SIMILAR PATTERNS OF AMINO ACIDS FOR 3A3B_A_RBFA191_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ako EXONUCLEASE III

(Escherichia
coli) 		PF03372
(Exo_endo_phos) 		5 VAL A  29
LEU A  68
THR A  69
THR A  35
ILE A   8
 None
 1.13A 3a3bA-1akoA:
undetectable		 3a3bA-1akoA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ble FRUCTOSE PERMEASE

(Bacillus
subtilis) 		PF03830
(PTSIIB_sorb) 		5 SER A  92
ASP A 127
GLN A 126
ALA A 130
THR A 133
 None
 1.11A 3a3bA-1bleA:
undetectable		 3a3bA-1bleA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cee GTP-BINDING RHO-LIKE
PROTEIN

(Homo sapiens) 		PF00071
(Ras) 		5 VAL A   9
CYH A   6
LEU A  79
ALA A 172
ILE A   4
 None
 0.93A 3a3bA-1ceeA:
0.0		 3a3bA-1ceeA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddb PROTEIN (BID)

(Mus musculus) 		PF06393
(BID) 		5 SER A  28
LEU A  25
THR A  31
ALA A 156
THR A 174
 None
 1.13A 3a3bA-1ddbA:
undetectable		 3a3bA-1ddbA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 VAL A1094
THR A1087
ASP A1414
ASN A1024
ILE A1083
 None
 1.01A 3a3bA-1e6yA:
0.0		 3a3bA-1e6yA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 VAL A 364
GLN A 408
ALA A 409
THR A 412
ILE A 375
 None
 1.16A 3a3bA-1f59A:
undetectable		 3a3bA-1f59A:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 CYH A  47
LEU A  49
THR A  50
THR A  71
ILE A 103
 None
 0.39A 3a3bA-1i8dA:
25.0		 3a3bA-1i8dA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 SER A  54
LEU A  56
THR A  57
ASP A  64
ILE A 276
 None
 1.17A 3a3bA-1jedA:
1.9		 3a3bA-1jedA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0r NUSA

(Mycobacterium
tuberculosis) 		PF08529
(NusA_N)
PF13184
(KH_5) 		5 VAL A 168
CYH A 165
SER A 182
LEU A 181
THR A 180
 None
 1.15A 3a3bA-1k0rA:
0.9		 3a3bA-1k0rA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1c CATABOLITE
REPRESSION HPR-LIKE
PROTEIN

(Bacillus
subtilis) 		PF00381
(PTS-HPr) 		5 LEU A  63
THR A  62
GLN A   3
ALA A  65
ASN A  43
 None
 1.03A 3a3bA-1k1cA:
undetectable		 3a3bA-1k1cA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktn 2-DEOXYRIBOSE-5-PHOS
PHATE ALDOLASE

(Escherichia
coli) 		PF01791
(DeoC) 		5 CYH A 129
LEU A 136
ASP A 102
THR A  90
ILE A  94
 None
 1.13A 3a3bA-1ktnA:
undetectable		 3a3bA-1ktnA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 VAL A 179
LEU A 176
ASP A  61
ALA A  64
ILE A  72
 None
 1.16A 3a3bA-1mdfA:
undetectable		 3a3bA-1mdfA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyw ATP-DEPENDENT DNA
HELICASE

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 LEU A 476
ASP A 415
ALA A 419
THR A 422
ILE A 423
 None
 1.23A 3a3bA-1oywA:
undetectable		 3a3bA-1oywA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 SER A 519
LEU A 518
THR A 460
ALA A 360
ASN A 522
 None
 1.22A 3a3bA-1qgdA:
undetectable		 3a3bA-1qgdA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wln AFADIN

(Mus musculus) 		PF00498
(FHA) 		5 VAL A  37
CYH A  62
LEU A  64
THR A  65
THR A  82
 None
 1.21A 3a3bA-1wlnA:
undetectable		 3a3bA-1wlnA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 VAL A 269
SER A 271
THR A 316
ALA A 347
ASN A  81
 None
 1.15A 3a3bA-1wmrA:
undetectable		 3a3bA-1wmrA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 LEU A 486
THR A 487
ALA A 427
THR A 430
ASN A 482
 None
 1.19A 3a3bA-1xjeA:
undetectable		 3a3bA-1xjeA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		5 VAL A  19
CYH A  16
LEU A  77
THR A  78
THR A 163
 None
 1.23A 3a3bA-1y5eA:
undetectable		 3a3bA-1y5eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydm HYPOTHETICAL PROTEIN
YQGN

