SIMILAR PATTERNS OF AMINO ACIDS FOR 3ADS_B_IMNB3_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (BETA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 ILE B 122
GLY B 125
SER B 130
ALA B 133
ILE B 503
 None
 0.70A 3adsB-1a6dB:
0.2		 3adsB-1a6dB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB) 		5 GLY B 191
ILE B 214
LEU B 217
LEU B 224
MET B 249
 FE  B 501 ( 4.8A)
None
None
None
None
 1.31A 3adsB-1bouB:
undetectable		 3adsB-1bouB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 GLY A  68
ALA A 387
LEU A 350
VAL A  16
ILE A  71
 None
 1.37A 3adsB-1dedA:
0.0		 3adsB-1dedA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		5 ILE A 310
SER A 267
ILE A 303
VAL A 320
ILE A 323
 SAH  A 529 (-4.3A)
None
None
None
None
 1.15A 3adsB-1f3lA:
undetectable		 3adsB-1f3lA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 346
CYH A 345
ALA A 252
LEU A 381
LEU A 384
 None
 1.27A 3adsB-1gzkA:
undetectable		 3adsB-1gzkA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1is1 RIBOSOME RECYCLING
FACTOR

(Vibrio
parahaemolyticus) 		PF01765
(RRF) 		5 GLY A  88
SER A  85
ALA A  81
ILE A  40
LEU A  37
 None
 1.27A 3adsB-1is1A:
0.0		 3adsB-1is1A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k20 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Streptococcus
gordonii) 		PF01368
(DHH)
PF02833
(DHHA2) 		5 ALA A 243
ILE A 240
LEU A 254
VAL A 221
ILE A 204
 None
None
None
GOL  A 710 (-4.2A)
GOL  A 710 ( 4.7A)
 0.98A 3adsB-1k20A:
0.0		 3adsB-1k20A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmi PHOSPHOMANNOSE
ISOMERASE

(Candida
albicans) 		PF01238
(PMI_typeI) 		5 ILE A  85
GLY A 380
LEU A  69
LEU A  72
VAL A  73
 None
 1.15A 3adsB-1pmiA:
0.0		 3adsB-1pmiA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcd ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Leishmania
donovani) 		PF00156
(Pribosyltran) 		5 ILE A 145
GLY A  83
LEU A  55
ILE A 175
MET A  89
 None
 1.30A 3adsB-1qcdA:
0.0		 3adsB-1qcdA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryn PROTEIN CRS2

(Zea mays) 		PF01195
(Pept_tRNA_hydro) 		5 ILE A  38
LEU A  90
LEU A 176
VAL A 173
ILE A  54
 ILE  A  38 ( 0.6A)
LEU  A  90 ( 0.6A)
LEU  A 176 ( 0.6A)
VAL  A 173 ( 0.6A)
ILE  A  54 ( 0.7A)
 1.30A 3adsB-1rynA:
undetectable		 3adsB-1rynA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 ILE A 416
SER A 606
ALA A 602
LEU A 431
ILE A 581
 None
 1.24A 3adsB-1t1uA:
undetectable		 3adsB-1t1uA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmx HYDROXYQUINOL
1,2-DIOXYGENASE

(Pimelobacter
simplex) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 GLY A 186
LEU A 290
LEU A 234
VAL A 226
ILE A 153
 None
 1.25A 3adsB-1tmxA:
undetectable		 3adsB-1tmxA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE

(Nostoc sp. PCC
7120) 		PF00266
(Aminotran_5) 		5 ILE A 322
ILE A 373
LEU A 372
LEU A  26
VAL A 343
 None
 0.92A 3adsB-1vjoA:
undetectable		 3adsB-1vjoA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4m FAR UPSTREAM ELEMENT
BINDING PROTEIN 1

(Mus musculus) 		PF00013
(KH_1) 		5 ILE A  19
LEU A  28
VAL A  29
ILE A  84
MET A  50
 None
 1.22A 3adsB-1x4mA:
undetectable		 3adsB-1x4mA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xgw EPSIN 4

(Homo sapiens) 		PF01417
(ENTH) 		5 ALA A 151
ILE A 102
LEU A  98
LEU A  95
MET A  73
 None
 1.29A 3adsB-1xgwA:
undetectable		 3adsB-1xgwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983

