SIMILAR PATTERNS OF AMINO ACIDS FOR 3A50_A_VD3A2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bh9 TAFII18
TAFII28


(Homo sapiens)
PF02269
(TFIID-18kDa)
PF04719
(TAFII28)
5 THR A  69
ILE A  62
LEU B 137
ILE B 134
ALA B 133
None
1.18A 3a50A-1bh9A:
undetectable
3a50A-1bh9A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ


(Escherichia
virus G4)
PF02305
(Phage_F)
5 THR 1 406
MET 1 404
ILE 1  49
ASN 1 409
ILE 1  66
None
1.09A 3a50A-1gff1:
undetectable
3a50A-1gff1:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6d PRECURSOR FORM OF
GLUCOSE-FRUCTOSE
OXIDOREDUCTASE


(Zymomonas
mobilis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
5 MET A 342
ILE A 353
ASN A 272
LEU A 340
ILE A 223
None
1.21A 3a50A-1h6dA:
undetectable
3a50A-1h6dA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF03971
(IDH)
5 PRO A 718
ILE A  97
LEU A  44
ILE A  86
ALA A  88
None
None
None
NAP  A1000 ( 4.2A)
None
1.05A 3a50A-1j1wA:
0.0
3a50A-1j1wA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE


(Thermotoga
maritima)
PF00218
(IGPS)
5 ILE A 212
LEU A 222
ILE A  22
ALA A  53
LEU A 207
None
0.92A 3a50A-1j5tA:
undetectable
3a50A-1j5tA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 164
LEU A 270
ILE A 293
ALA A 261
LEU A 134
None
1.05A 3a50A-1ldnA:
0.0
3a50A-1ldnA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E


(Geobacillus
stearothermophilus)
PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M)
5 THR A 381
MET A 378
ASN A 302
LEU A 374
ALA A 339
None
1.19A 3a50A-1mqqA:
0.0
3a50A-1mqqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE


(Thermotoga
maritima)
PF00171
(Aldedh)
5 THR A 292
ILE A 275
LEU A 261
ILE A 316
THR A 249
None
1.14A 3a50A-1o20A:
undetectable
3a50A-1o20A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwk ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1


(Caenorhabditis
elegans)
PF00248
(Aldo_ket_red)
5 PRO A  17
ILE A  46
LEU A  21
ALA A  34
LEU A  65
None
1.15A 3a50A-1qwkA:
undetectable
3a50A-1qwkA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1


(Homo sapiens)
PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28)
5 MET A 635
ILE A 632
LEU A 637
THR A 739
LEU A 712
None
1.20A 3a50A-1suvA:
undetectable
3a50A-1suvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus)
PF09231
(RDV-p3)
5 MET A 317
ILE A 648
LEU A 315
ALA A 357
LEU A 641
None
1.18A 3a50A-1uf2A:
1.0
3a50A-1uf2A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7f OUTER SURFACE
PROTEIN


(Bacillus cereus)
PF05913
(DUF871)
5 ILE A 163
ASN A 122
LEU A 219
ILE A 220
LEU A 199
None
1.10A 3a50A-1x7fA:
undetectable
3a50A-1x7fA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atm HYALURONOGLUCOSAMINI
DASE


(Vespula
vulgaris)
PF01630
(Glyco_hydro_56)
5 ILE A 295
LEU A 319
ILE A 322
ALA A 323
THR A 327
None
1.06A 3a50A-2atmA:
undetectable
3a50A-2atmA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE


(Acidithiobacillus
thiooxidans)
PF00180
(Iso_dh)
5 ILE A  32
ASN A 155
ILE A  92
ALA A  91
LEU A  84
None
1.18A 3a50A-2d4vA:
undetectable
3a50A-2d4vA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiq PUTATIVE TAGATOSE
6-PHOSPHATE KINASE 1


