SIMILAR PATTERNS OF AMINO ACIDS FOR 3ABM_W_CHDW1060

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aih HP1 INTEGRASE

(Haemophilus
virus HP1) 		PF00589
(Phage_integrase) 		4 ILE A 239
LEU A 243
THR A 215
LEU A 214
 None
None
SO4  A 109 (-4.1A)
None
 0.91A 3abmN-1aihA:
undetectable
3abmW-1aihA:
0.0		 3abmN-1aihA:
15.90
3abmW-1aihA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1j PROFILIN II

(Homo sapiens) 		PF00235
(Profilin) 		4 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.91A 3abmN-1d1jA:
undetectable
3abmW-1d1jA:
undetectable		 3abmN-1d1jA:
15.87
3abmW-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		4 ILE A 350
MET A 311
THR A 312
LEU A 315
 None
 0.85A 3abmN-1floA:
0.2
3abmW-1floA:
0.0		 3abmN-1floA:
21.78
3abmW-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.72A 3abmN-1harA:
undetectable
3abmW-1harA:
0.0		 3abmN-1harA:
18.00
3abmW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		4 LEU A 261
PHE A 262
THR A 230
LEU A 229
 None
 0.88A 3abmN-1ihpA:
0.0
3abmW-1ihpA:
0.0		 3abmN-1ihpA:
21.69
3abmW-1ihpA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.99A 3abmN-1jedA:
0.0
3abmW-1jedA:
0.0		 3abmN-1jedA:
21.17
3abmW-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus musculus) 		PF00855
(PWWP) 		4 TYR A 305
ARG A 306
MET A 309
LEU A 313
 None
 0.89A 3abmN-1khcA:
undetectable
3abmW-1khcA:
undetectable		 3abmN-1khcA:
13.81
3abmW-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A  53
PHE A 104
ARG A 138
THR A 142
LEU A 144
 None
 1.40A 3abmN-1knrA:
3.7
3abmW-1knrA:
0.0		 3abmN-1knrA:
20.83
3abmW-1knrA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.82A 3abmN-1kt8A:
0.0
3abmW-1kt8A:
0.0		 3abmN-1kt8A:
22.71
3abmW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2m REP PROTEIN

(Tomato yellow
leaf curl
Sardinia virus) 		PF00799
(Gemini_AL1) 		4 ILE A   9
PHE A   7
THR A  17
LEU A  16
 None
 0.88A 3abmN-1l2mA:
undetectable
3abmW-1l2mA:
undetectable		 3abmN-1l2mA:
10.72
3abmW-1l2mA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxt PHOSPHOGLUCOMUTASE
(DEPHOSPHO FORM)

(Oryctolagus
cuniculus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A  42
PHE A  38
THR A 114
LEU A 113
 None
 0.80A 3abmN-1lxtA:
0.0
3abmW-1lxtA:
undetectable		 3abmN-1lxtA:
21.38
3abmW-1lxtA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI

(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1)
PF14528
(LAGLIDADG_3) 		4 ILE A  18
PHE A  91
ARG A  55
MET A  56
 None
None
SO4  A 271 (-3.1A)
None
 0.91A 3abmN-1mowA:
0.0
3abmW-1mowA:
undetectable		 3abmN-1mowA:
18.60
3abmW-1mowA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw5 HYPOTHETICAL PROTEIN
HI1480

(Haemophilus
influenzae) 		no annotation 5 ILE A 135
LEU A  62
PHE A 131
THR A  32
LEU A  34
 None
 1.32A 3abmN-1mw5A:
undetectable
3abmW-1mw5A:
undetectable		 3abmN-1mw5A:
15.69
3abmW-1mw5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no8 ALY

