SIMILAR PATTERNS OF AMINO ACIDS FOR 3A51_A_VDYA6178_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 MET A 290
ILE A 301
ASN A 220
LEU A 288
ILE A 171
None
1.23A 3a51A-1evjA:
undetectable
3a51A-1evjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A 263
LEU A 255
ILE A  82
PRO A 111
LEU A   6
None
None
None
None
FAD  A 448 (-4.4A)
1.25A 3a51A-1f8wA:
0.0
3a51A-1f8wA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ


(Escherichia
virus G4)
PF02305
(Phage_F)
5 THR 1 406
MET 1 404
ILE 1  49
ASN 1 409
ILE 1  66
None
1.10A 3a51A-1gff1:
undetectable
3a51A-1gff1:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 MET A 342
ILE A 353
ASN A 272
LEU A 340
ILE A 223
None
1.17A 3a51A-1h6dA:
0.0
3a51A-1h6dA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io0 TROPOMODULIN

(Gallus gallus)
no annotation 5 THR A 234
ILE A 264
ASN A 201
VAL A 273
LEU A 285
None
1.04A 3a51A-1io0A:
undetectable
3a51A-1io0A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmo HEPARIN COFACTOR II

(Homo sapiens)
PF00079
(Serpin)
5 ILE A 270
LEU A 205
ILE A 408
VAL A 158
LEU A 398
None
0.92A 3a51A-1jmoA:
0.0
3a51A-1jmoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE


(Xanthomonas
citri)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
5 MET A  54
ILE A  52
ASN A 186
VAL A 115
LEU A  77
None
None
GOL  A3011 (-4.1A)
None
None
1.05A 3a51A-1mpxA:
0.0
3a51A-1mpxA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A


(Thermobifida
fusca)
PF00079
(Serpin)
5 THR A 212
MET A 210
LEU A 243
PRO A 235
LEU A  17
None
1.21A 3a51A-1mtpA:
undetectable
3a51A-1mtpA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT


(Klebsiella
pneumoniae)
PF08841
(DDR)
5 THR A  37
ILE A  46
LEU A  50
VAL A 387
LEU A  72
None
1.05A 3a51A-1nbwA:
undetectable
3a51A-1nbwA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrz PTS SYSTEM,
SORBOSE-SPECIFIC IIB
COMPONENT


(Klebsiella
pneumoniae)
PF03830
(PTSIIB_sorb)
5 MET A 108
ILE A   9
ILE A 154
VAL A 139
LEU A 134
None
1.22A 3a51A-1nrzA:
undetectable
3a51A-1nrzA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0u PROTEIN YWIB

(Bacillus
subtilis)
PF09148
(DUF1934)
5 ILE A   7
LEU A   9
ILE A 134
VAL A  39
LEU A 107
None
1.25A 3a51A-1r0uA:
undetectable
3a51A-1r0uA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3d ARSENATE REDUCTASE

(Escherichia
coli)
PF03960
(ArsC)
5 ILE A  92
LEU A  58
ILE A  48
THR A 103
PRO A  39
None
1.17A 3a51A-1s3dA:
undetectable
3a51A-1s3dA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sng COG4826: SERINE
PROTEASE INHIBITOR


(Thermobifida
fusca)
PF00079
(Serpin)
5 THR A 212
MET A 210
LEU A 243
PRO A 235
LEU A  17
None
1.27A 3a51A-1sngA:
undetectable
3a51A-1sngA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
5 MET A 635
ILE A 632
LEU A 637
THR A 739
LEU A 712
None
1.18A 3a51A-1suvA:
undetectable
3a51A-1suvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7f OUTER SURFACE
PROTEIN


(Bacillus cereus)
PF05913
(DUF871)
5 ILE A 163
ASN A 122
LEU A 219
ILE A 220
LEU A 199
None
1.04A 3a51A-1x7fA:
undetectable
3a51A-1x7fA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE


