SIMILAR PATTERNS OF AMINO ACIDS FOR 3A50_D_VD3D2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)


(Escherichia
coli)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 ILE A  26
LEU A  22
ILE A 126
ALA A 127
THR A  33
None
1.09A 3a50D-1cliA:
undetectable
3a50D-1cliA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE


(Escherichia
coli)
PF00343
(Phosphorylase)
5 MET A 726
ILE A 730
LEU A 727
LEU A 549
LEU A 703
None
1.02A 3a50D-1e4oA:
0.0
3a50D-1e4oA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnw GLUTATHIONE
S-TRANSFERASE


(Arabidopsis
thaliana)
PF00043
(GST_C)
PF02798
(GST_N)
5 PRO A  55
LEU A  21
ILE A  74
ALA A  75
LEU A 170
GTX  A 212 (-4.6A)
None
None
None
None
1.10A 3a50D-1gnwA:
2.6
3a50D-1gnwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays)
PF01593
(Amino_oxidase)
5 LEU A 212
LEU A 445
ASN A  70
ILE A 448
ALA A 451
None
1.07A 3a50D-1h81A:
undetectable
3a50D-1h81A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE


(Trypanosoma
brucei)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
5 ILE A 195
MET A 382
ILE A 338
ALA A 336
LEU A 229
None
1.14A 3a50D-1pgjA:
0.0
3a50D-1pgjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)


(Escherichia
coli)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 PRO A 238
ILE A 120
LEU A 169
ILE A 417
ALA A 416
None
1.12A 3a50D-1qgdA:
undetectable
3a50D-1qgdA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE


(Enterococcus
faecium)
PF01427
(Peptidase_M15)
5 MET A 170
LEU A 166
LEU A  66
ILE A 122
ALA A 121
None
1.02A 3a50D-1r44A:
undetectable
3a50D-1r44A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE


(Escherichia
coli)
PF00465
(Fe-ADH)
5 ILE A 202
LEU A 285
LEU A 229
ILE A 225
ALA A 221
None
1.00A 3a50D-1rrmA:
undetectable
3a50D-1rrmA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh2 RNA POLYMERASE

(Norwalk virus)
PF00680
(RdRP_1)
5 ILE A 215
LEU A 213
ILE A 261
ALA A 258
LEU A 202
None
1.07A 3a50D-1sh2A:
0.0
3a50D-1sh2A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli)
PF00291
(PALP)
PF14821
(Thr_synth_N)
5 PRO A  36
MET A   1
ILE A  63
LEU A 219
ILE A 216
None
1.01A 3a50D-1vb3A:
undetectable
3a50D-1vb3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi4 REGULATOR OF
RIBONUCLEASE
ACTIVITY A PROTEIN 1


(Vibrio cholerae)
PF03737
(RraA-like)
5 MET A 154
ILE A 152
LEU A 145
LEU A 132
ASN A 129
None
1.13A 3a50D-1vi4A:
undetectable
3a50D-1vi4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzq PROBABLE TRNA
MODIFICATION GTPASE
TRME


(Thermotoga
maritima)
PF01926
(MMR_HSR1)
PF10396
(TrmE_N)
PF12631
(MnmE_helical)
5 ILE A 367
LEU A 296
LEU A 232
ILE A 254
LEU A 360
None
1.08A 3a50D-1xzqA:
undetectable
3a50D-1xzqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A


(Homo sapiens)
PF00233
(PDEase_I)
5 LEU A 189
LEU A 244
MET A 310
ILE A 247
THR A 221
None
1.05A 3a50D-1zklA:
undetectable
3a50D-1zklA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
6 PRO A 700
ILE A1428
LEU A1420
LEU A1385
ILE A1387
LEU A1442
None
1.42A 3a50D-2b39A:
undetectable
3a50D-2b39A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana)
PF00696
(AA_kinase)
5 ILE A 129
LEU A 135
ILE A  91
ALA A  88
LEU A 122
None
1.10A 3a50D-2cdqA:
undetectable
3a50D-2cdqA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE


