SIMILAR PATTERNS OF AMINO ACIDS FOR 3ABL_P_CHDP1271_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 GLN A 383
PHE A  31
PHE A 386
LEU A 332
 None
 1.12A 3ablP-1c4oA:
undetectable
3ablW-1c4oA:
0.0		 3ablP-1c4oA:
16.59
3ablW-1c4oA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		4 GLN A 460
PHE A 367
LEU A 365
PHE A 422
 None
 1.14A 3ablP-1cu1A:
0.2
3ablW-1cu1A:
0.0		 3ablP-1cu1A:
18.31
3ablW-1cu1A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN

(Mus musculus) 		PF06482
(Endostatin) 		4 GLN A 165
PHE A 166
PHE A 152
PHE A 159
 None
 0.95A 3ablP-1dy2A:
undetectable
3ablW-1dy2A:
undetectable		 3ablP-1dy2A:
22.82
3ablW-1dy2A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		4 GLN A  10
PHE A  13
LEU A 125
PHE A 129
 None
 1.14A 3ablP-1ecoA:
undetectable
3ablW-1ecoA:
0.0		 3ablP-1ecoA:
20.00
3ablW-1ecoA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.12A 3ablP-1fdjA:
undetectable
3ablW-1fdjA:
0.0		 3ablP-1fdjA:
18.85
3ablW-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkm PROTEIN (GYP1P)

(Saccharomyces
cerevisiae) 		PF00566
(RabGAP-TBC) 		4 GLN A 603
PHE A 479
LEU A 488
PHE A 492
 None
 1.16A 3ablP-1fkmA:
0.0
3ablW-1fkmA:
0.0		 3ablP-1fkmA:
20.41
3ablW-1fkmA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		4 GLN A 115
PHE A 121
LEU A 123
PHE A 106
 None
 1.05A 3ablP-1gkrA:
undetectable
3ablW-1gkrA:
0.0		 3ablP-1gkrA:
18.57
3ablW-1gkrA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		4 PHE A 441
PHE A 361
LEU A 365
PHE A 367
 None
None
None
ADP  A1756 (-3.3A)
 1.07A 3ablP-1gm5A:
2.9
3ablW-1gm5A:
0.0		 3ablP-1gm5A:
15.64
3ablW-1gm5A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5x GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Thermotoga
maritima) 		PF01380
(SIS) 		4 PHE A  93
PHE A  95
LEU A  54
PHE A 152
 None
 1.12A 3ablP-1j5xA:
undetectable
3ablW-1j5xA:
0.0		 3ablP-1j5xA:
21.80
3ablW-1j5xA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		4 GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.05A 3ablP-1oltA:
0.0
3ablW-1oltA:
undetectable		 3ablP-1oltA:
20.00
3ablW-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 GLN A 295
PHE A 293
PHE A 297
PHE A 468
 None
 1.13A 3ablP-1r6uA:
undetectable
3ablW-1r6uA:
undetectable		 3ablP-1r6uA:
17.83
3ablW-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 GLN A 304
PHE A 187
LEU A 183
PHE A 179
 None
 1.12A 3ablP-1r6uA:
undetectable
3ablW-1r6uA:
undetectable		 3ablP-1r6uA:
17.83
3ablW-1r6uA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svr SEVERIN

(Dictyostelium
discoideum) 		PF00626
(Gelsolin) 		4 GLN A 200
PHE A 201
PHE A 245
LEU A 249
 None
 0.89A 3ablP-1svrA:
undetectable
3ablW-1svrA:
undetectable		 3ablP-1svrA:
17.37
3ablW-1svrA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdq AGGRECAN CORE
PROTEIN

(Rattus
norvegicus) 		PF00059
(Lectin_C) 		4 GLN B  80
PHE B  81
LEU B  62
PHE B  71
 None
 1.17A 3ablP-1tdqB:
undetectable
3ablW-1tdqB:
undetectable		 3ablP-1tdqB:
14.23
3ablW-1tdqB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		4 PHE A  98
PHE A  56
LEU A  68
PHE A  70
 None
 1.17A 3ablP-1vfnA:
undetectable
3ablW-1vfnA:
undetectable		 3ablP-1vfnA:
24.03
3ablW-1vfnA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ARG A 533
PHE A 490
LEU A 478
PHE A 480
 None
 1.13A 3ablP-1w93A:
undetectable
3ablW-1w93A:
undetectable		 3ablP-1w93A:
18.93
3ablW-1w93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xho CHORISMATE MUTASE