(Streptococcus
pyogenes)
PF00478
(IMPDH)
PF00571
(CBS)
5 ILE A  48
ASN A 282
ILE A 346
PRO A  47
LEU A 356
None
IMP  A 500 ( 4.5A)
None
None
None
1.15A 3a51A-1zfjA:
undetectable
3a51A-1zfjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE


(Pseudomonas
putida;
Spinacia
oleracea)
PF01070
(FMN_dh)
5 ILE A 345
LEU A 337
VAL A 304
PRO A  74
LEU A  75
None
1.08A 3a51A-2a7nA:
undetectable
3a51A-2a7nA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
GAMMA CHAIN


(Torpedo
marmorata)
PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb)
5 ILE E  55
LEU E  34
ILE E 208
VAL E  30
PRO E  87
None
1.24A 3a51A-2bg9E:
2.6
3a51A-2bg9E:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4)
PF09511
(RNA_lig_T4_1)
5 ILE A 217
LYS A 234
LEU A  79
ILE A  88
PRO A 214
None
1.10A 3a51A-2c5uA:
undetectable
3a51A-2c5uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9j GREEN FLUORESCENT
PROTEIN FP512


(Cerianthus
membranaceus)
PF01353
(GFP)
5 ILE A  75
ILE A 192
THR A 145
PRO A 187
LEU A 153
None
1.21A 3a51A-2c9jA:
undetectable
3a51A-2c9jA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE


(Pyrococcus
horikoshii)
PF00162
(PGK)
5 THR A  69
ILE A  87
THR A  13
VAL A 140
LEU A 137
None
1.00A 3a51A-2cunA:
undetectable
3a51A-2cunA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esp UBIQUITIN-CONJUGATIN
G ENZYME E2 D2


(Homo sapiens)
PF00179
(UQ_con)
5 ILE A  99
LEU A 103
ILE A 106
PRO A  65
LEU A  89
None
1.15A 3a51A-2espA:
undetectable
3a51A-2espA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 THR A 570
ILE A 718
LEU A 762
ILE A 765
VAL A 345
None
1.21A 3a51A-2iujA:
undetectable
3a51A-2iujA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwo MULTIPLE PDZ DOMAIN
PROTEIN


(Homo sapiens)
PF00595
(PDZ)
5 THR A1876
MET A1837
ILE A1912
LEU A1845
ILE A1847
None
1.24A 3a51A-2iwoA:
undetectable
3a51A-2iwoA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ko1 GTP
PYROPHOSPHOKINASE


(Chlorobaculum
tepidum)
PF13291
(ACT_4)
5 THR A  31
ILE A  26
LEU A  49
ILE A   8
VAL A  72
None
1.24A 3a51A-2ko1A:
undetectable
3a51A-2ko1A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B


(Saccharomyces
cerevisiae)
PF16846
(Cep3)
5 MET A 174
ILE A 171
LEU A 179
ILE A 182
LEU A 106
None
0.94A 3a51A-2quqA:
undetectable
3a51A-2quqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE


(Paraburkholderia
xenovorans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 MET A  80
ILE A 125
LEU A  78
VAL A  70
LEU A  65
None
1.24A 3a51A-2v7bA:
undetectable
3a51A-2v7bA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xbt CELLULOSOMAL
SCAFFOLDIN


(Pseudobacteroides
cellulosolvens)
PF00942
(CBM_3)
5 ILE A 113
LEU A  93
ILE A  45
VAL A 146
LEU A  12
None
0.93A 3a51A-2xbtA:
undetectable
3a51A-2xbtA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgt ASPARAGINYL-TRNA
SYNTHETASE,
CYTOPLASMIC


