SIMILAR PATTERNS OF AMINO ACIDS FOR 3A51_D_VDYD6178

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE


(Trypanosoma
brucei)
PF00162
(PGK)
5 ILE A 180
MET A  71
ILE A 154
VAL A  58
LEU A 131
None
1.19A 3a51D-13pkA:
0.0
3a51D-13pkA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 MET A 342
ILE A 353
ASN A 272
LEU A 340
ILE A 223
None
1.21A 3a51D-1h6dA:
0.0
3a51D-1h6dA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm6 ANNEXIN 1

(Sus scrofa)
PF00191
(Annexin)
5 LEU A 256
ILE A 260
THR A 265
VAL A 268
LEU A 225
None
1.21A 3a51D-1hm6A:
0.0
3a51D-1hm6A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io0 TROPOMODULIN

(Gallus gallus)
no annotation 5 THR A 234
ILE A 264
ASN A 201
VAL A 273
LEU A 285
None
1.03A 3a51D-1io0A:
0.0
3a51D-1io0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmo HEPARIN COFACTOR II

(Homo sapiens)
PF00079
(Serpin)
5 ILE A 270
LEU A 205
ILE A 408
VAL A 158
LEU A 398
None
0.95A 3a51D-1jmoA:
0.0
3a51D-1jmoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT


(Klebsiella
pneumoniae)
PF08841
(DDR)
5 THR A  37
ILE A  46
LEU A  50
VAL A 387
LEU A  72
None
1.04A 3a51D-1nbwA:
0.0
3a51D-1nbwA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE


(Homo sapiens)
PF01182
(Glucosamine_iso)
5 ILE A  20
MET A  89
LEU A  52
VAL A 238
LEU A 202
None
1.24A 3a51D-1ne7A:
0.0
3a51D-1ne7A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1)
PF03122
(Herpes_MCP)
5 ILE A 937
LEU A 939
ILE A 949
VAL A 835
LEU A 629
None
1.23A 3a51D-1no7A:
0.0
3a51D-1no7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT


(Klebsiella
pneumoniae)
PF03830
(PTSIIB_sorb)
5 MET A 108
ILE A   9
ILE A 154
VAL A 139
LEU A 134
None
1.20A 3a51D-1nrzA:
0.0
3a51D-1nrzA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE


(Thermotoga
maritima)
PF00171
(Aldedh)
5 THR A 292
ILE A 275
LEU A 261
ILE A 316
THR A 249
None
1.18A 3a51D-1o20A:
undetectable
3a51D-1o20A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE


(Lachancea
kluyveri)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ILE A 432
ASN A 422
LEU A 128
ILE A 127
LEU A  40
None
1.16A 3a51D-1r3nA:
undetectable
3a51D-1r3nA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3d ARSENATE REDUCTASE

(Escherichia
coli)
PF03960
(ArsC)
5 ILE A  92
LEU A  58
ILE A  48
THR A 103
PRO A  39
None
1.16A 3a51D-1s3dA:
undetectable
3a51D-1s3dA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
5 MET A 635
ILE A 632
LEU A 637
THR A 739
LEU A 712
None
1.18A 3a51D-1suvA:
undetectable
3a51D-1suvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis)
PF00296
(Bac_luciferase)
5 ILE A 374
LEU A 407
ILE A 404
VAL A 275
PRO A 273
None
1.15A 3a51D-1yw1A:
undetectable
3a51D-1yw1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE


(Streptococcus
pyogenes)
PF00478
(IMPDH)
PF00571
(CBS)
5 ILE A  48
ASN A 282
ILE A 346
PRO A  47
LEU A 356
None
IMP  A 500 ( 4.5A)
None
None
None
1.17A 3a51D-1zfjA:
undetectable
3a51D-1zfjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE


(Pseudomonas
putida;
Spinacia
oleracea)
PF01070
(FMN_dh)
5 ILE A 345
LEU A 337
VAL A 304
PRO A  74
LEU A  75
None
1.09A 3a51D-2a7nA:
undetectable
3a51D-2a7nA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans)
PF00303
(Thymidylat_synt)
5 ILE A 228
LEU A 251
ILE A 250
PRO A  64
LEU A  58
None
1.10A 3a51D-2aazA:
undetectable
3a51D-2aazA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus)
PF00909
(Ammonium_transp)
5 ASN A  35
MET A  39
LEU A 104
VAL A 363
LEU A 369
None
1.24A 3a51D-2b2iA:
undetectable
3a51D-2b2iA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN


(Torpedo
marmorata)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
5 ILE E  55
LEU E  34
ILE E 208
VAL E  30
PRO E  87
None
1.22A 3a51D-2bg9E:
2.6
3a51D-2bg9E:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4)
PF09511
(RNA_lig_T4_1)
5 ILE A 217
LYS A 234
LEU A  79
ILE A  88
PRO A 214
None
1.13A 3a51D-2c5uA:
undetectable
3a51D-2c5uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE


(Pyrococcus
horikoshii)
PF00162
(PGK)
5 THR A  69
ILE A  87
THR A  13
VAL A 140
LEU A 137
None
1.00A 3a51D-2cunA:
undetectable
3a51D-2cunA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2


(Homo sapiens)
PF00179
(UQ_con)
5 ILE A  99
LEU A 103
ILE A 106
PRO A  65
LEU A  89
None
1.16A 3a51D-2espA:
undetectable
3a51D-2espA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2goj FE-SUPEROXIDE
DISMUTASE


(Plasmodium
falciparum)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
5 ILE A  96
MET A 195
ILE A 153
VAL A 182
PRO A  88
None
1.10A 3a51D-2gojA:
undetectable
3a51D-2gojA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2


(Arabidopsis
thaliana)
PF01704
(UDPGP)
5 ILE A 434
ASN A 383
ILE A 413
VAL A 424
LEU A 422
None
1.11A 3a51D-2icyA:
undetectable
3a51D-2icyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 THR A 570
ILE A 718
LEU A 762
ILE A 765
VAL A 345
None
1.25A 3a51D-2iujA:
undetectable
3a51D-2iujA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy4 NON-HEME
IRON-CONTAINING
FERRITIN


(Listeria
monocytogenes)
PF00210
(Ferritin)
5 MET A  46
ILE A  27
LYS A  93
MET A  95
VAL A  84
None
0.88A 3a51D-2iy4A:
undetectable
3a51D-2iy4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B


(Saccharomyces
cerevisiae)
PF16846
(Cep3)
5 MET A 174
ILE A 171
LEU A 179
ILE A 182
LEU A 106
None
1.02A 3a51D-2quqA:
2.1
3a51D-2quqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xbt CELLULOSOMAL
SCAFFOLDIN


(Pseudobacteroides
cellulosolvens)
PF00942
(CBM_3)
5 ILE A 113
LEU A  93
ILE A  45
VAL A 146
LEU A  12
None
0.95A 3a51D-2xbtA:
undetectable
3a51D-2xbtA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC


(Brugia malayi)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 THR A 428
LEU A 464
ILE A 472
VAL A 361
PRO A 384
None
1.13A 3a51D-2xgtA:
undetectable
3a51D-2xgtA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
6 MET A  74
ILE A  76
LEU A 226
ILE A 229
THR A 234
VAL A 277
PG4  A1399 ( 4.4A)
HEM  A1400 (-4.1A)
HEM  A1400 (-4.4A)
PG4  A1399 ( 4.5A)
HEM  A1400 (-3.7A)
HEM  A1400 (-4.5A)
0.64A 3a51D-2xkrA:
45.0
3a51D-2xkrA:
35.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT


(Methanosarcina
mazei)
PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7)
5 THR A  60
ILE A  51
THR A  38
VAL A  22
LEU A  18
None
1.21A 3a51D-2xr1A:
undetectable
3a51D-2xr1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbm PROTEIN-TYROSINE-PHO
SPHATASE


(Shewanella sp.)
PF00149
(Metallophos)
5 THR A  53
ILE A 187
ASN A 101
ILE A  59
LEU A 145
None
1.24A 3a51D-2zbmA:
undetectable
3a51D-2zbmA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus)
PF00067
(p450)
5 ILE A  96
ASN A 194
LEU A 240
ILE A 243
THR A 248
HEM  A 413 (-4.0A)
None
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.2A)
1.12A 3a51D-2zbzA:
47.7
3a51D-2zbzA:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER


(Escherichia
coli)
PF03797
(Autotransporter)
5 THR A1166
ILE A1096
THR A1311
VAL A1276
LEU A1255
None
0.95A 3a51D-3aehA:
undetectable
3a51D-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C


