SIMILAR PATTERNS OF AMINO ACIDS FOR 3ADS_A_IMNA1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT

(Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 GLU A 309
ARG A 529
ILE A 311
GLY A 314
LEU A 471
 None
 1.25A 3adsA-1e6vA:
0.6		 3adsA-1e6vA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens) 		PF01852
(START) 		5 GLU A 237
ARG A 240
ILE A 239
GLY A 242
ARG A 351
 None
 1.28A 3adsA-1em2A:
0.0		 3adsA-1em2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em2 MLN64 PROTEIN

(Homo sapiens) 		PF01852
(START) 		5 GLU A 354
ILE A 389
GLY A 387
LEU A 434
ILE A 301
 None
 1.05A 3adsA-1em2A:
0.0		 3adsA-1em2A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		5 GLU A 410
ILE A 215
CYH A 217
LEU A 274
ILE A 407
 None
 0.94A 3adsA-1floA:
0.9		 3adsA-1floA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzs SOPE

(Salmonella
enterica) 		PF07487
(SopE_GEF) 		5 GLU B 208
ARG B  97
LEU B 153
ILE B 114
MET B 218
 None
 1.32A 3adsA-1gzsB:
0.2		 3adsA-1gzsB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jym PEPTIDE DEFORMYLASE

(Plasmodium
falciparum) 		PF01327
(Pep_deformylase) 		5 ILE A 160
GLY A 154
CYH A 155
LEU A  75
ILE A 207
 None
None
CO  A 300 (-2.2A)
None
None
 1.34A 3adsA-1jymA:
undetectable		 3adsA-1jymA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		5 GLU A 407
GLY A 194
LEU A 175
ILE A 168
MET A 207
 None
 1.39A 3adsA-1ocmA:
undetectable		 3adsA-1ocmA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og0 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Saccharomyces
cerevisiae) 		PF00793
(DAHP_synth_1) 		5 GLU A 158
ILE A 247
GLY A 199
ILE A  72
MET A 314
 None
 1.46A 3adsA-1og0A:
0.0		 3adsA-1og0A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE

(Plasmodium
falciparum) 		PF00709
(Adenylsucc_synt) 		5 GLU A 128
GLY A 146
CYH A 148
LEU A 176
ILE A 123
 None
IMO  A1601 ( 4.9A)
None
None
None
 1.11A 3adsA-1p9bA:
undetectable		 3adsA-1p9bA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ARG A 348
ILE A 191
GLY A 192
LEU A 246
ILE A 198
 None
 1.44A 3adsA-1q1nA:
0.0		 3adsA-1q1nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh0 HYPOTHETICAL UPF0247
PROTEIN
SAV0024/SA0023

(Staphylococcus
aureus) 		PF02590
(SPOUT_MTase) 		5 GLU A  37
ILE A 107
GLY A 109
LEU A 118
ILE A  63
 None
 1.09A 3adsA-1vh0A:
undetectable		 3adsA-1vh0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ILE A 488
GLY A 503
LEU A 400
MET A 420
MET A 583
 None
 1.27A 3adsA-1xjeA:
undetectable		 3adsA-1xjeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl7 ENTEROCINE A
IMMUNITY PROTEIN

(Enterococcus
faecium) 		PF08951
(EntA_Immun) 		5 GLU A  75
ARG A  78
ILE A  77
LEU A  38
ILE A   8
 None
 1.46A 3adsA-2bl7A:
undetectable		 3adsA-2bl7A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn1 CYTOSOLIC
5'-NUCLEOTIDASE III

(Homo sapiens) 		PF05822
(UMPH-1) 		5 GLU A 162
ARG A 165
ILE A 164
GLY A 168
LEU A 275
 None
 1.33A 3adsA-2cn1A:
undetectable		 3adsA-2cn1A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ARG A  20
ILE A 297
GLY A  86
LEU A 115
ILE A 108
 None
 1.34A 3adsA-2dzdA:
undetectable		 3adsA-2dzdA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		5 GLU A 338
ILE A 328
GLY A 299
LEU A 295
ILE A 127
 None
 1.24A 3adsA-2e3jA:
undetectable		 3adsA-2e3jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		5 ARG A 953
ILE A 952
GLY A 956
ILE A 759
MET A 976
 None
 1.29A 3adsA-2eyqA:
undetectable		 3adsA-2eyqA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faq PROBABLE
ATP-DEPENDENT DNA
LIGASE

