SIMILAR PATTERNS OF AMINO ACIDS FOR 3A25_A_SAMA279_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		3 MET A 111
GLU A 193
ASP A 437
 None
 0.99A 3a25A-1aqlA:
undetectable		 3a25A-1aqlA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		3 MET A 237
GLU A  54
ASP A  56
 None
 1.12A 3a25A-1bjnA:
2.0		 3a25A-1bjnA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		3 MET A 184
GLU A 146
ASP A 131
 None
 1.05A 3a25A-1g55A:
8.9		 3a25A-1g55A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7r TRANSLATION
INITIATION FACTOR
IF2/EIF5B

(Methanothermobacter
thermautotrophicus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		3 MET A 457
GLU A 570
ASP A 568
 None
 1.00A 3a25A-1g7rA:
undetectable		 3a25A-1g7rA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1if1 PROTEIN (INTERFERON
REGULATORY FACTOR 1)

(Mus musculus) 		PF00605
(IRF) 		3 MET A 111
GLU A  92
ASP A  96
 None
 1.12A 3a25A-1if1A:
undetectable		 3a25A-1if1A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iom CITRATE SYNTHASE

(Thermus
thermophilus) 		PF00285
(Citrate_synt) 		3 MET A  92
GLU A 224
ASP A 312
 None
None
GOL  A 400 (-2.9A)
 1.08A 3a25A-1iomA:
undetectable		 3a25A-1iomA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 MET A 306
GLU A 313
ASP A 352
 None
 0.67A 3a25A-1kblA:
undetectable		 3a25A-1kblA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		3 MET B 100
GLU B  65
ASP B 140
 None
 1.09A 3a25A-1kwcB:
undetectable		 3a25A-1kwcB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 MET B 450
GLU B 443
ASP B 483
 None
 1.10A 3a25A-1ldkB:
undetectable		 3a25A-1ldkB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1noz DNA POLYMERASE

(Escherichia
virus T4) 		PF03104
(DNA_pol_B_exo1) 		3 MET A 356
GLU A 216
ASP A 219
 None
 1.08A 3a25A-1nozA:
undetectable		 3a25A-1nozA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9w GENERAL SECRETION
PATHWAY PROTEIN E

(Vibrio cholerae) 		PF00437
(T2SSE) 		3 MET A 355
GLU A 292
ASP A 298
 None
 1.10A 3a25A-1p9wA:
3.0		 3a25A-1p9wA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		3 MET A 325
GLU A 126
ASP A 150
 None
 1.11A 3a25A-1r0lA:
5.0		 3a25A-1r0lA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw9 CHONDROITIN AC LYASE

(Paenarthrobacter
aurescens) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 MET A 386
GLU A 372
ASP A 342
 None
 0.88A 3a25A-1rw9A:
undetectable		 3a25A-1rw9A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		3 MET A 502
GLU A 489
ASP A 145
 None
 1.11A 3a25A-1sy7A:
undetectable		 3a25A-1sy7A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 MET A  43
GLU A 662
ASP A 468
 None
None
2MD  A 799 (-3.1A)
 1.04A 3a25A-1tmoA:
undetectable		 3a25A-1tmoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		3 MET A 258
GLU A 214
ASP A 229
 None
 0.97A 3a25A-1vp4A:
4.0		 3a25A-1vp4A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		3 MET A 996
GLU A 977
ASP A 803
 None
 0.67A 3a25A-1xf1A:
undetectable		 3a25A-1xf1A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Pyrococcus
abyssi;
Pyrococcus
abyssi) 		PF00710
(Asparaginase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		3 MET A  36
GLU A  40
ASP C 437
 None
 1.10A 3a25A-1zq1A:
undetectable		 3a25A-1zq1A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 MET A 938
GLU A 943
ASP A 986
 None
 1.04A 3a25A-2b5mA:
undetectable		 3a25A-2b5mA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl0 MYOSIN REGULATORY
LIGHT CHAIN

(Physarum
polycephalum) 		PF13833
(EF-hand_8) 		3 MET C 152
GLU C  19
ASP C  14
 None
 0.77A 3a25A-2bl0C:
undetectable		 3a25A-2bl0C:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)

(Homo sapiens) 		PF03051
(Peptidase_C1_2) 		3 MET A 149
GLU A 421
ASP A 273
 None
 0.81A 3a25A-2cb5A:
undetectable		 3a25A-2cb5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cpd APOBEC-1 STIMULATING
PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		3 MET A 283
GLU A 277
ASP A 225
 None
 1.12A 3a25A-2cpdA:
undetectable		 3a25A-2cpdA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drq XYLANASE Y

