SIMILAR PATTERNS OF AMINO ACIDS FOR 3A51_E_VDYE6178
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ad1 | DIHYDROPTEROATESYNTHETASE (Staphylococcusaureus) |
PF00809(Pterin_bind) | 5 | ASN A 177ILE A 170ALA A 199VAL A 235LEU A 186 | None | 1.13A | 3a51E-1ad1A:0.0 | 3a51E-1ad1A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gff | BACTERIOPHAGE G4CAPSID PROTEINS GPF,GPG, GPJ (Escherichiavirus G4) |
PF02305(Phage_F) | 5 | THR 1 406MET 1 404ILE 1 49ASN 1 409ILE 1 66 | None | 1.07A | 3a51E-1gff1:undetectable | 3a51E-1gff1:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1io0 | TROPOMODULIN (Gallus gallus) |
no annotation | 5 | THR A 234ILE A 264ASN A 201VAL A 273LEU A 285 | None | 1.03A | 3a51E-1io0A:undetectable | 3a51E-1io0A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mpx | ALPHA-AMINO ACIDESTER HYDROLASE (Xanthomonascitri) |
PF02129(Peptidase_S15)PF08530(PepX_C) | 5 | MET A 54ILE A 52ASN A 186VAL A 115LEU A 77 | NoneNoneGOL A3011 (-4.1A)NoneNone | 1.04A | 3a51E-1mpxA:0.0 | 3a51E-1mpxA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nrz | PTS SYSTEM,SORBOSE-SPECIFIC IIBCOMPONENT (Klebsiellapneumoniae) |
PF03830(PTSIIB_sorb) | 5 | MET A 108ILE A 9ILE A 154VAL A 139LEU A 134 | None | 1.18A | 3a51E-1nrzA:undetectable | 3a51E-1nrzA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nvp | TRANSCRIPTIONINITIATION FACTORIIA BETA CHAINTRANSCRIPTIONINITIATION FACTORIIA GAMMA CHAIN (Homo sapiens) |
PF02268(TFIIA_gamma_N)PF02751(TFIIA_gamma_C)PF03153(TFIIA) | 5 | ASN C 359ILE D 44ALA D 43VAL D 36LEU D 15 | None | 1.20A | 3a51E-1nvpC:undetectable | 3a51E-1nvpC:10.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wl7 | ARABINANASE-TS (Geobacillusthermodenitrificans) |
PF04616(Glyco_hydro_43) | 5 | ILE A 282ASN A 263ALA A 273VAL A 39LEU A 298 | None | 1.21A | 3a51E-1wl7A:0.0 | 3a51E-1wl7A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xke | RAN-BINDING PROTEIN2 (Homo sapiens) |
PF00638(Ran_BP1) | 5 | THR A 65ASN A 43ALA A 60VAL A 15LEU A 35 | None | 1.24A | 3a51E-1xkeA:undetectable | 3a51E-1xkeA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y3n | ALGQ1 (Sphingomonassp. A1) |
PF01547(SBP_bac_1) | 5 | MET A 17ILE A 15ALA A 32VAL A 41LEU A 332 | None | 1.07A | 3a51E-1y3nA:undetectable | 3a51E-1y3nA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 5 | ILE A 48ASN A 282ILE A 346PRO A 47LEU A 356 | NoneIMP A 500 ( 4.5A)NoneNoneNone | 1.17A | 3a51E-1zfjA:undetectable | 3a51E-1zfjA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a2a | DEATH-ASSOCIATEDPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 120ILE A 252ALA A 248THR A 244VAL A 291 | NoneNoneNone NA A3178 (-3.0A) NA A3178 ( 4.4A) | 1.15A | 3a51E-2a2aA:undetectable | 3a51E-2a2aA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bb0 | IMIDAZOLONEPROPIONASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 5 | ILE A 338ILE A 353ALA A 356PRO A 295LEU A 346 | None | 1.21A | 3a51E-2bb0A:undetectable | 3a51E-2bb0A:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cun | PHOSPHOGLYCERATEKINASE (Pyrococcushorikoshii) |