(Mus musculus) 		PF00076
(RRM_1) 		5 ILE A 121
LEU A 124
PHE A 125
MET A 175
LEU A 170
 None
 1.26A 3abmN-1no8A:
undetectable
3abmW-1no8A:
undetectable		 3abmN-1no8A:
11.24
3abmW-1no8A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		5 ILE A 335
LEU A 339
TYR A 310
ARG A 328
THR A 312
 None
None
None
HG  A 614 ( 4.9A)
None
 1.27A 3abmN-1pm2A:
undetectable
3abmW-1pm2A:
undetectable		 3abmN-1pm2A:
19.19
3abmW-1pm2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ILE A 666
MET A 736
THR A 734
LEU A 733
 None
 0.92A 3abmN-1qf7A:
undetectable
3abmW-1qf7A:
undetectable		 3abmN-1qf7A:
21.37
3abmW-1qf7A:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.99A 3abmN-1r6xA:
undetectable
3abmW-1r6xA:
undetectable		 3abmN-1r6xA:
21.48
3abmW-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		4 LEU A 261
PHE A 262
THR A 230
LEU A 229
 None
 0.82A 3abmN-1skaA:
undetectable
3abmW-1skaA:
undetectable		 3abmN-1skaA:
19.89
3abmW-1skaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdh NEI ENDONUCLEASE
VIII-LIKE 1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		4 ILE A  47
LEU A 112
PHE A 101
LEU A  56
 None
 0.92A 3abmN-1tdhA:
undetectable
3abmW-1tdhA:
undetectable		 3abmN-1tdhA:
20.00
3abmW-1tdhA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tex STF0
SULFOTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF09037
(Sulphotransf) 		4 ILE A  86
PHE A  38
ARG A 129
LEU A 116
 None
 0.89A 3abmN-1texA:
undetectable
3abmW-1texA:
undetectable		 3abmN-1texA:
18.62
3abmW-1texA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		5 ILE A 361
PHE A 287
ARG A 310
MET A 294
THR A 295
 None
 1.49A 3abmN-1v43A:
undetectable
3abmW-1v43A:
undetectable		 3abmN-1v43A:
21.39
3abmW-1v43A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00215
(OMPdecase) 		4 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.80A 3abmN-1vqtA:
undetectable
3abmW-1vqtA:
undetectable		 3abmN-1vqtA:
17.18
3abmW-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ILE A 250
LEU A 253
ARG A 211
LEU A 204
 None
 0.79A 3abmN-1w1kA:
undetectable
3abmW-1w1kA:
undetectable		 3abmN-1w1kA:
22.15
3abmW-1w1kA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn0 HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN

(Zea mays) 		PF01627
(Hpt) 		5 LEU A  30
PHE A  27
MET A 134
THR A 133
LEU A 135
 None
 1.40A 3abmN-1wn0A:
2.8
3abmW-1wn0A:
undetectable		 3abmN-1wn0A:
13.04
3abmW-1wn0A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 ILE A 192
LEU A 273
PHE A 274
LEU A 211
 None
 0.84A 3abmN-1xl8A:
2.4
3abmW-1xl8A:
undetectable		 3abmN-1xl8A:
19.90
3abmW-1xl8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C) 		4 ILE B 365
PHE B 366
THR B 268
LEU B 267
 None
 0.90A 3abmN-1y8qB:
3.2
3abmW-1y8qB:
undetectable		 3abmN-1y8qB:
21.77
3abmW-1y8qB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE

(Moorella
thermoacetica) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ILE A 367
LEU A 340
ARG A 305
LEU A 277
 None
 0.87A 3abmN-1ycgA:
undetectable
3abmW-1ycgA:
undetectable		 3abmN-1ycgA:
22.05
3abmW-1ycgA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		4 ILE X 178
LEU X 181
ARG X  95
LEU X 102
 None
 0.88A 3abmN-1zv4X:
undetectable
3abmW-1zv4X:
undetectable		 3abmN-1zv4X:
13.67
3abmW-1zv4X:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyp ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F

(Salmonella
enterica) 		PF13192
(Thioredoxin_3) 		4 ILE A  67
LEU A  23
THR A  18
LEU A  17
 None
 0.88A 3abmN-1zypA:
undetectable
3abmW-1zypA:
undetectable		 3abmN-1zypA:
16.98
3abmW-1zypA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 LEU A 227
TYR A  72
THR A  77
LEU A  80
 None
 0.68A 3abmN-2b9bA:
undetectable
3abmW-2b9bA:
2.6		 3abmN-2b9bA:
21.63
3abmW-2b9bA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		4 LEU A  39
PHE A  37
ARG A  21
LEU A  15
 None
 0.88A 3abmN-2cfoA:
undetectable
3abmW-2cfoA:
undetectable		 3abmN-2cfoA:
21.24
3abmW-2cfoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36

