SIMILAR PATTERNS OF AMINO ACIDS FOR 3A50_E_VD3E2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ILE A 365
LEU A 424
ASN A 454
LEU A 388
ILE A 385
 None
 1.12A 3a50E-1bk6A:
3.0		 3a50E-1bk6A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 THR A 663
ILE A 495
LEU A 456
ASN A 451
ILE A 515
 None
 1.22A 3a50E-1elvA:
undetectable		 3a50E-1elvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ILE A 432
LEU A 342
ASN A 313
LEU A 441
LEU A 347
 None
 1.20A 3a50E-1ezvA:
0.0		 3a50E-1ezvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2p AMINOPEPTIDASE

(Streptomyces
griseus) 		PF04389
(Peptidase_M28) 		5 PRO A 167
THR A 220
ASN A 255
LEU A 218
THR A 108
 None
 1.23A 3a50E-1f2pA:
undetectable		 3a50E-1f2pA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9n ARGININE
REPRESSOR/ACTIVATOR
PROTEIN

(Bacillus
subtilis) 		PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C) 		5 ILE A 130
LEU A 146
ILE A  87
THR A  98
LEU A  80
 None
 1.22A 3a50E-1f9nA:
0.0		 3a50E-1f9nA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02305
(Phage_F) 		5 THR 1 406
MET 1 404
ILE 1  49
ASN 1 409
ILE 1  66
 None
 1.07A 3a50E-1gff1:
undetectable		 3a50E-1gff1:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		5 LEU A 110
ASN A  68
LEU A  52
ILE A  89
LEU A 119
 None
 1.26A 3a50E-1ghsA:
undetectable		 3a50E-1ghsA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		5 ILE A 485
LEU A  52
ASN A 314
LEU A 489
ILE A 476
 None
 1.25A 3a50E-1gzvA:
undetectable		 3a50E-1gzvA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE

(Zymomonas
mobilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 MET A 342
ILE A 353
ASN A 272
LEU A 340
ILE A 223
 None
 1.28A 3a50E-1h6dA:
undetectable		 3a50E-1h6dA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 THR A 216
ILE A 213
LEU A 240
MET A 236
ILE A 283
 None
 1.26A 3a50E-1hp1A:
undetectable		 3a50E-1hp1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 MET A  92
ILE A  89
LEU A  69
LEU A  95
LEU A 100
 None
 1.28A 3a50E-1igrA:
undetectable		 3a50E-1igrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		5 PRO A 152
ILE A  64
LEU A 125
LEU A 160
THR A 133
 None
 1.08A 3a50E-1jztA:
undetectable		 3a50E-1jztA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 PRO A 325
THR A 324
LEU A 279
ILE A 291
LEU A 285
 None
 1.18A 3a50E-1kfiA:
undetectable		 3a50E-1kfiA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 THR A 185
ILE A 150
LEU A   3
ILE A   2
THR A 200
 None
 1.27A 3a50E-1oi7A:
undetectable		 3a50E-1oi7A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 432
ASN A 422
LEU A 128
ILE A 127
LEU A  40
 None
 1.27A 3a50E-1r3nA:
undetectable		 3a50E-1r3nA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkv HOMOSERINE KINASE