PF00162(PGK) | 5 | THR A 69ILE A 87THR A 13VAL A 140LEU A 137 | None | 1.01A | 3a51E-2cunA:undetectable | 3a51E-2cunA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0w | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | THR A 475ALA A 52THR A 59VAL A 63LEU A 66 | None | 1.17A | 3a51E-2e0wA:undetectable | 3a51E-2e0wA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0x | GAMMA-GLUTAMYLTRANSPEPTIDASE (Escherichiacoli) |
PF01019(G_glu_transpept) | 5 | THR B 475ALA A 52THR A 59VAL A 63LEU A 66 | None | 1.12A | 3a51E-2e0xB:undetectable | 3a51E-2e0xB:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g4o | 3-ISOPROPYLMALATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00180(Iso_dh) | 5 | ASN A 262ILE A 6ALA A 7THR A 16VAL A 20 | None | 1.22A | 3a51E-2g4oA:undetectable | 3a51E-2g4oA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2goj | FE-SUPEROXIDEDISMUTASE (Plasmodiumfalciparum) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | ILE A 96MET A 195ILE A 153VAL A 182PRO A 88 | None | 1.17A | 3a51E-2gojA:undetectable | 3a51E-2gojA:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gup | ROK FAMILY PROTEIN (Streptococcuspneumoniae) |
PF00480(ROK) | 5 | ILE A 264ALA A 247VAL A 252PRO A 262LEU A 217 | None | 1.18A | 3a51E-2gupA:undetectable | 3a51E-2gupA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | THR A 80ILE A 35ASN A 96ALA A 161LEU A 25 | NAP A 523 (-3.5A)NAP A 523 (-3.8A)NoneNoneNone | 1.11A | 3a51E-2h2qA:undetectable | 3a51E-2h2qA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hlp | MALATE DEHYDROGENASE (Haloarculamarismortui) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 45ASN A 131ILE A 261ALA A 260THR A 265 | None | 1.08A | 3a51E-2hlpA:undetectable | 3a51E-2hlpA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hrz | NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE (Agrobacteriumfabrum) |
PF01370(Epimerase) | 5 | THR A 133ILE A 13ALA A 12VAL A 39LEU A 28 | None | 1.10A | 3a51E-2hrzA:undetectable | 3a51E-2hrzA:23.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iy4 | NON-HEMEIRON-CONTAININGFERRITIN (Listeriamonocytogenes) |
PF00210(Ferritin) | 5 | MET A 46ILE A 27LYS A 93MET A 95VAL A 84 | None | 1.04A | 3a51E-2iy4A:2.4 | 3a51E-2iy4A:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pkg | SERINE/THREONINE-PROTEIN PHOSPHATASE 2A65 KDA REGULATORYSUBUNIT A ALPHAISOFORM (Homo sapiens) |
PF02985(HEAT)PF13646(HEAT_2) | 5 | ASN A 22ILE A 38ALA A 39THR A 47LEU A 55 | None | 1.04A | 3a51E-2pkgA:undetectable | 3a51E-2pkgA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pnn | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY VMEMBER 1 (Rattusnorvegicus) |
PF12796(Ank_2) | 5 | THR A 156ILE A 173ILE A 207ALA A 208LEU A 165 | THR A 156 ( 0.8A)ILE A 173 ( 0.6A)ILE A 207 ( 0.7A)ALA A 208 ( 0.0A)LEU A 165 ( 0.6A) | 1.18A | 3a51E-2pnnA:undetectable | 3a51E-2pnnA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qae | DIHYDROLIPOYLDEHYDROGENASE (Trypanosomacruzi) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | THR A 137ILE A 8ALA A 143VAL A 296LEU A 283 | NoneFAD A 480 (-4.7A)NoneNoneNone | 1.15A | 3a51E-2qaeA:undetectable | 3a51E-2qaeA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qhs | LIPOYLTRANSFERASE (Thermusthermophilus) |
