SIMILAR PATTERNS OF AMINO ACIDS FOR 3A50_A_VD3A2001
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bh9 | TAFII18TAFII28 (Homo sapiens) |
PF02269(TFIID-18kDa)PF04719(TAFII28) | 5 | THR A 69ILE A 62LEU B 137ILE B 134ALA B 133 | None | 1.18A | 3a50A-1bh9A:undetectable | 3a50A-1bh9A:8.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gff | BACTERIOPHAGE G4CAPSID PROTEINS GPF,GPG, GPJ (Escherichiavirus G4) |
PF02305(Phage_F) | 5 | THR 1 406MET 1 404ILE 1 49ASN 1 409ILE 1 66 | None | 1.09A | 3a50A-1gff1:undetectable | 3a50A-1gff1:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h6d | PRECURSOR FORM OFGLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | MET A 342ILE A 353ASN A 272LEU A 340ILE A 223 | None | 1.21A | 3a50A-1h6dA:undetectable | 3a50A-1h6dA:24.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1w | ISOCITRATEDEHYDROGENASE (Azotobactervinelandii) |
PF03971(IDH) | 5 | PRO A 718ILE A 97LEU A 44ILE A 86ALA A 88 | NoneNoneNoneNAP A1000 ( 4.2A)None | 1.05A | 3a50A-1j1wA:0.0 | 3a50A-1j1wA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5t | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Thermotogamaritima) |
PF00218(IGPS) | 5 | ILE A 212LEU A 222ILE A 22ALA A 53LEU A 207 | None | 0.92A | 3a50A-1j5tA:undetectable | 3a50A-1j5tA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ldn | L-LACTATEDEHYDROGENASE (Geobacillusstearothermophilus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 164LEU A 270ILE A 293ALA A 261LEU A 134 | None | 1.05A | 3a50A-1ldnA:0.0 | 3a50A-1ldnA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mqq | ALPHA-D-GLUCURONIDASE (Geobacillusstearothermophilus) |
PF03648(Glyco_hydro_67N)PF07477(Glyco_hydro_67C)PF07488(Glyco_hydro_67M) | 5 | THR A 381MET A 378ASN A 302LEU A 374ALA A 339 | None | 1.19A | 3a50A-1mqqA:0.0 | 3a50A-1mqqA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o20 | GAMMA-GLUTAMYLPHOSPHATE REDUCTASE (Thermotogamaritima) |
PF00171(Aldedh) | 5 | THR A 292ILE A 275LEU A 261ILE A 316THR A 249 | None | 1.14A | 3a50A-1o20A:undetectable | 3a50A-1o20A:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qwk | ALDO-KETO REDUCTASEFAMILY 1 MEMBER C1 (Caenorhabditiselegans) |
PF00248(Aldo_ket_red) | 5 | PRO A 17ILE A 46LEU A 21ALA A 34LEU A 65 | None | 1.15A | 3a50A-1qwkA:undetectable | 3a50A-1qwkA:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1suv | TRANSFERRIN RECEPTORPROTEIN 1 (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | MET A 635ILE A 632LEU A 637THR A 739LEU A 712 | None | 1.20A | 3a50A-1suvA:undetectable | 3a50A-1suvA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uf2 | CORE PROTEIN P3 (Rice dwarfvirus) |
PF09231(RDV-p3) | 5 | MET A 317ILE A 648LEU A 315ALA A 357LEU A 641 | None | 1.18A | 3a50A-1uf2A:1.0 | 3a50A-1uf2A:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x7f | OUTER SURFACEPROTEIN (Bacillus cereus) |
PF05913(DUF871) | 5 | ILE A 163ASN A 122LEU A 219ILE A 220LEU A 199 | None | 1.10A | 3a50A-1x7fA:undetectable | 3a50A-1x7fA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2atm | HYALURONOGLUCOSAMINIDASE (Vespulavulgaris) |
