SIMILAR PATTERNS OF AMINO ACIDS FOR 3ABK_P_CHDP1271

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		4 LEU A2086
PHE A2017
LEU A2013
PHE A2009
 None
 0.86A 3abkP-1914A:
0.7
3abkW-1914A:
undetectable		 3abkP-1914A:
19.40
3abkW-1914A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agx GLUTAMINASE-ASPARAGI
NASE

(Acinetobacter
glutaminasificans) 		PF00710
(Asparaginase) 		4 LEU A 313
PHE A 205
LEU A 104
PHE A 100
 None
 0.99A 3abkP-1agxA:
undetectable
3abkW-1agxA:
undetectable		 3abkP-1agxA:
21.25
3abkW-1agxA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  31
LEU A  41
PHE A  19
LEU A  24
 None
 0.93A 3abkP-1bucA:
3.8
3abkW-1bucA:
0.0		 3abkP-1bucA:
17.69
3abkW-1bucA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 164
PHE A 175
LEU A 179
PHE A 183
 None
 0.74A 3abkP-1dj3A:
undetectable
3abkW-1dj3A:
0.0		 3abkP-1dj3A:
19.00
3abkW-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 200
PHE A 183
LEU A 179
PHE A 175
 None
 0.73A 3abkP-1dj3A:
undetectable
3abkW-1dj3A:
0.0		 3abkP-1dj3A:
19.00
3abkW-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 LEU A 342
PHE A 347
PHE A 108
LEU A 104
 None
 1.01A 3abkP-1dq3A:
undetectable
3abkW-1dq3A:
0.0		 3abkP-1dq3A:
17.80
3abkW-1dq3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
 None
 0.83A 3abkP-1jkwA:
0.7
3abkW-1jkwA:
0.0		 3abkP-1jkwA:
20.52
3abkW-1jkwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 1.01A 3abkP-1js6A:
undetectable
3abkW-1js6A:
0.0		 3abkP-1js6A:
19.84
3abkW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.86A 3abkP-1kl7A:
undetectable
3abkW-1kl7A:
0.0		 3abkP-1kl7A:
21.24
3abkW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
PHE B 592
LEU B 596
PHE B 598
 None
 1.00A 3abkP-1ovlB:
0.8
3abkW-1ovlB:
0.0		 3abkP-1ovlB:
19.94
3abkW-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		4 LEU A  45
PHE A  46
LEU A  80
PHE A 173
 GOL  A1616 ( 4.9A)
None
None
None
 0.90A 3abkP-1pjaA:
undetectable
3abkW-1pjaA:
undetectable		 3abkP-1pjaA:
22.12
3abkW-1pjaA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.94A 3abkP-1u8vA:
3.8
3abkW-1u8vA:
undetectable		 3abkP-1u8vA:
19.70
3abkW-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vku ACYL CARRIER PROTEIN

(Thermotoga
maritima) 		PF00550
(PP-binding) 		4 LEU A  70
PHE A  48
LEU A  44
PHE A  36
 None
 0.97A 3abkP-1vkuA:
undetectable
3abkW-1vkuA:
undetectable		 3abkP-1vkuA:
13.64
3abkW-1vkuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli) 		PF13531
(SBP_bac_11) 		4 LEU A  80
PHE A 230
PHE A 225
LEU A 216
 None
 1.01A 3abkP-1wodA:
undetectable
3abkW-1wodA:
undetectable		 3abkP-1wodA:
19.08
3abkW-1wodA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 LEU A   5
PHE A 235
LEU A 231
PHE A 227
 None
 0.93A 3abkP-1xw8A:
undetectable
3abkW-1xw8A:
undetectable		 3abkP-1xw8A:
18.97
3abkW-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia) 		PF00561
(Abhydrolase_1) 		4 LEU X 167
PHE X 119
LEU X  17
PHE X  52
 2HS  X 600 ( 4.5A)
None
2HS  X 600 (-4.1A)
None
 0.98A 3abkP-1ys2X:
undetectable
3abkW-1ys2X:
undetectable		 3abkP-1ys2X:
22.32
3abkW-1ys2X:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 LEU A 184
PHE A 158
LEU A 176
PHE A 172
 None
 0.90A 3abkP-1yw6A:
undetectable
3abkW-1yw6A:
undetectable		 3abkP-1yw6A:
20.54
3abkW-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		4 LEU A 236
PHE A 240
PHE A 168
LEU A 172
 None
 0.72A 3abkP-1z7mA:
undetectable
3abkW-1z7mA:
undetectable		 3abkP-1z7mA:
20.44
3abkW-1z7mA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dog PROBABLE 16S
RRNA-PROCESSING
PROTEIN RIMM

