SIMILAR PATTERNS OF AMINO ACIDS FOR 3ADX_A_IMNA2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 PHE A 403
SER A 271
HIS A 263
PHE A 406
TYR A 294
 None
None
None
CDU  A1100 (-4.6A)
None
 1.32A 3adxA-1ek2A:
undetectable		 3adxA-1ek2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		5 GLN A 167
SER A 166
LEU A  60
LEU B 344
TYR B 341
 None
 1.30A 3adxA-1gxsA:
undetectable		 3adxA-1gxsA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 PHE A 127
HIS A 149
LEU A 159
LEU A  29
TYR A  33
 None
 1.26A 3adxA-1qe0A:
0.0		 3adxA-1qe0A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 PHE A 127
HIS A 149
LEU A 159
PHE A 306
TYR A  33
 None
 1.36A 3adxA-1qe0A:
0.0		 3adxA-1qe0A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmy PROTEASE

(Foot-and-mouth
disease virus) 		PF05408
(Peptidase_C28) 		5 PHE A  68
GLN A  85
HIS A 109
PHE A  60
LEU A  89
 None
 1.33A 3adxA-1qmyA:
undetectable		 3adxA-1qmyA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 GLN A 465
SER A 468
LEU A 520
LEU A 331
LEU A 496
 None
 1.40A 3adxA-1x9nA:
0.0		 3adxA-1x9nA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1v STE50 PROTEIN

(Saccharomyces
cerevisiae) 		PF09235
(Ste50p-SAM) 		5 CYH A  78
GLN A  79
LEU A  48
LEU A  70
LEU A  86
 None
 1.50A 3adxA-1z1vA:
undetectable		 3adxA-1z1vA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		5 TYR A 362
LEU A 364
LEU A 257
HIS A 245
LEU A 388
 None
 1.29A 3adxA-1zzgA:
undetectable		 3adxA-1zzgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		5 CYH A 357
GLN A 358
SER A 361
LEU A 389
LEU A 372
 None
 1.46A 3adxA-2bnhA:
undetectable		 3adxA-2bnhA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN

(Escherichia
coli) 		PF05472
(Ter) 		5 GLN A  19
HIS A 116
LEU A 159
LEU A  71
HIS A 113
 None
 1.45A 3adxA-2i05A:
0.0		 3adxA-2i05A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 GLN A 276
SER A 416
LEU A 175
LEU A 222
HIS A 217
 None
 1.49A 3adxA-2i0kA:
undetectable		 3adxA-2i0kA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 CYH A1316
GLN A1315
HIS A1350
LEU A1361
TYR A1262
 None
 1.05A 3adxA-2nlkA:
undetectable		 3adxA-2nlkA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 CYH A1316
HIS A1350
LEU A1285
HIS A1313
TYR A1262
 None
 1.47A 3adxA-2nlkA:
undetectable		 3adxA-2nlkA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 PHE A 273
CYH A 276
GLN A 277
LEU A 321
LEU A 344
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.89A 3adxA-2p54A:
37.2		 3adxA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 PHE A 273
GLN A 277
SER A 280
LEU A 321
LEU A 344
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-4.4A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 ( 4.2A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.66A 3adxA-2p54A:
37.2		 3adxA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzx G-PROTEIN COUPLED
RECEPTOR MTH

(Drosophila
melanogaster) 		PF06652
(Methuselah_N) 		5 PHE A 144
LEU A 132
LEU A 158
PHE A 150
HIS A 152
 None
 1.42A 3adxA-2pzxA:
undetectable		 3adxA-2pzxA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		5 GLN A 712
SER A 764
LEU A 739
LEU A 697
TYR A 757
 None
 1.48A 3adxA-2qnaA:
undetectable		 3adxA-2qnaA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qx2 SEX PHEROMONE
STAPH-CAM373