(Mycobacterium
tuberculosis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 ALA A  90
ILE A  51
LEU A  22
VAL A  20
ILE A  37
 None
 0.80A 3adsB-1y8tA:
undetectable		 3adsB-1y8tA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zub REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 1

(Rattus
norvegicus) 		PF00595
(PDZ) 		5 ILE A 702
GLY A 675
SER A 693
LEU A 630
ILE A 615
 None
 1.15A 3adsB-1zubA:
undetectable		 3adsB-1zubA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chg REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA) 		5 GLY A 206
ILE A 173
LEU A 170
LEU A 186
ILE A 219
 None
 1.18A 3adsB-2chgA:
undetectable		 3adsB-2chgA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chq REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 GLY A 206
ILE A 173
LEU A 170
LEU A 186
ILE A 219
 None
 1.03A 3adsB-2chqA:
undetectable		 3adsB-2chqA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		5 ALA A 334
ILE A 417
LEU A 439
VAL A 448
ILE A 370
 None
 1.29A 3adsB-2cn3A:
undetectable		 3adsB-2cn3A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fko 173AA LONG
HYPOTHETICAL
FERRIPYOCHELIN
BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00132
(Hexapep) 		5 GLY A  88
ALA A  84
ILE A  97
VAL A  52
ILE A  50
 None
 1.13A 3adsB-2fkoA:
undetectable		 3adsB-2fkoA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE

(Homo sapiens) 		PF00755
(Carn_acyltransf) 		5 ILE A 406
SER A 596
ALA A 592
LEU A 421
ILE A 571
 None
 1.28A 3adsB-2fy2A:
undetectable		 3adsB-2fy2A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt4 RESPONSE REGULATOR
HOMOLOG

(Myxococcus
xanthus) 		PF00072
(Response_reg) 		5 ILE A   5
ILE A  65
LEU A  69
LEU A  75
VAL A  78
 None
 1.01A 3adsB-2nt4A:
undetectable		 3adsB-2nt4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2on5 NA GLUTATHIONE
S-TRANSFERASE 2

(Necator
americanus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 GLY A  79
SER A  72
ALA A  68
ILE A  21
LEU A 158
 None
None
EDO  A 425 ( 3.8A)
None
None
 1.21A 3adsB-2on5A:
undetectable		 3adsB-2on5A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT

(Bacillus sp. D6) 		PF09491
(RE_AlwI) 		5 ILE A 113
ILE A  70
LEU A  94
VAL A  90
ILE A 121
 None
 0.97A 3adsB-2p14A:
undetectable		 3adsB-2p14A:
21.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ILE A 272
SER A 280
ILE A 317
LEU A 321
MET A 355
 735  A 469 ( 4.2A)
735  A 469 (-2.8A)
735  A 469 ( 4.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
 0.51A 3adsB-2p54A:
33.9		 3adsB-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 760
ILE A 749
LEU A 748
VAL A 735
ILE A 733
 None
 1.20A 3adsB-2pffA:
undetectable		 3adsB-2pffA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 GLY A 186
ALA A 217
ILE A 357
LEU A 313
VAL A 230
 None
 0.93A 3adsB-2q6tA:
undetectable		 3adsB-2q6tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 310
ILE A 305
LEU A 331
LEU A 355
ILE A 357
 None
 1.34A 3adsB-2wd9A:
undetectable		 3adsB-2wd9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		5 GLY A 435
ILE A  69
LEU A  72
VAL A 217
ILE A  15
 None
 1.38A 3adsB-2yg6A:
undetectable		 3adsB-2yg6A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 SER A 596
ALA A 595
ILE A 606
LEU A 610
LEU A 613
 None
 1.20A 3adsB-2zxhA:
undetectable		 3adsB-2zxhA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1

