SIMILAR PATTERNS OF AMINO ACIDS FOR 3A51_C_VDYC6178

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b44 PROTEIN (B-POL
SUBUNIT OF
HEAT-LABILE
ENTEROTOXIN)


(Escherichia
coli)
PF01376
(Enterotoxin_b)
PF11590
(DNAPolymera_Pol)
5 THR D  75
ILE D  40
LEU D  72
MET D 101
ILE D  20
None
1.09A 3a51C-1b44D:
0.0
3a51C-1b44D:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ


(Escherichia
virus G4)
PF02305
(Phage_F)
5 THR 1 406
MET 1 404
ILE 1  49
ASN 1 409
ILE 1  66
None
1.07A 3a51C-1gff1:
0.0
3a51C-1gff1:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io0 TROPOMODULIN

(Gallus gallus)
no annotation 5 THR A 234
ILE A 264
ASN A 201
VAL A 273
LEU A 285
None
1.04A 3a51C-1io0A:
0.0
3a51C-1io0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens)
PF00888
(Cullin)
PF10557
(Cullin_Nedd8)
5 THR A 166
ILE A 159
LEU A 162
VAL A  49
LEU A  88
None
1.17A 3a51C-1ldjA:
2.3
3a51C-1ldjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens)
PF00888
(Cullin)
5 THR A 166
ILE A 159
LEU A 162
VAL A  49
LEU A  88
None
1.10A 3a51C-1ldkA:
0.6
3a51C-1ldkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltd FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae)
PF00173
(Cyt-b5)
PF01070
(FMN_dh)
5 MET A 462
ILE A 458
LEU A 419
THR A 221
VAL A 223
None
1.15A 3a51C-1ltdA:
0.0
3a51C-1ltdA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mil SHC ADAPTOR PROTEIN

(Homo sapiens)
PF00017
(SH2)
5 ILE A  87
LEU A  94
ILE A  77
VAL A  63
LEU A  56
None
1.11A 3a51C-1milA:
undetectable
3a51C-1milA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE


(Xanthomonas
citri)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
5 MET A  54
ILE A  52
ASN A 186
VAL A 115
LEU A  77
None
None
GOL  A3011 (-4.1A)
None
None
1.06A 3a51C-1mpxA:
0.0
3a51C-1mpxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7f AMPA RECEPTOR
INTERACTING PROTEIN
GRIP


(Rattus
norvegicus)
PF00595
(PDZ)
5 ILE A 684
LEU A 701
ILE A 750
VAL A 746
LEU A 675
None
1.00A 3a51C-1n7fA:
undetectable
3a51C-1n7fA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT


(Klebsiella
pneumoniae)
PF03830
(PTSIIB_sorb)
5 MET A 108
ILE A   9
ILE A 154
VAL A 139
LEU A 134
None
1.16A 3a51C-1nrzA:
undetectable
3a51C-1nrzA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE


(Arabidopsis
thaliana)
PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1)
5 THR A  71
MET A  74
ILE A 187
LEU A  75
THR A 232
None
1.17A 3a51C-1u1hA:
undetectable
3a51C-1u1hA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ul1 FLAP ENDONUCLEASE-1

(Homo sapiens)
PF00752
(XPG_N)
PF00867
(XPG_I)
5 ILE X 212
LEU X 209
ILE X   3
VAL X 247
LEU X 226
None
1.14A 3a51C-1ul1X:
undetectable
3a51C-1ul1X:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR


(Bemisia tabaci)
PF00104
(Hormone_recep)
5 ILE U 315
LEU U 314
ILE U 482
THR U 480
LEU U 476
None
None
PO4  U   3 ( 4.8A)
None
None
1.17A 3a51C-1z5xU:
1.7
3a51C-1z5xU:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE


(Streptococcus
pyogenes)
PF00478
(IMPDH)
PF00571
(CBS)
5 ILE A  48
ASN A 282
ILE A 346
PRO A  47
LEU A 356
None
IMP  A 500 ( 4.5A)
None
None
None
1.17A 3a51C-1zfjA:
undetectable
3a51C-1zfjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9j GREEN FLUORESCENT
PROTEIN FP512


(Cerianthus
membranaceus)
PF01353
(GFP)
5 ILE A  75
ILE A 192
THR A 145
PRO A 187
LEU A 153
None
1.15A 3a51C-2c9jA:
undetectable
3a51C-2c9jA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE


