SIMILAR PATTERNS OF AMINO ACIDS FOR 3A51_A_VDYA6178_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evj | GLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | MET A 290ILE A 301ASN A 220LEU A 288ILE A 171 | None | 1.23A | 3a51A-1evjA:undetectable | 3a51A-1evjA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f8w | NADH PEROXIDASE (Enterococcusfaecalis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 263LEU A 255ILE A 82PRO A 111LEU A 6 | NoneNoneNoneNoneFAD A 448 (-4.4A) | 1.25A | 3a51A-1f8wA:0.0 | 3a51A-1f8wA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gff | BACTERIOPHAGE G4CAPSID PROTEINS GPF,GPG, GPJ (Escherichiavirus G4) |
PF02305(Phage_F) | 5 | THR 1 406MET 1 404ILE 1 49ASN 1 409ILE 1 66 | None | 1.10A | 3a51A-1gff1:undetectable | 3a51A-1gff1:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h6d | PRECURSOR FORM OFGLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | MET A 342ILE A 353ASN A 272LEU A 340ILE A 223 | None | 1.17A | 3a51A-1h6dA:0.0 | 3a51A-1h6dA:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1io0 | TROPOMODULIN (Gallus gallus) |
no annotation | 5 | THR A 234ILE A 264ASN A 201VAL A 273LEU A 285 | None | 1.04A | 3a51A-1io0A:undetectable | 3a51A-1io0A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jmo | HEPARIN COFACTOR II (Homo sapiens) |
PF00079(Serpin) | 5 | ILE A 270LEU A 205ILE A 408VAL A 158LEU A 398 | None | 0.92A | 3a51A-1jmoA:0.0 | 3a51A-1jmoA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mpx | ALPHA-AMINO ACIDESTER HYDROLASE (Xanthomonascitri) |
PF02129(Peptidase_S15)PF08530(PepX_C) | 5 | MET A 54ILE A 52ASN A 186VAL A 115LEU A 77 | NoneNoneGOL A3011 (-4.1A)NoneNone | 1.05A | 3a51A-1mpxA:0.0 | 3a51A-1mpxA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mtp | SERINE PROTEINASEINHIBITOR (SERPIN),CHAIN A (Thermobifidafusca) |
PF00079(Serpin) | 5 | THR A 212MET A 210LEU A 243PRO A 235LEU A 17 | None | 1.21A | 3a51A-1mtpA:undetectable | 3a51A-1mtpA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nbw | GLYCEROL DEHYDRATASEREACTIVASE ALPHASUBUNIT (Klebsiellapneumoniae) |
PF08841(DDR) | 5 | THR A 37ILE A 46LEU A 50VAL A 387LEU A 72 | None | 1.05A | 3a51A-1nbwA:undetectable | 3a51A-1nbwA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nrz | PTS SYSTEM,SORBOSE-SPECIFIC IIBCOMPONENT (Klebsiellapneumoniae) |
PF03830(PTSIIB_sorb) | 5 | MET A 108ILE A 9ILE A 154VAL A 139LEU A 134 | None | 1.22A | 3a51A-1nrzA:undetectable | 3a51A-1nrzA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r0u | PROTEIN YWIB (Bacillussubtilis) |
PF09148(DUF1934) | 5 | ILE A 7LEU A 9ILE A 134VAL A 39LEU A 107 | None | 1.25A | 3a51A-1r0uA:undetectable | 3a51A-1r0uA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s3d | ARSENATE REDUCTASE (Escherichiacoli) |
PF03960(ArsC) | 5 | ILE A 92LEU A 58ILE A 48THR A 103PRO A 39 | None | 1.17A | 3a51A-1s3dA:undetectable | 3a51A-1s3dA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sng | COG4826: SERINEPROTEASE INHIBITOR (Thermobifidafusca) |
