SIMILAR PATTERNS OF AMINO ACIDS FOR 3ABL_C_CHDC271_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 GLN A  17
PHE A 115
LEU A 150
PHE A  65
 None
 1.36A 3ablC-1dppA:
1.4
3ablJ-1dppA:
0.0		 3ablC-1dppA:
20.58
3ablJ-1dppA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 GLN A 370
PHE A  47
LEU A 345
PHE A 341
 None
 1.43A 3ablC-1fc4A:
undetectable
3ablJ-1fc4A:
0.0		 3ablC-1fc4A:
20.10
3ablJ-1fc4A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1) 		4 ARG A  80
GLN A 486
PHE A 491
LEU A 471
 HEM  A1001 (-4.0A)
None
None
None
 1.42A 3ablC-1fftA:
2.0
3ablJ-1fftA:
0.0		 3ablC-1fftA:
16.59
3ablJ-1fftA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkm PROTEIN (GYP1P)

(Saccharomyces
cerevisiae) 		PF00566
(RabGAP-TBC) 		4 GLN A 603
PHE A 479
LEU A 488
PHE A 492
 None
 1.00A 3ablC-1fkmA:
0.0
3ablJ-1fkmA:
0.0		 3ablC-1fkmA:
20.41
3ablJ-1fkmA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		4 GLN A 329
PHE A 332
LEU A 324
PHE A 298
 None
 1.42A 3ablC-1fp9A:
undetectable
3ablJ-1fp9A:
0.0		 3ablC-1fp9A:
19.39
3ablJ-1fp9A:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		4 GLN A  96
PHE A  97
LEU A  84
PHE A  88
 None
 1.36A 3ablC-1gz5A:
undetectable
3ablJ-1gz5A:
0.0		 3ablC-1gz5A:
19.91
3ablJ-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		4 GLN A 320
PHE A 265
LEU A 218
PHE A 214
 None
 1.39A 3ablC-1kfwA:
0.0
3ablJ-1kfwA:
0.0		 3ablC-1kfwA:
19.52
3ablJ-1kfwA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyj GLUTATHIONE
S-TRANSFERASE

(Oryza sativa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 GLN A  19
PHE A  17
LEU A  73
PHE A 164
 None
GSH  A 799 (-4.0A)
None
None
 1.47A 3ablC-1oyjA:
2.5
3ablJ-1oyjA:
0.0		 3ablC-1oyjA:
19.29
3ablJ-1oyjA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLN B 244
PHE B 243
LEU B 210
PHE B 203
 None
 1.30A 3ablC-1qhhB:
undetectable
3ablJ-1qhhB:
0.0		 3ablC-1qhhB:
18.33
3ablJ-1qhhB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rro RAT ONCOMODULIN

(Rattus rattus) 		PF13499
(EF-hand_7) 		4 ARG A  75
GLN A  71
LEU A  77
PHE A  24
 None
CA  A 135 (-3.3A)
None
None
 1.26A 3ablC-1rroA:
undetectable
3ablJ-1rroA:
undetectable		 3ablC-1rroA:
16.14
3ablJ-1rroA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rro RAT ONCOMODULIN

(Rattus rattus) 		PF13499
(EF-hand_7) 		4 ARG A  75
GLN A  71
PHE A  70
LEU A  77
 None
CA  A 135 (-3.3A)
None
None
 1.39A 3ablC-1rroA:
undetectable
3ablJ-1rroA:
undetectable		 3ablC-1rroA:
16.14
3ablJ-1rroA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
LARGE SUBUNIT

(Rhodococcus
jostii) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 GLN A 217
PHE A 213
LEU A 431
PHE A 317
 FE2  A 600 (-3.8A)
None
None
None
 1.34A 3ablC-1uliA:
undetectable
3ablJ-1uliA:
undetectable		 3ablC-1uliA:
19.61
3ablJ-1uliA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 ARG B 984
GLN B 950
PHE B 949
LEU B 942
 None
 1.36A 3ablC-1uw4B:
undetectable
3ablJ-1uw4B:
undetectable		 3ablC-1uw4B:
20.20
3ablJ-1uw4B:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		4 GLN A 943
PHE A 942
LEU A1130
PHE A 985
 None
 1.47A 3ablC-1ux6A:
undetectable
3ablJ-1ux6A:
undetectable		 3ablC-1ux6A:
19.50
3ablJ-1ux6A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyn ARGONAUTE2

