SIMILAR PATTERNS OF AMINO ACIDS FOR 3A3Y_A_OBNA6000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		5 PHE L 105
GLY L 106
ALA L 391
PHE L 254
THR L 385
 H2S  L 502 (-4.7A)
None
None
None
None
 1.41A 3a3yA-1cc1L:
0.0		 3a3yA-1cc1L:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 GLY A 264
VAL A 319
ALA A 318
LEU A 310
THR A 406
 None
 1.07A 3a3yA-1cg4A:
undetectable		 3a3yA-1cg4A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 342
PHE A 345
PHE A 296
LEU A 297
THR A 347
 None
 1.19A 3a3yA-1crlA:
undetectable		 3a3yA-1crlA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyx CYOA

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		5 GLY A 205
ALA A 208
PHE A 174
PHE A 163
LEU A 193
 None
 1.39A 3a3yA-1cyxA:
undetectable		 3a3yA-1cyxA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 GLU A  74
GLY A  98
PHE A 117
LEU A 120
THR A 113
 None
 1.34A 3a3yA-1dkrA:
0.5		 3a3yA-1dkrA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 GLY B 159
ALA B 197
PHE B 195
LEU B 183
ARG B 511
 None
 1.35A 3a3yA-1e9yB:
0.0		 3a3yA-1e9yB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 GLY B 160
ALA B 197
PHE B 195
LEU B 183
ARG B 511
 None
 1.37A 3a3yA-1e9yB:
0.0		 3a3yA-1e9yB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		5 GLU A 151
PHE B 428
PHE B 431
LEU A 185
ARG B 350
 None
 1.28A 3a3yA-1gxsA:
undetectable		 3a3yA-1gxsA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 GLU A 102
GLY A 304
ALA A 306
LEU A  33
THR A 148
 None
HIS  A 450 ( 4.2A)
HIS  A 450 ( 4.0A)
None
None
 1.33A 3a3yA-1httA:
undetectable		 3a3yA-1httA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		5 PHE A  19
GLY A 448
ALA A  89
PHE A  25
LEU A 490
 None
 1.29A 3a3yA-1hxjA:
undetectable		 3a3yA-1hxjA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i51 CASPASE-7 SUBUNIT
P20

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 PHE A 182
ALA A  96
PHE A 101
PHE A 106
LEU A 104
 None
 1.33A 3a3yA-1i51A:
2.4		 3a3yA-1i51A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 PHE A 178
GLY A 198
ALA A 203
PHE A 201
LEU A 295
 None
 1.34A 3a3yA-1j3uA:
undetectable		 3a3yA-1j3uA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 PHE A 182
ALA A  96
PHE A 101
PHE A 106
LEU A 104
 None
 1.37A 3a3yA-1k86A:
2.6		 3a3yA-1k86A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 GLU A 495
VAL A 374
ALA A 373
PHE A 463
THR A 414
 None
 1.24A 3a3yA-1m53A:
undetectable		 3a3yA-1m53A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mum 2-METHYLISOCITRATE
LYASE

(Escherichia
coli) 		PF13714
(PEP_mutase) 		5 GLY A  24
ALA A  41
PHE A 186
LEU A 208
ARG A 158
 None
None
None
None
MG  A1001 ( 4.8A)
 1.20A 3a3yA-1mumA:
1.2		 3a3yA-1mumA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppy ASPARTATE
1-DECARBOXYLASE
PRECURSOR

