SIMILAR PATTERNS OF AMINO ACIDS FOR 3A50_C_VD3C2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bk6 KARYOPHERIN ALPHA

(Saccharomyces
cerevisiae)
PF00514
(Arm)
PF16186
(Arm_3)
5 ILE A 365
LEU A 424
ASN A 454
LEU A 388
ILE A 385
None
1.12A 3a50C-1bk6A:
2.9
3a50C-1bk6A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt0 PROTEIN
(UBIQUITIN-LIKE
PROTEIN 7, RUB1)


(Arabidopsis
thaliana)
PF00240
(ubiquitin)
5 THR A   9
ILE A  13
LEU A  71
ILE A  36
LEU A  43
None
1.27A 3a50C-1bt0A:
undetectable
3a50C-1bt0A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cby DELTA-ENDOTOXIN CYTB

(Bacillus
thuringiensis)
PF01338
(Bac_thur_toxin)
5 ILE A  87
LEU A  81
ASN A  76
LEU A 222
ILE A  92
None
1.30A 3a50C-1cbyA:
undetectable
3a50C-1cbyA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei)
PF00840
(Glyco_hydro_7)
5 ILE A 269
LEU A 128
LEU A 209
ILE A 199
LEU A 309
None
1.31A 3a50C-1eg1A:
undetectable
3a50C-1eg1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 THR A 663
ILE A 495
LEU A 456
ASN A 451
ILE A 515
None
1.24A 3a50C-1elvA:
undetectable
3a50C-1elvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evj GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 MET A 290
ILE A 301
ASN A 220
LEU A 288
ILE A 171
None
1.25A 3a50C-1evjA:
undetectable
3a50C-1evjA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9n ARGININE
REPRESSOR/ACTIVATOR
PROTEIN


(Bacillus
subtilis)
PF01316
(Arg_repressor)
PF02863
(Arg_repressor_C)
5 ILE A 130
LEU A 146
ILE A  87
THR A  98
LEU A  80
None
1.24A 3a50C-1f9nA:
undetectable
3a50C-1f9nA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ


(Escherichia
virus G4)
PF02305
(Phage_F)
5 THR 1 406
MET 1 404
ILE 1  49
ASN 1 409
ILE 1  66
None
1.04A 3a50C-1gff1:
undetectable
3a50C-1gff1:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 MET A 342
ILE A 353
ASN A 272
LEU A 340
ILE A 223
None
1.20A 3a50C-1h6dA:
0.0
3a50C-1h6dA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
5 THR A 216
ILE A 213
LEU A 240
MET A 236
ILE A 283
None
1.27A 3a50C-1hp1A:
undetectable
3a50C-1hp1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster)
PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid)
5 THR A 162
ILE A 127
ILE A 203
THR A 274
LEU A 335
None
1.30A 3a50C-1hwwA:
undetectable
3a50C-1hwwA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igr INSULIN-LIKE GROWTH
FACTOR RECEPTOR 1


(Homo sapiens)
PF00757
(Furin-like)
PF01030
(Recep_L_domain)
5 MET A  92
ILE A  89
LEU A  69
LEU A  95
LEU A 100
None
1.29A 3a50C-1igrA:
undetectable
3a50C-1igrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION


(Bacillus
subtilis)
PF01256
(Carb_kinase)
5 THR A 157
MET A 156
LEU A 185
LEU A 132
THR A 219
None
1.28A 3a50C-1kyhA:
undetectable
3a50C-1kyhA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE


(Thermotoga
maritima)
PF00171
(Aldedh)
5 THR A 292
ILE A 275
LEU A 261
ILE A 316
THR A 249
None
1.12A 3a50C-1o20A:
undetectable
3a50C-1o20A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE


(Escherichia
coli)
PF01156
(IU_nuc_hydro)
5 LEU A 121
ASN A 129
LEU A 141
ILE A 144
LEU A 184
None
1.30A 3a50C-1q8fA:
undetectable
3a50C-1q8fA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE


(Lachancea
kluyveri)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ILE A 432
ASN A 422
LEU A 128
ILE A 127
LEU A  40
None
1.22A 3a50C-1r3nA:
undetectable
3a50C-1r3nA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkv HOMOSERINE KINASE