(Homo sapiens) 		PF02144
(Rad1) 		5 ILE C 134
ALA C  63
ILE C  65
LEU C  27
MET C 110
 None
 1.28A 3adsB-3a1jC:
undetectable		 3adsB-3a1jC:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 GLY A 284
ARG A 288
SER A 289
ALA A 292
ILE A 326
LEU A 330
LEU A 333
VAL A 339
 MC5  A   1 ( 4.5A)
None
MC5  A   1 (-2.6A)
None
MC5  A   1 ( 4.9A)
MC5  A   1 (-4.4A)
None
MC5  A   1 (-4.6A)
 0.59A 3adsB-3b0qA:
36.8		 3adsB-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 GLY A 284
CYH A 285
ARG A 288
LEU A 330
LEU A 333
VAL A 339
MET A 364
 MC5  A   1 ( 4.5A)
MC5  A   1 (-3.6A)
None
MC5  A   1 (-4.4A)
None
MC5  A   1 (-4.6A)
MC5  A   1 (-3.7A)
 0.77A 3adsB-3b0qA:
36.8		 3adsB-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 ILE A 281
GLY A 284
ARG A 288
ALA A 292
ILE A 326
LEU A 330
LEU A 333
VAL A 339
ILE A 341
MET A 364
 MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.5A)
None
None
MC5  A   1 ( 4.9A)
MC5  A   1 (-4.4A)
None
MC5  A   1 (-4.6A)
MC5  A   1 (-4.5A)
MC5  A   1 (-3.7A)
 0.44A 3adsB-3b0qA:
36.8		 3adsB-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		5 ILE A 367
ILE A 343
LEU A 379
LEU A 357
VAL A 359
 None
 1.30A 3adsB-3bolA:
undetectable		 3adsB-3bolA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwt PROTEIN PUF4

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		5 ILE A 880
SER A 793
ALA A 789
ILE A 802
LEU A 806
 None
 1.31A 3adsB-3bwtA:
undetectable		 3adsB-3bwtA:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		10 ILE D 281
CYH D 285
SER D 289
ALA D 292
ILE D 326
LEU D 330
LEU D 333
VAL D 339
ILE D 341
MET D 364
 PLB  D 701 (-4.6A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.5A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-4.4A)
None
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.8A)
 0.54A 3adsB-3dzuD:
34.0		 3adsB-3dzuD:
94.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		10 ILE D 281
GLY D 284
CYH D 285
SER D 289
ALA D 292
ILE D 326
LEU D 330
VAL D 339
ILE D 341
MET D 364
 PLB  D 701 (-4.6A)
PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.5A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.8A)
 0.45A 3adsB-3dzuD:
34.0		 3adsB-3dzuD:
94.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ALA A 307
ILE A 175
LEU A 174
VAL A 224
ILE A 222
 None
 1.21A 3adsB-3ec7A:
undetectable		 3adsB-3ec7A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		5 GLY A 168
SER A 266
ILE A 242
LEU A 241
LEU A 237
 None
None
MYR  A 315 ( 4.8A)
None
None
 1.37A 3adsB-3ee4A:
2.1		 3adsB-3ee4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esi UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07977
(FabA) 		5 GLY A  45
SER A 113
LEU A  84
LEU A  24
VAL A  26
 None
 1.28A 3adsB-3esiA:
undetectable		 3adsB-3esiA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1r FIBROBLAST GROWTH
FACTOR 20

(Homo sapiens) 		PF00167
(FGF) 		5 ILE A 110
ARG A 140
SER A 153
ILE A 155
VAL A 103
 None
SO4  A 301 (-3.4A)
None
None
None
 1.18A 3adsB-3f1rA:
undetectable		 3adsB-3f1rA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy3 HEMOLYSIN

(Proteus
mirabilis) 		PF05860
(Haemagg_act) 		5 GLY A 205
ALA A 209
ILE A 212
LEU A 196
LEU A 157
 None
 1.01A 3adsB-3fy3A:
undetectable		 3adsB-3fy3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7t GROUP 3 ALLERGEN
SMIPP-S YVT004A06

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		5 GLY A 187
SER A  29
ILE A 105
LEU A 121
VAL A 120
 None
 1.22A 3adsB-3h7tA:
undetectable		 3adsB-3h7tA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd4 PUTATIVE PROTEASE

(Parabacteroides
distasonis) 		PF12969
(DUF3857)
PF12970
(DUF3858) 		5 GLY A 426
ILE A 444
LEU A 495
LEU A 511
VAL A 508
 None
 1.26A 3adsB-3kd4A:
undetectable		 3adsB-3kd4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN

(Chloroflexus
aurantiacus) 		PF01872
(RibD_C) 		5 ILE A   8
GLY A 151
LEU A 163
VAL A 164
ILE A 148
 NDP  A 301 (-3.6A)
NDP  A 301 (-3.3A)
EDO  A 216 ( 4.6A)
None
None
 1.24A 3adsB-3kgyA:
undetectable		 3adsB-3kgyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqg LIPOPOLYSACCHARIDES
BIOSYNTHESIS
ACETYLTRANSFERASE

(Bordetella
petrii) 		PF00132
(Hexapep) 		5 GLY A  77
ALA A 107
ILE A 121
VAL A  64
ILE A  58
 None
 1.10A 3adsB-3mqgA:
undetectable		 3adsB-3mqgA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qg5 RAD50

(Thermotoga
maritima) 		PF13476
(AAA_23)
PF13558
(SbcCD_C) 		5 GLY A 770
ALA A 764
ILE A 755
LEU A 779
ILE A 777
 None
 1.02A 3adsB-3qg5A:
undetectable		 3adsB-3qg5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		5 ILE A 966
GLY A 959
LEU A 911
VAL A 900
ILE A 896
 None
 1.29A 3adsB-3tsyA:
undetectable		 3adsB-3tsyA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		5 SER B 190
ALA B  11
LEU B 135
LEU B  56
VAL B 146
 None
 0.99A 3adsB-3vsjB:
undetectable		 3adsB-3vsjB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		5 GLY A 192
ILE A  58
LEU A  44
VAL A  47
ILE A 259
 None
 1.07A 3adsB-3zrpA:
undetectable		 3adsB-3zrpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		5 ALA A 210
ILE A 156
LEU A 158
LEU A 173
VAL A 172
 None
 1.24A 3adsB-3zukA:
undetectable		 3adsB-3zukA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9a PROBABLE EPOXIDE
HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 ALA A 280
ILE A 270
LEU A 242
VAL A 128
ILE A 104
 SO4  A1304 (-3.7A)
None
None
None
None
 1.19A 3adsB-4b9aA:
undetectable		 3adsB-4b9aA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 5 GLY A 687
LEU A 485
LEU A 486
VAL A 487
MET A 450
 None
 1.25A 3adsB-4btpA:
undetectable		 3adsB-4btpA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 ILE H 594
ILE H 608
LEU H 637
LEU H 615
ILE H 555
 None
 1.33A 3adsB-4c8qH:
undetectable		 3adsB-4c8qH:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4co6 NUCLEOPROTEIN

(Nipah
henipavirus) 		PF00973
(Paramyxo_ncap) 		5 GLY A 305
ILE A 318
LEU A 314
LEU A 313
VAL A 232
 None
 1.02A 3adsB-4co6A:
undetectable		 3adsB-4co6A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efi 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE

(Paraburkholderia
xenovorans) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A  21
ALA A  76
ILE A 356
LEU A 312
ILE A 314
 None
 1.29A 3adsB-4efiA:
undetectable		 3adsB-4efiA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etw ACYL CARRIER PROTEIN

(Shigella
flexneri) 		no annotation 5 GLY D 573
ILE D 553
LEU D 545
VAL D 506
ILE D 568
 None
 1.13A 3adsB-4etwD:
undetectable		 3adsB-4etwD:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjf GGDEF FAMILY PROTEIN

(Caulobacter
vibrioides) 		PF00563
(EAL) 		5 ALA A 439
LEU A 443
LEU A 415
VAL A 417
ILE A 390
 None
 1.12A 3adsB-4hjfA:
undetectable		 3adsB-4hjfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT

(Enterococcus
faecalis) 		PF02518
(HATPase_c) 		5 ILE A 189
LEU A 190
LEU A 208
VAL A  64
ILE A 206
 None
 1.34A 3adsB-4hz5A:
undetectable		 3adsB-4hz5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1i MALATE DEHYDROGENASE

(Leishmania
major) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  87
ALA A  76
LEU A  49
LEU A  46
ILE A  42
 NAD  A 400 (-3.2A)
None
None
EDO  A 402 (-4.2A)
NAD  A 400 (-3.8A)
 0.93A 3adsB-4i1iA:
undetectable		 3adsB-4i1iA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae) 		PF02073
(Peptidase_M29) 		5 ILE A 292
SER A 269
LEU A 273
VAL A 382
MET A 304
 None
 1.24A 3adsB-4icqA:
undetectable		 3adsB-4icqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iru LEPB