(Drosophila
melanogaster) 		PF02170
(PAZ) 		4 ARG A  30
PHE A  14
LEU A  33
PHE A  32
 None
 1.49A 3ablC-1vynA:
undetectable
3ablJ-1vynA:
undetectable		 3ablC-1vynA:
22.73
3ablJ-1vynA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 GLN A  57
PHE A  56
LEU A  89
PHE A  93
 FRU  A 801 (-3.6A)
None
None
NAG  A1001 (-3.8A)
 1.49A 3ablC-1y9gA:
undetectable
3ablJ-1y9gA:
undetectable		 3ablC-1y9gA:
20.90
3ablJ-1y9gA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ARG A 101
PHE A 510
LEU A 105
PHE A 454
 None
 1.42A 3ablC-1yr2A:
undetectable
3ablJ-1yr2A:
undetectable		 3ablC-1yr2A:
16.55
3ablJ-1yr2A:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aug GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14

(Homo sapiens) 		PF00017
(SH2) 		4 GLN A 489
PHE A 488
LEU A 516
PHE A 510
 None
 1.23A 3ablC-2augA:
undetectable
3ablJ-2augA:
undetectable		 3ablC-2augA:
18.68
3ablJ-2augA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		4 ARG H 119
GLN H 142
PHE H 143
PHE H  66
 None
 0.86A 3ablC-2bbkH:
undetectable
3ablJ-2bbkH:
undetectable		 3ablC-2bbkH:
20.44
3ablJ-2bbkH:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH

(Bacillus
subtilis) 		PF07435
(YycH) 		4 GLN A 319
PHE A 320
LEU A 142
PHE A 143
 None
 1.34A 3ablC-2fgtA:
undetectable
3ablJ-2fgtA:
undetectable		 3ablC-2fgtA:
18.53
3ablJ-2fgtA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqy CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF09924
(DUF2156) 		4 GLN A  44
PHE A  54
LEU A  80
PHE A  91
 None
 1.39A 3ablC-2hqyA:
undetectable
3ablJ-2hqyA:
undetectable		 3ablC-2hqyA:
20.62
3ablJ-2hqyA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		4 GLN A 117
PHE A 120
LEU A 133
PHE A 151
 None
 1.00A 3ablC-2in3A:
undetectable
3ablJ-2in3A:
undetectable		 3ablC-2in3A:
22.22
3ablJ-2in3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kb2 BLRP1

(Klebsiella
pneumoniae) 		PF04940
(BLUF) 		4 GLN A  49
PHE A  50
LEU A  98
PHE A 103
 None
FMN  A 149 ( 3.1A)
None
None
 1.31A 3ablC-2kb2A:
undetectable
3ablJ-2kb2A:
undetectable		 3ablC-2kb2A:
20.31
3ablJ-2kb2A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m8h RNA-BINDING PROTEIN
7

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLN A  58
PHE A  59
LEU A  33
PHE A  37
 None
 1.43A 3ablC-2m8hA:
undetectable
3ablJ-2m8hA:
undetectable		 3ablC-2m8hA:
15.04
3ablJ-2m8hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		4 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.15A 3ablC-2nyfA:
2.3
3ablJ-2nyfA:
undetectable		 3ablC-2nyfA:
17.96
3ablJ-2nyfA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaa R.MVAI

(Kocuria varians) 		PF15515
(MvaI_BcnI) 		4 GLN A 155
PHE A 229
LEU A 190
PHE A 187
 None
 1.46A 3ablC-2oaaA:
undetectable
3ablJ-2oaaA:
undetectable		 3ablC-2oaaA:
20.00
3ablJ-2oaaA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD

(Lactobacillus
paracasei) 		PF04909
(Amidohydro_2) 		4 GLN A  10
PHE A   7
LEU A 336
PHE A 332
 None
 1.24A 3ablC-2qpxA:
undetectable
3ablJ-2qpxA:
undetectable		 3ablC-2qpxA:
20.58
3ablJ-2qpxA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 0.89A 3ablC-2r4gA:
undetectable
3ablJ-2r4gA:
undetectable		 3ablC-2r4gA:
19.66
3ablJ-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4g TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 391
PHE A 398
LEU A 459
PHE A 307
 BR  A   5 ( 4.6A)
None
None
None
 1.31A 3ablC-2r4gA:
undetectable
3ablJ-2r4gA:
undetectable		 3ablC-2r4gA:
19.66
3ablJ-2r4gA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		4 GLN A 329
PHE A 332
LEU A 324
PHE A 298
 None
 1.44A 3ablC-2x1iA:
undetectable
3ablJ-2x1iA:
undetectable		 3ablC-2x1iA:
20.12
3ablJ-2x1iA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xi7 RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF15518
(L_protein_N) 		4 GLN A 166
PHE A 162
LEU A  29
PHE A   9
 None
 1.45A 3ablC-2xi7A:
2.2
3ablJ-2xi7A:
undetectable		 3ablC-2xi7A:
20.39
3ablJ-2xi7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 ARG A 557
PHE A 523
LEU A 510
PHE A 480
 None
 1.17A 3ablC-2xswA:
undetectable
3ablJ-2xswA:
undetectable		 3ablC-2xswA:
21.62
3ablJ-2xswA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 GLN A 344
PHE A 342
LEU A 385
PHE A 387
 None
 1.04A 3ablC-2z63A:
undetectable
3ablJ-2z63A:
undetectable		 3ablC-2z63A:
18.51
3ablJ-2z63A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcq BETA-CHAIN
HEMOGLOBIN

(Brycon cephalus) 		PF00042
(Globin) 		4 GLN B 132
PHE B 134
LEU B  14
PHE B 118
 None
 1.31A 3ablC-3bcqB:
undetectable
3ablJ-3bcqB:
undetectable		 3ablC-3bcqB:
20.90
3ablJ-3bcqB:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN

(Paracoccus
versutus) 		PF06433
(Me-amine-dh_H) 		4 ARG H 172
GLN H 195
PHE H 196
PHE H 119
 None
 0.78A 3ablC-3c75H:
undetectable
3ablJ-3c75H:
undetectable		 3ablC-3c75H:
19.95
3ablJ-3c75H:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 GLN A 218
PHE A 217
LEU A 194
PHE A 193
 None
 1.47A 3ablC-3ciyA:
undetectable
3ablJ-3ciyA:
undetectable		 3ablC-3ciyA:
15.20
3ablJ-3ciyA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ciy TOLL-LIKE RECEPTOR 3

(Mus musculus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 GLN A 352
PHE A 351
LEU A 321
PHE A 294
 None
 1.33A 3ablC-3ciyA:
undetectable
3ablJ-3ciyA:
undetectable		 3ablC-3ciyA:
15.20
3ablJ-3ciyA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmn PUTATIVE HYDROLASE

(Chloroflexus
aurantiacus) 		PF10103
(Zincin_2) 		4 GLN A 118
PHE A 120
LEU A 232
PHE A 228
 None
 0.99A 3ablC-3cmnA:
1.9
3ablJ-3cmnA:
undetectable		 3ablC-3cmnA:
21.80
3ablJ-3cmnA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ef1 RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		4 GLN A 265
PHE A 264
LEU A 285
PHE A 286
 None
 1.30A 3ablC-3ef1A:
undetectable
3ablJ-3ef1A:
undetectable		 3ablC-3ef1A:
18.95
3ablJ-3ef1A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 GLN A1325
PHE A1324
LEU A1244
PHE A1221
 None
 1.42A 3ablC-3f5fA:
undetectable
3ablJ-3f5fA:
undetectable		 3ablC-3f5fA:
15.17
3ablJ-3f5fA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 GLN A1325
PHE A1324
LEU A1244
PHE A1316
 None
 1.33A 3ablC-3f5fA:
undetectable
3ablJ-3f5fA:
undetectable		 3ablC-3f5fA:
15.17
3ablJ-3f5fA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLN A 286
PHE A 284
LEU A 241
PHE A 239
 None
 1.28A 3ablC-3fhtA:
undetectable
3ablJ-3fhtA:
undetectable		 3ablC-3fhtA:
20.16
3ablJ-3fhtA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
GLN A 193
PHE A 215
LEU A 162
 None
 1.40A 3ablC-3g1zA:
undetectable
3ablJ-3g1zA:
undetectable		 3ablC-3g1zA:
20.94
3ablJ-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		4 GLN A 232
PHE A 233
LEU A 251
PHE A 269
 None
 1.24A 3ablC-3gs3A:
undetectable
3ablJ-3gs3A:
undetectable		 3ablC-3gs3A:
19.29
3ablJ-3gs3A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdn SERINE/THREONINE-PRO
TEIN KINASE SGK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 167
PHE A 166
LEU A 162
PHE A 241
 None
 1.27A 3ablC-3hdnA:
2.3
3ablJ-3hdnA:
undetectable		 3ablC-3hdnA:
22.31
3ablJ-3hdnA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf8 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 GLN A 288
PHE A 289
LEU A 281
PHE A 250
 None
 1.35A 3ablC-3hf8A:
undetectable
3ablJ-3hf8A:
undetectable		 3ablC-3hf8A:
21.23
3ablJ-3hf8A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ARG X1280
GLN X1121
PHE X1120
LEU X1126
 None
 1.10A 3ablC-3jb9X:
undetectable
3ablJ-3jb9X:
undetectable		 3ablC-3jb9X:
11.15
3ablJ-3jb9X:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 491
GLN A 505
PHE A 504
LEU A 406
 None
 1.14A 3ablC-3k4xA:
undetectable
3ablJ-3k4xA:
undetectable		 3ablC-3k4xA:
14.85
3ablJ-3k4xA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kf3 INVERTASE

