SIMILAR PATTERNS OF AMINO ACIDS FOR 3ABK_J_CHDJ60

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d02 TYPE II RESTRICTION
ENZYME MUNI

(Mycoplasma) 		PF11407
(RestrictionMunI) 		4 ILE A  86
LEU A  42
PHE A  35
LEU A 189
 None
 0.94A 3abkA-1d02A:
undetectable
3abkJ-1d02A:
0.0		 3abkA-1d02A:
17.47
3abkJ-1d02A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1j PROFILIN II

(Homo sapiens) 		PF00235
(Profilin) 		4 PHE A  58
ARG A  74
MET A  85
THR A  84
 None
 0.84A 3abkA-1d1jA:
undetectable
3abkJ-1d1jA:
undetectable		 3abkA-1d1jA:
15.87
3abkJ-1d1jA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		5 ILE A 350
ARG A 308
MET A 311
THR A 312
LEU A 315
 None
 1.16A 3abkA-1floA:
0.0
3abkJ-1floA:
0.0		 3abkA-1floA:
21.78
3abkJ-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.72A 3abkA-1harA:
undetectable
3abkJ-1harA:
0.1		 3abkA-1harA:
18.00
3abkJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ILE A 129
LEU A 181
TYR A 190
LEU A 104
 None
None
None
MLZ  A 105 ( 4.3A)
 0.92A 3abkA-1iv8A:
0.0
3abkJ-1iv8A:
0.0		 3abkA-1iv8A:
20.68
3abkJ-1iv8A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.97A 3abkA-1jedA:
0.0
3abkJ-1jedA:
0.0		 3abkA-1jedA:
21.17
3abkJ-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.81A 3abkA-1kt8A:
0.0
3abkJ-1kt8A:
0.0		 3abkA-1kt8A:
22.71
3abkJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2m REP PROTEIN

(Tomato yellow
leaf curl
Sardinia virus) 		PF00799
(Gemini_AL1) 		4 ILE A   9
PHE A   7
THR A  17
LEU A  16
 None
 0.88A 3abkA-1l2mA:
undetectable
3abkJ-1l2mA:
undetectable		 3abkA-1l2mA:
10.72
3abkJ-1l2mA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ILE A   5
LEU A   8
ARG A 223
THR A 222
 None
 0.93A 3abkA-1mc8A:
undetectable
3abkJ-1mc8A:
0.0		 3abkA-1mc8A:
20.59
3abkJ-1mc8A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		5 ILE D 318
LEU D 321
ARG D 330
THR D 269
LEU D 267
 None
 1.49A 3abkA-1mhzD:
1.7
3abkJ-1mhzD:
undetectable		 3abkA-1mhzD:
21.42
3abkJ-1mhzD:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw5 HYPOTHETICAL PROTEIN
HI1480

(Haemophilus
influenzae) 		no annotation 5 ILE A 135
LEU A  62
PHE A 131
THR A  32
LEU A  34
 None
 1.27A 3abkA-1mw5A:
0.0
3abkJ-1mw5A:
undetectable		 3abkA-1mw5A:
15.69
3abkJ-1mw5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no8 ALY

(Mus musculus) 		PF00076
(RRM_1) 		5 ILE A 121
LEU A 124
PHE A 125
MET A 175
LEU A 170
 None
 1.20A 3abkA-1no8A:
undetectable
3abkJ-1no8A:
undetectable		 3abkA-1no8A:
11.24
3abkJ-1no8A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 PHE A 106
MET A 210
THR A 211
LEU A 214
 HEM  A1407 (-4.5A)
None
None
None
 0.93A 3abkA-1odoA:
0.2
3abkJ-1odoA:
undetectable		 3abkA-1odoA:
23.13
3abkJ-1odoA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		5 ILE A 335
LEU A 339
TYR A 310
ARG A 328
THR A 312
 None
None
None
HG  A 614 ( 4.9A)
None
 1.20A 3abkA-1pm2A:
1.6
3abkJ-1pm2A:
undetectable		 3abkA-1pm2A:
19.19
3abkJ-1pm2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.98A 3abkA-1r6xA:
undetectable
3abkJ-1r6xA:
undetectable		 3abkA-1r6xA:
21.48
3abkJ-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		4 LEU A 261
PHE A 262
THR A 230
LEU A 229
 None
 0.87A 3abkA-1skaA:
undetectable
3abkJ-1skaA:
undetectable		 3abkA-1skaA:
19.89
3abkJ-1skaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uv7 GENERAL SECRETION
PATHWAY PROTEIN M