PF01630(Glyco_hydro_56) | 5 | ILE A 295LEU A 319ILE A 322ALA A 323THR A 327 | None | 1.06A | 3a50A-2atmA:undetectable | 3a50A-2atmA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4v | ISOCITRATEDEHYDROGENASE (Acidithiobacillusthiooxidans) |
PF00180(Iso_dh) | 5 | ILE A 32ASN A 155ILE A 92ALA A 91LEU A 84 | None | 1.18A | 3a50A-2d4vA:undetectable | 3a50A-2d4vA:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fiq | PUTATIVE TAGATOSE6-PHOSPHATE KINASE 1 (Escherichiacoli) |
PF08013(Tagatose_6_P_K) | 5 | ASN A 360LEU A 295ILE A 292ALA A 291LEU A 25 | None | 0.99A | 3a50A-2fiqA:undetectable | 3a50A-2fiqA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hlp | MALATE DEHYDROGENASE (Haloarculamarismortui) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 45ASN A 131ILE A 261ALA A 260THR A 265 | None | 1.16A | 3a50A-2hlpA:undetectable | 3a50A-2hlpA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2llh | NUCLEOPHOSMIN (Homo sapiens) |
PF16276(NPM1-C) | 5 | PRO A 38ILE A 23LEU A 63ILE A 60ALA A 59 | None | 1.04A | 3a50A-2llhA:undetectable | 3a50A-2llhA:10.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pkg | SERINE/THREONINE-PROTEIN PHOSPHATASE 2A65 KDA REGULATORYSUBUNIT A ALPHAISOFORM (Homo sapiens) |
PF02985(HEAT)PF13646(HEAT_2) | 5 | ASN A 22ILE A 38ALA A 39THR A 47LEU A 55 | None | 1.09A | 3a50A-2pkgA:undetectable | 3a50A-2pkgA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qkb | RIBONUCLEASE H1 (Homo sapiens) |
PF00075(RNase_H) | 5 | ILE A 218LEU A 247ILE A 187ALA A 190THR A 144 | None | 1.20A | 3a50A-2qkbA:undetectable | 3a50A-2qkbA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2quq | CENTROMEREDNA-BINDING PROTEINCOMPLEX CBF3 SUBUNITB (Saccharomycescerevisiae) |
PF16846(Cep3) | 5 | MET A 174ILE A 171LEU A 179ILE A 182LEU A 106 | None | 0.98A | 3a50A-2quqA:1.6 | 3a50A-2quqA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2tpt | THYMIDINEPHOSPHORYLASE (Escherichiacoli) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 5 | PRO A 137ILE A 112ASN A 140LEU A 160ALA A 193 | None | 1.16A | 3a50A-2tptA:undetectable | 3a50A-2tptA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ux8 | GLUCOSE-1-PHOSPHATEURIDYLYLTRANSFERASE (Sphingomonaselodea) |
PF00483(NTP_transferase) | 5 | ILE A 209LEU A 6ILE A 52ALA A 50LEU A 130 | None | 1.12A | 3a50A-2ux8A:undetectable | 3a50A-2ux8A:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3w | DIHYDROFOLATEREDUCTASE (Mycobacteriumavium) |
PF00186(DHFR_1) | 5 | THR A 50ILE A 24ASN A 66ALA A 11LEU A 32 | NDP A1169 (-3.4A)NDP A1169 ( 4.4A)NoneVG9 A1168 ( 3.8A)VG9 A1168 (-4.7A) | 1.17A | 3a50A-2w3wA:undetectable | 3a50A-2w3wA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2whk | MANNANENDO-1,4-BETA-MANNOSIDASE (Bacillussubtilis) |
PF02156(Glyco_hydro_26) | 5 | PRO A 159ILE A 63ILE A 236ALA A 263THR A 292 | None | 1.13A | 3a50A-2whkA:undetectable | 3a50A-2whkA:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0f | WSAF (Geobacillusstearothermophilus) |
no annotation | 5 | PRO A 331ILE A 342ILE A 260ALA A 263LEU A 364 | None | 1.14A | 3a50A-2x0fA:undetectable | 3a50A-2x0fA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z65 | TOLL-LIKE RECEPTOR4, VARIABLELYMPHOCYTE RECEPTORB (Eptatretusburgeri;Homo sapiens) |