(Legionella
pneumophila) 		no annotation 5 ILE A 478
GLY A 476
ALA A 513
LEU A 381
VAL A 378
 None
None
None
K  A 912 ( 4.9A)
None
 1.30A 3adsB-4iruA:
undetectable		 3adsB-4iruA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jer HEMOPHORE HASA

(Yersinia pestis) 		PF06438
(HasA) 		5 ALA A  69
ILE A  87
LEU A 119
ILE A 114
MET A 158
 None
 0.97A 3adsB-4jerA:
undetectable		 3adsB-4jerA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
drancourtii) 		no annotation 5 GLY A 353
ALA A 508
ILE A 480
LEU A 484
VAL A 363
 None
 1.10A 3adsB-4jvsA:
undetectable		 3adsB-4jvsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A 111
ILE A 159
LEU A 161
VAL A 198
ILE A 151
 None
 1.32A 3adsB-4lutA:
undetectable		 3adsB-4lutA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 5 ILE B 225
ILE B 166
LEU B  53
VAL B   5
ILE B  26
 None
 1.01A 3adsB-4mkiB:
undetectable		 3adsB-4mkiB:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		5 ALA A 974
ILE A 953
LEU A 952
VAL A 409
ILE A 436
 None
 1.34A 3adsB-4mt1A:
undetectable		 3adsB-4mt1A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 GLY A  68
CYH A  67
ILE A   3
LEU A  24
ILE A  13
 None
 1.23A 3adsB-4njvA:
undetectable		 3adsB-4njvA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1k CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		5 ILE A 191
GLY A 193
LEU A  83
VAL A  84
ILE A  54
 None
 1.13A 3adsB-4o1kA:
undetectable		 3adsB-4o1kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		5 ILE A  30
GLY A 136
SER A  87
LEU A 143
LEU A 142
 None
 1.30A 3adsB-4oetA:
undetectable		 3adsB-4oetA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1z PIWI-LIKE PROTEIN 1

(Mus musculus) 		PF02171
(Piwi) 		5 ALA A 530
ILE A 513
LEU A 512
LEU A 560
VAL A 587
 None
 1.22A 3adsB-4p1zA:
undetectable		 3adsB-4p1zA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px9 ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD) 		5 CYH A 223
SER A 382
ALA A 349
ILE A 389
LEU A 397
 None
 0.90A 3adsB-4px9A:
undetectable		 3adsB-4px9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 GLY A 102
LEU A  71
LEU A  74
VAL A  98
ILE A  47
 None
 1.02A 3adsB-4r7yA:
undetectable		 3adsB-4r7yA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		5 SER A 344
ALA A 187
LEU A  62
VAL A 311
ILE A 308
 None
 1.33A 3adsB-4r9iA:
undetectable		 3adsB-4r9iA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl6 SACCHAROPINE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 GLY A 164
SER A 170
ILE A 184
LEU A 187
ILE A 327
 None
 1.22A 3adsB-4rl6A:
undetectable		 3adsB-4rl6A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 GLY A 119
CYH A 120
ALA A 100
LEU A 162
VAL A 164
 None
 0.93A 3adsB-4roeA:
undetectable		 3adsB-4roeA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 GLY C  52
SER C  49
ILE C  56
LEU C  37
MET A 113
 None
 1.11A 3adsB-4yfaC:
undetectable		 3adsB-4yfaC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 ILE A  90
GLY A  49
CYH A  48
ILE A  70
LEU A  44
 None
 1.33A 3adsB-5a0tA:
undetectable		 3adsB-5a0tA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 GLY A 254
SER A 251
ILE A 258
LEU A 239
MET A 113
 None
 1.16A 3adsB-5c9iA:
undetectable		 3adsB-5c9iA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 CYH A 223
SER A 382
ALA A 349
ILE A 389
LEU A 397
 None
 0.94A 3adsB-5e7jA:
undetectable		 3adsB-5e7jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 5 ILE C 273
ALA C 259
ILE C 266
LEU C 252
VAL C 251
 None
 1.01A 3adsB-5elpC:
undetectable		 3adsB-5elpC:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 212
CYH A 167
ALA A 241
LEU A 267
MET A 152
 None
 1.31A 3adsB-5elxA:
undetectable		 3adsB-5elxA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ew5 COLICIN-E9