(Pseudomonas
aeruginosa)
PF12710
(HAD)
5 ILE A 116
LEU A  55
LEU A  57
ILE A  60
LEU A  47
None
1.27A 3a50C-1rkvA:
undetectable
3a50C-1rkvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus)
PF00149
(Metallophos)
5 ILE A 296
LEU A 320
LEU A 292
ILE A 289
LEU A 326
None
1.29A 3a50C-1s8eA:
undetectable
3a50C-1s8eA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus)
PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3)
5 ILE B2000
LEU B2013
ASN B1980
ILE B1922
LEU B1872
None
1.26A 3a50C-1sddB:
undetectable
3a50C-1sddB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
5 MET A 635
ILE A 632
LEU A 637
THR A 739
LEU A 712
None
1.21A 3a50C-1suvA:
undetectable
3a50C-1suvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 114
LEU A 143
ASN A  73
LEU A 203
ILE A 202
None
1.15A 3a50C-1ua2A:
undetectable
3a50C-1ua2A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY


(Thermotoga
maritima)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 ILE A 259
LEU A 215
ASN A  86
LEU A 244
THR A 103
None
1.17A 3a50C-1vmaA:
2.4
3a50C-1vmaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY


(Thermotoga
maritima)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 LEU A 215
ASN A  86
LEU A 244
ILE A 243
THR A 103
None
1.19A 3a50C-1vmaA:
2.4
3a50C-1vmaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3)
5 ILE B 365
LEU B 424
ASN B 454
LEU B 388
ILE B 385
None
1.10A 3a50C-1wa5B:
3.0
3a50C-1wa5B:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7f OUTER SURFACE
PROTEIN


(Bacillus cereus)
PF05913
(DUF871)
5 ILE A 163
ASN A 122
LEU A 219
ILE A 220
LEU A 199
None
1.06A 3a50C-1x7fA:
undetectable
3a50C-1x7fA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis)
PF01261
(AP_endonuc_2)
5 ILE A 238
LEU A 214
LEU A 243
ILE A 216
THR A 261
None
1.00A 3a50C-1xp3A:
undetectable
3a50C-1xp3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans)
PF00154
(RecA)
5 THR A  54
ILE A  76
LEU A 273
LEU A 235
ILE A 257
None
1.31A 3a50C-1xp8A:
undetectable
3a50C-1xp8A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT


(Homo sapiens)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 ILE A 713
LEU A 634
ASN A 691
LEU A 696
LEU A 632
None
0.97A 3a50C-1z68A:
undetectable
3a50C-1z68A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE


(Thermotoga
maritima)
PF05161
(MOFRL)
PF13660
(DUF4147)
5 LEU A 399
LEU A 345
ILE A 363
THR A 368
LEU A 392
None
1.24A 3a50C-2b8nA:
undetectable
3a50C-2b8nA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens)
PF13688
(Reprolysin_5)
5 THR A 403
LEU A 227
ASN A 410
LEU A 251
ILE A 279
None
1.20A 3a50C-2fv5A:
undetectable
3a50C-2fv5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h12 CITRATE SYNTHASE

(Acetobacter
aceti)
PF00285
(Citrate_synt)
5 MET A 381
ILE A 377
LEU A 231
ASN A 200
LEU A 233
None
1.13A 3a50C-2h12A:
undetectable
3a50C-2h12A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwo MULTIPLE PDZ DOMAIN
PROTEIN


(Homo sapiens)
PF00595
(PDZ)
5 THR A1876
MET A1837
ILE A1912
LEU A1845
ILE A1847
None
1.27A 3a50C-2iwoA:
undetectable
3a50C-2iwoA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ke5 RAS-RELATED PROTEIN
RAL-B


(Homo sapiens)
PF00071
(Ras)
5 THR A  31
ASN A 128
LEU A  67
ILE A  18
LEU A  72
None
GNP  A 500 (-4.7A)
None
None
None
1.26A 3a50C-2ke5A:
undetectable
3a50C-2ke5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
5 ILE A 111
ASN A 363
LEU A 235
ILE A 232
THR A 171
None
1.20A 3a50C-2np0A:
undetectable
3a50C-2np0A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B


(Saccharomyces
cerevisiae)
PF16846
(Cep3)
5 MET A 174
ILE A 171
LEU A 179
ILE A 182
LEU A 106
None
1.03A 3a50C-2quqA:
undetectable
3a50C-2quqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sfa SERINE PROTEINASE

(Streptomyces
fradiae)
PF00089
(Trypsin)
5 LEU A 135
ASN A  64
LEU A 151
THR A 118
LEU A 120
None
1.20A 3a50C-2sfaA:
undetectable
3a50C-2sfaA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlc POLYSIALIC ACID
O-ACETYLTRANSFERASE