(Ruminiclostridium
thermocellum) 		PF07736
(CM_1) 		4 ARG A  62
GLN A  24
PHE A  46
LEU A  71
 None
 0.86A 3ablP-1xhoA:
undetectable
3ablW-1xhoA:
undetectable		 3ablP-1xhoA:
17.72
3ablW-1xhoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywq NITROREDUCTASE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		4 GLN A 150
PHE A  64
LEU A  99
PHE A 101
 None
 1.07A 3ablP-1ywqA:
undetectable
3ablW-1ywqA:
undetectable		 3ablP-1ywqA:
21.40
3ablW-1ywqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 GLN A 297
PHE A 296
PHE A 329
LEU A 303
 None
 1.10A 3ablP-1zb7A:
undetectable
3ablW-1zb7A:
undetectable		 3ablP-1zb7A:
18.67
3ablW-1zb7A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		4 ARG H 119
GLN H 142
PHE H 143
PHE H  66
 None
 0.97A 3ablP-2bbkH:
undetectable
3ablW-2bbkH:
undetectable		 3ablP-2bbkH:
20.44
3ablW-2bbkH:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF13833
(EF-hand_8) 		4 PHE C 148
PHE C 132
LEU C 113
PHE C 100
 None
 1.15A 3ablP-2bl0C:
undetectable
3ablW-2bl0C:
undetectable		 3ablP-2bl0C:
21.40
3ablW-2bl0C:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czo BUD EMERGENCE
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00787
(PX) 		4 PHE A 300
PHE A 321
LEU A 396
PHE A 397
 None
 1.14A 3ablP-2czoA:
undetectable
3ablW-2czoA:
undetectable		 3ablP-2czoA:
20.61
3ablW-2czoA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6l LECTIN, GALACTOSE
BINDING, SOLUBLE 9

(Mus musculus) 		PF00337
(Gal-bind_lectin) 		4 GLN X  89
PHE X  92
LEU X 100
PHE X 102
 None
 1.17A 3ablP-2d6lX:
undetectable
3ablW-2d6lX:
undetectable		 3ablP-2d6lX:
21.43
3ablW-2d6lX:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3j RNA AND EXPORT
FACTOR BINDING
PROTEIN 2

(Mus musculus) 		PF00076
(RRM_1)
PF07078
(FYTT) 		4 GLN A 134
PHE A  98
PHE A  95
LEU A  77
 None
 1.13A 3ablP-2f3jA:
undetectable
3ablW-2f3jA:
undetectable		 3ablP-2f3jA:
21.85
3ablW-2f3jA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jnu REGULATOR OF
G-PROTEIN SIGNALING
14

(Homo sapiens) 		PF00615
(RGS) 		4 ARG A  85
GLN A 108
PHE A  43
LEU A  73
 None
 1.13A 3ablP-2jnuA:
3.0
3ablW-2jnuA:
undetectable		 3ablP-2jnuA:
22.63
3ablW-2jnuA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		4 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.13A 3ablP-2nyfA:
2.2
3ablW-2nyfA:
undetectable		 3ablP-2nyfA:
17.96
3ablW-2nyfA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A
TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		4 PHE A  99
PHE B   9
LEU B  14
PHE B  18
 None
 0.98A 3ablP-2p1nA:
undetectable
3ablW-2p1nA:
undetectable		 3ablP-2p1nA:
18.58
3ablW-2p1nA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD

(Lactobacillus
paracasei) 		PF04909
(Amidohydro_2) 		4 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.17A 3ablP-2qpxA:
undetectable
3ablW-2qpxA:
undetectable		 3ablP-2qpxA:
20.58
3ablW-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 1.04A 3ablP-2r4gA:
undetectable
3ablW-2r4gA:
undetectable		 3ablP-2r4gA:
19.66
3ablW-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		4 GLN A 347
PHE A 348
PHE A 345
PHE A 309
 None
None
None
MTY  A 300 ( 3.9A)
 1.09A 3ablP-2tohA:
undetectable
3ablW-2tohA:
undetectable		 3ablP-2tohA:
21.19
3ablW-2tohA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w0i TWINFILIN-2

(Homo sapiens) 		PF00241
(Cofilin_ADF) 		4 PHE A 255
PHE A 238
LEU A 190
PHE A 287
 None
 1.03A 3ablP-2w0iA:
undetectable
3ablW-2w0iA:
undetectable		 3ablP-2w0iA:
19.83
3ablW-2w0iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1z ROP2

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 GLN A 533
PHE A 520
LEU A 476
PHE A 410
 None
 1.13A 3ablP-2w1zA:
2.8
3ablW-2w1zA:
undetectable		 3ablP-2w1zA:
21.68
3ablW-2w1zA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfu CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		no annotation 4 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 0.89A 3ablP-2yfuA:
undetectable
3ablW-2yfuA:
undetectable		 3ablP-2yfuA:
19.85
3ablW-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLN A 344
PHE A 342
LEU A 385
PHE A 387
 None
 1.12A 3ablP-2z63A:
undetectable
3ablW-2z63A:
undetectable		 3ablP-2z63A:
18.51
3ablW-2z63A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 GLN A 235
PHE A 251
LEU A 249
PHE A 247
 None
 1.17A 3ablP-3a3iA:
undetectable
3ablW-3a3iA:
undetectable		 3ablP-3a3iA:
20.00
3ablW-3a3iA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 ARG A 200
GLN A 208
PHE A 182
LEU A 184
 None
None
MRD  A 305 (-4.4A)
None
 1.00A 3ablP-3ailA:
undetectable
3ablW-3ailA:
undetectable		 3ablP-3ailA:
20.54
3ablW-3ailA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay5 CYCLIN-D1-BINDING
PROTEIN 1

(Homo sapiens) 		PF13324
(GCIP) 		4 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.97A 3ablP-3ay5A:
3.7
3ablW-3ay5A:
undetectable		 3ablP-3ay5A:
21.94
3ablW-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 4 GLN A  87
PHE A 121
PHE A  45
LEU A  18
 None
 0.99A 3ablP-3ba3A:
undetectable
3ablW-3ba3A:
undetectable		 3ablP-3ba3A:
21.19
3ablW-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgh PUTATIVE
NEURAMINYLLACTOSE-BI
NDING HEMAGGLUTININ
HOMOLOG

(Helicobacter
pylori) 		PF05211
(NLBH) 		4 GLN A  78
PHE A  81
PHE A  44
LEU A  42
 None
 1.01A 3ablP-3bghA:
2.1
3ablW-3bghA:
undetectable		 3ablP-3bghA:
19.22
3ablW-3bghA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjb PROBABLE
TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 GLN A  42
PHE A  68
LEU A  67
PHE A  61
 None
 1.11A 3ablP-3bjbA:
3.2
3ablW-3bjbA:
undetectable		 3ablP-3bjbA:
20.75
3ablW-3bjbA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		4 ARG H 172
GLN H 195
PHE H 196
PHE H 119
 None
 0.88A 3ablP-3c75H:
undetectable
3ablW-3c75H:
undetectable		 3ablP-3c75H:
19.95
3ablW-3c75H:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foc TRYPTOPHANYL-TRNA
SYNTHETASE