(Thermus
thermophilus) 		PF01782
(RimM) 		4 LEU A  19
PHE A  21
PHE A   9
LEU A  69
 None
 0.97A 3abkP-2dogA:
undetectable
3abkW-2dogA:
undetectable		 3abkP-2dogA:
18.33
3abkW-2dogA:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 LEU A 428
PHE A 431
PHE A 391
LEU A 395
 None
 0.95A 3abkP-2dpyA:
undetectable
3abkW-2dpyA:
undetectable		 3abkP-2dpyA:
20.50
3abkW-2dpyA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 LEU A 350
PHE A 349
PHE A 346
LEU A  86
 None
 0.94A 3abkP-2gwcA:
undetectable
3abkW-2gwcA:
undetectable		 3abkP-2gwcA:
19.51
3abkW-2gwcA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haj DNA PRIMASE

(Escherichia
coli) 		PF08278
(DnaG_DnaB_bind) 		4 LEU A 454
PHE A 535
LEU A 539
PHE A 543
 None
 0.88A 3abkP-2hajA:
undetectable
3abkW-2hajA:
undetectable		 3abkP-2hajA:
19.01
3abkW-2hajA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis) 		PF13419
(HAD_2) 		5 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
 None
 1.43A 3abkP-2i6xA:
undetectable
3abkW-2i6xA:
undetectable		 3abkP-2i6xA:
20.30
3abkW-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 131
PHE A 135
PHE A  74
LEU A  70
 None
 0.92A 3abkP-2ibdA:
undetectable
3abkW-2ibdA:
undetectable		 3abkP-2ibdA:
24.73
3abkW-2ibdA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 1.00A 3abkP-2iopA:
undetectable
3abkW-2iopA:
undetectable		 3abkP-2iopA:
16.83
3abkW-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.88A 3abkP-2nt8A:
2.8
3abkW-2nt8A:
undetectable		 3abkP-2nt8A:
21.30
3abkW-2nt8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
 None
 0.60A 3abkP-2optA:
3.1
3abkW-2optA:
undetectable		 3abkP-2optA:
23.19
3abkW-2optA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A
TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		4 PHE A  99
PHE B   9
LEU B  14
PHE B  18
 None
 0.94A 3abkP-2p1nA:
undetectable
3abkW-2p1nA:
undetectable		 3abkP-2p1nA:
18.58
3abkW-2p1nA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pe4 HYALURONIDASE-1

(Homo sapiens) 		PF01630
(Glyco_hydro_56) 		4 ARG A 194
LEU A 193
PHE A 110
LEU A 114
 None
 1.00A 3abkP-2pe4A:
undetectable
3abkW-2pe4A:
undetectable		 3abkP-2pe4A:
21.24
3abkW-2pe4A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		5 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.42A 3abkP-2q2rA:
undetectable
3abkW-2q2rA:
undetectable		 3abkP-2q2rA:
21.78
3abkW-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		4 LEU A 113
PHE A  93
PHE A 123
LEU A  70
 None
 0.97A 3abkP-2riuA:
undetectable
3abkW-2riuA:
undetectable		 3abkP-2riuA:
21.66
3abkW-2riuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wch GENERAL
ODORANT-BINDING
PROTEIN 1

(Bombyx mori) 		PF01395
(PBP_GOBP) 		5 ARG A  20
LEU A  16
PHE A  12
PHE A  33
LEU A  30
 None
None
B7M  A1145 (-3.7A)
None
None
 1.42A 3abkP-2wchA:
undetectable
3abkW-2wchA:
undetectable		 3abkP-2wchA:
17.25
3abkW-2wchA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.75A 3abkP-2yd0A:
undetectable
3abkW-2yd0A:
undetectable		 3abkP-2yd0A:
14.57
3abkW-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 LEU C  35
PHE C  60
PHE C  33
LEU C  87
 None
 1.02A 3abkP-2ynmC:
undetectable
3abkW-2ynmC:
undetectable		 3abkP-2ynmC:
21.92
3abkW-2ynmC:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeu LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		4 LEU A  44
PHE A  69
PHE A  42
LEU A  96
 None
 1.01A 3abkP-3aeuA:
undetectable
3abkW-3aeuA:
undetectable		 3abkP-3aeuA:
22.02
3abkW-3aeuA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b86 GENERAL
ODORANT-BINDING
PROTEIN LUSH

