SIMILAR PATTERNS OF AMINO ACIDS FOR 3ABK_W_CHDW1059

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 TYR A 268
ARG A 269
MET A 272
THR A 273
 None
 1.32A 3abkN-1dlcA:
1.2
3abkW-1dlcA:
0.0		 3abkN-1dlcA:
20.97
3abkW-1dlcA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)

(Agrobacterium
tumefaciens) 		PF00561
(Abhydrolase_1) 		4 ILE A 255
TYR A 265
MET A 240
THR A 239
 None
 1.46A 3abkN-1ehyA:
0.0
3abkW-1ehyA:
undetectable		 3abkN-1ehyA:
20.81
3abkW-1ehyA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		4 ILE A 350
ARG A 308
MET A 311
THR A 312
 None
 1.26A 3abkN-1floA:
0.0
3abkW-1floA:
0.0		 3abkN-1floA:
21.78
3abkW-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g4u PROTEIN TYROSINE
PHOSPHATASE SPTP

(Salmonella
enterica) 		PF00102
(Y_phosphatase)
PF03545
(YopE) 		4 ILE S 415
ARG S 487
MET S 491
THR S 488
 None
 1.30A 3abkN-1g4uS:
0.2
3abkW-1g4uS:
0.0		 3abkN-1g4uS:
20.94
3abkW-1g4uS:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 ILE A  14
TYR A 169
MET A 180
THR A 188
 None
 1.21A 3abkN-1lf9A:
0.5
3abkW-1lf9A:
0.0		 3abkN-1lf9A:
20.80
3abkW-1lf9A:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 503
TYR A 439
MET A 532
THR A 531
 None
 1.28A 3abkN-1loxA:
0.9
3abkW-1loxA:
0.0		 3abkN-1loxA:
21.60
3abkW-1loxA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A1442
ARG A 511
MET A1424
THR A1425
 None
 1.19A 3abkN-1ofeA:
0.0
3abkW-1ofeA:
0.0		 3abkN-1ofeA:
15.55
3abkW-1ofeA:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofm CHONDROITINASE B

(Pedobacter
heparinus) 		PF14592
(Chondroitinas_B) 		4 ILE A 304
TYR A 283
MET A 268
THR A 267
 None
 1.03A 3abkN-1ofmA:
undetectable
3abkW-1ofmA:
0.0		 3abkN-1ofmA:
20.00
3abkW-1ofmA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		4 ILE A 298
TYR A 256
MET A 384
THR A 385
 None
 1.42A 3abkN-1s4fA:
0.0
3abkW-1s4fA:
0.0		 3abkN-1s4fA:
20.67
3abkW-1s4fA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgw PUTATIVE ABC
TRANSPORTER

(Pyrococcus
furiosus) 		PF00005
(ABC_tran) 		4 ILE A  47
ARG A   6
MET A  22
THR A  23
 None
 1.11A 3abkN-1sgwA:
undetectable
3abkW-1sgwA:
undetectable		 3abkN-1sgwA:
17.74
3abkW-1sgwA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 ILE E 109
ARG E 114
MET E 235
THR E 234
 None
 1.29A 3abkN-1skyE:
1.0
3abkW-1skyE:
undetectable		 3abkN-1skyE:
23.01
3abkW-1skyE:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v43 SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		4 ILE A 361
ARG A 310
MET A 294
THR A 295
 None
 1.41A 3abkN-1v43A:
undetectable
3abkW-1v43A:
undetectable		 3abkN-1v43A:
21.39
3abkW-1v43A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a24 ENDOTHELIAL PAS
DOMAIN PROTEIN 1

(Homo sapiens) 		PF08447
(PAS_3) 		4 ILE A 101
TYR A  45
MET A  53
THR A  54
 None
 1.13A 3abkN-2a24A:
undetectable
3abkW-2a24A:
undetectable		 3abkN-2a24A:
10.46
3abkW-2a24A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		4 ILE A 220
ARG A 297
MET A 314
THR A 315
 None
 1.27A 3abkN-2bmfA:
undetectable
3abkW-2bmfA:
undetectable		 3abkN-2bmfA:
21.62
3abkW-2bmfA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c21 TRYPANOTHIONE-DEPEND
ENT GLYOXALASE I