(Staphylococcus
aureus) 		PF07537
(CamS) 		5 PHE A 173
GLN A 171
LEU A 229
HIS A 244
LEU A  86
 None
 1.47A 3adxA-2qx2A:
undetectable		 3adxA-2qx2A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01128
(IspD) 		5 SER A 112
HIS A 178
LEU A 184
LEU A 291
LEU A  83
 None
 1.37A 3adxA-2ycmA:
undetectable		 3adxA-2ycmA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 CYH A 285
GLN A 286
HIS A 323
TYR A 327
LEU A 330
LEU A 353
HIS A 449
LEU A 469
TYR A 473
 MC5  A   1 (-3.6A)
None
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.66A 3adxA-3b0qA:
41.4		 3adxA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 285
GLN A 286
LEU A 356
HIS A 449
LEU A 469
TYR A 473
 MC5  A   1 (-3.6A)
None
None
MC5  A   1 (-3.9A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 1.39A 3adxA-3b0qA:
41.4		 3adxA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 GLN A 286
SER A 289
HIS A 323
TYR A 327
LEU A 330
LEU A 353
HIS A 449
LEU A 469
TYR A 473
 None
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.69A 3adxA-3b0qA:
41.4		 3adxA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
CYH A 285
GLN A 286
HIS A 323
LEU A 469
TYR A 473
 MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
None
MC5  A   1 (-3.8A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 1.07A 3adxA-3b0qA:
41.4		 3adxA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
GLN A 286
SER A 289
HIS A 323
LEU A 469
TYR A 473
 MC5  A   1 (-4.4A)
None
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.89A 3adxA-3b0qA:
41.4		 3adxA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		5 PHE A  91
GLN A 111
SER A 110
LEU A 147
LEU A  76
 None
 1.11A 3adxA-3czpA:
undetectable		 3adxA-3czpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		5 PHE A  91
GLN A 111
SER A 110
PHE A 104
LEU A  76
 None
 1.26A 3adxA-3czpA:
undetectable		 3adxA-3czpA:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 CYH A 285
GLN A 286
LEU A 353
PHE A 360
LEU A 469
 L41  A 501 (-3.5A)
None
None
None
L41  A 501 (-3.8A)
 1.33A 3adxA-3d5fA:
36.3		 3adxA-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 PHE A 282
CYH A 285
GLN A 286
HIS A 323
LEU A 330
LEU A 353
HIS A 449
LEU A 469
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
None
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
None
L41  A 501 (-3.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.84A 3adxA-3d5fA:
36.3		 3adxA-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 CYH D 285
GLN D 286
SER D 289
LEU D 330
LEU D 353
PHE D 363
LEU D 469
 PLB  D 701 (-3.2A)
None
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
None
None
None
 0.79A 3adxA-3dzuD:
37.0		 3adxA-3dzuD:
94.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 CYH D 285
GLN D 286
SER D 289
TYR D 327
LEU D 330
LEU D 353
HIS D 449
LEU D 469
 PLB  D 701 (-3.2A)
None
PLB  D 701 ( 3.9A)
None
PLB  D 701 ( 4.1A)
None
None
None
 0.74A 3adxA-3dzuD:
37.0		 3adxA-3dzuD:
94.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 CYH D 285
HIS D 323
TYR D 327
HIS D 449
TYR D 473
 PLB  D 701 (-3.2A)
None
None
None
None
 1.26A 3adxA-3dzuD:
37.0		 3adxA-3dzuD:
94.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 CYH D 285
SER D 289
LEU D 330
LEU D 353
PHE D 363
LEU D 469
TYR D 473
 PLB  D 701 (-3.2A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
None
None
None
None
 0.68A 3adxA-3dzuD:
37.0		 3adxA-3dzuD:
94.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 CYH D 285
SER D 289
TYR D 327
LEU D 330
LEU D 353
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 (-3.2A)
PLB  D 701 ( 3.9A)
None
PLB  D 701 ( 4.1A)
None
None
None
None
 0.78A 3adxA-3dzuD:
37.0		 3adxA-3dzuD:
94.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 PHE D 282
GLN D 286
SER D 289
LEU D 353
PHE D 363
LEU D 469
 None
None
PLB  D 701 ( 3.9A)
None
None
None
 1.03A 3adxA-3dzuD:
37.0		 3adxA-3dzuD:
94.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 PHE D 282
GLN D 286
SER D 289
TYR D 327
LEU D 353
HIS D 449
LEU D 469
 None
None
PLB  D 701 ( 3.9A)
None
None
None
None
 0.84A 3adxA-3dzuD:
37.0		 3adxA-3dzuD:
94.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		5 CYH A 248
SER A 256
LEU A 214
LEU A 148
PHE A 141
 None
 1.35A 3adxA-3i4xA:
undetectable		 3adxA-3i4xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if2 AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00155
(Aminotran_1_2) 		5 SER A 395
TYR A 188
LEU A 356
HIS A 409
TYR A 407
 None
 1.38A 3adxA-3if2A:
undetectable		 3adxA-3if2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k25 SLR1438 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF01263
(Aldose_epim) 		5 GLN A 147
LEU A  34
LEU A  25
PHE A 284
LEU A 161
 None
 1.30A 3adxA-3k25A:
undetectable		 3adxA-3k25A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr7 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Streptococcus
mutans) 		PF01070
(FMN_dh) 		5 PHE A  53
LEU A 248
LEU A 263
PHE A  55
LEU A 112
 None
 1.35A 3adxA-3sr7A:
undetectable		 3adxA-3sr7A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 CYH A 232
LEU A 201
LEU A 105
LEU A 244
TYR A 254
 None
 1.46A 3adxA-3vueA:
undetectable		 3adxA-3vueA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi3 SSP1