PF11921(DUF3439)PF13306(LRR_5)PF13855(LRR_8) | 5 | ILE A 146LEU A 131ALA A 133THR A 136LEU A 117 | None | 1.14A | 3a50A-2z65A:undetectable | 3a50A-2z65A:19.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zbz | CYTOCHROME P450-SU1 (Streptomycesgriseolus) |
PF00067(p450) | 5 | ASN A 194LEU A 240ILE A 243ALA A 244THR A 248 | NoneHEM A 413 ( 4.5A)VDX A 501 (-4.2A)HEM A 413 (-3.5A)HEM A 413 (-3.2A) | 0.97A | 3a50A-2zbzA:47.1 | 3a50A-2zbzA:37.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zbz | CYTOCHROME P450-SU1 (Streptomycesgriseolus) |
PF00067(p450) | 5 | ILE A 96LEU A 240ILE A 243ALA A 244THR A 248 | HEM A 413 (-4.0A)HEM A 413 ( 4.5A)VDX A 501 (-4.2A)HEM A 413 (-3.5A)HEM A 413 (-3.2A) | 0.54A | 3a50A-2zbzA:47.1 | 3a50A-2zbzA:37.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aiz | DNA POLYMERASESLIDING CLAMP C (Sulfurisphaeratokodaii) |
PF00705(PCNA_N)PF02747(PCNA_C) | 5 | THR C 75ILE C 25LEU C 18ILE C 14LEU C 34 | None | 1.11A | 3a50A-3aizC:undetectable | 3a50A-3aizC:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cuq | VACUOLAR-SORTINGPROTEIN SNF8 (Homo sapiens) |
PF04157(EAP30) | 5 | ILE A 105LEU A 151ILE A 148ALA A 147LEU A 124 | None | 1.06A | 3a50A-3cuqA:undetectable | 3a50A-3cuqA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dh9 | THIOREDOXINREDUCTASE 1 (Drosophilamelanogaster) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | ILE A 15ILE A 327ALA A 323THR A 316LEU A 296 | FAD A 500 (-4.8A)NoneNoneNoneNone | 1.15A | 3a50A-3dh9A:undetectable | 3a50A-3dh9A:22.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ejb | BIOTIN BIOSYNTHESISCYTOCHROME P450-LIKEENZYME (Bacillussubtilis) |
PF00067(p450) | 6 | MET B 79ASN B 181LEU B 230ILE B 233ALA B 234THR B 238 | NoneNoneHEM B 405 ( 4.6A)NoneHEM B 405 (-3.5A)HEM B 405 (-3.7A) | 0.76A | 3a50A-3ejbB:47.2 | 3a50A-3ejbB:36.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3evr | MYOSIN LIGHT CHAINKINASE, GREENFLUORESCENT PROTEIN,CALMODULIN-1 CHIMERA (Aequoreavictoria;Rattusnorvegicus) |
PF01353(GFP)PF13499(EF-hand_7) | 5 | MET A 354ASN A 345LEU A 57ILE A 54ALA A 53 | None | 0.95A | 3a50A-3evrA:undetectable | 3a50A-3evrA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg2 | PUTATIVE RUBREDOXINREDUCTASE (Rhodopseudomonaspalustris) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 5 | THR P 95LEU P 89ILE P 32ALA P 7THR P 106 | NoneNoneFAD P 449 ( 4.5A)FAD P 449 ( 4.7A)FAD P 449 (-4.1A) | 1.16A | 3a50A-3fg2P:undetectable | 3a50A-3fg2P:23.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fxi | TOLL-LIKE RECEPTOR 4 (Homo sapiens) |
PF13516(LRR_6)PF13855(LRR_8) | 5 | ILE A 146LEU A 131ALA A 133THR A 136LEU A 117 | None | 1.15A | 3a50A-3fxiA:undetectable | 3a50A-3fxiA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h3j | L-LACTATEDEHYDROGENASE 1 (Staphylococcusaureus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 150LEU A 255ILE A 278ALA A 246LEU A 120 | None | 1.15A | 3a50A-3h3jA:undetectable | 3a50A-3h3jA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h7u | ALDO-KETO REDUCTASE (Arabidopsisthaliana) |