(Drosophila
melanogaster) 		PF01395
(PBP_GOBP) 		4 LEU A  44
PHE A  21
LEU A  31
PHE A  36
 None
 0.98A 3abkP-3b86A:
undetectable
3abkW-3b86A:
undetectable		 3abkP-3b86A:
17.60
3abkW-3b86A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 4 LEU A 123
PHE A 121
PHE A  45
LEU A  18
 None
 0.92A 3abkP-3ba3A:
undetectable
3abkW-3ba3A:
undetectable		 3abkP-3ba3A:
21.19
3abkW-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU C  73
PHE C  75
PHE C   7
LEU C 176
 None
 1.02A 3abkP-3degC:
undetectable
3abkW-3degC:
undetectable		 3abkP-3degC:
17.43
3abkW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3exn PROBABLE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00583
(Acetyltransf_1) 		4 LEU A  63
PHE A  62
LEU A  22
PHE A  26
 None
 0.89A 3abkP-3exnA:
undetectable
3abkW-3exnA:
undetectable		 3abkP-3exnA:
23.02
3abkW-3exnA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
LEU A 192
PHE A 196
PHE A 153
 None
 0.84A 3abkP-3g1zA:
undetectable
3abkW-3g1zA:
undetectable		 3abkP-3g1zA:
20.94
3abkW-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.88A 3abkP-3gajA:
2.7
3abkW-3gajA:
undetectable		 3abkP-3gajA:
21.16
3abkW-3gajA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 LEU A  80
PHE A 230
PHE A 225
LEU A 216
PHE A 212
 None
 1.25A 3abkP-3gzgA:
undetectable
3abkW-3gzgA:
undetectable		 3abkP-3gzgA:
24.09
3abkW-3gzgA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 1.02A 3abkP-3iv0A:
1.8
3abkW-3iv0A:
undetectable		 3abkP-3iv0A:
20.57
3abkW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 LEU A 530
PHE A 569
LEU A 566
PHE A 526
 None
 1.00A 3abkP-3j9dA:
undetectable
3abkW-3j9dA:
undetectable		 3abkP-3j9dA:
13.31
3abkW-3j9dA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 354
LEU A 357
PHE A 361
 None
 0.96A 3abkP-3k40A:
undetectable
3abkW-3k40A:
undetectable		 3abkP-3k40A:
19.79
3abkW-3k40A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		4 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 1.01A 3abkP-3k6xA:
undetectable
3abkW-3k6xA:
undetectable		 3abkP-3k6xA:
20.87
3abkW-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.88A 3abkP-3lcrA:
undetectable
3abkW-3lcrA:
undetectable		 3abkP-3lcrA:
20.45
3abkW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE

(Coccidioides
immitis) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		4 LEU A   8
PHE A   6
PHE A  24
LEU A  20
 None
 0.95A 3abkP-3lg6A:
2.7
3abkW-3lg6A:
undetectable		 3abkP-3lg6A:
20.29
3abkW-3lg6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 LEU A 204
PHE A 208
LEU A 187
PHE A 195
 None
None
None
EDO  A 231 (-3.8A)
 0.97A 3abkP-3mvuA:
undetectable
3abkW-3mvuA:
undetectable		 3abkP-3mvuA:
20.30
3abkW-3mvuA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PHE A 327
PHE A 299
LEU A 296
PHE A 294
 None
 1.01A 3abkP-3ogrA:
undetectable
3abkW-3ogrA:
undetectable		 3abkP-3ogrA:
14.48
3abkW-3ogrA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqq PUTATIVE LIPOPROTEIN

(Bacteroides
ovatus) 		PF16129
(DUF4841)
PF16130
(DUF4842) 		4 LEU A 214
PHE A 152
PHE A 173
LEU A 201
 None
 0.93A 3abkP-3oqqA:
undetectable
3abkW-3oqqA:
undetectable		 3abkP-3oqqA:
20.13
3abkW-3oqqA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pja TRANSLIN

(Homo sapiens) 		PF01997
(Translin) 		4 ARG A 166
LEU A 154
PHE A 104
LEU A 108
 None
 0.96A 3abkP-3pjaA:
3.8
3abkW-3pjaA:
undetectable		 3abkP-3pjaA:
20.88
3abkW-3pjaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8i ODORANT BINDING
PROTEIN