(Neisseria
meningitidis)
PF00132
(Hexapep)
5 THR A  86
MET A  88
ILE A  67
ILE A  93
LEU A  59
None
1.32A 3a50C-2wlcA:
undetectable
3a50C-2wlcA:
16.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 ILE A  76
LEU A 159
LEU A 226
ILE A 229
THR A 234
HEM  A1400 (-4.1A)
None
HEM  A1400 (-4.4A)
PG4  A1399 ( 4.5A)
HEM  A1400 (-3.7A)
0.76A 3a50C-2xkrA:
44.9
3a50C-2xkrA:
35.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
5 MET A  74
ILE A  76
LEU A 159
LEU A 226
THR A 234
PG4  A1399 ( 4.4A)
HEM  A1400 (-4.1A)
None
HEM  A1400 (-4.4A)
HEM  A1400 (-3.7A)
0.73A 3a50C-2xkrA:
44.9
3a50C-2xkrA:
35.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus)
PF00067
(p450)
5 ILE A  96
LEU A 180
LEU A 240
ILE A 243
THR A 248
HEM  A 413 (-4.0A)
VDX  A 501 (-4.2A)
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.2A)
0.66A 3a50C-2zbzA:
47.8
3a50C-2zbzA:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aal PROBABLE
ENDONUCLEASE 4


(Geobacillus
kaustophilus)
PF01261
(AP_endonuc_2)
5 ILE A 237
LEU A 213
LEU A 242
ILE A 215
THR A 260
None
1.03A 3a50C-3aalA:
undetectable
3a50C-3aalA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C


(Sulfurisphaera
tokodaii)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 THR C  75
ILE C  25
LEU C  18
ILE C  14
LEU C  34
None
1.12A 3a50C-3aizC:
undetectable
3a50C-3aizC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2


(Thermotoga
maritima;
synthetic
construct)
PF00749
(tRNA-synt_1c)
PF02686
(Glu-tRNAGln)
5 THR C 562
LEU C 572
LEU C 565
ILE C 569
LEU C 581
U  E  35 ( 4.6A)
None
C  E  34 ( 3.9A)
None
None
1.21A 3a50C-3al0C:
undetectable
3a50C-3al0C:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 18 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 23 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF04099
(Sybindin)
5 THR A 124
ILE A 143
LEU C  51
LEU C  58
ILE C  54
None
1.25A 3a50C-3cueA:
undetectable
3a50C-3cueA:
17.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME


(Bacillus
subtilis)
PF00067
(p450)
6 MET B  79
LEU B 164
ASN B 181
LEU B 230
ILE B 233
THR B 238
None
None
None
HEM  B 405 ( 4.6A)
None
HEM  B 405 (-3.7A)
0.82A 3a50C-3ejbB:
47.5
3a50C-3ejbB:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz4 PUTATIVE ARSENATE
REDUCTASE


(Streptococcus
mutans)
PF03960
(ArsC)
5 ILE A  92
LEU A  51
LEU A  96
ILE A 103
LEU A  46
None
None
None
FMT  A 205 (-4.6A)
None
1.07A 3a50C-3fz4A:
undetectable
3a50C-3fz4A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115


(Bos taurus)
PF04869
(Uso1_p115_head)
5 ILE A 624
LEU A 540
LEU A 581
ILE A 584
LEU A 616
None
1.32A 3a50C-3gq2A:
2.2
3a50C-3gq2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR


(Chromobacterium
violaceum)
PF13377
(Peripla_BP_3)
6 THR A 133
MET A 155
ILE A 305
LEU A  89
ASN A 107
ILE A  92
None
None
None
None
SO4  A   1 (-3.2A)
None
1.35A 3a50C-3h5oA:
undetectable
3a50C-3h5oA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE


(Psychrobacter
arcticus)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 LEU A 349
MET A 120
LEU A 329
ILE A 332
THR A 312
None
1.27A 3a50C-3hn7A:
undetectable
3a50C-3hn7A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyi PROTEIN DUF199/WHIA

(Thermotoga
maritima)
PF02650
(HTH_WhiA)
PF10298
(WhiA_N)
PF14527
(LAGLIDADG_WhiA)
5 ILE A  13
LEU A 115
LEU A 182
ILE A 185
LEU A 120
None
1.24A 3a50C-3hyiA:
undetectable
3a50C-3hyiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
5 LEU A 181
ASN A 111
LEU A 240
ILE A 239
LEU A 141
None
1.31A 3a50C-3iecA:
undetectable
3a50C-3iecA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN


(Cupriavidus
pinatubonensis)
PF07063
(DUF1338)
5 THR A  40
ILE A 138
LEU A   8
LEU A  31
ILE A   5
None
1.31A 3a50C-3iuzA:
undetectable
3a50C-3iuzA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE


(Babesia bovis)
PF00186
(DHFR_1)
PF00303
(Thymidylat_synt)
5 ILE A 108
LEU A 123
LEU A  11
ILE A 122
LEU A  88
None
None
None
None
NAP  A 512 (-4.4A)
1.16A 3a50C-3kjrA:
undetectable
3a50C-3kjrA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE


(Burkholderia
mallei)
PF00551
(Formyl_trans_N)
5 MET A 122
ILE A 124
LEU A 268
ILE A 175
LEU A 108
None
1.26A 3a50C-3louA:
undetectable
3a50C-3louA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16


(Homo sapiens)
PF00069
(Pkinase)
5 MET A 355
ILE A 258
LEU A 300
ILE A 294
LEU A 470
None
1.29A 3a50C-3mtlA:
undetectable
3a50C-3mtlA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyw PUTATIVE
OXIDOREDUCTASE


(Bacteroides
thetaiotaomicron)
PF00106
(adh_short)
5 ILE A  35
LEU A   7
LEU A  62
THR A 125
LEU A  89
None
1.19A 3a50C-3nywA:
undetectable
3a50C-3nywA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onk EPSIN-3

(Saccharomyces
cerevisiae)
PF01417
(ENTH)
5 THR A  59
LEU A  93
LEU A  69
ILE A  72
LEU A 143
None
1.04A 3a50C-3onkA:
undetectable
3a50C-3onkA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8x METHIONYL-TRNA
FORMYLTRANSFERASE


(Yersinia pestis)
PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C)
5 ILE A 273
LYS A 214
LEU A 287
ILE A 246
LEU A 314
None
1.31A 3a50C-3r8xA:
undetectable
3a50C-3r8xA:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9b CYTOCHROME P450
164A2


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 LEU A 180
LEU A 252
ILE A 255
THR A 260
LEU A 184
None
HEM  A 501 ( 4.5A)
D12  A 509 ( 4.1A)
HEM  A 501 (-3.4A)
D12  A 509 ( 4.3A)
0.94A 3a50C-3r9bA:
49.2
3a50C-3r9bA:
39.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 THR A 393
LEU A 429
LEU A 284
ILE A 411
LEU A 404
None
1.32A 3a50C-3s29A:
undetectable
3a50C-3s29A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN


(Enterococcus
faecalis)
PF05043
(Mga)
5 LEU A  88
ASN A  81
LEU A  97
ILE A  94
THR A  10
None
1.20A 3a50C-3sqnA:
undetectable
3a50C-3sqnA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE


(Escherichia
coli)
PF01450
(IlvC)
PF07991
(IlvN)
5 THR A 198
MET A  56
ILE A  63
LEU A 105
ILE A 103
THR  A 198 ( 0.8A)
MET  A  56 ( 0.0A)
ILE  A  63 ( 0.7A)
LEU  A 105 (-0.5A)
ILE  A 103 ( 0.7A)
1.31A 3a50C-3ulkA:
undetectable
3a50C-3ulkA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE


(Coxiella
burnetii)
PF01041
(DegT_DnrJ_EryC1)
5 ILE A 196
LEU A 186
ASN A 238
MET A 241
ILE A 160
None
1.21A 3a50C-3uwcA:
undetectable
3a50C-3uwcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvj OVALBUMIN

(Dromaius
novaehollandiae)
PF00079
(Serpin)
5 ILE A  58
ASN A 375
ILE A  63
THR A  76
LEU A  84
None
1.28A 3a50C-3vvjA:
undetectable
3a50C-3vvjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1


(Saccharomyces
cerevisiae)
no annotation 5 ILE A 331
LEU A 325
LEU A 296
ILE A 300
LEU A 364
None
1.31A 3a50C-3vwaA:
2.1
3a50C-3vwaA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwy D-LACTATE
DEHYDROGENASE