(Pseudomonas
aeruginosa) 		PF12710
(HAD) 		5 ILE A 116
LEU A  55
LEU A  57
ILE A  60
LEU A  47
 None
 1.22A 3a50E-1rkvA:
undetectable		 3a50E-1rkvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus) 		PF00149
(Metallophos) 		5 ILE A 296
LEU A 320
LEU A 292
ILE A 289
LEU A 326
 None
 1.27A 3a50E-1s8eA:
undetectable		 3a50E-1s8eA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 MET A 635
ILE A 632
LEU A 637
THR A 739
LEU A 712
 None
 1.16A 3a50E-1suvA:
undetectable		 3a50E-1suvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 ILE A 259
LEU A 215
ASN A  86
LEU A 244
THR A 103
 None
 1.13A 3a50E-1vmaA:
undetectable		 3a50E-1vmaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 ILE B 365
LEU B 424
ASN B 454
LEU B 388
ILE B 385
 None
 1.11A 3a50E-1wa5B:
3.0		 3a50E-1wa5B:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		5 ILE A 238
LEU A 214
LEU A 243
ILE A 216
THR A 261
 None
 0.94A 3a50E-1xp3A:
undetectable		 3a50E-1xp3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima) 		PF03537
(Glyco_hydro_114) 		5 ILE A 200
LEU A 247
ASN A 206
LEU A 258
ILE A 257
 None
 1.21A 3a50E-2aamA:
undetectable		 3a50E-2aamA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 PRO A  12
THR A  13
ILE A 359
ILE A 390
LEU A1029
 None
 1.22A 3a50E-2b5mA:
undetectable		 3a50E-2b5mA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 LEU A 399
LEU A 345
ILE A 363
THR A 368
LEU A 392
 None
 1.21A 3a50E-2b8nA:
undetectable		 3a50E-2b8nA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		5 ILE A 261
LEU A 239
ASN A 196
LEU A 280
ILE A 242
 None
 1.25A 3a50E-2grmA:
3.0		 3a50E-2grmA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti) 		PF00285
(Citrate_synt) 		5 MET A 381
ILE A 377
LEU A 231
ASN A 200
LEU A 233
 None
 1.10A 3a50E-2h12A:
undetectable		 3a50E-2h12A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwo MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 THR A1876
MET A1837
ILE A1912
LEU A1845
ILE A1847
 None
 1.28A 3a50E-2iwoA:
undetectable		 3a50E-2iwoA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ke5 RAS-RELATED PROTEIN
RAL-B

(Homo sapiens) 		PF00071
(Ras) 		5 THR A  31
ASN A 128
LEU A  67
ILE A  18
LEU A  72
 None
GNP  A 500 (-4.7A)
None
None
None
 1.24A 3a50E-2ke5A:
undetectable		 3a50E-2ke5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opg MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 PRO A1701
THR A1700
ILE A1683
LEU A1706
ILE A1677
 None
 1.14A 3a50E-2opgA:
undetectable		 3a50E-2opgA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		5 MET A 174
ILE A 171
LEU A 179
ILE A 182
LEU A 106
 None
 1.06A 3a50E-2quqA:
undetectable		 3a50E-2quqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7v PROBABLE
ENDONUCLEASE 4

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		5 LEU A 143
ASN A 145
LEU A 106
ILE A 141
LEU A  76
 None
 1.25A 3a50E-2x7vA:
undetectable		 3a50E-2x7vA:
19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		6 MET A  74
ILE A  76
LEU A 159
LEU A 226
ILE A 229
THR A 234
 PG4  A1399 ( 4.4A)
HEM  A1400 (-4.1A)
None
HEM  A1400 (-4.4A)
PG4  A1399 ( 4.5A)
HEM  A1400 (-3.7A)
 0.82A 3a50E-2xkrA:
45.1		 3a50E-2xkrA:
35.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbm PROTEIN-TYROSINE-PHO
SPHATASE

(Shewanella sp.) 		PF00149
(Metallophos) 		5 THR A  53
ILE A 187
ASN A 101
ILE A  59
LEU A 145
 None
 1.23A 3a50E-2zbmA:
undetectable		 3a50E-2zbmA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		6 ILE A  96
LEU A 180
ASN A 194
LEU A 240
ILE A 243
THR A 248
 HEM  A 413 (-4.0A)
VDX  A 501 (-4.2A)
None
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.2A)
 1.37A 3a50E-2zbzA:
47.7		 3a50E-2zbzA:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		5 PRO A 242
THR A  46
LEU A  76
ILE A 119
LEU A 126
 None
 1.24A 3a50E-2zieA:
undetectable		 3a50E-2zieA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aal PROBABLE
ENDONUCLEASE 4