PF00079(Serpin) | 5 | THR A 212MET A 210LEU A 243PRO A 235LEU A 17 | None | 1.27A | 3a51A-1sngA:undetectable | 3a51A-1sngA:25.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1suv | TRANSFERRIN RECEPTORPROTEIN 1 (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | MET A 635ILE A 632LEU A 637THR A 739LEU A 712 | None | 1.18A | 3a51A-1suvA:undetectable | 3a51A-1suvA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x7f | OUTER SURFACEPROTEIN (Bacillus cereus) |
PF05913(DUF871) | 5 | ILE A 163ASN A 122LEU A 219ILE A 220LEU A 199 | None | 1.04A | 3a51A-1x7fA:undetectable | 3a51A-1x7fA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zfj | INOSINEMONOPHOSPHATEDEHYDROGENASE (Streptococcuspyogenes) |
PF00478(IMPDH)PF00571(CBS) | 5 | ILE A 48ASN A 282ILE A 346PRO A 47LEU A 356 | NoneIMP A 500 ( 4.5A)NoneNoneNone | 1.15A | 3a51A-1zfjA:undetectable | 3a51A-1zfjA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a7n | L(+)-MANDELATEDEHYDROGENASE (Pseudomonasputida;Spinaciaoleracea) |
PF01070(FMN_dh) | 5 | ILE A 345LEU A 337VAL A 304PRO A 74LEU A 75 | None | 1.08A | 3a51A-2a7nA:undetectable | 3a51A-2a7nA:24.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bg9 | ACETYLCHOLINERECEPTOR PROTEIN,GAMMA CHAIN (Torpedomarmorata) |
PF02931(Neur_chan_LBD)PF02932(Neur_chan_memb) | 5 | ILE E 55LEU E 34ILE E 208VAL E 30PRO E 87 | None | 1.24A | 3a51A-2bg9E:2.6 | 3a51A-2bg9E:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c5u | RNA LIGASE (Escherichiavirus T4) |
PF09511(RNA_lig_T4_1) | 5 | ILE A 217LYS A 234LEU A 79ILE A 88PRO A 214 | None | 1.10A | 3a51A-2c5uA:undetectable | 3a51A-2c5uA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c9j | GREEN FLUORESCENTPROTEIN FP512 (Cerianthusmembranaceus) |
PF01353(GFP) | 5 | ILE A 75ILE A 192THR A 145PRO A 187LEU A 153 | None | 1.21A | 3a51A-2c9jA:undetectable | 3a51A-2c9jA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cun | PHOSPHOGLYCERATEKINASE (Pyrococcushorikoshii) |
PF00162(PGK) | 5 | THR A 69ILE A 87THR A 13VAL A 140LEU A 137 | None | 1.00A | 3a51A-2cunA:undetectable | 3a51A-2cunA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2esp | UBIQUITIN-CONJUGATING ENZYME E2 D2 (Homo sapiens) |
PF00179(UQ_con) | 5 | ILE A 99LEU A 103ILE A 106PRO A 65LEU A 89 | None | 1.15A | 3a51A-2espA:undetectable | 3a51A-2espA:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iuj | LIPOXYGENASE L-5 (Glycine max) |
PF00305(Lipoxygenase)PF01477(PLAT) | 5 | THR A 570ILE A 718LEU A 762ILE A 765VAL A 345 | None | 1.21A | 3a51A-2iujA:undetectable | 3a51A-2iujA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwo | MULTIPLE PDZ DOMAINPROTEIN (Homo sapiens) |
PF00595(PDZ) | 5 | THR A1876MET A1837ILE A1912LEU A1845ILE A1847 | None | 1.24A | 3a51A-2iwoA:undetectable | 3a51A-2iwoA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ko1 | GTPPYROPHOSPHOKINASE (Chlorobaculumtepidum) |
PF13291(ACT_4) | 5 | THR A 31ILE A 26LEU A 49ILE A 8VAL A 72 | None | 1.24A | 3a51A-2ko1A:undetectable | 3a51A-2ko1A:10.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2quq | CENTROMEREDNA-BINDING PROTEINCOMPLEX CBF3 SUBUNITB (Saccharomycescerevisiae) |