(Escherichia
coli)
PF08013
(Tagatose_6_P_K)
5 ASN A 360
LEU A 295
ILE A 292
ALA A 291
LEU A  25
None
0.99A 3a50A-2fiqA:
undetectable
3a50A-2fiqA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A  45
ASN A 131
ILE A 261
ALA A 260
THR A 265
None
1.16A 3a50A-2hlpA:
undetectable
3a50A-2hlpA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llh NUCLEOPHOSMIN

(Homo sapiens)
PF16276
(NPM1-C)
5 PRO A  38
ILE A  23
LEU A  63
ILE A  60
ALA A  59
None
1.04A 3a50A-2llhA:
undetectable
3a50A-2llhA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM


(Homo sapiens)
PF02985
(HEAT)
PF13646
(HEAT_2)
5 ASN A  22
ILE A  38
ALA A  39
THR A  47
LEU A  55
None
1.09A 3a50A-2pkgA:
undetectable
3a50A-2pkgA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkb RIBONUCLEASE H1

(Homo sapiens)
PF00075
(RNase_H)
5 ILE A 218
LEU A 247
ILE A 187
ALA A 190
THR A 144
None
1.20A 3a50A-2qkbA:
undetectable
3a50A-2qkbA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B


(Saccharomyces
cerevisiae)
PF16846
(Cep3)
5 MET A 174
ILE A 171
LEU A 179
ILE A 182
LEU A 106
None
0.98A 3a50A-2quqA:
1.6
3a50A-2quqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tpt THYMIDINE
PHOSPHORYLASE


(Escherichia
coli)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
5 PRO A 137
ILE A 112
ASN A 140
LEU A 160
ALA A 193
None
1.16A 3a50A-2tptA:
undetectable
3a50A-2tptA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE


(Sphingomonas
elodea)
PF00483
(NTP_transferase)
5 ILE A 209
LEU A   6
ILE A  52
ALA A  50
LEU A 130
None
1.12A 3a50A-2ux8A:
undetectable
3a50A-2ux8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3w DIHYDROFOLATE
REDUCTASE


(Mycobacterium
avium)
PF00186
(DHFR_1)
5 THR A  50
ILE A  24
ASN A  66
ALA A  11
LEU A  32
NDP  A1169 (-3.4A)
NDP  A1169 ( 4.4A)
None
VG9  A1168 ( 3.8A)
VG9  A1168 (-4.7A)
1.17A 3a50A-2w3wA:
undetectable
3a50A-2w3wA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whk MANNAN
ENDO-1,4-BETA-MANNOS
IDASE


(Bacillus
subtilis)
PF02156
(Glyco_hydro_26)
5 PRO A 159
ILE A  63
ILE A 236
ALA A 263
THR A 292
None
1.13A 3a50A-2whkA:
undetectable
3a50A-2whkA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0f WSAF

(Geobacillus
stearothermophilus)
no annotation 5 PRO A 331
ILE A 342
ILE A 260
ALA A 263
LEU A 364
None
1.14A 3a50A-2x0fA:
undetectable
3a50A-2x0fA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B


(Eptatretus
burgeri;
Homo sapiens)
PF11921
(DUF3439)
PF13306
(LRR_5)
PF13855
(LRR_8)
5 ILE A 146
LEU A 131
ALA A 133
THR A 136
LEU A 117
None
1.14A 3a50A-2z65A:
undetectable
3a50A-2z65A:
19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus)
PF00067
(p450)
5 ASN A 194
LEU A 240
ILE A 243
ALA A 244
THR A 248
None
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
0.97A 3a50A-2zbzA:
47.1
3a50A-2zbzA:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus)
PF00067
(p450)
5 ILE A  96
LEU A 240
ILE A 243
ALA A 244
THR A 248
HEM  A 413 (-4.0A)
HEM  A 413 ( 4.5A)
VDX  A 501 (-4.2A)
HEM  A 413 (-3.5A)
HEM  A 413 (-3.2A)
0.54A 3a50A-2zbzA:
47.1
3a50A-2zbzA:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C


(Sulfurisphaera
tokodaii)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 THR C  75
ILE C  25
LEU C  18
ILE C  14
LEU C  34
None
1.11A 3a50A-3aizC:
undetectable
3a50A-3aizC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR-SORTING
PROTEIN SNF8