(Serratia
marcescens) 		PF14113
(Tae4) 		5 PHE A 123
TYR A   5
LEU A 162
LEU A  92
LEU A 144
 None
 1.37A 3adxA-4bi3A:
undetectable		 3adxA-4bi3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		5 PHE A 493
TYR A 548
LEU A 551
LEU A 536
LEU A 459
 None
 1.40A 3adxA-4d72A:
undetectable		 3adxA-4d72A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exl PHOSPHATE-BINDING
PROTEIN PSTS 1

(Streptococcus
pneumoniae) 		PF12849
(PBP_like_2) 		5 SER A  68
LEU A 110
HIS A 236
LEU A  72
TYR A 238
 None
 1.49A 3adxA-4exlA:
undetectable		 3adxA-4exlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB

(Acinetobacter
baumannii) 		PF01636
(APH) 		5 GLN A 227
TYR A 251
LEU A 247
LEU A 204
HIS A 132
 None
 1.24A 3adxA-4gkhA:
undetectable		 3adxA-4gkhA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgc BILE ACID-COENZYME A
LIGASE

([Clostridium]
scindens) 		PF00501
(AMP-binding) 		5 PHE A 264
GLN A 217
LEU A 275
LEU A 311
LEU A 219
 None
 1.43A 3adxA-4lgcA:
undetectable		 3adxA-4lgcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		5 PHE A 246
CYH A 243
GLN A 245
LEU A 231
LEU A 194
 None
 1.30A 3adxA-4lmvA:
undetectable		 3adxA-4lmvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 PHE A 154
GLN A 206
TYR A 139
LEU A 140
TYR A  36
 None
 1.33A 3adxA-4lz6A:
2.2		 3adxA-4lz6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n02 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Streptococcus
pneumoniae) 		PF01070
(FMN_dh) 		5 PHE A  54
LEU A 249
LEU A 264
PHE A  56
LEU A 113
 SO4  A 401 (-4.6A)
None
None
None
None
 1.34A 3adxA-4n02A:
undetectable		 3adxA-4n02A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pde PROTEIN FDHD

(Escherichia
coli) 		PF02634
(FdhD-NarQ) 		5 SER A 228
LEU A 198
LEU A 157
PHE A 237
LEU A 255
 None
 1.40A 3adxA-4pdeA:
undetectable		 3adxA-4pdeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLN A 111
SER A 112
TYR A 120
LEU A  56
LEU A 239
 None
GOL  A 401 (-3.6A)
None
None
None
 1.33A 3adxA-5hc4A:
undetectable		 3adxA-5hc4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 SER A 112
HIS A 106
TYR A 120
LEU A  56
LEU A 239
 GOL  A 401 (-3.6A)
None
None
None
None
 1.23A 3adxA-5hc4A:
undetectable		 3adxA-5hc4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmd HEPARINASE III
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		5 PHE A 210
LEU A 203
PHE A 262
LEU A  59
TYR A  62
 None
 1.31A 3adxA-5jmdA:
undetectable		 3adxA-5jmdA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 5 PHE A 248
TYR A 307
LEU A 239
LEU A 174
TYR A 175
 None
GOL  A 504 (-3.3A)
None
None
GOL  A 504 (-4.4A)
 1.37A 3adxA-5ns8A:
undetectable		 3adxA-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 TYR A 385
LEU A 338
PHE A 334
HIS A 292
LEU A 133
 None
 1.49A 3adxA-5um6A:
undetectable		 3adxA-5um6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6) 		5 GLN D 281
HIS D 402
TYR D 413
HIS C 123
TYR D 279
 None
 1.34A 3adxA-5xfaD:
undetectable		 3adxA-5xfaD:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 5 GLN A 307
LEU A 259
LEU A 281
PHE A 272
HIS A 273
 None
 1.20A 3adxA-6cc2A:
undetectable		 3adxA-6cc2A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens) 		PF00191
(Annexin) 		4 ILE A  28
ILE A 314
LEU A  69
MET A  85
 None
 0.94A 3adxA-1axnA:
undetectable		 3adxA-1axnA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg4 ENDO-1,4-BETA-XYLANA
SE