(Sulfurisphaera
tokodaii)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 THR C  75
ILE C  25
LEU C  18
ILE C  14
LEU C  34
None
1.10A 3a51D-3aizC:
undetectable
3a51D-3aizC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN


(Paracoccus
versutus)
PF06433
(Me-amine-dh_H)
5 THR H 359
ILE H 333
LEU H 355
ILE H 363
VAL H 377
None
1.15A 3a51D-3c75H:
undetectable
3a51D-3c75H:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR-SORTING
PROTEIN SNF8


(Homo sapiens)
PF04157
(EAP30)
5 ILE A 105
LEU A 151
ILE A 148
VAL A 128
LEU A 124
None
1.16A 3a51D-3cuqA:
undetectable
3a51D-3cuqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE


(Corynebacterium
diphtheriae)
PF12897
(Aminotran_MocR)
5 ILE A 348
LEU A 327
ILE A 326
PRO A 393
LEU A 401
None
1.21A 3a51D-3d6kA:
undetectable
3a51D-3d6kA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Cryptosporidium
parvum)
PF00069
(Pkinase)
5 ILE A 305
MET A 140
LEU A 301
VAL A 154
LEU A 150
None
1.22A 3a51D-3eb0A:
undetectable
3a51D-3eb0A:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME


(Bacillus
subtilis)
PF00067
(p450)
5 MET B  79
ASN B 181
LEU B 230
ILE B 233
THR B 238
None
None
HEM  B 405 ( 4.6A)
None
HEM  B 405 (-3.7A)
0.85A 3a51D-3ejbB:
47.6
3a51D-3ejbB:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)


(Sulfolobus
solfataricus)
PF07992
(Pyr_redox_2)
5 THR A 289
ILE A 121
MET A 275
ILE A 118
VAL A 104
None
NAP  A4005 (-3.8A)
None
None
None
1.13A 3a51D-3f8rA:
undetectable
3a51D-3f8rA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE


(Shewanella
oneidensis)
PF00756
(Esterase)
5 ILE A  80
ASN A 135
LEU A 124
VAL A 149
LEU A 140
None
1.17A 3a51D-3gffA:
undetectable
3a51D-3gffA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 ASN A 395
LEU A 146
THR A 189
VAL A 128
LEU A 129
None
1.14A 3a51D-3gg4A:
undetectable
3a51D-3gg4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR


(Chromobacterium
violaceum)
PF13377
(Peripla_BP_3)
5 THR A 133
MET A 155
ILE A 305
ASN A 107
ILE A  92
None
None
None
SO4  A   1 (-3.2A)
None
1.14A 3a51D-3h5oA:
undetectable
3a51D-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j23 CAPSID PROTEIN VP3

(Enterovirus A)
PF00073
(Rhv)
5 THR C 153
ILE C 133
LEU C 167
ILE C 169
VAL C  55
None
1.22A 3a51D-3j23C:
undetectable
3a51D-3j23C:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 CAPSID PROTEIN V20

(Mimivirus-dependent
virus Sputnik)
no annotation 5 ILE A 106
LEU A 238
ILE A 262
VAL A  71
LEU A 203
None
1.22A 3a51D-3j26A:
undetectable
3a51D-3j26A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Shewanella
oneidensis)
PF16113
(ECH_2)
5 MET A 190
ILE A 153
ASN A 173
MET A 175
VAL A 125
None
1.21A 3a51D-3ju1A:
undetectable
3a51D-3ju1A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p DSL1

(Kluyveromyces
lactis)
PF11989
(Dsl1_C)
5 THR C 633
ILE C 600
THR C 541
VAL C 522
LEU C 526
None
1.05A 3a51D-3k8pC:
undetectable
3a51D-3k8pC:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg6 PROTEASOME COMPONENT
C11


(Saccharomyces
cerevisiae)
PF00227
(Proteasome)
5 ILE J  59
LEU J  37
ILE J 101
VAL J  97
LEU J  87
None
1.23A 3a51D-3mg6J:
undetectable
3a51D-3mg6J:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nic ECO29KIR

