SIMILAR PATTERNS OF AMINO ACIDS FOR 3A51_B_VDYB6178

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 PRO A 604
LEU A 605
ILE A 402
VAL A 387
LEU A 362
 None
 1.35A 3a51B-1br2A:
1.8		 3a51B-1br2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmo POLYOMAVIRUS
ENHANCER BINDING
PROTEIN 2

(Homo sapiens) 		PF00853
(Runt) 		5 ASN A 119
ILE A 150
THR A  65
VAL A  63
PRO A  76
 None
 1.44A 3a51B-1cmoA:
undetectable		 3a51B-1cmoA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb) 		5 PRO A 120
THR A 101
LEU A  58
ILE A  72
LEU A 185
 FAD  A 600 ( 4.5A)
FAD  A 600 ( 4.2A)
None
None
None
 1.29A 3a51B-1f0xA:
0.0		 3a51B-1f0xA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hq0 CYTOTOXIC
NECROTIZING FACTOR 1

(Escherichia
coli) 		PF05785
(CNF1) 		5 PRO A 855
THR A 828
LEU A 732
ILE A 746
THR A 974
 None
 1.39A 3a51B-1hq0A:
0.0		 3a51B-1hq0A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 PRO A 330
LEU A 311
ASN A 293
VAL A 181
LEU A 197
 None
 1.12A 3a51B-1j3uA:
0.9		 3a51B-1j3uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 ASN A  51
THR A 495
VAL A 520
PRO A 524
LEU A 500
 None
GOL  A1820 ( 4.7A)
None
None
TRO  A 512 ( 4.2A)
 1.36A 3a51B-1kb0A:
0.0		 3a51B-1kb0A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 THR A 527
LEU A 528
ASN A 382
VAL A  96
LEU A 125
 None
None
PQQ  A 801 (-3.2A)
None
None
 1.25A 3a51B-1kv9A:
0.0		 3a51B-1kv9A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1

(Caenorhabditis
elegans) 		PF00248
(Aldo_ket_red) 		5 THR A  23
LEU A  21
ILE A  78
VAL A  71
LEU A  65
 None
 1.25A 3a51B-1qwkA:
0.0		 3a51B-1qwkA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 PRO A 295
ILE A  61
THR A  31
VAL A  26
PRO A  75
 None
 1.23A 3a51B-1rxwA:
0.0		 3a51B-1rxwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svi GTP-BINDING PROTEIN
YSXC

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		5 PRO A  24
LYS A 190
ASN A 194
ILE A 138
LEU A  43
 None
 1.33A 3a51B-1sviA:
undetectable		 3a51B-1sviA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqj RIBULOSE-PHOSPHATE
3-EPIMERASE

(Synechocystis
sp.) 		PF00834
(Ribul_P_3_epim) 		5 THR A 123
LEU A 119
ASN A  96
VAL A 134
LEU A 105
 None
 1.37A 3a51B-1tqjA:
undetectable		 3a51B-1tqjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		5 ASN A 486
ILE A 466
THR A 428
VAL A 457
LEU A 454
 None
 1.31A 3a51B-1wkyA:
undetectable		 3a51B-1wkyA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		5 PRO A 134
LEU A 102
ASN A 185
THR A   7
LEU A  32
 None
 1.46A 3a51B-1ztvA:
undetectable		 3a51B-1ztvA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 MET B   1
LEU B 158
ASN B 163
VAL B  12
LEU B 177
 None
 1.22A 3a51B-2amcB:
undetectable		 3a51B-2amcB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 PRO B 666
LEU B 560
THR B 512
VAL B 510
LEU B 570
 None
 1.38A 3a51B-2amcB:
undetectable		 3a51B-2amcB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		5 PRO A 215
THR A 216
ASN A 211
ILE A 359
LEU A 198
 None
None
NAP  A1367 (-3.0A)
None
None
 1.43A 3a51B-2cdaA:
undetectable		 3a51B-2cdaA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10