(Halothiobacillus
neapolitanus)
PF08936
(CsoSCA)
5 PRO A 307
ILE A 238
LEU A 291
LEU A 372
ILE A 302
None
1.10A 3a50D-2fgyA:
undetectable
3a50D-2fgyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivg CYANATE LYASE

(Escherichia
coli)
PF02560
(Cyanate_lyase)
5 LEU A  48
ILE A  32
ALA A  33
THR A  36
LEU A  53
None
1.09A 3a50D-2ivgA:
undetectable
3a50D-2ivgA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2le0 POLY [ADP-RIBOSE]
POLYMERASE 1


(Rattus
norvegicus)
PF00533
(BRCT)
5 PRO A   3
MET A   7
ILE A   9
LEU A   4
LEU A  87
None
1.07A 3a50D-2le0A:
undetectable
3a50D-2le0A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM


(Homo sapiens)
PF02985
(HEAT)
PF13646
(HEAT_2)
5 ASN A  22
ILE A  38
ALA A  39
THR A  47
LEU A  55
None
1.09A 3a50D-2pkgA:
undetectable
3a50D-2pkgA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica)
PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3)
5 ILE A 191
LEU A 211
LEU A 203
ILE A 180
ALA A 179
None
1.08A 3a50D-2uvfA:
undetectable
3a50D-2uvfA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Bacillus
subtilis)
PF01979
(Amidohydro_1)
5 PRO A  39
LEU A   6
ILE A  31
ALA A 366
LEU A  55
None
1.07A 3a50D-2vhlA:
undetectable
3a50D-2vhlA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vx4 CELLVIBRIO JAPONICUS
MANNANASE CJMAN26C


(Cellvibrio
japonicus)
PF02156
(Glyco_hydro_26)
5 PRO A 265
ILE A 291
LEU A 320
ILE A 367
ALA A 368
None
1.12A 3a50D-2vx4A:
undetectable
3a50D-2vx4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ


(Bacillus
subtilis)
PF00091
(Tubulin)
PF12327
(FtsZ_C)
5 PRO A 165
MET A 226
ILE A 228
LEU A 249
LEU A 190
None
1.13A 3a50D-2vxyA:
undetectable
3a50D-2vxyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whk MANNAN
ENDO-1,4-BETA-MANNOS
IDASE


(Bacillus
subtilis)
PF02156
(Glyco_hydro_26)
5 PRO A 159
ILE A  63
ILE A 236
ALA A 263
THR A 292
None
1.13A 3a50D-2whkA:
undetectable
3a50D-2whkA:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 MET A  74
ILE A  76
LEU A 159
ILE A 229
THR A 234
PG4  A1399 ( 4.4A)
HEM  A1400 (-4.1A)
None
PG4  A1399 ( 4.5A)
HEM  A1400 (-3.7A)
0.86A 3a50D-2xkrA:
45.0
3a50D-2xkrA:
35.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE


(Burkholderia
cenocepacia)
PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2)
5 PRO A 182
ILE A 235
LEU A 211
LEU A 186
ILE A 215
None
1.08A 3a50D-2y4oA:
undetectable
3a50D-2y4oA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn7 OUTER SURFACE
PROTEIN