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 613
GLY A 615
ARG A 634
LEU A 619
ILE A 633
 None
 1.11A 3adsA-2faqA:
undetectable		 3adsA-2faqA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6y GREEN FLUORESCENT
PROTEIN 2

(Pontellina
plumata) 		PF01353
(GFP) 		5 ILE A   6
GLY A  23
CYH A   8
ARG A   9
ILE A 111
 None
 1.22A 3adsA-2g6yA:
undetectable		 3adsA-2g6yA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 GLU A 105
ILE A 236
GLY A 102
LEU A 323
ILE A  94
 None
 1.26A 3adsA-2h8oA:
undetectable		 3adsA-2h8oA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2s PUTATIVE
OXIDOREDUCTASE

(Pectobacterium
atrosepticum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLU A  58
ARG A  84
ILE A   9
LEU A  23
ILE A  66
 None
 1.46A 3adsA-2p2sA:
undetectable		 3adsA-2p2sA:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLU A 251
ARG A 271
ILE A 272
LEU A 321
MET A 355
 None
None
735  A 469 ( 4.2A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
 0.93A 3adsA-2p54A:
37.1		 3adsA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py6 METHYLTRANSFERASE
FKBM

(Methylobacillus
flagellatus) 		PF05050
(Methyltransf_21) 		5 ILE A 327
GLY A 352
LEU A 378
ILE A 357
MET A 340
 None
 1.21A 3adsA-2py6A:
undetectable		 3adsA-2py6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 GLU A  99
ILE A  40
GLY A  12
ILE A  84
MET A 103
 None
None
SO4  A 318 ( 3.3A)
None
None
 1.06A 3adsA-2qytA:
undetectable		 3adsA-2qytA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvg KINESIN-2

(Giardia
intestinalis) 		PF00225
(Kinesin) 		5 GLU A  19
ARG A  13
ILE A 312
ARG A  29
ILE A  27
 None
 1.28A 3adsA-2vvgA:
undetectable		 3adsA-2vvgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xok ATP SYNTHASE SUBUNIT
GAMMA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00231
(ATP-synt) 		6 GLU G 229
ILE G 133
GLY G 111
LEU G 150
ILE G  77
MET G 222
 None
 1.38A 3adsA-2xokG:
undetectable		 3adsA-2xokG:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 GLU A 622
ARG A 650
ILE A 648
LEU A 736
ILE A 639
 None
 1.33A 3adsA-2xvgA:
undetectable		 3adsA-2xvgA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y30 PUTATIVE REPRESSOR
SIMREG2

(Streptomyces
antibioticus) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 GLU A 152
ILE A 157
GLY A 158
LEU A 230
ILE A 237
 None
 1.42A 3adsA-2y30A:
undetectable		 3adsA-2y30A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxh TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Aquifex
aeolicus) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		5 GLU A 386
ILE A  52
GLY A  58
ILE A  64
MET A  71
 FAD  A 618 ( 4.6A)
None
None
None
None
 1.37A 3adsA-2zxhA:
undetectable		 3adsA-2zxhA:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 GLU A 259
ARG A 280
ILE A 281
GLY A 284
LEU A 330
ILE A 341
MET A 348
MET A 364
 None
None
MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.5A)
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
MC5  A   1 (-3.7A)
 0.72A 3adsA-3b0qA:
42.0		 3adsA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 GLU A 259
ILE A 281
GLY A 284
ARG A 288
LEU A 330
ILE A 341
MET A 348
MET A 364
 None
MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.5A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
MC5  A   1 (-3.7A)
 0.52A 3adsA-3b0qA:
42.0		 3adsA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 GLU A 259
ILE A 281
GLY A 284
CYH A 285
ARG A 288
LEU A 330
ILE A 341
MET A 364
 None
MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.5A)
MC5  A   1 (-3.6A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 (-3.7A)
 0.65A 3adsA-3b0qA:
42.0		 3adsA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dip ENOLASE