(Vibrio cholerae) 		PF04612
(T2SSM) 		4 ILE A 143
LEU A 159
ARG A 147
LEU A 120
 None
 0.94A 3abkA-1uv7A:
undetectable
3abkJ-1uv7A:
undetectable		 3abkA-1uv7A:
11.07
3abkJ-1uv7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00215
(OMPdecase) 		4 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.85A 3abkA-1vqtA:
undetectable
3abkJ-1vqtA:
undetectable		 3abkA-1vqtA:
17.18
3abkJ-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 ILE A 250
LEU A 253
ARG A 211
LEU A 204
 None
 0.86A 3abkA-1w1kA:
undetectable
3abkJ-1w1kA:
undetectable		 3abkA-1w1kA:
22.15
3abkJ-1w1kA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn0 HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN

(Zea mays) 		PF01627
(Hpt) 		5 LEU A  30
PHE A  27
MET A 134
THR A 133
LEU A 135
 None
 1.38A 3abkA-1wn0A:
2.8
3abkJ-1wn0A:
undetectable		 3abkA-1wn0A:
13.04
3abkJ-1wn0A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 ILE A 192
LEU A 273
PHE A 274
LEU A 211
 None
 0.79A 3abkA-1xl8A:
2.3
3abkJ-1xl8A:
undetectable		 3abkA-1xl8A:
19.90
3abkJ-1xl8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B

(Homo sapiens) 		PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C) 		4 ILE B 365
PHE B 366
THR B 268
LEU B 267
 None
 0.92A 3abkA-1y8qB:
2.9
3abkJ-1y8qB:
undetectable		 3abkA-1y8qB:
21.77
3abkJ-1y8qB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE

(Moorella
thermoacetica) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ILE A 367
LEU A 340
ARG A 305
LEU A 277
 None
 0.91A 3abkA-1ycgA:
undetectable
3abkJ-1ycgA:
undetectable		 3abkA-1ycgA:
22.05
3abkJ-1ycgA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 LEU A 160
PHE A 165
THR A 138
LEU A 142
 None
 0.91A 3abkA-1ys7A:
undetectable
3abkJ-1ys7A:
undetectable		 3abkA-1ys7A:
18.22
3abkJ-1ys7A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		4 ILE X 178
LEU X 181
ARG X  95
LEU X 102
 None
 0.92A 3abkA-1zv4X:
undetectable
3abkJ-1zv4X:
undetectable		 3abkA-1zv4X:
13.67
3abkJ-1zv4X:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 LEU A 227
TYR A  72
THR A  77
LEU A  80
 None
 0.71A 3abkA-2b9bA:
undetectable
3abkJ-2b9bA:
2.3		 3abkA-2b9bA:
21.63
3abkJ-2b9bA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		4 LEU A  39
PHE A  37
ARG A  21
LEU A  15
 None
 0.90A 3abkA-2cfoA:
undetectable
3abkJ-2cfoA:
undetectable		 3abkA-2cfoA:
21.24
3abkJ-2cfoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cph RNA BINDING MOTIF
PROTEIN 19

(Mus musculus) 		PF00076
(RRM_1) 		4 ILE A 478
LEU A 481
PHE A 482
ARG A 467
 None
 0.91A 3abkA-2cphA:
undetectable
3abkJ-2cphA:
undetectable		 3abkA-2cphA:
12.76
3abkJ-2cphA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36

(Mus musculus) 		PF11605
(Vps36_ESCRT-II) 		5 ILE A  82
LEU A 108
PHE A 110
ARG A 120
LEU A  42
 None
 1.25A 3abkA-2dx5A:
undetectable
3abkJ-2dx5A:
undetectable		 3abkA-2dx5A:
12.45
3abkJ-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		5 ILE A 118
PHE A 126
MET A 167
THR A 165
LEU A 164
 None
 1.46A 3abkA-2g9bA:
undetectable
3abkJ-2g9bA:
undetectable		 3abkA-2g9bA:
16.24
3abkJ-2g9bA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350