(Penicillium
simplicissimum) 		PF00331
(Glyco_hydro_10) 		5 ILE A 133
ILE A 234
LEU A 140
MET A 188
LEU A 196
 NA  A 622 ( 4.4A)
None
None
None
None
 1.40A 3adxA-1bg4A:
0.0		 3adxA-1bg4A:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu2 CYCLIN HOMOLOG

(Saimiriine
gammaherpesvirus
2) 		PF00134
(Cyclin_N)
PF09241
(Herp-Cyclin) 		4 ILE A  79
ILE A 198
LEU A 143
LEU A  40
 None
 0.98A 3adxA-1bu2A:
0.0		 3adxA-1bu2A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		5 ILE L 604
LEU L 672
PHE L 673
MET L 583
LEU L 520
 None
 1.23A 3adxA-1kfuL:
0.0		 3adxA-1kfuL:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 ILE A 154
ILE A 242
LEU A 139
LEU A 128
 None
 0.80A 3adxA-1kl7A:
undetectable		 3adxA-1kl7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ls4 APOLIPOPHORIN-III

(Locusta
migratoria) 		no annotation 4 ILE A 118
ILE A  21
LEU A  77
PHE A  80
 None
 0.78A 3adxA-1ls4A:
undetectable		 3adxA-1ls4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mwo ALPHA AMYLASE

(Pyrococcus
woesei) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 ILE A  30
ILE A 327
LEU A  47
MET A  13
 None
 0.98A 3adxA-1mwoA:
undetectable		 3adxA-1mwoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1c TORA SPECIFIC
CHAPERONE

(Shewanella
massilia) 		PF02613
(Nitrate_red_del) 		4 ILE A 198
ILE A 171
LEU A 156
LEU A 140
 None
 0.98A 3adxA-1n1cA:
0.0		 3adxA-1n1cA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		4 ILE A 605
ILE A 473
LEU A 638
PHE A 580
 None
 0.93A 3adxA-1qafA:
undetectable		 3adxA-1qafA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3g ADENYLATE KINASE

(Sporosarcina
globispora) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 ILE A 107
ILE A 195
LEU A  96
LEU A 183
 None
 0.93A 3adxA-1s3gA:
undetectable		 3adxA-1s3gA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td6 HYPOTHETICAL PROTEIN
MG237 HOMOLOG

(Mycoplasma
pneumoniae) 		PF11428
(DUF3196) 		4 ILE A 197
LEU A 236
PHE A   8
LEU A  71
 None
 0.95A 3adxA-1td6A:
undetectable		 3adxA-1td6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 ILE A 422
ILE A 463
LEU A 477
LEU A  33
 None
 0.89A 3adxA-1tz7A:
undetectable		 3adxA-1tz7A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		4 ILE C 374
ILE C 408
LEU C 751
LEU C 678
 None
 0.84A 3adxA-1w36C:
undetectable		 3adxA-1w36C:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		4 ILE 1 212
LEU 1 204
MET 1 191
LEU 1 250
 None
 0.88A 3adxA-1wao1:
undetectable		 3adxA-1wao1:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 ILE A  82
ILE A  91
LEU A  56
LEU A 123
 None
 0.95A 3adxA-1xecA:
undetectable		 3adxA-1xecA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgy MGC11102 PROTEIN

(Homo sapiens) 		PF01176
(eIF-1a) 		4 ILE A  27
LEU A  88
PHE A  68
LEU A  31
 None
 0.74A 3adxA-2dgyA:
undetectable		 3adxA-2dgyA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 ILE A 243
ILE A 297
LEU A 247
LEU A 168
 None
 0.87A 3adxA-2dh4A:
2.0		 3adxA-2dh4A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmy HYPOTHETICAL PROTEIN
ATU0492

(Agrobacterium
fabrum) 		PF02627
(CMD) 		4 ILE A 123
ILE A  45
LEU A  30
PHE A  34
 None
 0.90A 3adxA-2gmyA:
undetectable		 3adxA-2gmyA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 ILE A 436
ILE A 345
LEU A 168
LEU A 408
 None
 0.95A 3adxA-2h21A:
undetectable		 3adxA-2h21A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk3 DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Staphylococcus
aureus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ILE A  34
LEU A 167
PHE A 150
LEU A  38
 None
 0.84A 3adxA-2hk3A:
undetectable		 3adxA-2hk3A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id0 EXORIBONUCLEASE 2