(Borreliella
burgdorferi)
PF05714
(Borrelia_lipo_1)
5 MET A 285
ILE A 284
LEU A 288
LEU A 393
ALA A 365
None
1.04A 3a50D-2yn7A:
undetectable
3a50D-2yn7A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus)
PF01979
(Amidohydro_1)
5 ILE A   2
LEU A   3
ILE A  28
ALA A 376
LEU A  47
None
0.95A 3a50D-2z00A:
undetectable
3a50D-2z00A:
24.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus)
PF00067
(p450)
6 ILE A  96
LEU A 180
ASN A 194
ILE A 243
ALA A 244
THR A 248
HEM  A 413 (-4.0A)
VDX  A 501 (-4.2A)
None
VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
1.43A 3a50D-2zbzA:
47.7
3a50D-2zbzA:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl5 58 KD CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
6 PRO A 317
ILE A 299
LEU A 301
ASN A 267
ILE A 330
THR A 341
None
1.40A 3a50D-2zl5A:
undetectable
3a50D-2zl5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm2 6-AMINOHEXANOATE-DIM
ER HYDROLASE


(Flavobacterium
sp.)
PF00144
(Beta-lactamase)
5 ILE A  66
LEU A  73
LEU A 382
ILE A 360
THR A 356
None
1.09A 3a50D-2zm2A:
undetectable
3a50D-2zm2A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3can PYRUVATE-FORMATE
LYASE-ACTIVATING
ENZYME


(Bacteroides
vulgatus)
PF04055
(Radical_SAM)
5 ILE A 173
ASN A  81
ILE A 132
ALA A 181
LEU A 104
None
1.11A 3a50D-3canA:
undetectable
3a50D-3canA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjp PREDICTED
AMIDOHYDROLASE,
DIHYDROOROTASE
FAMILY


(Clostridium
acetobutylicum)
PF04909
(Amidohydro_2)
5 PRO A 124
ILE A 160
LEU A 155
LEU A 166
LEU A 198
None
1.04A 3a50D-3cjpA:
undetectable
3a50D-3cjpA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgt ENDO-1,3-BETA-GLUCAN
ASE


(Streptomyces
sioyaensis)
PF00722
(Glyco_hydro_16)
5 MET A 159
ILE A 206
LEU A 143
ASN A 136
ALA A 220
None
1.06A 3a50D-3dgtA:
undetectable
3a50D-3dgtA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm9 SIGNAL RECOGNITION
PARTICLE RECEPTOR


(Pyrococcus
furiosus)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 ILE B 140
LEU B 210
LEU B 293
THR B 270
LEU B 304
None
0.94A 3a50D-3dm9B:
undetectable
3a50D-3dm9B:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME


(Bacillus
subtilis)
PF00067
(p450)
6 MET B  79
LEU B 164
ASN B 181
ILE B 233
ALA B 234
THR B 238
None
None
None
None
HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
0.81A 3a50D-3ejbB:
47.5
3a50D-3ejbB:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoi PILM

(Escherichia
coli)
PF07419
(PilM)
5 LEU A  77
ILE A 120
ALA A  92
THR A 102
LEU A  82
None
1.11A 3a50D-3eoiA:
undetectable
3a50D-3eoiA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goz LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN


(Legionella
pneumophila)
no annotation 5 LEU A  92
LEU A  85
ASN A  57
ILE A 107
LEU A 143
None
1.07A 3a50D-3gozA:
undetectable
3a50D-3gozA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hb0 EYES ABSENT HOMOLOG
2 (DROSOPHILA)


(Homo sapiens)
PF00702
(Hydrolase)
5 ILE A 280
LEU A 425
ASN A 396
THR A 449
LEU A 445
None
1.04A 3a50D-3hb0A:
undetectable
3a50D-3hb0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lki FRUCTOKINASE

(Xylella
fastidiosa)
PF00294
(PfkB)
5 ILE A 300
LEU A 304
LEU A 235
ALA A 251
THR A 250
None
0.98A 3a50D-3lkiA:
undetectable
3a50D-3lkiA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzm DNA POLYMERASE III
SUBUNIT ALPHA


(Synechocystis
sp. PCC 6803)
no annotation 5 ILE A  66
LEU A  60
LEU A  95
ILE A 156
ALA A 157
None
1.08A 3a50D-3nzmA:
undetectable
3a50D-3nzmA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 MET A 190
ILE A 214
LEU A 212
ALA A 221
LEU A 231
None
0.93A 3a50D-3o6nA:
undetectable
3a50D-3o6nA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1