(Homo sapiens)
PF04157
(EAP30)
5 ILE A 105
LEU A 151
ILE A 148
ALA A 147
LEU A 124
None
1.06A 3a50A-3cuqA:
undetectable
3a50A-3cuqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1


(Drosophila
melanogaster)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ILE A  15
ILE A 327
ALA A 323
THR A 316
LEU A 296
FAD  A 500 (-4.8A)
None
None
None
None
1.15A 3a50A-3dh9A:
undetectable
3a50A-3dh9A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME


(Bacillus
subtilis)
PF00067
(p450)
6 MET B  79
ASN B 181
LEU B 230
ILE B 233
ALA B 234
THR B 238
None
None
HEM  B 405 ( 4.6A)
None
HEM  B 405 (-3.5A)
HEM  B 405 (-3.7A)
0.76A 3a50A-3ejbB:
47.2
3a50A-3ejbB:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA


(Aequorea
victoria;
Rattus
norvegicus)
PF01353
(GFP)
PF13499
(EF-hand_7)
5 MET A 354
ASN A 345
LEU A  57
ILE A  54
ALA A  53
None
0.95A 3a50A-3evrA:
undetectable
3a50A-3evrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE


(Rhodopseudomonas
palustris)
PF07992
(Pyr_redox_2)
PF14759
(Reductase_C)
5 THR P  95
LEU P  89
ILE P  32
ALA P   7
THR P 106
None
None
FAD  P 449 ( 4.5A)
FAD  P 449 ( 4.7A)
FAD  P 449 (-4.1A)
1.16A 3a50A-3fg2P:
undetectable
3a50A-3fg2P:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 ILE A 146
LEU A 131
ALA A 133
THR A 136
LEU A 117
None
1.15A 3a50A-3fxiA:
undetectable
3a50A-3fxiA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3j L-LACTATE
DEHYDROGENASE 1


(Staphylococcus
aureus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 150
LEU A 255
ILE A 278
ALA A 246
LEU A 120
None
1.15A 3a50A-3h3jA:
undetectable
3a50A-3h3jA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana)
PF00248
(Aldo_ket_red)
5 PRO A  17
ILE A  46
LEU A  21
ALA A  34
LEU A  65
None
1.18A 3a50A-3h7uA:
undetectable
3a50A-3h7uA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iby FERROUS IRON
TRANSPORT PROTEIN B


(Legionella
pneumophila)
PF02421
(FeoB_N)
5 THR A  22
ILE A 154
LEU A  17
ILE A  88
ALA A 116
None
1.12A 3a50A-3ibyA:
undetectable
3a50A-3ibyA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ics COENZYME A-DISULFIDE
REDUCTASE


(Bacillus
anthracis)
PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 TRP A 459
ILE A 382
ASN A 186
LEU A 350
ILE A 349
None
1.14A 3a50A-3icsA:
undetectable
3a50A-3icsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iib PEPTIDASE M28

(Shewanella
amazonensis)
PF04389
(Peptidase_M28)
5 PRO A 125
THR A 124
ILE A 219
ILE A 154
ALA A 155
None
0.90A 3a50A-3iibA:
undetectable
3a50A-3iibA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khz PUTATIVE DIPEPTIDASE
SACOL1801


(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
5 PRO A 101
ILE A 446
ILE A 121
ALA A 122
THR A 455
None
1.21A 3a50A-3khzA:
undetectable
3a50A-3khzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 CUBILIN

(Homo sapiens)
PF00431
(CUB)
5 PRO B1179
LEU B1085
ILE B1086
ALA B1087
LEU B1120
None
1.10A 3a50A-3kq4B:
undetectable
3a50A-3kq4B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myu HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37


(Mycoplasma
genitalium)
PF06646
(Mycoplasma_p37)
5 ILE A  67
ASN A  37
LEU A  59
ILE A 324
ALA A 323
None
1.02A 3a50A-3myuA:
undetectable
3a50A-3myuA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myu HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37