PF00248(Aldo_ket_red) | 5 | PRO A 17ILE A 46LEU A 21ALA A 34LEU A 65 | None | 1.18A | 3a50A-3h7uA:undetectable | 3a50A-3h7uA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iby | FERROUS IRONTRANSPORT PROTEIN B (Legionellapneumophila) |
PF02421(FeoB_N) | 5 | THR A 22ILE A 154LEU A 17ILE A 88ALA A 116 | None | 1.12A | 3a50A-3ibyA:undetectable | 3a50A-3ibyA:19.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ics | COENZYME A-DISULFIDEREDUCTASE (Bacillusanthracis) |
PF00581(Rhodanese)PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | TRP A 459ILE A 382ASN A 186LEU A 350ILE A 349 | None | 1.14A | 3a50A-3icsA:undetectable | 3a50A-3icsA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iib | PEPTIDASE M28 (Shewanellaamazonensis) |
PF04389(Peptidase_M28) | 5 | PRO A 125THR A 124ILE A 219ILE A 154ALA A 155 | None | 0.90A | 3a50A-3iibA:undetectable | 3a50A-3iibA:24.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khz | PUTATIVE DIPEPTIDASESACOL1801 (Staphylococcusaureus) |
PF01546(Peptidase_M20) | 5 | PRO A 101ILE A 446ILE A 121ALA A 122THR A 455 | None | 1.21A | 3a50A-3khzA:undetectable | 3a50A-3khzA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kq4 | CUBILIN (Homo sapiens) |
PF00431(CUB) | 5 | PRO B1179LEU B1085ILE B1086ALA B1087LEU B1120 | None | 1.10A | 3a50A-3kq4B:undetectable | 3a50A-3kq4B:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myu | HIGH AFFINITYTRANSPORT SYSTEMPROTEIN P37 (Mycoplasmagenitalium) |
PF06646(Mycoplasma_p37) | 5 | ILE A 67ASN A 37LEU A 59ILE A 324ALA A 323 | None | 1.02A | 3a50A-3myuA:undetectable | 3a50A-3myuA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3myu | HIGH AFFINITYTRANSPORT SYSTEMPROTEIN P37 (Mycoplasmagenitalium) |
PF06646(Mycoplasma_p37) | 5 | ILE A 67ASN A 72LEU A 59ILE A 324ALA A 323 | None | 1.09A | 3a50A-3myuA:undetectable | 3a50A-3myuA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ot5 | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Listeriamonocytogenes) |
PF02350(Epimerase_2) | 5 | THR A 36ILE A 9ILE A 86ALA A 109LEU A 117 | None | 1.07A | 3a50A-3ot5A:undetectable | 3a50A-3ot5A:24.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3r9b | CYTOCHROME P450164A2 (Mycolicibacteriumsmegmatis) |
PF00067(p450) | 5 | LEU A 252ILE A 255ALA A 256THR A 260LEU A 184 | HEM A 501 ( 4.5A)D12 A 509 ( 4.1A)HEM A 501 ( 3.5A)HEM A 501 (-3.4A)D12 A 509 ( 4.3A) | 0.94A | 3a50A-3r9bA:48.5 | 3a50A-3r9bA:39.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ti7 | BASIC EXTRACELLULARSUBTILISIN-LIKEPROTEASE BPRV (Dichelobacternodosus) |
PF00082(Peptidase_S8) | 5 | ILE A 309ASN A 174LEU A 301ILE A 291ALA A 294 | None | 1.06A | 3a50A-3ti7A:undetectable | 3a50A-3ti7A:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v94 | CYCLIC NUCLEOTIDESPECIFICPHOSPHODIESTERASE (Trypanosomacruzi) |
PF00233(PDEase_I) | 5 | PRO A 389ILE A 592LEU A 383ALA A 519THR A 581 | None | 1.16A | 3a50A-3v94A:undetectable | 3a50A-3v94A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3won | DIPEPTIDYLAMINOPEPTIDASE BII (Pseudoxanthomonasmexicana) |
PF10459(Peptidase_S46) | 5 | ILE A 53LYS A 25LEU A 34ILE A 37ALA A 38 | None | 1.12A | 3a50A-3wonA:2.3 | 3a50A-3wonA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zs7 | PYRIDOXAL KINASE (Trypanosomabrucei) |