(Leishmania
major) 		PF00903
(Glyoxalase) 		4 ILE A  78
TYR A  49
MET A  29
THR A  24
 None
 1.48A 3abkN-2c21A:
undetectable
3abkW-2c21A:
undetectable		 3abkN-2c21A:
13.40
3abkW-2c21A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 TYR B 618
ARG B 619
MET B 622
THR B 623
 None
 1.00A 3abkN-2c6wB:
undetectable
3abkW-2c6wB:
undetectable		 3abkN-2c6wB:
21.23
3abkW-2c6wB:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ILE A 204
ARG A 296
MET A 299
THR A 300
 None
 1.27A 3abkN-2c9kA:
1.3
3abkW-2c9kA:
undetectable		 3abkN-2c9kA:
21.01
3abkW-2c9kA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edm 22KDA STRUCTURAL
PROTEIN VP22

(White spot
syndrome virus) 		PF12175
(WSS_VP) 		4 ILE A  96
ARG A  64
MET A 185
THR A 184
 None
 1.35A 3abkN-2edmA:
undetectable
3abkW-2edmA:
undetectable		 3abkN-2edmA:
15.27
3abkW-2edmA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jls SERINE PROTEASE
SUBUNIT NS3

(Dengue virus) 		PF07652
(Flavi_DEAD) 		4 ILE A 220
ARG A 297
MET A 314
THR A 315
 None
 1.10A 3abkN-2jlsA:
undetectable
3abkW-2jlsA:
undetectable		 3abkN-2jlsA:
21.54
3abkW-2jlsA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2le1 UNCHARACTERIZED
PROTEIN

(Thermobifida
fusca) 		PF10604
(Polyketide_cyc2) 		4 ILE A 125
TYR A  77
ARG A  90
MET A  79
 None
 1.30A 3abkN-2le1A:
undetectable
3abkW-2le1A:
undetectable		 3abkN-2le1A:
12.50
3abkW-2le1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A 100
ARG A  55
MET A  72
THR A  73
 None
 1.34A 3abkN-2rgwA:
undetectable
3abkW-2rgwA:
undetectable		 3abkN-2rgwA:
19.69
3abkW-2rgwA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0o FCH DOMAIN ONLY
PROTEIN 2

(Homo sapiens) 		PF00611
(FCH) 		4 ILE A 231
TYR A  49
MET A  53
THR A  54
 None
 1.30A 3abkN-2v0oA:
2.9
3abkW-2v0oA:
undetectable		 3abkN-2v0oA:
19.75
3abkW-2v0oA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 ILE A  36
ARG A 113
MET A 130
THR A 131
 None
 1.21A 3abkN-2v6jA:
undetectable
3abkW-2v6jA:
undetectable		 3abkN-2v6jA:
20.93
3abkW-2v6jA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 ILE A1405
ARG A 515
MET A1387
THR A1388
 None
 1.10A 3abkN-2vdcA:
undetectable
3abkW-2vdcA:
undetectable		 3abkN-2vdcA:
16.62
3abkW-2vdcA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		4 ILE A 220
ARG A 297
MET A 314
THR A 315
 None
 1.09A 3abkN-2whxA:
undetectable
3abkW-2whxA:
undetectable		 3abkN-2whxA:
21.69
3abkW-2whxA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ILE A 183
ARG A 231
MET A 234
THR A 213
 None
 0.98A 3abkN-2xe4A:
undetectable
3abkW-2xe4A:
undetectable		 3abkN-2xe4A:
19.95
3abkW-2xe4A:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ILE A 206
ARG A 231
MET A 234
THR A 213
 None
 1.19A 3abkN-2xe4A:
undetectable
3abkW-2xe4A:
undetectable		 3abkN-2xe4A:
19.95
3abkW-2xe4A:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		4 TYR J  32
ARG J  33
MET J  36
THR J  37
 None
 0.31A 3abkN-2y69J:
undetectable
3abkW-2y69J:
7.8		 3abkN-2y69J:
10.31
3abkW-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		4 ILE A 341
TYR A 361
ARG A 262
MET A 259
 None
 1.27A 3abkN-3b05A:
undetectable
3abkW-3b05A:
undetectable		 3abkN-3b05A:
22.18
3abkW-3b05A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzw PUTATIVE LIPASE

(Bacteroides
thetaiotaomicron) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 170
ARG A 165
MET A 157
THR A 158
 None
 1.47A 3abkN-3bzwA:
undetectable
3abkW-3bzwA:
undetectable		 3abkN-3bzwA:
18.49
3abkW-3bzwA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3col PUTATIVE
TRANSCRIPTION
REGULATOR

