SIMILAR PATTERNS OF AMINO ACIDS FOR 3A9E_B_REAB1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A 376
ARG A 184
PHE A 207
VAL A 151
LEU A 394
 None
 1.01A 3a9eB-1bqgA:
0.0		 3a9eB-1bqgA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)

(Salmonella
enterica) 		PF00180
(Iso_dh) 		5 LEU A 135
ILE A 134
SER A 254
VAL A 219
LEU A 221
 None
 1.40A 3a9eB-1cnzA:
undetectable		 3a9eB-1cnzA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 PHE A 230
CYH A 237
LEU A 271
ILE A 275
ARG A 278
PHE A 288
SER A 289
PHE A 304
LEU A 400
 961  A 450 (-3.9A)
961  A 450 (-3.6A)
961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-4.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
None
 0.49A 3a9eB-1exxA:
37.9		 3a9eB-1exxA:
77.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		5 PHE A 325
ILE A 262
PHE A 320
PHE A 288
LEU A 330
 None
 1.35A 3a9eB-1fohA:
0.0		 3a9eB-1fohA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 PHE A 402
ILE A 436
PHE A 338
PHE A 422
VAL A 344
 None
 1.27A 3a9eB-1g7cA:
0.0		 3a9eB-1g7cA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 PHE A 701
LEU A 730
ILE A 732
PHE A 746
VAL A 712
 None
 1.21A 3a9eB-1g8xA:
undetectable		 3a9eB-1g8xA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 PHE A 305
ILE A 145
PHE A 269
VAL A  32
LEU A  33
 None
 1.11A 3a9eB-1httA:
0.0		 3a9eB-1httA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4s RIBONUCLEASE III

(Aquifex
aeolicus) 		PF14622
(Ribonucleas_3_3) 		6 PHE A 109
ILE A  51
PHE A  80
SER A  76
PHE A 131
LEU A  11
 None
 1.40A 3a9eB-1i4sA:
2.8		 3a9eB-1i4sA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kps RAN-GTPASE
ACTIVATING PROTEIN 1

(Mus musculus) 		PF07834
(RanGAP1_C) 		6 PHE B 514
LEU B 499
PHE B 509
SER B 466
VAL B 543
LEU B 544
 None
 1.37A 3a9eB-1kpsB:
0.0		 3a9eB-1kpsB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qas PHOSPHOLIPASE C
DELTA-1

(Rattus
norvegicus) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 PHE A 523
SER A 548
PHE A 539
PHE A 504
VAL A 502
 None
 1.40A 3a9eB-1qasA:
undetectable		 3a9eB-1qasA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc7 RIBONUCLEASE III

(Aquifex
aeolicus) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		5 PHE A 109
ILE A  51
PHE A  80
SER A  76
PHE A 131
 None
 1.36A 3a9eB-1rc7A:
undetectable		 3a9eB-1rc7A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc7 RIBONUCLEASE III

(Aquifex
aeolicus) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		5 PHE A 109
ILE A  51
SER A  76
PHE A 131
LEU A  11
 None
 1.23A 3a9eB-1rc7A:
undetectable		 3a9eB-1rc7A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rni ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol) 		5 LEU A 172
ILE A 170
PHE A 162
SER A 240
VAL A 219
 None
 1.35A 3a9eB-1rniA:
undetectable		 3a9eB-1rniA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tme THEILER'S MURINE
ENCEPHALOMYELITIS
VIRUS (SUBUNIT VP2)