PF08543(Phos_pyr_kin) | 5 | PRO A 148ILE A 145LEU A 235ILE A 248ALA A 247 | None | 1.05A | 3a50A-3zs7A:undetectable | 3a50A-3zs7A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3t | DNA MISMATCH REPAIRPROTEIN HSM3 (Saccharomycescerevisiae) |
no annotation | 5 | ILE A 135LEU A 160ILE A 156ALA A 159LEU A 105 | None | 1.21A | 3a50A-4a3tA:undetectable | 3a50A-4a3tA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bwc | PHOSPHOLIPASE B-LIKE1 (Bos taurus) |
PF04916(Phospholip_B) | 5 | THR A 107LEU A 102ILE A 81ALA A 63LEU B 545 | None | 1.20A | 3a50A-4bwcA:2.0 | 3a50A-4bwcA:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1t | SUGAR TRANSPORTERSOLUTE-BINDINGPROTEIN (Bifidobacteriumanimalis) |
PF01547(SBP_bac_1) | 5 | PRO A 301MET A 150ILE A 187ALA A 188LEU A 179 | None | 1.18A | 3a50A-4c1tA:undetectable | 3a50A-4c1tA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgt | CYCLODEXTRINGLYCOSYLTRANSFERASE (Bacilluscirculans) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | PRO A 356LEU A 346ALA A 387THR A 385LEU A 69 | None | 1.20A | 3a50A-4cgtA:undetectable | 3a50A-4cgtA:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ee9 | ENDOGLUCANASE (unculturedbacterium) |
PF00150(Cellulase) | 5 | ILE A 117ASN A 8LEU A 55ALA A 68LEU A 75 | None | 1.08A | 3a50A-4ee9A:undetectable | 3a50A-4ee9A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8d | ALPHA/BETA HYDROLASEFOLD PROTEIN (Ochrobactrumsp. T63) |
PF00561(Abhydrolase_1) | 5 | THR A 126ILE A 107ALA A 81THR A 85LEU A 28 | None | 1.20A | 3a50A-4g8dA:undetectable | 3a50A-4g8dA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4glf | RSFP (unculturedbacterium) |
PF01048(PNP_UDP_1) | 5 | PRO A 77ILE A 19LEU A 85ILE A 49ALA A 60 | None | 1.16A | 3a50A-4glfA:undetectable | 3a50A-4glfA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i2y | RGECO1 (Discosoma sp.;Gallus gallus;Rattusnorvegicus) |
PF01353(GFP)PF13499(EF-hand_7) | 5 | MET A 354ASN A 345LEU A 56ILE A 53ALA A 52 | None | 1.00A | 3a50A-4i2yA:undetectable | 3a50A-4i2yA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ijr | D-ARABINOSEDEHYDROGENASE[NAD(P)+] HEAVYCHAIN (Saccharomycescerevisiae) |
PF00248(Aldo_ket_red) | 5 | PRO A 34ILE A 65LEU A 38ALA A 53LEU A 84 | None | 1.22A | 3a50A-4ijrA:undetectable | 3a50A-4ijrA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m5p | NADPH DEHYDROGENASE (Scheffersomycesstipitis) |
PF00724(Oxidored_FMN) | 5 | THR A 66ILE A 185LEU A 112ILE A 85ALA A 173 | None | 1.09A | 3a50A-4m5pA:undetectable | 3a50A-4m5pA:24.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otm | SERINE/THREONINE-PROTEIN KINASE GCN2 (Saccharomycescerevisiae) |
PF12745(HGTP_anticodon2) | 5 | ILE A1627LEU A1644ILE A1655ALA A1642LEU A1601 | None | 1.14A | 3a50A-4otmA:undetectable | 3a50A-4otmA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ppz | SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE (Neisseriameningitidis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 6 | ASN A 51LEU A 13ILE A 106ALA A 107THR A 111LEU A 34 | None | 1.29A | 3a50A-4ppzA:undetectable | 3a50A-4ppzA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qhi | UNCHARACTERIZEDPROTEIN MJ1213 (Methanocaldococcusjannaschii) |