(Schwanniomyces
occidentalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 GLN A  68
PHE A  67
LEU A 308
PHE A 298
 FRU  A 600 (-4.0A)
None
None
None
 1.15A 3ablC-3kf3A:
undetectable
3ablJ-3kf3A:
undetectable		 3ablC-3kf3A:
19.12
3ablJ-3kf3A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLN A 237
PHE A 209
LEU A 200
PHE A 246
 None
 1.22A 3ablC-3kw7A:
undetectable
3ablJ-3kw7A:
undetectable		 3ablC-3kw7A:
19.01
3ablJ-3kw7A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkr COATOMER SUBUNIT
EPSILON

(Bos taurus) 		PF04733
(Coatomer_E) 		4 ARG A  97
GLN A 131
PHE A 128
LEU A  91
 None
 1.44A 3ablC-3mkrA:
undetectable
3ablJ-3mkrA:
undetectable		 3ablC-3mkrA:
20.83
3ablJ-3mkrA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2i UNCHARACTERIZED
PROTEIN

(Leptospirillum
rubarum) 		no annotation 4 GLN A  44
PHE A  43
LEU A  62
PHE A  68
 None
 1.29A 3ablC-3o2iA:
undetectable
3ablJ-3o2iA:
undetectable		 3ablC-3o2iA:
19.16
3ablJ-3o2iA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr8 OLIGORIBONUCLEASE

(Coxiella
burnetii) 		PF00929
(RNase_T) 		4 ARG A 113
GLN A 111
LEU A 104
PHE A 127
 None
 1.12A 3ablC-3tr8A:
undetectable
3ablJ-3tr8A:
undetectable		 3ablC-3tr8A:
20.07
3ablJ-3tr8A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4v TELOMERASE-ASSOCIATE
D PROTEIN 82

(Tetrahymena
thermophila) 		PF01336
(tRNA_anti-codon) 		4 GLN A 292
PHE A 293
LEU A 299
PHE A 230
 None
 1.30A 3ablC-3u4vA:
undetectable
3ablJ-3u4vA:
undetectable		 3ablC-3u4vA:
16.35
3ablJ-3u4vA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubd RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		4 GLN A 138
PHE A 137
LEU A 133
PHE A 212
 None
None
None
SL0  A 400 ( 4.5A)
 1.29A 3ablC-3ubdA:
undetectable
3ablJ-3ubdA:
undetectable		 3ablC-3ubdA:
22.60
3ablJ-3ubdA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi3 DNA REPLICATION
REGULATOR SLD3

(Saccharomyces
cerevisiae) 		PF08639
(SLD3) 		4 GLN A 415
PHE A 412
LEU A 398
PHE A 393
 None
 1.10A 3ablC-3wi3A:
1.7
3ablJ-3wi3A:
undetectable		 3ablC-3wi3A:
18.93
3ablJ-3wi3A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 GLN A2252
PHE A2251
LEU A2196
PHE A2192
 None
 0.93A 3ablC-4c0dA:
4.2
3ablJ-4c0dA:
undetectable		 3ablC-4c0dA:
14.62
3ablJ-4c0dA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Corynebacterium
diphtheriae) 		PF01625
(PMSR) 		4 ARG A  90
GLN A 134
PHE A  73
LEU A  17
 None
 1.41A 3ablC-4d7lA:
undetectable
3ablJ-4d7lA:
undetectable		 3ablC-4d7lA:
19.85
3ablJ-4d7lA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etz PELD