(Escherichia
coli)
PF09517
(RE_Eco29kI)
5 ILE A 105
LEU A 101
ILE A 129
THR A  32
PRO A  39
None
1.19A 3a51D-3nicA:
undetectable
3a51D-3nicA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrv ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacterium
avium)
PF00378
(ECH_1)
5 ILE A  92
LEU A 114
THR A 151
VAL A 223
LEU A 227
None
1.13A 3a51D-3rrvA:
undetectable
3a51D-3rrvA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7b ENDO-1,4-BETA-XYLANA
SE


(Fusarium
oxysporum)
PF00331
(Glyco_hydro_10)
5 THR A 320
ILE A 269
LYS A  14
LEU A 246
LEU A 231
None
1.17A 3a51D-3u7bA:
undetectable
3a51D-3u7bA:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zby P450 HEME-THIOLATE
PROTEIN


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 ILE A  79
LEU A 229
ILE A 232
THR A 237
VAL A 280
HEM  A1402 (-4.2A)
HEM  A1402 ( 4.6A)
None
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
0.61A 3a51D-3zbyA:
42.8
3a51D-3zbyA:
36.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh2 L-LACTATE
DEHYDROGENASE


(Plasmodium
falciparum)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 244
ASN A 127
ILE A 123
VAL A  31
LEU A   9
None
1.21A 3a51D-3zh2A:
undetectable
3a51D-3zh2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
5 ILE A 112
ASN A 364
LEU A 236
ILE A 233
THR A 172
None
1.23A 3a51D-3zuqA:
undetectable
3a51D-3zuqA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2


(Homo sapiens)
PF00753
(Lactamase_B)
5 ILE A  93
ILE A  73
THR A  33
VAL A  18
LEU A  35
None
1.21A 3a51D-4ad9A:
undetectable
3a51D-4ad9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115


(Bacteroides
ovatus)
PF15979
(Glyco_hydro_115)
5 MET A 477
ILE A 473
LEU A 239
ILE A 236
LEU A 204
None
0.99A 3a51D-4c90A:
undetectable
3a51D-4c90A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN


(Chaetomium
thermophilum)
no annotation 5 LEU A 401
ILE A 407
THR A 369
VAL A 365
LEU A 445
None
1.18A 3a51D-4cyjA:
undetectable
3a51D-4cyjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Bacillus
subtilis)
PF02350
(Epimerase_2)
5 ASN A 158
THR A 282
VAL A 298
PRO A 292
LEU A 316
None
1.17A 3a51D-4fkzA:
undetectable
3a51D-4fkzA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxz SUPPRESSION OF
COPPER SENSITIVITY
PROTEIN


(Salmonella
enterica)
PF01323
(DSBA)
5 ILE A 119
LEU A 107
THR A  92
VAL A 131
LEU A 133
None
1.18A 3a51D-4gxzA:
undetectable
3a51D-4gxzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis)
PF15414
(DUF4621)
5 ILE A 121
LEU A 195
ILE A  99
VAL A 186
LEU A 221
None
1.20A 3a51D-4h3wA:
undetectable
3a51D-4h3wA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0c DEFORMYLASE

(Pseudomonas
putida)
PF12697
(Abhydrolase_6)
5 LEU A 195
ILE A 202
THR A 230
VAL A 206
PRO A 119
None
1.14A 3a51D-4l0cA:
undetectable
3a51D-4l0cA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN


(Homo sapiens)
PF00450
(Peptidase_S10)
5 LEU A 387
ILE A 419
VAL A 176
PRO A 157
LEU A 174
LEU  A 387 ( 0.6A)
ILE  A 419 ( 0.6A)
VAL  A 176 ( 0.6A)
PRO  A 157 ( 1.1A)
LEU  A 174 ( 0.5A)
1.09A 3a51D-4mwtA:
undetectable
3a51D-4mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omb PHOSPHATE BINDING
PROTEIN


(Pseudomonas
aeruginosa)
PF12849
(PBP_like_2)
5 THR A 139
ILE A 146
LEU A 165
ILE A 135
VAL A 218
None
1.19A 3a51D-4ombA:
undetectable
3a51D-4ombA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2


(Mus musculus)
PF00008
(EGF)
PF03098
(An_peroxidase)
5 ASN A  39
ILE A 499
THR A 483
VAL A 510
PRO A 506
None
1.10A 3a51D-4ph9A:
undetectable
3a51D-4ph9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plh MALATE DEHYDROGENASE