PF03099(BPL_LplA_LipB) | 5 | THR A 80ASN A 156ALA A 143VAL A 99LEU A 103 | OCA A3913 ( 3.8A)NoneNoneNoneNone | 1.22A | 3a51E-2qhsA:undetectable | 3a51E-2qhsA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qhu | LIPOYLTRANSFERASE (Thermusthermophilus) |
PF03099(BPL_LplA_LipB) | 5 | THR A 80ASN A 156ALA A 143VAL A 99LEU A 103 | OYA A1001 ( 4.0A)NoneNoneNoneNone | 1.22A | 3a51E-2qhuA:undetectable | 3a51E-2qhuA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vli | ANTIBIOTICRESISTANCE PROTEIN (Deinococcusradiodurans) |
no annotation | 5 | ILE A 81ILE A 165ALA A 162PRO A 79LEU A 171 | None | 1.22A | 3a51E-2vliA:undetectable | 3a51E-2vliA:20.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xkr | PUTATIVE CYTOCHROMEP450 142 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | MET A 74ILE A 76ILE A 229THR A 234VAL A 277 | PG4 A1399 ( 4.4A)HEM A1400 (-4.1A)PG4 A1399 ( 4.5A)HEM A1400 (-3.7A)HEM A1400 (-4.5A) | 0.67A | 3a51E-2xkrA:45.2 | 3a51E-2xkrA:35.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xr1 | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR100 KD SUBUNIT (Methanosarcinamazei) |
PF07521(RMMBL)PF07650(KH_2)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | THR A 60ILE A 51THR A 38VAL A 22LEU A 18 | None | 1.23A | 3a51E-2xr1A:undetectable | 3a51E-2xr1A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yab | DEATH-ASSOCIATEDPROTEIN KINASE 2 (Mus musculus) |
PF00069(Pkinase) | 5 | ILE A 120ILE A 252ALA A 248THR A 244VAL A 291 | None | 1.17A | 3a51E-2yabA:undetectable | 3a51E-2yabA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yn3 | PUTATIVE INNERMEMBRANE PROTEIN (Salmonellaenterica) |
PF12245(Big_3_2) | 5 | ILE A5255ILE A5180ALA A5345PRO A5186LEU A5167 | None CA A6363 (-4.8A)NoneNoneNone | 1.22A | 3a51E-2yn3A:undetectable | 3a51E-2yn3A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zbm | PROTEIN-TYROSINE-PHOSPHATASE (Shewanella sp.) |
PF00149(Metallophos) | 5 | THR A 53ILE A 187ASN A 101ILE A 59LEU A 145 | None | 1.21A | 3a51E-2zbmA:undetectable | 3a51E-2zbmA:22.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zbz | CYTOCHROME P450-SU1 (Streptomycesgriseolus) |
PF00067(p450) | 5 | ILE A 96ASN A 194ILE A 243ALA A 244THR A 248 | HEM A 413 (-4.0A)NoneVDX A 501 (-4.2A)HEM A 413 (-3.5A)HEM A 413 (-3.2A) | 1.07A | 3a51E-2zbzA:47.7 | 3a51E-2zbzA:37.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aeh | HEMOGLOBIN-BINDINGPROTEASE HBPAUTOTRANSPORTER (Escherichiacoli) |
PF03797(Autotransporter) | 5 | THR A1166ILE A1096THR A1311VAL A1276LEU A1255 | None | 0.95A | 3a51E-3aehA:undetectable | 3a51E-3aehA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cm1 | SSGA-LIKESPORULATION-SPECIFICCELL DIVISIONPROTEIN (Thermobifidafusca) |
PF04686(SsgA) | 5 | ILE A 89ILE A 40ALA A 42VAL A 12LEU A 107 | None | 1.18A | 3a51E-3cm1A:undetectable | 3a51E-3cm1A:18.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ejb | BIOTIN BIOSYNTHESISCYTOCHROME P450-LIKEENZYME (Bacillussubtilis) |
PF00067(p450) | 5 | MET B 79ASN B 181ILE B 233ALA B 234THR B 238 | NoneNoneNoneHEM B 405 (-3.5A)HEM B 405 (-3.7A) | 0.67A | 3a51E-3ejbB:47.4 | 3a51E-3ejbB:36.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epm | THIAMINEBIOSYNTHESIS PROTEINTHIC (Caulobactervibrioides) |