PF16846(Cep3) | 5 | MET A 174ILE A 171LEU A 179ILE A 182LEU A 106 | None | 0.94A | 3a51A-2quqA:undetectable | 3a51A-2quqA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7b | BENZOATE-COENZYME ALIGASE (Paraburkholderiaxenovorans) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | MET A 80ILE A 125LEU A 78VAL A 70LEU A 65 | None | 1.24A | 3a51A-2v7bA:undetectable | 3a51A-2v7bA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xbt | CELLULOSOMALSCAFFOLDIN (Pseudobacteroidescellulosolvens) |
PF00942(CBM_3) | 5 | ILE A 113LEU A 93ILE A 45VAL A 146LEU A 12 | None | 0.93A | 3a51A-2xbtA:undetectable | 3a51A-2xbtA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xgt | ASPARAGINYL-TRNASYNTHETASE,CYTOPLASMIC (Brugia malayi) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | THR A 428LEU A 464ILE A 472VAL A 361PRO A 384 | None | 1.14A | 3a51A-2xgtA:undetectable | 3a51A-2xgtA:19.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xkr | PUTATIVE CYTOCHROMEP450 142 (Mycobacteriumtuberculosis) |
PF00067(p450) | 6 | MET A 74ILE A 76LEU A 226ILE A 229THR A 234VAL A 277 | PG4 A1399 ( 4.4A)HEM A1400 (-4.1A)HEM A1400 (-4.4A)PG4 A1399 ( 4.5A)HEM A1400 (-3.7A)HEM A1400 (-4.5A) | 0.69A | 3a51A-2xkrA:45.4 | 3a51A-2xkrA:35.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xr1 | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR100 KD SUBUNIT (Methanosarcinamazei) |
PF07521(RMMBL)PF07650(KH_2)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | THR A 60ILE A 51THR A 38VAL A 22LEU A 18 | None | 1.21A | 3a51A-2xr1A:undetectable | 3a51A-2xr1A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aeh | HEMOGLOBIN-BINDINGPROTEASE HBPAUTOTRANSPORTER (Escherichiacoli) |
PF03797(Autotransporter) | 5 | THR A1166ILE A1096THR A1311VAL A1276LEU A1255 | None | 0.97A | 3a51A-3aehA:undetectable | 3a51A-3aehA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aiz | DNA POLYMERASESLIDING CLAMP C (Sulfurisphaeratokodaii) |
PF00705(PCNA_N)PF02747(PCNA_C) | 5 | THR C 75ILE C 25LEU C 18ILE C 14LEU C 34 | None | 1.08A | 3a51A-3aizC:undetectable | 3a51A-3aizC:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c75 | METHYLAMINEDEHYDROGENASE HEAVYCHAIN (Paracoccusversutus) |
PF06433(Me-amine-dh_H) | 5 | THR H 359ILE H 333LEU H 355ILE H 363VAL H 377 | None | 1.09A | 3a51A-3c75H:undetectable | 3a51A-3c75H:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cv3 | GLUCURONOSYLTRANSFERASE GUMK (Xanthomonascampestris) |
no annotation | 5 | ILE A 139ASN A 32LEU A 179ILE A 182LEU A 159 | None | 1.26A | 3a51A-3cv3A:undetectable | 3a51A-3cv3A:26.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d6k | PUTATIVEAMINOTRANSFERASE (Corynebacteriumdiphtheriae) |
PF12897(Aminotran_MocR) | 5 | ILE A 348LEU A 327ILE A 326PRO A 393LEU A 401 | None | 1.21A | 3a51A-3d6kA:undetectable | 3a51A-3d6kA:23.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eto | NEUROGENIC LOCUSNOTCH HOMOLOGPROTEIN 1 (Homo sapiens) |
PF00066(Notch)PF06816(NOD)PF07684(NODP) | 5 | ILE A1719ASN A1485LEU A1713VAL A1605LEU A1575 | None | 1.05A | 3a51A-3etoA:undetectable | 3a51A-3etoA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g04 | THYROTROPIN RECEPTOR (Homo sapiens) |