(Apicomplexa)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 241
ASN A 122
ILE A 118
VAL A  31
LEU A   9
None
OXM  A 401 ( 3.3A)
None
None
None
1.23A 3a51D-4plhA:
undetectable
3a51D-4plhA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens)
no annotation 5 THR C 218
ILE C 248
ASN C 185
ILE C 228
LEU C 269
None
0.75A 3a51D-4rwtC:
undetectable
3a51D-4rwtC:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkj D-LACTATE
DEHYDROGENASE


(Sporolactobacillus
inulinus)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 THR A  38
ILE A   4
ASN A  58
ILE A  50
VAL A 315
None
0.96A 3a51D-4xkjA:
undetectable
3a51D-4xkjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 ILE A 368
ILE A 373
VAL A 406
PRO A 402
LEU A 407
None
1.09A 3a51D-4xriA:
3.0
3a51D-4xriA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)


(Homo sapiens)
no annotation 5 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
None
None
GOL  A 505 (-4.2A)
None
None
0.84A 3a51D-4z79A:
undetectable
3a51D-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)


(Homo sapiens)
no annotation 5 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
None
None
NI  A 509 (-4.0A)
None
None
0.81A 3a51D-4z8gA:
undetectable
3a51D-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
5 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
None
0.86A 3a51D-4z94G:
undetectable
3a51D-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens)
PF00240
(ubiquitin)
5 THR A  85
ILE A  89
ILE A 112
VAL A 102
LEU A 119
None
1.18A 3a51D-5b83A:
undetectable
3a51D-5b83A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE


(Coccidioides
immitis)
PF00149
(Metallophos)
5 ILE A 216
LEU A 214
ILE A 208
VAL A 105
LEU A 132
None
1.24A 3a51D-5b8iA:
undetectable
3a51D-5b8iA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxu FERULIC ACID
ESTERASE AMCE1/FAE1A


(Anaeromyces
mucronatus)
PF00756
(Esterase)
5 MET A 134
ILE A 133
ILE A 165
PRO A  99
LEU A  62
None
1.24A 3a51D-5cxuA:
undetectable
3a51D-5cxuA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa)
PF01266
(DAO)
5 ILE A  16
LEU A 346
ILE A  52
VAL A  93
LEU A  90
FAD  A 401 (-4.8A)
FAD  A 401 (-4.3A)
None
None
None
1.07A 3a51D-5ez7A:
undetectable
3a51D-5ez7A:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1


(Homo sapiens)
PF03587
(EMG1)
5 ILE A 118
ASN A  65
LEU A 140
THR A 124
LEU A  92
None
UNX  A 304 ( 4.1A)
None
None
None
1.02A 3a51D-5faiA:
undetectable
3a51D-5faiA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE


(Desulfovibrio
alaskensis)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 ILE A 338
ILE A 317
VAL A 422
PRO A 430
LEU A 371
None
1.23A 3a51D-5favA:
2.9
3a51D-5favA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF


(Corynebacterium
ammoniagenes)
PF01687
(Flavokinase)
PF06574
(FAD_syn)
5 THR A 208
ILE A 252
ASN A 241
MET A 242
LEU A 318
None
1.17A 3a51D-5fo1A:
undetectable
3a51D-5fo1A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4q DNA POLYMERASE III
SUBUNIT BETA


(Helicobacter
pylori)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
5 THR A  91
MET A   1
ILE A   3
MET A 109
LEU A  10
None
1.10A 3a51D-5g4qA:
undetectable
3a51D-5g4qA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
5 ILE A  88
ASN A 181
MET A 184
LEU A 232
VAL A 283
HEM  A 501 ( 4.4A)
None
None
HEM  A 501 ( 4.7A)
HEM  A 501 (-4.7A)
1.00A 3a51D-5gnmA:
56.7
3a51D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
5 ILE A  88
MET A 184
LEU A 232
VAL A 283
PRO A 287
HEM  A 501 ( 4.4A)
None
HEM  A 501 ( 4.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
0.94A 3a51D-5gnmA:
56.7
3a51D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
7 MET A  86
ILE A  88
ASN A 181
LEU A 232
ILE A 235
THR A 240
VAL A 283
None
HEM  A 501 ( 4.4A)
None
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
1.28A 3a51D-5gnmA:
56.7
3a51D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
7 THR A  84
MET A  86
ILE A  88
ILE A 235
THR A 240
PRO A 287
LEU A 387
None
None
HEM  A 501 ( 4.4A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-3.5A)
None
0.90A 3a51D-5gnmA:
56.7
3a51D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
8 THR A  84
MET A  86
ILE A  88
LEU A 232
ILE A 235
THR A 240
VAL A 283
PRO A 287
None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
0.61A 3a51D-5gnmA:
56.7
3a51D-5gnmA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3c PROTEIN SUPPRESSOR
OF NPR1-1,
CONSTITUTIVE 1