(Anopheles
gambiae)
PF13855
(LRR_8)
5 MET B 190
ILE B 214
LEU B 212
ALA B 221
LEU B 231
None
0.93A 3a50D-3ojaB:
undetectable
3a50D-3ojaB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1


(Homo sapiens)
PF09735
(Nckap1)
5 PRO B 188
ILE B 267
LEU B 189
ILE B 138
LEU B 293
None
0.96A 3a50D-3p8cB:
1.5
3a50D-3p8cB:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes)
PF01212
(Beta_elim_lyase)
5 ILE A 183
LEU A 153
LEU A 197
ALA A 191
LEU A 175
None
1.09A 3a50D-3pj0A:
undetectable
3a50D-3pj0A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pty ARABINOSYLTRANSFERAS
E C


(Mycobacterium
tuberculosis)
PF14896
(Arabino_trans_C)
5 PRO A1007
LEU A1063
LEU A 983
ILE A1011
ALA A1059
None
1.10A 3a50D-3ptyA:
undetectable
3a50D-3ptyA:
25.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9b CYTOCHROME P450
164A2


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 LEU A 180
ILE A 255
ALA A 256
THR A 260
LEU A 184
None
D12  A 509 ( 4.1A)
HEM  A 501 ( 3.5A)
HEM  A 501 (-3.4A)
D12  A 509 ( 4.3A)
0.83A 3a50D-3r9bA:
48.9
3a50D-3r9bA:
39.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo)
PF00082
(Peptidase_S8)
5 PRO A 454
ILE A 394
LEU A 361
THR A 336
LEU A 436
None
1.13A 3a50D-3vtaA:
undetectable
3a50D-3vtaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyn LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B


(Mus musculus)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 ILE A 246
LEU A 243
LEU A 236
ASN A 215
LEU A 284
None
0.99A 3a50D-3zynA:
undetectable
3a50D-3zynA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli)
PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
5 ILE A 526
LEU A 564
ASN A 723
MET A 647
ALA A  63
None
None
A  B  14 ( 3.4A)
None
None
1.13A 3a50D-4arcA:
undetectable
3a50D-4arcA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1


(Bos taurus)
PF04916
(Phospholip_B)
5 ILE B 254
LEU A 102
ASN A  55
ILE A  81
LEU A 169
None
1.07A 3a50D-4bwcB:
undetectable
3a50D-4bwcB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
PROTEIN CAF40


(Saccharomyces
cerevisiae)
PF04078
(Rcd1)
PF12842
(DUF3819)
5 LEU B 203
ILE A1114
ALA A1115
THR A1119
LEU B 153
None
0.98A 3a50D-4cv5B:
undetectable
3a50D-4cv5B:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhe PROBABLE GTP-BINDING
PROTEIN ENGB


(Burkholderia
thailandensis)
PF01926
(MMR_HSR1)
5 MET A 118
ILE A 116
LEU A 146
ILE A  42
LEU A   5
None
1.14A 3a50D-4dheA:
undetectable
3a50D-4dheA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN


(Bacteroides
eggerthii)
no annotation 5 ILE A 546
LEU A 537
LEU A 530
ALA A 549
LEU A 559
None
1.09A 3a50D-4ecoA:
undetectable
3a50D-4ecoA:
20.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j6c CYTOCHROME P450
MONOOXYGENASE


(Nocardia
farcinica)
PF00067
(p450)
5 ILE A  12
LEU A 396
LEU A 294
ALA A  44
THR A  46
None
FMT  A 504 (-4.4A)
HEM  A 502 ( 4.0A)
None
None
1.04A 3a50D-4j6cA:
46.2
3a50D-4j6cA:
33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyl ENOYL-COA HYDRATASE

