SIMILAR PATTERNS OF AMINO ACIDS FOR 3ABK_C_CHDC271_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1) 		4 ARG A  80
GLN A 486
PHE A 491
LEU A 471
 HEM  A1001 (-4.0A)
None
None
None
 1.46A 3abkC-1fftA:
2.7		 3abkC-1fftA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rro RAT ONCOMODULIN

(Rattus rattus) 		PF13499
(EF-hand_7) 		4 ARG A  75
GLN A  71
PHE A  70
LEU A  77
 None
CA  A 135 (-3.3A)
None
None
 1.23A 3abkC-1rroA:
undetectable		 3abkC-1rroA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 ARG B 984
GLN B 950
PHE B 949
LEU B 942
 None
 1.33A 3abkC-1uw4B:
1.1		 3abkC-1uw4B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		4 ARG A 490
GLN A 485
PHE A 482
LEU A 257
 None
 1.07A 3abkC-2nyfA:
3.4		 3abkC-2nyfA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eet PUTATIVE GNTR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
avermitilis) 		PF00392
(GntR)
PF07702
(UTRA) 		4 ARG A 240
GLN A  98
PHE A 139
LEU A 207
 None
 1.05A 3abkC-3eetA:
undetectable		 3abkC-3eetA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
GLN A 193
PHE A 215
LEU A 162
 None
 1.34A 3abkC-3g1zA:
0.3		 3abkC-3g1zA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.20A 3abkC-3k4xA:
0.0		 3abkC-3k4xA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 491
GLN A 505
PHE A 504
LEU A 406
 None
 1.16A 3abkC-3k4xA:
0.0		 3abkC-3k4xA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 758
GLN A 772
PHE A 771
LEU A 673
 None
 1.20A 3abkC-3k4xA:
0.0		 3abkC-3k4xA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 ARG A 102
GLN A 109
PHE A  34
LEU A  98
 None
 1.11A 3abkC-3l8qA:
undetectable		 3abkC-3l8qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 264
GLN A 272
PHE A 274
LEU A 294
 None
 1.17A 3abkC-3nv3A:
undetectable		 3abkC-3nv3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Corynebacterium
diphtheriae) 		PF01625
(PMSR) 		4 ARG A  90
GLN A 134
PHE A  73
LEU A  17
 None
 1.43A 3abkC-4d7lA:
0.2		 3abkC-4d7lA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ARG A 484
GLN A 133
PHE A 134
LEU A 479
 None
 0.95A 3abkC-4jsoA:
0.5		 3abkC-4jsoA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 224
GLN A 238
PHE A 237
LEU A 139
 None
 1.12A 3abkC-4l60A:
undetectable		 3abkC-4l60A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8d SORCIN

(Homo sapiens) 		PF13405
(EF-hand_6)
PF13833
(EF-hand_8) 		4 ARG A  76
GLN A  55
PHE A  70
LEU A  77
 None
 1.28A 3abkC-4u8dA:
undetectable		 3abkC-4u8dA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubs PENTALENIC ACID
SYNTHASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 ARG A 293
GLN A 350
PHE A 344
LEU A 291
 HEM  A 501 (-2.9A)
None
HEM  A 501 (-4.5A)
HEM  A 501 (-3.7A)
 1.49A 3abkC-4ubsA:
0.9		 3abkC-4ubsA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueg GLYCOGENIN-2

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		4 ARG A 119
GLN A 142
PHE A 141
LEU A 185
 None
 1.40A 3abkC-4uegA:
undetectable		 3abkC-4uegA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		4 ARG C 156
GLN C 161
PHE C 164
LEU C 223
 CHD  C 307 (-4.0A)
CHD  C 307 (-4.3A)
CHD  C 307 (-3.9A)
None
 0.54A 3abkC-5iy5C:
37.4		 3abkC-5iy5C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltm PHENYLALANINE
AMMONIA LYASE

(Anabaena) 		no annotation 4 ARG B 490
GLN B 485
PHE B 482
LEU B 257
 None
 1.00A 3abkC-5ltmB:
0.0		 3abkC-5ltmB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 ARG A 123
GLN A 125
PHE A 132
LEU A  66
 None
 1.46A 3abkC-5opjA:
1.7		 3abkC-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxd PEPTIDASE B

(Yersinia pestis) 		no annotation 4 ARG A 104
GLN A  46
PHE A  75
LEU A 101
 SO4  A 501 (-4.5A)
None
None
None
 1.46A 3abkC-6cxdA:
undetectable		 3abkC-6cxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0s TBC1 DOMAIN FAMILY
MEMBER 22B

(Homo sapiens) 		no annotation 4 ARG A 425
GLN A 431
PHE A 437
LEU A 486
 None
 1.06A 3abkC-6d0sA:
undetectable		 3abkC-6d0sA:
undetectable