(Homo sapiens) 		PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin) 		5 THR A 164
ILE A 149
VAL A 262
PRO A 264
LEU A 250
 None
 1.41A 3a51B-2d7iA:
undetectable		 3a51B-2d7iA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 PRO A  38
THR A  37
ASN A 188
VAL A  25
LEU A  27
 None
FAD  A1002 (-3.4A)
FAD  A1002 (-3.7A)
None
None
 1.41A 3a51B-2e5vA:
undetectable		 3a51B-2e5vA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eja UROPORPHYRINOGEN
DECARBOXYLASE

(Aquifex
aeolicus) 		PF01208
(URO-D) 		5 ASN A 205
ILE A  76
VAL A  87
PRO A  95
LEU A  97
 None
 1.44A 3a51B-2ejaA:
undetectable		 3a51B-2ejaA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fia ACETYLTRANSFERASE

(Enterococcus
faecalis) 		PF00583
(Acetyltransf_1) 		5 PRO A  38
LEU A  18
ILE A  47
VAL A  56
LEU A  54
 None
 1.42A 3a51B-2fiaA:
undetectable		 3a51B-2fiaA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 THR A  85
LEU A  87
THR A  24
VAL A  28
LEU A  39
 None
 1.40A 3a51B-2hnhA:
3.3		 3a51B-2hnhA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nm0 PROBABLE
3-OXACYL-(ACYL-CARRI
ER-PROTEIN)
REDUCTASE

(Streptomyces
coelicolor) 		PF13561
(adh_short_C2) 		5 THR A 207
LEU A 211
ILE A 125
THR A 103
VAL A 107
 None
 1.31A 3a51B-2nm0A:
undetectable		 3a51B-2nm0A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG

(Aquifex
aeolicus) 		PF00994
(MoCF_biosynth) 		5 LEU A 134
ILE A 152
THR A 166
VAL A  37
LEU A  34
 None
 1.32A 3a51B-2qq1A:
undetectable		 3a51B-2qq1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy1 PECTATE LYASE II

(Xanthomonas
campestris) 		PF00544
(Pec_lyase_C) 		5 THR A 217
ASN A 212
MET A 180
ILE A 178
VAL A 227
 None
 1.42A 3a51B-2qy1A:
undetectable		 3a51B-2qy1A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5v PCZA361.1

(Amycolatopsis
orientalis) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		5 MET A  11
LEU A  54
ILE A 242
THR A 308
VAL A 261
 None
 1.39A 3a51B-2r5vA:
undetectable		 3a51B-2r5vA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli) 		PF00154
(RecA) 		5 PRO A  57
LEU A 188
ASN A 249
ILE A  64
THR A  73
 None
 1.43A 3a51B-2rebA:
undetectable		 3a51B-2rebA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vve SPIKE PROTEIN P1

(Pseudoalteromonas
virus PM2) 		no annotation 5 ASN A  94
MET A 332
ILE A 119
VAL A 163
LEU A 100
 None
 1.41A 3a51B-2vveA:
undetectable		 3a51B-2vveA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 PRO A 386
THR A 385
LEU A 378
THR A 322
VAL A  10
 None
 1.33A 3a51B-2w8sA:
undetectable		 3a51B-2w8sA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus) 		PF00258
(Flavodoxin_1) 		5 PRO A  64
LEU A  63
ASN A  36
VAL A 125
LEU A  94
 None
 1.35A 3a51B-2wc1A:
undetectable		 3a51B-2wc1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8x TLR1789 PROTEIN

(Thermosynechococcus
elongatus) 		PF07244
(POTRA)
PF08479
(POTRA_2) 		5 PRO X 143
LEU X 173
VAL X 199
PRO X 203
LEU X 213
 None
 1.39A 3a51B-2x8xX:
undetectable		 3a51B-2x8xX:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8f RAN-BINDING PROTEIN
3

(Homo sapiens) 		PF00638
(Ran_BP1) 		5 THR A 389
LEU A 391
ILE A 422
THR A 429
LEU A 334
 None
 1.33A 3a51B-2y8fA:
undetectable		 3a51B-2y8fA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 PRO A 440
LEU A 408
ASN A 435
ILE A 327
LEU A 424
 None
 1.38A 3a51B-2y8nA:
0.8		 3a51B-2y8nA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		5 MET A 204
ILE A 278
THR A 262
VAL A 236
LEU A 215
 None
 1.35A 3a51B-2ykfA:
undetectable		 3a51B-2ykfA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		5 MET A 204
LEU A 222
ILE A 278
VAL A 236
LEU A 215
 None
 1.33A 3a51B-2ykfA:
undetectable		 3a51B-2ykfA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		6 PRO B 130
LEU B 129
ILE B 164
THR B 212
VAL B 210
LEU B 192
 None
 1.34A 3a51B-2z7xB:
undetectable		 3a51B-2z7xB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER

(Escherichia
coli) 		PF03797
(Autotransporter) 		5 THR A1166
ILE A1096
THR A1311
VAL A1276
LEU A1255
 None
 0.94A 3a51B-3aehA:
undetectable		 3a51B-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 THR A  41
LEU A  40
ILE A 244
VAL A 130
PRO A 128
 None
 1.19A 3a51B-3aizA:
undetectable		 3a51B-3aizA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al9 PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 THR A 232
LEU A 233
ILE A 241
THR A 167
VAL A 162
 None
 1.12A 3a51B-3al9A:
undetectable		 3a51B-3al9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PRO A1057
LEU A1188
ASN A1249
ILE A1064
THR A1073
 None
None
None
None
MG  A1701 ( 3.0A)
 1.46A 3a51B-3cmvA:
undetectable		 3a51B-3cmvA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PRO A2057
LEU A2188
ASN A2249
ILE A2064
THR A2073
 None
None
None
None
MG  A2701 ( 3.0A)
 1.46A 3a51B-3cmvA:
undetectable		 3a51B-3cmvA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 PRO A 320
LEU A 319
ILE A 572
THR A 579
LEU A 619
 None
 1.26A 3a51B-3cttA:
undetectable		 3a51B-3cttA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efx CHOLERA ENTEROTOXIN
SUBUNIT B,
HEAT-LABILE
ENTEROTOXIN B CHAIN

(Escherichia
coli;
Vibrio cholerae) 		PF01376
(Enterotoxin_b) 		5 THR D  71
MET D  68
MET D 101
THR D  15
LEU D   8
 None
 1.42A 3a51B-3efxD:
undetectable		 3a51B-3efxD:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it7 PROTEASE LASA

(Pseudomonas
aeruginosa) 		PF01551
(Peptidase_M23) 		5 ASN A 177
ILE A 144
VAL A 132
PRO A   2
LEU A 125
 None
 1.39A 3a51B-3it7A:
undetectable		 3a51B-3it7A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV

(Corynebacterium
glutamicum) 		PF00465
(Fe-ADH) 		5 PRO A 354
LEU A 357
THR A 324
VAL A 328
LEU A 239
 None
 1.31A 3a51B-3iv7A:
undetectable		 3a51B-3iv7A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1u CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1, SERYL
T-RNA SYNTHETASE
CHIMERA

(Mus musculus) 		PF12777
(MT) 		5 PRO A3347
THR A3348
ILE A3339
VAL A3305
LEU A3302
 None
 1.41A 3a51B-3j1uA:
undetectable		 3a51B-3j1uA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ka7 OXIDOREDUCTASE

(Methanosarcina
mazei) 		PF01593
(Amino_oxidase) 		5 PRO A 191
LEU A  57
ASN A  41
VAL A 416
LEU A  14
 None
 1.25A 3a51B-3ka7A:
undetectable		 3a51B-3ka7A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		5 THR A 143
LEU A  39
ILE A  28
THR A  68
LEU A  70
 None
 1.41A 3a51B-3l8qA:
undetectable		 3a51B-3l8qA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oce FUMARATE LYASE:DELTA
CRYSTALLIN

(Brucella
abortus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 PRO A 329
LEU A 310
ASN A 292
VAL A 180
LEU A 196
 None
 1.20A 3a51B-3oceA:
undetectable		 3a51B-3oceA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7n SENSOR HISTIDINE
KINASE