(Bacillus
subtilis) 		PF01812
(5-FTHF_cyc-lig) 		5 VAL A 173
SER A 153
THR A 151
THR A  56
ILE A  54
 None
 1.21A 3a3bA-1ydmA:
undetectable		 3a3bA-1ydmA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA

(Mycobacterium
tuberculosis) 		PF13184
(KH_5) 		5 VAL A 168
CYH A 165
SER A 182
LEU A 181
THR A 180
 None
 1.14A 3a3bA-2asbA:
undetectable		 3a3bA-2asbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gry KINESIN-LIKE PROTEIN
KIF2

(Homo sapiens) 		PF00225
(Kinesin) 		5 VAL A 411
SER A 427
LEU A 428
THR A 273
ILE A 274
 None
 1.01A 3a3bA-2gryA:
undetectable		 3a3bA-2gryA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j8k NP275-NP276

(Nostoc
punctiforme) 		PF00805
(Pentapeptide) 		5 LEU A 157
THR A 158
ASP A 136
ALA A 155
ILE A 171
 None
 1.15A 3a3bA-2j8kA:
undetectable		 3a3bA-2j8kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		5 LEU A 305
THR A 306
THR A 203
THR A 204
ILE A 268
 None
 1.14A 3a3bA-2jf7A:
undetectable		 3a3bA-2jf7A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbf 60S ACIDIC RIBOSOMAL
PROTEIN P1
60S ACIDIC RIBOSOMAL
PROTEIN P2

(Homo sapiens) 		PF00428
(Ribosomal_60s) 		5 VAL A  21
THR A  22
ASP A  26
ALA A  30
ILE B 126
 None
 1.07A 3a3bA-2lbfA:
undetectable		 3a3bA-2lbfA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbr GAMMA-CRYSTALLIN C

(Homo sapiens) 		PF00030
(Crystall) 		5 CYH A  78
SER A  77
LEU A  25
THR A  20
THR A  18
 None
 1.21A 3a3bA-2nbrA:
undetectable		 3a3bA-2nbrA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 LEU A 163
THR A 164
ALA A 139
THR A 136
ILE A 135
 None
 1.19A 3a3bA-2omvA:
undetectable		 3a3bA-2omvA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg1 DYNEIN LIGHT CHAIN
TCTEX-TYPE

(Drosophila
melanogaster) 		PF03645
(Tctex-1) 		5 CYH E 102
THR E  92
ALA E  65
THR E  41
ILE E  67
 None
 1.14A 3a3bA-2pg1E:
undetectable		 3a3bA-2pg1E:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		5 VAL A  82
LEU A  72
THR A  71
ALA A 223
ILE A 225
 None
 1.07A 3a3bA-2qneA:
undetectable		 3a3bA-2qneA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		5 LEU A 192
THR A 193
ALA A 346
THR A 345
ILE A 348
 None
 1.23A 3a3bA-2vgqA:
undetectable		 3a3bA-2vgqA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus 1) 		PF13365
(Trypsin_2) 		5 VAL A 457
GLN A 567
ALA A 576
THR A 539
ILE A 578
 None
 1.19A 3a3bA-2w5eA:
3.4		 3a3bA-2w5eA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine leukemia
virus;
Escherichia
coli) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 LEU A 218
THR A 219
ALA A 372
THR A 371
ILE A 374
 None
 1.22A 3a3bA-2xz3A:
undetectable		 3a3bA-2xz3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 VAL A 728
CYH A 777
SER A 776
LEU A 775
ASN A 702
 None
 1.20A 3a3bA-2xzlA:
5.8		 3a3bA-2xzlA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 VAL A  46
LEU A  44
THR A  45
ALA A 329
ASN A 308
 None
 1.18A 3a3bA-2y05A:
undetectable		 3a3bA-2y05A:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a3g LUMAZINE PROTEIN