PF13306(LRR_5) | 5 | THR C 236ILE C 216LEU C 207PRO C 242LEU C 246 | None | 1.26A | 3a51A-3g04C:undetectable | 3a51A-3g04C:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gg4 | GLYCEROL KINASE (Yersiniapseudotuberculosis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ASN A 395LEU A 146THR A 189VAL A 128LEU A 129 | None | 1.22A | 3a51A-3gg4A:undetectable | 3a51A-3gg4A:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvh | MALATE DEHYDROGENASE (Brucellaabortus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 240ASN A 121ILE A 117VAL A 30LEU A 8 | NoneNAD A 400 (-3.6A)NoneNoneNone | 1.27A | 3a51A-3gvhA:undetectable | 3a51A-3gvhA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5o | TRANSCRIPTIONALREGULATOR GNTR (Chromobacteriumviolaceum) |
PF13377(Peripla_BP_3) | 5 | THR A 133MET A 155ILE A 305ASN A 107ILE A 92 | NoneNoneNoneSO4 A 1 (-3.2A)None | 1.21A | 3a51A-3h5oA:undetectable | 3a51A-3h5oA:25.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hkz | DNA-DIRECTED RNAPOLYMERASE SUBUNITA' (Sulfolobussolfataricus) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | THR A 514ILE A 524LEU A 509ILE A 552VAL A 530 | None | 1.24A | 3a51A-3hkzA:1.9 | 3a51A-3hkzA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i08 | NEUROGENIC LOCUSNOTCH HOMOLOGPROTEIN 1 (Homo sapiens) |
PF00066(Notch)PF06816(NOD)PF07684(NODP) | 5 | ILE B1719ASN A1485LEU B1713VAL A1605LEU A1575 | None | 1.09A | 3a51A-3i08B:undetectable | 3a51A-3i08B:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j23 | CAPSID PROTEIN VP3 (Enterovirus A) |
PF00073(Rhv) | 5 | THR C 153ILE C 133LEU C 167ILE C 169VAL C 55 | None | 1.17A | 3a51A-3j23C:undetectable | 3a51A-3j23C:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j26 | CAPSID PROTEIN V20 (Mimivirus-dependentvirus Sputnik) |
no annotation | 5 | ILE A 106LEU A 238ILE A 262VAL A 71LEU A 203 | None | 1.23A | 3a51A-3j26A:undetectable | 3a51A-3j26A:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2j | PROTEIN VP3 (Enterovirus B) |
PF00073(Rhv) | 5 | THR B 152ILE B 132LEU B 166VAL B 55LEU B 85 | None | 1.22A | 3a51A-3j2jB:undetectable | 3a51A-3j2jB:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8p | DSL1 (Kluyveromyceslactis) |
PF11989(Dsl1_C) | 5 | THR C 633ILE C 600THR C 541VAL C 522LEU C 526 | None | 1.02A | 3a51A-3k8pC:1.1 | 3a51A-3k8pC:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mg6 | PROTEASOME COMPONENTC11 (Saccharomycescerevisiae) |
PF00227(Proteasome) | 5 | ILE J 59LEU J 37ILE J 101VAL J 97LEU J 87 | None | 1.24A | 3a51A-3mg6J:undetectable | 3a51A-3mg6J:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nic | ECO29KIR (Escherichiacoli) |
PF09517(RE_Eco29kI) | 5 | ILE A 105LEU A 101ILE A 129THR A 32PRO A 39 | None | 1.17A | 3a51A-3nicA:undetectable | 3a51A-3nicA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rrv | ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteriumavium) |
PF00378(ECH_1) | 5 | ILE A 92LEU A 114THR A 151VAL A 223LEU A 227 | None | 1.16A | 3a51A-3rrvA:1.5 | 3a51A-3rrvA:24.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tb5 | METHIONINEAMINOPEPTIDASE (Enterococcusfaecalis) |