(Erythrobacter
litoralis) 		PF00196
(GerE)
PF13426
(PAS_9) 		5 LEU A 102
ASN A 107
ILE A  38
THR A 209
LEU A 135
 None
FMN  A 500 (-3.1A)
None
None
None
 1.30A 3a51B-3p7nA:
undetectable		 3a51B-3p7nA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsq CAPSID POLYPROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		5 LEU A 590
ASN A 445
MET A 442
VAL A 434
LEU A 436
 None
 1.31A 3a51B-3qsqA:
undetectable		 3a51B-3qsqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6y ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1) 		5 PRO A 330
LEU A 311
ASN A 293
VAL A 181
LEU A 197
 PRO  A 330 ( 1.1A)
LEU  A 311 ( 0.6A)
ASN  A 293 ( 0.6A)
VAL  A 181 ( 0.6A)
LEU  A 197 ( 0.5A)
 1.11A 3a51B-3r6yA:
undetectable		 3a51B-3r6yA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 PRO A 497
LEU A 540
ILE A 535
VAL A 586
LEU A 600
 None
 1.26A 3a51B-3r75A:
undetectable		 3a51B-3r75A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsc PUTATIVE
OXIDOREDUCTASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 THR A 247
LEU A 251
ILE A 155
THR A 132
VAL A 136
 None
None
NAD  A 274 (-4.6A)
None
None
 1.27A 3a51B-3tscA:
undetectable		 3a51B-3tscA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyu ANTIFREEZE PROTEIN

(Leucosporidium
sp. AY30) 		PF11999
(DUF3494) 		5 PRO A  97
THR A  96
LEU A 100
ILE A  87
VAL A 233
 None
 1.26A 3a51B-3uyuA:
undetectable		 3a51B-3uyuA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		5 THR A 446
LEU A 429
ILE A 373
VAL A 383
LEU A 349
 None
 1.45A 3a51B-3wo8A:
undetectable		 3a51B-3wo8A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13855
(LRR_8) 		5 LEU A 214
ASN A 241
ILE A 175
THR A 153
LEU A 167
 None
 1.45A 3a51B-3zyoA:
undetectable		 3a51B-3zyoA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k CULLIN-4A

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		5 MET A 704
LEU A 710
ASN A 751
ILE A 736
VAL A 727
 None
 1.35A 3a51B-4a0kA:
2.3		 3a51B-4a0kA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 LEU A 232
ASN A 573
ILE A 565
THR A 212
LEU A 248
 None
 1.37A 3a51B-4cj0A:
undetectable		 3a51B-4cj0A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1

(Methanocaldococcus
jannaschii) 		PF00999
(Na_H_Exchanger) 		5 LEU A 256
ILE A 195
VAL A 166
PRO A 162
LEU A 163
 None
 1.39A 3a51B-4czbA:
undetectable		 3a51B-4czbA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3

(Homo sapiens) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		5 THR A 699
ASN A 769
ILE A 678
VAL A 626
LEU A 623
 None
 1.44A 3a51B-4dloA:
undetectable		 3a51B-4dloA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2) 		5 PRO E 457
THR E 462
LEU E 456
ILE E 568
VAL E 575
 None
 1.36A 3a51B-4f52E:
2.8		 3a51B-4f52E:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2) 		5 PRO E 457
THR E 462
LEU E 456
VAL E 575
LEU E 475
 None
 1.40A 3a51B-4f52E:
2.8		 3a51B-4f52E:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe1 PHOTOSYSTEM I
IRON-SULFUR CENTER

(Thermosynechococcus
elongatus) 		PF12838
(Fer4_7) 		5 PRO C  58
THR C  59
ILE C   6
VAL C  24
LEU C  25
 SF4  C 102 ( 4.9A)
SF4  C 102 ( 4.4A)
None
SF4  C 101 (-4.3A)
SF4  C 101 ( 4.9A)
 1.23A 3a51B-4fe1C:
undetectable		 3a51B-4fe1C:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		5 LEU A  55
ILE A 192
THR A 133
VAL A 113
LEU A  64
 None
 1.30A 3a51B-4hdtA:
undetectable		 3a51B-4hdtA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PRO A   8
ILE A  86
VAL A 356
PRO A 358
LEU A 335
 None
 1.21A 3a51B-4j6fA:
undetectable		 3a51B-4j6fA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1g PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE

(Bacillus cereus) 		PF01522
(Polysacc_deac_1) 		5 LEU A 107
ILE A 150
VAL A 141
PRO A 136
LEU A 138
 None
None
None
PXU  A 171 ( 4.9A)
None
 1.05A 3a51B-4l1gA:
undetectable		 3a51B-4l1gA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le6 ORGANOPHOSPHORUS
HYDROLASE

(Pseudomonas
pseudoalcaligenes) 		PF00753
(Lactamase_B) 		5 THR A  96
ILE A 103
THR A 105
VAL A 118
LEU A  50
 None
None
None
GOL  A 401 (-3.8A)
None
 1.26A 3a51B-4le6A:
undetectable		 3a51B-4le6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		5 PRO A 137
ASN A 124
THR A 108
PRO A 504
LEU A 111
 None
 1.32A 3a51B-4mhcA:
undetectable		 3a51B-4mhcA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E

(Butyrivibrio
proteoclasticus) 		PF04616
(Glyco_hydro_43) 		5 PRO A  25
THR A  38
ILE A  20
PRO A  15
LEU A 277
 None
 1.38A 3a51B-4novA:
undetectable		 3a51B-4novA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu3 ICE-BINDING PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		5 PRO A 109
THR A 108
LEU A 112
ILE A  99
VAL A 245
 None
 1.29A 3a51B-4nu3A:
undetectable		 3a51B-4nu3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o87 N-TAGGED NUCLEASE

(Millerozyma
acaciae) 		no annotation 5 THR A 294
LEU A 290
ILE A  12
VAL A  50
LEU A 124
 None
None
None
None
SO4  A 502 (-3.8A)
 1.38A 3a51B-4o87A:
1.2		 3a51B-4o87A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		5 PRO A 231
ASN A 312
ILE A 131
VAL A 154
LEU A 140
 None
 1.30A 3a51B-4p6bA:
undetectable		 3a51B-4p6bA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 ASN A  39
ILE A 499
THR A 483
VAL A 510
PRO A 506
 None
 1.08A 3a51B-4ph9A:
2.0		 3a51B-4ph9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pju COHESIN SUBUNIT SA-2

(Homo sapiens) 		PF08514
(STAG) 		5 LEU A 776
ILE A 829
THR A 881
VAL A 877
LEU A 871
 None
 1.26A 3a51B-4pjuA:
2.4		 3a51B-4pjuA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7k ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 LEU A 540
ILE A 492
THR A 520
VAL A 356
LEU A 382
 None
 1.43A 3a51B-4q7kA:
undetectable		 3a51B-4q7kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 PRO A 100
THR A 101
ASN A 242
ILE A 127
PRO A  91
 None
None
None
FDA  A 501 (-4.4A)
None
 1.23A 3a51B-4x28A:
undetectable		 3a51B-4x28A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNH

(Escherichia
coli) 		PF05845
(PhnH) 		5 THR B 189
LEU B 138
VAL B 127
PRO B 151
LEU B 153
 None
None
CME  B 178 ( 4.2A)
None
None
 1.27A 3a51B-4xb6B:
undetectable		 3a51B-4xb6B:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yys FICIN ISOFORM B

(Ficus carica) 		PF00112
(Peptidase_C1) 		5 PRO A 132
ILE A 110
VAL A 107
PRO A  46
LEU A  48
 None
 1.14A 3a51B-4yysA:
undetectable		 3a51B-4yysA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyw FICIN ISOFORM D

(Ficus carica) 		PF00112
(Peptidase_C1) 		5 PRO A 132
ILE A 110
VAL A 107
PRO A  46
LEU A  48
 None
 1.19A 3a51B-4yywA:
undetectable		 3a51B-4yywA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Trichophyton
rubrum) 		no annotation 5 ASN D 261
ILE D 332
VAL D 319
PRO D 162
LEU D 274
 None
 1.33A 3a51B-4zhsD:
undetectable		 3a51B-4zhsD:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrx F5/8 TYPE C DOMAIN
PROTEIN