(Geobacillus
kaustophilus) 		PF01261
(AP_endonuc_2) 		5 ILE A 237
LEU A 213
LEU A 242
ILE A 215
THR A 260
 None
 0.96A 3a50E-3aalA:
undetectable		 3a50E-3aalA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 THR C  75
ILE C  25
LEU C  18
ILE C  14
LEU C  34
 None
 1.10A 3a50E-3aizC:
undetectable		 3a50E-3aizC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2

(Thermotoga
maritima;
synthetic
construct) 		PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln) 		5 THR C 562
LEU C 572
LEU C 565
ILE C 569
LEU C 581
 U  E  35 ( 4.6A)
None
C  E  34 ( 3.9A)
None
None
 1.18A 3a50E-3al0C:
undetectable		 3a50E-3al0C:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		5 PRO A 133
MET A 204
ILE A 199
LEU A 160
LEU A 192
 None
 1.26A 3a50E-3csgA:
undetectable		 3a50E-3csgA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 18 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 23 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF04099
(Sybindin) 		5 THR A 124
ILE A 143
LEU C  51
LEU C  58
ILE C  54
 None
 1.24A 3a50E-3cueA:
undetectable		 3a50E-3cueA:
17.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME

(Bacillus
subtilis) 		PF00067
(p450) 		6 MET B  79
LEU B 164
ASN B 181
LEU B 230
ILE B 233
THR B 238
 None
None
None
HEM  B 405 ( 4.6A)
None
HEM  B 405 (-3.7A)
 0.72A 3a50E-3ejbB:
47.3		 3a50E-3ejbB:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi9 MALATE DEHYDROGENASE

(Porphyromonas
gingivalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 PRO A 126
ILE A 321
LEU A 308
LEU A 132
ILE A 271
 None
 1.16A 3a50E-3fi9A:
undetectable		 3a50E-3fi9A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz4 PUTATIVE ARSENATE
REDUCTASE

(Streptococcus
mutans) 		PF03960
(ArsC) 		5 ILE A  92
LEU A  51
LEU A  96
ILE A 103
LEU A  46
 None
None
None
FMT  A 205 (-4.6A)
None
 1.04A 3a50E-3fz4A:
undetectable		 3a50E-3fz4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		5 PRO A 186
ILE A 223
LEU A 196
LEU A 164
ILE A  75
 None
 1.10A 3a50E-3h0lA:
undetectable		 3a50E-3h0lA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR

(Chromobacterium
violaceum) 		PF13377
(Peripla_BP_3) 		6 THR A 133
MET A 155
ILE A 305
LEU A  89
ASN A 107
ILE A  92
 None
None
None
None
SO4  A   1 (-3.2A)
None
 1.31A 3a50E-3h5oA:
undetectable		 3a50E-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Burkholderia
mallei) 		PF00551
(Formyl_trans_N) 		5 MET A 122
ILE A 124
LEU A 268
ILE A 175
LEU A 108
 None
 1.25A 3a50E-3louA:
undetectable		 3a50E-3louA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nro LMO1026 PROTEIN

(Listeria
monocytogenes) 		PF03816
(LytR_cpsA_psr) 		5 ILE A 228
LEU A 166
ILE A 158
THR A 254
LEU A  77
 None
 1.18A 3a50E-3nroA:
undetectable		 3a50E-3nroA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyw PUTATIVE
OXIDOREDUCTASE

(Bacteroides
thetaiotaomicron) 		PF00106
(adh_short) 		5 ILE A  35
LEU A   7
LEU A  62
THR A 125
LEU A  89
 None
 1.21A 3a50E-3nywA:
undetectable		 3a50E-3nywA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE

(Salmonella
enterica) 		PF00285
(Citrate_synt) 		5 PRO A 106
MET A 110
ILE A 227
LEU A 345
ILE A 348
 None
 1.22A 3a50E-3o8jA:
undetectable		 3a50E-3o8jA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8j 2-METHYLCITRATE
SYNTHASE