(Escherichia
coli) 		PF00575
(S1)
PF00773
(RNB)
PF08206
(OB_RNB) 		4 ILE A  60
LEU A 137
MET A  51
LEU A 106
 None
 0.98A 3adxA-2id0A:
undetectable		 3adxA-2id0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 ILE A 259
ILE A 270
LEU A  43
MET A  36
 None
 0.98A 3adxA-2nrjA:
undetectable		 3adxA-2nrjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 ILE A 144
ILE A 188
LEU A 133
MET A 230
 None
 0.98A 3adxA-2ocaA:
undetectable		 3adxA-2ocaA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 272
ILE A 317
LEU A 347
PHE A 351
MET A 355
LYS A 358
 735  A 469 ( 4.2A)
735  A 469 ( 4.8A)
None
None
735  A 469 (-2.9A)
None
 0.40A 3adxA-2p54A:
37.2		 3adxA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		4 ILE A 356
ILE A 320
LEU A 444
LEU A 411
 CL  A   2 ( 4.9A)
None
None
None
 0.78A 3adxA-2r9hA:
undetectable		 3adxA-2r9hA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE

(Escherichia
coli) 		PF01266
(DAO) 		4 ILE A   8
ILE A 152
LEU A 207
LEU A 335
 None
None
FAD  A1373 (-3.9A)
FAD  A1373 ( 3.8A)
 0.92A 3adxA-2uzzA:
undetectable		 3adxA-2uzzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpt LIPOLYTIC ENZYME

(Ruminiclostridium
thermocellum) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 217
ILE A  38
LEU A 209
LEU A  85
 None
 0.78A 3adxA-2vptA:
undetectable		 3adxA-2vptA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xbz RETS-HYBRID SENSOR
KINASE

(Pseudomonas
aeruginosa) 		PF07696
(7TMR-DISMED2) 		4 ILE A  62
ILE A 106
LEU A  66
LEU A  52
 None
 0.95A 3adxA-2xbzA:
undetectable		 3adxA-2xbzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		4 ILE A 169
LEU A 199
PHE A 168
MET A 122
 None
 0.86A 3adxA-2yg6A:
undetectable		 3adxA-2yg6A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxb COENZYME
B12-DEPENDENT MUTASE

(Aeropyrum
pernix) 		PF02310
(B12-binding) 		4 ILE A  75
ILE A 111
LEU A  95
MET A  88
 None
 0.83A 3adxA-2yxbA:
undetectable		 3adxA-2yxbA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
fragi) 		PF13561
(adh_short_C2) 		4 ILE A 137
ILE A  31
LEU A 126
LEU A  73
 None
 0.89A 3adxA-2ztuA:
undetectable		 3adxA-2ztuA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 281
ILE A 326
LEU A 356
MET A 364
LYS A 367
LEU A 453
 MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.9A)
None
MC5  A   1 (-3.7A)
None
MC5  A   1 (-4.2A)
 0.52A 3adxA-3b0qA:
41.4		 3adxA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ILE A 281
ILE A 326
LEU A 356
PHE A 360
MET A 364
LYS A 367
 MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.9A)
None
None
MC5  A   1 (-3.7A)
None
 0.33A 3adxA-3b0qA:
41.4		 3adxA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens) 		PF01875
(Memo) 		4 ILE A  45
ILE A 243
LEU A 183
LEU A 253
 None
 0.88A 3adxA-3bczA:
undetectable		 3adxA-3bczA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ILE A 355
ILE A  16
LEU A 130
MET A  59
 None
 0.90A 3adxA-3be7A:
undetectable		 3adxA-3be7A:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ILE A 326
LEU A 356
PHE A 360
LYS A 367
 None
 0.52A 3adxA-3d5fA:
36.3		 3adxA-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 ILE D 281
ILE D 326
LEU D 356
PHE D 360
MET D 364
 PLB  D 701 (-4.6A)
PLB  D 701 ( 4.5A)
None
None
PLB  D 701 ( 4.8A)
 0.51A 3adxA-3dzuD:
37.0		 3adxA-3dzuD:
94.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 ILE D 281
LEU D 356
PHE D 360
MET D 364
LYS D 367
 PLB  D 701 (-4.6A)
None
None
PLB  D 701 ( 4.8A)
None
 1.09A 3adxA-3dzuD:
37.0		 3adxA-3dzuD:
94.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3feo MBT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02820
(MBT) 		4 ILE A 209
LEU A 188
PHE A 200
LEU A 374
 None
 0.88A 3adxA-3feoA:
undetectable		 3adxA-3feoA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  37
LEU A 362
PHE A 359
LEU A 346
 None
 0.86A 3adxA-3fxgA:
undetectable		 3adxA-3fxgA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goh ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Shewanella
oneidensis) 		PF08240
(ADH_N) 		4 ILE A  38
ILE A 283
LEU A 312
LEU A 111
 None
 0.96A 3adxA-3gohA:
undetectable		 3adxA-3gohA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 212
ILE A 235
LEU A 216
LEU A 270
 None
 0.89A 3adxA-3gp0A:
undetectable		 3adxA-3gp0A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0h PHIKZ029