(Bacillus
halodurans) 		PF01270
(Glyco_hydro_8) 		3 MET A 101
GLU A 130
ASP A 128
 None
 1.10A 3a25A-2drqA:
undetectable		 3a25A-2drqA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		3 MET A 258
GLU A 316
ASP A 329
 None
 1.01A 3a25A-2hrzA:
3.4		 3a25A-2hrzA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ia2 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		3 MET A 133
GLU A 109
ASP A 240
 None
 0.94A 3a25A-2ia2A:
undetectable		 3a25A-2ia2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib0 CONSERVED
HYPOTHETICAL ALANINE
RICH PROTEIN

(Mycobacterium
tuberculosis) 		PF14530
(DUF4439) 		3 MET A 106
GLU A  33
ASP A  67
 None
 1.03A 3a25A-2ib0A:
undetectable		 3a25A-2ib0A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib0 CONSERVED
HYPOTHETICAL ALANINE
RICH PROTEIN

(Mycobacterium
tuberculosis) 		PF14530
(DUF4439) 		3 MET A 140
GLU A  33
ASP A  67
 None
 0.89A 3a25A-2ib0A:
undetectable		 3a25A-2ib0A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		3 MET A 157
GLU A 407
ASP A 198
 PRI  A1566 ( 3.6A)
MN  A1567 (-2.5A)
None
 0.92A 3a25A-2j3mA:
undetectable		 3a25A-2j3mA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		3 MET A 279
GLU A  89
ASP A  66
 None
 1.12A 3a25A-2owzA:
undetectable		 3a25A-2owzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1i RIBONUCLEOTIDE
REDUCTASE, SMALL
CHAIN

(Plasmodium
yoelii) 		PF00268
(Ribonuc_red_sm) 		3 MET A 275
GLU A  84
ASP A  76
 None
 1.06A 3a25A-2p1iA:
undetectable		 3a25A-2p1iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		3 MET A 874
GLU A 856
ASP A 722
 IBM  A   3 ( 3.8A)
None
MG  A   2 ( 2.6A)
 1.04A 3a25A-2r8qA:
undetectable		 3a25A-2r8qA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		3 MET A  54
GLU A 337
ASP A 335
 None
 1.12A 3a25A-2rjbA:
undetectable		 3a25A-2rjbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkj TYROSYL-TRNA
SYNTHETASE

(Neurospora
crassa) 		PF00579
(tRNA-synt_1b) 		3 MET A 367
GLU A 358
ASP A 354
 None
 0.92A 3a25A-2rkjA:
2.6		 3a25A-2rkjA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 MET A 973
GLU A1094
ASP A1090
 None
 1.06A 3a25A-2vsqA:
undetectable		 3a25A-2vsqA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		3 MET A  23
GLU A   7
ASP A  41
 None
 0.79A 3a25A-2xsbA:
undetectable		 3a25A-2xsbA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7b MLR6791 PROTEIN

(Mesorhizobium
japonicum) 		PF00596
(Aldolase_II) 		3 MET A   1
GLU A   8
ASP A 218
 None
 1.06A 3a25A-2z7bA:
undetectable		 3a25A-2z7bA:
26.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3a27 UNCHARACTERIZED
PROTEIN MJ1557

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		3 MET A  78
GLU A 127
ASP A 154
 SAM  A 250 (-4.2A)
SAM  A 250 (-3.0A)
SAM  A 250 (-3.2A)
 0.85A 3a25A-3a27A:
31.1		 3a25A-3a27A:
44.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abg BILIRUBIN OXIDASE

(Albifimbria
verrucaria) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 MET A  10
GLU A 292
ASP A 245
 None
 1.03A 3a25A-3abgA:
undetectable		 3a25A-3abgA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		3 MET B 148
GLU B 126
ASP B 281
 None
 0.80A 3a25A-3al0B:
undetectable		 3a25A-3al0B:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		3 MET A 256
GLU A  36
ASP A 207
 None
 1.09A 3a25A-3brqA:
undetectable		 3a25A-3brqA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 MET A 528
GLU A 543
ASP A 801
 None
None
ZN  A 101 ( 2.5A)
 1.10A 3a25A-3c10A:
3.4		 3a25A-3c10A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION

(Ruegeria
pomeroyi) 		no annotation 3 MET A  66
GLU A  35
ASP A 152
 None
 1.10A 3a25A-3cvoA:
10.1		 3a25A-3cvoA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gw4 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		PF13424
(TPR_12) 		3 MET A  75
GLU A  93
ASP A 103
 None
 0.75A 3a25A-3gw4A:
undetectable		 3a25A-3gw4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		3 MET A 163
GLU A 213
ASP A 240
 SAH  A 350 ( 3.7A)
SAH  A 350 (-2.9A)
SAH  A 350 (-3.4A)
 0.99A 3a25A-3gxoA:
15.0		 3a25A-3gxoA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 MET A 342
GLU A 348
ASP A 623
 None
 0.77A 3a25A-3j04A:
undetectable		 3a25A-3j04A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 MET A 285
GLU A 251
ASP A 256
 None
 0.92A 3a25A-3k6kA:
2.1		 3a25A-3k6kA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		3 MET B 921
GLU B1020
ASP B 961
 None
 0.88A 3a25A-3k70B:
undetectable		 3a25A-3k70B:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		3 MET A  94
GLU A 246
ASP A 225
 None
 1.08A 3a25A-3m9uA:
undetectable		 3a25A-3m9uA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obe SUGAR PHOSPHATE
ISOMERASE/EPIMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		3 MET A 249
GLU A 304
ASP A 306
 None
 0.94A 3a25A-3obeA:
undetectable		 3a25A-3obeA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 MET A 410
GLU A  55
ASP A 420
 None
None
ACR  A 664 (-2.8A)
 0.95A 3a25A-3pocA:
undetectable		 3a25A-3pocA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2i DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 MET A 238
GLU A 221
ASP A 182
 None
 1.03A 3a25A-3q2iA:
5.3		 3a25A-3q2iA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 MET A 380
GLU A 360
ASP A 241
 None
 1.12A 3a25A-3qlvA:
undetectable		 3a25A-3qlvA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
marinum) 		PF03641
(Lysine_decarbox) 		3 MET A 133
GLU A 103
ASP A 120
 None
None
AMP  A 188 (-3.5A)
 0.95A 3a25A-3sbxA:
3.6		 3a25A-3sbxA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Coprinopsis
cinerea) 		no annotation 3 MET A  94
GLU A  98
ASP A 216
 GOL  A 503 ( 3.9A)
None
None
 1.09A 3a25A-3w9aA:
undetectable		 3a25A-3w9aA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlc ER-DERIVED VESICLES
PROTEIN ERV41

(Saccharomyces
cerevisiae) 		PF07970
(COPIIcoated_ERV)
PF13850
(ERGIC_N) 		3 MET A 276
GLU A 176
ASP A  86
 None
 1.08A 3a25A-3zlcA:
undetectable		 3a25A-3zlcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k CULLIN-4A

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 MET A 498
GLU A 472
ASP A 414
 None
 0.93A 3a25A-4a0kA:
undetectable		 3a25A-4a0kA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 MET E 652
GLU E 626
ASP E 568
 None
 1.06A 3a25A-4a0lE:
undetectable		 3a25A-4a0lE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4k ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF13234
(rRNA_proc-arch) 		3 MET A 875
GLU A 981
ASP A 909
 None
 0.76A 3a25A-4a4kA:
undetectable		 3a25A-4a4kA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster) 		no annotation 3 MET A 785
GLU A 778
ASP A 748
 None
 0.96A 3a25A-4bwpA:
undetectable		 3a25A-4bwpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 16 HOMOLOG

(Homo sapiens;
Homo sapiens) 		PF00995
(Sec1)
PF04840
(Vps16_C) 		3 MET A 592
GLU A 439
ASP C 698
 None
 1.11A 3a25A-4bx9A:
3.7		 3a25A-4bx9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cby HISTONE DEACETYLASE
4

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 MET A 662
GLU A 677
ASP A 934
 None
None
ZN  A2034 ( 2.4A)
 1.07A 3a25A-4cbyA:
3.4		 3a25A-4cbyA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euf PUTATIVE REDUCTASE
CA_C0462

(Clostridium
acetobutylicum) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		3 MET A 307
GLU A  23
ASP A 378
 None
 0.86A 3a25A-4eufA:
5.6		 3a25A-4eufA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 MET B 641
GLU B 602
ASP B 594
 None
 1.06A 3a25A-4f92B:
2.9		 3a25A-4f92B:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzy EXODEOXYRIBONUCLEASE
10