(Cardiovirus B) 		PF00073
(Rhv) 		5 LEU 2 194
ILE 2 193
PHE 2 230
SER 2 231
VAL 2 112
 None
 1.23A 3a9eB-1tme2:
undetectable		 3a9eB-1tme2:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		5 LEU A 293
ARG A 242
PHE A 229
VAL A 264
LEU A 220
 None
 1.36A 3a9eB-1v5wA:
undetectable		 3a9eB-1v5wA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 CYH A  62
LEU A  31
ILE A  30
VAL A  10
LEU A   7
 None
 1.40A 3a9eB-1v9lA:
undetectable		 3a9eB-1v9lA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ILE A 266
ARG A 269
PHE A 279
SER A 280
LEU A 213
 TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-4.6A)
TTB  A   1 (-3.1A)
None
 1.30A 3a9eB-1xapA:
37.2		 3a9eB-1xapA:
81.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 PHE A 221
CYH A 228
LEU A 262
ILE A 266
ARG A 269
PHE A 279
SER A 280
PHE A 295
VAL A 388
LEU A 391
 TTB  A   1 (-4.7A)
TTB  A   1 ( 3.8A)
TTB  A   1 (-3.9A)
TTB  A   1 ( 4.0A)
TTB  A   1 (-3.3A)
TTB  A   1 (-4.6A)
TTB  A   1 (-3.1A)
TTB  A   1 ( 4.1A)
TTB  A   1 (-4.3A)
None
 0.49A 3a9eB-1xapA:
37.2		 3a9eB-1xapA:
81.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		5 ILE B 266
ARG B 269
PHE B 279
SER B 280
LEU B 213
 9CR  B 600 ( 3.8A)
9CR  B 600 (-3.8A)
9CR  B 600 (-4.5A)
9CR  B 600 (-3.0A)
None
 1.35A 3a9eB-1xdkB:
37.9		 3a9eB-1xdkB:
77.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		10 PHE B 221
CYH B 228
LEU B 262
ILE B 266
ARG B 269
PHE B 279
SER B 280
PHE B 295
VAL B 388
LEU B 391
 9CR  B 600 ( 4.7A)
9CR  B 600 (-3.4A)
9CR  B 600 (-3.9A)
9CR  B 600 ( 3.8A)
9CR  B 600 (-3.8A)
9CR  B 600 (-4.5A)
9CR  B 600 (-3.0A)
9CR  B 600 (-3.9A)
9CR  B 600 ( 4.6A)
None
 0.42A 3a9eB-1xdkB:
37.9		 3a9eB-1xdkB:
77.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 5 LEU A 461
PHE A 327
PHE A 112
VAL A 120
LEU A 119
 None
 1.12A 3a9eB-2d4yA:
undetectable		 3a9eB-2d4yA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr7 INSULIN RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU A  36
ILE A  13
ARG A  19
VAL A  94
LEU A  93
 None
 1.36A 3a9eB-2hr7A:
undetectable		 3a9eB-2hr7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy8 PROTEIN PM0188

(Pasteurella
multocida) 		PF11477
(PM0188) 		5 SER A 201
ILE A 397
PHE A 359
SER A 360
LEU A 211
 None
 1.39A 3a9eB-2iy8A:
undetectable		 3a9eB-2iy8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 3

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 CYH B  99
LEU B 149
ILE B 180
VAL B 194
LEU B 195
 None
 1.37A 3a9eB-2qbyB:
undetectable		 3a9eB-2qbyB:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 LEU A 250
ILE A 105
PHE A 288
VAL A  17
LEU A  18
 GOL  A 333 ( 4.9A)
None
None
GOL  A 333 (-4.3A)
None
 1.35A 3a9eB-2rbcA:
undetectable		 3a9eB-2rbcA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v95 CORTICOSTEROID-BINDI
NG GLOBULIN

(Rattus
norvegicus) 		PF00079
(Serpin) 		5 SER A  42
ILE A  38
SER A 364
VAL A 168
LEU A 167
 None
 1.40A 3a9eB-2v95A:
undetectable		 3a9eB-2v95A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		5 ARG A 244
PHE A 254
SER A 252
VAL A 170
LEU A 174
 IPE  A1298 (-3.4A)
None
IPE  A1298 (-2.5A)
None
None
 1.23A 3a9eB-2vg2A:
undetectable		 3a9eB-2vg2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whn PILUS ASSEMBLY
PROTEIN PILC