(Pseudomonas
virus phiKZ) 		no annotation 4 ILE A 365
ILE A 355
LEU A 157
LEU A 175
 None
 0.95A 3adxA-3j0hA:
undetectable		 3adxA-3j0hA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfl METHIONYL-TRNA
SYNTHETASE

(Leishmania
major) 		PF09334
(tRNA-synt_1g) 		5 ILE A 713
ILE A 692
LEU A 710
PHE A 711
LEU A 643
 None
 1.30A 3adxA-3kflA:
undetectable		 3adxA-3kflA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  54
ILE A 301
LEU A  23
LEU A  15
 TYR  A 356 (-4.5A)
None
None
None
 0.97A 3adxA-3kumA:
undetectable		 3adxA-3kumA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 ILE A 952
LEU A 960
PHE A 961
LEU A 845
 None
 0.81A 3adxA-3nzuA:
undetectable		 3adxA-3nzuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe5 UNCHARACTERIZED
PROTEIN

([Clostridium]
leptum) 		PF03816
(LytR_cpsA_psr) 		4 ILE A 136
ILE A 177
LEU A 143
LEU A 354
 None
 0.81A 3adxA-3pe5A:
undetectable		 3adxA-3pe5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhd LACTALDEHYDE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF00171
(Aldedh) 		4 ILE A 287
LEU A 256
PHE A 291
LEU A 341
 None
 0.98A 3adxA-3rhdA:
undetectable		 3adxA-3rhdA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 ILE M  83
ILE M 346
LEU M   3
LEU M  40
 None
 0.96A 3adxA-3rkoM:
undetectable		 3adxA-3rkoM:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		4 ILE A 849
ILE A 903
LEU A 873
LEU A 812
 None
 0.74A 3adxA-3s51A:
undetectable		 3adxA-3s51A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13306
(LRR_5) 		4 ILE A 308
ILE A 253
LEU A 345
LEU A 295
 None
None
None
GOL  A 354 (-3.9A)
 0.89A 3adxA-3sb4A:
undetectable		 3adxA-3sb4A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1s UBIQUITIN-LIKE
PROTEIN ATG12

(Saccharomyces
cerevisiae) 		PF04110
(APG12) 		4 ILE C 106
ILE C 111
PHE C 136
LEU C 141
 None
 0.95A 3adxA-3w1sC:
undetectable		 3adxA-3w1sC:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 ILE A 357
ILE A 237
LEU A 359
LEU A 228
 None
 0.85A 3adxA-4az7A:
undetectable		 3adxA-4az7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ILE C 321
ILE C   7
LEU C 311
LEU C  96
 None
 0.96A 3adxA-4b3iC:
undetectable		 3adxA-4b3iC:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 ILE A 919
LEU A 927
PHE A 928
LEU A 811
 None
 0.94A 3adxA-4bfrA:
undetectable		 3adxA-4bfrA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		4 ILE A 368
ILE A 404
LEU A 348
LEU A 342
 None
 0.82A 3adxA-4ccdA:
undetectable		 3adxA-4ccdA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE

(Azoarcus sp.
BH72) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A  95
ILE A 398
MET A 432
LEU A 417
 None
FAD  A1588 (-4.6A)
None
None
 0.93A 3adxA-4d5gA:
undetectable		 3adxA-4d5gA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4w DNA MISMATCH REPAIR
PROTEIN PMS1

(Saccharomyces
cerevisiae) 		PF08676
(MutL_C) 		4 ILE B 686
ILE B 821
LEU B 858
LEU B 839
 None
 0.79A 3adxA-4e4wB:
undetectable		 3adxA-4e4wB:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
caccae) 		PF07523
(Big_3)
PF13306
(LRR_5) 		4 ILE A 258
ILE A 318
LEU A 255
LEU A 329
 None
 0.56A 3adxA-4fd0A:
undetectable		 3adxA-4fd0A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		4 ILE A 258
ILE A 318
LEU A 255
LEU A 329
 None
 0.61A 3adxA-4fdwA:
undetectable		 3adxA-4fdwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gak ACYL-ACP
THIOESTERASE