(Photobacterium
kishitanii) 		PF00677
(Lum_binding) 		12 VAL A  41
CYH A  47
SER A  48
LEU A  49
THR A  50
ASP A  64
GLN A  65
ALA A  66
THR A  69
THR A  70
ASN A 101
ILE A 102
 DLZ  A 191 (-4.4A)
DLZ  A 191 (-3.6A)
DLZ  A 191 (-3.5A)
DLZ  A 191 (-4.2A)
DLZ  A 191 (-4.1A)
DLZ  A 191 (-3.9A)
DLZ  A 191 (-3.5A)
DLZ  A 191 (-3.4A)
DLZ  A 191 (-3.4A)
DLZ  A 191 ( 4.6A)
DLZ  A 191 (-4.5A)
DLZ  A 191 (-4.1A)
 0.38A 3a3bA-3a3gA:
33.7		 3a3bA-3a3gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b95 EUCHROMATIC
HISTONE-LYSINE
N-METHYLTRANSFERASE
1

(Homo sapiens) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A 894
ALA A 882
THR A 850
ASN A 876
ILE A 847
 None
 1.20A 3a3bA-3b95A:
undetectable		 3a3bA-3b95A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 VAL A 458
SER A 556
LEU A 557
THR A 558
ASN A 550
 None
 0.90A 3a3bA-3ctzA:
undetectable		 3a3bA-3ctzA:
15.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ddy LUMAZINE PROTEIN

(Photobacterium
leiognathi) 		PF00677
(Lum_binding) 		7 CYH A  47
ASP A  64
GLN A  65
ALA A  66
THR A  70
ASN A 101
ILE A 102
 RBF  A 187 (-3.3A)
RBF  A 187 (-4.4A)
RBF  A 187 (-3.7A)
RBF  A 187 (-3.1A)
None
RBF  A 187 (-3.7A)
RBF  A 187 (-4.4A)
 0.80A 3a3bA-3ddyA:
29.3		 3a3bA-3ddyA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ddy LUMAZINE PROTEIN

(Photobacterium
leiognathi) 		PF00677
(Lum_binding) 		10 VAL A  41
CYH A  47
SER A  48
THR A  50
ASP A  64
GLN A  65
ALA A  66
THR A  69
THR A  70
ILE A 102
 RBF  A 187 ( 4.5A)
RBF  A 187 (-3.3A)
RBF  A 187 (-4.3A)
RBF  A 187 (-4.4A)
RBF  A 187 (-4.4A)
RBF  A 187 (-3.7A)
RBF  A 187 (-3.1A)
RBF  A 187 (-3.2A)
None
RBF  A 187 (-4.4A)
 0.37A 3a3bA-3ddyA:
29.3		 3a3bA-3ddyA:
55.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ddy LUMAZINE PROTEIN

(Photobacterium
leiognathi) 		PF00677
(Lum_binding) 		8 VAL A  41
SER A  48
THR A  50
ASP A  64
GLN A  65
ALA A  66
THR A  70
ILE A 102
 RBF  A 187 ( 4.5A)
RBF  A 187 (-4.3A)
RBF  A 187 (-4.4A)
RBF  A 187 (-4.4A)
RBF  A 187 (-3.7A)
RBF  A 187 (-3.1A)
None
RBF  A 187 (-4.4A)
 1.48A 3a3bA-3ddyA:
29.3		 3a3bA-3ddyA:
55.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		5 VAL A 528
CYH A 542
SER A 543
LEU A 544
THR A 545
 None
 0.76A 3a3bA-3djaA:
undetectable		 3a3bA-3djaA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 SER A 548
GLN A 542
ALA A 795
THR A 798
ILE A 799
 None
 1.07A 3a3bA-3dy5A:
undetectable		 3a3bA-3dy5A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxt 5-FORMYLTETRAHYDROFO
LATE CYCLO-LIGASE

(Homo sapiens) 		PF01812
(5-FTHF_cyc-lig) 		5 VAL A 192
LEU A 171
THR A 170
THR A  64
ILE A  62
 None
 1.12A 3a3bA-3hxtA:
undetectable		 3a3bA-3hxtA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3in1 UNCHARACTERIZED
SUGAR KINASE YDJH

(Escherichia
coli) 		PF00294
(PfkB) 		5 CYH A   8
THR A  49
ASP A 260
ALA A 140
ILE A   9
 None
 1.15A 3a3bA-3in1A:
undetectable		 3a3bA-3in1A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis) 		PF05943
(VipB) 		5 LEU B 182
ALA B 198
THR B 246
ASN B 171
ILE B 200
 None
 1.16A 3a3bA-3j9oB:
undetectable		 3a3bA-3j9oB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		5 VAL A  59
ALA A 114
THR A 117
THR A 118
ILE A 431
 None
None
None
EDO  A   1 ( 4.5A)
EDO  A   1 (-4.1A)
 0.81A 3a3bA-3k11A:
undetectable		 3a3bA-3k11A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lps TOPOISOMERASE IV
SUBUNIT B