(Thermus
thermophilus) 		PF00482
(T2SSF) 		5 PHE A  70
ILE A 103
PHE A 100
PHE A 127
LEU A 148
 None
 1.22A 3a9eB-2whnA:
undetectable		 3a9eB-2whnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmh FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		5 SER A 171
LEU A 167
ILE A 198
PHE A 204
LEU A 155
 None
 1.35A 3a9eB-2wmhA:
undetectable		 3a9eB-2wmhA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 PHE A 388
LEU A 511
SER A  86
VAL A 460
LEU A 450
 None
 1.40A 3a9eB-2x3kA:
undetectable		 3a9eB-2x3kA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		5 PHE A 236
SER A 187
ILE A 134
PHE A 189
VAL A   5
 None
 1.15A 3a9eB-2za1A:
undetectable		 3a9eB-2za1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 PHE A 334
ARG A 454
SER A 451
PHE A 372
VAL A 401
 None
 1.30A 3a9eB-3a31A:
undetectable		 3a9eB-3a31A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f83 FUSION OF THE MINOR
PILIN CFAE AND MAJOR
PILIN CFAB

(Escherichia
coli) 		PF04449
(Fimbrial_CS1)
PF07434
(CblD) 		5 LEU A 290
ILE A 252
PHE A 239
PHE A 254
LEU A 333
 None
 1.19A 3a9eB-3f83A:
undetectable		 3a9eB-3f83A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbv PUTATIVE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Bacteroides
fragilis) 		PF13407
(Peripla_BP_4) 		5 PHE A 283
LEU A 232
PHE A 252
PHE A 198
LEU A 185
 None
 1.34A 3a9eB-3gbvA:
undetectable		 3a9eB-3gbvA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF01095
(Pectinesterase) 		5 PHE A 272
SER A 303
ILE A 331
PHE A 305
PHE A 286
 None
 1.30A 3a9eB-3grhA:
undetectable		 3a9eB-3grhA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 SER A 189
LEU A 221
ILE A 225
PHE A 199
LEU A 278
 None
 1.33A 3a9eB-3iplA:
undetectable		 3a9eB-3iplA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k77 DNA REPAIR PROTEIN
XRCC1

(Homo sapiens) 		PF01834
(XRCC1_N) 		5 CYH A 132
ILE A  60
PHE A  93
SER A  65
PHE A 111
 None
 1.29A 3a9eB-3k77A:
undetectable		 3a9eB-3k77A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k77 DNA REPAIR PROTEIN
XRCC1

(Homo sapiens) 		PF01834
(XRCC1_N) 		5 ILE A  60
PHE A  93
SER A  65
PHE A 111
VAL A 117
 None
 1.10A 3a9eB-3k77A:
undetectable		 3a9eB-3k77A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Listeria
monocytogenes) 		PF00563
(EAL) 		5 PHE A 171
LEU A 181
ILE A 179
PHE A 176
VAL A 221
 None
None
CL  A 239 (-4.8A)
None
CL  A 236 ( 4.8A)
 1.25A 3a9eB-3kzpA:
undetectable		 3a9eB-3kzpA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvv GLUTAMATE--CYSTEINE
LIGASE

(Saccharomyces
cerevisiae) 		PF03074
(GCS) 		5 ILE A 504
ARG A 538
PHE A 565
VAL A 469
LEU A 448
 None
 1.41A 3a9eB-3lvvA:
undetectable		 3a9eB-3lvvA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1m ORF904

(Sulfolobus
islandicus) 		PF09250
(Prim-Pol)
PF13010
(pRN1_helical) 		5 LEU A 172
ILE A 170
PHE A 162
SER A 240
VAL A 219
 None
 1.33A 3a9eB-3m1mA:
undetectable		 3a9eB-3m1mA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		5 SER A 137
LEU A 435
ILE A 438
ARG A 321
LEU A 164
 None
 1.31A 3a9eB-3mzsA:
2.0		 3a9eB-3mzsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzy RNA POLYMERASE
SIGMA-H FACTOR