(Thermoplasma
volcanium)
PF00378
(ECH_1)
5 MET A  65
LEU A  30
ILE A  25
ALA A  24
LEU A   2
None
1.04A 3a50D-4jylA:
undetectable
3a50D-4jylA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens)
PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2)
5 PRO A 741
MET A 211
LEU A 145
LEU A 154
ALA A 159
None
1.06A 3a50D-4krfA:
undetectable
3a50D-4krfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE


(Coxiella
burnetii)
PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
5 PRO A  97
ILE A 137
LEU A  98
LEU A 131
ILE A 218
None
1.08A 3a50D-4nbqA:
4.3
3a50D-4nbqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN


(synthetic
construct)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 ILE A 325
LEU A 349
LEU A 309
ILE A 305
ALA A 301
None
0.89A 3a50D-4r5dA:
undetectable
3a50D-4r5dA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5d LEUCINE RICH REPEAT
PROTEIN


(synthetic
construct)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 ILE A 382
LEU A 406
LEU A 366
ILE A 362
ALA A 358
None
1.05A 3a50D-4r5dA:
undetectable
3a50D-4r5dA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K


(synthetic
construct)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 ILE A 405
LEU A 429
LEU A 389
ILE A 385
ALA A 381
None
0.92A 3a50D-4r6gA:
undetectable
3a50D-4r6gA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens)
no annotation 5 ILE C 248
ASN C 185
ILE C 228
ALA C 229
LEU C 269
None
0.90A 3a50D-4rwtC:
undetectable
3a50D-4rwtC:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE


(Mycobacterium
tuberculosis)
PF00768
(Peptidase_S11)
5 LEU A 120
LEU A  74
ILE A  71
ALA A  68
THR A 240
None
1.12A 3a50D-4ryeA:
undetectable
3a50D-4ryeA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans)
PF13855
(LRR_8)
5 ILE A  95
LEU A  72
LEU A  87
ILE A  84
LEU A 113
None
1.12A 3a50D-4tzhA:
undetectable
3a50D-4tzhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhk TRANSCRIPTIONAL
REGULATORY PROTEIN
CPXR


(Escherichia
coli)
PF00072
(Response_reg)
5 ILE A   4
LEU A  21
LEU A  98
ASN A 103
ILE A  75
None
1.13A 3a50D-4uhkA:
undetectable
3a50D-4uhkA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj7 MALCAVERNIN

(Homo sapiens)
no annotation 5 ILE A  76
LEU A  80
LEU A  89
ILE A  92
ALA A  95
None
1.14A 3a50D-4wj7A:
undetectable
3a50D-4wj7A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc7 FORMIN-LIKE PROTEIN
2


(Homo sapiens)
PF06367
(Drf_FH3)
PF06371
(Drf_GBD)
5 ILE B 283
MET B 232
ILE B 251
ALA B 252
LEU B 267
None
1.11A 3a50D-4yc7B:
undetectable
3a50D-4yc7B:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx5 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAO


(Salmonella
enterica)
PF01052
(FliMN_C)
no annotation
5 ILE A  61
LEU B  32
ASN B  51
ILE A  16
ALA A  42
None
1.05A 3a50D-4yx5A:
undetectable
3a50D-4yx5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx5 SURFACE PRESENTATION
OF ANTIGENS PROTEIN
SPAO


(Salmonella
enterica)
PF01052
(FliMN_C)
no annotation
5 PRO B  33
ILE A  61
LEU B  32
ILE A  16
ALA A  42
None
1.01A 3a50D-4yx5B:
undetectable
3a50D-4yx5B:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)


(Homo sapiens)
no annotation 5 ILE A 399
ASN A 336
ILE A 379
ALA A 380
LEU A 420
None
GOL  A 505 (-4.2A)
None
GOL  A 502 (-3.6A)
None
0.97A 3a50D-4z79A:
undetectable
3a50D-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)