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		4 LEU A  44
PHE A  21
LEU A  31
PHE A  36
 None
 1.00A 3abkP-3q8iA:
undetectable
3abkW-3q8iA:
undetectable		 3abkP-3q8iA:
17.72
3abkW-3q8iA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 ARG A 131
LEU A 191
PHE A 246
LEU A 241
 None
 0.99A 3abkP-3rd5A:
undetectable
3abkW-3rd5A:
undetectable		 3abkP-3rd5A:
21.79
3abkW-3rd5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 4 LEU A 119
PHE A  95
LEU A  91
PHE A  87
 None
 0.99A 3abkP-3wvrA:
undetectable
3abkW-3wvrA:
undetectable		 3abkP-3wvrA:
19.19
3abkW-3wvrA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgb PUTATIVE SUGAR
KINASE MK0840

(Methanopyrus
kandleri) 		PF03702
(AnmK) 		4 LEU A 276
PHE A 237
LEU A 226
PHE A 222
 None
 0.93A 3abkP-4bgbA:
undetectable
3abkW-4bgbA:
undetectable		 3abkP-4bgbA:
19.53
3abkW-4bgbA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bt1 TRANSCRIPTIONAL
REGULATOR

(Escherichia
virus Mu) 		PF00158
(Sigma54_activat) 		4 LEU B 194
PHE B 204
LEU B 208
PHE B 227
 None
 1.00A 3abkP-4bt1B:
undetectable
3abkW-4bt1B:
undetectable		 3abkP-4bt1B:
18.22
3abkW-4bt1B:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.74A 3abkP-4c8qH:
undetectable
3abkW-4c8qH:
undetectable		 3abkP-4c8qH:
19.40
3abkW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 321
PHE A  23
PHE A  25
LEU A 376
 None
 0.96A 3abkP-4e5tA:
undetectable
3abkW-4e5tA:
undetectable		 3abkP-4e5tA:
21.58
3abkW-4e5tA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.86A 3abkP-4flxA:
undetectable
3abkW-4flxA:
undetectable		 3abkP-4flxA:
13.49
3abkW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hc5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphaerobacter
thermophilus) 		PF00903
(Glyoxalase) 		4 LEU A 127
PHE A 125
PHE A 117
LEU A  94
 None
 0.95A 3abkP-4hc5A:
undetectable
3abkW-4hc5A:
undetectable		 3abkP-4hc5A:
19.38
3abkW-4hc5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipa PUTATIVE CURVED
DNA-BINDING PROTEIN

(Chaetomium
thermophilum) 		PF00557
(Peptidase_M24) 		4 LEU A 147
PHE A 146
PHE A 362
LEU A 359
 None
 1.02A 3abkP-4ipaA:
undetectable
3abkW-4ipaA:
undetectable		 3abkP-4ipaA:
20.05
3abkW-4ipaA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 228
PHE A 230
LEU A 203
PHE A 199
 None
 1.01A 3abkP-4j0mA:
undetectable
3abkW-4j0mA:
undetectable		 3abkP-4j0mA:
16.01
3abkW-4j0mA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 PHE A 180
PHE A 177
LEU A 158
PHE A 160
 None
 1.01A 3abkP-4j72A:
undetectable
3abkW-4j72A:
undetectable		 3abkP-4j72A:
22.37
3abkW-4j72A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		no annotation 4 LEU C 121
PHE C 261
LEU C 252
PHE C 248
 None
 1.01A 3abkP-4kd5C:
undetectable
3abkW-4kd5C:
undetectable		 3abkP-4kd5C:
19.08
3abkW-4kd5C:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4u TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.99A 3abkP-4l4uA:
undetectable
3abkW-4l4uA:
undetectable		 3abkP-4l4uA:
18.32
3abkW-4l4uA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A  67
PHE A 104
LEU A  94
PHE A   4
 None
 0.97A 3abkP-4nreA:
undetectable
3abkW-4nreA:
undetectable		 3abkP-4nreA:
18.02
3abkW-4nreA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ARG A 296
LEU A 506
PHE A 508
LEU A 503
 None
 0.91A 3abkP-4pfwA:
undetectable
3abkW-4pfwA:
undetectable		 3abkP-4pfwA:
19.14
3abkW-4pfwA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 4 LEU B  75
PHE B  83
LEU B  87
PHE B  91
 None
 0.77A 3abkP-4r0mB:
undetectable
3abkW-4r0mB:
undetectable		 3abkP-4r0mB:
17.42
3abkW-4r0mB:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgp CSM6_III-A