(Escherichia
coli) 		PF02261
(Asp_decarbox) 		5 GLY A  65
ALA A  62
PHE A  32
PHE A 108
LEU A  10
 None
 1.39A 3a3yA-1ppyA:
undetectable		 3a3yA-1ppyA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		5 GLY A  16
VAL A  12
ALA A  82
PHE A  78
PHE A  75
 None
 1.21A 3a3yA-1qb4A:
undetectable		 3a3yA-1qb4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		5 GLU A 429
VAL A 441
ALA A 442
LEU A 114
ARG A 116
 None
 1.37A 3a3yA-1sjpA:
undetectable		 3a3yA-1sjpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		5 PHE A  25
GLY A 449
ALA A  95
PHE A  31
LEU A 491
 None
 1.12A 3a3yA-1v02A:
undetectable		 3a3yA-1v02A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 PHE A 458
GLY A 456
ALA A  52
PHE A 425
LEU A 444
 None
 1.33A 3a3yA-2ag1A:
2.0		 3a3yA-2ag1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 GLY A  51
VAL A 112
ALA A 108
PHE A  98
LEU A  96
 SAI  A1300 (-3.8A)
SAI  A1300 (-3.9A)
None
None
None
 1.31A 3a3yA-2avnA:
undetectable		 3a3yA-2avnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 GLU A  95
GLY A 433
ALA A 405
LEU A 499
ARG A 498
 None
 1.35A 3a3yA-2aw5A:
undetectable		 3a3yA-2aw5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 PHE A 125
GLY A 126
VAL A 130
ALA A 131
LEU A 163
 None
 1.35A 3a3yA-2douA:
undetectable		 3a3yA-2douA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7g RHA04620, PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF02909
(TetR_C) 		5 GLU A  65
VAL A 135
ALA A 138
PHE A 186
LEU A 190
 None
 1.25A 3a3yA-2g7gA:
undetectable		 3a3yA-2g7gA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 GLU A  57
GLY A  67
VAL A 145
PHE A 132
PHE A 350
 None
None
None
None
PE4  A4124 (-4.2A)
 1.29A 3a3yA-2gouA:
undetectable		 3a3yA-2gouA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		5 GLY A 119
VAL A 129
ALA A 130
PHE A 122
PHE A 188
 None
 1.35A 3a3yA-2inpA:
undetectable		 3a3yA-2inpA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 PHE A  80
VAL A  38
ALA A  41
LEU A 268
THR A  23
 None
None
None
NAP  A   1 (-4.2A)
None
 1.17A 3a3yA-2ipjA:
undetectable		 3a3yA-2ipjA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jft SER-THR PHOSPHATASE
MSPP

(Mycolicibacterium
smegmatis) 		PF13672
(PP2C_2) 		5 PHE A  37
GLY A  41
ALA A  23
LEU A 159
THR A  47
 None
 1.21A 3a3yA-2jftA:
undetectable		 3a3yA-2jftA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		5 GLU G 162
GLY G 246
ALA G 251
PHE G 244
LEU G 172
 None
 1.32A 3a3yA-2nzuG:
3.0		 3a3yA-2nzuG:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens) 		PF12849
(PBP_like_2) 		5 GLU A 162
VAL A 185
ALA A 186
PHE A 172
PHE A 151
 None
EDO  A 906 ( 4.1A)
EDO  A 906 (-3.4A)
None
None
 1.38A 3a3yA-2q9tA:
undetectable		 3a3yA-2q9tA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ql7 CASPASE-7

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 PHE A 182
ALA A  96
PHE A 101
PHE A 106
LEU A 104
 None
 1.37A 3a3yA-2ql7A:
2.5		 3a3yA-2ql7A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT

(Arabidopsis
thaliana) 		PF00503
(G-alpha) 		5 GLU A 325
VAL A 299
PHE A 292
PHE A 289
ARG A 352
 None
 1.31A 3a3yA-2xtzA:
undetectable		 3a3yA-2xtzA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		5 GLU A 211
GLY A 573
ALA A 570
LEU A 580
ARG A 582
 None
 1.29A 3a3yA-3agrA:
undetectable		 3a3yA-3agrA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bnw RIBOFLAVIN KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01687
(Flavokinase) 		5 GLU A 168
GLY A  14
VAL A  16
ALA A 106
PHE A 157
 None
 1.09A 3a3yA-3bnwA:
undetectable		 3a3yA-3bnwA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 GLU A 241
PHE A  42
VAL A 302
ALA A 105
LEU A 316
 None
MLZ  A  45 ( 4.4A)
None
None
None
 1.32A 3a3yA-3e3xA:
undetectable		 3a3yA-3e3xA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		5 GLU A 117
GLY A 216
ALA A 220
LEU A  67
ARG A  69
 None
 1.40A 3a3yA-3f7wA:
undetectable		 3a3yA-3f7wA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0u PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		5 GLU A 235
GLY A 153
ALA A 121
LEU A 160
ARG A 162
 None
 1.25A 3a3yA-3h0uA:
undetectable		 3a3yA-3h0uA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1a SPECTINOMYCIN
PHOSPHOTRANSFERASE