(Fusobacterium
nucleatum) 		PF04542
(Sigma70_r2) 		5 ILE A 188
PHE A 150
SER A 151
PHE A 142
VAL A  48
 None
 1.38A 3a9eB-3mzyA:
undetectable		 3a9eB-3mzyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9t PNPC

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		5 PHE A 285
ILE A 186
PHE A 184
PHE A 221
LEU A 255
 None
 1.37A 3a9eB-3n9tA:
undetectable		 3a9eB-3n9tA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4y CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Plasmodium
vivax) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 PHE A 188
ILE A  45
SER A 123
VAL A 150
LEU A 147
 None
 1.07A 3a9eB-3o4yA:
undetectable		 3a9eB-3o4yA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pss QNR

(Aeromonas
hydrophila) 		PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4) 		5 PHE A  47
LEU A  63
PHE A  32
SER A  33
PHE A  42
 None
 1.39A 3a9eB-3pssA:
undetectable		 3a9eB-3pssA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426

(Clostridium
perfringens) 		PF06824
(Glyco_hydro_125) 		5 PHE A  36
ILE A 424
PHE A  32
VAL A  77
LEU A  83
 None
 0.99A 3a9eB-3qt3A:
undetectable		 3a9eB-3qt3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 PHE A 496
ILE A 526
PHE A 514
PHE A 498
VAL A 451
 None
 1.08A 3a9eB-3syjA:
undetectable		 3a9eB-3syjA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w11 INSULIN RECEPTOR
DOMAINS L1-CR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU E  36
ILE E  13
ARG E  19
VAL E  94
LEU E  93
 None
 1.39A 3a9eB-3w11E:
undetectable		 3a9eB-3w11E:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cby HISTONE DEACETYLASE
4

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 PHE A 794
SER A 985
CYH A 982
ILE A 682
SER A 687
 None
 1.23A 3a9eB-4cbyA:
undetectable		 3a9eB-4cbyA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d86 POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		5 LEU A1090
SER A1121
PHE A1129
VAL A1023
LEU A1170
 None
None
None
ADP  A1202 (-3.9A)
None
 1.38A 3a9eB-4d86A:
undetectable		 3a9eB-4d86A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehi BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Campylobacter
jejuni) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 PHE A 231
LEU A 350
ILE A 351
PHE A 226
LEU A 243
 None
 1.25A 3a9eB-4ehiA:
undetectable		 3a9eB-4ehiA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fno PEPTIDYL-TRNA
HYDROLASE

(Pseudomonas
aeruginosa) 		PF01195
(Pept_tRNA_hydro) 		5 LEU A  10
ILE A  64
SER A  75
VAL A 151
LEU A 152
 None
GOL  A 203 (-4.5A)
None
None
None
 1.40A 3a9eB-4fnoA:
undetectable		 3a9eB-4fnoA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 PHE A 359
SER A 358
ILE A 377
PHE A 382
LEU A 324
 None
 1.35A 3a9eB-4fs7A:
undetectable		 3a9eB-4fs7A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 370
PHE A 326
PHE A 380
VAL A  52
LEU A  51
 None
 1.34A 3a9eB-4fwgA:
undetectable		 3a9eB-4fwgA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gq2 NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		5 LEU M 730
ILE M 801
PHE M 773
VAL M 816
LEU M 819
 None
 1.32A 3a9eB-4gq2M:
undetectable		 3a9eB-4gq2M:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ht1 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
12

(Homo sapiens) 		PF00229
(TNF) 		5 LEU T 121
SER T 127
PHE T 148
VAL T 117
LEU T  84
 None
 1.14A 3a9eB-4ht1T:
undetectable		 3a9eB-4ht1T:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		5 PHE A 322
ILE A 405
PHE A 307
SER A 308
PHE A 428
 None
 1.13A 3a9eB-4jrnA:
undetectable		 3a9eB-4jrnA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycobacterium
tuberculosis) 		PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		5 ILE A 379
PHE A  55
SER A  54
PHE A 151
VAL A 129
 None
 1.23A 3a9eB-4kbmA:
undetectable		 3a9eB-4kbmA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		5 LEU A 144
ILE A 156
SER A  38
PHE A 396
LEU A 180
 None
 1.37A 3a9eB-4ke4A:
undetectable		 3a9eB-4ke4A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjr CATION EXCHANGER
YFKE