(Pseudomonas
aeruginosa) 		PF13492
(GAF_3)
PF16963
(PelD_GGDEF) 		4 ARG A 404
GLN A 426
LEU A 417
PHE A 407
 None
 1.44A 3ablC-4etzA:
undetectable
3ablJ-4etzA:
undetectable		 3ablC-4etzA:
21.43
3ablJ-4etzA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqn MALCAVERNIN

(Homo sapiens) 		PF16545
(CCM2_C) 		4 ARG A 354
PHE A 348
LEU A 369
PHE A 365
 None
 1.41A 3ablC-4fqnA:
undetectable
3ablJ-4fqnA:
undetectable		 3ablC-4fqnA:
14.18
3ablJ-4fqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gu3 OUTER CAPSID PROTEIN
SIGMA-1

(Mammalian
orthoreovirus) 		PF01664
(Reo_sigma1) 		4 GLN A 344
PHE A 383
LEU A 441
PHE A 387
 None
 1.44A 3ablC-4gu3A:
undetectable
3ablJ-4gu3A:
undetectable		 3ablC-4gu3A:
23.27
3ablJ-4gu3A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 GLN B 129
PHE B 132
LEU B  83
PHE B  79
 None
 1.25A 3ablC-4i6mB:
undetectable
3ablJ-4i6mB:
undetectable		 3ablC-4i6mB:
18.30
3ablJ-4i6mB:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il2 STARVATION SENSING
PROTEIN RSPA

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLN A 150
PHE A 154
LEU A 221
PHE A 246
 None
 1.29A 3ablC-4il2A:
undetectable
3ablJ-4il2A:
undetectable		 3ablC-4il2A:
19.59
3ablJ-4il2A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imi SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		4 GLN A 232
PHE A 233
LEU A 251
PHE A 269
 None
 1.32A 3ablC-4imiA:
undetectable
3ablJ-4imiA:
undetectable		 3ablC-4imiA:
19.53
3ablJ-4imiA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ARG A 484
GLN A 133
PHE A 134
LEU A 479
 None
 0.98A 3ablC-4jsoA:
undetectable
3ablJ-4jsoA:
undetectable		 3ablC-4jsoA:
18.63
3ablJ-4jsoA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 ARG A 645
GLN A 325
PHE A 433
LEU A 411
 None
 1.25A 3ablC-4ka8A:
4.2
3ablJ-4ka8A:
undetectable		 3ablC-4ka8A:
16.02
3ablJ-4ka8A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.13A 3ablC-4l60A:
undetectable
3ablJ-4l60A:
undetectable		 3ablC-4l60A:
21.54
3ablJ-4l60A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odb OUTER CAPSID PROTEIN
SIGMA-1

(Mammalian
orthoreovirus) 		PF01664
(Reo_sigma1) 		4 GLN A 344
PHE A 383
LEU A 441
PHE A 387
 None
 1.44A 3ablC-4odbA:
undetectable
3ablJ-4odbA:
undetectable		 3ablC-4odbA:
19.22
3ablJ-4odbA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 GLN A 375
PHE A 372
LEU A 299
PHE A 301
 None
 1.01A 3ablC-4oyaA:
undetectable
3ablJ-4oyaA:
undetectable		 3ablC-4oyaA:
19.62
3ablJ-4oyaA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 GLN A 741
PHE A 742
LEU A 718
PHE A 714
 None
 1.43A 3ablC-4ppmA:
undetectable
3ablJ-4ppmA:
undetectable		 3ablC-4ppmA:
14.00
3ablJ-4ppmA:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		4 GLN A 333
PHE A 328
LEU A 361
PHE A 121
 None
 1.47A 3ablC-4rjzA:
undetectable
3ablJ-4rjzA:
undetectable		 3ablC-4rjzA:
20.57
3ablJ-4rjzA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8d SORCIN