PF01435(Peptidase_M48) | 5 | THR A 14ILE A 29ILE A 66ALA A 39LEU A 55 | None | 1.06A | 3a50A-4qhiA:undetectable | 3a50A-4qhiA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r5c | LEUCINE RICH REPEATPROTEIN (syntheticconstruct) |
PF12354(Internalin_N)PF12799(LRR_4)PF13516(LRR_6)PF13855(LRR_8) | 5 | ILE A 216ASN A 162LEU A 195ALA A 221LEU A 231 | None | 0.94A | 3a50A-4r5cA:undetectable | 3a50A-4r5cA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rwt | LEIOMODIN-2 (Homo sapiens) |
no annotation | 5 | ILE C 248ASN C 185ILE C 228ALA C 229LEU C 269 | None | 1.02A | 3a50A-4rwtC:undetectable | 3a50A-4rwtC:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rwt | LEIOMODIN-2 (Homo sapiens) |
no annotation | 5 | THR C 218ILE C 248ASN C 185ILE C 228LEU C 269 | None | 0.84A | 3a50A-4rwtC:undetectable | 3a50A-4rwtC:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u8u | GLOBIN C CHAIN (Glossoscolexpaulistus) |
PF00042(Globin) | 5 | ILE C 114ASN C 74LEU C 142ILE C 145ALA C 146 | HEM C 201 (-3.6A)NoneHEM C 201 (-4.8A)NoneNone | 1.13A | 3a50A-4u8uC:undetectable | 3a50A-4u8uC:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xsr | ALR3699 PROTEIN (Nostoc sp. PCC7120) |
no annotation | 5 | THR B 347ILE B 337LEU B 279ALA B 281THR B 283 | None | 1.21A | 3a50A-4xsrB:undetectable | 3a50A-4xsrB:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yfv | VIOF (Providenciaalcalifaciens) |
PF00551(Formyl_trans_N) | 5 | ILE A 72ASN A 98LEU A 166ILE A 169LEU A 89 | None | 1.18A | 3a50A-4yfvA:undetectable | 3a50A-4yfvA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z79 | LEIOMODIN-1ACTIN-BINDING SITE 2(ABS2) (Homo sapiens) |
no annotation | 5 | ILE A 399ASN A 336ILE A 379ALA A 380LEU A 420 | NoneGOL A 505 (-4.2A)NoneGOL A 502 (-3.6A)None | 0.98A | 3a50A-4z79A:undetectable | 3a50A-4z79A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z79 | LEIOMODIN-1ACTIN-BINDING SITE 2(ABS2) (Homo sapiens) |
no annotation | 5 | THR A 369ILE A 399ASN A 336ILE A 379LEU A 420 | NoneNoneGOL A 505 (-4.2A)NoneNone | 0.79A | 3a50A-4z79A:undetectable | 3a50A-4z79A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8g | TROPOMODULIN-1,LEIOMODIN-1 CHIMERA(TP1 ABS2) (Homo sapiens) |
no annotation | 5 | ILE A 399ASN A 201ILE A 379ALA A 380LEU A 420 | None NI A 509 (-4.0A)NoneNoneNone | 0.92A | 3a50A-4z8gA:undetectable | 3a50A-4z8gA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z8g | TROPOMODULIN-1,LEIOMODIN-1 CHIMERA(TP1 ABS2) (Homo sapiens) |
no annotation | 5 | THR A 369ILE A 399ASN A 201ILE A 379LEU A 420 | NoneNone NI A 509 (-4.0A)NoneNone | 0.76A | 3a50A-4z8gA:undetectable | 3a50A-4z8gA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z94 | GELSOLIN,TROPOMODULIN-1,LEIOMODIN-1 CHIMERA (Homo sapiens) |
PF00626(Gelsolin) | 5 | ILE G1399ASN G1201ILE G1379ALA G1380LEU G1420 | None | 1.02A | 3a50A-4z94G:undetectable | 3a50A-4z94G:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z94 | GELSOLIN,TROPOMODULIN-1,LEIOMODIN-1 CHIMERA (Homo sapiens) |