(Human
gammaherpesvirus
4) 		PF05109
(Herpes_BLLF1) 		4 PHE A  52
ARG A 107
THR A 105
LEU A 104
 None
 0.89A 3abkA-2h6oA:
undetectable
3abkJ-2h6oA:
undetectable		 3abkA-2h6oA:
23.02
3abkJ-2h6oA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.78A 3abkA-2hnzA:
2.1
3abkJ-2hnzA:
undetectable		 3abkA-2hnzA:
19.77
3abkJ-2hnzA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE A   9
ARG A 108
THR A  43
LEU A  42
 None
 0.90A 3abkA-2idcA:
undetectable
3abkJ-2idcA:
undetectable		 3abkA-2idcA:
13.97
3abkJ-2idcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A  89
ARG A  28
THR A  31
LEU A  33
 None
 0.89A 3abkA-2j3zA:
undetectable
3abkJ-2j3zA:
undetectable		 3abkA-2j3zA:
19.36
3abkJ-2j3zA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjy ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 LEU A  73
ARG A 131
MET A 133
LEU A  84
 None
 0.92A 3abkA-2jjyA:
undetectable
3abkJ-2jjyA:
undetectable		 3abkA-2jjyA:
19.53
3abkJ-2jjyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzn MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT

(Escherichia
coli) 		PF03610
(EIIA-man) 		4 ILE A   3
LEU A 114
PHE A 111
LEU A  65
 None
 0.86A 3abkA-2jznA:
undetectable
3abkJ-2jznA:
undetectable		 3abkA-2jznA:
15.94
3abkJ-2jznA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.83A 3abkA-2kbqA:
undetectable
3abkJ-2kbqA:
undetectable		 3abkA-2kbqA:
8.84
3abkJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2klt SODIUM/CALCIUM
EXCHANGER 1

(Canis lupus) 		PF03160
(Calx-beta) 		4 LEU A 589
PHE A 587
ARG A 574
MET A 521
 None
 0.90A 3abkA-2kltA:
undetectable
3abkJ-2kltA:
undetectable		 3abkA-2kltA:
13.58
3abkJ-2kltA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la7 UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF03724
(META) 		4 LEU A 112
ARG A 117
THR A 137
LEU A 138
 None
 0.93A 3abkA-2la7A:
undetectable
3abkJ-2la7A:
undetectable		 3abkA-2la7A:
14.14
3abkJ-2la7A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lez SECRETED EFFECTOR
PROTEIN PIPB2

(Salmonella
enterica) 		no annotation 4 PHE A 124
MET A  61
THR A  60
LEU A  57
 None
 0.90A 3abkA-2lezA:
undetectable
3abkJ-2lezA:
undetectable		 3abkA-2lezA:
13.68
3abkJ-2lezA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlw EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT 9

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  38
PHE A  42
THR A  91
LEU A  86
 None
 0.94A 3abkA-2nlwA:
undetectable
3abkJ-2nlwA:
undetectable		 3abkA-2nlwA:
12.55
3abkJ-2nlwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		4 ILE A  53
PHE A  79
THR A  97
LEU A  95
 None
 0.93A 3abkA-2o6qA:
undetectable
3abkJ-2o6qA:
undetectable		 3abkA-2o6qA:
18.29
3abkJ-2o6qA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 ILE A  25
LEU A  22
ARG A  54
LEU A  99
 None
 0.91A 3abkA-2ozgA:
undetectable
3abkJ-2ozgA:
undetectable		 3abkA-2ozgA:
21.72
3abkJ-2ozgA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.78A 3abkA-2p0dA:
undetectable
3abkJ-2p0dA:
undetectable		 3abkA-2p0dA:
12.67
3abkJ-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE X 252
MET X 356
THR X 357
LEU X 360
 None
 0.80A 3abkA-2p3gX:
undetectable
3abkJ-2p3gX:
undetectable		 3abkA-2p3gX:
19.81
3abkJ-2p3gX:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 LEU A 128
PHE A 137
TYR A  58
LEU A 163
 None
 0.78A 3abkA-2p3xA:
undetectable
3abkJ-2p3xA:
undetectable		 3abkA-2p3xA:
19.17
3abkJ-2p3xA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 ILE A 250
PHE A 192
ARG A 272
THR A 275
 None
 0.91A 3abkA-2q7sA:
undetectable
3abkJ-2q7sA:
undetectable		 3abkA-2q7sA:
19.19
3abkJ-2q7sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 ILE A 175
PHE A 177
ARG A 165
LEU A 130
 None
 0.93A 3abkA-2qbyA:
undetectable
3abkJ-2qbyA:
undetectable		 3abkA-2qbyA:
20.30
3abkJ-2qbyA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3