(Homo sapiens) 		PF13405
(EF-hand_6)
PF13833
(EF-hand_8) 		4 ARG A  76
GLN A  55
PHE A  70
LEU A  77
 None
 1.35A 3ablC-4u8dA:
undetectable
3ablJ-4u8dA:
undetectable		 3ablC-4u8dA:
21.98
3ablJ-4u8dA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubs PENTALENIC ACID
SYNTHASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 ARG A 293
GLN A 350
PHE A 344
LEU A 291
 HEM  A 501 (-2.9A)
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.7A)
 1.48A 3ablC-4ubsA:
undetectable
3ablJ-4ubsA:
undetectable		 3ablC-4ubsA:
21.09
3ablJ-4ubsA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueg GLYCOGENIN-2

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		4 ARG A 119
GLN A 142
PHE A 141
LEU A 185
 None
 1.43A 3ablC-4uegA:
undetectable
3ablJ-4uegA:
undetectable		 3ablC-4uegA:
21.54
3ablJ-4uegA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6) 		4 GLN A 192
PHE A 193
LEU A 185
PHE A 154
 None
 1.09A 3ablC-4uzyA:
undetectable
3ablJ-4uzyA:
undetectable		 3ablC-4uzyA:
16.95
3ablJ-4uzyA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xc5 OUTER CAPSID PROTEIN
SIGMA-1

(Mammalian
orthoreovirus) 		PF01664
(Reo_sigma1) 		4 GLN A 344
PHE A 383
LEU A 441
PHE A 387
 None
 1.46A 3ablC-4xc5A:
undetectable
3ablJ-4xc5A:
undetectable		 3ablC-4xc5A:
19.54
3ablJ-4xc5A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c98 AGAP007691-PB

(Anopheles
gambiae) 		PF00079
(Serpin) 		4 GLN A 131
PHE A 130
LEU A 180
PHE A 330
 None
 1.24A 3ablC-5c98A:
undetectable
3ablJ-5c98A:
undetectable		 3ablC-5c98A:
20.20
3ablJ-5c98A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9h TELOMERASE REVERSE
TRANSCRIPTASE

(Tetrahymena
thermophila) 		PF12009
(Telomerase_RBD) 		4 GLN A 382
PHE A 379
LEU A 405
PHE A 401
 None
 0.77A 3ablC-5c9hA:
undetectable
3ablJ-5c9hA:
undetectable		 3ablC-5c9hA:
18.61
3ablJ-5c9hA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLN A 518
PHE A 517
LEU A 586
PHE A 588
 None
 1.15A 3ablC-5fr8A:
undetectable
3ablJ-5fr8A:
undetectable		 3ablC-5fr8A:
16.67
3ablJ-5fr8A:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 GLN A2252
PHE A2251
LEU A2196
PHE A2192
 None
 1.06A 3ablC-5fu7A:
2.8
3ablJ-5fu7A:
undetectable		 3ablC-5fu7A:
18.30
3ablJ-5fu7A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g26 INTIMIN

(Escherichia
coli) 		PF11924
(IAT_beta) 		4 GLN A 406
PHE A 407
LEU A 228
PHE A 230
 None
None
None
97M  A1452 ( 3.7A)
 1.40A 3ablC-5g26A:
undetectable
3ablJ-5g26A:
undetectable		 3ablC-5g26A:
21.75
3ablJ-5g26A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		4 ARG A 176
GLN A 178
LEU A 158
PHE A 288
 None
 1.29A 3ablC-5gzaA:
2.6
3ablJ-5gzaA:
undetectable		 3ablC-5gzaA:
21.02
3ablJ-5gzaA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 4 ARG A 284
GLN A 292
PHE A 293
LEU A 568
 None
 1.27A 3ablC-5h3kA:
undetectable
3ablJ-5h3kA:
undetectable		 3ablC-5h3kA:
18.17
3ablJ-5h3kA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 ARG A 198
PHE A 170
LEU A 194
PHE A 222
 None
 1.29A 3ablC-5ijbA:
undetectable
3ablJ-5ijbA:
undetectable		 3ablC-5ijbA:
16.33
3ablJ-5ijbA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		4 ARG A 291
GLN A 302
PHE A 301
PHE A 287
 None
 1.23A 3ablC-5iw7A:
undetectable
3ablJ-5iw7A:
undetectable		 3ablC-5iw7A:
16.60
3ablJ-5iw7A:
6.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		4 ARG C 156
GLN C 161
PHE C 164
LEU C 223
 CHD  C 307 (-4.0A)
CHD  C 307 (-4.3A)
CHD  C 307 (-3.9A)
None
 0.25A 3ablC-5iy5C:
37.3
3ablJ-5iy5C:
undetectable		 3ablC-5iy5C:
100.00
3ablJ-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxm PRIB