(Mus musculus) 		PF11605
(Vps36_ESCRT-II) 		5 ILE A  82
LEU A 108
PHE A 110
ARG A 120
LEU A  42
 None
 1.22A 3abmN-2dx5A:
undetectable
3abmW-2dx5A:
undetectable		 3abmN-2dx5A:
12.45
3abmW-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		4 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 3abmN-2eg5A:
undetectable
3abmW-2eg5A:
undetectable		 3abmN-2eg5A:
22.14
3abmW-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fej CELLULAR TUMOR
ANTIGEN P53

(Homo sapiens) 		PF00870
(P53) 		5 ILE A 255
LEU A 111
PHE A 270
TYR A 236
THR A 140
 None
 1.47A 3abmN-2fejA:
undetectable
3abmW-2fejA:
undetectable		 3abmN-2fejA:
15.09
3abmW-2fejA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		5 ILE A 118
PHE A 126
MET A 167
THR A 165
LEU A 164
 None
 1.43A 3abmN-2g9bA:
undetectable
3abmW-2g9bA:
undetectable		 3abmN-2g9bA:
16.24
3abmW-2g9bA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350

(Human
gammaherpesvirus
4) 		PF05109
(Herpes_BLLF1) 		4 PHE A  52
ARG A 107
THR A 105
LEU A 104
 None
 0.88A 3abmN-2h6oA:
undetectable
3abmW-2h6oA:
undetectable		 3abmN-2h6oA:
23.02
3abmW-2h6oA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.76A 3abmN-2hnzA:
undetectable
3abmW-2hnzA:
undetectable		 3abmN-2hnzA:
19.77
3abmW-2hnzA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE A   9
ARG A 108
THR A  43
LEU A  42
 None
 0.88A 3abmN-2idcA:
undetectable
3abmW-2idcA:
undetectable		 3abmN-2idcA:
13.97
3abmW-2idcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzn MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT

(Escherichia
coli) 		PF03610
(EIIA-man) 		4 ILE A   3
LEU A 114
PHE A 111
LEU A  65
 None
 0.86A 3abmN-2jznA:
undetectable
3abmW-2jznA:
undetectable		 3abmN-2jznA:
15.94
3abmW-2jznA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.80A 3abmN-2kbqA:
undetectable
3abmW-2kbqA:
undetectable		 3abmN-2kbqA:
8.84
3abmW-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxw CALMODULIN

(Paramecium
tetraurelia) 		PF13499
(EF-hand_7) 		4 PHE A  89
MET A 109
THR A 110
LEU A 116
 None
 0.90A 3abmN-2kxwA:
undetectable
3abmW-2kxwA:
undetectable		 3abmN-2kxwA:
8.77
3abmW-2kxwA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la7 UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF03724
(META) 		4 LEU A 112
ARG A 117
THR A 137
LEU A 138
 None
 0.90A 3abmN-2la7A:
undetectable
3abmW-2la7A:
undetectable		 3abmN-2la7A:
14.14
3abmW-2la7A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lez SECRETED EFFECTOR
PROTEIN PIPB2

(Salmonella
enterica) 		no annotation 4 PHE A 124
MET A  61
THR A  60
LEU A  57
 None
 0.92A 3abmN-2lezA:
undetectable
3abmW-2lezA:
undetectable		 3abmN-2lezA:
13.68
3abmW-2lezA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 ILE A 142
LEU A 117
THR A  38
LEU A  39
 None
 0.92A 3abmN-2m6kA:
undetectable
3abmW-2m6kA:
undetectable		 3abmN-2m6kA:
18.83
3abmW-2m6kA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.76A 3abmN-2p0dA:
undetectable
3abmW-2p0dA:
undetectable		 3abmN-2p0dA:
12.67
3abmW-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE X 252
MET X 356
THR X 357
LEU X 360
 None
 0.82A 3abmN-2p3gX:
undetectable
3abmW-2p3gX:
undetectable		 3abmN-2p3gX:
19.81
3abmW-2p3gX:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 LEU A 128
PHE A 137
TYR A  58
LEU A 163
 None
 0.79A 3abmN-2p3xA:
undetectable
3abmW-2p3xA:
undetectable		 3abmN-2p3xA:
19.17
3abmW-2p3xA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 ILE A 175
PHE A 177
ARG A 165
LEU A 130
 None
 0.86A 3abmN-2qbyA:
undetectable
3abmW-2qbyA:
undetectable		 3abmN-2qbyA:
20.30
3abmW-2qbyA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjw UNCHARACTERIZED
PROTEIN XCC1541