(Mycoplasma
genitalium)
PF06646
(Mycoplasma_p37)
5 ILE A  67
ASN A  72
LEU A  59
ILE A 324
ALA A 323
None
1.09A 3a50A-3myuA:
undetectable
3a50A-3myuA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE


(Listeria
monocytogenes)
PF02350
(Epimerase_2)
5 THR A  36
ILE A   9
ILE A  86
ALA A 109
LEU A 117
None
1.07A 3a50A-3ot5A:
undetectable
3a50A-3ot5A:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r9b CYTOCHROME P450
164A2


(Mycolicibacterium
smegmatis)
PF00067
(p450)
5 LEU A 252
ILE A 255
ALA A 256
THR A 260
LEU A 184
HEM  A 501 ( 4.5A)
D12  A 509 ( 4.1A)
HEM  A 501 ( 3.5A)
HEM  A 501 (-3.4A)
D12  A 509 ( 4.3A)
0.94A 3a50A-3r9bA:
48.5
3a50A-3r9bA:
39.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV


(Dichelobacter
nodosus)
PF00082
(Peptidase_S8)
5 ILE A 309
ASN A 174
LEU A 301
ILE A 291
ALA A 294
None
1.06A 3a50A-3ti7A:
undetectable
3a50A-3ti7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE


(Trypanosoma
cruzi)
PF00233
(PDEase_I)
5 PRO A 389
ILE A 592
LEU A 383
ALA A 519
THR A 581
None
1.16A 3a50A-3v94A:
undetectable
3a50A-3v94A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII


(Pseudoxanthomonas
mexicana)
PF10459
(Peptidase_S46)
5 ILE A  53
LYS A  25
LEU A  34
ILE A  37
ALA A  38
None
1.12A 3a50A-3wonA:
2.3
3a50A-3wonA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei)
PF08543
(Phos_pyr_kin)
5 PRO A 148
ILE A 145
LEU A 235
ILE A 248
ALA A 247
None
1.05A 3a50A-3zs7A:
undetectable
3a50A-3zs7A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3


(Saccharomyces
cerevisiae)
no annotation 5 ILE A 135
LEU A 160
ILE A 156
ALA A 159
LEU A 105
None
1.21A 3a50A-4a3tA:
undetectable
3a50A-4a3tA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1


(Bos taurus)
PF04916
(Phospholip_B)
5 THR A 107
LEU A 102
ILE A  81
ALA A  63
LEU B 545
None
1.20A 3a50A-4bwcA:
2.0
3a50A-4bwcA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN


(Bifidobacterium
animalis)
PF01547
(SBP_bac_1)
5 PRO A 301
MET A 150
ILE A 187
ALA A 188
LEU A 179
None
1.18A 3a50A-4c1tA:
undetectable
3a50A-4c1tA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE


(Bacillus
circulans)
PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C)
5 PRO A 356
LEU A 346
ALA A 387
THR A 385
LEU A  69
None
1.20A 3a50A-4cgtA:
undetectable
3a50A-4cgtA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee9 ENDOGLUCANASE

(uncultured
bacterium)
PF00150
(Cellulase)
5 ILE A 117
ASN A   8
LEU A  55
ALA A  68
LEU A  75
None
1.08A 3a50A-4ee9A:
undetectable
3a50A-4ee9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN


(Ochrobactrum
sp. T63)
PF00561
(Abhydrolase_1)
5 THR A 126
ILE A 107
ALA A  81
THR A  85
LEU A  28
None
1.20A 3a50A-4g8dA:
undetectable
3a50A-4g8dA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium)
PF01048
(PNP_UDP_1)
5 PRO A  77
ILE A  19
LEU A  85
ILE A  49
ALA A  60
None
1.16A 3a50A-4glfA:
undetectable
3a50A-4glfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2y RGECO1