PF01964(ThiC_Rad_SAM)PF13667(ThiC-associated) | 5 | ILE A 193ASN A 219MET A 248ALA A 196VAL A 149 | None | 1.01A | 3a51E-3epmA:undetectable | 3a51E-3epmA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gp0 | MITOGEN-ACTIVATEDPROTEIN KINASE 11 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 96ALA A 93THR A 91VAL A 345LEU A 346 | None | 1.03A | 3a51E-3gp0A:undetectable | 3a51E-3gp0A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvh | MALATE DEHYDROGENASE (Brucellaabortus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 240ASN A 121ILE A 117VAL A 30LEU A 8 | NoneNAD A 400 (-3.6A)NoneNoneNone | 1.23A | 3a51E-3gvhA:undetectable | 3a51E-3gvhA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5o | TRANSCRIPTIONALREGULATOR GNTR (Chromobacteriumviolaceum) |
PF13377(Peripla_BP_3) | 5 | THR A 133MET A 155ILE A 305ASN A 107ILE A 92 | NoneNoneNoneSO4 A 1 (-3.2A)None | 1.17A | 3a51E-3h5oA:undetectable | 3a51E-3h5oA:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7f | SERINEHYDROXYMETHYLTRANSFERASE 1 (Mycobacteriumtuberculosis) |
PF00464(SHMT) | 5 | MET A 29ILE A 364ALA A 383VAL A 302LEU A 390 | None | 1.17A | 3a51E-3h7fA:undetectable | 3a51E-3h7fA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpd | HYDROXYETHYLTHIAZOLEKINASE (Pyrococcushorikoshii) |
PF02110(HK) | 5 | ILE A 124ALA A 155THR A 160VAL A 114LEU A 110 | None | 1.17A | 3a51E-3hpdA:undetectable | 3a51E-3hpdA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ijl | MUCONATECYCLOISOMERASE (Bacteroidesthetaiotaomicron) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 78ILE A 143ALA A 140VAL A 127LEU A 124 | None | 0.98A | 3a51E-3ijlA:undetectable | 3a51E-3ijlA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j4j | TRANSLATIONINITIATION FACTORIF-2 (Thermusthermophilus) |
PF00009(GTP_EFTU)PF04760(IF2_N)PF11987(IF-2) | 5 | ILE A 182ILE A 213ALA A 178VAL A 192PRO A 189 | None | 1.09A | 3a51E-3j4jA:undetectable | 3a51E-3j4jA:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8p | DSL1 (Kluyveromyceslactis) |
PF11989(Dsl1_C) | 5 | THR C 633ILE C 600THR C 541VAL C 522LEU C 526 | None | 1.05A | 3a51E-3k8pC:undetectable | 3a51E-3k8pC:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh5 | PROTEIN MJ1225 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 269ALA A 236VAL A 233PRO A 183LEU A 190 | ADP A 284 ( 4.3A)NoneAMP A 282 (-3.8A)NoneNone | 0.93A | 3a51E-3kh5A:undetectable | 3a51E-3kh5A:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kpb | UNCHARACTERIZEDPROTEIN MJ0100 (Methanocaldococcusjannaschii) |
PF00571(CBS) | 5 | ILE A 495ALA A 462VAL A 459PRO A 423LEU A 431 | NoneNoneSAM A1000 ( 3.9A)NoneNone | 0.99A | 3a51E-3kpbA:undetectable | 3a51E-3kpbA:14.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o44 | HEMOLYSIN (Vibrio cholerae) |
PF07968(Leukocidin)PF12563(Hemolysin_N)PF16458(Beta-prism_lec) | 5 | ILE A 209ILE A 402ALA A 260THR A 399VAL A 448 | None | 1.08A | 3a51E-3o44A:undetectable | 3a51E-3o44A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ot5 | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Listeriamonocytogenes) |