(Pyrococcus
horikoshii)
PF00162
(PGK)
5 THR A  69
ILE A  87
THR A  13
VAL A 140
LEU A 137
None
0.99A 3a51C-2cunA:
undetectable
3a51C-2cunA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc4 165AA LONG
HYPOTHETICAL PROTEIN


(Pyrococcus
horikoshii)
PF01928
(CYTH)
5 ILE A  18
LEU A  21
ILE A 126
VAL A   9
LEU A 149
None
1.10A 3a51C-2dc4A:
undetectable
3a51C-2dc4A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy4 NON-HEME
IRON-CONTAINING
FERRITIN


(Listeria
monocytogenes)
PF00210
(Ferritin)
5 MET A  46
ILE A  27
LYS A  93
MET A  95
VAL A  84
None
1.05A 3a51C-2iy4A:
undetectable
3a51C-2iy4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA


(Homo sapiens)
PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8)
5 ILE B1109
LEU B1263
ILE B1060
VAL B1024
LEU B1021
None
1.05A 3a51C-2nvuB:
undetectable
3a51C-2nvuB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyx PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN,
RV1404


(Mycobacterium
tuberculosis)
PF01047
(MarR)
5 THR A  76
ILE A  53
LEU A  69
ILE A  89
VAL A 113
None
1.17A 3a51C-2nyxA:
undetectable
3a51C-2nyxA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4z METAL-DEPENDENT
HYDROLASES OF THE
BETA-LACTAMASE
SUPERFAMILY II


(Caldanaerobacter
subterraneus)
PF00753
(Lactamase_B)
5 THR A 161
ILE A 239
LEU A 228
VAL A 248
LEU A 222
None
1.20A 3a51C-2p4zA:
undetectable
3a51C-2p4zA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgg MICRONEME PROTEIN 2

(Toxoplasma
gondii)
PF00092
(VWA)
5 MET A 186
ILE A 184
LEU A 214
VAL A 113
LEU A 106
None
GOL  A1218 ( 4.7A)
None
None
None
0.94A 3a51C-2xggA:
undetectable
3a51C-2xggA:
17.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 MET A  74
ILE A  76
ILE A 229
THR A 234
VAL A 277
PG4  A1399 ( 4.4A)
HEM  A1400 (-4.1A)
PG4  A1399 ( 4.5A)
HEM  A1400 (-3.7A)
HEM  A1400 (-4.5A)
0.71A 3a51C-2xkrA:
45.1
3a51C-2xkrA:
35.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes)
PF00149
(Metallophos)
5 ILE A  98
LEU A 102
THR A 126
VAL A  88
LEU A  85
None
1.18A 3a51C-2xmoA:
1.0
3a51C-2xmoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT


(Methanosarcina
mazei)
PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7)
5 THR A  60
ILE A  51
THR A  38
VAL A  22
LEU A  18
None
1.19A 3a51C-2xr1A:
undetectable
3a51C-2xr1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Homo sapiens)
PF11921
(DUF3439)
PF13855
(LRR_8)
5 LEU B 129
ILE B 164
THR B 212
VAL B 210
LEU B 192
None
1.18A 3a51C-2z7xB:
undetectable
3a51C-2z7xB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl5 58 KD CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
5 ILE A 299
LEU A 301
ASN A 267
ILE A 330
THR A 341
None
1.14A 3a51C-2zl5A:
undetectable
3a51C-2zl5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvy CHEMOTAXIS PROTEIN
MOTB


(Salmonella
enterica)
PF00691
(OmpA)
5 ILE A 151
LEU A 140
MET A 161
ILE A 261
LEU A 226
None
1.20A 3a51C-2zvyA:
undetectable
3a51C-2zvyA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER


(Escherichia
coli)
PF03797
(Autotransporter)
5 THR A1166
ILE A1096
THR A1311
VAL A1276
LEU A1255
None
0.94A 3a51C-3aehA:
undetectable
3a51C-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B


(Sulfurisphaera
tokodaii)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 THR A  41
LEU A  40
ILE A 244
VAL A 130
PRO A 128
None
1.13A 3a51C-3aizA:
undetectable
3a51C-3aizA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjo UNCHARACTERIZED
ATP-BINDING PROTEIN
MJ1010


(Methanocaldococcus
jannaschii)
no annotation 5 ILE A  75
LEU A  76
ILE A  44
VAL A  99
LEU A 100
None
1.12A 3a51C-3bjoA:
undetectable
3a51C-3bjoA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION


(Escherichia
coli)
PF00041
(fn3)
PF13416
(SBP_bac_8)
5 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
None
1.00A 3a51C-3csgA:
undetectable
3a51C-3csgA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
5 THR A 821
ILE A 756
LEU A 758
ILE A 853
VAL A 798
None
1.06A 3a51C-3cttA:
undetectable
3a51C-3cttA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2

(Bos taurus)
PF00246
(Peptidase_M14)
5 ILE A 189
LEU A 183
ASN A 144
ILE A  64
VAL A 304
None
None
ACT  A 601 (-3.8A)
None
None
1.14A 3a51C-3d4uA:
undetectable
3a51C-3d4uA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR


(Chromobacterium
violaceum)
PF13377
(Peripla_BP_3)
5 THR A 133
MET A 155
ILE A 305
ASN A 107
ILE A  92
None
None
None
SO4  A   1 (-3.2A)
None
1.18A 3a51C-3h5oA:
undetectable
3a51C-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)


(Homo sapiens)
PF00702
(Hydrolase)
5 ILE A 280
LEU A 425
ASN A 396
THR A 449
LEU A 445
None
1.08A 3a51C-3hb0A:
undetectable
3a51C-3hb0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p DSL1

(Kluyveromyces
lactis)
PF11989
(Dsl1_C)
5 THR C 633
ILE C 600
THR C 541
VAL C 522
LEU C 526
None
1.02A 3a51C-3k8pC:
1.2
3a51C-3k8pC:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdq UNCHARACTERIZED
CONSERVED PROTEIN


(Corynebacterium
diphtheriae)
no annotation 5 THR A 117
MET A 118
ILE A 123
LEU A 100
LEU A  92
None
1.16A 3a51C-3kdqA:
2.1
3a51C-3kdqA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt9 APRATAXIN

(Homo sapiens)
PF00498
(FHA)
5 THR A  66
MET A  89
LEU A  87
ILE A  27
LEU A  19
None
1.19A 3a51C-3kt9A:
undetectable
3a51C-3kt9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR


(Escherichia
coli;
Homo sapiens)
PF02793
(HRM)
PF13416
(SBP_bac_8)
5 ILE A-236
LEU A -82
ILE A-285
VAL A-321
LEU A-324
None
1.07A 3a51C-3l2jA:
undetectable
3a51C-3l2jA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpx DNA GYRASE, A
SUBUNIT


(Colwellia
psychrerythraea)
PF00521
(DNA_topoisoIV)
5 THR A 324
MET A 277
ILE A 274
LEU A 273
ILE A 305
None
0.99A 3a51C-3lpxA:
1.7
3a51C-3lpxA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq9 BONE MARROW STROMAL
ANTIGEN 2 FUSED TO
MALTOSE-BINDING
PERIPLASMIC PROTEIN


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
PF16716
(BST2)
5 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
None
1.02A 3a51C-3mq9A:
undetectable
3a51C-3mq9A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzk PROTEIN TRANSPORT
PROTEIN SEC16


(Saccharomyces
cerevisiae)
PF12931
(Sec16_C)
PF12932
(Sec16)
5 THR B1080
ILE B1098
LEU B1084
VAL B1256
LEU B1260
None
0.86A 3a51C-3mzkB:
undetectable
3a51C-3mzkB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osl CARBOXYPEPTIDASE B2

(Bos taurus)
PF00246
(Peptidase_M14)
5 ILE A 303
LEU A 296
ASN A 256
ILE A 176
VAL A 419
None
1.14A 3a51C-3oslA:
undetectable
3a51C-3oslA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes)
PF01212
(Beta_elim_lyase)
5 ILE A 305
LEU A 358
ASN A 274
ILE A 317
LEU A 321
None
1.20A 3a51C-3pj0A:
undetectable
3a51C-3pj0A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sto SERINE PROTEASE
INHIBITOR


(Schistosoma
haematobium)
PF00079
(Serpin)
5 THR A  31
LEU A  27
ASN A 302
ILE A 382
PRO A 393
None
1.14A 3a51C-3stoA:
undetectable
3a51C-3stoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus)
PF00480
(ROK)
5 ILE A  76
LEU A  69
THR A  31
VAL A  39
LEU A  43
None
1.15A 3a51C-3vovA:
undetectable
3a51C-3vovA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1s AUTOPHAGY PROTEIN 5