(Discosoma sp.;
Gallus gallus;
Rattus
norvegicus)
PF01353
(GFP)
PF13499
(EF-hand_7)
5 MET A 354
ASN A 345
LEU A  56
ILE A  53
ALA A  52
None
1.00A 3a50A-4i2yA:
undetectable
3a50A-4i2yA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN


(Saccharomyces
cerevisiae)
PF00248
(Aldo_ket_red)
5 PRO A  34
ILE A  65
LEU A  38
ALA A  53
LEU A  84
None
1.22A 3a50A-4ijrA:
undetectable
3a50A-4ijrA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis)
PF00724
(Oxidored_FMN)
5 THR A  66
ILE A 185
LEU A 112
ILE A  85
ALA A 173
None
1.09A 3a50A-4m5pA:
undetectable
3a50A-4m5pA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otm SERINE/THREONINE-PRO
TEIN KINASE GCN2


(Saccharomyces
cerevisiae)
PF12745
(HGTP_anticodon2)
5 ILE A1627
LEU A1644
ILE A1655
ALA A1642
LEU A1601
None
1.14A 3a50A-4otmA:
undetectable
3a50A-4otmA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Neisseria
meningitidis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
6 ASN A  51
LEU A  13
ILE A 106
ALA A 107
THR A 111
LEU A  34
None
1.29A 3a50A-4ppzA:
undetectable
3a50A-4ppzA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhi UNCHARACTERIZED
PROTEIN MJ1213


(Methanocaldococcus
jannaschii)
PF01435
(Peptidase_M48)
5 THR A  14
ILE A  29
ILE A  66
ALA A  39
LEU A  55
None
1.06A 3a50A-4qhiA:
undetectable
3a50A-4qhiA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN


(synthetic
construct)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8)
5 ILE A 216
ASN A 162
LEU A 195
ALA A 221
LEU A 231
None
0.94A 3a50A-4r5cA:
undetectable
3a50A-4r5cA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens)
no annotation 5 ILE C 248
ASN C 185
ILE C 228
ALA C 229
LEU C 269
None
1.02A 3a50A-4rwtC:
undetectable
3a50A-4rwtC:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens)
no annotation 5 THR C 218
ILE C 248
ASN C 185
ILE C 228
LEU C 269
None
0.84A 3a50A-4rwtC:
undetectable
3a50A-4rwtC:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN C CHAIN

(Glossoscolex
paulistus)
PF00042
(Globin)
5 ILE C 114
ASN C  74
LEU C 142
ILE C 145
ALA C 146
HEM  C 201 (-3.6A)
None
HEM  C 201 (-4.8A)
None
None
1.13A 3a50A-4u8uC:
undetectable
3a50A-4u8uC:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsr ALR3699 PROTEIN

(Nostoc sp. PCC
7120)
no annotation 5 THR B 347
ILE B 337
LEU B 279
ALA B 281
THR B 283
None
1.21A 3a50A-4xsrB:
undetectable
3a50A-4xsrB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfv VIOF

(Providencia
alcalifaciens)
PF00551
(Formyl_trans_N)
5 ILE A  72
ASN A  98
LEU A 166
ILE A 169
LEU A  89
None
1.18A 3a50A-4yfvA:
undetectable
3a50A-4yfvA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)


(Homo sapiens)
no annotation 5 ILE A 399
ASN A 336
ILE A 379
ALA A 380
LEU A 420
None
GOL  A 505 (-4.2A)
None
GOL  A 502 (-3.6A)
None
0.98A 3a50A-4z79A:
undetectable
3a50A-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)


(Homo sapiens)
no annotation 5 THR A 369
ILE A 399
ASN A 336
ILE A 379
LEU A 420
None
None
GOL  A 505 (-4.2A)
None
None
0.79A 3a50A-4z79A:
undetectable
3a50A-4z79A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)


(Homo sapiens)
no annotation 5 ILE A 399
ASN A 201
ILE A 379
ALA A 380
LEU A 420
None
NI  A 509 (-4.0A)
None
None
None
0.92A 3a50A-4z8gA:
undetectable
3a50A-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)