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A 280
ARG A 277
GLY A 274
CYH A 297
LEU A 334
 None
 1.41A 3adsA-3dipA:
undetectable		 3adsA-3dipA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 ARG D 280
ILE D 281
GLY D 284
CYH D 285
LEU D 330
ILE D 341
MET D 348
MET D 364
 None
PLB  D 701 (-4.6A)
PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
 0.66A 3adsA-3dzuD:
37.2		 3adsA-3dzuD:
94.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e54 RRNA INTRON-ENCODED
ENDONUCLEASE

(Vulcanisaeta
distributa) 		PF00961
(LAGLIDADG_1) 		5 ILE A 156
GLY A  35
ARG A  37
LEU A 115
ILE A  26
 None
 1.07A 3adsA-3e54A:
undetectable		 3adsA-3e54A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		5 GLY A  97
ARG A  95
LEU A 145
ILE A 109
MET A 162
 None
 1.35A 3adsA-3ed4A:
undetectable		 3adsA-3ed4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		5 GLU A 348
ARG A 508
GLY A 387
CYH A 386
LEU A 492
 ACT  A 709 ( 4.7A)
ACT  A 709 ( 3.8A)
None
None
None
 1.06A 3adsA-3eo7A:
undetectable		 3adsA-3eo7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)

(Clostridium
acetobutylicum) 		PF13377
(Peripla_BP_3) 		5 GLU A 300
ILE A 297
GLY A 278
ILE A  80
MET A 196
 None
None
None
None
GOL  A 401 (-3.8A)
 1.24A 3adsA-3g85A:
undetectable		 3adsA-3g85A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfa PUTATIVE
NITROREDUCTASE

(Clostridioides
difficile) 		PF00881
(Nitroreductase) 		5 GLU A  90
GLY A  84
LEU A  75
ILE A  65
MET A  61
 GOL  A 201 (-4.9A)
None
None
None
None
 1.38A 3adsA-3gfaA:
undetectable		 3adsA-3gfaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		5 ARG 3 178
ILE 3 211
ARG 3 186
LEU 3  39
ILE 3 226
 None
SF4  3 785 ( 4.5A)
None
None
None
 1.46A 3adsA-3i9v3:
undetectable		 3adsA-3i9v3:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfv CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF01590
(GAF) 		5 GLU A 374
ILE A 503
GLY A 500
CYH A 499
LEU A 492
 None
 1.48A 3adsA-3lfvA:
undetectable		 3adsA-3lfvA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtk DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Caldicellulosiruptor
saccharolyticus) 		PF00990
(GGDEF) 		5 ARG A 287
ILE A 257
GLY A 259
LEU A 199
ILE A 274
 None
 1.48A 3adsA-3mtkA:
undetectable		 3adsA-3mtkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odp PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Clostridium
novyi) 		PF01380
(SIS) 		5 GLU A 340
ILE A 199
GLY A 200
ARG A  32
ILE A 206
 None
 1.20A 3adsA-3odpA:
undetectable		 3adsA-3odpA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oe7 ATP SYNTHASE SUBUNIT
GAMMA

(Saccharomyces
cerevisiae) 		PF00231
(ATP-synt) 		6 GLU G 229
ILE G 133
GLY G 111
LEU G 150
ILE G  77
MET G 222
 None
 1.32A 3adsA-3oe7G:
undetectable		 3adsA-3oe7G:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oql TENA HOMOLOG

(Pseudomonas
syringae group
genomosp. 3) 		PF14518
(Haem_oxygenas_2) 		5 GLU A  87
ILE A 208
CYH A 210
LEU A  24
MET A 151
 None
 1.29A 3adsA-3oqlA:
undetectable		 3adsA-3oqlA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 327
GLY A 472
LEU A 166
MET A 292
MET A 205
 HEM  A 900 (-4.1A)
HEM  A 900 ( 4.0A)
None
None
None
 1.42A 3adsA-3pm0A:
undetectable		 3adsA-3pm0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
suis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 GLU A 136
ILE A 212
GLY A 202
LEU A  79
ILE A  55
 None
 1.46A 3adsA-3pquA:
undetectable		 3adsA-3pquA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		5 GLU B 360
ILE B 352
ARG B 300
LEU B 303
ILE B 296
 None
 1.19A 3adsA-3s4wB:
undetectable		 3adsA-3s4wB:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A 387
ARG A  24
LEU A  79
ILE A  25
MET A 114
 None
 1.46A 3adsA-3t9pA:
undetectable		 3adsA-3t9pA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1