(Streptomyces
sp. RM-5-8) 		PF11991
(Trp_DMAT) 		4 GLN A 261
PHE A 265
LEU A 333
PHE A  99
 None
 1.36A 3ablC-5jxmA:
undetectable
3ablJ-5jxmA:
undetectable		 3ablC-5jxmA:
21.17
3ablJ-5jxmA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l01 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 GLN A 288
PHE A 289
LEU A 281
PHE A 250
 None
 1.37A 3ablC-5l01A:
undetectable
3ablJ-5l01A:
undetectable		 3ablC-5l01A:
19.02
3ablJ-5l01A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm8 'MULTICOPPER OXIDASE

(Aspergillus
niger) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLN A 211
PHE A 210
LEU A 214
PHE A  79
 None
 1.48A 3ablC-5lm8A:
undetectable
3ablJ-5lm8A:
undetectable		 3ablC-5lm8A:
19.31
3ablJ-5lm8A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 245
PHE A 244
LEU A 342
PHE A 255
 None
 1.34A 3ablC-5lxdA:
1.8
3ablJ-5lxdA:
undetectable		 3ablC-5lxdA:
18.90
3ablJ-5lxdA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens) 		no annotation 4 GLN A 300
PHE A 286
LEU A 423
PHE A 427
 None
 1.39A 3ablC-5m3xA:
undetectable
3ablJ-5m3xA:
undetectable		 3ablC-5m3xA:
undetectable
3ablJ-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 4 GLN B 482
PHE B 479
LEU B 950
PHE B 118
 None
 1.27A 3ablC-5nd1B:
undetectable
3ablJ-5nd1B:
undetectable		 3ablC-5nd1B:
undetectable
3ablJ-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 GLN T3718
PHE T3719
LEU T3645
PHE T3641
 None
 1.08A 3ablC-5ojsT:
undetectable
3ablJ-5ojsT:
undetectable		 3ablC-5ojsT:
5.12
3ablJ-5ojsT:
1.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ARG A 123
GLN A 125
PHE A 132
LEU A  66
 None
 1.38A 3ablC-5opjA:
undetectable
3ablJ-5opjA:
undetectable		 3ablC-5opjA:
undetectable
3ablJ-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		4 ARG A 210
GLN A 143
LEU A 148
PHE A 202
 None
 1.39A 3ablC-5vn6A:
undetectable
3ablJ-5vn6A:
undetectable		 3ablC-5vn6A:
21.55
3ablJ-5vn6A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3r LUXR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		no annotation 4 GLN A 141
PHE A 144
LEU A  79
PHE A  75
 None
None
None
7Y3  A 601 (-4.3A)
 0.87A 3ablC-5x3rA:
undetectable
3ablJ-5x3rA:
undetectable		 3ablC-5x3rA:
undetectable
3ablJ-5x3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 4 GLN A 305
PHE A 304
LEU A 402
PHE A 315
 None
 1.26A 3ablC-5y86A:
undetectable
3ablJ-5y86A:
undetectable		 3ablC-5y86A:
undetectable
3ablJ-5y86A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zut PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.21A 3ablC-5zutA:
undetectable
3ablJ-5zutA:
undetectable		 3ablC-5zutA:
undetectable
3ablJ-5zutA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 4 GLN C 438
PHE C 434
LEU C 418
PHE C 417
 None
 1.04A 3ablC-6c08C:
3.8
3ablJ-6c08C:
undetectable		 3ablC-6c08C:
undetectable
3ablJ-6c08C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fjy PROTEIN CSUE

(Acinetobacter
baumannii) 		no annotation 4 GLN D  28
PHE D 106
LEU D 173
PHE D  59
 None
 1.40A 3ablC-6fjyD:
undetectable
3ablJ-6fjyD:
undetectable		 3ablC-6fjyD:
undetectable
3ablJ-6fjyD:
undetectable