(Xanthomonas
campestris) 		no annotation 4 ILE A 121
LEU A  99
THR A 106
LEU A 114
 None
 0.92A 3abmN-2qjwA:
undetectable
3abmW-2qjwA:
undetectable		 3abmN-2qjwA:
16.20
3abmW-2qjwA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ILE A 272
PHE A 203
THR A  16
LEU A  17
 None
 0.90A 3abmN-2qk4A:
undetectable
3abmW-2qk4A:
undetectable		 3abmN-2qk4A:
22.52
3abmW-2qk4A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 ILE A 689
LEU A 826
THR A 808
LEU A 809
 None
 0.87A 3abmN-2r6fA:
undetectable
3abmW-2r6fA:
undetectable		 3abmN-2r6fA:
19.77
3abmW-2r6fA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 PHE A 347
MET A 334
THR A 335
LEU A 336
 None
 0.88A 3abmN-2uvfA:
undetectable
3abmW-2uvfA:
undetectable		 3abmN-2uvfA:
22.56
3abmW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 ILE A 480
LEU A 517
PHE A 520
ARG A 395
LEU A 543
 None
 1.12A 3abmN-2w1zA:
undetectable
3abmW-2w1zA:
undetectable		 3abmN-2w1zA:
20.08
3abmW-2w1zA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 4 LEU 1  84
PHE 1 156
THR 1 198
LEU 1 197
 None
 0.89A 3abmN-2ws91:
undetectable
3abmW-2ws91:
undetectable		 3abmN-2ws91:
19.07
3abmW-2ws91:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		4 LEU C 309
ARG C 345
THR C 423
LEU C 424
 None
 0.76A 3abmN-2wy0C:
undetectable
3abmW-2wy0C:
undetectable		 3abmN-2wy0C:
21.21
3abmW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 ILE A 695
PHE A 728
THR A 757
LEU A 758
 None
 0.92A 3abmN-2x2iA:
undetectable
3abmW-2x2iA:
undetectable		 3abmN-2x2iA:
18.50
3abmW-2x2iA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE

(Aeromonas
salmonicida) 		PF14521
(Aspzincin_M35) 		4 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.83A 3abmN-2x3cA:
1.2
3abmW-2x3cA:
undetectable		 3abmN-2x3cA:
20.64
3abmW-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		4 ILE A 301
LEU A 304
PHE A 305
LEU A 373
 None
 0.92A 3abmN-2xutA:
1.9
3abmW-2xutA:
undetectable		 3abmN-2xutA:
23.16
3abmW-2xutA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		5 LEU A 244
PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.06A 3abmN-2xxlA:
undetectable
3abmW-2xxlA:
undetectable		 3abmN-2xxlA:
19.17
3abmW-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 ILE A  75
LEU A  77
THR A  60
LEU A  59
 None
 0.72A 3abmN-2y24A:
undetectable
3abmW-2y24A:
undetectable		 3abmN-2y24A:
22.63
3abmW-2y24A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		5 TYR J  32
ARG J  33
MET J  36
THR J  37
LEU J  40
 None
 0.49A 3abmN-2y69J:
undetectable
3abmW-2y69J:
8.0		 3abmN-2y69J:
10.31
3abmW-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ILE A 617
PHE A 646
THR A 606
LEU A 635
 None
 0.83A 3abmN-2yheA:
undetectable
3abmW-2yheA:
undetectable		 3abmN-2yheA:
20.41
3abmW-2yheA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.91A 3abmN-2z7xB:
undetectable
3abmW-2z7xB:
undetectable		 3abmN-2z7xB:
23.01
3abmW-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A 193
LEU A  97
PHE A 196
MET A 184
 None
 0.74A 3abmN-2ze0A:
undetectable
3abmW-2ze0A:
undetectable		 3abmN-2ze0A:
19.59
3abmW-2ze0A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgk ANTI-TUMOR LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.91A 3abmN-2zgkA:
undetectable
3abmW-2zgkA:
undetectable		 3abmN-2zgkA:
15.56
3abmW-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		4 TYR A 471
MET A 475
THR A 476
LEU A 479
 None
 0.70A 3abmN-2ziuA:
undetectable
3abmW-2ziuA:
undetectable		 3abmN-2ziuA:
18.55
3abmW-2ziuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.88A 3abmN-2zsgA:
2.6
3abmW-2zsgA:
undetectable		 3abmN-2zsgA:
20.79
3abmW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.69A 3abmN-2ztsA:
undetectable
3abmW-2ztsA:
undetectable		 3abmN-2ztsA:
17.81
3abmW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 352
LEU A 377
THR A 348
LEU A 372
 None
 0.81A 3abmN-3b2dA:
undetectable
3abmW-3b2dA:
undetectable		 3abmN-3b2dA:
20.65
3abmW-3b2dA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 ILE A 343
LEU A 347
PHE A 344
LEU A 396
 None
 0.84A 3abmN-3b46A:
undetectable
3abmW-3b46A:
undetectable		 3abmN-3b46A:
22.55
3abmW-3b46A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 ILE A  66
ARG A 100
THR A  42
LEU A  43
 None
 0.84A 3abmN-3b4uA:
undetectable
3abmW-3b4uA:
undetectable		 3abmN-3b4uA:
20.99
3abmW-3b4uA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b57 LIN1889 PROTEIN