(Lactobacillus
plantarum) 		PF00440
(TetR_N) 		4 ILE A 182
TYR A 172
ARG A 171
THR A 165
 None
 1.23A 3abkN-3colA:
2.1
3abkW-3colA:
undetectable		 3abkN-3colA:
18.07
3abkW-3colA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		4 ILE A 502
TYR A 438
MET A 531
THR A 530
 None
 1.21A 3abkN-3d3lA:
undetectable
3abkW-3d3lA:
undetectable		 3abkN-3d3lA:
22.99
3abkW-3d3lA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP1

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 1 157
ARG 1 258
MET 1  90
THR 1  91
 None
 1.25A 3abkN-3epc1:
undetectable
3abkW-3epc1:
undetectable		 3abkN-3epc1:
20.11
3abkW-3epc1:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ILE A1107
ARG A1351
MET A1381
THR A1382
 None
 1.35A 3abkN-3h0gA:
undetectable
3abkW-3h0gA:
undetectable		 3abkN-3h0gA:
13.51
3abkW-3h0gA:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7o GROUP 3 ALLERGEN
SMIPP-S YV6023A04

(Sarcoptes
scabiei) 		PF00089
(Trypsin) 		4 TYR A  82
ARG A  83
MET A  87
THR A  86
 None
 1.16A 3abkN-3h7oA:
undetectable
3abkW-3h7oA:
undetectable		 3abkN-3h7oA:
16.77
3abkW-3h7oA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ILE A1089
TYR A1078
ARG A1085
THR A 500
 None
None
COA  A2001 (-3.5A)
None
 1.47A 3abkN-3ho8A:
undetectable
3abkW-3ho8A:
undetectable		 3abkN-3ho8A:
17.96
3abkW-3ho8A:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		4 ILE A 882
ARG A 808
MET A 811
THR A 812
 None
SO4  A   3 (-4.1A)
None
None
 1.29A 3abkN-3k7dA:
undetectable
3abkW-3k7dA:
undetectable		 3abkN-3k7dA:
21.52
3abkW-3k7dA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		4 ILE A 219
TYR A 201
ARG A 204
THR A  94
 None
 1.33A 3abkN-3lggA:
undetectable
3abkW-3lggA:
undetectable		 3abkN-3lggA:
21.16
3abkW-3lggA:
6.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 ILE X 353
ARG X 319
MET X 321
THR X 322
 None
 1.27A 3abkN-3lxuX:
undetectable
3abkW-3lxuX:
undetectable		 3abkN-3lxuX:
16.39
3abkW-3lxuX:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr0 SENSORY BOX
HISTIDINE
KINASE/RESPONSE
REGULATOR

(Burkholderia
thailandensis) 		PF08447
(PAS_3) 		4 ILE A  50
ARG A  88
MET A  39
THR A  87
 None
None
PG5  A 143 ( 4.5A)
None
 1.23A 3abkN-3mr0A:
undetectable
3abkW-3mr0A:
undetectable		 3abkN-3mr0A:
13.07
3abkW-3mr0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 ILE A  85
ARG A  32
MET A 132
THR A 133
 None
 1.48A 3abkN-3mzvA:
1.7
3abkW-3mzvA:
undetectable		 3abkN-3mzvA:
20.23
3abkW-3mzvA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncv DNA MISMATCH REPAIR
PROTEIN MUTL

(Neisseria
gonorrhoeae) 		PF08676
(MutL_C) 		4 ILE A 608
ARG A 498
MET A 626
THR A 629
 None
 1.41A 3abkN-3ncvA:
undetectable
3abkW-3ncvA:
undetectable		 3abkN-3ncvA:
17.43
3abkW-3ncvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		4 ILE A 382
ARG A 415
MET A 396
THR A 397
 None
 1.30A 3abkN-3ohnA:
undetectable
3abkW-3ohnA:
undetectable		 3abkN-3ohnA:
21.45
3abkW-3ohnA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN

(Chloroflexus
aurantiacus) 		PF13560
(HTH_31) 		4 ILE A 281
TYR A 148
ARG A 152
THR A 140
 None
 1.36A 3abkN-3pxpA:
undetectable
3abkW-3pxpA:
undetectable		 3abkN-3pxpA:
19.44
3abkW-3pxpA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqz PUTATIVE
UNCHARACTERIZED
PROTEIN YJIK