(Giardia
intestinalis) 		PF00579
(tRNA-synt_1b) 		4 ARG A 161
GLN A 108
PHE A 148
LEU A 428
 None
 1.18A 3ablP-3focA:
undetectable
3ablW-3focA:
undetectable		 3ablP-3focA:
19.12
3ablW-3focA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
GLN A 193
PHE A 196
PHE A 153
 None
 0.92A 3ablP-3g1zA:
undetectable
3ablW-3g1zA:
undetectable		 3ablP-3g1zA:
20.94
3ablW-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ARG X1280
GLN X1121
PHE X1120
LEU X1126
 None
 1.10A 3ablP-3jb9X:
undetectable
3ablW-3jb9X:
undetectable		 3ablP-3jb9X:
11.15
3ablW-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 491
GLN A 505
PHE A 504
LEU A 406
 None
 1.15A 3ablP-3k4xA:
undetectable
3ablW-3k4xA:
undetectable		 3ablP-3k4xA:
14.85
3ablW-3k4xA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llb UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03471
(CorC_HlyC) 		4 PHE A  61
PHE A  63
LEU A  41
PHE A  35
 None
 1.10A 3ablP-3llbA:
undetectable
3ablW-3llbA:
undetectable		 3ablP-3llbA:
15.22
3ablW-3llbA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PHE A 327
PHE A 299
LEU A 296
PHE A 294
 None
 1.07A 3ablP-3ogrA:
undetectable
3ablW-3ogrA:
undetectable		 3ablP-3ogrA:
14.48
3ablW-3ogrA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 PHE A  11
PHE A  21
LEU A  25
PHE A  29
 EDO  A 320 (-4.5A)
None
None
None
 1.14A 3ablP-3ooxA:
undetectable
3ablW-3ooxA:
undetectable		 3ablP-3ooxA:
19.64
3ablW-3ooxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 GLN A 101
PHE A 102
PHE A  98
LEU A  64
 None
 1.08A 3ablP-3op1A:
undetectable
3ablW-3op1A:
undetectable		 3ablP-3op1A:
19.18
3ablW-3op1A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pao ADENOSINE DEAMINASE

(Pseudomonas
aeruginosa) 		PF00962
(A_deaminase) 		4 PHE A 158
PHE A 162
LEU A 137
PHE A 139
 None
 1.18A 3ablP-3paoA:
undetectable
3ablW-3paoA:
undetectable		 3ablP-3paoA:
20.29
3ablW-3paoA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Bacillus cereus) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		4 PHE A 130
PHE A 148
LEU A  94
PHE A  83
 None
 1.15A 3ablP-3q4iA:
3.5
3ablW-3q4iA:
undetectable		 3ablP-3q4iA:
20.44
3ablW-3q4iA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr8 OLIGORIBONUCLEASE

(Coxiella
burnetii) 		PF00929
(RNase_T) 		4 ARG A 113
GLN A 111
LEU A 104
PHE A 127
 None
 1.11A 3ablP-3tr8A:
undetectable
3ablW-3tr8A:
undetectable		 3ablP-3tr8A:
20.07
3ablW-3tr8A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3

(Saccharomyces
cerevisiae) 		PF08639
(SLD3) 		4 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 0.92A 3ablP-3wi3A:
2.6
3ablW-3wi3A:
undetectable		 3ablP-3wi3A:
18.93
3ablW-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6o ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		4 GLN A1276
PHE A1275
PHE A1268
LEU A1266
 None
 1.12A 3ablP-4a6oA:
undetectable
3ablW-4a6oA:
undetectable		 3ablP-4a6oA:
19.10
3ablW-4a6oA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)

(Pyrococcus
furiosus) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM) 		4 GLN A 132
PHE A 158
LEU A 129
PHE A 176
 None
 1.05A 3ablP-4aefA:
undetectable
3ablW-4aefA:
undetectable		 3ablP-4aefA:
19.49
3ablW-4aefA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 GLN A2252
PHE A2251
LEU A2196
PHE A2192
 None
 1.04A 3ablP-4c0dA:
2.5
3ablW-4c0dA:
undetectable		 3ablP-4c0dA:
14.62
3ablW-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyl EFF-1A

(Caenorhabditis
elegans) 		PF14884
(EFF-AFF) 		4 GLN A  43
PHE A  44
PHE A 381
LEU A 379
 None
 1.02A 3ablP-4cylA:
undetectable
3ablW-4cylA:
undetectable		 3ablP-4cylA:
18.62
3ablW-4cylA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0o A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00621
(RhoGEF) 		4 GLN A2008
PHE A2011
PHE A2057
LEU A2061
 None
 0.76A 3ablP-4d0oA:
3.5
3ablW-4d0oA:
undetectable		 3ablP-4d0oA:
17.79
3ablW-4d0oA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6