PF00626(Gelsolin) | 5 | THR G1369ILE G1399ASN G1201ILE G1379LEU G1420 | None | 0.82A | 3a50A-4z94G:undetectable | 3a50A-4z94G:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ztb | PROTEASE NSP2 (Chikungunyavirus) |
PF01707(Peptidase_C9) | 5 | ASN A 110LEU A 13ILE A 51ALA A 47LEU A 60 | None | 1.02A | 3a50A-4ztbA:undetectable | 3a50A-4ztbA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d0n | PYRUVATE, PHOSPHATEDIKINASE REGULATORYPROTEIN,CHLOROPLASTIC (Zea mays) |
PF03618(Kinase-PPPase) | 5 | THR A 272ILE A 289LEU A 306ALA A 403LEU A 339 | None | 1.04A | 3a50A-5d0nA:undetectable | 3a50A-5d0nA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fai | RIBOSOMAL RNA SMALLSUBUNITMETHYLTRANSFERASENEP1 (Homo sapiens) |
PF03587(EMG1) | 5 | ILE A 118ASN A 65LEU A 140THR A 124LEU A 92 | NoneUNX A 304 ( 4.1A)NoneNoneNone | 1.09A | 3a50A-5faiA:undetectable | 3a50A-5faiA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gj8 | ACYL-COADEHYDROGENASE TYPE 2DOMAIN PROTEIN (Alicyclobacillusacidocaldarius) |
PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N)PF08028(Acyl-CoA_dh_2) | 5 | THR A 58ILE A 97LYS A 50THR A 165LEU A 170 | None | 0.98A | 3a50A-5gj8A:1.1 | 3a50A-5gj8A:22.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 5 | LYS A 180ASN A 181ILE A 235ALA A 236THR A 240 | NoneNoneNoneHEM A 501 (-3.6A)HEM A 501 (-3.7A) | 1.10A | 3a50A-5gnmA:56.7 | 3a50A-5gnmA:98.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 7 | PRO A 83THR A 84MET A 86ILE A 88ILE A 235ALA A 236LEU A 387 | NoneNoneNoneHEM A 501 ( 4.4A)NoneHEM A 501 (-3.6A)None | 0.85A | 3a50A-5gnmA:56.7 | 3a50A-5gnmA:98.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gnm | VITAMIN D(3)25-HYDROXYLASE (Pseudonocardiaautotrophica) |
PF00067(p450) | 8 | PRO A 83THR A 84MET A 86ILE A 88LEU A 232ILE A 235ALA A 236THR A 240 | NoneNoneNoneHEM A 501 ( 4.4A)HEM A 501 ( 4.7A)NoneHEM A 501 (-3.6A)HEM A 501 (-3.7A) | 0.64A | 3a50A-5gnmA:56.7 | 3a50A-5gnmA:98.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hwi | GLUTATHIONE-SPECIFICGAMMA-GLUTAMYLCYCLOTRANSFERASE (Saccharomycescerevisiae) |
PF04752(ChaC) | 5 | ILE A 17ASN A 131LEU A 204ILE A 93LEU A 11 | None | 1.21A | 3a50A-5hwiA:undetectable | 3a50A-5hwiA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jen | ANTI-SIGMA-V FACTORRSIV (Bacillussubtilis) |
PF11738(DUF3298)PF13739(DUF4163) | 5 | PRO A 99THR A 98ILE A 162ASN A 114LEU A 124 | None | 0.76A | 3a50A-5jenA:undetectable | 3a50A-5jenA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jh1 | ALDOSE REDUCTASE,AKR4C7 (Zea mays) |
PF00248(Aldo_ket_red) | 5 | PRO A 14ILE A 43LEU A 18ALA A 31LEU A 62 | None | 1.19A | 3a50A-5jh1A:undetectable | 3a50A-5jh1A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5joq | LMO2184 PROTEIN (Listeriamonocytogenes) |
PF01497(Peripla_BP_2) | 5 | PRO A 66ILE A 47LEU A 51ALA A 143LEU A 150 | None | 1.15A | 3a50A-5joqA:undetectable | 3a50A-5joqA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jse | PHIAB6 TAILSPIKE (unidentifiedphage) |
PF12708(Pectate_lyase_3) | 5 | ILE A 161ASN A 220LEU A 186ILE A 183LEU A 138 | None | 1.18A | 3a50A-5jseA:undetectable | 3a50A-5jseA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jwf | ASP/GLU-SPECIFICDIPEPTIDYL-PEPTIDASE (Porphyromonasgingivalis) |