(Listeria
innocua) 		PF01966
(HD) 		4 ILE A  30
PHE A  18
THR A  73
LEU A  76
 None
 0.87A 3abmN-3b57A:
undetectable
3abmW-3b57A:
undetectable		 3abmN-3b57A:
16.01
3abmW-3b57A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.37A 3abmN-3b7yA:
undetectable
3abmW-3b7yA:
undetectable		 3abmN-3b7yA:
13.39
3abmW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 312
TYR A 261
THR A 289
LEU A 346
 None
 0.87A 3abmN-3bn1A:
undetectable
3abmW-3bn1A:
undetectable		 3abmN-3bn1A:
21.12
3abmW-3bn1A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
LEU A  62
ARG A  73
LEU A 200
 None
 0.80A 3abmN-3c9bA:
undetectable
3abmW-3c9bA:
undetectable		 3abmN-3c9bA:
16.41
3abmW-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 LEU A  53
PHE A  50
ARG A  77
LEU A 115
 None
 0.82A 3abmN-3dbyA:
1.9
3abmW-3dbyA:
undetectable		 3abmN-3dbyA:
17.09
3abmW-3dbyA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 LEU A  30
PHE A  32
TYR A 255
THR A 271
 None
 0.81A 3abmN-3dcpA:
undetectable
3abmW-3dcpA:
undetectable		 3abmN-3dcpA:
19.37
3abmW-3dcpA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0s UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF05235
(CHAD) 		4 PHE A 255
TYR A 347
MET A 351
THR A 352
 None
 0.89A 3abmN-3e0sA:
2.9
3abmW-3e0sA:
undetectable		 3abmN-3e0sA:
19.13
3abmW-3e0sA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 ILE A 230
LEU A 231
THR A 219
LEU A 255
 None
 0.84A 3abmN-3e7fA:
undetectable
3abmW-3e7fA:
undetectable		 3abmN-3e7fA:
19.65
3abmW-3e7fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 5 ILE A 784
PHE A 747
ARG A 721
MET A 720
LEU A 718
 None
 1.43A 3abmN-3f95A:
undetectable
3abmW-3f95A:
undetectable		 3abmN-3f95A:
17.88
3abmW-3f95A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		4 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.88A 3abmN-3fddA:
undetectable
3abmW-3fddA:
undetectable		 3abmN-3fddA:
21.01
3abmW-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.86A 3abmN-3fg4A:
undetectable
3abmW-3fg4A:
undetectable		 3abmN-3fg4A:
20.56
3abmW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ILE A 200
MET A 158
THR A 159
LEU A 160
 None
 0.91A 3abmN-3fssA:
undetectable
3abmW-3fssA:
undetectable		 3abmN-3fssA:
19.04
3abmW-3fssA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		5 LEU A 216
TYR A  68
MET A 105
THR A 104
LEU A 103
 None
 1.48A 3abmN-3gf6A:
undetectable
3abmW-3gf6A:
undetectable		 3abmN-3gf6A:
19.49
3abmW-3gf6A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 ILE A 131
MET A 159
THR A 160
LEU A 163
 None
 0.88A 3abmN-3gjuA:
undetectable
3abmW-3gjuA:
undetectable		 3abmN-3gjuA:
22.26
3abmW-3gjuA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 165
LEU B  48
ARG B  31
LEU B  36
 None
 0.82A 3abmN-3gzyB:
undetectable
3abmW-3gzyB:
undetectable		 3abmN-3gzyB:
15.34
3abmW-3gzyB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 ILE A 147
LEU A 152
THR A 331
LEU A 332
 None
 0.76A 3abmN-3h5tA:
undetectable
3abmW-3h5tA:
undetectable		 3abmN-3h5tA:
21.02
3abmW-3h5tA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7a SHORT CHAIN
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00106
(adh_short) 		4 ILE A 135
PHE A 137
THR A  70
LEU A  73
 ILE  A 135 ( 0.6A)
PHE  A 137 ( 1.3A)
THR  A  70 ( 0.8A)
LEU  A  73 ( 0.5A)
 0.86A 3abmN-3h7aA:
undetectable
3abmW-3h7aA:
undetectable		 3abmN-3h7aA:
18.89
3abmW-3h7aA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A  15
ARG A  37
THR A  50
LEU A  51
 None
 0.87A 3abmN-3hi8A:
undetectable
3abmW-3hi8A:
undetectable		 3abmN-3hi8A:
20.53
3abmW-3hi8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjc HEAT SHOCK PROTEIN
83-1