(Homo sapiens)
no annotation 5 THR A 369
ILE A 399
ASN A 201
ILE A 379
LEU A 420
None
None
NI  A 509 (-4.0A)
None
None
0.76A 3a50A-4z8gA:
undetectable
3a50A-4z8gA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
5 ILE G1399
ASN G1201
ILE G1379
ALA G1380
LEU G1420
None
1.02A 3a50A-4z94G:
undetectable
3a50A-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA


(Homo sapiens)
PF00626
(Gelsolin)
5 THR G1369
ILE G1399
ASN G1201
ILE G1379
LEU G1420
None
0.82A 3a50A-4z94G:
undetectable
3a50A-4z94G:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztb PROTEASE NSP2

(Chikungunya
virus)
PF01707
(Peptidase_C9)
5 ASN A 110
LEU A  13
ILE A  51
ALA A  47
LEU A  60
None
1.02A 3a50A-4ztbA:
undetectable
3a50A-4ztbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0n PYRUVATE, PHOSPHATE
DIKINASE REGULATORY
PROTEIN,
CHLOROPLASTIC


(Zea mays)
PF03618
(Kinase-PPPase)
5 THR A 272
ILE A 289
LEU A 306
ALA A 403
LEU A 339
None
1.04A 3a50A-5d0nA:
undetectable
3a50A-5d0nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fai RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE
NEP1


(Homo sapiens)
PF03587
(EMG1)
5 ILE A 118
ASN A  65
LEU A 140
THR A 124
LEU A  92
None
UNX  A 304 ( 4.1A)
None
None
None
1.09A 3a50A-5faiA:
undetectable
3a50A-5faiA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj8 ACYL-COA
DEHYDROGENASE TYPE 2
DOMAIN PROTEIN


(Alicyclobacillus
acidocaldarius)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2)
5 THR A  58
ILE A  97
LYS A  50
THR A 165
LEU A 170
None
0.98A 3a50A-5gj8A:
1.1
3a50A-5gj8A:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
5 LYS A 180
ASN A 181
ILE A 235
ALA A 236
THR A 240
None
None
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
1.10A 3a50A-5gnmA:
56.7
3a50A-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
7 PRO A  83
THR A  84
MET A  86
ILE A  88
ILE A 235
ALA A 236
LEU A 387
None
None
None
HEM  A 501 ( 4.4A)
None
HEM  A 501 (-3.6A)
None
0.85A 3a50A-5gnmA:
56.7
3a50A-5gnmA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gnm VITAMIN D(3)
25-HYDROXYLASE


(Pseudonocardia
autotrophica)
PF00067
(p450)
8 PRO A  83
THR A  84
MET A  86
ILE A  88
LEU A 232
ILE A 235
ALA A 236
THR A 240
None
None
None
HEM  A 501 ( 4.4A)
HEM  A 501 ( 4.7A)
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.7A)
0.64A 3a50A-5gnmA:
56.7
3a50A-5gnmA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwi GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE


(Saccharomyces
cerevisiae)
PF04752
(ChaC)
5 ILE A  17
ASN A 131
LEU A 204
ILE A  93
LEU A  11
None
1.21A 3a50A-5hwiA:
undetectable
3a50A-5hwiA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jen ANTI-SIGMA-V FACTOR
RSIV


(Bacillus
subtilis)
PF11738
(DUF3298)
PF13739
(DUF4163)
5 PRO A  99
THR A  98
ILE A 162
ASN A 114
LEU A 124
None
0.76A 3a50A-5jenA:
undetectable
3a50A-5jenA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7


(Zea mays)
PF00248
(Aldo_ket_red)
5 PRO A  14
ILE A  43
LEU A  18
ALA A  31
LEU A  62
None
1.19A 3a50A-5jh1A:
undetectable
3a50A-5jh1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joq LMO2184 PROTEIN