PF00557(Peptidase_M24) | 5 | ILE A 91LEU A 85ILE A 35VAL A 44LEU A 27 | None | 1.19A | 3a51A-3tb5A:undetectable | 3a51A-3tb5A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u7b | ENDO-1,4-BETA-XYLANASE (Fusariumoxysporum) |
PF00331(Glyco_hydro_10) | 5 | THR A 320ILE A 269LYS A 14LEU A 246LEU A 231 | None | 1.19A | 3a51A-3u7bA:undetectable | 3a51A-3u7bA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxr | PROTEASOME SUBUNITBETA TYPE-4 (Saccharomycescerevisiae) |
PF00227(Proteasome) | 5 | ILE K 59LEU K 37ILE K 103VAL K 99LEU K 87 | None | 1.22A | 3a51A-3wxrK:undetectable | 3a51A-3wxrK:18.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zby | P450 HEME-THIOLATEPROTEIN (Mycolicibacteriumsmegmatis) |
PF00067(p450) | 5 | ILE A 79LEU A 229ILE A 232THR A 237VAL A 280 | HEM A1402 (-4.2A)HEM A1402 ( 4.6A)NoneHEM A1402 (-3.7A)HEM A1402 (-4.4A) | 0.63A | 3a51A-3zbyA:43.1 | 3a51A-3zbyA:36.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zh2 | L-LACTATEDEHYDROGENASE (Plasmodiumfalciparum) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 244ASN A 127ILE A 123VAL A 31LEU A 9 | None | 1.20A | 3a51A-3zh2A:undetectable | 3a51A-3zh2A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ad9 | BETA-LACTAMASE-LIKEPROTEIN 2 (Homo sapiens) |
PF00753(Lactamase_B) | 5 | ILE A 93ILE A 73THR A 33VAL A 18LEU A 35 | None | 1.20A | 3a51A-4ad9A:undetectable | 3a51A-4ad9A:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cyj | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN3-LIKE PROTEIN (Chaetomiumthermophilum) |
no annotation | 5 | LEU A 401ILE A 407THR A 369VAL A 365LEU A 445 | None | 1.13A | 3a51A-4cyjA:undetectable | 3a51A-4cyjA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fod | ALK TYROSINE KINASERECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ILE A1361ASN A1178LEU A1319ILE A1322VAL A1392 | None | 1.23A | 3a51A-4fodA:undetectable | 3a51A-4fodA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gxz | SUPPRESSION OFCOPPER SENSITIVITYPROTEIN (Salmonellaenterica) |
PF01323(DSBA) | 5 | ILE A 119LEU A 107THR A 92VAL A 131LEU A 133 | None | 1.19A | 3a51A-4gxzA:undetectable | 3a51A-4gxzA:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h3w | HYPOTHETICAL PROTEIN (Parabacteroidesdistasonis) |
PF15414(DUF4621) | 5 | ILE A 121LEU A 195ILE A 99VAL A 186LEU A 221 | None | 1.21A | 3a51A-4h3wA:undetectable | 3a51A-4h3wA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ii3 | UBIQUITIN-60SRIBOSOMAL PROTEINL40 (Schizosaccharomycespombe) |
PF00240(ubiquitin) | 5 | THR B 9ILE B 13ILE B 36VAL B 26LEU B 43 | None | 1.17A | 3a51A-4ii3B:undetectable | 3a51A-4ii3B:14.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iqn | PUTATIVE CYTOPLASMICPROTEIN (Salmonellaenterica) |
PF16728(DUF5066) | 5 | ILE C 171LEU C 8ILE C 9VAL C 70LEU C 62 | None | 1.25A | 3a51A-4iqnC:undetectable | 3a51A-4iqnC:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6m | POLYPROTEIN (Japaneseencephalitisvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 5 | ILE A 571ASN A 377LEU A 556VAL A 608LEU A 612 | None | 1.08A | 3a51A-4k6mA:1.8 | 3a51A-4k6mA:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mtp | RNA DEPENDENT RNAPOLYMERASE (Japaneseencephalitisvirus) |