(Escherichia
coli) 		PF06977
(SdiA-regulated) 		4 ILE A  97
ARG A 130
MET A 122
THR A 108
 None
 1.33A 3abkN-3qqzA:
undetectable
3abkW-3qqzA:
undetectable		 3abkN-3qqzA:
18.34
3abkW-3qqzA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 ILE A 360
TYR A 337
ARG A 299
THR A 301
 None
 1.47A 3abkN-3s6kA:
undetectable
3abkW-3s6kA:
undetectable		 3abkN-3s6kA:
22.74
3abkW-3s6kA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 ILE A 301
ARG A 328
MET A 327
THR A 326
 None
 1.37A 3abkN-3t05A:
undetectable
3abkW-3t05A:
undetectable		 3abkN-3t05A:
19.44
3abkW-3t05A:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A  99
ARG A 302
MET A  63
THR A  61
 None
 1.38A 3abkN-3txxA:
undetectable
3abkW-3txxA:
undetectable		 3abkN-3txxA:
20.80
3abkW-3txxA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ILE A 122
ARG A 302
MET A  63
THR A  61
 None
 1.25A 3abkN-3txxA:
undetectable
3abkW-3txxA:
undetectable		 3abkN-3txxA:
20.80
3abkW-3txxA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0k RCAMP

(Entacmaea
quadricolor) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 ILE A 394
ARG A  40
MET A 439
THR A 440
 None
 1.40A 3abkN-3u0kA:
undetectable
3abkW-3u0kA:
undetectable		 3abkN-3u0kA:
20.60
3abkW-3u0kA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ILE A2827
ARG A2877
MET A2682
THR A2681
 ADP  A9003 (-3.8A)
None
ADP  A9003 (-3.4A)
ADP  A9003 (-3.5A)
 1.48A 3abkN-3vkgA:
undetectable
3abkW-3vkgA:
undetectable		 3abkN-3vkgA:
9.59
3abkW-3vkgA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vts CYTOTOXIN 1

(Hemachatus
haemachatus) 		PF00087
(Toxin_TOLIP) 		4 TYR A  23
ARG A  37
MET A  25
THR A  26
 None
 1.27A 3abkN-3vtsA:
undetectable
3abkW-3vtsA:
undetectable		 3abkN-3vtsA:
6.94
3abkW-3vtsA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		4 ILE A  80
TYR A  61
ARG A  93
MET A  65
 None
 1.01A 3abkN-3zs7A:
1.2
3abkW-3zs7A:
undetectable		 3abkN-3zs7A:
18.92
3abkW-3zs7A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3l BMAL1B

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		4 ILE B 408
TYR B 340
ARG B 356
THR B 439
 None
 1.48A 3abkN-4f3lB:
undetectable
3abkW-4f3lB:
undetectable		 3abkN-4f3lB:
20.64
3abkW-4f3lB:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		4 ILE A 216
ARG A 227
MET A 229
THR A 230
 None
 1.27A 3abkN-4fx5A:
undetectable
3abkW-4fx5A:
undetectable		 3abkN-4fx5A:
21.46
3abkW-4fx5A:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		4 ILE A 171
ARG A 183
MET A 188
THR A 189
 None
 1.34A 3abkN-4go4A:
undetectable
3abkW-4go4A:
undetectable		 3abkN-4go4A:
22.22
3abkW-4go4A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 ILE A 314
TYR A 358
ARG A 361
THR A 324
 None
 1.48A 3abkN-4i5jA:
undetectable
3abkW-4i5jA:
undetectable		 3abkN-4i5jA:
19.31
3abkW-4i5jA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 ILE A 537
ARG A 591
MET A 529
THR A 530
 None
NAG  A2010 (-2.9A)
None
NAG  A2009 (-3.5A)
 1.20A 3abkN-4lxrA:
undetectable
3abkW-4lxrA:
undetectable		 3abkN-4lxrA:
20.28
3abkW-4lxrA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE

(Thermococcus
onnurineus) 		PF02006
(PPS_PS) 		4 ILE A 178
TYR A 204
MET A 207
THR A 208
 None
 1.35A 3abkN-4mb2A:
undetectable
3abkW-4mb2A:
undetectable		 3abkN-4mb2A:
19.23
3abkW-4mb2A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		4 ILE A  59
TYR A  12
ARG A  22
THR A  20
 None
 1.37A 3abkN-4o6mA:
undetectable
3abkW-4o6mA:
undetectable		 3abkN-4o6mA:
20.87
3abkW-4o6mA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r37 PUTATIVE
ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Bacteroides
fragilis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 ILE A 174
TYR A 216
ARG A 255
THR A 222
 None
 1.43A 3abkN-4r37A:
undetectable
3abkW-4r37A:
undetectable		 3abkN-4r37A:
19.38
3abkW-4r37A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes) 		PF04198
(Sugar-bind) 		4 ILE A 141
TYR A 223
MET A 218
THR A 217
 None
 1.49A 3abkN-4r9nA:
undetectable
3abkW-4r9nA:
undetectable		 3abkN-4r9nA:
17.97
3abkW-4r9nA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk9 CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN MSME

(Bacillus
licheniformis) 		PF01547
(SBP_bac_1) 		4 ILE A 338
ARG A 307
MET A  40
THR A  39
 None
GLA  A 503 (-2.8A)
None
GLA  A 502 ( 3.8A)
 0.82A 3abkN-4rk9A:
undetectable
3abkW-4rk9A:
undetectable		 3abkN-4rk9A:
21.64
3abkW-4rk9A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A  56
TYR A 256
MET A 257
THR A 258
 None
 1.43A 3abkN-4xg1A:
undetectable
3abkW-4xg1A:
undetectable		 3abkN-4xg1A:
22.83
3abkW-4xg1A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN

(Candidatus
Nitrososphaera
gargensis) 		PF00561
(Abhydrolase_1) 		4 ILE A  32
ARG A  59
MET A  74
THR A  73
 ACT  A 484 (-3.8A)
None
None
None
 1.03A 3abkN-5a62A:
undetectable
3abkW-5a62A:
undetectable		 3abkN-5a62A:
19.92
3abkW-5a62A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e05 NUCLEOCAPSID PROTEIN

(Sin Nombre
orthohantavirus) 		PF00846
(Hanta_nucleocap) 		4 ILE A 373
TYR A 364
ARG A 367
THR A 200
 None
 1.33A 3abkN-5e05A:
undetectable
3abkW-5e05A:
undetectable		 3abkN-5e05A:
20.72
3abkW-5e05A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ILE A 203
ARG A 322
MET A 394
THR A 392
 None
 1.24A 3abkN-5e4rA:
undetectable
3abkW-5e4rA:
undetectable		 3abkN-5e4rA:
23.43
3abkW-5e4rA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ILE A 350
ARG A 469
MET A 247
THR A 245
 None
 1.13A 3abkN-5e4rA:
undetectable
3abkW-5e4rA:
undetectable		 3abkN-5e4rA:
23.43
3abkW-5e4rA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		4 ILE A4801
TYR A4762
MET A4765
THR A4767
 None
 0.99A 3abkN-5f59A:
undetectable
3abkW-5f59A:
undetectable		 3abkN-5f59A:
13.20
3abkW-5f59A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk2 KETOSYNTHASE STLD

(Photorhabdus
laumondii) 		PF08541
(ACP_syn_III_C) 		4 ILE A  48
TYR A  53
MET A  24
THR A  23
 None
 0.96A 3abkN-5gk2A:
undetectable
3abkW-5gk2A:
undetectable		 3abkN-5gk2A:
19.85
3abkW-5gk2A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		4 ILE A 170
ARG A 235
MET A 237
THR A 238
 None
 1.15A 3abkN-5h6sA:
undetectable
3abkW-5h6sA:
undetectable		 3abkN-5h6sA:
20.08
3abkW-5h6sA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		4 ILE A 194
TYR A 177
MET A 203
THR A 204
 None
 1.41A 3abkN-5hs1A:
undetectable
3abkW-5hs1A:
undetectable		 3abkN-5hs1A:
22.64
3abkW-5hs1A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 ILE A 401
ARG A 375
MET A 373
THR A 372
 None
SO4  A 702 (-4.1A)
None
None
 1.39A 3abkN-5ic7A:
undetectable
3abkW-5ic7A:
undetectable		 3abkN-5ic7A:
21.09
3abkW-5ic7A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktz VP1