(Toxoplasma
gondii) 		PF01150
(GDA1_CD39) 		5 ARG A 250
ILE A 488
GLY A 274
LEU A 567
ILE A 581
 None
 1.47A 3adsA-4a5aA:
undetectable		 3adsA-4a5aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av2 PILP PROTEIN

(Neisseria
meningitidis) 		PF04351
(PilP) 		5 ARG M  96
ILE M 111
GLY M 127
ARG M 132
ILE M 133
 None
 1.47A 3adsA-4av2M:
undetectable		 3adsA-4av2M:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 GLU P 509
ILE P 355
GLY P 396
LEU P 366
ILE P 263
 None
 1.47A 3adsA-4crnP:
undetectable		 3adsA-4crnP:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1l ACETOACETYL-COA
THIOLASE 2

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLU A  47
ILE A 270
GLY A  42
ILE A 258
MET A 260
 None
 1.47A 3adsA-4e1lA:
undetectable		 3adsA-4e1lA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmk RIBOSE-5-PHOSPHATE
ISOMERASE A

(Lactobacillus
salivarius) 		PF06026
(Rib_5-P_isom_A) 		5 GLU A  16
ILE A 214
GLY A  11
ILE A  83
MET A 117
 None
 1.35A 3adsA-4gmkA:
undetectable		 3adsA-4gmkA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htl BETA-GLUCOSIDE
KINASE

(Listeria
monocytogenes) 		PF00480
(ROK) 		5 ILE A  32
GLY A   9
LEU A  86
ILE A  78
MET A  44
 None
 1.17A 3adsA-4htlA:
undetectable		 3adsA-4htlA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4
CENTRAL KINETOCHORE
SUBUNIT IML3

(Saccharomyces
cerevisiae) 		PF05238
(CENP-N)
no annotation 		5 GLU A 171
ARG B 396
ILE B 398
LEU B 402
ILE A 165
 None
 1.46A 3adsA-4je3A:
undetectable		 3adsA-4je3A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lqb UNCHARACTERIZED
PROTEIN

(Kribbella
flavida) 		no annotation 5 GLU A  39
GLY A  95
ARG A  97
LEU A  99
ILE A 110
 GOL  A 201 ( 4.1A)
None
None
None
None
 1.36A 3adsA-4lqbA:
undetectable		 3adsA-4lqbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 WISKOTT-ALDRICH
SYNDROME PROTEIN
FAMILY MEMBER 1

(Homo sapiens) 		PF02205
(WH2) 		5 GLU D 503
ARG D 506
ILE D 505
GLY D 508
ILE D  95
 None
 1.36A 3adsA-4n78D:
undetectable		 3adsA-4n78D:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 GLU A 413
GLY A 410
CYH A 409
LEU A 495
ILE A 406
 None
 1.47A 3adsA-4nhoA:
undetectable		 3adsA-4nhoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phs PUTATIVE
GLYCOSYLTRANSFERASE
(GALT1)

(Streptococcus
parasanguinis) 		PF08759
(GT-D) 		5 GLU A 248
ARG A 116
GLY A  30
LEU A  51
ILE A  42
 None
UDP  A 301 (-4.1A)
None
None
None
 1.31A 3adsA-4phsA:
undetectable		 3adsA-4phsA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		5 GLU A 293
ARG A 289
ILE A 238
GLY A 287
ILE A 207
 None
 1.32A 3adsA-4q3rA:
undetectable		 3adsA-4q3rA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 GLY A 142
LEU A  76
ILE A 131
MET A 127
MET A  63
 None
 1.20A 3adsA-4qfuA:
undetectable		 3adsA-4qfuA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq7 PUTATIVE STRINGENT
STARVATION PROTEIN A

(Burkholderia
cenocepacia) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 GLU A 109
GLY A 167
ARG A 128
ILE A 127
MET A 178
 GSH  A 301 ( 4.6A)
None
None
None
None
 1.27A 3adsA-4qq7A:
undetectable		 3adsA-4qq7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN

(Candidatus
Nitrososphaera
gargensis) 		PF00561
(Abhydrolase_1) 		5 GLU A 239
ILE A 261
GLY A 264
LEU A  46
ILE A 120
 None
 1.41A 3adsA-5a62A:
undetectable		 3adsA-5a62A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afd N-ACETYLNEURAMINATE
LYASE