(Arabidopsis
thaliana)
PF01582
(TIR)
5 ILE A  77
LEU A 174
ILE A 171
VAL A  32
LEU A  37
None
1.12A 3a51D-5h3cA:
undetectable
3a51D-5h3cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Francisella
tularensis)
PF00290
(Trp_syntA)
5 ASN A  69
ILE A  37
THR A 257
VAL A 260
PRO A  22
None
1.21A 3a51D-5kzmA:
undetectable
3a51D-5kzmA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l1t PENTALENOLACTONE
SYNTHASE


(Streptomyces
arenae)
PF00067
(p450)
5 ILE A  30
ASN A  64
ILE A 294
THR A  51
LEU A 309
None
1.20A 3a51D-5l1tA:
42.5
3a51D-5l1tA:
34.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l94 CYTOCHROME P450

(Bacillus
megaterium)
PF00067
(p450)
6 ILE A  85
LYS A 187
LEU A 238
ILE A 241
THR A 246
VAL A 289
HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.4A)
TES  A 502 (-4.8A)
0.45A 3a51D-5l94A:
49.7
3a51D-5l94A:
34.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-)
no annotation 5 THR A  70
ILE A 388
ASN A  73
ILE A 309
LEU A 552
None
1.21A 3a51D-5mz9A:
undetectable
3a51D-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 ILE A2534
MET A2461
LEU A2499
ILE A2498
THR A2522
None
1.12A 3a51D-5nugA:
undetectable
3a51D-5nugA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1)
PF00202
(Aminotran_3)
5 ILE A 434
LEU A 358
ILE A 423
VAL A  44
LEU A  55
None
1.14A 3a51D-5ti8A:
undetectable
3a51D-5ti8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium)
PF02310
(B12-binding)
5 ILE A 213
ASN A 137
LEU A 197
ILE A 196
LEU A 173
None
1.16A 3a51D-5ul4A:
2.5
3a51D-5ul4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 240
ASN A 121
ILE A 117
VAL A  30
LEU A   8
None
1.24A 3a51D-5ulvA:
undetectable
3a51D-5ulvA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)


(Lachnospiraceae
bacterium
NK4A179)
no annotation 5 ILE A 560
LYS A 530
ASN A 545
LEU A 592
LEU A 579
None
1.22A 3a51D-5wlhA:
1.1
3a51D-5wlhA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL


(Homo sapiens)
PF00384
(Molybdopterin)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
5 ILE M 418
ILE M 391
VAL M 475
PRO M 407
LEU M 516
None
1.10A 3a51D-5xtbM:
undetectable
3a51D-5xtbM:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE


(Saccharomyces
cerevisiae)
PF00201
(UDPGT)
PF03033
(Glyco_transf_28)
5 THR A 960
ILE A1148
ILE A1155
VAL A 770
LEU A 744
None
1.08A 3a51D-5xvmA:
undetectable
3a51D-5xvmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN


(Ruminiclostridium
thermocellum)
no annotation 5 LYS A 468
ASN A 464
ILE A 398
PRO A 497
LEU A 510
None
1.23A 3a51D-5yj6A:
undetectable
3a51D-5yj6A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei)
no annotation 5 ILE A 107
LEU A 252
ILE A 255
THR A 260
VAL A 303
HEM  A 501 (-4.2A)
HEM  A 501 ( 4.6A)
None
HEM  A 501 (-3.7A)
None
0.74A 3a51D-5ysmA:
39.3
3a51D-5ysmA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ep3 -

(-)
no annotation 5 ILE A  20
ASN A  65
LEU A  54
ILE A  51
LEU A  36
None
1.18A 3a51D-6ep3A:
undetectable
3a51D-6ep3A:
undetectable