PF02350(Epimerase_2) | 5 | THR A 36ILE A 9ILE A 86ALA A 109LEU A 117 | None | 1.09A | 3a51E-3ot5A:undetectable | 3a51E-3ot5A:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pen | TRANSLATIONINITIATION FACTOR 2SUBUNIT GAMMA (Sulfolobussolfataricus) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF09173(eIF2_C) | 5 | ASN A 55ILE A 12ALA A 114VAL A 147LEU A 194 | None | 1.21A | 3a51E-3penA:undetectable | 3a51E-3penA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zh2 | L-LACTATEDEHYDROGENASE (Plasmodiumfalciparum) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 244ASN A 127ILE A 123VAL A 31LEU A 9 | None | 1.18A | 3a51E-3zh2A:undetectable | 3a51E-3zh2A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a9a | RIBOSOME-INTERACTINGGTPASE 1 (Saccharomycescerevisiae) |
PF01926(MMR_HSR1)PF02824(TGS)PF16897(MMR_HSR1_Xtn) | 5 | ILE A 56ASN A 174ALA A 138VAL A 101LEU A 119 | None | 1.05A | 3a51E-4a9aA:2.7 | 3a51E-4a9aA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ad9 | BETA-LACTAMASE-LIKEPROTEIN 2 (Homo sapiens) |
PF00753(Lactamase_B) | 5 | ILE A 93ILE A 73THR A 33VAL A 18LEU A 35 | None | 1.21A | 3a51E-4ad9A:undetectable | 3a51E-4ad9A:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4arc | LEUCINE--TRNA LIGASE (Escherichiacoli) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1)PF13603(tRNA-synt_1_2) | 5 | ILE A 232ASN A 383ILE A 399ALA A 400PRO A 312 | None | 1.22A | 3a51E-4arcA:undetectable | 3a51E-4arcA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b43 | TRANSLATIONINITIATION FACTORIF-2 (Thermusthermophilus) |
PF00009(GTP_EFTU)PF04760(IF2_N) | 5 | ILE A 182ILE A 213ALA A 178VAL A 192PRO A 189 | None | 1.21A | 3a51E-4b43A:undetectable | 3a51E-4b43A:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8b | GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 1 (Saccharomycescerevisiae) |
PF16417(CNOT1_TTP_bind)PF16418(CNOT1_HEAT)PF16419(CNOT1_HEAT_N) | 5 | ILE A 455ILE A 490ALA A 487VAL A 471LEU A 462 | None AU A1749 (-4.6A)NoneNoneNone | 1.11A | 3a51E-4b8bA:undetectable | 3a51E-4b8bA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d7a | TRNATHREONYLCARBAMOYLADENOSINE DEHYDRATASE (Escherichiacoli) |
PF00899(ThiF) | 5 | ILE A 129ALA A 128THR A 152VAL A 150LEU A 149 | AMP A 401 (-4.1A)NoneNoneNoneGOL A 502 (-4.7A) | 1.14A | 3a51E-4d7aA:undetectable | 3a51E-4d7aA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gxz | SUPPRESSION OFCOPPER SENSITIVITYPROTEIN (Salmonellaenterica) |
PF01323(DSBA) | 5 | ILE A 119ALA A 89THR A 92VAL A 131LEU A 133 | None | 1.21A | 3a51E-4gxzA:undetectable | 3a51E-4gxzA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h08 | PUTATIVE HYDROLASE (Bacteroidesthetaiotaomicron) |
PF00657(Lipase_GDSL) | 5 | ILE A 177ASN A 51ILE A 101ALA A 135VAL A 220 | NoneUNL A 301 ( 3.5A)NoneNoneNone | 1.21A | 3a51E-4h08A:undetectable | 3a51E-4h08A:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ii3 | UBIQUITIN-60SRIBOSOMAL PROTEINL40 (Schizosaccharomycespombe) |
PF00240(ubiquitin) | 5 | THR B 9ILE B 13ILE B 36VAL B 26LEU B 43 | None | 1.14A | 3a51E-4ii3B:undetectable | 3a51E-4ii3B:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iuy | SHORT CHAINDEHYDROGENASE/REDUCTASE (Acinetobacterbaumannii) |