(Fusobacterium
nucleatum)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 ILE A 255
LYS A 121
ASN A 123
LEU A 232
ILE A 231
None
GOL  A 405 (-3.1A)
None
None
None
1.28A 3a50C-3wwyA:
undetectable
3a50C-3wwyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
5 ILE A 112
ASN A 364
LEU A 236
ILE A 233
THR A 172
None
1.18A 3a50C-3zuqA:
undetectable
3a50C-3zuqA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a8e PROBABLE TYROSINE
RECOMBINASE
XERC-LIKE


(Pyrococcus
abyssi)
PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1)
5 ILE A 169
LEU A 124
LEU A 174
ILE A 177
LEU A 142
None
1.28A 3a50C-4a8eA:
2.7
3a50C-4a8eA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azc BETA-N-ACETYLHEXOSAM
INIDASE


(Streptococcus
pneumoniae)
PF00728
(Glyco_hydro_20)
5 LEU A 887
LEU A 868
ILE A 869
THR A 897
LEU A 931
None
None
None
MG  A2045 (-4.7A)
None
1.26A 3a50C-4azcA:
undetectable
3a50C-4azcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3s ALDEHYDE
DEHYDROGENASE


(Lachnoclostridium
phytofermentans)
PF00171
(Aldedh)
5 ILE A 343
LEU A 309
ASN A 319
LEU A 329
ILE A 332
None
1.14A 3a50C-4c3sA:
undetectable
3a50C-4c3sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115


(Bacteroides
ovatus)
PF15979
(Glyco_hydro_115)
5 MET A 477
ILE A 473
LEU A 239
ILE A 236
LEU A 204
None
0.95A 3a50C-4c90A:
1.8
3a50C-4c90A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ml9 UNCHARACTERIZED
PROTEIN


(Sebaldella
termitidis)
PF00977
(His_biosynth)
5 THR A 250
ILE A 218
LEU A 255
ASN A 253
ILE A 239
None
None
None
EDO  A 309 (-3.3A)
None
1.23A 3a50C-4ml9A:
undetectable
3a50C-4ml9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8q COATOMER SUBUNIT
DELTA


(Bos taurus)
PF00928
(Adap_comp_sub)
5 THR A 368
MET A 295
ILE A 282
LEU A 284
LEU A 402
None
1.30A 3a50C-4o8qA:
undetectable
3a50C-4o8qA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pv4 PROLINE
AMINOPEPTIDASE P II


(Yersinia pestis)
PF00557
(Peptidase_M24)
PF05195
(AMP_N)
5 ILE A 295
LEU A 379
LEU A 299
ILE A 408
THR A 419
None
1.24A 3a50C-4pv4A:
undetectable
3a50C-4pv4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT


(Aquincola
tertiaricarbonis)
PF01642
(MM_CoA_mutase)
5 ILE A 168
ASN A 527
MET A 529
LEU A 175
ILE A 174
None
1.22A 3a50C-4r3uA:
undetectable
3a50C-4r3uA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN


(synthetic
construct)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 ILE A 216
LEU A 185
ASN A 162
LEU A 195
LEU A 231
None
1.00A 3a50C-4r5cA:
undetectable
3a50C-4r5cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I


(synthetic
construct)
PF12354
(Internalin_N)
PF13855
(LRR_8)
5 ILE A 144
LEU A 113
ASN A  90
LEU A 123
LEU A 161
None
1.22A 3a50C-4r6fA:
undetectable
3a50C-4r6fA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7o GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PUTATIVE


(Bacillus
anthracis)
PF03009
(GDPD)
5 ILE A 139
LEU A 166
LEU A  71
ILE A 151
LEU A 175
None
1.25A 3a50C-4r7oA:
undetectable
3a50C-4r7oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens)
no annotation 5 THR C 218
ILE C 248
ASN C 185
ILE C 228
LEU C 269
None
0.83A 3a50C-4rwtC:
undetectable
3a50C-4rwtC:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u28 PHOSPHORIBOSYL
ISOMERASE A


(Streptomyces
sviceus)
PF00977
(His_biosynth)
5 ILE A 129
LEU A  84
LEU A 107
ILE A  88
LEU A  98
None
1.28A 3a50C-4u28A:
undetectable
3a50C-4u28A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE


(Actinomyces
urogenitalis)
PF00977
(His_biosynth)
5 ILE A 123
LEU A  78
LEU A 101
ILE A  82
LEU A  92
None
1.25A 3a50C-4x2rA:
undetectable
3a50C-4x2rA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9s PHOSPHORIBOSYL
ISOMERASE A