(Bacillus
subtilis) 		PF01699
(Na_Ca_ex) 		5 ILE A  75
PHE A  78
PHE A 228
VAL A  32
LEU A  29
 None
 1.38A 3a9eB-4kjrA:
undetectable		 3a9eB-4kjrA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18)
PF16403
(DUF5011) 		5 LEU A 104
ILE A 101
PHE A 145
PHE A  97
VAL A  54
 None
 1.31A 3a9eB-4mb5A:
undetectable		 3a9eB-4mb5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN

(Vibrio cholerae) 		PF00165
(HTH_AraC) 		5 LEU A  25
ILE A 222
PHE A 255
SER A 257
VAL A  83
 None
None
None
None
PAM  A 304 ( 4.8A)
 1.41A 3a9eB-4mloA:
undetectable		 3a9eB-4mloA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5j UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 5 LEU A 252
PHE A  83
SER A  80
VAL A  93
LEU A  94
 None
 1.36A 3a9eB-4o5jA:
undetectable		 3a9eB-4o5jA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		5 PHE A 333
SER A 379
ILE A 455
PHE A 246
PHE A 355
 None
 1.26A 3a9eB-4oetA:
undetectable		 3a9eB-4oetA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7o IMMUNITY PROTEIN

(Neisseria
meningitidis) 		no annotation 5 PHE A  24
ILE A  84
PHE A  86
PHE A 108
LEU A  37
 None
 1.23A 3a9eB-4q7oA:
undetectable		 3a9eB-4q7oA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 5 CYH B 340
LEU B 194
PHE B  91
VAL B  98
LEU B  75
 None
 1.03A 3a9eB-4r0mB:
undetectable		 3a9eB-4r0mB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 5 LEU B 194
ILE B 199
PHE B  91
VAL B  98
LEU B  75
 None
 1.20A 3a9eB-4r0mB:
undetectable		 3a9eB-4r0mB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqm URACIL-DNA
GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		5 PHE A 163
PHE A  40
SER A  36
PHE A  64
LEU A 141
 None
 1.10A 3a9eB-4uqmA:
undetectable		 3a9eB-4uqmA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		5 LEU A 104
ILE A 101
PHE A 145
PHE A  97
VAL A  54
 None
None
None
None
CL  A 409 ( 4.0A)
 1.27A 3a9eB-4w5zA:
undetectable		 3a9eB-4w5zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis) 		PF10079
(BshC) 		5 PHE A 523
LEU A 100
ILE A 103
PHE A 520
LEU A   3
 None
 1.28A 3a9eB-4wbdA:
undetectable		 3a9eB-4wbdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wq3 CALPAIN SMALL
SUBUNIT 1

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		5 LEU A 124
ARG A 130
PHE A 226
VAL A 234
LEU A 233
 3SU  A 306 (-4.3A)
3SU  A 305 (-3.3A)
None
None
None
 1.36A 3a9eB-4wq3A:
undetectable		 3a9eB-4wq3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bth DECAPPING NUCLEASE
RAI1

(Candida
albicans) 		PF08652
(RAI1) 		5 ILE A 120
PHE A 359
SER A 358
VAL A 125
LEU A 131
 None
 1.12A 3a9eB-5bthA:
undetectable		 3a9eB-5bthA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN B

(Bacillus
subtilis) 		PF02386
(TrkH) 		5 SER I 137
PHE I 173
PHE I 209
VAL I 130
LEU I 129
 None
 1.34A 3a9eB-5butI:
undetectable		 3a9eB-5butI:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cy4 OLIGORIBONUCLEASE