PF00972(Flavi_NS5) | 5 | ILE A 571ASN A 377LEU A 556VAL A 608LEU A 612 | ILE A 571 ( 0.7A)ASN A 377 ( 0.6A)LEU A 556 ( 0.6A)VAL A 608 ( 0.6A)LEU A 612 ( 0.6A) | 1.09A | 3a51A-4mtpA:undetectable | 3a51A-4mtpA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mwt | LYSOSOMAL PROTECTIVEPROTEIN (Homo sapiens) |
PF00450(Peptidase_S10) | 5 | LEU A 387ILE A 419VAL A 176PRO A 157LEU A 174 | LEU A 387 ( 0.6A)ILE A 419 ( 0.6A)VAL A 176 ( 0.6A)PRO A 157 ( 1.1A)LEU A 174 ( 0.5A) | 1.04A | 3a51A-4mwtA:undetectable | 3a51A-4mwtA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4omb | PHOSPHATE BINDINGPROTEIN (Pseudomonasaeruginosa) |
PF12849(PBP_like_2) | 5 | THR A 139ILE A 146LEU A 165ILE A 135VAL A 218 | None | 1.20A | 3a51A-4ombA:undetectable | 3a51A-4ombA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 5 | ASN A 39ILE A 499THR A 483VAL A 510PRO A 506 | None | 1.09A | 3a51A-4ph9A:undetectable | 3a51A-4ph9A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4plh | MALATE DEHYDROGENASE (Apicomplexa) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 241ASN A 122ILE A 118VAL A 31LEU A 9 | NoneOXM A 401 ( 3.3A)NoneNoneNone | 1.22A | 3a51A-4plhA:undetectable | 3a51A-4plhA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pqj | PHOSPHATE BINDINGPROTEIN (Pseudomonasaeruginosa) |
PF12849(PBP_like_2) | 5 | THR A 139ILE A 146LEU A 165ILE A 135VAL A 218 | None | 1.26A | 3a51A-4pqjA:undetectable | 3a51A-4pqjA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qtk | WHITE-OPAQUEREGULATOR 1 (Candidaalbicans) |
PF09729(Gti1_Pac2) | 5 | ILE A 14LEU A 231ILE A 24PRO A 248LEU A 253 | None | 1.19A | 3a51A-4qtkA:undetectable | 3a51A-4qtkA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rwt | LEIOMODIN-2 (Homo sapiens) |
no annotation | 5 | THR C 218ILE C 248ASN C 185ILE C 228LEU C 269 | None | 0.90A | 3a51A-4rwtC:undetectable | 3a51A-4rwtC:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x57 | UBIQUITIN-CONJUGATING ENZYME E2 8 (Arabidopsisthaliana) |
PF00179(UQ_con) | 5 | ILE A 99LEU A 103ILE A 106PRO A 65LEU A 89 | None | 1.23A | 3a51A-4x57A:undetectable | 3a51A-4x57A:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xkj | D-LACTATEDEHYDROGENASE (Sporolactobacillusinulinus) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | THR A 38ILE A 4ASN A 58ILE A 50VAL A 315 | None | 1.04A | 3a51A-4xkjA:undetectable | 3a51A-4xkjA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xri | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 5 | ILE A 368ILE A 373VAL A 406PRO A 402LEU A 407 | None | 1.12A | 3a51A-4xriA:undetectable | 3a51A-4xriA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z79 | LEIOMODIN-1ACTIN-BINDING SITE 2(ABS2) (Homo sapiens) |
no annotation | 5 | THR A 369ILE A 399ASN A 336ILE A 379LEU A 420 | NoneNoneGOL A 505 (-4.2A)NoneNone | 0.84A | 3a51A-4z79A:undetectable | 3a51A-4z79A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8g | TROPOMODULIN-1,LEIOMODIN-1 CHIMERA(TP1 ABS2) (Homo sapiens) |