PF10459(Peptidase_S46) | 5 | ILE A 259ASN A 83LEU A 700ILE A 703LEU A 79 | None | 1.19A | 3a50A-5jwfA:undetectable | 3a50A-5jwfA:22.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l94 | CYTOCHROME P450 (Bacillusmegaterium) |
PF00067(p450) | 6 | ILE A 85LYS A 187LEU A 238ILE A 241ALA A 242THR A 246 | HEM A 501 (-4.4A)NoneHEM A 501 (-4.4A)TES A 502 (-4.0A)HEM A 501 (-3.5A)HEM A 501 (-3.4A) | 0.47A | 3a50A-5l94A:49.2 | 3a50A-5l94A:34.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lxv | SCAFFOLDIN C (Ruminococcusflavefaciens) |
PF00963(Cohesin) | 5 | ILE A 37LEU A 108ILE A 58ALA A 59THR A 61 | None | 0.97A | 3a50A-5lxvA:undetectable | 3a50A-5lxvA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oom | 39S RIBOSOMALPROTEIN L22,MITOCHONDRIAL (Homo sapiens) |
PF00237(Ribosomal_L22) | 5 | PRO T 183ILE T 142LEU T 178ALA T 124LEU T 103 | None | 1.15A | 3a50A-5oomT:undetectable | 3a50A-5oomT:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ucd | NAD(P)-DEPENDENTBENZALDEHYDEDEHYDROGENASE (Pseudomonasputida) |
PF00171(Aldedh) | 5 | ILE A 134ASN A 45LEU A 35ILE A 76ALA A 79 | None | 1.18A | 3a50A-5ucdA:undetectable | 3a50A-5ucdA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uz9 | CRISPR-ASSOCIATEDPROTEIN CSY3 (Pseudomonasaeruginosa) |
PF09615(Cas_Csy3) | 5 | ILE C 181LEU C 214ILE C 218ALA C 158LEU C 283 | None | 1.15A | 3a50A-5uz9C:undetectable | 3a50A-5uz9C:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vf4 | UNCHARACTERIZEDPROTEIN (Thermusaquaticus) |
PF03781(FGE-sulfatase) | 5 | ILE A 212ASN A 218LEU A 316ALA A 322LEU A 360 | None | 1.19A | 3a50A-5vf4A:undetectable | 3a50A-5vf4A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vj1 | MDCA (Pseudomonasaeruginosa) |
PF16957(Mal_decarbox_Al) | 5 | MET A 420ILE A 268ALA A 266THR A 296LEU A 291 | None | 1.18A | 3a50A-5vj1A:undetectable | 3a50A-5vj1A:24.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxo | PERIPLASMICBETA-GLUCOSIDASE (Bacteroidesthetaiotaomicron) |
no annotation | 5 | ILE A 586ASN A 413LEU A 447ILE A 511ALA A 513 | None | 1.21A | 3a50A-5xxoA:undetectable | 3a50A-5xxoA:10.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ysm | CYTOCHROME P450 (Amycolatopsismediterranei) |
no annotation | 5 | ILE A 107LEU A 252ILE A 255ALA A 256THR A 260 | HEM A 501 (-4.2A)HEM A 501 ( 4.6A)NoneHEM A 501 (-3.4A)HEM A 501 (-3.7A) | 0.80A | 3a50A-5ysmA:39.8 | 3a50A-5ysmA:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bwc | POLYSACCHARIDEBIOSYNTHESIS PROTEINCAPD (Bacillusthuringiensis) |
no annotation | 5 | PRO A 286MET A 288ILE A 290ILE A 218ALA A 219 | None | 1.08A | 3a50A-6bwcA:undetectable | 3a50A-6bwcA:10.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccz | SERINEHYDROXYMETHYLTRANSFERASE (Medicagotruncatula) |
no annotation | 5 | ILE A 455LEU A 390ILE A 473ALA A 474LEU A 429 | None | 1.15A | 3a50A-6cczA:undetectable | 3a50A-6cczA:11.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ep3 | - (-) |
no annotation | 5 | ASN A 65LEU A 54ILE A 51ALA A 50LEU A 36 | None | 1.08A | 3a50A-6ep3A:2.0 | 3a50A-6ep3A:undetectable |