(Streptococcus
mutans) 		PF09659
(Cas_Csm6) 		4 LEU A 221
PHE A 220
PHE A  98
LEU A  86
 None
 1.00A 3abkP-4rgpA:
undetectable
3abkW-4rgpA:
undetectable		 3abkP-4rgpA:
20.82
3abkW-4rgpA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ARG A 196
LEU A 163
PHE A 185
LEU A 189
 None
 0.76A 3abkP-4rncA:
undetectable
3abkW-4rncA:
undetectable		 3abkP-4rncA:
21.32
3abkW-4rncA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpx CELL DIVISION
CONTROL PROTEIN
31-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 ARG A  27
PHE A  50
PHE A  35
LEU A  34
 None
 0.99A 3abkP-4wpxA:
undetectable
3abkW-4wpxA:
undetectable		 3abkP-4wpxA:
21.84
3abkW-4wpxA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		4 LEU A 461
PHE A 464
PHE A 460
LEU A 387
 None
 0.96A 3abkP-4y0iA:
undetectable
3abkW-4y0iA:
undetectable		 3abkP-4y0iA:
19.27
3abkW-4y0iA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aox SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN

(Homo sapiens) 		PF02290
(SRP14) 		4 LEU B  86
PHE B  17
LEU B  13
PHE B   9
 None
 0.88A 3abkP-5aoxB:
undetectable
3abkW-5aoxB:
undetectable		 3abkP-5aoxB:
17.86
3abkW-5aoxB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		4 PHE A  93
PHE A  85
LEU A 130
PHE A 123
 None
 0.95A 3abkP-5b4sA:
undetectable
3abkW-5b4sA:
undetectable		 3abkP-5b4sA:
22.65
3abkW-5b4sA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 ARG A  80
LEU A  70
PHE A 111
PHE A  42
 None
 0.94A 3abkP-5ckmA:
undetectable
3abkW-5ckmA:
undetectable		 3abkP-5ckmA:
22.33
3abkW-5ckmA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6g DE NOVO DESIGNED
PROTEIN CA01

(synthetic
construct) 		no annotation 4 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.83A 3abkP-5e6gA:
3.6
3abkW-5e6gA:
undetectable		 3abkP-5e6gA:
19.51
3abkW-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A  47
PHE A  49
PHE A 207
LEU A 217
 None
 1.02A 3abkP-5eytA:
4.6
3abkW-5eytA:
undetectable		 3abkP-5eytA:
18.88
3abkW-5eytA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgr CELL SURFACE PROTEIN
SPAA

(Lactobacillus
rhamnosus) 		no annotation 4 LEU A 210
PHE A 245
LEU A 255
PHE A 258
 None
 1.01A 3abkP-5fgrA:
undetectable
3abkW-5fgrA:
undetectable		 3abkP-5fgrA:
16.15
3abkW-5fgrA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu6 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 3

(Homo sapiens) 		PF04153
(NOT2_3_5) 		4 LEU C 671
PHE C 673
LEU C 666
PHE C 662
 None
 0.93A 3abkP-5fu6C:
undetectable
3abkW-5fu6C:
undetectable		 3abkP-5fu6C:
18.59
3abkW-5fu6C:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		4 ARG A  36
LEU A  38
PHE A  14
LEU A  13
 None
 1.00A 3abkP-5gnmA:
undetectable
3abkW-5gnmA:
undetectable		 3abkP-5gnmA:
21.04
3abkW-5gnmA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdl CELL SURFACE PROTEIN
SPAA

(Lactobacillus
rhamnosus) 		no annotation 4 LEU A 210
PHE A 245
LEU A 255
PHE A 258
 None
 1.00A 3abkP-5hdlA:
undetectable
3abkW-5hdlA:
undetectable		 3abkP-5hdlA:
22.39
3abkW-5hdlA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 PHE A 174
PHE A 101
LEU A  97
PHE A  92
 None
 1.00A 3abkP-5huuA:
undetectable
3abkW-5huuA:
undetectable		 3abkP-5huuA:
19.58
3abkW-5huuA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 ARG A 293
LEU A 295
PHE A 173
LEU A 177
 None
 0.99A 3abkP-5i2hA:
undetectable
3abkW-5i2hA:
undetectable		 3abkP-5i2hA:
22.46
3abkW-5i2hA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		4 LEU A  87
PHE A 204
LEU A 208
PHE A 212
 None
 0.90A 3abkP-5ipxA:
undetectable
3abkW-5ipxA:
undetectable		 3abkP-5ipxA:
20.47
3abkW-5ipxA:
11.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		5 ARG C 156
LEU C 160
PHE C 164
PHE C 219
LEU C 223
 CHD  C 307 (-4.0A)
CHD  C 307 ( 3.9A)
CHD  C 307 (-3.9A)
None
None
 0.20A 3abkP-5iy5C:
37.3
3abkW-5iy5C:
undetectable		 3abkP-5iy5C:
100.00
3abkW-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1s TORSIN-1A-INTERACTIN
G PROTEIN 2