(Homo sapiens)
no annotation 5 ILE A 399
ASN A 201
ILE A 379
ALA A 380
LEU A 420
None
NI  A 509 (-4.0A)
None
None
None
0.87A 3a50D-4z8gA:
undetectable
3a50D-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
5 ILE G1399
ASN G1201
ILE G1379
ALA G1380
LEU G1420
None
0.96A 3a50D-4z94G:
undetectable
3a50D-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsw 4-COUMARATE--COA
LIGASE 2


(Nicotiana
tabacum)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ILE A 288
LEU A 230
ASN A  86
MET A 258
ILE A 270
None
1.12A 3a50D-5bswA:
undetectable
3a50D-5bswA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
6 LEU A 171
ASN A 181
MET A 184
ILE A 235
ALA A 236
THR A 240
None
None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
1.40A 3a50D-5gnmA:
56.8
3a50D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
6 LEU A 171
LYS A 180
ASN A 181
MET A 184
ALA A 236
THR A 240
None
None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
1.37A 3a50D-5gnmA:
56.8
3a50D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
6 PRO A  83
MET A  86
ILE A  88
LEU A  89
ILE A 235
LEU A 387
None
None
HEM  A 501 ( 4.4A)
None
None
None
0.81A 3a50D-5gnmA:
56.8
3a50D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
6 PRO A  83
MET A  86
ILE A  88
LEU A  89
ILE A 235
THR A 240
None
None
HEM  A 501 ( 4.4A)
None
None
HEM  A 501 (-3.7A)
0.42A 3a50D-5gnmA:
56.8
3a50D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
6 PRO A  83
MET A  86
LEU A  89
ILE A 235
ALA A 236
LEU A 387
None
None
None
None
HEM  A 501 (-3.6A)
None
0.94A 3a50D-5gnmA:
56.8
3a50D-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
6 PRO A  83
MET A  86
LEU A  89
ILE A 235
ALA A 236
THR A 240
None
None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
0.73A 3a50D-5gnmA:
56.8
3a50D-5gnmA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0r VP4 PROTEIN

(Cypovirus 1)
no annotation 5 PRO G   6
ILE G 172
LEU G 154
ILE G  77
ALA G  74
None
1.01A 3a50D-5h0rG:
undetectable
3a50D-5h0rG:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN


(Streptococcus
suis)
PF05833
(FbpA)
5 ILE A  91
LEU A 100
LEU A 257
ALA A  17
LEU A  61
None
1.08A 3a50D-5h3xA:
undetectable
3a50D-5h3xA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6z SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER


(Homo sapiens)
PF00209
(SNF)
5 ILE A 552
LEU A 549
LEU A 337
ILE A 333
ALA A 329
None
1.06A 3a50D-5i6zA:
undetectable
3a50D-5i6zA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3


(Saccharomyces
cerevisiae)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF13656
(RNA_pol_L_2)
5 ILE K  46
LEU K  50
ASN K  29
ILE K  33
LEU C 262
None
1.14A 3a50D-5ip7K:
undetectable
3a50D-5ip7K:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izt OUTER SURFACE
PROTEIN


(Borreliella
burgdorferi)
PF05714
(Borrelia_lipo_1)
5 MET A 285
ILE A 284
LEU A 288
LEU A 393
ALA A 365
None
1.06A 3a50D-5iztA:
undetectable
3a50D-5iztA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6q CELL WALL BINDING
PROTEIN CWP8


(Clostridioides
difficile)
PF04122
(CW_binding_2)
5 ILE A 344
LEU A 535
ASN A 507
ILE A 327
ALA A 326
None
1.08A 3a50D-5j6qA:
undetectable
3a50D-5j6qA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l94 CYTOCHROME P450