(Homo sapiens) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ILE A 272
PHE A 203
THR A  16
LEU A  17
 None
 0.89A 3abkA-2qk4A:
undetectable
3abkJ-2qk4A:
undetectable		 3abkA-2qk4A:
22.52
3abkJ-2qk4A:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 PHE A 347
MET A 334
THR A 335
LEU A 336
 None
 0.86A 3abkA-2uvfA:
undetectable
3abkJ-2uvfA:
undetectable		 3abkA-2uvfA:
22.56
3abkJ-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 4 LEU 1  84
PHE 1 156
THR 1 198
LEU 1 197
 None
 0.89A 3abkA-2ws91:
undetectable
3abkJ-2ws91:
undetectable		 3abkA-2ws91:
19.07
3abkJ-2ws91:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		4 LEU C 309
ARG C 345
THR C 423
LEU C 424
 None
 0.83A 3abkA-2wy0C:
undetectable
3abkJ-2wy0C:
undetectable		 3abkA-2wy0C:
21.21
3abkJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 ILE A 614
LEU A 646
PHE A 612
THR A 753
LEU A 755
 None
 1.23A 3abkA-2wyhA:
2.1
3abkJ-2wyhA:
undetectable		 3abkA-2wyhA:
20.26
3abkJ-2wyhA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE

(Aeromonas
salmonicida) 		PF14521
(Aspzincin_M35) 		4 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.82A 3abkA-2x3cA:
1.5
3abkJ-2x3cA:
undetectable		 3abkA-2x3cA:
20.64
3abkJ-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		4 ILE A 301
LEU A 304
PHE A 305
LEU A 373
 None
 0.90A 3abkA-2xutA:
2.1
3abkJ-2xutA:
undetectable		 3abkA-2xutA:
23.16
3abkJ-2xutA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ILE B 958
LEU B1276
THR B 924
LEU B 925
 None
 0.93A 3abkA-2xwbB:
2.3
3abkJ-2xwbB:
undetectable		 3abkA-2xwbB:
20.77
3abkJ-2xwbB:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		5 LEU A 244
PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.10A 3abkA-2xxlA:
undetectable
3abkJ-2xxlA:
undetectable		 3abkA-2xxlA:
19.17
3abkJ-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 ILE A  75
LEU A  77
THR A  60
LEU A  59
 None
 0.79A 3abkA-2y24A:
undetectable
3abkJ-2y24A:
undetectable		 3abkA-2y24A:
22.63
3abkJ-2y24A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		5 TYR J  32
ARG J  33
MET J  36
THR J  37
LEU J  40
 None
 0.70A 3abkA-2y69J:
undetectable
3abkJ-2y69J:
7.9		 3abkA-2y69J:
10.31
3abkJ-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ARG A 588
MET A 570
THR A 571
LEU A 572
 None
 0.93A 3abkA-2yheA:
undetectable
3abkJ-2yheA:
undetectable		 3abkA-2yheA:
20.41
3abkJ-2yheA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ILE A 617
PHE A 646
THR A 606
LEU A 635
 None
 0.81A 3abkA-2yheA:
undetectable
3abkJ-2yheA:
undetectable		 3abkA-2yheA:
20.41
3abkJ-2yheA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A 193
LEU A  97
PHE A 196
MET A 184
 None
 0.79A 3abkA-2ze0A:
undetectable
3abkJ-2ze0A:
undetectable		 3abkA-2ze0A:
19.59
3abkJ-2ze0A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgk ANTI-TUMOR LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.90A 3abkA-2zgkA:
undetectable
3abkJ-2zgkA:
undetectable		 3abkA-2zgkA:
15.56
3abkJ-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		4 TYR A 471
MET A 475
THR A 476
LEU A 479
 None
 0.81A 3abkA-2ziuA:
undetectable
3abkJ-2ziuA:
undetectable		 3abkA-2ziuA:
18.55
3abkJ-2ziuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.93A 3abkA-2zsgA:
undetectable
3abkJ-2zsgA:
undetectable		 3abkA-2zsgA:
20.79
3abkJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.72A 3abkA-2ztsA:
undetectable
3abkJ-2ztsA:
undetectable		 3abkA-2ztsA:
17.81
3abkJ-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 352
LEU A 377
THR A 348
LEU A 372
 None
 0.85A 3abkA-3b2dA:
undetectable
3abkJ-3b2dA:
undetectable		 3abkA-3b2dA:
20.65
3abkJ-3b2dA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 ILE A 343
LEU A 347
PHE A 344
LEU A 396
 None
 0.84A 3abkA-3b46A:
undetectable
3abkJ-3b46A:
undetectable		 3abkA-3b46A:
22.55
3abkJ-3b46A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 ILE A  66
ARG A 100
THR A  42
LEU A  43
 None
 0.85A 3abkA-3b4uA:
undetectable
3abkJ-3b4uA:
undetectable		 3abkA-3b4uA:
20.99
3abkJ-3b4uA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.32A 3abkA-3b7yA:
undetectable
3abkJ-3b7yA:
undetectable		 3abkA-3b7yA:
13.39
3abkJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 312
TYR A 261
THR A 289
LEU A 346
 None
 0.91A 3abkA-3bn1A:
undetectable
3abkJ-3bn1A:
undetectable		 3abkA-3bn1A:
21.12
3abkJ-3bn1A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
LEU A  62
ARG A  73
LEU A 200
 None
 0.68A 3abkA-3c9bA:
undetectable
3abkJ-3c9bA:
undetectable		 3abkA-3c9bA:
16.41
3abkJ-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 LEU A  53
PHE A  50
ARG A  77
LEU A 115
 None
 0.86A 3abkA-3dbyA:
4.3
3abkJ-3dbyA:
undetectable		 3abkA-3dbyA:
17.09
3abkJ-3dbyA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 LEU A  30
PHE A  32
TYR A 255
THR A 271
 None
 0.73A 3abkA-3dcpA:
undetectable
3abkJ-3dcpA:
undetectable		 3abkA-3dcpA:
19.37
3abkJ-3dcpA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.86A 3abkA-3dy5A:
undetectable
3abkJ-3dy5A:
undetectable		 3abkA-3dy5A:
17.95
3abkJ-3dy5A:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0s UNCHARACTERIZED
PROTEIN