(Listeria
monocytogenes)
PF01497
(Peripla_BP_2)
5 PRO A  66
ILE A  47
LEU A  51
ALA A 143
LEU A 150
None
1.15A 3a50A-5joqA:
undetectable
3a50A-5joqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage)
PF12708
(Pectate_lyase_3)
5 ILE A 161
ASN A 220
LEU A 186
ILE A 183
LEU A 138
None
1.18A 3a50A-5jseA:
undetectable
3a50A-5jseA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE


(Porphyromonas
gingivalis)
PF10459
(Peptidase_S46)
5 ILE A 259
ASN A  83
LEU A 700
ILE A 703
LEU A  79
None
1.19A 3a50A-5jwfA:
undetectable
3a50A-5jwfA:
22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l94 CYTOCHROME P450

(Bacillus
megaterium)
PF00067
(p450)
6 ILE A  85
LYS A 187
LEU A 238
ILE A 241
ALA A 242
THR A 246
HEM  A 501 (-4.4A)
None
HEM  A 501 (-4.4A)
TES  A 502 (-4.0A)
HEM  A 501 (-3.5A)
HEM  A 501 (-3.4A)
0.47A 3a50A-5l94A:
49.2
3a50A-5l94A:
34.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxv SCAFFOLDIN C

(Ruminococcus
flavefaciens)
PF00963
(Cohesin)
5 ILE A  37
LEU A 108
ILE A  58
ALA A  59
THR A  61
None
0.97A 3a50A-5lxvA:
undetectable
3a50A-5lxvA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom 39S RIBOSOMAL
PROTEIN L22,
MITOCHONDRIAL


(Homo sapiens)
PF00237
(Ribosomal_L22)
5 PRO T 183
ILE T 142
LEU T 178
ALA T 124
LEU T 103
None
1.15A 3a50A-5oomT:
undetectable
3a50A-5oomT:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE


(Pseudomonas
putida)
PF00171
(Aldedh)
5 ILE A 134
ASN A  45
LEU A  35
ILE A  76
ALA A  79
None
1.18A 3a50A-5ucdA:
undetectable
3a50A-5ucdA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3


(Pseudomonas
aeruginosa)
PF09615
(Cas_Csy3)
5 ILE C 181
LEU C 214
ILE C 218
ALA C 158
LEU C 283
None
1.15A 3a50A-5uz9C:
undetectable
3a50A-5uz9C:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf4 UNCHARACTERIZED
PROTEIN


(Thermus
aquaticus)
PF03781
(FGE-sulfatase)
5 ILE A 212
ASN A 218
LEU A 316
ALA A 322
LEU A 360
None
1.19A 3a50A-5vf4A:
undetectable
3a50A-5vf4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa)
PF16957
(Mal_decarbox_Al)
5 MET A 420
ILE A 268
ALA A 266
THR A 296
LEU A 291
None
1.18A 3a50A-5vj1A:
undetectable
3a50A-5vj1A:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE


(Bacteroides
thetaiotaomicron)
no annotation 5 ILE A 586
ASN A 413
LEU A 447
ILE A 511
ALA A 513
None
1.21A 3a50A-5xxoA:
undetectable
3a50A-5xxoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei)
no annotation 5 ILE A 107
LEU A 252
ILE A 255
ALA A 256
THR A 260
HEM  A 501 (-4.2A)
HEM  A 501 ( 4.6A)
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.7A)
0.80A 3a50A-5ysmA:
39.8
3a50A-5ysmA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD


(Bacillus
thuringiensis)
no annotation 5 PRO A 286
MET A 288
ILE A 290
ILE A 218
ALA A 219
None
1.08A 3a50A-6bwcA:
undetectable
3a50A-6bwcA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE


(Medicago
truncatula)
no annotation 5 ILE A 455
LEU A 390
ILE A 473
ALA A 474
LEU A 429
None
1.15A 3a50A-6cczA:
undetectable
3a50A-6cczA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ep3 -

(-)
no annotation 5 ASN A  65
LEU A  54
ILE A  51
ALA A  50
LEU A  36
None
1.08A 3a50A-6ep3A:
2.0
3a50A-6ep3A:
undetectable