(Saccharomyces
cerevisiae)
PF04106
(APG5)
5 ILE A  37
LEU A  35
THR A  43
VAL A  87
LEU A  45
None
1.00A 3a51C-3w1sA:
undetectable
3a51C-3w1sA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE


(Archaeoglobus
fulgidus;
Escherichia
coli)
PF13416
(SBP_bac_8)
5 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
None
1.06A 3a51C-3waiA:
undetectable
3a51C-3waiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger)
PF01979
(Amidohydro_1)
5 ILE A 404
LEU A 389
VAL A 102
PRO A 440
LEU A 436
None
1.07A 3a51C-4c60A:
undetectable
3a51C-4c60A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA


(Escherichia
coli)
PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2)
5 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
None
1.01A 3a51C-4dxbA:
undetectable
3a51C-4dxbA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1


(Saccharomyces
cerevisiae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ILE A 182
LEU A 181
THR A 435
VAL A 196
LEU A  98
None
1.17A 3a51C-4g1pA:
undetectable
3a51C-4g1pA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gou EHRGS-RHOGEF

(Entamoeba
histolytica)
PF00615
(RGS)
PF00621
(RhoGEF)
5 MET A 216
ILE A 221
LEU A 222
ASN A 281
ILE A 306
None
1.16A 3a51C-4gouA:
2.1
3a51C-4gouA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE


(Vitis vinifera)
PF00701
(DHDPS)
5 LEU A 257
MET A 234
ILE A 302
VAL A 313
LEU A 273
None
1.12A 3a51C-4hnnA:
undetectable
3a51C-4hnnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii3 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40


(Schizosaccharomyces
pombe)
PF00240
(ubiquitin)
5 THR B   9
ILE B  13
ILE B  36
VAL B  26
LEU B  43
None
1.13A 3a51C-4ii3B:
undetectable
3a51C-4ii3B:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8


(Escherichia
coli;
Homo sapiens)
PF00619
(CARD)
PF13416
(SBP_bac_8)
5 ILE A 109
LEU A 263
ILE A  60
VAL A  24
LEU A  21
None
1.07A 3a51C-4ikmA:
undetectable
3a51C-4ikmA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN


(Escherichia
coli;
Homo sapiens)
PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8)
5 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
None
None
None
BOG  A1301 ( 4.1A)
None
1.01A 3a51C-4kegA:
undetectable
3a51C-4kegA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1g PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Bacillus cereus)
PF01522
(Polysacc_deac_1)
5 LEU A 107
ILE A 150
VAL A 141
PRO A 136
LEU A 138
None
None
None
PXU  A 171 ( 4.9A)
None
1.01A 3a51C-4l1gA:
undetectable
3a51C-4l1gA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4w ESPG3

(Mycolicibacterium
smegmatis)
PF14011
(ESX-1_EspG)
5 ILE A  72
LEU A  20
ASN A  59
VAL A 115
LEU A   8
None
1.07A 3a51C-4l4wA:
undetectable
3a51C-4l4wA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT


(Escherichia
coli;
Homo sapiens)
PF00104
(Hormone_recep)
PF13416
(SBP_bac_8)
5 ILE A 110
LEU A 264
ILE A  61
VAL A  25
LEU A  22
None
0.93A 3a51C-4logA:
1.9
3a51C-4logA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT


(Escherichia
coli;
Plasmodium
falciparum)
PF02617
(ClpS)
PF13416
(SBP_bac_8)
5 ILE A 109
LEU A 263
ILE A  60
VAL A  24
LEU A  21
None
1.04A 3a51C-4o2xA:
undetectable
3a51C-4o2xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofs PROBABLE LIPOAMIDE
ACYLTRANSFERASE


(Thermoplasma
acidophilum)
PF00198
(2-oxoacid_dh)
5 MET A  43
ILE A  46
LEU A  47
ASN A 152
ILE A  66
None
1.13A 3a51C-4ofsA:
undetectable
3a51C-4ofsA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2


(Mus musculus)
PF00008
(EGF)
PF03098
(An_peroxidase)
5 ASN A  39
ILE A 499
THR A 483
VAL A 510
PRO A 506
None
1.11A 3a51C-4ph9A:
undetectable
3a51C-4ph9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1


(Escherichia
coli;
Rattus
norvegicus)
PF03359
(GKAP)
PF13416
(SBP_bac_8)
5 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
None
1.01A 3a51C-4r0yA:
undetectable
3a51C-4r0yA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens)
no annotation 5 THR C 218
ILE C 248
ASN C 185
ILE C 228
LEU C 269
None
0.86A 3a51C-4rwtC:
undetectable
3a51C-4rwtC:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN


(Escherichia
coli;
Homo sapiens)
PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8)
5 ILE A 132
LEU A 286
ILE A  83
VAL A  47
LEU A  44
None
1.02A 3a51C-4wrnA:
undetectable
3a51C-4wrnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE


(Providencia
alcalifaciens)
PF00551
(Formyl_trans_N)
PF12796
(Ank_2)
5 ILE A   5
LEU A  28
ILE A  70
VAL A 163
LEU A 167
None
1.11A 3a51C-4xd0A:
undetectable
3a51C-4xd0A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkj D-LACTATE
DEHYDROGENASE


(Sporolactobacillus
inulinus)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 THR A  38
ILE A   4
ASN A  58
ILE A  50
VAL A 315
None
1.02A 3a51C-4xkjA:
undetectable
3a51C-4xkjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 ILE A 368
ILE A 373
VAL A 406
PRO A 402
LEU A 407
None
1.08A 3a51C-4xriA:
undetectable
3a51C-4xriA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)


(Homo sapiens)
no annotation 5 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
None
None
GOL  A 505 (-4.2A)
None
None
0.81A 3a51C-4z79A:
undetectable
3a51C-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)


(Homo sapiens)
no annotation 5 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
None
None
NI  A 509 (-4.0A)
None
None
0.79A 3a51C-4z8gA:
undetectable
3a51C-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
5 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
None
0.84A 3a51C-4z94G:
undetectable
3a51C-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5auo ATPASE INVOLVED IN
CHROMOSOME
PARTITIONING,
PARA/MIND FAMILY,
MRP HOMOLOG


(Thermococcus
kodakarensis)
PF10609
(ParA)
5 MET B 133
ILE B 131
LEU B  56
VAL B  18
LEU B  15
None
1.09A 3a51C-5auoB:
undetectable
3a51C-5auoB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3


(Homo sapiens)
PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3)
5 THR A 416
ILE A 702
THR A 590
VAL A 856
PRO A 683
None
1.06A 3a51C-5b16A:
undetectable
3a51C-5b16A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens)
PF00240
(ubiquitin)
5 THR A  85
ILE A  89
ILE A 112
VAL A 102
LEU A 119
None
1.17A 3a51C-5b83A:
undetectable
3a51C-5b83A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19


(Escherichia
coli;
Tetrahymena
thermophila)
PF13416
(SBP_bac_8)
5 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
None
1.06A 3a51C-5dfmA:
undetectable
3a51C-5dfmA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
5 ILE D 108
LEU D 262
ILE D  59
VAL D  23
LEU D  20
None
1.11A 3a51C-5disD:
undetectable
3a51C-5disD:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2


(Rickettsia
typhi)
PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31)
5 THR A 353
MET A 358
ILE A 361
LEU A 362
LEU A 411
None
1.12A 3a51C-5dooA:
undetectable
3a51C-5dooA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48


(Mycolicibacterium
smegmatis)
PF00004
(AAA)
PF02359
(CDC48_N)
5 ILE A 325
LEU A 323
ILE A 348
VAL A 373
LEU A 377
None
1.20A 3a51C-5e7pA:
undetectable
3a51C-5e7pA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A


(Brevibacillus
parabrevis)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C)
5 MET A 654
ILE A 600
LEU A 650
PRO A 602
LEU A 581
None
1.19A 3a51C-5es9A:
undetectable
3a51C-5es9A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN


(Hantaan
orthohantavirus)
PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8)
5 ILE A-264
LEU A-110
ILE A-313
VAL A-349
LEU A-352
None
0.98A 3a51C-5fsgA:
undetectable
3a51C-5fsgA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
7 ILE A  88
LEU A  89
ILE A 235
THR A 240
VAL A 283
PRO A 287
LEU A 387
HEM  A 501 ( 4.4A)
None
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
None
0.81A 3a51C-5gnmA:
56.6
3a51C-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
8 THR A  84
MET A  86
ILE A  88
LEU A  89
ILE A 235
THR A 240
VAL A 283
PRO A 287
None
None
HEM  A 501 ( 4.4A)
None
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
0.59A 3a51C-5gnmA:
56.6
3a51C-5gnmA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD


(Danio rerio;
Escherichia
coli)
PF02758
(PYRIN)
PF13416
(SBP_bac_8)
5 ILE A 109
LEU A 263
ILE A  60
VAL A  24
LEU A  21
None
1.08A 3a51C-5gppA:
undetectable
3a51C-5gppA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG


(Escherichia
coli;
Serratia)
PF13416
(SBP_bac_8)
5 ILE A 110
LEU A 264
ILE A  61
VAL A  25
LEU A  22
None
0.99A 3a51C-5gxvA:
undetectable
3a51C-5gxvA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E


(Castellaniella
defragrans)
no annotation 5 THR A 202
ILE A 209
LEU A 206
THR A 240
LEU A 245
None
1.16A 3a51C-5hssA:
undetectable
3a51C-5hssA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR


(Escherichia
coli;
Haliotis
rufescens)
PF11386
(VERL)
PF13416
(SBP_bac_8)
5 ILE A3775
LEU A3929
ILE A3726
VAL A3690
LEU A3687
None
1.05A 3a51C-5ii5A:
undetectable
3a51C-5ii5A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA


(Escherichia
coli)
PF01335
(DED)
PF13416
(SBP_bac_8)
5 ILE A 120
LEU A 274
ILE A  71
VAL A  35
LEU A  32
None
1.06A 3a51C-5jqeA:
undetectable
3a51C-5jqeA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN


(Escherichia
coli)
PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8)
5 ILE A 108
LEU A1262
ILE A  59
VAL A  23
LEU A  20
None
1.03A 3a51C-5k94A:
undetectable
3a51C-5k94A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Francisella
tularensis)
PF00290
(Trp_syntA)
5 ASN A  69
ILE A  37
THR A 257
VAL A 260
PRO A  22
None
1.18A 3a51C-5kzmA:
undetectable
3a51C-5kzmA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l94 CYTOCHROME P450

(Bacillus
megaterium)
PF00067
(p450)
5 ILE A  85
LYS A 187
ILE A 241
THR A 246
VAL A 289
HEM  A 501 (-4.4A)
None
TES  A 502 (-4.0A)
HEM  A 501 (-3.4A)
TES  A 502 (-4.8A)
0.36A 3a51C-5l94A:
49.9
3a51C-5l94A:
34.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION


(Lactobacillus
reuteri)
no annotation 5 ILE A 294
LEU A 290
ILE A 282
VAL A 331
LEU A 333
None
1.12A 3a51C-5ny0A:
undetectable
3a51C-5ny0A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6y PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Bacillus cereus)
no annotation 5 LEU B 107
ILE B 150
VAL B 141
PRO B 136
LEU B 138
None
None
None
NA  B 311 ( 4.6A)
PXU  B 171 ( 4.9A)
1.04A 3a51C-5o6yB:
undetectable
3a51C-5o6yB:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA


(Acinetobacter
baumannii;
Escherichia
coli)
no annotation 5 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
None
SER  A1205 (-3.9A)
None
None
None
0.97A 3a51C-5vawA:
undetectable
3a51C-5vawA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE


(Escherichia
coli;
Serratia
marcescens)
no annotation 5 ILE A 110
LEU A 264
ILE A  61
VAL A  25
LEU A  22
None
1.03A 3a51C-5wvmA:
2.7
3a51C-5wvmA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxv ISOCHORISMATE LYASE

(Vibrio
anguillarum)
no annotation 5 THR A  79
ILE A 147
LEU A  36
LYS A 129
VAL A 196
None
1.16A 3a51C-5wxvA:
undetectable
3a51C-5wxvA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL


(Homo sapiens)
PF00384
(Molybdopterin)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
5 ILE M 418
ILE M 391
VAL M 475
PRO M 407
LEU M 516
None
1.12A 3a51C-5xtbM:
undetectable
3a51C-5xtbM:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE


(Saccharomyces
cerevisiae)
PF00201
(UDPGT)
PF03033
(Glyco_transf_28)
5 THR A 960
ILE A1148
ILE A1155
VAL A 770
LEU A 744
None
1.11A 3a51C-5xvmA:
undetectable
3a51C-5xvmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1


(Escherichia
coli;
Homo sapiens)
no annotation 5 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
None
1.08A 3a51C-6apxA:
undetectable
3a51C-6apxA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c33 5'-3' EXONUCLEASE

(Mycolicibacterium
smegmatis)
no annotation 5 ILE A 114
LEU A  55
MET A  13
ILE A 105
VAL A 294
None
1.18A 3a51C-6c33A:
undetectable
3a51C-6c33A:
10.67