(Brugia malayi)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 THR A 428
LEU A 464
ILE A 472
VAL A 361
PRO A 384
None
1.14A 3a51A-2xgtA:
undetectable
3a51A-2xgtA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
6 MET A  74
ILE A  76
LEU A 226
ILE A 229
THR A 234
VAL A 277
PG4  A1399 ( 4.4A)
HEM  A1400 (-4.1A)
HEM  A1400 (-4.4A)
PG4  A1399 ( 4.5A)
HEM  A1400 (-3.7A)
HEM  A1400 (-4.5A)
0.69A 3a51A-2xkrA:
45.4
3a51A-2xkrA:
35.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT


(Methanosarcina
mazei)
PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7)
5 THR A  60
ILE A  51
THR A  38
VAL A  22
LEU A  18
None
1.21A 3a51A-2xr1A:
undetectable
3a51A-2xr1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER


(Escherichia
coli)
PF03797
(Autotransporter)
5 THR A1166
ILE A1096
THR A1311
VAL A1276
LEU A1255
None
0.97A 3a51A-3aehA:
undetectable
3a51A-3aehA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C


(Sulfurisphaera
tokodaii)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 THR C  75
ILE C  25
LEU C  18
ILE C  14
LEU C  34
None
1.08A 3a51A-3aizC:
undetectable
3a51A-3aizC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN


(Paracoccus
versutus)
PF06433
(Me-amine-dh_H)
5 THR H 359
ILE H 333
LEU H 355
ILE H 363
VAL H 377
None
1.09A 3a51A-3c75H:
undetectable
3a51A-3c75H:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK


(Xanthomonas
campestris)
no annotation 5 ILE A 139
ASN A  32
LEU A 179
ILE A 182
LEU A 159
None
1.26A 3a51A-3cv3A:
undetectable
3a51A-3cv3A:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE


(Corynebacterium
diphtheriae)
PF12897
(Aminotran_MocR)
5 ILE A 348
LEU A 327
ILE A 326
PRO A 393
LEU A 401
None
1.21A 3a51A-3d6kA:
undetectable
3a51A-3d6kA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eto NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1


(Homo sapiens)
PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP)
5 ILE A1719
ASN A1485
LEU A1713
VAL A1605
LEU A1575
None
1.05A 3a51A-3etoA:
undetectable
3a51A-3etoA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g04 THYROTROPIN RECEPTOR

(Homo sapiens)
PF13306
(LRR_5)
5 THR C 236
ILE C 216
LEU C 207
PRO C 242
LEU C 246
None
1.26A 3a51A-3g04C:
undetectable
3a51A-3g04C:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 ASN A 395
LEU A 146
THR A 189
VAL A 128
LEU A 129
None
1.22A 3a51A-3gg4A:
undetectable
3a51A-3gg4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 240
ASN A 121
ILE A 117
VAL A  30
LEU A   8
None
NAD  A 400 (-3.6A)
None
None
None
1.27A 3a51A-3gvhA:
undetectable
3a51A-3gvhA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR


(Chromobacterium
violaceum)
PF13377
(Peripla_BP_3)
5 THR A 133
MET A 155
ILE A 305
ASN A 107
ILE A  92
None
None
None
SO4  A   1 (-3.2A)
None
1.21A 3a51A-3h5oA:
undetectable
3a51A-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'


(Sulfolobus
solfataricus)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 THR A 514
ILE A 524
LEU A 509
ILE A 552
VAL A 530
None
1.24A 3a51A-3hkzA:
1.9
3a51A-3hkzA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i08 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 1


(Homo sapiens)
PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP)
5 ILE B1719
ASN A1485
LEU B1713
VAL A1605
LEU A1575
None
1.09A 3a51A-3i08B:
undetectable
3a51A-3i08B:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j23 CAPSID PROTEIN VP3

(Enterovirus A)
PF00073
(Rhv)
5 THR C 153
ILE C 133
LEU C 167
ILE C 169
VAL C  55
None
1.17A 3a51A-3j23C:
undetectable
3a51A-3j23C:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 CAPSID PROTEIN V20