(Acinetobacter
baumannii) 		PF00929
(RNase_T) 		5 ILE A  33
SER A 103
PHE A  93
VAL A  46
LEU A  47
 None
 1.15A 3a9eB-5cy4A:
undetectable		 3a9eB-5cy4A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czr CADHERIN-RELATED
FAMILY MEMBER 2

(Homo sapiens) 		PF00028
(Cadherin) 		5 PHE A  50
ILE A  77
SER A  43
PHE A  26
LEU A  19
 None
 1.30A 3a9eB-5czrA:
undetectable		 3a9eB-5czrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1v POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		no annotation 5 PHE B 274
SER B 276
LEU B 221
ILE B  64
VAL B 203
 None
 1.36A 3a9eB-5e1vB:
undetectable		 3a9eB-5e1vB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyy CENTROLOBIUM
TOMENTOSUM LECTIN

(Centrolobium
tomentosum) 		PF00139
(Lectin_legB) 		5 LEU A 109
ILE A  89
PHE A 130
VAL A 125
LEU A 126
 None
 1.20A 3a9eB-5eyyA:
undetectable		 3a9eB-5eyyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE

(Plasmodium
falciparum) 		no annotation 5 PHE A 683
CYH A 453
ILE A 467
SER A 457
LEU A 680
 None
 1.23A 3a9eB-5fodA:
undetectable		 3a9eB-5fodA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz1 PROBABLE LRR
RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE
AT4G26540

(Arabidopsis
thaliana) 		PF13855
(LRR_8) 		5 LEU B 314
ILE B 315
PHE B 317
SER B 318
LEU B 264
 None
 1.03A 3a9eB-5hz1B:
undetectable		 3a9eB-5hz1B:
17.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 PHE A 228
CYH A 235
LEU A 269
ILE A 273
ARG A 276
PHE A 286
SER A 287
PHE A 302
VAL A 395
LEU A 398
 6Q7  A 501 (-3.9A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
6Q7  A 501 ( 3.9A)
6Q7  A 501 (-3.2A)
6Q7  A 501 (-4.7A)
6Q7  A 501 (-2.9A)
6Q7  A 501 ( 4.3A)
6Q7  A 501 (-3.5A)
None
 0.67A 3a9eB-5k13A:
36.4		 3a9eB-5k13A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 SER A 232
CYH A 235
LEU A 269
ARG A 276
SER A 287
VAL A 395
LEU A 398
 6Q7  A 501 (-3.7A)
6Q7  A 501 ( 3.7A)
6Q7  A 501 (-3.7A)
6Q7  A 501 (-3.2A)
6Q7  A 501 (-2.9A)
6Q7  A 501 (-3.5A)
None
 0.93A 3a9eB-5k13A:
36.4		 3a9eB-5k13A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m22 HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT

(Sphingomonas
sp. TTNP3) 		no annotation 5 PHE B  88
ILE B 131
PHE B  42
PHE B  65
VAL B 256
 None
 1.39A 3a9eB-5m22B:
undetectable		 3a9eB-5m22B:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 5 PHE A 543
ILE A 478
PHE A 393
PHE A 482
LEU A 374
 None
 1.36A 3a9eB-5ng6A:
undetectable		 3a9eB-5ng6A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		5 ILE C 376
PHE C  52
SER C  51
PHE C 148
VAL C 126
 None
 1.19A 3a9eB-5tw1C:
undetectable		 3a9eB-5tw1C:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A  32
ILE A   9
ARG A  18
VAL A  88
LEU A  87
 None
 1.38A 3a9eB-5u8qA:
undetectable		 3a9eB-5u8qA:
13.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 10 PHE B 221
CYH B 228
LEU B 262
ILE B 266
ARG B 269
PHE B 279
SER B 280
PHE B 295
VAL B 388
LEU B 391
 REA  B 503 ( 4.8A)
REA  B 503 (-3.1A)
REA  B 503 (-3.9A)
REA  B 503 (-3.6A)
REA  B 503 ( 4.8A)
REA  B 503 (-4.4A)
REA  B 503 (-2.1A)
REA  B 503 ( 4.0A)
REA  B 503 ( 4.5A)
None
 0.36A 3a9eB-5uanB:
38.8		 3a9eB-5uanB:
59.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb MINICHROMOSOME
MAINTENANCE PROTEIN
5