(Spirosoma
linguale) 		PF01643
(Acyl-ACP_TE) 		4 ILE A 200
LEU A 202
PHE A  61
LEU A 139
 None
 0.96A 3adxA-4gakA:
undetectable		 3adxA-4gakA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 ILE A  21
ILE A 390
LEU A 173
LEU A 147
 None
 0.95A 3adxA-4ghkA:
undetectable		 3adxA-4ghkA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		4 ILE A  43
ILE A  18
LEU A 271
LEU A 204
 None
 0.87A 3adxA-4hesA:
undetectable		 3adxA-4hesA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ILE A 555
LEU A 725
PHE A 649
LEU A 644
 None
 0.93A 3adxA-4knhA:
undetectable		 3adxA-4knhA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lkr PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		4 ILE A  77
ILE A  57
LEU A 188
LEU A 133
 None
 0.89A 3adxA-4lkrA:
undetectable		 3adxA-4lkrA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq6 N-ACETYMURAMYL-L-ALA
NINE AMIDASE-RELATED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01520
(Amidase_3) 		4 ILE A 145
ILE A 173
LEU A 188
LEU A  57
 None
 0.96A 3adxA-4lq6A:
undetectable		 3adxA-4lq6A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lso TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Bartonella
quintana) 		PF04335
(VirB8) 		4 ILE A 101
ILE A 165
LEU A 219
LEU A 200
 None
 0.83A 3adxA-4lsoA:
undetectable		 3adxA-4lsoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE

(Thermococcus
onnurineus) 		PF02006
(PPS_PS) 		4 ILE A  47
ILE A 254
LEU A 182
PHE A  43
 None
None
ATP  A 301 (-3.8A)
None
 0.92A 3adxA-4mb2A:
undetectable		 3adxA-4mb2A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4msp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP14

(Homo sapiens) 		PF00254
(FKBP_C)
PF13499
(EF-hand_7) 		4 ILE A 110
LEU A  84
PHE A 108
LEU A  43
 None
 0.83A 3adxA-4mspA:
undetectable		 3adxA-4mspA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu2 ANTIFREEZE PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		4 ILE A 195
ILE A 180
LEU A  62
LEU A 212
 None
 0.94A 3adxA-4nu2A:
undetectable		 3adxA-4nu2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu7 RIBULOSE-PHOSPHATE
3-EPIMERASE

(Toxoplasma
gondii) 		PF00834
(Ribul_P_3_epim) 		4 ILE A  92
ILE A   8
LEU A  72
PHE A  94
 None
 0.85A 3adxA-4nu7A:
undetectable		 3adxA-4nu7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oca UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 269
LEU A 363
PHE A 299
LEU A 280
 None
 0.99A 3adxA-4ocaA:
undetectable		 3adxA-4ocaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omb PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		4 ILE A 225
ILE A 230
LEU A 178
PHE A 179
 None
 0.75A 3adxA-4ombA:
undetectable		 3adxA-4ombA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovd PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ILE A 432
LEU A 296
PHE A 428
LEU A 424
 None
 0.98A 3adxA-4ovdA:
undetectable		 3adxA-4ovdA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pii N-GLYCOSYLASE/DNA
LYASE

(Pyrococcus
furiosus) 		PF09171
(AGOG) 		4 ILE A 213
ILE A  13
LEU A 240
LEU A 229
 None
CL  A 305 (-4.5A)
None
None
 0.83A 3adxA-4piiA:
undetectable		 3adxA-4piiA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqj PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		4 ILE A 225
ILE A 230
LEU A 178
PHE A 179
 None
 0.73A 3adxA-4pqjA:
undetectable		 3adxA-4pqjA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r01 PUTATIVE NADH-FLAVIN
REDUCTASE

(Streptococcus
pneumoniae) 		PF13460
(NAD_binding_10) 		4 ILE A  62
ILE A  42
PHE A  94
LEU A  50
 None
 0.97A 3adxA-4r01A:
undetectable		 3adxA-4r01A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		4 ILE A 292
LEU A 268
PHE A 294
LEU A 420
 None
 0.78A 3adxA-4rzzA:
undetectable		 3adxA-4rzzA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 ILE A 301
ILE A 264
LEU A 472
PHE A 465
 None
 0.96A 3adxA-4wd9A:
undetectable		 3adxA-4wd9A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7p ALKALINE D-PEPTIDASE