PF00106(adh_short) | 5 | THR A 14ILE A 142ALA A 186VAL A 246LEU A 224 | None | 1.21A | 3a51E-4iuyA:undetectable | 3a51E-4iuyA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 5 | ASN A 39ILE A 499THR A 483VAL A 510PRO A 506 | None | 1.04A | 3a51E-4ph9A:2.1 | 3a51E-4ph9A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4plh | MALATE DEHYDROGENASE (Apicomplexa) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 241ASN A 122ILE A 118VAL A 31LEU A 9 | NoneOXM A 401 ( 3.3A)NoneNoneNone | 1.19A | 3a51E-4plhA:undetectable | 3a51E-4plhA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qhi | UNCHARACTERIZEDPROTEIN MJ1213 (Methanocaldococcusjannaschii) |
PF01435(Peptidase_M48) | 5 | THR A 14ILE A 29ILE A 66ALA A 39LEU A 55 | None | 1.11A | 3a51E-4qhiA:undetectable | 3a51E-4qhiA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rwt | LEIOMODIN-2 (Homo sapiens) |
no annotation | 5 | ILE C 248ASN C 185ILE C 228ALA C 229LEU C 269 | None | 1.06A | 3a51E-4rwtC:undetectable | 3a51E-4rwtC:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rwt | LEIOMODIN-2 (Homo sapiens) |
no annotation | 5 | ILE C 253ASN C 217ILE C 228ALA C 229LEU C 269 | None | 1.13A | 3a51E-4rwtC:undetectable | 3a51E-4rwtC:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rwt | LEIOMODIN-2 (Homo sapiens) |
no annotation | 5 | THR C 218ILE C 248ASN C 185ILE C 228LEU C 269 | None | 0.86A | 3a51E-4rwtC:undetectable | 3a51E-4rwtC:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x6k | ANHYDROSIALIDASE ([Ruminococcus]gnavus) |
PF13088(BNR_2) | 5 | THR A 681ILE A 270ALA A 292PRO A 340LEU A 353 | None | 1.09A | 3a51E-4x6kA:undetectable | 3a51E-4x6kA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xkj | D-LACTATEDEHYDROGENASE (Sporolactobacillusinulinus) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | THR A 38ILE A 4ASN A 58ILE A 50VAL A 315 | None | 0.89A | 3a51E-4xkjA:undetectable | 3a51E-4xkjA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xri | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 5 | ILE A 368ILE A 373VAL A 406PRO A 402LEU A 407 | None | 1.10A | 3a51E-4xriA:undetectable | 3a51E-4xriA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z79 | LEIOMODIN-1ACTIN-BINDING SITE 2(ABS2) (Homo sapiens) |
no annotation | 5 | ILE A 399ASN A 336ILE A 379ALA A 380LEU A 420 | NoneGOL A 505 (-4.2A)NoneGOL A 502 (-3.6A)None | 1.06A | 3a51E-4z79A:undetectable | 3a51E-4z79A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z79 | LEIOMODIN-1ACTIN-BINDING SITE 2(ABS2) (Homo sapiens) |
no annotation | 5 | THR A 369ILE A 399ASN A 336ILE A 379LEU A 420 | NoneNoneGOL A 505 (-4.2A)NoneNone | 0.88A | 3a51E-4z79A:undetectable | 3a51E-4z79A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8g | TROPOMODULIN-1,LEIOMODIN-1 CHIMERA(TP1 ABS2) (Homo sapiens) |
no annotation | 5 | ILE A 399ASN A 201ILE A 379ALA A 380LEU A 420 | None NI A 509 (-4.0A)NoneNoneNone | 0.96A | 3a51E-4z8gA:undetectable | 3a51E-4z8gA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8g | TROPOMODULIN-1,LEIOMODIN-1 CHIMERA(TP1 ABS2) (Homo sapiens) |
no annotation | 5 | THR A 369ILE A 399ASN A 201ILE A 379LEU A 420 | NoneNone NI A 509 (-4.0A)NoneNone | 0.80A | 3a51E-4z8gA:undetectable | 3a51E-4z8gA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z94 | GELSOLIN,TROPOMODULIN-1,LEIOMODIN-1 CHIMERA (Homo sapiens) |