(Mimivirus-dependent
virus Sputnik)
no annotation 5 ILE A 106
LEU A 238
ILE A 262
VAL A  71
LEU A 203
None
1.23A 3a51A-3j26A:
undetectable
3a51A-3j26A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP3

(Enterovirus B)
PF00073
(Rhv)
5 THR B 152
ILE B 132
LEU B 166
VAL B  55
LEU B  85
None
1.22A 3a51A-3j2jB:
undetectable
3a51A-3j2jB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8p DSL1

(Kluyveromyces
lactis)
PF11989
(Dsl1_C)
5 THR C 633
ILE C 600
THR C 541
VAL C 522
LEU C 526
None
1.02A 3a51A-3k8pC:
1.1
3a51A-3k8pC:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg6 PROTEASOME COMPONENT
C11


(Saccharomyces
cerevisiae)
PF00227
(Proteasome)
5 ILE J  59
LEU J  37
ILE J 101
VAL J  97
LEU J  87
None
1.24A 3a51A-3mg6J:
undetectable
3a51A-3mg6J:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nic ECO29KIR

(Escherichia
coli)
PF09517
(RE_Eco29kI)
5 ILE A 105
LEU A 101
ILE A 129
THR A  32
PRO A  39
None
1.17A 3a51A-3nicA:
undetectable
3a51A-3nicA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrv ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacterium
avium)
PF00378
(ECH_1)
5 ILE A  92
LEU A 114
THR A 151
VAL A 223
LEU A 227
None
1.16A 3a51A-3rrvA:
1.5
3a51A-3rrvA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb5 METHIONINE
AMINOPEPTIDASE


(Enterococcus
faecalis)
PF00557
(Peptidase_M24)
5 ILE A  91
LEU A  85
ILE A  35
VAL A  44
LEU A  27
None
1.19A 3a51A-3tb5A:
undetectable
3a51A-3tb5A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7b ENDO-1,4-BETA-XYLANA
SE


(Fusarium
oxysporum)
PF00331
(Glyco_hydro_10)
5 THR A 320
ILE A 269
LYS A  14
LEU A 246
LEU A 231
None
1.19A 3a51A-3u7bA:
undetectable
3a51A-3u7bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-4


(Saccharomyces
cerevisiae)
PF00227
(Proteasome)
5 ILE K  59
LEU K  37
ILE K 103
VAL K  99
LEU K  87
None
1.22A 3a51A-3wxrK:
undetectable
3a51A-3wxrK:
18.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zby P450 HEME-THIOLATE
PROTEIN


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 ILE A  79
LEU A 229
ILE A 232
THR A 237
VAL A 280
HEM  A1402 (-4.2A)
HEM  A1402 ( 4.6A)
None
HEM  A1402 (-3.7A)
HEM  A1402 (-4.4A)
0.63A 3a51A-3zbyA:
43.1
3a51A-3zbyA:
36.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh2 L-LACTATE
DEHYDROGENASE


(Plasmodium
falciparum)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 244
ASN A 127
ILE A 123
VAL A  31
LEU A   9
None
1.20A 3a51A-3zh2A:
undetectable
3a51A-3zh2A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2


(Homo sapiens)
PF00753
(Lactamase_B)
5 ILE A  93
ILE A  73
THR A  33
VAL A  18
LEU A  35
None
1.20A 3a51A-4ad9A:
undetectable
3a51A-4ad9A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN


(Chaetomium
thermophilum)
no annotation 5 LEU A 401
ILE A 407
THR A 369
VAL A 365
LEU A 445
None
1.13A 3a51A-4cyjA:
undetectable
3a51A-4cyjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ILE A1361
ASN A1178
LEU A1319
ILE A1322
VAL A1392
None
1.23A 3a51A-4fodA:
undetectable
3a51A-4fodA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxz SUPPRESSION OF
COPPER SENSITIVITY
PROTEIN