no annotation | 5 | THR A 369ILE A 399ASN A 201ILE A 379LEU A 420 | NoneNone NI A 509 (-4.0A)NoneNone | 0.84A | 3a51A-4z8gA:undetectable | 3a51A-4z8gA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z94 | GELSOLIN,TROPOMODULIN-1,LEIOMODIN-1 CHIMERA (Homo sapiens) |
PF00626(Gelsolin) | 5 | THR G1369ILE G1399ASN G1201ILE G1379LEU G1420 | None | 0.89A | 3a51A-4z94G:undetectable | 3a51A-4z94G:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az3 | ABC-TYPETRANSPORTER,PERIPLASMICCOMPONENT (Corynebacteriumglutamicum) |
PF01497(Peripla_BP_2) | 5 | THR A 138ILE A 162LEU A 143ILE A 148THR A 178 | None | 1.25A | 3a51A-5az3A:undetectable | 3a51A-5az3A:27.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b16 | RIBONUCLEASE3,DROSHA,RIBONUCLEASE3,DROSHA,RIBONUCLEASE 3 (Homo sapiens) |
PF00035(dsrm)PF00636(Ribonuclease_3)PF14622(Ribonucleas_3_3) | 6 | THR A 416ILE A 702LYS A 694THR A 590VAL A 856PRO A 683 | None | 1.14A | 3a51A-5b16A:undetectable | 3a51A-5b16A:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b83 | TETRA UBIQUITIN (Homo sapiens) |
PF00240(ubiquitin) | 5 | THR A 85ILE A 89ILE A 112VAL A 102LEU A 119 | None | 1.19A | 3a51A-5b83A:undetectable | 3a51A-5b83A:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b8i | SERINE/THREONINE-PROTEIN PHOSPHATASE (Coccidioidesimmitis) |
PF00149(Metallophos) | 5 | ILE A 216LEU A 214ILE A 208VAL A 105LEU A 132 | None | 1.21A | 3a51A-5b8iA:undetectable | 3a51A-5b8iA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4v | NUCLEOPROTEIN,PHOSPHOPROTEIN (Measlesmorbillivirus) |
PF00973(Paramyxo_ncap)PF13825(Paramyxo_PNT) | 5 | ILE A 57LEU A 33ILE A 136THR A 150LEU A 192 | None | 1.26A | 3a51A-5e4vA:undetectable | 3a51A-5e4vA:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ez7 | FLAVOENZYME PA4991 (Pseudomonasaeruginosa) |
PF01266(DAO) | 5 | ILE A 16LEU A 346ILE A 52VAL A 93LEU A 90 | FAD A 401 (-4.8A)FAD A 401 (-4.3A)NoneNoneNone | 1.08A | 3a51A-5ez7A:undetectable | 3a51A-5ez7A:25.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 6 | ILE A 88ILE A 235THR A 240VAL A 283PRO A 287LEU A 387 | HEM A 501 ( 4.4A)NoneHEM A 501 (-3.7A)HEM A 501 (-4.7A)HEM A 501 (-3.5A)None | 0.79A | 3a51A-5gnmA:56.7 | 3a51A-5gnmA:98.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 8 | THR A 84MET A 86ILE A 88LEU A 232ILE A 235THR A 240VAL A 283PRO A 287 | NoneNoneHEM A 501 ( 4.4A)HEM A 501 ( 4.7A)NoneHEM A 501 (-3.7A)HEM A 501 (-4.7A)HEM A 501 (-3.5A) | 0.55A | 3a51A-5gnmA:56.7 | 3a51A-5gnmA:98.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3c | PROTEIN SUPPRESSOROF NPR1-1,CONSTITUTIVE 1 (Arabidopsisthaliana) |
PF01582(TIR) | 5 | ILE A 77LEU A 174ILE A 171VAL A 32LEU A 37 | None | 1.11A | 3a51A-5h3cA:undetectable | 3a51A-5h3cA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hwi | GLUTATHIONE-SPECIFICGAMMA-GLUTAMYLCYCLOTRANSFERASE (Saccharomycescerevisiae) |
PF04752(ChaC) | 5 | ILE A 17ASN A 131LEU A 204ILE A 93LEU A 11 | None | 1.26A | 3a51A-5hwiA:undetectable | 3a51A-5hwiA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5icl | LIPOATE--PROTEINLIGASE (Enterococcusfaecalis) |
PF03099(BPL_LplA_LipB)PF10437(Lip_prot_lig_C) | 5 | THR A 198ILE A 205ASN A 9LEU A 150LEU A 32 | None | 1.26A | 3a51A-5iclA:undetectable | 3a51A-5iclA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzm | TRYPTOPHAN SYNTHASEALPHA CHAIN (Francisellatularensis) |