PF00626(Gelsolin) | 5 | ILE G1399ASN G1201ILE G1379ALA G1380LEU G1420 | None | 1.08A | 3a51E-4z94G:undetectable | 3a51E-4z94G:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z94 | GELSOLIN,TROPOMODULIN-1,LEIOMODIN-1 CHIMERA (Homo sapiens) |
PF00626(Gelsolin) | 5 | THR G1369ILE G1399ASN G1201ILE G1379LEU G1420 | None | 0.90A | 3a51E-4z94G:undetectable | 3a51E-4z94G:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b16 | RIBONUCLEASE3,DROSHA,RIBONUCLEASE3,DROSHA,RIBONUCLEASE 3 (Homo sapiens) |
PF00035(dsrm)PF00636(Ribonuclease_3)PF14622(Ribonucleas_3_3) | 6 | THR A 416ILE A 702LYS A 694THR A 590VAL A 856PRO A 683 | None | 1.18A | 3a51E-5b16A:undetectable | 3a51E-5b16A:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b83 | TETRA UBIQUITIN (Homo sapiens) |
PF00240(ubiquitin) | 5 | THR A 85ILE A 89ILE A 112VAL A 102LEU A 119 | None | 1.16A | 3a51E-5b83A:undetectable | 3a51E-5b83A:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cl2 | SPORULATION-CONTROLPROTEIN SPO0M (Bacillussubtilis) |
PF07070(Spo0M) | 5 | ILE A 74ILE A 132ALA A 113VAL A 110PRO A 104 | None | 1.14A | 3a51E-5cl2A:undetectable | 3a51E-5cl2A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cxu | FERULIC ACIDESTERASE AMCE1/FAE1A (Anaeromycesmucronatus) |
PF00756(Esterase) | 5 | MET A 134ILE A 133ILE A 165PRO A 99LEU A 62 | None | 1.23A | 3a51E-5cxuA:undetectable | 3a51E-5cxuA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fav | CHOLINETRIMETHYLAMINE-LYASE (Desulfovibrioalaskensis) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | ILE A 338ILE A 317VAL A 422PRO A 430LEU A 371 | None | 1.24A | 3a51E-5favA:undetectable | 3a51E-5favA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fku | DNA POLYMERASE IIISUBUNIT ALPHA (Escherichiacoli) |
PF01336(tRNA_anti-codon)PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 5 | ILE A 835ILE A 816ALA A 887VAL A 878LEU A 874 | None | 1.22A | 3a51E-5fkuA:3.1 | 3a51E-5fkuA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g5f | TAU CLASSGLUTATHIONES-TRANSFERASE (Mangiferaindica) |
PF00043(GST_C)PF02798(GST_N) | 5 | LYS A 27ILE A 161ALA A 162PRO A 87LEU A 86 | NoneNoneNonePEG A1226 (-3.4A)None | 1.17A | 3a51E-5g5fA:undetectable | 3a51E-5g5fA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gl9 | BETA-LACTAMASE (Burkholderiathailandensis) |
PF13354(Beta-lactamase2) | 5 | THR A 109MET A 117ALA A 140VAL A 148LEU A 76 | None | 1.12A | 3a51E-5gl9A:undetectable | 3a51E-5gl9A:22.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 7 | THR A 84MET A 86ILE A 88ILE A 235THR A 240VAL A 283PRO A 287 | NoneNoneHEM A 501 ( 4.4A)NoneHEM A 501 (-3.7A)HEM A 501 (-4.7A)HEM A 501 (-3.5A) | 0.66A | 3a51E-5gnmA:56.4 | 3a51E-5gnmA:98.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 6 | THR A 84MET A 86ILE A 235ALA A 236THR A 240VAL A 283 | NoneNoneNoneHEM A 501 (-3.6A)HEM A 501 (-3.7A)HEM A 501 (-4.7A) | 0.95A | 3a51E-5gnmA:56.4 | 3a51E-5gnmA:98.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jow | NON-REDUCING ENDALPHA-L-ARABINOFURANOSIDASE BOGH43A (Bacteroidesovatus) |
PF04616(Glyco_hydro_43) | 5 | THR A 183ILE A 217ALA A 254VAL A 290PRO A 298 | None | 1.23A | 3a51E-5jowA:undetectable | 3a51E-5jowA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jwf | ASP/GLU-SPECIFICDIPEPTIDYL-PEPTIDASE (Porphyromonasgingivalis) |