(Leishmania
major) 		PF00183
(HSP90) 		4 ILE A 157
TYR A 146
THR A 184
LEU A 185
 None
 0.91A 3abmN-3hjcA:
undetectable
3abmW-3hjcA:
undetectable		 3abmN-3hjcA:
18.41
3abmW-3hjcA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn5 PUTATIVE EXPORTED
PROTEIN BF0290

(Bacteroides
fragilis) 		PF12866
(DUF3823) 		4 ILE A 105
ARG A  36
THR A  34
LEU A  33
 None
 0.80A 3abmN-3hn5A:
undetectable
3abmW-3hn5A:
undetectable		 3abmN-3hn5A:
17.12
3abmW-3hn5A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		5 ILE A  66
LEU A  37
PHE A  68
THR A 262
LEU A 260
 None
 1.07A 3abmN-3ix1A:
undetectable
3abmW-3ix1A:
undetectable		 3abmN-3ix1A:
19.80
3abmW-3ix1A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 ILE A 374
LEU A 249
ARG A 245
LEU A 317
 None
 0.84A 3abmN-3j4pA:
undetectable
3abmW-3j4pA:
undetectable		 3abmN-3j4pA:
22.36
3abmW-3j4pA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2

(Saccharomyces
cerevisiae) 		PF05916
(Sld5) 		4 ILE B 188
LEU B 192
ARG B 182
LEU B 168
 None
 0.92A 3abmN-3jc7B:
undetectable
3abmW-3jc7B:
undetectable		 3abmN-3jc7B:
16.60
3abmW-3jc7B:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		4 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.86A 3abmN-3jzdA:
undetectable
3abmW-3jzdA:
undetectable		 3abmN-3jzdA:
22.15
3abmW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ARG A 407
MET A 410
THR A 411
LEU A 414
 None
 0.71A 3abmN-3k13A:
undetectable
3abmW-3k13A:
undetectable		 3abmN-3k13A:
20.20
3abmW-3k13A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.87A 3abmN-3k1rA:
undetectable
3abmW-3k1rA:
undetectable		 3abmN-3k1rA:
14.45
3abmW-3k1rA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.79A 3abmN-3kuqA:
undetectable
3abmW-3kuqA:
undetectable		 3abmN-3kuqA:
17.51
3abmW-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyj CHEY6 PROTEIN

(Rhodobacter
sphaeroides) 		PF00072
(Response_reg) 		4 ILE B   7
MET B 128
THR B 127
LEU B 124
 None
 0.84A 3abmN-3kyjB:
undetectable
3abmW-3kyjB:
undetectable		 3abmN-3kyjB:
15.09
3abmW-3kyjB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		5 ILE A 180
LEU A 192
PHE A 194
ARG A 201
LEU A 207
 None
 1.30A 3abmN-3kzxA:
undetectable
3abmW-3kzxA:
undetectable		 3abmN-3kzxA:
17.44
3abmW-3kzxA:
11.26