(Homo sapiens) 		PF01398
(JAB)
PF13012
(MitMem_reg) 		4 GLN F 111
PHE F 112
PHE F  87
LEU F  89
 None
 1.15A 3ablP-4d10F:
undetectable
3ablW-4d10F:
3.3		 3ablP-4d10F:
21.26
3ablW-4d10F:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE

(Pantoea
ananatis) 		PF01593
(Amino_oxidase) 		4 GLN A 103
PHE A 183
LEU A 179
PHE A 113
 None
 1.16A 3ablP-4dgkA:
undetectable
3ablW-4dgkA:
undetectable		 3ablP-4dgkA:
19.15
3ablW-4dgkA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpz HRAS-LIKE SUPPRESSOR
2

(Homo sapiens) 		PF04970
(LRAT) 		4 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 1.08A 3ablP-4dpzX:
undetectable
3ablW-4dpzX:
undetectable		 3ablP-4dpzX:
18.93
3ablW-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP

(Plasmodium
falciparum) 		PF00092
(VWA) 		4 ARG A 176
GLN A 169
PHE A 198
LEU A 202
 None
 1.04A 3ablP-4hqfA:
undetectable
3ablW-4hqfA:
undetectable		 3ablP-4hqfA:
20.74
3ablW-4hqfA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 GLN A 276
PHE A 312
LEU A 308
PHE A 267
 None
 1.08A 3ablP-4i1aA:
2.8
3ablW-4i1aA:
undetectable		 3ablP-4i1aA:
22.11
3ablW-4i1aA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 PHE A 180
PHE A 177
LEU A 158
PHE A 160
 None
 1.06A 3ablP-4j72A:
undetectable
3ablW-4j72A:
undetectable		 3ablP-4j72A:
22.37
3ablW-4j72A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ARG A 484
GLN A 133
PHE A 134
LEU A 479
 None
 1.00A 3ablP-4jsoA:
undetectable
3ablW-4jsoA:
undetectable		 3ablP-4jsoA:
18.63
3ablW-4jsoA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN

(Chaetomium
thermophilum) 		PF04840
(Vps16_C) 		4 GLN B 756
PHE B 753
PHE B 769
LEU B 765
 None
 0.96A 3ablP-4kmoB:
undetectable
3ablW-4kmoB:
undetectable		 3ablP-4kmoB:
19.53
3ablW-4kmoB:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.14A 3ablP-4l60A:
undetectable
3ablW-4l60A:
undetectable		 3ablP-4l60A:
21.54
3ablW-4l60A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		4 GLN A 230
PHE A 154
LEU A 152
PHE A 149
 None
 1.13A 3ablP-4llfA:
undetectable
3ablW-4llfA:
undetectable		 3ablP-4llfA:
21.36
3ablW-4llfA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8n PLEXINC1
INTRACELLULAR REGION

(Danio rerio) 		PF08337
(Plexin_cytopl) 		4 GLN A1114
PHE A 653
LEU A 657
PHE A 663
 None
 1.02A 3ablP-4m8nA:
undetectable
3ablW-4m8nA:
undetectable		 3ablP-4m8nA:
16.89
3ablW-4m8nA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 245
PHE A 269
LEU A 273
PHE A 277
 None
 1.06A 3ablP-4n5cA:
3.6
3ablW-4n5cA:
undetectable		 3ablP-4n5cA:
14.04
3ablW-4n5cA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 GLN A 375
PHE A 372
LEU A 299
PHE A 301
 None
 0.98A 3ablP-4oyaA:
undetectable
3ablW-4oyaA:
undetectable		 3ablP-4oyaA:
19.62
3ablW-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pii N-GLYCOSYLASE/DNA
LYASE

(Pyrococcus
furiosus) 		PF09171
(AGOG) 		4 GLN A  31
PHE A  34
PHE A  42
PHE A 153
 CL  A 306 (-4.4A)
None
None
None
 1.11A 3ablP-4piiA:
undetectable
3ablW-4piiA:
undetectable		 3ablP-4piiA:
18.15
3ablW-4piiA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qqb UPSTREAM OF N-RAS,
ISOFORM A