(Salmonella
enterica) 		PF00285
(Citrate_synt) 		6 PRO A 106
MET A 110
LEU A 345
LEU A 143
ILE A 348
THR A 352
 None
 1.44A 3a50E-3o8jA:
undetectable		 3a50E-3o8jA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		5 PRO A 529
LEU A 545
LEU A 539
ILE A 542
THR A 599
 None
 1.19A 3a50E-3opbA:
2.1		 3a50E-3opbA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		5 ILE A 286
LEU A 297
LEU A 288
ILE A 293
LEU A 299
 None
 1.26A 3a50E-3r7wA:
undetectable		 3a50E-3r7wA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8x METHIONYL-TRNA
FORMYLTRANSFERASE

(Yersinia pestis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 PRO A 103
ILE A 108
ASN A  82
LEU A 187
LEU A  23
 None
 1.11A 3a50E-3r8xA:
undetectable		 3a50E-3r8xA:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		5 LEU A 180
LEU A 252
ILE A 255
THR A 260
LEU A 184
 None
HEM  A 501 ( 4.5A)
D12  A 509 ( 4.1A)
HEM  A 501 (-3.4A)
D12  A 509 ( 4.3A)
 0.92A 3a50E-3r9bA:
49.0		 3a50E-3r9bA:
39.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 PRO A 307
ILE A 315
LEU A 319
ILE A 322
LEU A 510
 None
 1.10A 3a50E-3sqgA:
undetectable		 3a50E-3sqgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		5 LEU A  88
ASN A  81
LEU A  97
ILE A  94
THR A  10
 None
 1.24A 3a50E-3sqnA:
1.5		 3a50E-3sqnA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7b ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00331
(Glyco_hydro_10) 		5 THR A 320
ILE A 269
LYS A  14
LEU A 246
LEU A 231
 None
 1.25A 3a50E-3u7bA:
undetectable		 3a50E-3u7bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3unv ADMH

(Pantoea
agglomerans) 		PF00221
(Lyase_aromatic) 		5 THR A 430
ILE A 527
ASN A 390
THR A 510
LEU A 535
 None
 1.27A 3a50E-3unvA:
2.4		 3a50E-3unvA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae) 		PF00079
(Serpin) 		5 ILE A  58
ASN A 375
ILE A  63
THR A  76
LEU A  84
 None
 1.18A 3a50E-3vvjA:
undetectable		 3a50E-3vvjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqs E3 UBIQUITIN-PROTEIN
LIGASE FANCL

(Homo sapiens) 		PF09765
(WD-3) 		5 PRO A 159
ILE A 186
LEU A 152
ILE A 136
LEU A 121
 None
 1.10A 3a50E-3zqsA:
undetectable		 3a50E-3zqsA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azc BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 LEU A 887
LEU A 868
ILE A 869
THR A 897
LEU A 931
 None
None
None
MG  A2045 (-4.7A)
None
 1.25A 3a50E-4azcA:
undetectable		 3a50E-4azcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1

(Bos taurus) 		PF04916
(Phospholip_B) 		5 ILE B 254
LEU A 102
ASN A  55
ILE A  81
LEU A 169
 None
 1.14A 3a50E-4bwcB:
undetectable		 3a50E-4bwcB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE

(Lachnoclostridium
phytofermentans) 		PF00171
(Aldedh) 		5 THR A 327
MET A 331
ILE A 332
ASN A 265
LEU A 353
 None
 1.27A 3a50E-4c3sA:
undetectable		 3a50E-4c3sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjg HYPOTHETICAL PROTEIN

(Actinomyces
odontolyticus) 		PF16145
(DUF4853) 		5 PRO A  62
ILE A 155
LEU A 138
LEU A 107
ILE A 136
 None
 1.26A 3a50E-4mjgA:
undetectable		 3a50E-4mjgA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN

(Sebaldella
termitidis) 		PF00977
(His_biosynth) 		5 THR A 250
ILE A 218
LEU A 255
ASN A 253
ILE A 239
 None
None
None
EDO  A 309 (-3.3A)
None
 1.25A 3a50E-4ml9A:
undetectable		 3a50E-4ml9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II