(Xanthomonas
oryzae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 VAL A 348
CYH A 338
LEU A 350
GLN A 413
ALA A 412
 None
 1.08A 3a3bA-3lpsA:
undetectable		 3a3bA-3lpsA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sil SIALIDASE

(Salmonella
enterica) 		PF13859
(BNR_3) 		5 VAL A 116
ASP A 149
THR A  74
THR A  48
ILE A  49
 None
 1.15A 3a3bA-3silA:
undetectable		 3a3bA-3silA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t2x AVIDIN/STREPTAVIDIN

(Shewanella
denitrificans) 		PF01382
(Avidin) 		5 LEU A   7
THR A   8
GLN A 119
ASN A  86
ILE A  85
 None
 1.21A 3a3bA-3t2xA:
undetectable		 3a3bA-3t2xA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		5 CYH A  93
SER A  94
LEU A 126
THR A 127
ALA A  68
 None
 1.07A 3a3bA-3ta6A:
undetectable		 3a3bA-3ta6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		5 THR A 148
GLN A 155
ALA A 156
THR A 161
ILE A 164
 None
 1.13A 3a3bA-3tsyA:
undetectable		 3a3bA-3tsyA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		5 SER A 154
LEU A 157
THR A 222
THR A 144
ASN A 151
 None
 1.09A 3a3bA-3ty7A:
undetectable		 3a3bA-3ty7A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 VAL B 648
THR B 647
ALA B 558
THR B 571
ILE B 579
 None
 1.16A 3a3bA-3v65B:
undetectable		 3a3bA-3v65B:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 SER A 519
LEU A 518
THR A 460
ALA A 359
ASN A 522
 None
 1.21A 3a3bA-4c7vA:
undetectable		 3a3bA-4c7vA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF06187
(DUF993) 		5 VAL A 310
SER A 313
LEU A 312
THR A 309
ALA A 282
 None
 1.17A 3a3bA-4dnhA:
undetectable		 3a3bA-4dnhA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpg LYSINE--TRNA LIGASE

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 SER A 248
ASP A 552
ALA A 555
THR A 559
ILE A 246
 None
 1.11A 3a3bA-4dpgA:
2.5		 3a3bA-4dpgA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0f RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA

(Brucella
abortus) 		PF00677
(Lum_binding) 		5 SER A 149
LEU A 150
THR A 151
THR A 172
ILE A   6
 None
 0.51A 3a3bA-4e0fA:
26.2		 3a3bA-4e0fA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 LEU A 210
ASP A  79
THR A  38
THR A  75
ILE A  73
 None
 1.17A 3a3bA-4elxA:
undetectable		 3a3bA-4elxA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exj UNCHARACTERIZED
PROTEIN

(Lodderomyces
elongisporus) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 VAL A 162
THR A 160
ASP A  78
ASN A  68
ILE A  69
 None
 1.03A 3a3bA-4exjA:
undetectable		 3a3bA-4exjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fq7 MALEATE CIS-TRANS
ISOMERASE

(Pseudomonas
putida) 		no annotation 5 LEU A 206
ALA A 224
THR A 227
THR A 228
ILE A  24
 None
 1.16A 3a3bA-4fq7A:
undetectable		 3a3bA-4fq7A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go5 ASPARTOKINASE

