SIMILAR PATTERNS OF AMINO ACIDS FOR 3A27_A_SAMA250_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASN A 185
PHE A  42
GLY A  39
TYR A 170
PHE A 350
 None
 1.46A 3a27A-1bqgA:
0.8		 3a27A-1bqgA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 ASN A 337
GLY A 215
TYR A 338
TYR A 560
PHE A 559
 None
 1.40A 3a27A-1ex0A:
undetectable		 3a27A-1ex0A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		5 SER A 762
ARG A 120
GLY A 169
ASN A 171
TYR A 163
 None
 1.46A 3a27A-1k32A:
0.0		 3a27A-1k32A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w07 ACYL-COA OXIDASE

(Arabidopsis
thaliana) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 SER A  51
ASN A  52
ARG A  55
GLY A 232
ASP A 238
 None
 1.24A 3a27A-1w07A:
undetectable		 3a27A-1w07A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		5 SER A 309
ASN A 225
ASP A 242
ARG A 245
TYR A 334
 None
NDG  A1042 (-2.4A)
None
None
None
 1.36A 3a27A-1wnoA:
undetectable		 3a27A-1wnoA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF01904
(DUF72) 		5 ASN A 218
PHE A 193
GLY A 195
TYR A 215
PHE A 191
 None
 1.22A 3a27A-1ztvA:
undetectable		 3a27A-1ztvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		5 SER A  63
GLY A 390
ASP A 373
ARG A 338
PHE A 339
 None
 1.46A 3a27A-2horA:
undetectable		 3a27A-2horA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 SER A 441
TYR A 446
ASN A 509
ARG A 113
PHE A 117
 None
 1.42A 3a27A-2inyA:
undetectable		 3a27A-2inyA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		5 SER A 213
ARG A 209
GLY A 256
ASN A 258
ASP A 227
 None
 1.23A 3a27A-2ojhA:
undetectable		 3a27A-2ojhA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C

(Listeria
monocytogenes) 		PF00388
(PI-PLC-X) 		5 ASN A 230
GLY A 273
ASN A 235
ARG A 124
PHE A 195
 None
 1.13A 3a27A-2plcA:
undetectable		 3a27A-2plcA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp1 PERIPLASMIC
IRON-BINDING PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13343
(SBP_bac_6) 		5 PHE A 281
GLY A  55
ASP A  47
ARG A  42
PHE A  84
 None
 1.06A 3a27A-2vp1A:
undetectable		 3a27A-2vp1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd6 AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF06696
(Strep_SA_rep)
PF08363
(GbpC) 		5 SER A 688
GLY A 724
TYR A 673
ASN A 645
PHE A 629
 None
 1.33A 3a27A-2wd6A:
undetectable		 3a27A-2wd6A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw2 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Aquifex
aeolicus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		5 SER A 232
PHE A 267
GLY A 289
ASN A 285
PHE A  90
 None
 1.45A 3a27A-2yw2A:
4.1		 3a27A-2yw2A:
23.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a27 UNCHARACTERIZED
PROTEIN MJ1557

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		12 SER A  80
ASN A  83
ARG A  87
PHE A 104
GLY A 106
TYR A 109
LYS A 128
ASN A 129
ASP A 154
ARG A 156
TYR A 171
PHE A 178
 SAM  A 250 (-4.3A)
SAM  A 250 (-3.8A)
SAM  A 250 (-4.7A)
SAM  A 250 (-4.7A)
SAM  A 250 (-3.6A)
SAM  A 250 (-3.6A)
SAM  A 250 (-3.5A)
None
SAM  A 250 (-3.2A)
SAM  A 250 ( 4.7A)
SAM  A 250 (-4.1A)
SAM  A 250 (-4.6A)
 0.00A 3a27A-3a27A:
40.6		 3a27A-3a27A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
kodakarensis) 		no annotation 5 ARG A 178
GLY A 172
LYS A 136
ARG A 102
TYR A 156
 None
 1.28A 3a27A-3anwA:
undetectable		 3a27A-3anwA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		5 PHE A 203
GLY A 205
ASN A 225
ASP A 251
PHE A 273
 ADN  A 401 (-4.9A)
ADN  A 401 ( 4.0A)
ADN  A 401 (-4.9A)
ADN  A 401 (-3.8A)
ADN  A 401 (-4.6A)
 0.54A 3a27A-3ay0A:
26.2		 3a27A-3ay0A:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		5 PHE A 203
GLY A 205
ASP A 251
ARG A 253
PHE A 273
 ADN  A 401 (-4.9A)
ADN  A 401 ( 4.0A)
ADN  A 401 (-3.8A)
None
ADN  A 401 (-4.6A)
 0.90A 3a27A-3ay0A:
26.2		 3a27A-3ay0A:
31.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		5 PHE A  75
GLY A 105
ASN A 113
TYR A 132
PHE A 313
 None
 1.45A 3a27A-3bmaA:
1.1		 3a27A-3bmaA:
18.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		6 ARG A 116
PHE A 133
GLY A 135
ARG A 185
TYR A 200
PHE A 207
 None
 0.76A 3a27A-3k6rA:
30.1		 3a27A-3k6rA:
40.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		7 SER A 109
ARG A 116
PHE A 133
GLY A 135
ASP A 183
TYR A 200
PHE A 207
 None
 0.55A 3a27A-3k6rA:
30.1		 3a27A-3k6rA:
40.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ASN A 103
GLY A  69
TYR A  68
ASP A 316
TYR A  92
 None
 1.48A 3a27A-3mcxA:
undetectable		 3a27A-3mcxA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8h THYMIDYLATE SYNTHASE