(Legionella
pneumophila) 		PF01636
(APH) 		5 GLU A 240
GLY A 248
VAL A 253
PHE A 263
LEU A 121
 None
 1.04A 3a3yA-3i1aA:
undetectable		 3a3yA-3i1aA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4e UNCHARACTERIZED
PEPTIDASE LMO0363

(Listeria
monocytogenes) 		PF03575
(Peptidase_S51) 		5 GLU A  21
PHE A  17
ALA A  47
PHE A  10
THR A  85
 None
 1.39A 3a3yA-3l4eA:
2.8		 3a3yA-3l4eA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvg CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		5 GLY A1294
VAL A1261
PHE A1296
PHE A1327
LEU A1323
 None
 0.99A 3a3yA-3lvgA:
undetectable		 3a3yA-3lvgA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt1 PUTATIVE
CARBOXYNORSPERMIDINE
DECARBOXYLASE
PROTEIN

(Sinorhizobium
meliloti) 		PF00278
(Orn_DAP_Arg_deC) 		5 PHE A  39
GLY A 232
ALA A  32
PHE A  45
THR A  56
 None
SO4  A 401 (-3.4A)
None
None
None
 1.33A 3a3yA-3mt1A:
undetectable		 3a3yA-3mt1A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myr HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA
NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Allochromatium
vinosum) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 GLY B1170
ALA A  54
LEU B1546
THR B1011
ARG B1547
 None
 1.35A 3a3yA-3myrB:
undetectable		 3a3yA-3myrB:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		9 GLU A 312
PHE A 316
GLY A 319
VAL A 322
ALA A 323
PHE A 783
PHE A 786
LEU A 793
ARG A 880
 None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
None
None
OBN  A   1 (-3.7A)
 0.74A 3a3yA-3n23A:
55.3		 3a3yA-3n23A:
85.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		9 GLU A 312
PHE A 316
GLY A 319
VAL A 322
ALA A 323
PHE A 786
LEU A 793
THR A 797
ARG A 880
 None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 (-2.8A)
OBN  A   1 (-3.7A)
 0.48A 3a3yA-3n23A:
55.3		 3a3yA-3n23A:
85.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLU A 192
GLY A 333
ALA A 219
PHE A  39
THR A  34
 None
 1.28A 3a3yA-3oytA:
undetectable		 3a3yA-3oytA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9j SEPTUM
SITE-DETERMINING
PROTEIN MIND

(Escherichia
coli) 		PF01656
(CbiA) 		5 GLU A 244
GLY A 236
VAL A 217
LEU A 179
THR A  18
 None
None
ADP  A 261 (-4.4A)
None
ADP  A 261 (-3.8A)
 1.38A 3a3yA-3r9jA:
3.2		 3a3yA-3r9jA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		5 GLY A 244
ALA A 272
PHE A 270
LEU A 259
ARG A 260
 None
 1.15A 3a3yA-3t8lA:
undetectable		 3a3yA-3t8lA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbb SMALL LACCASE,
OXIDOREDUCTASE

(Streptomyces
viridosporus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PHE A 228
VAL A 252
ALA A 236
PHE A 266
PHE A 216
 None
 1.13A 3a3yA-3tbbA:
undetectable		 3a3yA-3tbbA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 GLY A 331
VAL A 293
ALA A 414
PHE A 380
ARG A 479
 None
 1.35A 3a3yA-3ummA:
2.0		 3a3yA-3ummA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		5 GLU A 344
GLY A 364
VAL A 263
ALA A 266
PHE A 257
 None
 1.29A 3a3yA-3vz0A:
undetectable		 3a3yA-3vz0A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN

(unidentified
prokaryotic
organism) 		PF12849
(PBP_like_2) 		5 GLU A 161
VAL A 186
ALA A 187
PHE A 171
PHE A 150
 GOL  A 402 ( 4.6A)
None
None
None
None
 1.37A 3a3yA-3w9vA:
undetectable		 3a3yA-3w9vA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		5 PHE A 323
ALA A 252
PHE A 275
LEU A 295
THR A 254
 None
TRS  A 503 ( 4.1A)
None
None
None
 1.22A 3a3yA-3wmyA:
undetectable		 3a3yA-3wmyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azd ASPARTATE
1-DECARBOXYLASE

(Escherichia
coli) 		PF02261
(Asp_decarbox) 		5 GLY A  65
ALA A  62
PHE A  32
PHE A 108
LEU A  10
 None
 1.41A 3a3yA-4azdA:
undetectable		 3a3yA-4azdA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b61 ALGINATE PRODUCTION
PROTEIN ALGE

(Pseudomonas
aeruginosa) 		PF13372
(Alginate_exp) 		5 PHE A 370
GLY A 367
VAL A 397
PHE A 401
THR A 381
 None
 1.36A 3a3yA-4b61A:
undetectable		 3a3yA-4b61A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 PHE B 223
GLY A 354
VAL B 231
PHE B 248
LEU B 117
 None
 1.40A 3a3yA-4cakB:
undetectable		 3a3yA-4cakB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLU A 435
GLY A 357
ALA A 332
PHE A 301
LEU A 307
 None
None
MG  A1495 ( 3.9A)
None
None
 1.21A 3a3yA-4cnsA:
undetectable		 3a3yA-4cnsA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLU A 435
GLY A 357
ALA A 332
PHE A 301
LEU A 307
 None
 1.20A 3a3yA-4cntA:
undetectable		 3a3yA-4cntA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 GLY A 314
ALA A 456
PHE A 321
THR A 196
ARG A 490
 0T3  A 602 ( 3.3A)
HEM  A 601 ( 3.8A)
None
None
None
 1.33A 3a3yA-4fdhA:
undetectable		 3a3yA-4fdhA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2b SECRETED EFFECTOR
PROTEIN SSEI

(Salmonella
enterica) 		PF15645
(Tox-PLDMTX) 		5 PHE A 194
ALA A 218
PHE A 230
PHE A 188
LEU A 161
 None
 1.40A 3a3yA-4g2bA:
undetectable		 3a3yA-4g2bA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 10
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8

(Thermus
thermophilus) 		no annotation 5 GLU H 130
ALA H 142
PHE H 137
PHE J  69
LEU H 153
 None
 1.40A 3a3yA-4he8H:
undetectable		 3a3yA-4he8H:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLU A 215
PHE A 223
ALA A 194
PHE A 197
LEU A 256
 None
 1.35A 3a3yA-4i3gA:
2.4		 3a3yA-4i3gA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l39 4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 GLU A 329
PHE A 332
GLY A 333
PHE A 349
LEU A 372
 MG  A 601 (-3.7A)
None
None
None
None
 1.35A 3a3yA-4l39A:
undetectable		 3a3yA-4l39A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2r ALPHA-L-ARABINOFURAN
OSIDASE UMABF62A

(Ustilago maydis) 		PF03664
(Glyco_hydro_62) 		5 PHE A 157
ALA A  86
PHE A 109
LEU A 129
THR A  88
 None
AHR  A 403 ( 3.9A)
None
None
None
 1.25A 3a3yA-4n2rA:
undetectable		 3a3yA-4n2rA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 GLU A  63
VAL A 169
PHE A 193
LEU A  71
ARG A  70
 None
 1.31A 3a3yA-4o6rA:
2.1		 3a3yA-4o6rA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8o ALPHA-L-ARABINOFURAN
OSIDASE

(Streptomyces
thermoviolaceus) 		PF03664
(Glyco_hydro_62) 		5 PHE A 210
ALA A 139
PHE A 162
LEU A 182
THR A 141
 None
AHR  A 402 ( 3.7A)
None
None
None
 1.20A 3a3yA-4o8oA:
undetectable		 3a3yA-4o8oA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PHE A 343
GLY A 281
VAL A 277
ALA A 279
LEU A 363
 None
 1.40A 3a3yA-4okdA:
undetectable		 3a3yA-4okdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD

(Homo sapiens) 		PF02661
(Fic) 		5 GLU A 328
PHE A 309
GLY A 307
PHE A 365
LEU A 359
 None
 1.38A 3a3yA-4u0zA:
undetectable		 3a3yA-4u0zA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		5 GLU A 132
GLY A 180
VAL A 176
ALA A 175
PHE A 142
 None
 1.14A 3a3yA-4uedA:
undetectable		 3a3yA-4uedA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		5 GLU A 132
GLY A 180
VAL A 176
PHE A 142
THR A 167
 None
 1.08A 3a3yA-4uedA:
undetectable		 3a3yA-4uedA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PHE A 230
VAL A 254
ALA A 238
PHE A 268
PHE A 218
 None
 1.10A 3a3yA-4w1tA:
undetectable		 3a3yA-4w1tA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		5 GLY A  51
VAL A 224
PHE A  54
LEU A 220
ARG A 207
 None
 1.32A 3a3yA-4wlpA:
undetectable		 3a3yA-4wlpA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLU A 189
GLY A 329
ALA A 216
PHE A  39
THR A  34
 None
 1.34A 3a3yA-4xoxA:
undetectable		 3a3yA-4xoxA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zck GTP-BINDING PROTEIN
TYPA/BIPA

(Escherichia
coli) 		PF00679
(EFG_C) 		5 GLU A 517
PHE A 318
VAL A 578
ALA A 381
LEU A 592
 None
 1.35A 3a3yA-4zckA:
undetectable		 3a3yA-4zckA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Sphaerobacter
thermophilus) 		PF13458
(Peripla_BP_6) 		5 GLU A  98
GLY A 361
ALA A 337
PHE A 351
LEU A 106
 None
 1.13A 3a3yA-4zpjA:
2.5		 3a3yA-4zpjA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zvs CASPASE-7

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 PHE A 182
ALA A  96
PHE A 101
PHE A 106
LEU A 104
 None
 1.37A 3a3yA-4zvsA:
2.5		 3a3yA-4zvsA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f GENOME POLYPHUMAN
SAFFOLD VIRUS-3 VP3
PROTEIN

(Cardiovirus B) 		PF00073
(Rhv) 		5 PHE B 115
GLY B 123
PHE B 125
LEU B  78
THR B  73
 None
 1.39A 3a3yA-5a8fB:
undetectable		 3a3yA-5a8fB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		5 GLY C 270
ALA C 401
PHE C 496
LEU C 312
THR C 309
 None
 1.24A 3a3yA-5aa5C:
undetectable		 3a3yA-5aa5C:
18.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		6 VAL A 329
ALA A 330
PHE A 793
LEU A 800
THR A 804
ARG A 887
 None
 0.85A 3a3yA-5aw4A:
64.7		 3a3yA-5aw4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfc VP3

(Cardiovirus B) 		PF00073
(Rhv) 		5 PHE B 115
GLY B 123
PHE B 125
LEU B  78
THR B  73
 None
 1.39A 3a3yA-5cfcB:
undetectable		 3a3yA-5cfcB:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE

(Salmonella
enterica) 		PF02664
(LuxS) 		5 GLU A  57
PHE A  87
VAL A  19
ALA A  18
PHE A  40
 None
 1.30A 3a3yA-5e68A:
undetectable		 3a3yA-5e68A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		5 GLU A 132
GLY A 180
VAL A 176
ALA A 175
PHE A 142
 None
 1.12A 3a3yA-5ei3A:
undetectable		 3a3yA-5ei3A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		5 GLU A 132
GLY A 180
VAL A 176
PHE A 142
THR A 167
 None
 1.07A 3a3yA-5ei3A:
undetectable		 3a3yA-5ei3A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eno MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 PHE A 628
VAL A 142
ALA A 286
PHE A 178
PHE A 615
 None
 1.39A 3a3yA-5enoA:
undetectable		 3a3yA-5enoA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd3 PROTEIN LIN-54
HOMOLOG