(Salmonella
enterica)
PF01323
(DSBA)
5 ILE A 119
LEU A 107
THR A  92
VAL A 131
LEU A 133
None
1.19A 3a51A-4gxzA:
undetectable
3a51A-4gxzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis)
PF15414
(DUF4621)
5 ILE A 121
LEU A 195
ILE A  99
VAL A 186
LEU A 221
None
1.21A 3a51A-4h3wA:
undetectable
3a51A-4h3wA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii3 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40


(Schizosaccharomyces
pombe)
PF00240
(ubiquitin)
5 THR B   9
ILE B  13
ILE B  36
VAL B  26
LEU B  43
None
1.17A 3a51A-4ii3B:
undetectable
3a51A-4ii3B:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqn PUTATIVE CYTOPLASMIC
PROTEIN


(Salmonella
enterica)
PF16728
(DUF5066)
5 ILE C 171
LEU C   8
ILE C   9
VAL C  70
LEU C  62
None
1.25A 3a51A-4iqnC:
undetectable
3a51A-4iqnC:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus)
PF00972
(Flavi_NS5)
PF01728
(FtsJ)
5 ILE A 571
ASN A 377
LEU A 556
VAL A 608
LEU A 612
None
1.08A 3a51A-4k6mA:
1.8
3a51A-4k6mA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtp RNA DEPENDENT RNA
POLYMERASE


(Japanese
encephalitis
virus)
PF00972
(Flavi_NS5)
5 ILE A 571
ASN A 377
LEU A 556
VAL A 608
LEU A 612
ILE  A 571 ( 0.7A)
ASN  A 377 ( 0.6A)
LEU  A 556 ( 0.6A)
VAL  A 608 ( 0.6A)
LEU  A 612 ( 0.6A)
1.09A 3a51A-4mtpA:
undetectable
3a51A-4mtpA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwt LYSOSOMAL PROTECTIVE
PROTEIN


(Homo sapiens)
PF00450
(Peptidase_S10)
5 LEU A 387
ILE A 419
VAL A 176
PRO A 157
LEU A 174
LEU  A 387 ( 0.6A)
ILE  A 419 ( 0.6A)
VAL  A 176 ( 0.6A)
PRO  A 157 ( 1.1A)
LEU  A 174 ( 0.5A)
1.04A 3a51A-4mwtA:
undetectable
3a51A-4mwtA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omb PHOSPHATE BINDING
PROTEIN


(Pseudomonas
aeruginosa)
PF12849
(PBP_like_2)
5 THR A 139
ILE A 146
LEU A 165
ILE A 135
VAL A 218
None
1.20A 3a51A-4ombA:
undetectable
3a51A-4ombA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2


(Mus musculus)
PF00008
(EGF)
PF03098
(An_peroxidase)
5 ASN A  39
ILE A 499
THR A 483
VAL A 510
PRO A 506
None
1.09A 3a51A-4ph9A:
undetectable
3a51A-4ph9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plh MALATE DEHYDROGENASE

(Apicomplexa)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 241
ASN A 122
ILE A 118
VAL A  31
LEU A   9
None
OXM  A 401 ( 3.3A)
None
None
None
1.22A 3a51A-4plhA:
undetectable
3a51A-4plhA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqj PHOSPHATE BINDING
PROTEIN


(Pseudomonas
aeruginosa)
PF12849
(PBP_like_2)
5 THR A 139
ILE A 146
LEU A 165
ILE A 135
VAL A 218
None
1.26A 3a51A-4pqjA:
undetectable
3a51A-4pqjA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtk WHITE-OPAQUE
REGULATOR 1


(Candida
albicans)
PF09729
(Gti1_Pac2)
5 ILE A  14
LEU A 231
ILE A  24
PRO A 248
LEU A 253
None
1.19A 3a51A-4qtkA:
undetectable
3a51A-4qtkA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens)
no annotation 5 THR C 218
ILE C 248
ASN C 185
ILE C 228
LEU C 269
None
0.90A 3a51A-4rwtC:
undetectable
3a51A-4rwtC:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x57 UBIQUITIN-CONJUGATIN
G ENZYME E2 8