(Escherichia
coli) 		PF00929
(RNase_T) 		3 MET A  57
GLU A  18
ASP A 139
 None
None
NA  A 201 (-3.1A)
 1.05A 3a25A-4fzyA:
undetectable		 3a25A-4fzyA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 MET B 637
GLU B 547
ASP B 556
 CME  B 592 ( 4.9A)
None
None
 1.02A 3a25A-4g7eB:
undetectable		 3a25A-4g7eB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA
NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas sp.
C18;
Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		3 MET B 190
GLU B  89
ASP A 264
 EDO  B 201 (-4.1A)
None
None
 1.01A 3a25A-4hjlB:
undetectable		 3a25A-4hjlB:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina) 		PF00652
(Ricin_B_lectin) 		3 MET C 148
GLU C 151
ASP C 154
 None
 1.07A 3a25A-4hr6C:
undetectable		 3a25A-4hr6C:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5n SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT BETA -
CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG CHIMERIC
CONSTRUCT

(Homo sapiens) 		PF13499
(EF-hand_7) 		3 MET B 351
GLU B 384
ASP B 386
 None
 1.07A 3a25A-4i5nB:
undetectable		 3a25A-4i5nB:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8o TOXIN RNLA

(Escherichia
coli) 		PF15935
(RnlA_toxin) 		3 MET A 103
GLU A  99
ASP A 246
 None
 0.97A 3a25A-4i8oA:
undetectable		 3a25A-4i8oA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kss TYPE II SECRETION
SYSTEM PROTEIN E,
HEMOLYSIN-COREGULATE
D PROTEIN

(Pseudomonas
aeruginosa;
Vibrio cholerae) 		PF00437
(T2SSE)
PF05638
(T6SS_HCP) 		3 MET A 355
GLU A 292
ASP A 298
 None
 1.03A 3a25A-4kssA:
undetectable		 3a25A-4kssA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le4 BETA-GLUCANASE

(Podospora
anserina) 		no annotation 3 MET A  95
GLU A  99
ASP A 222
 None
 1.09A 3a25A-4le4A:
undetectable		 3a25A-4le4A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mch URIDINE
PHOSPHORYLASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		3 MET A 180
GLU A 163
ASP A 161
 DMS  A 513 ( 4.3A)
None
None
 1.10A 3a25A-4mchA:
undetectable		 3a25A-4mchA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY PROTEIN
LPTD

(Salmonella
enterica) 		PF04453
(OstA_C) 		3 MET A 271
GLU A 242
ASP A 751
 None
 1.10A 3a25A-4n4rA:
undetectable		 3a25A-4n4rA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7r GLUTAMYL-TRNA
REDUCTASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		3 MET A 420
GLU A 196
ASP A 189
 None
 0.86A 3a25A-4n7rA:
6.5		 3a25A-4n7rA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n91 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Anaerococcus
prevotii) 		PF03480
(DctP) 		3 MET A 239
GLU A 217
ASP A 282
 None
 1.05A 3a25A-4n91A:
undetectable		 3a25A-4n91A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p58 CATECHOL
O-METHYLTRANSFERASE

(Mus musculus) 		PF01596
(Methyltransf_3) 		3 MET A 145
GLU A 107
ASP A 212
 None
 0.91A 3a25A-4p58A:
13.5		 3a25A-4p58A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E

(Vibrio
vulnificus) 		PF00437
(T2SSE) 		3 MET A 351
GLU A 288
ASP A 294
 None
 1.10A 3a25A-4phtA:
undetectable		 3a25A-4phtA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyb SEC14-LIKE PROTEIN 3

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		3 MET A  60
GLU A 129
ASP A 136
 None
 1.03A 3a25A-4uybA:
undetectable		 3a25A-4uybA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4za3 RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00652
(Ricin_B_lectin) 		3 MET B 147
GLU B 150
ASP B 153
 None
 1.10A 3a25A-4za3B:
undetectable		 3a25A-4za3B:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA

(Mycolicibacterium
thermoresistibile) 		no annotation 3 MET C 192
GLU C 166
ASP C 164
 None
 1.03A 3a25A-5cw2C:
undetectable		 3a25A-5cw2C:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		3 MET A 330
GLU A 111
ASP A  14
 MAL  A 601 ( 4.3A)
MAL  A 601 (-3.0A)
SO4  A 602 ( 4.7A)
 0.97A 3a25A-5dfmA:
undetectable		 3a25A-5dfmA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 3 MET B 489
GLU B 502
ASP B 742
 None
None
ZN  B2502 ( 2.7A)
 0.97A 3a25A-5eduB:
3.5		 3a25A-5eduB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio) 		no annotation 3 MET B 452
GLU B 465
ASP B 705
 None
None
ZN  B 801 (-2.6A)
 1.00A 3a25A-5efnB:
undetectable		 3a25A-5efnB:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		3 MET A 327
GLU A 276
ASP A 345
 None
 0.92A 3a25A-5f7uA:
undetectable		 3a25A-5f7uA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0h HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		3 MET A 452
GLU A 465
ASP A 705
 None
None
ZN  A1804 ( 2.5A)
 1.00A 3a25A-5g0hA:
2.3		 3a25A-5g0hA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 MET A 529
GLU A 322
ASP A 607
 None
 1.02A 3a25A-5gxuA:
undetectable		 3a25A-5gxuA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 3 MET A 862
GLU A 844
ASP A 710
 LLN  A1003 (-3.5A)
None
MG  A1002 ( 2.6A)
 1.03A 3a25A-5h2rA:
undetectable		 3a25A-5h2rA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		3 MET A 389
GLU A 342
ASP A 325
 None
 1.12A 3a25A-5h2vA:
undetectable		 3a25A-5h2vA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		3 MET A 385
GLU A 166
ASP A  69
 MAL  A 803 ( 3.5A)
MAL  A 803 (-2.7A)
None
 0.98A 3a25A-5hzwA:
undetectable		 3a25A-5hzwA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0p BETA-LACTAMASE
DOMAIN PROTEIN

(Burkholderia
ambifaria) 		PF00753
(Lactamase_B) 		3 MET A 127
GLU A 208
ASP A 188
 None
 1.11A 3a25A-5i0pA:
undetectable		 3a25A-5i0pA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 MET B 662
GLU B 810
ASP B1043
 None
 1.10A 3a25A-5ip9B:
undetectable		 3a25A-5ip9B:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens;
Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3)
PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		3 MET A 702
GLU B1844
ASP B1884
 None
 0.91A 3a25A-5k8dA:
undetectable		 3a25A-5k8dA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4w CULLIN-2

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 MET A 480
GLU A 454
ASP A 396
 None
 0.74A 3a25A-5n4wA:
undetectable		 3a25A-5n4wA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlm INDOXYL
UDP-GLUCOSYLTRANSFER
ASE

(Persicaria
tinctoria) 		no annotation 3 MET A  24
GLU A 378
ASP A 357
 None
 1.06A 3a25A-5nlmA:
4.0		 3a25A-5nlmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szp PROTOCADHERIN GAMMA
B7

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		3 MET A 169
GLU A 173
ASP A 238
 None
CA  A 505 ( 2.4A)
CA  A 506 (-2.2A)
 1.09A 3a25A-5szpA:
undetectable		 3a25A-5szpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td7 ZGC:55652

(Danio rerio) 		PF00850
(Hist_deacetyl) 		3 MET A  13
GLU A  28
ASP A 267
 None
None
ZN  A 701 ( 2.6A)
 0.97A 3a25A-5td7A:
3.4		 3a25A-5td7A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		3 MET A 357
GLU A 869
ASP A 899
 None
 1.02A 3a25A-5um6A:
4.2		 3a25A-5um6A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5un1 IONOTROPIC GLUTAMATE
RECEPTOR SUBUNIT
NR2B
N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-3A

(Xenopus laevis;
Xenopus laevis) 		no annotation
no annotation 		3 MET B 501
GLU G 473
ASP G 509
 None
 1.05A 3a25A-5un1B:
undetectable		 3a25A-5un1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao1 BETA-LACTAMASE
DOMAIN PROTEIN

(Paraburkholderia
phymatum) 		PF00753
(Lactamase_B) 		3 MET A 127
GLU A 208
ASP A 188
 None
 1.06A 3a25A-6ao1A:
undetectable		 3a25A-6ao1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza


(;
) 		no annotation
no annotation 		3 MET A  75
GLU B  25
ASP B 168
 FMT  A 907 ( 4.6A)
None
None
 1.06A 3a25A-6czaA:
undetectable		 3a25A-6czaA:
undetectable