(Chlorobaculum
tepidum) 		PF05235
(CHAD) 		4 PHE A 255
TYR A 347
MET A 351
THR A 352
 None
 0.89A 3abkA-3e0sA:
2.9
3abkJ-3e0sA:
undetectable		 3abkA-3e0sA:
19.13
3abkJ-3e0sA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 ILE A 230
LEU A 231
THR A 219
LEU A 255
 None
 0.76A 3abkA-3e7fA:
undetectable
3abkJ-3e7fA:
undetectable		 3abkA-3e7fA:
19.65
3abkJ-3e7fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehe UDP-GLUCOSE
4-EPIMERASE (GALE-1)

(Archaeoglobus
fulgidus) 		PF01370
(Epimerase) 		4 ILE A 205
ARG A 164
THR A 126
LEU A 271
 None
 0.88A 3abkA-3eheA:
undetectable
3abkJ-3eheA:
undetectable		 3abkA-3eheA:
17.73
3abkJ-3eheA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 5 ILE A 784
PHE A 747
ARG A 721
MET A 720
LEU A 718
 None
 1.49A 3abkA-3f95A:
undetectable
3abkJ-3f95A:
undetectable		 3abkA-3f95A:
17.88
3abkJ-3f95A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		4 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.93A 3abkA-3fddA:
undetectable
3abkJ-3fddA:
undetectable		 3abkA-3fddA:
21.01
3abkJ-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.77A 3abkA-3fg4A:
2.7
3abkJ-3fg4A:
undetectable		 3abkA-3fg4A:
20.56
3abkJ-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ILE A 200
MET A 158
THR A 159
LEU A 160
 None
 0.93A 3abkA-3fssA:
undetectable
3abkJ-3fssA:
undetectable		 3abkA-3fssA:
19.04
3abkJ-3fssA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 165
LEU B  48
ARG B  31
LEU B  36
 None
 0.84A 3abkA-3gzyB:
undetectable
3abkJ-3gzyB:
undetectable		 3abkA-3gzyB:
15.34
3abkJ-3gzyB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 ILE A 147
LEU A 152
THR A 331
LEU A 332
 None
 0.77A 3abkA-3h5tA:
undetectable
3abkJ-3h5tA:
undetectable		 3abkA-3h5tA:
21.02
3abkJ-3h5tA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7a SHORT CHAIN
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00106
(adh_short) 		4 ILE A 135
PHE A 137
THR A  70
LEU A  73
 ILE  A 135 ( 0.6A)
PHE  A 137 ( 1.3A)
THR  A  70 ( 0.8A)
LEU  A  73 ( 0.5A)
 0.89A 3abkA-3h7aA:
undetectable
3abkJ-3h7aA:
undetectable		 3abkA-3h7aA:
18.89
3abkJ-3h7aA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A  15
ARG A  37
THR A  50
LEU A  51
 None
 0.93A 3abkA-3hi8A:
undetectable
3abkJ-3hi8A:
undetectable		 3abkA-3hi8A:
20.53
3abkJ-3hi8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn5 PUTATIVE EXPORTED
PROTEIN BF0290