(Mycobacterium
tuberculosis) 		PF01842
(ACT)
PF13840
(ACT_7) 		5 CYH X  65
SER X  66
ALA X  73
ASN X  43
ILE X  44
 None
 1.11A 3a3bA-4go5X:
undetectable		 3a3bA-4go5X:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnh NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Veillonella
parvula) 		PF13460
(NAD_binding_10) 		5 LEU A  64
GLN A  66
ALA A  67
THR A  31
THR A   6
 None
 1.11A 3a3bA-4hnhA:
undetectable		 3a3bA-4hnhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 LEU A 193
THR A 194
ALA A 347
THR A 346
ILE A 349
 None
None
None
TYI  A 342 ( 4.0A)
None
 1.23A 3a3bA-4ikmA:
undetectable		 3a3bA-4ikmA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana) 		PF00491
(Arginase) 		5 SER A 159
LEU A 158
ASP A 137
ALA A 140
ILE A 200
 None
None
MN  A 401 (-2.6A)
None
None
 1.21A 3a3bA-4iu4A:
undetectable		 3a3bA-4iu4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhm MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  40
ASP A 111
ALA A 109
THR A  83
ASN A  79
 None
 1.08A 3a3bA-4jhmA:
undetectable		 3a3bA-4jhmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		5 VAL A 280
CYH A 286
LEU A 289
THR A 290
ILE A 285
 None
 1.18A 3a3bA-4kpnA:
undetectable		 3a3bA-4kpnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq7 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF11175
(DUF2961) 		5 LEU A 360
THR A 359
THR A 295
ASN A 246
ILE A 350
 None
 0.90A 3a3bA-4kq7A:
undetectable		 3a3bA-4kq7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhu 9C2 TCR GAMMA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER G  93
LEU G 121
THR G 120
ASN G  91
ILE G  89
 None
 1.23A 3a3bA-4lhuG:
undetectable		 3a3bA-4lhuG:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj3 HALOALKANE
DEHALOGENASE

(Mycolicibacterium
rhodesiae) 		PF00561
(Abhydrolase_1) 		5 VAL A  49
CYH A 121
LEU A 119
THR A 118
THR A 148
 None
 1.22A 3a3bA-4mj3A:
undetectable		 3a3bA-4mj3A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n75 OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		5 SER A 472
THR A 474
ASP A 447
ASN A 459
ILE A 458
 None
 1.16A 3a3bA-4n75A:
undetectable		 3a3bA-4n75A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuf MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 2 CHIMERIC
CONSTRUCT

(Escherichia
coli;
Mus musculus) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 LEU A 194
THR A 195
ALA A 348
THR A 347
ILE A 350
 None
 1.20A 3a3bA-4nufA:
undetectable		 3a3bA-4nufA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1

(Schizosaccharomyces
pombe) 		no annotation 6 VAL B 470
SER B 505
ALA B 552
THR B 563
ASN B 492
ILE B 549
 None
 1.42A 3a3bA-4o9dB:
undetectable		 3a3bA-4o9dB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqk MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
TRUNCATED
REPLICATION PROTEIN
REPA

(Escherichia
coli;
Staphylococcus
aureus) 		PF13416
(SBP_bac_8) 		5 LEU A 193
THR A 194
ALA A 347
THR A 346
ILE A 349
 None
 1.20A 3a3bA-4pqkA:
undetectable		 3a3bA-4pqkA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 VAL A 638
SER A 632
LEU A 631
THR A 630
ASP A 498
 None
 1.23A 3a3bA-4qi7A:
undetectable		 3a3bA-4qi7A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnm IMPORTIN SUBUNIT
ALPHA

(Arabidopsis
thaliana) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 CYH A 232
SER A 229
LEU A 228
THR A 225
THR A 243
 None
 1.18A 3a3bA-4tnmA:
undetectable		 3a3bA-4tnmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 LEU A 767
THR A 803
GLN A 791
ALA A 779
THR A 819
 None
 1.13A 3a3bA-4u48A:
undetectable		 3a3bA-4u48A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 CYH A 676
LEU A 710
ALA A 689
ASN A 707
ILE A 677
 None
 1.03A 3a3bA-4u90A:
undetectable		 3a3bA-4u90A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 LEU A1031
THR A1032
ALA A1093
THR A1096
ILE A1097
 None
 1.06A 3a3bA-4yswA:
undetectable		 3a3bA-4yswA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		5 VAL A  54
THR A 135
THR A  17
ASN A 115
ILE A  34
 None
 1.07A 3a3bA-5cfaA:
2.3		 3a3bA-5cfaA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cpg (R)-SPECIFIC
ENOYL-COA HYDRATASE