(Yersinia pestis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 ILE A 295
LEU A 379
LEU A 299
ILE A 408
THR A 419
 None
 1.21A 3a50E-4pv4A:
undetectable		 3a50E-4pv4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		5 ILE A 168
ASN A 527
MET A 529
LEU A 175
ILE A 174
 None
 1.16A 3a50E-4r3uA:
undetectable		 3a50E-4r3uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ILE A 216
LEU A 185
ASN A 162
LEU A 195
LEU A 231
 None
 1.07A 3a50E-4r5cA:
undetectable		 3a50E-4r5cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I

(synthetic
construct) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		5 ILE A 144
LEU A 113
ASN A  90
LEU A 123
LEU A 161
 None
 1.20A 3a50E-4r6fA:
undetectable		 3a50E-4r6fA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE

(Bacillus
anthracis) 		PF03009
(GDPD) 		5 ILE A 139
LEU A 166
LEU A  71
ILE A 151
LEU A 175
 None
 1.23A 3a50E-4r7oA:
undetectable		 3a50E-4r7oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8p E3 UBIQUITIN-PROTEIN
LIGASE RING2,
UBIQUITIN-CONJUGATIN
G ENZYME E2 D3

(Homo sapiens) 		PF00179
(UQ_con)
PF13923
(zf-C3HC4_2) 		5 PRO L 265
ILE L 288
LEU L 303
LEU L 286
ILE L 306
 None
 1.21A 3a50E-4r8pL:
undetectable		 3a50E-4r8pL:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens) 		no annotation 5 THR C 218
ILE C 248
ASN C 185
ILE C 228
LEU C 269
 None
 0.87A 3a50E-4rwtC:
undetectable		 3a50E-4rwtC:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 ILE A 123
LEU A  78
LEU A 101
ILE A  82
LEU A  92
 None
 1.26A 3a50E-4x2rA:
undetectable		 3a50E-4x2rA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfv VIOF

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N) 		5 ILE A  72
ASN A  98
LEU A 166
ILE A 169
LEU A  89
 None
 1.25A 3a50E-4yfvA:
undetectable		 3a50E-4yfvA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)

(Homo sapiens) 		no annotation 5 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
 None
None
GOL  A 505 (-4.2A)
None
None
 0.87A 3a50E-4z79A:
undetectable		 3a50E-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)

(Homo sapiens) 		no annotation 5 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
 None
None
NI  A 509 (-4.0A)
None
None
 0.77A 3a50E-4z8gA:
undetectable		 3a50E-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		5 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
 None
 0.87A 3a50E-4z94G:
undetectable		 3a50E-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 THR A1741
ILE A1774
LEU A1667
ASN A1725
ILE A1759
 None
 1.28A 3a50E-5a22A:
2.7		 3a50E-5a22A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az3 ABC-TYPE
TRANSPORTER,
PERIPLASMIC
COMPONENT

(Corynebacterium
glutamicum) 		PF01497
(Peripla_BP_2) 		5 THR A 138
ILE A 162
LEU A 143
ILE A 148
THR A 178
 None
 1.27A 3a50E-5az3A:
undetectable		 3a50E-5az3A:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		5 THR A  85
ILE A  89
LEU A 147
ILE A 112
LEU A 119
 None
 1.16A 3a50E-5b83A:
undetectable		 3a50E-5b83A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		5 MET A 111
LEU B  61
LEU A 107
ILE A  47
LEU B  96
 None
 1.23A 3a50E-5c5bA:
undetectable		 3a50E-5c5bA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 ILE A 103
LEU A 204
LEU A 184
ILE A 199
THR A 429
 None
 1.22A 3a50E-5ey8A:
undetectable		 3a50E-5ey8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1

(Homo sapiens) 		PF03587
(EMG1) 		5 ILE A 118
ASN A  65
LEU A 140
THR A 124
LEU A  92
 None
UNX  A 304 ( 4.1A)
None
None
None
 1.11A 3a50E-5faiA:
undetectable		 3a50E-5faiA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fb8 PRO-INTERLEUKIN-16