(Escherichia
coli) 		PF03515
(Cloacin) 		5 ALA A 271
ILE A 225
LEU A 231
VAL A 105
ILE A 107
 None
 1.32A 3adsB-5ew5A:
undetectable		 3adsB-5ew5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 GLY A  55
LEU A 133
LEU A 196
VAL A 195
ILE A 191
 None
 1.02A 3adsB-5f5oA:
undetectable		 3adsB-5f5oA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		5 ILE A 501
ARG A 660
SER A 515
ALA A 518
ILE A 663
 None
 1.07A 3adsB-5fbuA:
undetectable		 3adsB-5fbuA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ILE A 338
LEU A 142
LEU A 141
ILE A 186
MET A 279
 None
EDO  A1881 ( 4.0A)
None
None
None
 1.26A 3adsB-5fjiA:
undetectable		 3adsB-5fjiA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME COMPONENT
C8, PUTATIVE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ILE G 151
CYH G 153
SER G 137
ALA G 136
ILE G  31
 None
 1.15A 3adsB-5fmgG:
undetectable		 3adsB-5fmgG:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmk PRE-MRNA-SPLICING
FACTOR CWC22

(Saccharomyces
cerevisiae) 		PF02847
(MA3) 		5 ILE Z 200
ILE Z 135
LEU Z 139
LEU Z 142
ILE Z 152
 None
 1.21A 3adsB-5gmkZ:
undetectable		 3adsB-5gmkZ:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpe SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Candida
albicans) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		5 GLY A 256
ILE A 240
LEU A 237
LEU A 271
ILE A 269
 None
 1.23A 3adsB-5jpeA:
undetectable		 3adsB-5jpeA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l94 CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		5 ILE A 232
GLY A 234
ALA A 242
ILE A 147
VAL A  99
 None
None
HEM  A 501 (-3.5A)
None
None
 1.21A 3adsB-5l94A:
undetectable		 3adsB-5l94A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6p TYROCIDINE SYNTHASE
2

(Brevibacillus
parabrevis) 		no annotation 5 GLY A3528
SER A3515
ALA A3516
LEU A3393
ILE A3474
 None
 1.31A 3adsB-5m6pA:
undetectable		 3adsB-5m6pA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN7

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF10602
(RPN7) 		5 ARG R 206
ILE R 241
LEU R 172
VAL R 194
ILE R 198
 None
 1.18A 3adsB-5mpdR:
undetectable		 3adsB-5mpdR:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1

(Homo sapiens) 		no annotation 5 SER A 283
ALA A  40
ILE A  96
LEU A  92
LEU A  89
 None
 0.96A 3adsB-5o9hA:
undetectable		 3adsB-5o9hA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj7 NAD-DEPENDENT
PROTEIN DEACYLASE

(Xenopus
tropicalis) 		no annotation 5 ILE A  64
GLY A 259
ALA A 291
ILE A 281
VAL A 140
 None
AR6  A 401 (-3.6A)
None
None
None
 1.17A 3adsB-5oj7A:
undetectable		 3adsB-5oj7A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu0 LMO2125 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		5 ILE A 374
GLY A 211
ALA A 200
LEU A 219
VAL A 380
 None
 1.38A 3adsB-5tu0A:
undetectable		 3adsB-5tu0A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		5 GLY F 144
ILE F 399
LEU F 395
VAL F 389
ILE F 382
 None
 1.03A 3adsB-5u7xF:
undetectable		 3adsB-5u7xF:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wuf PUTATIVE MEMBRANE
PROTEIN

(Colwellia
psychrerythraea) 		PF03458
(UPF0126) 		5 GLY A  33
SER A  39
ALA A  17
ILE A  69
LEU A  70
 CD  A 301 ( 4.2A)
None
None
None
None
 1.16A 3adsB-5wufA:
undetectable		 3adsB-5wufA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1q SOLUBLE CYTOCHROME
B562, C5A
ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 SER B 369
ALA B 126
ILE B 182
LEU B 178
LEU B 175
 None
 0.96A 3adsB-6c1qB:
undetectable		 3adsB-6c1qB:
12.50