(Burkholderia
thailandensis) 		PF00303
(Thymidylat_synt) 		5 SER A  68
ARG A  73
GLY A  76
ASP A 305
ARG A 283
 None
None
EDO  A 325 ( 4.9A)
None
None
 1.47A 3a27A-3v8hA:
undetectable		 3a27A-3v8hA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2w CRISPR SYSTEM CMR
SUBUNIT CMR3

(Pyrococcus
furiosus) 		PF09700
(Cas_Cmr3) 		5 ARG B  77
TYR B 175
ASP B  10
ARG B 146
PHE B 168
 None
 1.39A 3a27A-3w2wB:
undetectable		 3a27A-3w2wB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe NONSENSE-MEDIATED
MRNA DECAY PROTEIN

(Caenorhabditis
elegans) 		no annotation 5 SER A 353
ASN A 357
GLY A 131
ASN A 109
ASP A 114
 None
 1.45A 3a27A-3zheA:
undetectable		 3a27A-3zheA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 SER A  13
ASN A 318
GLY A 518
TYR A 406
PHE A 530
 None
 1.42A 3a27A-4cgtA:
undetectable		 3a27A-4cgtA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		5 GLY A 517
ASN A 436
ASP A 450
ARG A 455
TYR A 497
 None
4NS  A 601 (-3.3A)
None
None
None
 1.42A 3a27A-4p05A:
undetectable		 3a27A-4p05A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 SER A 833
ASN A 831
GLY A 755
TYR A 739
ASN A 761
 None
 1.32A 3a27A-4qnlA:
undetectable		 3a27A-4qnlA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 5 SER A 833
ASN A 831
GLY A 755
TYR A 739
ASP A 808
 None
 1.06A 3a27A-4qnlA:
undetectable		 3a27A-4qnlA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brq GLYCOSIDE HYDROLASE
FAMILY 13

(Bacillus
licheniformis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 SER A 245
ASN A 240
GLY A 199
LYS A  97
ASP A  49
 None
 1.28A 3a27A-5brqA:
undetectable		 3a27A-5brqA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7z LACTOYLGLUTATHIONE
LYASE

(Zea mays) 		PF00903
(Glyoxalase) 		5 PHE A  94
GLY A  91
ASN A 222
TYR A 224
PHE A  97
 None
 1.41A 3a27A-5d7zA:
undetectable		 3a27A-5d7zA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes) 		no annotation 5 SER B 245
ASN B 240
GLY B 193
LYS B  95
ASP B  47
 None
 1.24A 3a27A-5do8B:
undetectable		 3a27A-5do8B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 5 SER A 567
GLY A 358
ASN A 401
ASP A 458
TYR A 429
 None
 1.26A 3a27A-5gqfA:
undetectable		 3a27A-5gqfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqf LACTO-N-BIOSIDASE

(Bifidobacterium
longum) 		no annotation 5 SER A 567
GLY A 358
TYR A 334
ASN A 401
ASP A 458
 None
 1.19A 3a27A-5gqfA:
undetectable		 3a27A-5gqfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 5 SER A 318
GLY A 339
TYR A 316
ASN A 341
TYR A 292
 None
 1.37A 3a27A-5h4eA:
undetectable		 3a27A-5h4eA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Bacillus cereus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 SER A  50
PHE A  82
GLY A  77
TYR A  75
PHE A 116
 None
 1.50A 3a27A-5je8A:
6.6		 3a27A-5je8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL

(Bos taurus) 		PF00346
(Complex1_49kDa) 		5 SER D 119
ARG D 138
GLY D 142
ARG D 174
PHE D 178
 None
 1.28A 3a27A-5lc5D:
undetectable		 3a27A-5lc5D:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 SER A 446
ASN A 368
ARG A 432
PHE A 337
GLY A 373
 None
 1.49A 3a27A-5ngkA:
undetectable		 3a27A-5ngkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		5 SER A 186
ASN A 454
PHE A 536
GLY A 538
ASP A 602
 None
 1.47A 3a27A-5svcA:
undetectable		 3a27A-5svcA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		5 SER A 398
PHE A 536
GLY A 538
TYR A 399
ASP A 602
 None
 1.49A 3a27A-5svcA:
undetectable		 3a27A-5svcA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt3 TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A

(Pyrococcus
abyssi) 		no annotation 5 ARG A 174
PHE A 191
GLY A 193
ASN A 215
ASP A 243
 None
MTA  A 401 (-4.4A)
MTA  A 401 (-3.6A)
None
MTA  A 401 (-3.3A)
 0.81A 3a27A-5wt3A:
23.7		 3a27A-5wt3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 5 ASN A1136
GLY A 955
TYR A1096
ASN A 861
PHE A 824
 None
 1.48A 3a27A-5xwyA:
undetectable		 3a27A-5xwyA:
13.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B

(Pyrococcus
abyssi) 		PF02475
(Met_10) 		5 SER A 166
PHE A 190
ASP A 238
ARG A 240
PHE A 260
 None
 0.74A 3a27A-5yacA:
27.0		 3a27A-5yacA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B

(Pyrococcus
abyssi) 		PF02475
(Met_10) 		6 SER A 166
PHE A 190
GLY A 192
ASN A 213
ASP A 238
PHE A 260
 None
 0.72A 3a27A-5yacA:
27.0		 3a27A-5yacA:
35.67