(Bacillus cereus) 		PF00144
(Beta-lactamase) 		4 ILE A  38
ILE A 217
LEU A  31
PHE A  35
 None
 0.98A 3adxA-4y7pA:
undetectable		 3adxA-4y7pA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 ILE A1921
LEU A1929
PHE A1930
LEU A1814
 None
 0.91A 3adxA-4yknA:
undetectable		 3adxA-4yknA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 538
ILE A 573
LEU A 499
LEU A 607
 None
 0.81A 3adxA-4z61A:
undetectable		 3adxA-4z61A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ILE A 528
ILE A 563
LEU A 489
LEU A 597
 None
 0.88A 3adxA-4z64A:
undetectable		 3adxA-4z64A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b23 UNCHARACTERIZED
PROTEIN SORTASE B

(Clostridium
perfringens) 		PF04203
(Sortase) 		4 ILE A 226
ILE A 147
LEU A 204
LEU A 186
 None
 0.83A 3adxA-5b23A:
undetectable		 3adxA-5b23A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bow INTERLEUKIN-1 FAMILY
MEMBER 10

(Homo sapiens) 		PF00340
(IL1) 		4 ILE A  57
ILE A  11
PHE A 101
LEU A  27
 None
 0.90A 3adxA-5bowA:
undetectable		 3adxA-5bowA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ILE A 521
ILE A1058
LEU A 502
LEU A 485
 None
 0.82A 3adxA-5e02A:
undetectable		 3adxA-5e02A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Homo sapiens) 		PF00903
(Glyoxalase)
PF13669
(Glyoxalase_4) 		4 ILE A 267
ILE A 274
LEU A 346
LEU A 367
 ILE  A 267 ( 0.6A)
ILE  A 274 ( 0.7A)
LEU  A 346 ( 0.6A)
LEU  A 367 ( 0.6A)
 0.71A 3adxA-5ec3A:
undetectable		 3adxA-5ec3A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ILE B 555
LEU B 725
PHE B 649
LEU B 644
 None
 0.95A 3adxA-5hb4B:
undetectable		 3adxA-5hb4B:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ILE B1100
LEU B1070
PHE B1067
LEU B1052
 None
 0.98A 3adxA-5hb4B:
undetectable		 3adxA-5hb4B:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 ILE A 637
ILE A 292
LEU A 633
LEU A 400
 None
 0.85A 3adxA-5i4eA:
undetectable		 3adxA-5i4eA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ILE B 489
ILE B 682
PHE B 498
LEU B 541
 None
 0.88A 3adxA-5kyuB:
undetectable		 3adxA-5kyuB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tja MUCOLIPIN-1

(Homo sapiens) 		no annotation 4 ILE A 260
LEU A 106
PHE A 105
LEU A 137
 None
 0.86A 3adxA-5tjaA:
undetectable		 3adxA-5tjaA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Enterococcus
faecalis) 		no annotation 4 ILE A 180
ILE A 235
LEU A 312
LEU A  37
 None
 0.76A 3adxA-5v2mA:
undetectable		 3adxA-5v2mA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3w ARYLDIALKYLPHOSPHATA
SE

(Sulfolobus
solfataricus) 		no annotation 4 ILE A  21
ILE A 288
LEU A 196
PHE A 218
 None
 0.99A 3adxA-5w3wA:
undetectable		 3adxA-5w3wA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 255
ILE A  81
LEU A 289
LEU A 309
 None
 0.91A 3adxA-5xd7A:
undetectable		 3adxA-5xd7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 ILE A 921
LEU A 929
PHE A 930
LEU A 814
 None
 0.91A 3adxA-5xgjA:
undetectable		 3adxA-5xgjA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yq7 PRECURSOR FOR M
SUBUNITS OF
PHOTOSYNTHETIC
REACTION CENTER

(Roseiflexus
castenholzii) 		no annotation 4 ILE M 505
LEU M 489
PHE M 486
LEU M 479
 BPH  M 703 (-4.1A)
None
None
BCL  M 702 (-4.6A)
 0.87A 3adxA-5yq7M:
undetectable		 3adxA-5yq7M:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6beg SCAFFOLD PROTEIN D13

(Vaccinia virus) 		no annotation 4 ILE A 178
ILE A  53
LEU A 171
LEU A  71
 None
 0.95A 3adxA-6begA:
undetectable		 3adxA-6begA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 4 ILE M 467
ILE M 994
LEU M 448
LEU M 431
 None
 0.92A 3adxA-6d6qM:
undetectable		 3adxA-6d6qM:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 4 ILE A 453
ILE A 431
LEU A 443
LEU A 107
 None
 0.94A 3adxA-6gctA:
undetectable		 3adxA-6gctA:
13.33