PF00290(Trp_syntA) | 5 | ASN A 69ILE A 37THR A 257VAL A 260PRO A 22 | None | 1.20A | 3a51A-5kzmA:undetectable | 3a51A-5kzmA:21.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l94 | CYTOCHROME P450 (Bacillusmegaterium) |
PF00067(p450) | 6 | ILE A 85LYS A 187LEU A 238ILE A 241THR A 246VAL A 289 | HEM A 501 (-4.4A)NoneHEM A 501 (-4.4A)TES A 502 (-4.0A)HEM A 501 (-3.4A)TES A 502 (-4.8A) | 0.43A | 3a51A-5l94A:49.3 | 3a51A-5l94A:34.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mz9 | - (-) |
no annotation | 5 | THR A 70ILE A 388ASN A 73ILE A 309LEU A 552 | None | 1.21A | 3a51A-5mz9A:undetectable | 3a51A-5mz9A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2p | SUGAR ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN (Treponemapallidum) |
PF01547(SBP_bac_1) | 5 | ASN A 392LEU A 217ILE A 384VAL A 237LEU A 201 | NoneNoneNoneNone BR A 501 ( 4.6A) | 1.16A | 3a51A-5u2pA:undetectable | 3a51A-5u2pA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ulv | MALATE DEHYDROGENASE (Methylobacteriumextorquens) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 240ASN A 121ILE A 117VAL A 30LEU A 8 | None | 1.26A | 3a51A-5ulvA:undetectable | 3a51A-5ulvA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5upy | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Listeriamonocytogenes) |
PF00478(IMPDH) | 5 | ILE A 46ASN A 280ILE A 344PRO A 45LEU A 354 | NoneIMP A 500 ( 4.3A)NoneNoneNone | 1.24A | 3a51A-5upyA:undetectable | 3a51A-5upyA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtb | NADH-UBIQUINONEOXIDOREDUCTASE 75KDA SUBUNIT,MITOCHONDRIAL (Homo sapiens) |
PF00384(Molybdopterin)PF09326(NADH_dhqG_C)PF10588(NADH-G_4Fe-4S_3)PF13510(Fer2_4) | 5 | ILE M 418ILE M 391VAL M 475PRO M 407LEU M 516 | None | 1.11A | 3a51A-5xtbM:undetectable | 3a51A-5xtbM:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvm | STEROL3-BETA-GLUCOSYLTRANSFERASE (Saccharomycescerevisiae) |
PF00201(UDPGT)PF03033(Glyco_transf_28) | 5 | THR A 960ILE A1148ILE A1155VAL A 770LEU A 744 | None | 1.15A | 3a51A-5xvmA:undetectable | 3a51A-5xvmA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xzw | SERINE/THREONINE-PROTEIN KINASE RAD53 (Saccharomycescerevisiae) |
no annotation | 5 | ILE A 130LEU A 101THR A 106VAL A 134LEU A 78 | None | 1.24A | 3a51A-5xzwA:undetectable | 3a51A-5xzwA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yj6 | DOCKERIN TYPE IREPEAT-CONTAININGPROTEIN (Ruminiclostridiumthermocellum) |
no annotation | 5 | LYS A 468ASN A 464ILE A 398PRO A 497LEU A 510 | None | 1.19A | 3a51A-5yj6A:undetectable | 3a51A-5yj6A:11.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ysm | CYTOCHROME P450 (Amycolatopsismediterranei) |
no annotation | 5 | ILE A 107LEU A 252ILE A 255THR A 260VAL A 303 | HEM A 501 (-4.2A)HEM A 501 ( 4.6A)NoneHEM A 501 (-3.7A)None | 0.75A | 3a51A-5ysmA:39.7 | 3a51A-5ysmA:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ep3 | - (-) |
no annotation | 5 | ILE A 20ASN A 65LEU A 54ILE A 51LEU A 36 | None | 1.20A | 3a51A-6ep3A:undetectable | 3a51A-6ep3A:undetectable |