(Bacillus
megaterium)
PF00067
(p450)
5 ILE A  85
LYS A 187
ILE A 241
ALA A 242
THR A 246
HEM  A 501 (-4.4A)
None
TES  A 502 (-4.0A)
HEM  A 501 (-3.5A)
HEM  A 501 (-3.4A)
0.44A 3a50D-5l94A:
49.6
3a50D-5l94A:
34.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila)
PF12331
(DUF3636)
5 MET A 559
ILE A 480
LEU A 523
ASN A 572
ALA A 529
None
1.11A 3a50D-5loiA:
2.5
3a50D-5loiA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens)
PF07555
(NAGidase)
5 PRO A 209
ILE A 134
LEU A 171
ALA A  96
LEU A 248
None
1.12A 3a50D-5m7rA:
undetectable
3a50D-5m7rA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzg UDP-GLUCOSE
PYROPHOSPHORYLASE


(Leishmania
major)
no annotation 5 MET A 215
ILE A 312
LEU A 314
ILE A 194
LEU A 328
None
1.12A 3a50D-5nzgA:
undetectable
3a50D-5nzgA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN


(Homo sapiens)
PF07555
(NAGidase)
5 PRO A 209
ILE A 134
LEU A 171
ALA A  96
LEU A 248
None
1.13A 3a50D-5uhkA:
undetectable
3a50D-5uhkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 4


(Homo sapiens)
PF13191
(AAA_16)
PF14629
(ORC4_C)
6 LEU C  99
LEU C 140
ASN C 135
ILE C 187
ALA C 188
THR C  54
None
1.50A 3a50D-5uj7C:
undetectable
3a50D-5uj7C:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY


(Vibrio cholerae)
PF00939
(Na_sulph_symp)
5 ILE A 426
LEU A 183
MET A 438
ALA A 189
THR A 142
None
1.04A 3a50D-5uldA:
undetectable
3a50D-5uldA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viu ACETYLORNITHINE
AMINOTRANSFERASE


(Elizabethkingia
anophelis)
PF00202
(Aminotran_3)
5 ILE A 329
LEU A 332
LEU A 365
ILE A 384
LEU A 374
None
1.02A 3a50D-5viuA:
undetectable
3a50D-5viuA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvo PROTEIN O-GLCNACASE

(Homo sapiens)
PF07555
(NAGidase)
5 PRO A 209
ILE A 134
LEU A 171
ALA A  96
LEU A 248
None
1.10A 3a50D-5vvoA:
undetectable
3a50D-5vvoA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus)
no annotation 5 ILE A 410
LEU A 379
LEU A 369
ALA A 388
LEU A 417
None
1.09A 3a50D-5y3jA:
undetectable
3a50D-5y3jA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9w POLLEN RECEPTOR-LIKE
KINASE 6


(Arabidopsis
thaliana)
no annotation 5 ILE B 135
LEU B 112
LEU B 146
THR B 165
LEU B 173
None
1.08A 3a50D-5y9wB:
undetectable
3a50D-5y9wB:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bii GLYOXYLATE REDUCTASE

(Pyrococcus
yayanosii)
no annotation 5 MET A 230
ILE A 259
LEU A 227
LEU A 210
LEU A 264
None
1.13A 3a50D-6biiA:
undetectable
3a50D-6biiA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD


(Bacillus
thuringiensis)
no annotation 5 PRO A 286
MET A 288
ILE A 290
ILE A 218
ALA A 219
None
1.11A 3a50D-6bwcA:
undetectable
3a50D-6bwcA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM
V-TYPE PROTON ATPASE
SUBUNIT F


(Saccharomyces
cerevisiae)
no annotation 5 PRO O  45
ILE A 755
LEU O  30
ASN O  34
LEU O  24
None
1.03A 3a50D-6c6lO:
undetectable
3a50D-6c6lO:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A


(Mus musculus)
no annotation 5 LEU A 453
LEU A 468
ILE A 465
ALA A 487
LEU A 495
None
1.11A 3a50D-6fnwA:
undetectable
3a50D-6fnwA:
13.10