PF10459(Peptidase_S46) | 5 | ILE A 397ILE A 405ALA A 408PRO A 474LEU A 477 | None | 1.15A | 3a51E-5jwfA:undetectable | 3a51E-5jwfA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kia | L-THREONINE3-DEHYDROGENASE (Burkholderiathailandensis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | THR A 294ILE A 182ALA A 179VAL A 167LEU A 162 | None | 1.11A | 3a51E-5kiaA:undetectable | 3a51E-5kiaA:24.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l94 | CYTOCHROME P450 (Bacillusmegaterium) |
PF00067(p450) | 6 | ILE A 85LYS A 187ILE A 241ALA A 242THR A 246VAL A 289 | HEM A 501 (-4.4A)NoneTES A 502 (-4.0A)HEM A 501 (-3.5A)HEM A 501 (-3.4A)TES A 502 (-4.8A) | 0.46A | 3a51E-5l94A:49.7 | 3a51E-5l94A:34.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ulv | MALATE DEHYDROGENASE (Methylobacteriumextorquens) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 240ASN A 121ILE A 117VAL A 30LEU A 8 | None | 1.22A | 3a51E-5ulvA:undetectable | 3a51E-5ulvA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um6 | UBIQUITIN-ACTIVATINGENZYME E1 1 (Schizosaccharomycespombe) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 5 | ILE A 162ILE A 52ALA A 366THR A 857VAL A 861 | None | 1.24A | 3a51E-5um6A:2.3 | 3a51E-5um6A:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vip | MDCDMDCE (Pseudomonasaeruginosa) |
PF01039(Carboxyl_trans)PF06833(MdcE) | 5 | THR B 118ILE B 136ALA B 134VAL A 119LEU B 169 | None | 1.17A | 3a51E-5vipB:undetectable | 3a51E-5vipB:25.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1j | THIOREDOXINGLUTATHIONEREDUCTASE (Echinococcusgranulosus) |
no annotation | 6 | THR A 250ASN A 247ILE A 115ALA A 256VAL A 414LEU A 402 | NoneNoneFAD A 601 (-4.7A)NoneNoneNone | 1.42A | 3a51E-5w1jA:undetectable | 3a51E-5w1jA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtb | NADH-UBIQUINONEOXIDOREDUCTASE 75KDA SUBUNIT,MITOCHONDRIAL (Homo sapiens) |
PF00384(Molybdopterin)PF09326(NADH_dhqG_C)PF10588(NADH-G_4Fe-4S_3)PF13510(Fer2_4) | 5 | ILE M 418ILE M 391VAL M 475PRO M 407LEU M 516 | None | 1.07A | 3a51E-5xtbM:undetectable | 3a51E-5xtbM:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvm | STEROL3-BETA-GLUCOSYLTRANSFERASE (Saccharomycescerevisiae) |
PF00201(UDPGT)PF03033(Glyco_transf_28) | 5 | THR A 960ILE A1148ILE A1155VAL A 770LEU A 744 | None | 1.08A | 3a51E-5xvmA:undetectable | 3a51E-5xvmA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yj6 | DOCKERIN TYPE IREPEAT-CONTAININGPROTEIN (Ruminiclostridiumthermocellum) |
no annotation | 5 | LYS A 468ASN A 464ILE A 398PRO A 497LEU A 510 | None | 1.22A | 3a51E-5yj6A:undetectable | 3a51E-5yj6A:11.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ysm | CYTOCHROME P450 (Amycolatopsismediterranei) |
no annotation | 5 | ILE A 107ILE A 255ALA A 256THR A 260VAL A 303 | HEM A 501 (-4.2A)NoneHEM A 501 (-3.4A)HEM A 501 (-3.7A)None | 0.93A | 3a51E-5ysmA:39.3 | 3a51E-5ysmA:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b5f | NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE (Yersiniaenterocolitica) |
no annotation | 5 | ILE A 285ALA A 330VAL A 57PRO A 258LEU A 52 | None | 1.12A | 3a51E-6b5fA:undetectable | 3a51E-6b5fA:22.02 |