(Streptomyces
sp. Mg1)
PF00977
(His_biosynth)
5 ILE A 127
LEU A  82
LEU A 105
ILE A  86
LEU A  96
None
1.28A 3a50C-4x9sA:
undetectable
3a50C-4x9sA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1


(Rattus
norvegicus)
PF00069
(Pkinase)
5 ILE A 124
LEU A 153
LEU A 216
ILE A 215
LEU A 114
None
1.25A 3a50C-4xrlA:
undetectable
3a50C-4xrlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)


(Homo sapiens)
no annotation 5 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
None
None
GOL  A 505 (-4.2A)
None
None
0.79A 3a50C-4z79A:
undetectable
3a50C-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)


(Homo sapiens)
no annotation 5 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
None
None
NI  A 509 (-4.0A)
None
None
0.75A 3a50C-4z8gA:
undetectable
3a50C-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
5 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
None
0.80A 3a50C-4z94G:
undetectable
3a50C-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg5 5'-NUCLEOTIDASE SURE

(Brucella
abortus)
no annotation 5 THR D 181
ILE D 224
LEU D 165
ILE D 229
THR D 140
None
1.20A 3a50C-4zg5D:
undetectable
3a50C-4zg5D:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens)
PF00240
(ubiquitin)
5 THR A  85
ILE A  89
LEU A 147
ILE A 112
LEU A 119
None
1.19A 3a50C-5b83A:
undetectable
3a50C-5b83A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis)
PF00501
(AMP-binding)
5 ILE A 103
LEU A 204
LEU A 184
ILE A 199
THR A 429
None
1.22A 3a50C-5ey8A:
undetectable
3a50C-5ey8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1


(Homo sapiens)
PF03587
(EMG1)
5 ILE A 118
ASN A  65
LEU A 140
THR A 124
LEU A  92
None
UNX  A 304 ( 4.1A)
None
None
None
1.09A 3a50C-5faiA:
undetectable
3a50C-5faiA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fb8 PRO-INTERLEUKIN-16

(Homo sapiens)
PF00595
(PDZ)
5 THR C  88
ILE C  82
LEU C 105
ILE C 102
LEU C  35
None
1.20A 3a50C-5fb8C:
undetectable
3a50C-5fb8C:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fb8 PRO-INTERLEUKIN-16

(Homo sapiens)
PF00595
(PDZ)
5 THR C  88
MET C  90
ILE C  82
LEU C 105
ILE C 102
None
1.25A 3a50C-5fb8C:
undetectable
3a50C-5fb8C:
14.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
6 THR A  84
MET A  86
ILE A  88
LEU A 232
ILE A 235
THR A 240
None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.7A)
0.43A 3a50C-5gnmA:
56.6
3a50C-5gnmA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE


(Saccharomyces
cerevisiae)
PF04752
(ChaC)
5 ILE A  17
ASN A 131
LEU A 204
ILE A  93
LEU A  11
None
1.21A 3a50C-5hwiA:
undetectable
3a50C-5hwiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER


(Shigella
flexneri)
PF02395
(Peptidase_S6)
5 THR A 191
LEU A 231
ASN A 207
LEU A 178
THR A 244
None
1.15A 3a50C-5j44A:
undetectable
3a50C-5j44A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage)
PF12708
(Pectate_lyase_3)
5 ILE A 161
ASN A 220
LEU A 186
ILE A 183
LEU A 138
None
1.21A 3a50C-5jseA:
undetectable
3a50C-5jseA:
19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l94 CYTOCHROME P450

(Bacillus
megaterium)
PF00067
(p450)
5 ILE A  85
LYS A 187
LEU A 238
ILE A 241
THR A 246
HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.4A)
0.36A 3a50C-5l94A:
49.8
3a50C-5l94A:
34.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1m MATRIX PROTEIN 1

(Influenza C
virus)
PF03026
(CM1)
5 ILE A  29
LEU A  48
ILE A  43
THR A  57
LEU A  14
None
1.23A 3a50C-5m1mA:
undetectable
3a50C-5m1mA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A


(Leptotrichia
buccalis)
no annotation 5 ILE A 563
LEU A 699
ASN A 695
ILE A 702
LEU A 596
None
1.31A 3a50C-5xwyA:
2.7
3a50C-5xwyA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ep3 -

(-)
no annotation 5 ILE A  20
ASN A  65
LEU A  54
ILE A  51
LEU A  36
None
1.25A 3a50C-6ep3A:
1.6
3a50C-6ep3A:
undetectable