(Arabidopsis
thaliana)
PF00179
(UQ_con)
5 ILE A  99
LEU A 103
ILE A 106
PRO A  65
LEU A  89
None
1.23A 3a51A-4x57A:
undetectable
3a51A-4x57A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkj D-LACTATE
DEHYDROGENASE


(Sporolactobacillus
inulinus)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 THR A  38
ILE A   4
ASN A  58
ILE A  50
VAL A 315
None
1.04A 3a51A-4xkjA:
undetectable
3a51A-4xkjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 ILE A 368
ILE A 373
VAL A 406
PRO A 402
LEU A 407
None
1.12A 3a51A-4xriA:
undetectable
3a51A-4xriA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)


(Homo sapiens)
no annotation 5 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
None
None
GOL  A 505 (-4.2A)
None
None
0.84A 3a51A-4z79A:
undetectable
3a51A-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)


(Homo sapiens)
no annotation 5 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
None
None
NI  A 509 (-4.0A)
None
None
0.84A 3a51A-4z8gA:
undetectable
3a51A-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
5 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
None
0.89A 3a51A-4z94G:
undetectable
3a51A-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT


(Corynebacterium
glutamicum)
PF01497
(Peripla_BP_2)
5 THR A 138
ILE A 162
LEU A 143
ILE A 148
THR A 178
None
1.25A 3a51A-5az3A:
undetectable
3a51A-5az3A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b16 RIBONUCLEASE
3,DROSHA,RIBONUCLEAS
E
3,DROSHA,RIBONUCLEAS
E 3


(Homo sapiens)
PF00035
(dsrm)
PF00636
(Ribonuclease_3)
PF14622
(Ribonucleas_3_3)
6 THR A 416
ILE A 702
LYS A 694
THR A 590
VAL A 856
PRO A 683
None
1.14A 3a51A-5b16A:
undetectable
3a51A-5b16A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens)
PF00240
(ubiquitin)
5 THR A  85
ILE A  89
ILE A 112
VAL A 102
LEU A 119
None
1.19A 3a51A-5b83A:
undetectable
3a51A-5b83A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE


(Coccidioides
immitis)
PF00149
(Metallophos)
5 ILE A 216
LEU A 214
ILE A 208
VAL A 105
LEU A 132
None
1.21A 3a51A-5b8iA:
undetectable
3a51A-5b8iA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4v NUCLEOPROTEIN,PHOSPH
OPROTEIN


(Measles
morbillivirus)
PF00973
(Paramyxo_ncap)
PF13825
(Paramyxo_PNT)
5 ILE A  57
LEU A  33
ILE A 136
THR A 150
LEU A 192
None
1.26A 3a51A-5e4vA:
undetectable
3a51A-5e4vA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez7 FLAVOENZYME PA4991

(Pseudomonas
aeruginosa)
PF01266
(DAO)
5 ILE A  16
LEU A 346
ILE A  52
VAL A  93
LEU A  90
FAD  A 401 (-4.8A)
FAD  A 401 (-4.3A)
None
None
None
1.08A 3a51A-5ez7A:
undetectable
3a51A-5ez7A:
25.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
6 ILE A  88
ILE A 235
THR A 240
VAL A 283
PRO A 287
LEU A 387
HEM  A 501 ( 4.4A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
None
0.79A 3a51A-5gnmA:
56.7
3a51A-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
8 THR A  84
MET A  86
ILE A  88
LEU A 232
ILE A 235
THR A 240
VAL A 283
PRO A 287
None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.7A)
HEM  A 501 (-4.7A)
HEM  A 501 (-3.5A)
0.55A 3a51A-5gnmA:
56.7
3a51A-5gnmA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3c PROTEIN SUPPRESSOR
OF NPR1-1,
CONSTITUTIVE 1