(Pseudomonas
aeruginosa) 		PF01575
(MaoC_dehydratas) 		5 VAL A  14
LEU A  12
ALA A 138
THR A  81
ILE A 136
 None
None
None
GOL  A 201 ( 4.7A)
None
 1.21A 3a3bA-5cpgA:
undetectable		 3a3bA-5cpgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 LEU B 300
THR B 301
ALA B 454
THR B 453
ILE B 456
 None
 1.20A 3a3bA-5eduB:
undetectable		 3a3bA-5eduB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Staphylococcus
aureus) 		no annotation 5 VAL B  42
LEU B 126
THR B 125
THR B  35
ASN B  38
 None
 0.98A 3a3bA-5ey0B:
undetectable		 3a3bA-5ey0B:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 VAL A  65
ASP A  47
ALA A  45
THR A 302
THR A 301
 None
 1.22A 3a3bA-5fyaA:
undetectable		 3a3bA-5fyaA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 5 LEU A 354
THR A 355
THR A 381
THR A 384
ILE A 380
 None
 1.15A 3a3bA-5iwzA:
undetectable		 3a3bA-5iwzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 CYH A 385
ALA A 340
THR A 417
THR A 416
ILE A 338
 None
 1.21A 3a3bA-5ks8A:
undetectable		 3a3bA-5ks8A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 LEU C 188
THR C 185
ASP C 175
THR C 142
ILE C 171
 None
 1.22A 3a3bA-5ks8C:
undetectable		 3a3bA-5ks8C:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL

(Bos taurus) 		PF01058
(Oxidored_q6) 		5 VAL B 132
CYH B 136
LEU B  92
THR B  93
ASN B 121
 None
 1.09A 3a3bA-5lc5B:
undetectable		 3a3bA-5lc5B:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfd ALLANTOIN RACEMASE

(Pseudomonas
fluorescens) 		no annotation 5 SER A 111
GLN A 163
ALA A 164
THR A 194
ILE A 168
 None
 1.18A 3a3bA-5lfdA:
undetectable		 3a3bA-5lfdA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 SER A 623
LEU A 622
ALA A 659
THR A 672
ILE A 656
 None
 1.05A 3a3bA-5m2nA:
undetectable		 3a3bA-5m2nA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 5 CYH A 521
LEU A 507
GLN A 503
THR A 297
ILE A 501
 None
 1.20A 3a3bA-5odoA:
undetectable		 3a3bA-5odoA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjj TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Alicyclobacillus
acidocaldarius) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		5 VAL A 218
CYH A 221
SER A 220
ALA A 236
THR A  98
 None
 1.05A 3a3bA-5tjjA:
undetectable		 3a3bA-5tjjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		5 LEU A  53
THR A  52
ALA A  93
THR A 163
ASN A  23
 None
 1.22A 3a3bA-5ujsA:
undetectable		 3a3bA-5ujsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6y MALTOSE-BINDING
PERIPLASMIC
PROTEIN,RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 1,CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 5 LEU A 194
THR A 195
ALA A 348
THR A 347
ILE A 350
 None
 1.22A 3a3bA-5v6yA:
undetectable		 3a3bA-5v6yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w23 5C4 FAB HEAVY CHAIN

(Mus musculus) 		no annotation 5 THR H  73
ASP H  52
THR H  95
THR H  94
ILE H  96
 None
 1.20A 3a3bA-5w23H:
undetectable		 3a3bA-5w23H:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER

(Pseudomonas
aeruginosa) 		no annotation 5 LEU B   4
THR B   3
GLN B   7
ALA B   6
ASN B  66
 None
 1.01A 3a3bA-5x5yB:
undetectable		 3a3bA-5x5yB:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcb PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 5 LEU A 329
THR A 330
ALA A 146
THR A 177
ASN A 318
 None
 1.20A 3a3bA-5xcbA:
undetectable		 3a3bA-5xcbA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcc PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 5 LEU A 329
THR A 330
ALA A 146
THR A 177
ASN A 318
 None
 1.18A 3a3bA-5xccA:
undetectable		 3a3bA-5xccA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 6 LEU A 435
THR A 436
ASP A 467
ALA A 466
THR A 498
ILE A 497
 None
 1.45A 3a3bA-6b3bA:
undetectable		 3a3bA-6b3bA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6by9 HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		no annotation 5 LEU A 925
ALA A 913
THR A 881
ASN A 907
ILE A 878
 None
 1.16A 3a3bA-6by9A:
undetectable		 3a3bA-6by9A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f PROTEASOME-INTERACTI
NG PROTEIN CIC1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU K 190
THR K 188
ASP K 183
ALA K 182
ILE K 180
 None
C  6   5 ( 2.9A)
None
None
None
 1.21A 3a3bA-6c0fK:
undetectable		 3a3bA-6c0fK:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G

(Pyrococcus
furiosus) 		no annotation 5 VAL A 136
LEU A 123
ALA C  91
THR C  39
ASN A 114
 None
 1.18A 3a3bA-6cfwA:
undetectable		 3a3bA-6cfwA:
19.57