(Homo sapiens) 		PF00595
(PDZ) 		5 THR C  88
ILE C  82
LEU C 105
ILE C 102
LEU C  35
 None
 1.23A 3a50E-5fb8C:
undetectable		 3a50E-5fb8C:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 PRO A  12
THR A  13
ILE A 359
ILE A 390
LEU A1029
 None
 1.27A 3a50E-5fqdA:
undetectable		 3a50E-5fqdA:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		7 PRO A  83
THR A  84
MET A  86
ILE A  88
LEU A 232
ILE A 235
THR A 240
 None
None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.7A)
 0.44A 3a50E-5gnmA:
56.5		 3a50E-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		5 PRO A  83
THR A  84
MET A  86
ILE A  88
LEU A 387
 None
None
None
HEM  A 501 ( 4.4A)
None
 0.87A 3a50E-5gnmA:
56.5		 3a50E-5gnmA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE

(Saccharomyces
cerevisiae) 		PF04752
(ChaC) 		5 ILE A  17
ASN A 131
LEU A 204
ILE A  93
LEU A  11
 None
 1.26A 3a50E-5hwiA:
undetectable		 3a50E-5hwiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		5 THR A 191
LEU A 231
ASN A 207
LEU A 178
THR A 244
 None
 1.12A 3a50E-5j44A:
undetectable		 3a50E-5j44A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jen ANTI-SIGMA-V FACTOR
RSIV

(Bacillus
subtilis) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		5 PRO A  99
THR A  98
ILE A 162
ASN A 114
LEU A 124
 None
 0.86A 3a50E-5jenA:
undetectable		 3a50E-5jenA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		5 ILE A 259
ASN A  83
LEU A 700
ILE A 703
LEU A  79
 None
 1.18A 3a50E-5jwfA:
undetectable		 3a50E-5jwfA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 PRO B 751
LEU B 782
LEU B 735
ILE B 731
THR B 383
 None
 1.07A 3a50E-5khnB:
undetectable		 3a50E-5khnB:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l94 CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		5 ILE A  85
LYS A 187
LEU A 238
ILE A 241
THR A 246
 HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.4A)
 0.37A 3a50E-5l94A:
49.7		 3a50E-5l94A:
34.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1m MATRIX PROTEIN 1

(Influenza C
virus) 		PF03026
(CM1) 		5 ILE A  29
LEU A  48
ILE A  43
THR A  57
LEU A  14
 None
 1.26A 3a50E-5m1mA:
undetectable		 3a50E-5m1mA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN5

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		5 THR P 304
LEU P 268
ASN P 278
LEU P 299
LEU P 270
 None
 1.28A 3a50E-5mpdP:
undetectable		 3a50E-5mpdP:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5the UNCHARACTERIZED
PROTEIN

(Vanderwaltozyma
polyspora) 		no annotation 5 ILE A 786
LEU A 877
LEU A 905
ILE A 908
LEU A 879
 None
 1.26A 3a50E-5theA:
undetectable		 3a50E-5theA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 5 THR A 678
ILE A 510
LEU A 471
ASN A 466
ILE A 530
 None
 1.24A 3a50E-5ubmA:
undetectable		 3a50E-5ubmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whg PROTEIN VMS1

(Saccharomyces
cerevisiae) 		no annotation 5 PRO A 377
ILE A 343
LEU A 320
ILE A 353
THR A 358
 None
 1.21A 3a50E-5whgA:
undetectable		 3a50E-5whgA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlh LBACAS13A H328A
(C2C2)

(Lachnospiraceae
bacterium
NK4A179) 		no annotation 5 ILE A 560
LYS A 530
ASN A 545
LEU A 592
LEU A 579
 None
 1.26A 3a50E-5wlhA:
undetectable		 3a50E-5wlhA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM
V-TYPE PROTON ATPASE
SUBUNIT F

(Saccharomyces
cerevisiae) 		no annotation 5 PRO O  45
ILE A 755
LEU O  30
ASN O  34
LEU O  24
 None
 1.06A 3a50E-6c6lO:
undetectable		 3a50E-6c6lO:
12.15