(Arabidopsis
thaliana)
PF01582
(TIR)
5 ILE A  77
LEU A 174
ILE A 171
VAL A  32
LEU A  37
None
1.11A 3a51A-5h3cA:
undetectable
3a51A-5h3cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE


(Saccharomyces
cerevisiae)
PF04752
(ChaC)
5 ILE A  17
ASN A 131
LEU A 204
ILE A  93
LEU A  11
None
1.26A 3a51A-5hwiA:
undetectable
3a51A-5hwiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icl LIPOATE--PROTEIN
LIGASE


(Enterococcus
faecalis)
PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C)
5 THR A 198
ILE A 205
ASN A   9
LEU A 150
LEU A  32
None
1.26A 3a51A-5iclA:
undetectable
3a51A-5iclA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Francisella
tularensis)
PF00290
(Trp_syntA)
5 ASN A  69
ILE A  37
THR A 257
VAL A 260
PRO A  22
None
1.20A 3a51A-5kzmA:
undetectable
3a51A-5kzmA:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l94 CYTOCHROME P450

(Bacillus
megaterium)
PF00067
(p450)
6 ILE A  85
LYS A 187
LEU A 238
ILE A 241
THR A 246
VAL A 289
HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.4A)
TES  A 502 (-4.8A)
0.43A 3a51A-5l94A:
49.3
3a51A-5l94A:
34.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-)
no annotation 5 THR A  70
ILE A 388
ASN A  73
ILE A 309
LEU A 552
None
1.21A 3a51A-5mz9A:
undetectable
3a51A-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN


(Treponema
pallidum)
PF01547
(SBP_bac_1)
5 ASN A 392
LEU A 217
ILE A 384
VAL A 237
LEU A 201
None
None
None
None
BR  A 501 ( 4.6A)
1.16A 3a51A-5u2pA:
undetectable
3a51A-5u2pA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 240
ASN A 121
ILE A 117
VAL A  30
LEU A   8
None
1.26A 3a51A-5ulvA:
undetectable
3a51A-5ulvA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Listeria
monocytogenes)
PF00478
(IMPDH)
5 ILE A  46
ASN A 280
ILE A 344
PRO A  45
LEU A 354
None
IMP  A 500 ( 4.3A)
None
None
None
1.24A 3a51A-5upyA:
undetectable
3a51A-5upyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL


(Homo sapiens)
PF00384
(Molybdopterin)
PF09326
(NADH_dhqG_C)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
5 ILE M 418
ILE M 391
VAL M 475
PRO M 407
LEU M 516
None
1.11A 3a51A-5xtbM:
undetectable
3a51A-5xtbM:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE


(Saccharomyces
cerevisiae)
PF00201
(UDPGT)
PF03033
(Glyco_transf_28)
5 THR A 960
ILE A1148
ILE A1155
VAL A 770
LEU A 744
None
1.15A 3a51A-5xvmA:
undetectable
3a51A-5xvmA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53


(Saccharomyces
cerevisiae)
no annotation 5 ILE A 130
LEU A 101
THR A 106
VAL A 134
LEU A  78
None
1.24A 3a51A-5xzwA:
undetectable
3a51A-5xzwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN


(Ruminiclostridium
thermocellum)
no annotation 5 LYS A 468
ASN A 464
ILE A 398
PRO A 497
LEU A 510
None
1.19A 3a51A-5yj6A:
undetectable
3a51A-5yj6A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei)
no annotation 5 ILE A 107
LEU A 252
ILE A 255
THR A 260
VAL A 303
HEM  A 501 (-4.2A)
HEM  A 501 ( 4.6A)
None
HEM  A 501 (-3.7A)
None
0.75A 3a51A-5ysmA:
39.7
3a51A-5ysmA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ep3 -

(-)
no annotation 5 ILE A  20
ASN A  65
LEU A  54
ILE A  51
LEU A  36
None
1.20A 3a51A-6ep3A:
undetectable
3a51A-6ep3A:
undetectable