(Drosophila
melanogaster) 		PF00313
(CSD) 		4 ARG X  59
GLN X  36
PHE X  32
PHE X  31
 C  P  14 ( 3.0A)
None
None
A  P  15 ( 3.4A)
 0.98A 3ablP-4qqbX:
undetectable
3ablW-4qqbX:
undetectable		 3ablP-4qqbX:
14.58
3ablW-4qqbX:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		4 ARG A 428
GLN A 403
PHE A  89
LEU A  90
 None
B12  A 803 (-3.7A)
None
None
 1.11A 3ablP-4rasA:
undetectable
3ablW-4rasA:
undetectable		 3ablP-4rasA:
15.49
3ablW-4rasA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE

(Geobacillus
thermodenitrificans) 		no annotation 4 GLN A 251
PHE A 250
PHE A 332
LEU A 257
 None
 1.09A 3ablP-4rh0A:
undetectable
3ablW-4rh0A:
undetectable		 3ablP-4rh0A:
22.46
3ablW-4rh0A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		4 GLN A 245
PHE A 336
LEU A 333
PHE A 268
 None
 1.10A 3ablP-4rslA:
undetectable
3ablW-4rslA:
undetectable		 3ablP-4rslA:
18.68
3ablW-4rslA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 ARG A  27
PHE A  50
PHE A  35
LEU A  34
 None
 1.02A 3ablP-4wpxA:
undetectable
3ablW-4wpxA:
undetectable		 3ablP-4wpxA:
21.84
3ablW-4wpxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13549
(ATP-grasp_5) 		4 PHE B 146
PHE B 142
LEU B 173
PHE B 177
 None
 1.13A 3ablP-4xymB:
undetectable
3ablW-4xymB:
undetectable		 3ablP-4xymB:
18.66
3ablW-4xymB:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zox RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 4 GLN A 383
PHE A 349
LEU A 365
PHE A 360
 None
 1.08A 3ablP-4zoxA:
undetectable
3ablW-4zoxA:
undetectable		 3ablP-4zoxA:
22.88
3ablW-4zoxA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		4 PHE A  93
PHE A  85
LEU A 130
PHE A 123
 None
 0.98A 3ablP-5b4sA:
undetectable
3ablW-5b4sA:
undetectable		 3ablP-5b4sA:
22.65
3ablW-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 GLN A 460
PHE A 459
PHE A 378
LEU A 343
 None
 0.79A 3ablP-5bzaA:
undetectable
3ablW-5bzaA:
undetectable		 3ablP-5bzaA:
17.12
3ablW-5bzaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9h TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 0.92A 3ablP-5c9hA:
undetectable
3ablW-5c9hA:
undetectable		 3ablP-5c9hA:
18.61
3ablW-5c9hA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6p PLEXIN-B2

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 GLN A1803
PHE A1336
LEU A1340
PHE A1346
 None
 1.14A 3ablP-5e6pA:
2.3
3ablW-5e6pA:
undetectable		 3ablP-5e6pA:
16.96
3ablW-5e6pA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLN A 518
PHE A 517
LEU A 586
PHE A 588
 None
 1.18A 3ablP-5fr8A:
undetectable
3ablW-5fr8A:
undetectable		 3ablP-5fr8A:
16.67
3ablW-5fr8A:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guw NITRIC OXIDE
REDUCTASE SUBUNIT C