(Bacteroides
fragilis) 		PF12866
(DUF3823) 		4 ILE A 105
ARG A  36
THR A  34
LEU A  33
 None
 0.84A 3abkA-3hn5A:
undetectable
3abkJ-3hn5A:
undetectable		 3abkA-3hn5A:
17.12
3abkJ-3hn5A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2m ORF59

(Human
gammaherpesvirus
8) 		PF04929
(Herpes_DNAp_acc) 		5 LEU X  98
PHE X  99
ARG X  61
THR X  45
LEU X  66
 None
 1.36A 3abkA-3i2mX:
undetectable
3abkJ-3i2mX:
undetectable		 3abkA-3i2mX:
20.62
3abkJ-3i2mX:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		4 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.92A 3abkA-3iqdB:
undetectable
3abkJ-3iqdB:
undetectable		 3abkA-3iqdB:
21.05
3abkJ-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		5 ILE A  66
LEU A  37
PHE A  68
THR A 262
LEU A 260
 None
 1.04A 3abkA-3ix1A:
undetectable
3abkJ-3ix1A:
undetectable		 3abkA-3ix1A:
19.80
3abkJ-3ix1A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 ILE A 374
LEU A 249
ARG A 245
LEU A 317
 None
 0.82A 3abkA-3j4pA:
undetectable
3abkJ-3j4pA:
undetectable		 3abkA-3j4pA:
22.36
3abkJ-3j4pA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 ILE A  38
LEU A 130
PHE A 131
LEU A 183
 None
 0.88A 3abkA-3j4uA:
undetectable
3abkJ-3j4uA:
undetectable		 3abkA-3j4uA:
21.07
3abkJ-3j4uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		4 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.92A 3abkA-3jzdA:
1.9
3abkJ-3jzdA:
undetectable		 3abkA-3jzdA:
22.15
3abkJ-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ARG A 407
MET A 410
THR A 411
LEU A 414
 None
 0.66A 3abkA-3k13A:
undetectable
3abkJ-3k13A:
undetectable		 3abkA-3k13A:
20.20
3abkJ-3k13A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.87A 3abkA-3k1rA:
undetectable
3abkJ-3k1rA:
undetectable		 3abkA-3k1rA:
14.45
3abkJ-3k1rA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ILE F 166
LEU F 163
ARG F 111
LEU F 153
 None
 0.93A 3abkA-3kfuF:
undetectable
3abkJ-3kfuF:
undetectable		 3abkA-3kfuF:
18.69
3abkJ-3kfuF:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl7 PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Parabacteroides
distasonis) 		PF13483
(Lactamase_B_3) 		4 ILE A 101
MET A 128
THR A 157
LEU A 156
 None
None
GOL  A 306 (-4.7A)
None
 0.90A 3abkA-3kl7A:
undetectable
3abkJ-3kl7A:
undetectable		 3abkA-3kl7A:
16.47
3abkJ-3kl7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.84A 3abkA-3kuqA:
undetectable
3abkJ-3kuqA:
undetectable		 3abkA-3kuqA:
17.51
3abkJ-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		5 ILE A 180
LEU A 192
PHE A 194
ARG A 201
LEU A 207
 None
 1.34A 3abkA-3kzxA:
undetectable
3abkJ-3kzxA:
undetectable		 3abkA-3kzxA:
17.44
3abkJ-3kzxA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 ILE A 283
ARG A 298
THR A 296
LEU A 295
 None
 0.82A 3abkA-3muuA:
undetectable
3abkJ-3muuA:
undetectable		 3abkA-3muuA:
21.45
3abkJ-3muuA:
6.16