(Bacteroides
ovatus) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		5 PRO A  91
LEU A  94
ILE A 356
VAL A 111
LEU A  67
 None
 1.27A 3a51B-4zrxA:
undetectable		 3a51B-4zrxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		5 PRO A  73
ASN A  38
ILE A  98
PRO A  26
LEU A  24
 None
None
None
FMN  A7401 (-3.8A)
None
 1.29A 3a51B-5dxxA:
undetectable		 3a51B-5dxxA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewo STRUCTURAL PROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		5 LEU A 590
ASN A 445
MET A 442
VAL A 434
LEU A 436
 None
 1.39A 3a51B-5ewoA:
undetectable		 3a51B-5ewoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezu PROTEIN A46

(Vaccinia virus) 		no annotation 5 PRO A  67
THR A  70
LEU A  66
THR A  35
VAL A  32
 None
 1.44A 3a51B-5ezuA:
undetectable		 3a51B-5ezuA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 THR A 372
LEU A 332
ILE A 353
VAL A 232
PRO A 273
 None
 1.42A 3a51B-5fl7A:
undetectable		 3a51B-5fl7A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 THR A  58
LEU A  98
ILE A  91
THR A 165
LEU A 170
 None
 1.39A 3a51B-5gj8A:
undetectable		 3a51B-5gj8A:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		7 PRO A  83
LEU A  89
ILE A 235
THR A 240
VAL A 283
PRO A 287
LEU A 387
 None
None
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
None
 0.84A 3a51B-5gnmA:
56.4		 3a51B-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		8 PRO A  83
THR A  84
MET A  86
LEU A  89
ILE A 235
THR A 240
VAL A 283
PRO A 287
 None
None
None
None
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
 0.59A 3a51B-5gnmA:
56.4		 3a51B-5gnmA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		5 THR A  99
LEU A 112
ILE A  73
VAL A  63
LEU A 145
 None
 1.26A 3a51B-5hpjA:
undetectable		 3a51B-5hpjA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 5 LEU B 284
MET B 333
THR B 213
VAL B 216
LEU B 235
 None
 1.36A 3a51B-5hzgB:
undetectable		 3a51B-5hzgB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo7 VETISPIRADIENE
SYNTHASE 1

(Hyoscyamus
muticus) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 THR A  55
LEU A  59
ILE A  76
VAL A 117
LEU A 121
 None
 1.41A 3a51B-5jo7A:
0.8		 3a51B-5jo7A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Francisella
tularensis) 		PF00290
(Trp_syntA) 		5 ASN A  69
ILE A  37
THR A 257
VAL A 260
PRO A  22
 None
 1.22A 3a51B-5kzmA:
undetectable		 3a51B-5kzmA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 THR A 232
LEU A 233
ILE A 241
THR A 167
VAL A 162
 None
 1.16A 3a51B-5l5gA:
undetectable		 3a51B-5l5gA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 5 THR A  91
ASN A  25
ILE A 149
VAL A 125
LEU A 123
 None
 1.27A 3a51B-5m86A:
undetectable		 3a51B-5m86A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50) 		5 PRO A1485
LEU A1490
ASN A1453
VAL A1559
LEU A1528
 None
 1.43A 3a51B-5u1sA:
2.2		 3a51B-5u1sA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 ILE A  85
THR A  83
VAL A  79
PRO A  98
LEU A 100
 None
 1.41A 3a51B-5u24A:
undetectable		 3a51B-5u24A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 LYS A 468
ASN A 464
ILE A 398
PRO A 497
LEU A 510
 None
 1.23A 3a51B-5yj6A:
undetectable		 3a51B-5yj6A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM

(Bacillus
subtilis) 		no annotation 5 PRO A  55
MET A  72
LEU A  50
VAL A 206
LEU A 210
 None
 1.31A 3a51B-5zw4A:
undetectable		 3a51B-5zw4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA

(Norwalk virus) 		no annotation 5 PRO B 325
LEU B 309
ILE B 337
THR B 353
VAL B 387
 None
 1.40A 3a51B-6crjB:
undetectable		 3a51B-6crjB:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gl3 -

(-) 		no annotation 5 PRO A 370
THR A 371
MET A 609
ILE A 399
LEU A 359
 None
 1.34A 3a51B-6gl3A:
1.7		 3a51B-6gl3A:
undetectable