(Homo sapiens) 		PF05609
(LAP1C) 		4 LEU B 273
PHE B 298
LEU B 311
PHE B 266
 None
 1.02A 3abkP-5j1sB:
undetectable
3abkW-5j1sB:
undetectable		 3abkP-5j1sB:
21.99
3abkW-5j1sB:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 385
PHE A 434
LEU A 432
PHE A 360
 None
 0.88A 3abkP-5jbgA:
3.1
3abkW-5jbgA:
undetectable		 3abkP-5jbgA:
15.81
3abkW-5jbgA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbw 3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Myxococcus
xanthus) 		PF00378
(ECH_1) 		4 LEU A  31
PHE A  80
LEU A  84
PHE A  88
 None
 0.80A 3abkP-5jbwA:
undetectable
3abkW-5jbwA:
undetectable		 3abkP-5jbwA:
20.91
3abkW-5jbwA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A  82
LEU A  83
PHE A  50
LEU A  54
 None
 0.93A 3abkP-5ju6A:
undetectable
3abkW-5ju6A:
undetectable		 3abkP-5ju6A:
13.89
3abkW-5ju6A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llq METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF01035
(DNA_binding_1) 		4 LEU A  60
PHE A  45
LEU A  49
PHE A  53
 None
 1.01A 3abkP-5llqA:
undetectable
3abkW-5llqA:
undetectable		 3abkP-5llqA:
19.92
3abkW-5llqA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 LEU A 562
PHE A 587
LEU A 527
PHE A 523
 None
 0.87A 3abkP-5lmgA:
3.3
3abkW-5lmgA:
undetectable		 3abkP-5lmgA:
18.33
3abkW-5lmgA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1

(Homo sapiens;
Homo sapiens) 		PF05859
(Mis12)
PF03980
(Nnf1) 		4 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.88A 3abkP-5lskA:
2.7
3abkW-5lskA:
2.7		 3abkP-5lskA:
21.82
3abkW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly8 TAIL COMPONENT

(Lactobacillus
phage J-1) 		no annotation 4 LEU A 153
PHE A 181
LEU A 179
PHE A 201
 None
 0.74A 3abkP-5ly8A:
undetectable
3abkW-5ly8A:
undetectable		 3abkP-5ly8A:
20.48
3abkW-5ly8A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 ARG A  78
LEU A  79
PHE A  46
LEU A  50
 None
 1.01A 3abkP-5nbsA:
undetectable
3abkW-5nbsA:
undetectable		 3abkP-5nbsA:
undetectable
3abkW-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhj GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE

(Streptomyces
sp. CB03234) 		PF00903
(Glyoxalase) 		4 LEU A 121
PHE A 119
PHE A 111
LEU A  88
 None
 0.84A 3abkP-5uhjA:
undetectable
3abkW-5uhjA:
undetectable		 3abkP-5uhjA:
19.14
3abkW-5uhjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umq GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE

(Streptomyces
sp. CB03234) 		no annotation 4 LEU A 121
PHE A 119
PHE A 111
LEU A  88
 None
 0.82A 3abkP-5umqA:
undetectable
3abkW-5umqA:
undetectable		 3abkP-5umqA:
undetectable
3abkW-5umqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 PHE A 167
PHE A  98
LEU A  94
PHE A  89
 None
 0.90A 3abkP-5v0tA:
undetectable
3abkW-5v0tA:
undetectable		 3abkP-5v0tA:
20.08
3abkW-5v0tA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 LEU A 348
PHE A 344
PHE A 380
LEU A 376
 None
 0.76A 3abkP-5xjjA:
3.3
3abkW-5xjjA:
undetectable		 3abkP-5xjjA:
22.22
3abkW-5xjjA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 LEU C1524
PHE C1519
PHE C1563
LEU C1562
 None
 1.02A 3abkP-5y3rC:
undetectable
3abkW-5y3rC:
undetectable		 3abkP-5y3rC:
5.03
3abkW-5y3rC:
1.69