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 ILE 5 540
PHE 5 550
SER 5 548
PHE 5 482
LEU 5 449
 None
 1.22A 3a9eB-5udb5:
undetectable		 3a9eB-5udb5:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqi PHOSPHOSUGAR
ISOMERASE

(Escherichia
coli) 		no annotation 5 PHE A  65
LEU A  35
ILE A  36
SER A  41
VAL A 161
 None
 1.10A 3a9eB-5uqiA:
undetectable		 3a9eB-5uqiA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y30 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 5 PHE A  87
SER A  86
ILE A 106
PHE A 111
PHE A  98
 None
 1.37A 3a9eB-5y30A:
undetectable		 3a9eB-5y30A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 LEUCINE-RICH
GLIOMA-INACTIVATED
PROTEIN 1

(Homo sapiens) 		no annotation 5 PHE B  87
SER B  86
ILE B 106
PHE B 111
PHE B  98
 None
 1.39A 3a9eB-5y31B:
undetectable		 3a9eB-5y31B:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ

(Aspergillus
nidulans) 		no annotation 5 PHE B  38
SER B  97
ILE B 103
PHE B 158
LEU B 226
 None
 1.37A 3a9eB-5y7rB:
undetectable		 3a9eB-5y7rB:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb3 -

(-) 		no annotation 5 LEU A 415
ILE A 419
PHE A 335
PHE A 326
LEU A 381
 None
 1.34A 3a9eB-5zb3A:
undetectable		 3a9eB-5zb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 5 PHE I 593
LEU I 526
ILE I 525
PHE I 577
PHE I 543
 None
 1.41A 3a9eB-6bnpI:
undetectable		 3a9eB-6bnpI:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj7 SERPIN-12

(Manduca sexta) 		no annotation 5 LEU A  34
ILE A  33
PHE A 107
SER A 109
LEU A  47
 None
 1.28A 3a9eB-6cj7A:
undetectable		 3a9eB-6cj7A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dd6 PHOTOLYASE PHRB

(Agrobacterium
tumefaciens) 		no annotation 5 LEU A   8
ARG A 108
PHE A 116
VAL A   5
LEU A   4
 DLZ  A 602 (-3.7A)
DLZ  A 602 ( 4.8A)
None
None
None
 1.35A 3a9eB-6dd6A:
undetectable		 3a9eB-6dd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek4 PAXB

(Photorhabdus
luminescens) 		no annotation 5 SER A  64
LEU A 340
SER A 125
VAL A  19
LEU A  22
 None
 1.24A 3a9eB-6ek4A:
undetectable		 3a9eB-6ek4A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 PHE A1653
LEU A1676
ILE A1672
PHE A1739
VAL A1645
 None
 1.34A 3a9eB-6ez8A:
undetectable		 3a9eB-6ez8A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 9 PHE A 230
CYH A 237
LEU A 271
ILE A 275
ARG A 278
PHE A 288
SER A 289
PHE A 304
LEU A 400
 E9T  A 501 (-4.3A)
E9T  A 501 (-3.6A)
E9T  A 501 (-3.6A)
E9T  A 501 (-3.8A)
E9T  A 501 (-3.1A)
E9T  A 501 (-4.7A)
E9T  A 501 (-2.6A)
E9T  A 501 (-4.2A)
None
 0.61A 3a9eB-6fx0A:
38.1		 3a9eB-6fx0A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gw5 -

(-) 		no annotation 5 LEU A 248
PHE A  83
SER A  80
VAL A  93
LEU A  94
 None
 1.26A 3a9eB-6gw5A:
undetectable		 3a9eB-6gw5A:
undetectable