(Pseudomonas
aeruginosa) 		PF00034
(Cytochrom_C) 		4 GLN A  96
PHE A  94
PHE A  91
LEU A 129
 None
 1.17A 3ablP-5guwA:
undetectable
3ablW-5guwA:
undetectable		 3ablP-5guwA:
18.01
3ablW-5guwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 GLN A 370
PHE A 371
PHE A 506
LEU A 504
 None
 1.15A 3ablP-5h42A:
3.3
3ablW-5h42A:
undetectable		 3ablP-5h42A:
12.60
3ablW-5h42A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 PHE A 174
PHE A 101
LEU A  97
PHE A  92
 None
 1.06A 3ablP-5huuA:
undetectable
3ablW-5huuA:
undetectable		 3ablP-5huuA:
19.58
3ablW-5huuA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 PHE A 182
PHE A 109
LEU A 105
PHE A 100
 None
 1.03A 3ablP-5hvmA:
undetectable
3ablW-5hvmA:
undetectable		 3ablP-5hvmA:
18.38
3ablW-5hvmA:
8.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		5 ARG C 156
GLN C 161
PHE C 164
PHE C 219
LEU C 223
 CHD  C 307 (-4.0A)
CHD  C 307 (-4.3A)
CHD  C 307 (-3.9A)
None
None
 0.33A 3ablP-5iy5C:
37.3
3ablW-5iy5C:
undetectable		 3ablP-5iy5C:
100.00
3ablW-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdm MAJOR TEGUMENT
PROTEIN

(Human
gammaherpesvirus
4) 		PF12818
(Tegument_dsDNA) 		4 PHE D 500
PHE D 553
LEU D 551
PHE D 578
 None
 1.17A 3ablP-5kdmD:
undetectable
3ablW-5kdmD:
undetectable		 3ablP-5kdmD:
21.64
3ablW-5kdmD:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 ARG A 124
GLN A 137
PHE A 214
LEU A 204
 None
 1.16A 3ablP-5l56A:
undetectable
3ablW-5l56A:
undetectable		 3ablP-5l56A:
12.46
3ablW-5l56A:
4.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 ARG B 490
GLN B 485
PHE B 482
LEU B 257
 None
 1.15A 3ablP-5ltmB:
3.7
3ablW-5ltmB:
undetectable		 3ablP-5ltmB:
18.82
3ablW-5ltmB:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n9j MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 14

(Schizosaccharomyces
pombe) 		PF08638
(Med14) 		4 GLN A 485
PHE A 556
LEU A 551
PHE A 420
 None
 1.11A 3ablP-5n9jA:
2.8
3ablW-5n9jA:
undetectable		 3ablP-5n9jA:
18.62
3ablW-5n9jA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 4 PHE A 339
PHE A 322
LEU A 326
PHE A 330
 None
 1.01A 3ablP-5oenA:
undetectable
3ablW-5oenA:
undetectable		 3ablP-5oenA:
undetectable
3ablW-5oenA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vai UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF00002
(7tm_2)
PF02793
(HRM) 		4 GLN R 410
PHE R 413
PHE R 169
LEU R 172
 None
 1.09A 3ablP-5vaiR:
undetectable
3ablW-5vaiR:
undetectable		 3ablP-5vaiR:
19.18
3ablW-5vaiR:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5;
Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C)
PF01801
(Cytomega_gL) 		4 PHE A  90
PHE A  80
LEU B 183
PHE B 222
 None
 1.18A 3ablP-5vocA:
2.6
3ablW-5vocA:
undetectable		 3ablP-5vocA:
15.48
3ablW-5vocA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		4 PHE A 380
PHE A 341
LEU A 294
PHE A 278
 None
 1.15A 3ablP-5xcyA:
undetectable
3ablW-5xcyA:
undetectable		 3ablP-5xcyA:
19.83
3ablW-5xcyA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		4 GLN A 233
PHE A 212
LEU A 183
PHE A  81
 None
 1.15A 3ablP-5xwbA:
undetectable
3ablW-5xwbA:
undetectable		 3ablP-5xwbA:
20.54
3ablW-5xwbA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 4 GLN A 378
PHE A 387
LEU A 366
PHE A 649
 None
PGE  A 703 (-4.4A)
EE4  A 701 ( 4.6A)
None
 0.94A 3ablP-6c0tA:
1.9
3ablW-6c0tA:
undetectable		 3ablP-6c0tA:
undetectable
3ablW-6c0tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhm -

(-) 		no annotation 4 GLN A 139
PHE A 140
PHE A 127
LEU A 115
 None
 1.02A 3ablP-6fhmA:
undetectable
3ablW-6fhmA:
undetectable		 3ablP-6fhmA:
undetectable
3ablW-6fhmA:
undetectable