-4.3A) | 1.19A | 3apvA-6b2yA:undetectable | 3apvA-6b2yA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cpy | GRMZM2G135359PSEUDOKINASE (Zea mays) |
no annotation | 5 | PHE A 357LEU A 354HIS A 284ALA A 370TYR A 405 | None | 1.41A | 3apvA-6cpyA:undetectable | 3apvA-6cpyA:16.97 |