(Aliivibrio
salmonicida) 		PF00701
(DHDPS) 		5 GLU A  57
ARG A 272
GLY A  48
LEU A  33
ILE A  26
 None
GOL  A1301 ( 4.8A)
None
None
None
 1.43A 3adsA-5afdA:
undetectable		 3adsA-5afdA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		5 GLU A 273
ILE A 269
LEU A 357
ILE A 309
MET A 332
 None
 1.04A 3adsA-5c1bA:
undetectable		 3adsA-5c1bA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d04 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		5 GLU C 145
ILE C 234
GLY C 186
ILE C  59
MET C 302
 None
None
None
None
CL  C 404 ( 3.9A)
 1.41A 3adsA-5d04C:
undetectable		 3adsA-5d04C:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ds0 PEPTIDASE M42

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF05343
(Peptidase_M42) 		5 GLU A  69
GLY A 176
LEU A 333
ILE A 183
MET A   7
 None
 1.34A 3adsA-5ds0A:
undetectable		 3adsA-5ds0A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du2 ESPG2
GLYCOSYLTRANSFERASE

(Actinomadura
verrucosospora) 		PF00201
(UDPGT) 		5 GLU A 356
ARG A 353
GLY A 351
CYH A 251
MET A 264
 None
 1.43A 3adsA-5du2A:
undetectable		 3adsA-5du2A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep0 PUTATIVE REPRESSOR
PROTEIN LUXO

(Photobacterium
angustum) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 GLU A  92
ARG A  95
ILE A  94
GLY A  97
ILE A  80
 None
 1.22A 3adsA-5ep0A:
undetectable		 3adsA-5ep0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep0 PUTATIVE REPRESSOR
PROTEIN LUXO

(Photobacterium
angustum) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 GLU A  92
ILE A  94
GLY A  97
LEU A  50
ILE A  80
 None
 1.15A 3adsA-5ep0A:
undetectable		 3adsA-5ep0A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLU A  58
ILE A  85
GLY A  84
ILE A  50
MET A 339
 None
None
EDO  A1871 ( 4.6A)
None
None
 1.35A 3adsA-5fjiA:
undetectable		 3adsA-5fjiA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 GLU A 161
ILE A 178
LEU A 197
ILE A 157
MET A 130
 None
 1.41A 3adsA-5fqdA:
undetectable		 3adsA-5fqdA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP1
VP3

(Deformed wing
virus) 		PF00073
(Rhv)
PF08762
(CRPV_capsid) 		5 GLU C  51
ARG C  61
ILE C  58
GLY A  98
MET C 113
 None
 1.44A 3adsA-5g52C:
undetectable		 3adsA-5g52C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		5 GLU A 162
ARG A 665
ILE A 666
LEU A  72
MET A 108
 None
 1.22A 3adsA-5hmpA:
undetectable		 3adsA-5hmpA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 ILE A  14
GLY A  16
ILE A  97
MET A 292
MET A  33
 None
 1.44A 3adsA-5l1bA:
undetectable		 3adsA-5l1bA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva DNA REPAIR HELICASE
RAD3

(Saccharomyces
cerevisiae) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 GLU Y 640
GLY Y 415
CYH Y 439
ARG Y 436
ILE Y 634
 None
 1.45A 3adsA-5svaY:
undetectable		 3adsA-5svaY:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN

(Arthrospira
maxima) 		PF02136
(NTF2)
PF09150
(Carot_N) 		5 GLU A 255
ILE A 192
GLY A 257
LEU A 294
MET A 204
 None
 1.48A 3adsA-5ui2A:
undetectable		 3adsA-5ui2A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE

(Sulfurisphaera
tokodaii) 		no annotation 5 GLU A 157
ARG A  99
GLY A 152
ARG A 205
ILE A 209
 None
 1.50A 3adsA-5uxgA:
undetectable		 3adsA-5uxgA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4a GLYCOSYLTRANSFERASE
(DUF1792)

(Streptococcus
sanguinis) 		PF08759
(GT-D) 		5 GLU A 248
ARG A 116
GLY A  29
LEU A  50
ILE A  41
 None
UDP  A 301 (-4.1A)
None
None
None
 1.26A 3adsA-5v4aA:
undetectable		 3adsA-5v4aA:
22.19