(Homo sapiens) 		PF03638
(TCR) 		5 PHE A 540
GLY A 543
PHE A 579
LEU A 572
ARG A 574
 None
 1.32A 3a3yA-5fd3A:
undetectable		 3a3yA-5fd3A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		5 GLU A 297
VAL A 303
ALA A 345
LEU A 334
ARG A 335
 None
 1.36A 3a3yA-5hmqA:
undetectable		 3a3yA-5hmqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		5 GLU A 320
PHE A 391
ALA A 352
PHE A 387
LEU A 328
 None
 1.39A 3a3yA-5j3nA:
undetectable		 3a3yA-5j3nA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		5 VAL A 141
ALA A 152
PHE A 154
PHE A 156
LEU A 168
 None
 1.40A 3a3yA-5jodA:
undetectable		 3a3yA-5jodA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 GLY B 998
VAL B1000
ALA B1001
THR B1021
ARG A 187
 None
 1.27A 3a3yA-5jpnB:
undetectable		 3a3yA-5jpnB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lly DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN

(Idiomarina sp.
A28L) 		no annotation 5 GLY D 361
ALA D 421
PHE D 437
PHE D 416
ARG D 415
 None
 1.41A 3a3yA-5llyD:
undetectable		 3a3yA-5llyD:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mf1 FUSION PROTEIN
HAP2/GCS1

(Chlamydomonas
reinhardtii) 		PF10699
(HAP2-GCS1) 		5 PHE A 163
GLY A 162
PHE A 376
LEU A 391
THR A 212
 None
 1.13A 3a3yA-5mf1A:
undetectable		 3a3yA-5mf1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 GLU A 196
GLY A 186
PHE A 215
PHE A 227
THR A 221
 None
 1.23A 3a3yA-5msyA:
undetectable		 3a3yA-5msyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		5 GLU A 326
GLY A 219
VAL A 101
ALA A 100
LEU A  93
 None
 1.19A 3a3yA-5ny5A:
undetectable		 3a3yA-5ny5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF01977
(UbiD) 		5 GLU A 326
GLY A 219
VAL A 101
ALA A 100
LEU A  93
 None
 1.20A 3a3yA-5o3mA:
undetectable		 3a3yA-5o3mA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uai METHIONYL-TRNA
FORMYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 GLU A  14
GLY A 176
VAL A 155
LEU A 168
THR A 157
 None
 1.27A 3a3yA-5uaiA:
undetectable		 3a3yA-5uaiA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubj ALPHA-L-ARABINOFURAN
OSIDASE AXHA-2

(Aspergillus
nidulans) 		PF03664
(Glyco_hydro_62) 		5 PHE A 172
ALA A 101
PHE A 124
LEU A 144
THR A 103
 None
 1.21A 3a3yA-5ubjA:
undetectable		 3a3yA-5ubjA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 GLU A 435
GLY A 357
ALA A 332
PHE A 301
LEU A 307
 None
 1.21A 3a3yA-5uqcA:
undetectable		 3a3yA-5uqcA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 5 GLU A 506
ALA A 462
PHE A 460
PHE A 449
LEU A 441
 None
 1.22A 3a3yA-5xwyA:
undetectable		 3a3yA-5xwyA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E

(Pseudomonas sp.
AIU 813) 		no annotation 5 GLU A 223
GLY A 233
PHE A 156
LEU A 152
THR A 135
 None
 1.27A 3a3yA-5yb7A:
2.0		 3a3yA-5yb7A:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 PHE A 345
GLY A 346
VAL A 351
ALA A 352
THR A 421
 None
 1.23A 3a3yA-5z06A:
undetectable		 3a3yA-5z06A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1j -

(-) 		no annotation 5 PHE A 174
ALA A 103
PHE A 126
LEU A 146
THR A 105
 None
EDG  A 401 (-3.6A)
None
None
None
 1.21A 3a3yA-6f1jA:
undetectable		 3a3yA-6f1jA:
undetectable