(Enterovirus C) 		PF00073
(Rhv) 		4 ILE 1 157
ARG 1 258
MET 1  90
THR 1  91
 None
 1.13A 3abkN-5ktz1:
undetectable
3abkW-5ktz1:
undetectable		 3abkN-5ktz1:
15.79
3abkW-5ktz1:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 ILE B 411
TYR B 442
MET B 407
THR B 445
 PEG  B 805 (-4.4A)
None
None
None
 1.32A 3abkN-5ldrB:
undetectable
3abkW-5ldrB:
undetectable		 3abkN-5ldrB:
20.51
3abkW-5ldrB:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		4 ILE A1045
TYR A1773
MET A1777
THR A1775
 None
 1.46A 3abkN-5lkiA:
2.6
3abkW-5lkiA:
undetectable		 3abkN-5lkiA:
11.55
3abkW-5lkiA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwl INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Mus musculus) 		PF06090
(Ins_P5_2-kin) 		4 TYR A 392
ARG A 393
MET A 396
THR A 397
 None
 0.95A 3abkN-5mwlA:
undetectable
3abkW-5mwlA:
undetectable		 3abkN-5mwlA:
19.60
3abkW-5mwlA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5a PEREGRIN

(Homo sapiens) 		no annotation 4 TYR A 687
ARG A 686
MET A 678
THR A 677
 None
 1.06A 3abkN-5o5aA:
undetectable
3abkW-5o5aA:
undetectable		 3abkN-5o5aA:
undetectable
3abkW-5o5aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzn KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY B MEMBER
1B ALLELE B
GLYCOPROTEIN FAMILY
PROTEIN M12

(Mus musculus;
Murid
betaherpesvirus
1) 		PF00059
(Lectin_C)
PF12216
(m04gp34like) 		4 TYR A 158
ARG F  49
MET A 163
THR A 161
 None
 1.37A 3abkN-5tznA:
undetectable
3abkW-5tznA:
undetectable		 3abkN-5tznA:
13.13
3abkW-5tznA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxz GROWTH
ARREST-SPECIFIC
PROTEIN 6
TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens;
Homo sapiens) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2)
PF13927
(Ig_3) 		4 ILE C  90
ARG A 467
MET A 468
THR A 466
 None
 1.50A 3abkN-5vxzC:
undetectable
3abkW-5vxzC:
undetectable		 3abkN-5vxzC:
10.33
3abkW-5vxzC:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		4 ILE A  86
TYR A  77
MET A 295
THR A 294
 None
 0.90A 3abkN-5xe0A:
undetectable
3abkW-5xe0A:
undetectable		 3abkN-5xe0A:
20.98
3abkW-5xe0A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		4 ILE A 126
TYR A  98
ARG A 129
MET A  97
 None
 1.31A 3abkN-5xe0A:
undetectable
3abkW-5xe0A:
undetectable		 3abkN-5xe0A:
20.98
3abkW-5xe0A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xey PHLORETIN HYDROLASE

(Mycobacteroides
abscessus) 		no annotation 4 ILE A 166
TYR A 232
MET A 215
THR A 214
 None
 1.45A 3abkN-5xeyA:
undetectable
3abkW-5xeyA:
undetectable		 3abkN-5xeyA:
undetectable
3abkW-5xeyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN

(Zika virus) 		no annotation 4 ILE A 221
ARG A 298
MET A 315
THR A 316
 None
 1.09A 3abkN-5y6nA:
undetectable
3abkW-5y6nA:
undetectable		 3abkN-5y6nA:
undetectable
3abkW-5y6nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 4 ILE C  45
ARG C  66
MET C  68
THR C  69
 None
 1.08A 3abkN-6cajC:
undetectable
3abkW-6cajC:
undetectable		 3abkN-6cajC:
undetectable
3abkW-6cajC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT

(Pyrococcus
furiosus) 		no annotation 4 ILE E  59
TYR E  67
ARG E  68
THR E  42
 None
 1.48A 3abkN-6cfwE:
undetectable
3abkW-6cfwE:
undetectable		 3abkN-6cfwE:
undetectable
3abkW-6cfwE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epc PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
12

(Rattus
norvegicus) 		no annotation 4 ILE P 363
ARG P 377
MET P 375
THR P 374
 None
 1.19A 3abkN-6epcP:
0.7
3abkW-6epcP:
undetectable		 3abkN-6epcP:
undetectable
3abkW-6epcP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 4 ILE A2391
TYR A1895
MET A1910
THR A1909
 None
 1.45A 3abkN-6fayA:
undetectable
3abkW-6fayA:
undetectable		 3abkN-6fayA:
undetectable
3abkW-6fayA:
undetectable